MCID: NM001
MIFTS: 49

Noma

Categories: Rare diseases, Infectious diseases, Oral diseases

Aliases & Classifications for Noma

MalaCards integrated aliases for Noma:

Name: Noma 12 76 53 59 44 15 73
Cancrum Oris 12 53 59
Oro-Facial Gangrene 53 73
Gangrenous Stomatitis 12
Noma Neonatorum 53
Oro-Facial Noma 53
Oral Gangrene 53

Characteristics:

Orphanet epidemiological data:

59
noma
Age of onset: Childhood;

Classifications:

Orphanet: 59  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:9672
ICD10 33 A69.0
ICD9CM 35 528.1
MeSH 44 D009625
NCIt 50 C34852
Orphanet 59 ORPHA2700
UMLS via Orphanet 74 C0028271
ICD10 via Orphanet 34 A69.0
MESH via Orphanet 45 D009625

Summaries for Noma

MalaCards based summary : Noma, also known as cancrum oris, is related to acatalasemia and pyuria, and has symptoms including oral manifestations An important gene associated with Noma is ARHGAP33 (Rho GTPase Activating Protein 33), and among its related pathways/superpathways are Signaling by GPCR and TGF-Beta Pathway. The drugs Estradiol valerate and Progesterone have been mentioned in the context of this disorder. Affiliated tissues include myeloid, heart and bone, and related phenotypes are cellular and homeostasis/metabolism

Wikipedia : 76 Noma is a rapidly progressive, polymicrobial, often gangrenous infection of the mouth or... more...

Related Diseases for Noma

Diseases related to Noma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 51)
# Related Disease Score Top Affiliating Genes
1 acatalasemia 11.0
2 pyuria 10.6 ALB CXCL8
3 sapho syndrome 10.5 CXCL8 IL18
4 acute cystitis 10.4 ALB CXCL8 IL18
5 visceral leishmaniasis 10.3 ALB CXCL8 IL18
6 chylothorax, congenital 10.3 ALB PTPN11
7 capillary leak syndrome 10.3 ALB CXCL8
8 aleutian mink disease 10.2 ALB NGFR
9 epulis 10.2 NGFR PGR
10 euthyroid sick syndrome 10.1 ALB POMC
11 gingivitis 10.1
12 stomatitis 10.1
13 fasciitis 10.0
14 necrotizing fasciitis 10.0
15 severe nonproliferative diabetic retinopathy 10.0 ALB INS
16 burns 10.0 ALB INS
17 ankylosis 10.0
18 sella turcica neoplasm 9.9 PGR POMC
19 tuberculum sellae meningioma 9.9 PGR POMC
20 neutropenia 9.9
21 acquired immunodeficiency syndrome 9.9
22 background diabetic retinopathy 9.9 ALB INS
23 tricuspid valve insufficiency 9.8 ALB PTPN11
24 syndrome of inappropriate antidiuretic hormone 9.8 ALB POMC
25 cyclic neutropenia 9.7
26 myeloperoxidase deficiency 9.7
27 combined immunodeficiency, x-linked 9.7
28 acute promyelocytic leukemia 9.7
29 leukemia, acute lymphoblastic 9.7
30 leukemia 9.7
31 severe combined immunodeficiency 9.7
32 lymphoblastic leukemia 9.7
33 myiasis 9.7
34 ecthyma 9.7
35 kwashiorkor 9.7
36 necrotizing ulcerative gingivitis 9.7
37 cheilitis 9.7
38 laryngitis 9.7
39 cerebrovascular disease 9.7
40 appendicitis 9.7
41 measles 9.7
42 scleredema adultorum 9.6 INS POMC
43 pituitary apoplexy 9.6 INS POMC
44 sheehan syndrome 9.5 INS POMC
45 reproductive system disease 9.4 CXCL8 INS PGR
46 hyperpituitarism 9.4 INS POMC
47 fetal erythroblastosis 9.3 ALB INS POMC
48 glucose metabolism disease 9.3 ALB INS POMC
49 urinary system disease 9.3 ALB INS POMC
50 acquired metabolic disease 9.3 ALB INS POMC

