Aliases & Classifications for Nominal Aphasia

MalaCards integrated aliases for Nominal Aphasia:

Name: Nominal Aphasia 12 15
Anomia 12 43 71
Anomic Aphasia 12 74

Classifications:



External Ids:

Disease Ontology 12 DOID:4541
MeSH 43 D000849
NCIt 49 C34386
SNOMED-CT 67 10325006
UMLS 71 C0003113

Summaries for Nominal Aphasia

Disease Ontology : 12 An agnosia that involves a severe problem with recalling words or names.

MalaCards based summary : Nominal Aphasia, also known as anomia, is related to semantic dementia and frontotemporal lobar degeneration with tdp43 inclusions, grn-related, and has symptoms including scanning speech and other symbolic dysfunction. An important gene associated with Nominal Aphasia is GRN (Granulin Precursor), and among its related pathways/superpathways are Synthesis of PC and Neurotransmitter Clearance In The Synaptic Cleft. The drugs tannic acid and Topiramate have been mentioned in the context of this disorder. Affiliated tissues include brain, temporal lobe and testes, and related phenotypes are growth/size/body region and mortality/aging

Wikipedia : 74 Anomic aphasia (also known as dysnomia, nominal aphasia, and amnesic aphasia) is a mild, fluent type of... more...

Related Diseases for Nominal Aphasia

Diseases related to Nominal Aphasia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 123)
# Related Disease Score Top Affiliating Genes
1 semantic dementia 31.6 TARDBP MAPT GRN CHMP2B C9orf72 APOE
2 frontotemporal lobar degeneration with tdp43 inclusions, grn-related 31.5 MAPT GRN
3 tactile agnosia 30.6 TARDBP CBSL
4 apraxia 30.2 MAPT GRN C9orf72 APOE
5 dysgraphia 30.2 TARDBP MAPT GRN CHMP2B CBSL C9orf72
6 binswanger's disease 29.8 MAPT APOE ACHE
7 amnestic disorder 29.8 BCHE APOE ACHE
8 vascular dementia 29.5 MAPT BCHE APOE ACHE
9 alexia 29.4 MTSS2 MAPT GRN CBSL BCHE APOE
10 ideomotor apraxia 29.3 TARDBP MAPT GRN CBSL BCHE ADAMTS2
11 agraphia 29.0 TARDBP PRSS3 MTSS2 MAPT GRN CBSL
12 visual agnosia 28.8 PRSS3 MTSS2 MAPT GRN APOE ADAMTS2
13 associative agnosia 28.7 VCP TARDBP MAPT GRN CHMP2B C9orf72
14 alzheimer disease 28.5 VCP TARDBP MAPT GRN C9orf72 BCHE
15 pick disease of brain 28.3 VCP TARDBP MAPT GRN FUS CHMP2B
16 aphasia 27.9 VCP TARDBP PRSS3 MAPT GRN FUS
17 frontotemporal dementia 27.5 VCP TARDBP MAPT GRN FUS CHMP2B
18 dementia 27.3 VCP TARDBP MAPT GRN FUS CHMP2B
19 speech and communication disorders 26.2 VCP TARDBP PRSS3 MAPT GRN FUS
20 gait apraxia 10.4 GRN CBSL
21 akinetic mutism 10.3 TARDBP MAPT
22 postencephalitic parkinson disease 10.3 TARDBP MAPT
23 amyotrophic lateral sclerosis, juvenile, with dementia 10.3 VCP C9orf72
24 amyotrophic lateral sclerosis type 15 10.3 CHMP2B C9orf72
25 amyotrophic lateral sclerosis 19 10.3 TARDBP C9orf72
26 paraphilia disorder 10.3 GRN ADAMTS2
27 echolalia 10.3 MAPT GRN C9orf72
28 pseudobulbar palsy 10.2 TARDBP CHMP2B C9orf72
29 posterior cortical atrophy 10.2 MAPT APOE
30 corticobasal degeneration 10.2 TARDBP MAPT
31 myositis 10.2 VCP TARDBP MAPT
32 arteriovenous malformation 10.2
33 muscular atrophy 10.2 TARDBP FUS C9orf72
34 progressive bulbar palsy 10.1 TARDBP FUS C9orf72
35 kohlschutter-tonz syndrome 10.1 MAPT APOE
36 agnosia 10.1
37 herpes simplex 10.1
38 herpes simplex encephalitis 10.1
39 amyotrophic lateral sclerosis 10 with or without frontotemporal dementia 10.1 TARDBP FUS C9orf72
40 amyotrophic lateral sclerosis type 6 10.1 TARDBP FUS C9orf72
41 amyotrophic lateral sclerosis 4, juvenile 10.1 TARDBP FUS C9orf72
42 topographical agnosia 10.1 CBSL BCHE
43 spinal and bulbar muscular atrophy, x-linked 1 10.1 TARDBP FUS C9orf72
44 amyotrophic lateral sclerosis 12 10.1 TARDBP FUS CHMP2B
45 finger agnosia 10.1 MTSS2 CBSL ADAMTS2
46 spinocerebellar ataxia 2 10.1 TARDBP FUS C9orf72
47 amyotrophic lateral sclerosis 18 10.1 FUS CHMP2B
48 amyotrophic lateral sclerosis 11 10.1 TARDBP FUS CHMP2B
49 autotopagnosia 10.1
50 chronic meningitis 10.1

