MCID: NDL002
MIFTS: 27

Nodular Tenosynovitis

Categories: Cancer diseases, Muscle diseases

Aliases & Classifications for Nodular Tenosynovitis

MalaCards integrated aliases for Nodular Tenosynovitis:

Name: Nodular Tenosynovitis 12 15 73
Synovioma, Benign 12 73
Localized Giant Cell Tumor of Tenosynovium 12
Giant Cell Tumor of Tendon Sheath 44
Benign Tumor of Synovium 12
Benign Synovioma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2701
MeSH 44 D000070779
NCIt 50 C3829 C6532

Summaries for Nodular Tenosynovitis

MalaCards based summary : Nodular Tenosynovitis, also known as synovioma, benign, is related to giant cell tumor and tenosynovial giant cell tumor. An important gene associated with Nodular Tenosynovitis is SERPINA3 (Serpin Family A Member 3), and among its related pathways/superpathways is Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Grapefruit Seed Extract and Immunoglobulins have been mentioned in the context of this disorder. Affiliated tissues include bone, brain and thymus.

Related Diseases for Nodular Tenosynovitis

Diseases related to Nodular Tenosynovitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 48)
# Related Disease Score Top Affiliating Genes
1 giant cell tumor 30.6 PTPRC SERPINA3
2 tenosynovial giant cell tumor 11.8
3 tenosynovitis 10.5
4 hemangioma 10.2
5 bone giant cell tumor 10.2
6 sclerosing hemangioma 10.2
7 lipoadenoma 10.1 HMGA2 SERPINA3
8 inflammatory mfh 10.1 CD68 SERPINA3
9 malignant giant cell tumor 10.1
10 pyogenic granuloma 10.1
11 conventional leiomyosarcoma 10.1 CD68 HMGA2
12 granular cell tumor 10.1 CD68 SERPINA3
13 extracutaneous mastocytoma 10.1 CD68 PTPRC
14 xanthogranulomatous pyelonephritis 10.1 CD68 SERPINA3
15 malignant giant cell tumor of soft parts 10.1 CD68 PTPRC
16 brain sarcoma 10.0 CD68 PTPRC
17 glomeruloid hemangioma 10.0 CD68 PTPRC
18 thymus lipoma 10.0 HMGA2 PTPRC
19 conventional fibrosarcoma 10.0 CD68 PTPRC
20 hodgkin's lymphoma, lymphocytic depletion 10.0 CD68 PTPRC
21 trigeminal nerve neoplasm 10.0 CD68 PTPRC
22 immune system organ benign neoplasm 10.0 HMGA2 PTPRC
23 neurilemmoma of the fifth cranial nerve 10.0 CD68 PTPRC
24 malignant fibroxanthoma 10.0 PTPRC SERPINA3
25 photokeratitis 10.0 CD68 PTPRC
26 adult xanthogranuloma 10.0 CD68 S100A9
27 diffuse meningeal melanocytosis 10.0 CD68 S100A9
28 dendritic cell tumor 10.0 CD68 PTPRC
29 erythema elevatum diutinum 10.0 CD68 S100A9
30 retinal hemangioblastoma 10.0 S100A9 SERPINA3
31 reticulum cell sarcoma 10.0 PTPRC S100A9
32 connective tissue cancer 10.0 CD68 SERPINA3
33 melkersson-rosenthal syndrome 10.0 CD68 PTPRC
34 congenital epulis 10.0 CD68 S100A9
35 histiocytosis 9.9 PTPRC SERPINA3
36 scrotal carcinoma 9.9 CD68 HMGA2 SERPINA3
37 carpal tunnel syndrome 9.9
38 mononeuropathy of the median nerve, mild 9.9
39 pigmented villonodular synovitis 9.9
40 synovitis 9.9
41 villonodular synovitis 9.9
42 central nervous system melanocytic neoplasm 9.9 CD68 S100A9
43 fibrosarcoma of bone 9.9 PTER SERPINA3
44 histiocytoma 9.9 PTPRC SERPINA3
45 xanthogranulomatous cholecystitis 9.9 CD68 S100A9 SERPINA3
46 sarcoidosis 1 9.8 CD68 PTPRC
47 leber congenital amaurosis 9.7 CD68 PTPRC S100A9
48 reticulohistiocytic granuloma 9.7 CD68 PTPRC S100A9 SERPINA3

Graphical network of the top 20 diseases related to Nodular Tenosynovitis:



Diseases related to Nodular Tenosynovitis

Symptoms & Phenotypes for Nodular Tenosynovitis

Drugs & Therapeutics for Nodular Tenosynovitis

Drugs for Nodular Tenosynovitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Grapefruit Seed Extract Phase 2
2 Immunoglobulins Phase 1, Phase 2
3 Antibodies Phase 1, Phase 2
4
Paclitaxel Approved, Vet_approved Phase 1 33069-62-4 36314
5
Tolbutamide Approved, Investigational Phase 1 64-77-7 5505
6
Midazolam Approved, Illicit Phase 1 59467-70-8 4192
7 Antineoplastic Agents, Phytogenic Phase 1
8 Albumin-Bound Paclitaxel Phase 1
9 Antimitotic Agents Phase 1
10 Hypnotics and Sedatives Phase 1
11 Anti-Anxiety Agents Phase 1
12 Hypoglycemic Agents Phase 1
13 Central Nervous System Depressants Phase 1
14 GABA Agents Phase 1
15 Neurotransmitter Agents Phase 1
16 Anesthetics, General Phase 1
17 Anesthetics, Intravenous Phase 1
18 Tranquilizing Agents Phase 1
19 Anesthetics Phase 1
20 Adjuvants, Anesthesia Phase 1
21 Psychotropic Drugs Phase 1
22 GABA Modulators Phase 1

