NOMA
MCID: NM001
MIFTS: 46

Noma (NOMA)

Categories: Infectious diseases, Oral diseases, Rare diseases

Aliases & Classifications for Noma

MalaCards integrated aliases for Noma:

Name: Noma 12 76 53 59 44 15 73
Cancrum Oris 12 53 59
Oro-Facial Gangrene 53 73
Gangrenous Stomatitis 12
Noma Neonatorum 53
Oro-Facial Noma 53
Oral Gangrene 53

Characteristics:

Orphanet epidemiological data:

59
noma
Age of onset: Childhood;

Classifications:

Orphanet: 59  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:9672
ICD10 33 A69.0
ICD9CM 35 528.1
MeSH 44 D009625
NCIt 50 C34852
SNOMED-CT 68 18116006
Orphanet 59 ORPHA2700
UMLS via Orphanet 74 C0028271
ICD10 via Orphanet 34 A69.0
MESH via Orphanet 45 D009625

Summaries for Noma

MalaCards based summary : Noma, also known as cancrum oris, is related to acatalasemia and gingivitis, and has symptoms including oral manifestations An important gene associated with Noma is ARHGAP33 (Rho GTPase Activating Protein 33), and among its related pathways/superpathways are Signaling by GPCR and TGF-Beta Pathway. The drugs Estradiol and Estradiol valerate have been mentioned in the context of this disorder. Affiliated tissues include bone, kidney and pituitary, and related phenotypes are cellular and homeostasis/metabolism

Wikipedia : 76 Noma is a rapidly progressive, polymicrobial, often gangrenous infection of the mouth or... more...

Related Diseases for Noma

Diseases related to Noma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 68)
# Related Disease Score Top Affiliating Genes
1 acatalasemia 11.5
2 gingivitis 10.2
3 stomatitis 10.2
4 pyuria 10.2 ALB CXCL8
5 sapho syndrome 10.2 CXCL8 IL18
6 ankylosis 10.2
7 fasciitis 10.2
8 necrotizing fasciitis 10.2
9 diabetes mellitus, noninsulin-dependent 10.2
10 down syndrome 10.2
11 diabetes mellitus 10.2
12 dysentery 10.2
13 typhoid fever 10.2
14 human immunodeficiency virus infectious disease 10.2
15 pneumonia 10.2
16 capillary leak syndrome 10.1 ALB CXCL8
17 acute cystitis 10.1 ALB CXCL8 IL18
18 extrinsic allergic alveolitis 10.1 ALB CXCL8 IL18
19 aleutian mink disease 10.1 ALB NGFR
20 chylothorax, congenital 10.1 ALB PTPN11
21 cerebrovascular disease 10.1
22 epulis 10.1 NGFR PGR
23 tricuspid valve insufficiency 10.1 ALB PTPN11
24 euthyroid sick syndrome 10.0 ALB POMC
25 leukemia 10.0
26 neutropenia 10.0
27 necrotizing ulcerative gingivitis 10.0
28 acquired immunodeficiency syndrome 10.0
29 viral infectious disease 10.0
30 severe nonproliferative diabetic retinopathy 10.0 ALB INS
31 sella turcica neoplasm 10.0 PGR POMC
32 suprasellar meningioma 10.0 PGR POMC
33 drug allergy 10.0 ALB INS
34 tuberculum sellae meningioma 10.0 PGR POMC
35 thyroid crisis 10.0 ALB POMC
36 background diabetic retinopathy 10.0 ALB INS
37 syndrome of inappropriate antidiuretic hormone 9.9 ALB POMC
38 gastrointestinal system disease 9.9 ALB CXCL8 INS
39 scleredema adultorum 9.9 INS POMC
40 pituitary apoplexy 9.9 INS POMC
41 pancreatic endocrine carcinoma 9.9 INS POMC
42 cyclic neutropenia 9.9
43 myeloperoxidase deficiency 9.9
44 acute promyelocytic leukemia 9.9
45 leukemia, acute lymphoblastic 9.9
46 acute lymphocytic leukemia 9.9
47 severe combined immunodeficiency 9.9
48 bone resorption disease 9.9
49 lymphocytic leukemia 9.9
50 myiasis 9.9