Graphical network of the top 20 diseases related to Nominal Aphasia:



Diseases related to Nominal Aphasia

Symptoms & Phenotypes for Nominal Aphasia

UMLS symptoms related to Nominal Aphasia:


scanning speech, other symbolic dysfunction

MGI Mouse Phenotypes related to Nominal Aphasia:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.07 ACHE ADAMTS2 APOE C9orf72 CBSL GRN
2 mortality/aging MP:0010768 10 ACHE APOE BCHE C9orf72 CBSL CHMP2B
3 integument MP:0010771 9.87 ADAMTS2 APOE C9orf72 CBSL GRN MAPT
4 muscle MP:0005369 9.63 ACHE APOE CBSL MAPT TARDBP VCP
5 nervous system MP:0003631 9.61 ACHE APOE C9orf72 CBSL CHMP2B GRN
6 no phenotypic analysis MP:0003012 9.1 ACHE APOE C9orf72 GRN MAPT TARDBP

Drugs & Therapeutics for Nominal Aphasia

Drugs for Nominal Aphasia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 32)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
tannic acid Approved Phase 4 1401-55-4
2
Topiramate Approved Phase 4 97240-79-4 5284627
3
Acetylcholine Approved, Investigational Phase 4 51-84-3 187
4
Benzocaine Approved, Investigational Phase 4 1994-09-7, 94-09-7 2337
5 abobotulinumtoxinA Phase 4
6 Hypoglycemic Agents Phase 4
7 Acetylcholine Release Inhibitors Phase 4
8 Neuromuscular Agents Phase 4
9 Anticonvulsants Phase 4
10 Botulinum Toxins Phase 4
11 Botulinum Toxins, Type A Phase 4
12
Donepezil Approved Phase 3 120014-06-4 3152
13 Neurotransmitter Agents Phase 3
14 Cholinergic Agents Phase 3
15 Nootropic Agents Phase 3
16 Cholinesterase Inhibitors Phase 3
17
Corticosterone Experimental Phase 1 50-22-6 5753
18 Fluorodeoxyglucose F18 Phase 1
19 Deoxyglucose Phase 1
20
Dopamine Approved 51-61-6, 62-31-7 681
21
Benserazide Approved, Investigational 322-35-0
22
Levodopa Approved 59-92-7 6047
23
Cefpodoxime Approved, Vet_approved 80210-62-4, 82619-04-3 6335986
24 Sympathomimetics
25 Dopamine Agents
26 Dopamine agonists
27 Antiparkinson Agents
28 Autonomic Agents
29 Protective Agents
30 Cefpodoxime proxetil
31 Anesthetics
32 Central Nervous System Depressants

Interventional clinical trials:

(show all 32)
# Name Status NCT ID Phase Drugs
1 A Randomized, Pilot Study to Evaluate the Tolerability of OnabotulinumtoxinA Plus Topiramate vs. OnabotulinumtoxinA Plus Placebo and Long Term Effect of Treatment on Cognitive Efficiency and Continuation of Care Completed NCT01700387 Phase 4 onabotulinumtoxinA;Topiramate;Placebo
2 Effects of Combining Donepezil, Intensive Language Rehabilitation and Transcranial Direct Current Stimulation on Language Recovery and Brain Reorganization in Chronic Post-stroke Aphasia Recruiting NCT04134416 Phase 3 Donepezil
3 Chronic Aphasia - Improved by Intensive Training and Electrical Brain Unknown status NCT01221779 Phase 2
4 Chronic Aphasia - Improved by Intensive Training and Electrical Brain Stimulation (CATS) Unknown status NCT01924702 Phase 2
5 Targeted Transcranial Electrotherapy for Stroke Rehabilitation - Exploratory Trial on Aphasia Recruiting NCT02540109 Phase 2
6 High Definition-transcranial Direct Current Stimulation (HD-tDCS) for Stroke Rehabilitation Completed NCT01651884 Phase 1
7 Treatment of Language and Memory in Patients With Alzheimer's Disease: A Comparison Between Drug Therapy and Drug Therapy Plus Behavioral Intervention Completed NCT00593372 Phase 1
8 PiB PET Scanning in Speech and Language Based Dementias Completed NCT01623284 Phase 1 C-11 PiB;F-18 FDG
9 Overcoming Learned Non-Use in Chronic Aphasia: Behavioral, fMRI and QoL Outcomes Unknown status NCT02012374
10 A Prospective, Controlled Study of Rehabilitation of Anomia in Aphasia Completed NCT02153710
11 Effect of Dopaminergic Medication on Recovery of Aphasia Completed NCT00941265 levodopa and benserazide;placebo
12 Learning Paradigms in Aphasia Rehabilitation Completed NCT00494520
13 The Center for the Neurobiology of Language Recovery (CNLR) Completed NCT01927302
14 Brain Connectivity Supporting Language Recovery in Aphasia Completed NCT02416856
15 Slowing Language Decline in Progressive Aphasia Through Language Rehabilitation: Treatment and Neuroimaging Study Completed NCT00957710
16 Communication Outcomes for Naming Treatments in Aphasia Completed NCT00764400
17 Improving Word Repetition Training Using Classical Conditioning With a Computer Based Telemedicine Approach: Evidence From a Study on 12 Person With Chronic Aphasia. Completed NCT03381313
18 Language Assessment and Treatment Following Acquired Brain Injury Completed NCT03320954
19 Role of the Right Brain in Recovery of Language Function in Chronic Stroke Completed NCT00076479
20 Preventing Language Decline in Dementia Completed NCT02541097
21 Does Inner Speech Improve Access to Overt Speech in Aphasia Following Stroke? An fMRI Study Utilising Computerised Rehabilitation Software. Completed NCT01928602
22 Effects of a Combination of Transcranial Direct Stimulation (tDCS) and Behavioral Intervention in Non-fluent Aphasia Completed NCT02226796
23 Finding the Right Words in Neurogenic Communication Disorders: Naming of Objects and Actions, Communicative Strategies in Conversation and Effects of Training Recruiting NCT03568760
24 Mechanisms Underlying Spoken Language Production: Facilitating Frontal Brain Networks Following Aphasic Stroke Recruiting NCT04138433
25 Treatment Outcomes and Brain Mechanisms Associated With Non-Invasive Neuromodulation in Post-Stroke Aphasia Recruiting NCT03929432
26 Rehabilitation and Prophylaxis of Anomia in Primary Progressive Aphasia Recruiting NCT02675270
27 Rehabilitating and Decelerating Language Loss in Primary Progressive Aphasia With Transcranial Direct Current Stimulation (tDCS) Plus Language Therapy Recruiting NCT03728582
28 Application of Graph Theory to Both Resting-state and Task-based fMRI Data to Uncover Brain-behavior Relationships Related to Therapy Outcomes in Aphasia Recruiting NCT03550092
29 (C-STAR) Center for the Study of Aphasia Recovery Modeling Treated Recovery From Aphasia Recruiting NCT03416738
30 Prospective Study of Awake Intraoperative Language Mapping and Construction of Chinese Probabilistic Map Based on Direct Electrical Stimulation Not yet recruiting NCT03641391
31 Voice Adaptive Training for Adults With Aphasia Not yet recruiting NCT04108364
32 Pairing Word Retrieval and Physical Endurance Tasks to Treat Anomia Withdrawn NCT03326687