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Phase 3 Study of Pexidartinib for Pigmented Villonodular Synovitis (PVNS) or Giant Cell Tumor of the Tendon Sheath (GCT-TS) Active, not recruiting NCT02371369 Phase 3 Pexidartinib;Placebo
2 Study of Nilotinib Efficacy in Pigmented Villo-Nodular Synovitis/ Tenosynovial Giant Cell Tumour (PVNS/TGCT) Completed NCT01261429 Phase 2 Tasigna
3 Study of Cabiralizumab in Patients With Pigmented Villonodular Synovitis / Diffuse Type Tenosynovial Giant Cell Tumor Active, not recruiting NCT02471716 Phase 1, Phase 2
4 Nilotinib in Patients With Relapsed or Metastatic Pigmented Villonodular Synovitis/Tenosynovial Giant Cell Tumor/Diffuse-Type Giant Cell Tumor Active, not recruiting NCT01207492 Phase 2 nilotinib
5 MCS110 in Patients With Pigmented Villonodular Synovitis (PVNS) Active, not recruiting NCT01643850 Phase 2 MCS110;Placebo;MCS110;Placebo
6 A Study of RO5509554 as Monotherapy and in Combination With Paclitaxel in Participants With Advanced Solid Tumors Completed NCT01494688 Phase 1 Paclitaxel;RO5509554
7 Effect of Pexidartinib on the Way the Body Processes CYP3A4 and CYP2C9 Substrates (Pharmacokinetics) Active, not recruiting NCT03291288 Phase 1 Tolbutamide;Midazolam;Pexidartinib
8 A Study of PLX73086 in Advanced Solid Tumors and Locally Advanced or Refractory Tenosynovial Giant Cell Tumor Terminated NCT02673736 Phase 1 PLX73086
9 Phase 1 Study of PLX7486 as Single Agent in Patients With Advanced Solid Tumors Terminated NCT01804530 Phase 1 PLX7486 TsOH
10 Tenosynovial Giant Cell Tumors (TGCT) Observational Platform Project Recruiting NCT02948088
11 Evaluation of the Effectiveness of Surgical Treatment of Villo-nodular Synovitis of the Hip in Children Recruiting NCT03507933

Search NIH Clinical Center for Nodular Tenosynovitis

Cochrane evidence based reviews: giant cell tumor of tendon sheath

Genetic Tests for Nodular Tenosynovitis

Anatomical Context for Nodular Tenosynovitis

MalaCards organs/tissues related to Nodular Tenosynovitis:

41
Bone, Brain, Thymus

Publications for Nodular Tenosynovitis

Articles related to Nodular Tenosynovitis:

(show all 15)
# Title Authors Year
1
Nodular Tenosynovitis of the Temporomandibular Joint: An Entity Not Yet Described. ( 29762327 )
2018
2
Localized Nodular Tenosynovitis Originated near the Medial Plicae. ( 24639948 )
2014
3
The management of diffuse-type giant cell tumour (pigmented villonodular synovitis) and giant cell tumour of tendon sheath (nodular tenosynovitis). ( 22733940 )
2012
4
Combined ulnar and carpal tunnel syndrome caused by pigmented villo-nodular tenosynovitis: a rare case. ( 17522877 )
2007
5
Giant cell tumour of tendon sheath (localised nodular tenosynovitis): clinicopathological features of 71 cases. ( 11328844 )
2001
6
Intraosseous growth of giant cell tumors of the tendon sheath (localized nodular tenosynovitis) of the digits: report of 15 cases. ( 9708390 )
1998
7
A new cytogenetic subgroup in tenosynovial giant cell tumors (nodular tenosynovitis) is characterized by involvement of 16q24. ( 8646750 )
1996
8
Cytogenetic characterization of tenosynovial giant cell tumors (nodular tenosynovitis). ( 8033128 )
1994
9
Giant cell tumor of the tendon sheath (nodular tenosynovitis). A study of 207 cases to compare the large joint group with the common digit group. ( 3943019 )
1986
10
Giant cell tumor of tendon sheath (localized nodular tenosynovitis). ( 6497267 )
1984
11
Localized nodular tenosynovitis: experience with 115 cases. ( 6327803 )
1984
12
Nodular tenosynovitis. Benign giant cell synovioma. ( 4376498 )
1974
13
Localized nodular tenosynovitis in the horse. ( 5752522 )
1968
14
Localized nodular tenosynovitis with involvement of bone. ( 6074871 )
1967
15
Pigmented nodular tenosynovitis of the hand with erosion of bone. ( 13453740 )
1957

Variations for Nodular Tenosynovitis

Expression for Nodular Tenosynovitis

Search GEO for disease gene expression data for Nodular Tenosynovitis.

Pathways for Nodular Tenosynovitis

Pathways related to Nodular Tenosynovitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.69 CD68 PTPRC

GO Terms for Nodular Tenosynovitis

Cellular components related to Nodular Tenosynovitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.26 PTER PTPRC S100A9 SERPINA3
2 secretory granule lumen GO:0034774 8.62 S100A9 SERPINA3

Biological processes related to Nodular Tenosynovitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of stem cell proliferation GO:2000648 8.96 HMGA2 PTPRC
2 neutrophil degranulation GO:0043312 8.92 CD68 PTPRC S100A9 SERPINA3

Sources for Nodular Tenosynovitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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