Graphical network of the top 20 diseases related to Noma:



Diseases related to Noma

Symptoms & Phenotypes for Noma

UMLS symptoms related to Noma:


oral manifestations

MGI Mouse Phenotypes related to Noma:

46 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.16 ALB ARHGAP1 IL18 INS MAPK7 NGFR
2 homeostasis/metabolism MP:0005376 10.1 ALB ARHGAP1 IL18 INS MAPK7 NGFR
3 cardiovascular system MP:0005385 10.08 ARHGAP33 IL18 INS MAPK7 NGFR PGR
4 adipose tissue MP:0005375 9.97 ARHGAP1 IL18 INS NGFR POMC PTPN11
5 integument MP:0010771 9.97 ARHGAP1 IL18 INS MAPK7 NGFR PGR
6 mortality/aging MP:0010768 9.96 ALB ARHGAP1 ARHGAP33 IL18 INS MAPK7
7 digestive/alimentary MP:0005381 9.91 ALB IL18 INS MAPK7 NGFR PTPN11
8 liver/biliary system MP:0005370 9.87 ALB ARHGAP1 INS NGFR POMC PTN
9 muscle MP:0005369 9.76 ALB ARHGAP1 IL18 INS MAPK7 NGFR
10 nervous system MP:0003631 9.61 ARHGAP1 ARHGAP33 IL18 INS MAPK7 NGFR
11 renal/urinary system MP:0005367 9.1 ALB ARHGAP1 INS MAPK7 NGFR POMC

Drugs & Therapeutics for Noma

Drugs for Noma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 38)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Estradiol Approved, Investigational, Vet_approved Phase 3 50-28-2 5757
2 Estradiol valerate Approved, Investigational, Vet_approved Phase 3 979-32-8
3
Progesterone Approved, Vet_approved Phase 3 57-83-0 5994
4
Polyestradiol phosphate Approved Phase 3 28014-46-2
5
Alogliptin Approved Phase 3 850649-61-5 11450633
6
Darbepoetin alfa Approved, Investigational Phase 3 11096-26-7, 209810-58-2
7
Exemestane Approved, Investigational Phase 3 107868-30-4 60198
8
Letrozole Approved, Investigational Phase 3 112809-51-5 3902
9
Anastrozole Approved, Investigational Phase 3 120511-73-1 2187
10
Trastuzumab Approved, Investigational Phase 3 180288-69-1 9903
11
Capecitabine Approved, Investigational Phase 3 154361-50-9 60953
12
Oxaliplatin Approved, Investigational Phase 3 61825-94-3 43805 6857599 5310940 9887054
13
Lapatinib Approved March 2007, Investigational Phase 3 388082-78-8, 231277-92-2 208908 9941095
14 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
15 Hormone Antagonists Phase 3
16 Progestins Phase 3
17 Estradiol 3-benzoate Phase 3
18 Estradiol 17 beta-cypionate Phase 3
19 Hormones Phase 3
20 Estrogens Phase 3
21 Contraceptive Agents Phase 3
22 Angiogenesis Inhibitors Phase 3,Not Applicable
23 Hypoglycemic Agents Phase 3
24 HIV Protease Inhibitors Phase 3
25 Incretins Phase 3
26 Dipeptidyl-Peptidase IV Inhibitors Phase 3
27
protease inhibitors Phase 3
28 Hematinics Phase 3
29 Estrogen Antagonists Phase 3
30 Protein Kinase Inhibitors Phase 3
31 Steroid Synthesis Inhibitors Phase 3
32 Estrogen Receptor Antagonists Phase 3
33 Aromatase Inhibitors Phase 3
34 Antimetabolites Phase 3
35 Antimetabolites, Antineoplastic Phase 3
36
Ranibizumab Approved Not Applicable 347396-82-1 459903
37 Immunologic Factors Not Applicable
38 Angiogenesis Modulating Agents Not Applicable

Interventional clinical trials:

(show all 17)
# Name Status NCT ID Phase Drugs
1 POPART'MUS: Prevention of Post Partum Relapses With Progestin and Estradiol in Multiple Sclerosis Unknown status NCT00127075 Phase 3 nomegestrol acetate;estradiol;placebo
2 Cardiovascular Outcomes Study of Alogliptin in Patients With Type 2 Diabetes and Acute Coronary Syndrome Completed NCT00968708 Phase 3 Alogliptin;Placebo
3 RED-HF™ Trial - Reduction of Events With Darbepoetin Alfa in Heart Failure Trial Completed NCT00358215 Phase 3 Darbepoetin alfa;Placebo
4 A Safety and Efficacy Study of Relamorelin in Diabetic Gastroparesis Study 04 Recruiting NCT03383146 Phase 3 Relamorelin;Placebo
5 A Study to Evaluate Pazopanib as an Adjuvant Treatment for Localized Renal Cell Carcinoma (RCC) Active, not recruiting NCT01235962 Phase 3 pazopanib;placebo
6 A Study to Compare the Safety and Efficacy of an Aromatase Inhibitor in Combination With Lapatinib, Trastuzumab or Both for the Treatment of Hormone Receptor Positive, HER2+ Metastatic Breast Cancer Active, not recruiting NCT01160211 Phase 3 lapatinib;trastuzumab;Aromatase inhibitor;lapatinib
7 LOGiC - Lapatinib Optimization Study in ErbB2 (HER2) Positive Gastric Cancer: A Phase III Global, Blinded Study Designed to Evaluate Clinical Endpoints and Safety of Chemotherapy Plus Lapatinib Active, not recruiting NCT00680901 Phase 3 Lapatinib;Placebo;Capecitabine;Oxaliplatin
8 A Three-part Study of Eltrombopag in Thrombocytopenic Subjects With Myelodysplastic Syndromes or Acute Myeloid Leukemia Completed NCT01440374 Phase 2 eltrombopag;placebo
9 Development of Intravitreal Ranibizumab by Determining the Pathogenesis of Macular Edema With Retinal Vein Occlusion Unknown status NCT02169648 Not Applicable ranibizumab
10 Stroke Incidence and Risk Factors in a Tri-ethnic Region Completed NCT03266952
11 Fat Quality on Blood Lipids and Immune Response Completed NCT01679496 Not Applicable
12 Comparison of Non-nutritive Suck (NNS) Measures to Clinical Estimates of Suck and Feeding Readiness in Preterm Infants Completed NCT01069731
13 Evaluating Dysphagia in Neonates With CHD Recruiting NCT03045757
14 Pacifier Activated Device and Mother's Voice in Infants at High-risk for Cerebral Palsy Recruiting NCT03230032 Not Applicable
15 Direct Swallowing Training and Oral Sensorimotor Stimulation in Preterm Infants Recruiting NCT02508571 Not Applicable
16 Japanese Idiopathic Interstitial Pneumonias Registry Recruiting NCT03041623
17 Supporting and Enhancing NICU Sensory Experiences (SENSE) Active, not recruiting NCT03316547 Not Applicable

Search NIH Clinical Center for Noma

Cochrane evidence based reviews: noma

Genetic Tests for Noma

Anatomical Context for Noma

MalaCards organs/tissues related to Noma:

41
Bone, Kidney, Pituitary, Pancreas, Thyroid, T Cells, B Cells

Publications for Noma

Articles related to Noma:

(show top 50) (show all 276)
# Title Authors Year
1
The Progress on Noma Disease and Its Surgical Treatment. ( 29538189 )
2018
2
Optimal Resource Allocation for NOMA-TDMA Scheme with I+-Fairness in Industrial Internet of Things. ( 29762506 )
2018
3
Evaluation of the Noma Disease Burden Within the Noma Belt. ( 29800992 )
2018
4
An unusual case of noma caused by Klebsiella pnuemoniae and its management. ( 29368993 )
2018
5
The surgical management of extra-articular ankylosis in noma patients. ( 30104131 )
2018
6
Cancrum oris (noma): An early sign of acute lymphoblastic leukemia relapse. ( 28799529 )
2018
7
Risk factors for diagnosed noma in northwest Nigeria: A case-control study, 2017. ( 30138374 )
2018
8
Noma surgery. ( 30194753 )
2018
9
RF Energy Harvesting and Information Transmission Based on NOMA for Wireless Powered IoT Relay Systems. ( 30262773 )
2018
10
Application of NOMA in Wireless System with Wireless Power Transfer Scheme: Outage and Ergodic Capacity Performance Analysis. ( 30336586 )
2018
11
Performance improvement of NOMA visible light communication system by adjusting superposition constellation: a convex optimization approach. ( 30469938 )
2018
12
Noma Neonatorum: A Disease Long Forgotten. ( 30550012 )
2018
13
A progressive ulcer in immunocompetent man: cancrum oris. ( 28541141 )
2018
14
Experimental demonstration of bidirectional NOMA-OFDMA visible light communications. ( 28241638 )
2017
15
Worst-Case Energy Efficiency Maximization in a 5G Massive MIMO-NOMA System. ( 28927019 )
2017
16
Noma: Time to Address a Collective Moral Failure. ( 28115663 )
2017
17
Noma in an HIV infected patient in Guinea-Bissau: a case report. ( 28589415 )
2017
18
Noma in a patient with HIV. ( 28555591 )
2017
19
Noma as a complication of false teeth (Ebiino) extraction: a case report. ( 28412977 )
2017
20
Management of noma: practice competence and knowledge among healthcare workers in a rural district of Zambia. ( 28678680 )
2017
21
Acute necrotising gingivitis in young children from villages with and without noma in Niger and its association with sociodemographic factors, nutritional status and oral hygiene practices: results of a population-based survey. ( 29082004 )
2017
22
Face of Noma and Extreme Poverty: Development of an Economic Index Derivable From Health Data. ( 28582299 )
2017
23
Solution for error propagation in a NOMA-based VLC network: symmetric superposition coding. ( 29221021 )
2017
24
Noma: Overview of a Neglected Disease and Human Rights Violation. ( 28093536 )
2017
25
Noma in a child with acute leukaemia: when the 'face of poverty' finds an ally. ( 26740267 )
2016
26
People living with facial disfigurement after having had noma disease: A systematic review of the literature. ( 26837690 )
2016
27
Facing noma. ( 27788987 )
2016
28
SERUM LEVELS OF FA^BROBLAST GROWTH FACTOR-23, OSTEOPROTEGERA^N AND RECEPTOR ACTA^VATOR OF NUCLEAR FACTOR KAPPA B LA^GAND (RANKL) A^N PATA^ENTS WA^H PROLACTA^NOMA. ( 27849387 )
2016
29
Noma Neonatorum From Multidrug-Resistant Pseudomonas aeruginosa: An Underestimated Threat? ( 26407438 )
2015
30
Noma: A disease of poverty presenting at an urban hospital in the United States. ( 27075129 )
2015
31
NOMA-GAP/ARHGAP33 regulates synapse development and autistic-like behavior in the mouse. ( 25869807 )
2015
32
A Review on Noma: A Recent Update. ( 26573028 )
2015
33
Cancrum Oris (Noma): The Role of Nutrition in Management. ( 28053869 )
2015
34
Enabling Virtual Screening of Potent and Safer Antimicrobial Agents Against Noma: mtk-QSBER Model for Simultaneous Prediction of Antibacterial Activities and ADMET Properties. ( 25769968 )
2015
35
Bony fusion of the maxilla and mandible as a sequelae of noma: A rare case report. ( 26389063 )
2015
36
Noma: neglected, forgotten and a human rights issue. ( 25609756 )
2015
37
Apnoeic oxygenation in noma patients. ( 25959184 )
2015
38
Paul Tessier facial reconstruction in 1970 Iran, a series of post-noma defects. ( 25817742 )
2015
39
Noma affected children from niger have distinct oral microbial communities based on high-throughput sequencing of 16S rRNA gene fragments. ( 25474262 )
2014
40
Acute gangrenous gingivitis--early stage noma. ( 24825288 )
2014
41
Noma and Cervicofacial Necrotizing Fasciitis: Clinicopathological Differentiation and an Illustrative Case Report of Noma. ( 24304357 )
2014
42
Noma (cancrum oris) in the South African context. ( 23647162 )
2014
43
A noma case study. ( 25668873 )
2014
44
Noma (cancrum oris): a report of a case in a young AIDS patient with a review of the pathogenesis. ( 22907664 )
2013
45
Noma in an immunocompromised patient. ( 24192747 )
2013
46
Special article: airway management in reconstructive surgery for noma (cancrum oris). ( 23733840 )
2013
47
Microarray analysis of microbiota of gingival lesions in noma patients. ( 24086784 )
2013
48
Noma neonatorum. ( 23667229 )
2013
49
Risk factors for noma disease: a 6-year, prospective, matched case-control study in Niger. ( 25104163 )
2013
50
Noma: a neglected enigma. ( 25104148 )
2013