Graphical network of the top 20 diseases related to Noma:



Diseases related to Noma

Symptoms & Phenotypes for Noma

UMLS symptoms related to Noma:


oral manifestations

MGI Mouse Phenotypes related to Noma:

46 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.16 ALB ARHGAP1 IL18 INS MAPK7 NGFR
2 homeostasis/metabolism MP:0005376 10.1 ALB ARHGAP1 IL18 INS MAPK7 NGFR
3 cardiovascular system MP:0005385 10.08 INS MAPK7 NGFR PGR POMC PTPN11
4 adipose tissue MP:0005375 9.97 ARHGAP1 IL18 INS NGFR POMC PTPN11
5 integument MP:0010771 9.97 ARHGAP1 IL18 INS MAPK7 NGFR PGR
6 mortality/aging MP:0010768 9.96 ALB ARHGAP1 ARHGAP33 IL18 INS MAPK7
7 digestive/alimentary MP:0005381 9.91 ALB IL18 INS MAPK7 NGFR PTPN11
8 liver/biliary system MP:0005370 9.87 PTPN11 ALB ARHGAP1 INS NGFR POMC
9 muscle MP:0005369 9.76 ALB ARHGAP1 IL18 INS MAPK7 NGFR
10 nervous system MP:0003631 9.61 ARHGAP1 ARHGAP33 IL18 INS MAPK7 NGFR
11 renal/urinary system MP:0005367 9.1 MAPK7 NGFR POMC ALB ARHGAP1 INS

Drugs & Therapeutics for Noma

Drugs for Noma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 36)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Estradiol valerate Approved, Investigational, Vet_approved Phase 3 979-32-8
2
Progesterone Approved, Vet_approved Phase 3 57-83-0 5994
3
Estradiol Approved, Investigational, Vet_approved Phase 3 50-28-2 5757
4
Polyestradiol phosphate Approved Phase 3 28014-46-2
5
Alogliptin Approved Phase 3 850649-61-5 11450633
6
Darbepoetin alfa Approved, Investigational Phase 3 11096-26-7, 209810-58-2
7
Capecitabine Approved, Investigational Phase 3 154361-50-9 60953
8
Anastrozole Approved, Investigational Phase 3 120511-73-1 2187
9
Exemestane Approved, Investigational Phase 3 107868-30-4 60198
10
Letrozole Approved, Investigational Phase 3 112809-51-5 3902
11
Oxaliplatin Approved, Investigational Phase 3 61825-94-3 5310940 9887054 43805 6857599
12
Trastuzumab Approved, Investigational Phase 3 180288-69-1 9903
13
Lapatinib Approved March 2007, Investigational Phase 3 231277-92-2, 388082-78-8 208908 9941095
14 Progestins Phase 3
15 Contraceptive Agents Phase 3
16 Hormone Antagonists Phase 3
17 Angiogenesis Inhibitors Phase 3,Not Applicable
18 Hormones Phase 3
19 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
20 Estradiol 17 beta-cypionate Phase 3
21 Estradiol 3-benzoate Phase 3
22 Estrogens Phase 3
23
protease inhibitors Phase 3
24 Hematinics Phase 3
25 HIV Protease Inhibitors Phase 3
26 Dipeptidyl-Peptidase IV Inhibitors Phase 3
27 Hypoglycemic Agents Phase 3
28 Incretins Phase 3
29 Steroid Synthesis Inhibitors Phase 3
30 Estrogen Antagonists Phase 3
31 Protein Kinase Inhibitors Phase 3
32 Aromatase Inhibitors Phase 3
33 Antimetabolites Phase 3
34 Antimetabolites, Antineoplastic Phase 3
35
Ranibizumab Approved Not Applicable 347396-82-1 459903
36 Angiogenesis Modulating Agents Not Applicable