Search NIH Clinical Center for Nominal Aphasia

Cochrane evidence based reviews: anomia

Genetic Tests for Nominal Aphasia

Anatomical Context for Nominal Aphasia

MalaCards organs/tissues related to Nominal Aphasia:

40
Brain, Temporal Lobe, Testes, Colon, Eye, Cortex, Parietal Lobe

Publications for Nominal Aphasia

Articles related to Nominal Aphasia:

(show top 50) (show all 695)
# Title Authors PMID Year
1
A description of verbal and gestural communication during postictal aphasia. 61
31759317 2020
2
Empirical Evaluation of Computer-Adaptive Alternate Short Forms for the Assessment of Anomia Severity. 61
31851861 2020
3
[Financial fraud and health: a qualitative approach]. 61
31964535 2020
4
TDQ-30-A New Color Picture-Naming Test for the Diagnostic of Mild Anomia: Validation and Normative Data in Quebec French Adults and Elderly. 61
31792492 2019
5
The Influence of Phonomotor Treatment on Word Retrieval: Insights From Naming Errors. 61
31682780 2019
6
Evidence for indirect loss of significance effects on violent extremism: The potential mediating role of anomia. 61
31452219 2019
7
Phonomotor Versus Semantic Feature Analysis Treatment for Anomia in 58 Persons With Aphasia: A Randomized Controlled Trial. 61
31805247 2019
8
Correlates of anomia in non-semantic variants of primary progressive aphasia converge over time. 61
31325799 2019
9
Long-Term maintenance of anomia treatment effects in primary progressive aphasia. 61
29380657 2019
10
Remembering a name: Neuropsychological validity studies and a computer proposal for detection of anomia. 61
31844500 2019
11
Four cases of natalizumab-related PML: a less severe course in extended interval dosing? 61
31175467 2019
12
Expected performance of Quebec-French older adults on the Batterie Rapide de Dénomination (BARD). 61
31544520 2019
13
Naming difficulties after thyroid stimulating hormone suppression therapy in patients with differentiated thyroid carcinoma: a prospective cohort study. 61
31056722 2019
14
The Link Between Verbal Short-Term Memory and Anomia Treatment Gains. 61
31112652 2019
15
A Retrospective Study of Long-Term Improvement on the Boston Naming Test. 61
31419151 2019
16
Comparing the effects of clinician and caregiver-administered lexical retrieval training for progressive anomia. 61
28662598 2019
17
Effect Sizes in Single-Case Aphasia Studies: A Comparative, Autocorrelation-Oriented Analysis. 61
31260377 2019
18
Enhancing the Efficiency of Confrontation Naming Assessment for Aphasia Using Computer Adaptive Testing. 61
31158037 2019
19
A machine-learned analysis suggests non-redundant diagnostic information in olfactory subtests. 61
30671562 2019
20
Self-reported inner speech relates to phonological retrieval ability in people with aphasia. 61
30921682 2019
21
'What's cooking?' A comparison of an activity-oriented and a table-top programme of therapy on the language performance of people with aphasia. 61
30548111 2019
22
Language Mapping of Hindi and English in a Bilingual Patient During Resection of a Right Frontal Glioma. 61
30735861 2019
23
Functional compensation of the left inferior longitudinal fasciculus for picture naming. 61
29879863 2019
24
Morphometric correlates of anomia in patients with small left temporopolar lesions. 61
31059211 2019
25
Selection for sentence generation in the context of severe anomia: A case series of left temporal patients. 61
30608030 2019
26
Case of right hemispatial neglect and transcortical sensory aphasia following left occipitotemporoparietal glioblastoma resection. 61
30987454 2019
27
Storage, Degradation, and New Connectivity of Face-Related Semantic Memory in Alzheimer's Disease. 61
31007428 2019
28
Clinical and neuroimaging investigations of language disturbance in frontotemporal dementia-motor neuron disease patients. 61
30707358 2019
29
Analysis of naming processing stages in patients with mild Alzheimer. 61
31030561 2019
30
Validity and features of spontaneous speech in acute aphasia as evaluated with the Brief Aphasia Evaluation: is fluent aphasia more severe than nonfluent aphasia? 61
30843923 2019
31
Efficacy of a self-administered treatment using a smart tablet to improve functional vocabulary in post-stroke aphasia: a case-series study. 61
30426650 2019
32
Effects of Phonomotor Treatment on discourse production. 61
30956383 2019
33
Evaluating Personal Stroke Narratives from Bilingual Greek-English Immigrants with Aphasia. 61
31085928 2019
34
Maximizing the Treatment Benefit of tDCS in Neurodegenerative Anomia. 61
31824242 2019
35
Naming and Knowing Revisited: Eyetracking Correlates of Anomia in Progressive Aphasia. 61
31680908 2019
36
Modified semantic feature analysis for anomia: a single case study. 61
30907157 2019
37
Code-switching in multilinguals with dementia: patterns across speech contexts. 61
31017031 2019
38
Anomia for musical entities. 61
31031508 2019
39
[On the Issue of Evolution of the Concept of "Public Health"]. 61
30790482 2019
40
Evidence for a functional specialization of ventral anterior temporal lobe for language. 61
30165255 2018
41
Cognitive consequences of the left-right asymmetry of atrophy in semantic dementia. 61
29289335 2018
42
[FROM THEORY TO THE CLINIC - IS IT POSSIBLE TO DETECT DIFFERENT TYPES OF ANOMIA ACCORDING TO THE LEXICAL RETRIEVAL MODEL?] 61
30221856 2018
43
Treatment for spoken and written word retrieval in the semantic variant of primary progressive aphasia. 61
30198389 2018
44
[18F]THK-5351 PET imaging in early-stage semantic variant primary progressive aphasia: a report of two cases and a literature review. 61
30089453 2018
45
Treatment for Lexical Retrieval Impairments in Primary Progressive Aphasia: A Research Update with Implications for Clinical Practice. 61
29933491 2018
46
Typicality-based semantic treatment for anomia results in multiple levels of generalisation. 61
30027828 2018
47
A lexical semantic hub for heteromodal naming in middle fusiform gyrus. 61
29860298 2018
48
The eyes reveal uncertainty about object distinctions in semantic variant primary progressive aphasia. 61
29753915 2018
49
Frontotemporal stimulation modulates semantically-guided visual search during confrontation naming: A combined tDCS and eye tracking investigation. 61
29655024 2018
50
Parietal association deficits in patients harboring parietal lobe gliomas: a prospective study. 61
29726775 2018

