MCID: NDL002
MIFTS: 33

Nodular Tenosynovitis

Categories: Cancer diseases, Muscle diseases

Aliases & Classifications for Nodular Tenosynovitis

MalaCards integrated aliases for Nodular Tenosynovitis:

Name: Nodular Tenosynovitis 12 15 70
Synovioma, Benign 12 70
Localized Giant Cell Tumor of Tenosynovium 12
Giant Cell Tumor of Tendon Sheath 44
Benign Tumor of Synovium 12
Benign Synovioma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2701
MeSH 44 D000070779
NCIt 50 C3829 C6532
SNOMED-CT 67 5178002 71508003
UMLS 70 C0221289 C0588125

Summaries for Nodular Tenosynovitis

MalaCards based summary : Nodular Tenosynovitis, also known as synovioma, benign, is related to pleomorphic lipoma and fibroma. An important gene associated with Nodular Tenosynovitis is SERPINA3 (Serpin Family A Member 3), and among its related pathways/superpathways are Dendritic Cells Developmental Lineage Pathway and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Sargramostim and Grapefruit Seed Extract have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and heart, and related phenotypes are immune system and muscle

Related Diseases for Nodular Tenosynovitis

Diseases related to Nodular Tenosynovitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 152)
# Related Disease Score Top Affiliating Genes
1 pleomorphic lipoma 30.8 SERPINA3 HMGA2 CD68
2 fibroma 30.8 VIM SERPINA3 S100A9 CD68
3 sarcoidosis 1 30.5 SERPINA3 S100A9 PTPRC
4 bone giant cell tumor 30.5 SERPINA3 CSF1 CD68 ACP5
5 pseudosarcomatous fibromatosis 30.5 VIM SERPINA3 CD68
6 benign giant cell tumor 30.2 VIM SERPINA3 PTPRC CSF1
7 sarcoma, synovial 30.1 VIM SERPINA3 HMGA2
8 synovitis 30.0 CD68 CD163 ACP5
9 fibrous histiocytoma 29.8 VIM SERPINA3 CD68 CD163
10 villonodular synovitis 29.8 PTPRC CSF1 CD68 ACP5
11 pigmented villonodular synovitis 29.6 SERPINA3 PTPRC CSF1 CD68 ACP5
12 tenosynovial giant cell tumor 28.9 SERPINA3 CSF1 COL6A3 CLU CD68 CD163
13 tenosynovitis 10.6
14 malignant giant cell tumor 10.5
15 verruciform xanthoma of skin 10.4 SERPINA3 CD68
16 proliferative fasciitis 10.4 SERPINA3 CD68
17 xanthogranulomatous pyelonephritis 10.3 SERPINA3 CD68
18 sarcomatoid squamous cell skin carcinoma 10.3 SERPINA3 CD68
19 malignant granular cell myoblastoma 10.3 SERPINA3 CD68
20 liver sarcoma 10.3 SERPINA3 CD68
21 cobblestone retinal degeneration 10.3 PTPRC CD68
22 lipomatosis, multiple 10.3
23 chondroma 10.3
24 chondroid lipoma 10.3 HMGA2 CD68
25 small intestinal sarcoma 10.3 PTPRC CD68
26 alzheimer disease 17 10.3 S100A9 CD68
27 glomeruloid hemangioma 10.3 PTPRC CD68
28 malignant spindle cell melanoma 10.3 SERPINA3 CD68
29 conventional fibrosarcoma 10.3 PTPRC CD68
30 giant cell reparative granuloma 10.3 SERPINA3 CD68
31 bladder sarcoma 10.3 SERPINA3 CD68
32 intravascular papillary endothelial hyperplasia 10.3 VIM SERPINA3
33 malignant inflammatory fibrous histiocytoma 10.3 SERPINA3 S100A9 CD68
34 pancreas sarcoma 10.2 SERPINA3 HMGA2 CD68
35 mesenchymal cell neoplasm 10.2 SERPINA3 HMGA2 CD68
36 ovarian mucinous cystadenocarcinoma 10.2 VIM SERPINA3
37 pediatric liposarcoma 10.2 VIM HMGA2
38 central nervous system vasculitis 10.2 SERPINA3 CD68
39 primitive neuroectodermal tumor of the cervix uteri 10.2 VIM PTPRC
40 chondroid chordoma 10.2 VIM SERPINA3
41 cutaneous leiomyosarcoma 10.2 VIM CD68
42 odontogenic myxoma 10.2 VIM SERPINA3
43 retroperitoneal fibrosis 10.2 VIM PTPRC
44 reticulosarcoma 10.2 SERPINA3 PTPRC CD68
45 spindle cell lipoma 10.2 VIM S100A9
46 embryonal sarcoma 10.2 VIM SERPINA3
47 granuloma annulare 10.2 VIM CD68
48 secretory meningioma 10.2 VIM SERPINA3
49 fibrosarcoma of bone 10.2 SERPINA3 CSF1 CD68
50 connective tissue benign neoplasm 10.2 SERPINA3 CSF1 CD68