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 POPART'MUS: Prevention of Post Partum Relapses With Progestin and Estradiol in Multiple Sclerosis Unknown status NCT00127075 Phase 3 nomegestrol acetate;estradiol;placebo
2 Cardiovascular Outcomes Study of Alogliptin in Patients With Type 2 Diabetes and Acute Coronary Syndrome Completed NCT00968708 Phase 3 Alogliptin;Placebo
3 RED-HF™ Trial - Reduction of Events With Darbepoetin Alfa in Heart Failure Trial Completed NCT00358215 Phase 3 Darbepoetin alfa;Placebo
4 A Study to Evaluate Pazopanib as an Adjuvant Treatment for Localized Renal Cell Carcinoma (RCC) Active, not recruiting NCT01235962 Phase 3 pazopanib;placebo
5 A Study to Compare the Safety and Efficacy of an Aromatase Inhibitor in Combination With Lapatinib, Trastuzumab or Both for the Treatment of Hormone Receptor Positive, HER2+ Metastatic Breast Cancer Active, not recruiting NCT01160211 Phase 3 lapatinib;trastuzumab;Aromatase inhibitor;lapatinib
6 LOGiC - Lapatinib Optimization Study in ErbB2 (HER2) Positive Gastric Cancer: A Phase III Global, Blinded Study Designed to Evaluate Clinical Endpoints and Safety of Chemotherapy Plus Lapatinib Active, not recruiting NCT00680901 Phase 3 Lapatinib;Placebo;Capecitabine;Oxaliplatin
7 A Three-part Study of Eltrombopag in Thrombocytopenic Subjects With Myelodysplastic Syndromes or Acute Myeloid Leukemia Completed NCT01440374 Phase 2 eltrombopag;placebo
8 Development of Intravitreal Ranibizumab by Determining the Pathogenesis of Macular Edema With Retinal Vein Occlusion Unknown status NCT02169648 Not Applicable ranibizumab
9 Stroke Incidence and Risk Factors in a Tri-ethnic Region Completed NCT03266952
10 Fat Quality on Blood Lipids and Immune Response Completed NCT01679496 Not Applicable
11 Comparison of Non-nutritive Suck (NNS) Measures to Clinical Estimates of Suck and Feeding Readiness in Preterm Infants Completed NCT01069731
12 Evaluating Dysphagia in Neonates With CHD Recruiting NCT03045757
13 Supporting and Enhancing NICU Sensory Experiences (SENSE) Recruiting NCT03316547 Not Applicable
14 Japanese Idiopathic Interstitial Pneumonias Registry Recruiting NCT03041623

Search NIH Clinical Center for Noma

Cochrane evidence based reviews: noma

Genetic Tests for Noma

Anatomical Context for Noma

MalaCards organs/tissues related to Noma:

41
Myeloid, Heart, Bone

Publications for Noma

Articles related to Noma:

(show top 50) (show all 191)
# Title Authors Year
1
The Progress on Noma Disease and Its Surgical Treatment. ( 29538189 )
2018
2
Optimal Resource Allocation for NOMA-TDMA Scheme with I+-Fairness in Industrial Internet of Things. ( 29762506 )
2018
3
Evaluation of the Noma Disease Burden Within the Noma Belt. ( 29800992 )
2018
4
An unusual case of noma caused by Klebsiella pnuemoniae and its management. ( 29368993 )
2018
5
Experimental demonstration of bidirectional NOMA-OFDMA visible light communications. ( 28241638 )
2017
6
Worst-Case Energy Efficiency Maximization in a 5G Massive MIMO-NOMA System. ( 28927019 )
2017
7
Noma: Time to Address a Collective Moral Failure. ( 28115663 )
2017
8
Noma in an HIV infected patient in Guinea-Bissau: a case report. ( 28589415 )
2017
9
Noma in a patient with HIV. ( 28555591 )
2017
10
Noma as a complication of false teeth (Ebiino) extraction: a case report. ( 28412977 )
2017
11
Management of noma: practice competence and knowledge among healthcare workers in a rural district of Zambia. ( 28678680 )
2017
12
Acute necrotising gingivitis in young children from villages with and without noma in Niger and its association with sociodemographic factors, nutritional status and oral hygiene practices: results of a population-based survey. ( 29082004 )
2017
13
Face of Noma and Extreme Poverty: Development of an Economic Index Derivable From Health Data. ( 28582299 )
2017
14
Solution for error propagation in a NOMA-based VLC network: symmetric superposition coding. ( 29221021 )
2017
15
Cancrum oris (noma): An early sign of acute lymphoblastic leukemia relapse. ( 28799529 )
2017
16
Noma: Overview of a Neglected Disease and Human Rights Violation. ( 28093536 )
2017
17
Noma in a child with acute leukaemia: when the 'face of poverty' finds an ally. ( 26740267 )
2016
18
People living with facial disfigurement after having had noma disease: A systematic review of the literature. ( 26837690 )
2016
19
Facing noma. ( 27788987 )
2016
20
SERUM LEVELS OF FA^BROBLAST GROWTH FACTOR-23, OSTEOPROTEGERA^N AND RECEPTOR ACTA^VATOR OF NUCLEAR FACTOR KAPPA B LA^GAND (RANKL) A^N PATA^ENTS WA^H PROLACTA^NOMA. ( 27849387 )
2016
21
Noma Neonatorum From Multidrug-Resistant Pseudomonas aeruginosa: An Underestimated Threat? ( 26407438 )
2015
22
Noma: A disease of poverty presenting at an urban hospital in the United States. ( 27075129 )
2015
23
NOMA-GAP/ARHGAP33 regulates synapse development and autistic-like behavior in the mouse. ( 25869807 )
2015
24
A Review on Noma: A Recent Update. ( 26573028 )
2015
25
Cancrum Oris (Noma): The Role of Nutrition in Management. ( 28053869 )
2015
26
Enabling Virtual Screening of Potent and Safer Antimicrobial Agents Against Noma: mtk-QSBER Model for Simultaneous Prediction of Antibacterial Activities and ADMET Properties. ( 25769968 )
2015
27
Serum soluble RAGE levels and carotid atherosclerosis: the Northern Manhattan Study (NOMAS). ( 25744702 )
2015
28
Bony fusion of the maxilla and mandible as a sequelae of noma: A rare case report. ( 26389063 )
2015
29
Noma: neglected, forgotten and a human rights issue. ( 25609756 )
2015
30
Apnoeic oxygenation in noma patients. ( 25959184 )
2015
31
Paul Tessier facial reconstruction in 1970 Iran, a series of post-noma defects. ( 25817742 )
2015
32
Noma affected children from niger have distinct oral microbial communities based on high-throughput sequencing of 16S rRNA gene fragments. ( 25474262 )
2014
33
Acute gangrenous gingivitis--early stage noma. ( 24825288 )
2014
34
Noma and Cervicofacial Necrotizing Fasciitis: Clinicopathological Differentiation and an Illustrative Case Report of Noma. ( 24304357 )
2014
35
Noma (cancrum oris) in the South African context. ( 23647162 )
2014
36
Plasma FGF23 and the risk of stroke: the Northern Manhattan Study (NOMAS). ( 24706015 )
2014
37
A noma case study. ( 25668873 )
2014
38
Noma (cancrum oris): a report of a case in a young AIDS patient with a review of the pathogenesis. ( 22907664 )
2013
39
Noma in an immunocompromised patient. ( 24192747 )
2013
40
Special article: airway management in reconstructive surgery for noma (cancrum oris). ( 23733840 )
2013
41
Microarray analysis of microbiota of gingival lesions in noma patients. ( 24086784 )
2013
42
Noma neonatorum. ( 23667229 )
2013
43
Risk factors for noma disease: a 6-year, prospective, matched case-control study in Niger. ( 25104163 )
2013
44
Noma: a neglected enigma. ( 25104148 )
2013
45
Neocortical dendritic complexity is controlled during development by NOMA-GAP-dependent inhibition of Cdc42 and activation of cofilin. ( 22810622 )
2012
46
Bacterial diversity in oral samples of children in niger with acute noma, acute necrotizing gingivitis, and healthy controls. ( 22413030 )
2012
47
First experiences with simultaneous skeletal and soft tissue reconstruction of noma-related facial defects. ( 21780014 )
2012
48
Gillies fan flap for the reconstruction of an upper lip defect caused by noma: case presentation. ( 23674921 )
2012
49
Noma in an Afghani child: a case report. ( 22381363 )
2012
50
Noma-like lesion in a patient with acute promyelocytic leukemia. ( 23049328 )
2011