Variations for Nominal Aphasia

Expression for Nominal Aphasia

Search GEO for disease gene expression data for Nominal Aphasia.

Pathways for Nominal Aphasia

GO Terms for Nominal Aphasia

Cellular components related to Nominal Aphasia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 dendrite GO:0030425 9.62 MAPT FUS C9orf72 APOE
2 extracellular region GO:0005576 9.28 VCP PRSS3 MAPT GRN C9orf72 BCHE
3 synaptic cleft GO:0043083 9.26 APOE ACHE
4 main axon GO:0044304 9.16 MAPT C9orf72
5 cytoplasmic stress granule GO:0010494 9.13 VCP TARDBP C9orf72

Biological processes related to Nominal Aphasia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 autophagy GO:0006914 9.5 VCP CHMP2B C9orf72
2 regulation of synapse organization GO:0050807 9.26 VCP APOE
3 stress granule assembly GO:0034063 9.16 MAPT C9orf72
4 gene expression GO:0010467 8.96 TARDBP FUS
5 amyloid precursor protein metabolic process GO:0042982 8.62 APOE ACHE

Molecular functions related to Nominal Aphasia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.7 VCP TARDBP MAPT FUS BCHE APOE
2 amyloid-beta binding GO:0001540 9.5 BCHE APOE ACHE
3 lipoprotein particle binding GO:0071813 9.26 MAPT APOE
4 cholinesterase activity GO:0004104 8.96 BCHE ACHE
5 acetylcholinesterase activity GO:0003990 8.62 BCHE ACHE

Sources for Nominal Aphasia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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