Graphical network of the top 20 diseases related to Nodular Tenosynovitis:



Diseases related to Nodular Tenosynovitis

Symptoms & Phenotypes for Nodular Tenosynovitis

MGI Mouse Phenotypes related to Nodular Tenosynovitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.65 CD163 CD68 CLU CSF1 CYP19A1 CYP27A1
2 muscle MP:0005369 9.17 CD163 CLU COL6A3 CSF1 CYP19A1 PDPN

Drugs & Therapeutics for Nodular Tenosynovitis

Drugs for Nodular Tenosynovitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sargramostim Approved, Investigational Phase 3 123774-72-1, 83869-56-1
2 Grapefruit Seed Extract Phase 2
3 Immunoglobulins Phase 2
4 Antibodies Phase 2
5 Immunoglobulins, Intravenous Phase 2
6 Paraproteins Phase 2
7 Myeloma Proteins Phase 2
8 Antibodies, Monoclonal Phase 2

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 A Phase 4, Multicenter Study to Evaluate Discontinuation and Re-Treatment in Subjects With Tenosynovial Giant Cell Tumor (TGCT) Previously Treated With Pexidartinib Recruiting NCT04526704 Phase 4 Pexidartinib
2 Multicenter, Single Arm Study of the Efficacy and Safety of Pexidartinib in Adult Subjects With Tenosynovial Giant Cell Tumor Recruiting NCT04488822 Phase 3 Pexidartinib
3 A Double-blind, Randomized, Placebo-controlled Phase 3 Study of Orally Administered PLX3397 in Subjects With Pigmented Villonodular Synovitis or Giant Cell Tumor of the Tendon Sheath Active, not recruiting NCT02371369 Phase 3 Pexidartinib;Placebo
4 A Phase II Randomized, Double -Blind, Placebo Controlled Study to Assess Safety, Tolerability and Effect on Tumor Size of MCS110 in Patients With Pigmented Villonodular Synovitis (PVNS) Completed NCT01643850 Phase 2 MCS110;Placebo
5 Phase II Study of Nilotinib Efficacy in Pigmented Villo-Nodular Synovitis/ Tenosynovial Giant Cell Tumour (PVNS/TGCT) Completed NCT01261429 Phase 2 Tasigna
6 A Phase 1/2 Study of Cabiralizumab, an Anti-CSF1 Receptor Antibody, in Patients With Pigmented Villonodular Synovitis (PVNS)/ Diffuse Type Tenosynovial Giant Cell Tumor (Dt-TGCT) Completed NCT02471716 Phase 1, Phase 2