Variations for Noma

Expression for Noma

Search GEO for disease gene expression data for Noma.

Pathways for Noma

Pathways related to Noma according to GeneCards Suite gene sharing:

(show all 20)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.98 ARHGAP1 ARHGAP33 CDC42 CXCL8 INS MAPK7
2
Show member pathways
13.15 CDC42 CXCL8 IL18 INS MAPK7 NGFR
3
Show member pathways
12.76 CDC42 CXCL8 IL18 MAPK7 NGFR PTN
4
Show member pathways
12.53 CDC42 INS NGFR PTPN11
5
Show member pathways
12.51 CDC42 MAPK7 NGFR PTPN11
6
Show member pathways
12.26 ARHGAP33 INS MAPK7 PTPN11
7
Show member pathways
12.18 CDC42 CXCL8 INS PTPN11
8
Show member pathways
11.93 CDC42 MAPK7 NGFR
9 11.85 ALB INS NGFR
10 11.8 ARHGAP1 CDC42 MAPK7
11 11.78 CDC42 CXCL8 NGFR
12 11.74 CXCL8 IL18 POMC
13 11.72 CDC42 MAPK7 PTPN11
14
Show member pathways
11.67 CXCL8 IL18 NGFR PTN PTPN11
15 11.6 CXCL8 IL18 POMC
16 11.51 CDC42 CXCL8 IL18
17 11.42 CDC42 MAPK7 NGFR PTPN11
18
Show member pathways
11.28 CDC42 NGFR PTPN11
19 10.9 IL18 PGR
20 10.03 CXCL8 POMC PTN

GO Terms for Noma

Cellular components related to Noma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein-containing complex GO:0032991 9.02 ALB ARHGAP33 CDC42 PTN PTPN11

Biological processes related to Noma according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 cell-cell signaling GO:0007267 9.71 IL18 INS PGR POMC
2 positive regulation of protein kinase B signaling GO:0051897 9.7 IL18 INS PTPN11
3 regulation of small GTPase mediated signal transduction GO:0051056 9.67 ARHGAP1 ARHGAP33 CDC42
4 cytokine-mediated signaling pathway GO:0019221 9.67 CXCL8 IL18 POMC PTPN11
5 small GTPase mediated signal transduction GO:0007264 9.63 ARHGAP1 ARHGAP33 CDC42
6 positive regulation of protein localization to nucleus GO:1900182 9.51 INS NGFR
7 positive regulation of glucose import in response to insulin stimulus GO:2001275 9.48 INS PTPN11
8 neurotrophin TRK receptor signaling pathway GO:0048011 9.43 NGFR PTPN11
9 regulation of signaling receptor activity GO:0010469 9.35 CXCL8 IL18 INS POMC PTN
10 Rho protein signal transduction GO:0007266 9.33 ARHGAP1 CDC42 NGFR
11 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway GO:1902176 9.32 INS MAPK7
12 neutrophil activation GO:0042119 9.26 CXCL8 IL18
13 glucose homeostasis GO:0042593 8.92 INS NGFR POMC PTPN11

Molecular functions related to Noma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 insulin receptor binding GO:0005158 8.62 INS PTPN11

Sources for Noma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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