Variations for Noma

Expression for Noma

Search GEO for disease gene expression data for Noma.

Pathways for Noma

Pathways related to Noma according to GeneCards Suite gene sharing:

(show all 23)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.97 ARHGAP1 ARHGAP33 CDC42 CXCL8 INS MAPK7
2
Show member pathways
13.21 CDC42 CXCL8 IL18 INS MAPK7 NGFR
3
Show member pathways
12.93 CDC42 CXCL8 IL18 MAPK7 NGFR PTN
4
Show member pathways
12.55 CDC42 INS NGFR PTPN11
5
Show member pathways
12.53 CDC42 MAPK7 NGFR PTPN11
6
Show member pathways
12.28 ARHGAP33 INS MAPK7 PTPN11
7
Show member pathways
12.2 CDC42 CXCL8 INS PTPN11
8 12 CDC42 MAPK7 PTPN11
9
Show member pathways
11.94 CDC42 MAPK7 NGFR
10 11.86 ALB INS NGFR
11 11.81 ARHGAP1 CDC42 MAPK7
12 11.79 CDC42 CXCL8 NGFR
13 11.76 CXCL8 IL18 POMC
14 11.74 CDC42 MAPK7 PTPN11
15
Show member pathways
11.67 CXCL8 IL18 NGFR PTN PTPN11
16 11.62 CXCL8 IL18 POMC
17 11.62 CDC42 MAPK7 NGFR PTPN11
18
Show member pathways
11.56 CXCL8 IL18 NGFR PTN PTPN11
19 11.54 CDC42 CXCL8 IL18
20
Show member pathways
11.37 CDC42 NGFR PTPN11
21 10.91 ARHGAP1 CDC42 NGFR
22 10.91 IL18 PGR
23 10.03 CXCL8 POMC PTN

GO Terms for Noma

Cellular components related to Noma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein-containing complex GO:0032991 9.02 ALB ARHGAP33 CDC42 PTN PTPN11

Biological processes related to Noma according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.71 CXCL8 IL18 POMC PTPN11
2 regulation of small GTPase mediated signal transduction GO:0051056 9.7 ARHGAP1 ARHGAP33 CDC42
3 small GTPase mediated signal transduction GO:0007264 9.63 ARHGAP1 ARHGAP33 CDC42
4 cell-cell signaling GO:0007267 9.56 IL18 INS PGR POMC
5 regulation of signaling receptor activity GO:0010469 9.55 CXCL8 IL18 INS POMC PTN
6 positive regulation of protein localization to nucleus GO:1900182 9.54 INS NGFR
7 neurotrophin TRK receptor signaling pathway GO:0048011 9.51 NGFR PTPN11
8 Rho protein signal transduction GO:0007266 9.5 ARHGAP1 CDC42 NGFR
9 positive regulation of insulin receptor signaling pathway GO:0046628 9.49 INS PTPN11
10 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway GO:1902176 9.43 INS MAPK7
11 neutrophil activation GO:0042119 9.37 CXCL8 IL18
12 wybutosine biosynthetic process GO:0031591 8.96 TRMT12 TYW3
13 glucose homeostasis GO:0042593 8.92 INS NGFR POMC PTPN11
14 signal transduction GO:0007165 10.02 ARHGAP1 ARHGAP33 CXCL8 MAPK7 NGFR PGR

Molecular functions related to Noma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 insulin receptor binding GO:0005158 8.96 INS PTPN11
2 tRNA methyltransferase activity GO:0008175 8.62 TRMT12 TYW3

Sources for Noma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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