7 A Multicenter Phase 1/2, Open-Label Study of DCC-3014 to Assess the Safety, Efficacy, Pharmacokinetics, and Pharmacodynamics in Patients With Advanced Tumors and Tenosynovial Giant Cell Tumor Recruiting NCT03069469 Phase 1, Phase 2 DCC-3014
8 A Multi-Center Single Agent Phase II Study of the Efficacy of Nilotinib in Patients With Relapsed or Metastatic Pigmented Villonodular Synovitis/Tenosynovial Giant Cell Tumor/Diffuse-Type Giant Cell Tumor Active, not recruiting NCT01207492 Phase 2 nilotinib
9 An Adaptive, Multicenter, Open-Label Study to Evaluate the Safety, Tolerability, Efficacy, and Pharmacokinetics of Intra-articular AMB-05X Injections in Subjects With Tenosynovial Giant Cell Tumor of the Knee Not yet recruiting NCT04731675 Phase 2
10 A Phase 2, Multicenter, Two-Part, Open-Label Study of Pexidartinib in Adult Subjects With Tenosynovial Giant Cell Tumor in Japan Not yet recruiting NCT04703322 Phase 2 Pexidartinib
11 A Phase 1 Study to Assess Safety, Pharmacokinetics, and Pharmacodynamics of PLX73086 as a Single Agent in Subjects With Advanced Solid Tumors and in Subjects With Locally Advanced or Refractory Tenosynovial Giant Cell Tumor (TGCT) Terminated NCT02673736 Phase 1 PLX73086
12 A Phase 1 Study to Assess Safety, Pharmacokinetics, and Pharmacodynamics of PLX7486 as a Single Agent in Patients With Advanced Solid Tumors Terminated NCT01804530 Phase 1 PLX7486 TsOH
13 A Long-term Study to Further Evaluate the Risk of Hepatotoxicity Associated With TURALIO™ (Pexidartinib) Treatment Recruiting NCT04635111 TURALIO™
14 A Disease Registry for Patients With Tenosynovial Giant Cell Tumors (TGCT), Also Known as Pigmented Villonodular Synovitis (PVNS) and Giant Cell Tumor of the Tendon Sheath (GCT-TS) Active, not recruiting NCT02948088

Search NIH Clinical Center for Nodular Tenosynovitis

Cochrane evidence based reviews: giant cell tumor of tendon sheath

Genetic Tests for Nodular Tenosynovitis

Anatomical Context for Nodular Tenosynovitis

MalaCards organs/tissues related to Nodular Tenosynovitis:

40
Bone, Skin, Heart, Smooth Muscle, Liver, Pancreas, Breast

Publications for Nodular Tenosynovitis

Articles related to Nodular Tenosynovitis:

(show all 37)
# Title Authors PMID Year
1
Multifocal giant cell tumors of tendon sheath along a single tendon: A case report with review of literature. 61
32684714 2020
2
Nodular Tenosynovitis of the Temporomandibular Joint: An Entity Not Yet Described. 61
29762327 2018
3
Pigmented villonodular synovitis. 61
30745604 2018
4
Localized Nodular Tenosynovitis Originated near the Medial Plicae. 61
24639948 2014
5
The management of diffuse-type giant cell tumour (pigmented villonodular synovitis) and giant cell tumour of tendon sheath (nodular tenosynovitis). 61
22733940 2012
6
Pigmented villonodular bursitis/diffuse giant cell tumor of the pes anserine bursa: a report of two cases and review of literature. 61
17669658 2007
7
Combined ulnar and carpal tunnel syndrome caused by pigmented villo-nodular tenosynovitis: a rare case. 61
17522877 2007
8
Radiological reasoning: Acutely painful swollen finger. 61
17312081 2007
9
[Diagnosis and therapy of nodular tenosynovitis of the tendon sheath--case presentation]. 61
12219636 2002
10
Giant cell tumour of tendon sheath (localised nodular tenosynovitis): clinicopathological features of 71 cases. 61
11328844 2001
11
[Pigmented nodular tenosynovitis. A misdiagnosed etiology of isolated tumefaction of fingers or toes]. 61
9747320 1998
12
Intraosseous growth of giant cell tumors of the tendon sheath (localized nodular tenosynovitis) of the digits: report of 15 cases. 61
9708390 1998
13
Cytomorphology of giant cell tumor of tendon sheath. A report of two cases. 61
9100804 1997
14
A new cytogenetic subgroup in tenosynovial giant cell tumors (nodular tenosynovitis) is characterized by involvement of 16q24. 61
8646750 1996
15
Diffuse tenosynovial giant cell tumor of soft tissues. Report of a case with cytologic and cytogenetic findings. 61
7631554 1995
16
Fibroma and giant cell tumor of tendon sheath: a comparative histological and immunohistological study. 61
7777476 1995
17
Cytogenetic characterization of tenosynovial giant cell tumors (nodular tenosynovitis). 61
8033128 1994
18
Fine-needle aspiration biopsy cytology of giant-cell tumor of tendon sheath. 61
8037172 1994
19
[Late flexor synovitis induced by the use of a fabric lace]. 61
7511914 1994
20
Malignant giant cell tumor of the tendon sheath: an autopsy report and review of the literature. 61
8230758 1993
21
Chromosome aberrations in tenosynovial giant cell tumors and nontumorous synovial tissue. 61
7685623 1993
22
Fibrous loose body in the flexor tendon sheath. 61
1995689 1991
23
[Cytological diagnosis of nodular tenosynovitis]. 61
1767521 1991
24
Giant cell tumor of tendon sheath. 61
2555312 1989
25
Giant cell tumor of the tendon sheath (nodular tenosynovitis). A study of 207 cases to compare the large joint group with the common digit group. 61
3943019 1986
26
Giant cell tumor of tendon sheath (localized nodular tenosynovitis). 61
6497267 1984
27
Localized nodular tenosynovitis: experience with 115 cases. 61
6327803 1984
28
Fibroma of tendon sheath. 61
7107956 1982
29
[Clinical and pathomorphological aspects of nodular tenosynovitis of the hand]. 61
535458 1979
30
[Tumors and tumor-like lesions of the hand]. 61
914105 1977
31
[Tenosynovitis nodosa]. 61
1027662 1976
32
Nodular tenosynovitis. Benign giant cell synovioma. 61
4376498 1974
33
[2 cases of localized nodular tenosynovitis of the fingers]. 61
5169909 1971
34
[Localized nodular tenosynovitis of the fingers]. 61
5393173 1969
35
Localized nodular tenosynovitis in the horse. 61
5752522 1968
36
Localized nodular tenosynovitis with involvement of bone. 61
6074871 1967
37
Pigmented nodular tenosynovitis of the hand with erosion of bone. 61
13453740 1957

Variations for Nodular Tenosynovitis

Expression for Nodular Tenosynovitis

Search GEO for disease gene expression data for Nodular Tenosynovitis.

Pathways for Nodular Tenosynovitis

Pathways related to Nodular Tenosynovitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11 PTPRC CSF1 CD163
2 10.99 PTPRC CSF1 CD68 CD163
3 10.36 CSF1 CD68

GO Terms for Nodular Tenosynovitis

Cellular components related to Nodular Tenosynovitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 collagen-containing extracellular matrix GO:0062023 8.92 SERPINA3 S100A9 COL6A3 CLU

Biological processes related to Nodular Tenosynovitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.62 SERPINA3 S100A9 CSF1 CD163
2 sterol metabolic process GO:0016125 9.37 CYP27A1 CYP19A1
3 astrocyte development GO:0014002 9.26 VIM S100A9
4 positive regulation of stem cell proliferation GO:2000648 9.16 PTPRC HMGA2
5 microglial cell proliferation GO:0061518 8.96 CSF1 CLU
6 autocrine signaling GO:0035425 8.62 S100A9 CD68

Sources for Nodular Tenosynovitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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