Aliases & Classifications for Nominal Aphasia

MalaCards integrated aliases for Nominal Aphasia:

Name: Nominal Aphasia 12 15
Anomia 12 44 72
Anomic Aphasia 12 75

Classifications:



External Ids:

Disease Ontology 12 DOID:4541
MeSH 44 D000849
NCIt 50 C34386
SNOMED-CT 68 10325006
UMLS 72 C0003113

Summaries for Nominal Aphasia

Disease Ontology : 12 An agnosia that involves a severe problem with recalling words or names.

MalaCards based summary : Nominal Aphasia, also known as anomia, is related to pick disease of brain and frontotemporal lobar degeneration with tdp43 inclusions, grn-related, and has symptoms including scanning speech and other symbolic dysfunction. An important gene associated with Nominal Aphasia is GRN (Granulin Precursor), and among its related pathways/superpathways is Cytoskeletal Signaling. The drugs tannic acid and Acetylcholine have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and temporal lobe, and related phenotypes are behavior/neurological and cellular

Wikipedia : 75 Anomic aphasia (also known as dysnomia, nominal aphasia, and amnesic aphasia) is a mild, fluent type of... more...

Related Diseases for Nominal Aphasia

Diseases related to Nominal Aphasia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 67)
# Related Disease Score Top Affiliating Genes
1 pick disease of brain 31.3 TARDBP MAPT GRN
2 frontotemporal lobar degeneration with tdp43 inclusions, grn-related 30.9 MAPT GRN
3 semantic dementia 30.7 TARDBP MAPT GRN CHMP2B
4 apraxia 30.4 MAPT GRN
5 ideomotor apraxia 30.3 MAPT GRN
6 associative agnosia 30.2 TARDBP GRN
7 agraphia 30.1 TARDBP MAPT GRN
8 aphasia 29.8 MAPT GRN CHMP2B
9 speech and communication disorders 29.8 TARDBP MAPT GRN
10 alzheimer disease 29.3 TARDBP MAPT GRN
11 frontotemporal dementia 28.5 TARDBP MAPT GRN CHMP2B
12 dementia 28.5 TARDBP MAPT GRN CHMP2B
13 alexia 10.5
14 dysgraphia 10.4
15 amnestic disorder 10.3
16 vascular dementia 10.2
17 arteriovenous malformation 10.2
18 phonagnosia 10.2 TARDBP GRN
19 agnosia 10.1
20 herpes simplex encephalitis 10.1
21 writing disorder 10.1 TARDBP GRN
22 autotopagnosia 10.1
23 chronic meningitis 10.1
24 meningoencephalitis 10.1
25 neurosarcoidosis 10.1
26 echolalia 10.0 MAPT GRN
27 perry syndrome 10.0 TARDBP GRN
28 papillomatosis, confluent and reticulated 10.0
29 schizophrenia 10.0
30 ocular motor apraxia 10.0
31 branchiootic syndrome 1 10.0
32 tactile agnosia 10.0
33 visual agnosia 10.0
34 cerebral artery occlusion 10.0
35 reading disorder 10.0
36 papilledema 10.0
37 temporal lobe epilepsy 10.0
38 dyslexia 10.0
39 acute disseminated encephalomyelitis 10.0
40 herpes simplex 10.0
41 intracranial hypertension 10.0
42 encephalitis 10.0
43 47,xyy 10.0
44 binswanger's disease 10.0
45 glioma 10.0
46 logopenic progressive aphasia 10.0
47 head injury 10.0
48 headache 10.0
49 traumatic brain injury 10.0
50 glial tumor 10.0

Graphical network of the top 20 diseases related to Nominal Aphasia:



Diseases related to Nominal Aphasia

Symptoms & Phenotypes for Nominal Aphasia

UMLS symptoms related to Nominal Aphasia:


scanning speech, other symbolic dysfunction

MGI Mouse Phenotypes related to Nominal Aphasia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.55 DES GRASP GRN MAPT TARDBP
2 cellular MP:0005384 9.35 DES GRASP GRN MAPT TARDBP
3 nervous system MP:0003631 9.02 CHMP2B GRASP GRN MAPT TARDBP

Drugs & Therapeutics for Nominal Aphasia

Drugs for Nominal Aphasia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 31)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
tannic acid Approved Phase 4 1401-55-4
2
Acetylcholine Approved, Investigational Phase 4 51-84-3 187
3
Topiramate Approved Phase 4 97240-79-4 5284627
4
Benzocaine Approved, Investigational Phase 4 94-09-7, 1994-09-7 2337
5 Neurotransmitter Agents Phase 4
6 Peripheral Nervous System Agents Phase 4
7 abobotulinumtoxinA Phase 4
8 Neuromuscular Agents Phase 4
9 Cholinergic Agents Phase 4
10 Acetylcholine Release Inhibitors Phase 4
11 Hypoglycemic Agents Phase 4
12 Anticonvulsants Phase 4
13 Botulinum Toxins Phase 4
14 Botulinum Toxins, Type A Phase 4
15
Corticosterone Experimental Phase 1 50-22-6 5753
16 Fluorodeoxyglucose F18 Phase 1
17 Radiopharmaceuticals Phase 1
18 Deoxyglucose Phase 1
19
Dopamine Approved 51-61-6, 62-31-7 681
20
Levodopa Approved 59-92-7 6047
21
Benserazide Approved, Investigational 322-35-0
22
Cefpodoxime Approved, Vet_approved 80210-62-4, 82619-04-3 6335986
23 Sympathomimetics
24 Dopamine Agents
25 Cardiotonic Agents
26 Dopamine agonists
27 Antiparkinson Agents
28 Protective Agents
29 Autonomic Agents
30 Cefpodoxime proxetil
31 Anesthetics

Interventional clinical trials:

(show all 29)
# Name Status NCT ID Phase Drugs
1 A Randomized, Pilot Study to Evaluate the Tolerability of OnabotulinumtoxinA Plus Topiramate vs. OnabotulinumtoxinA Plus Placebo and Long Term Effect of Treatment on Cognitive Efficiency and Continuation of Care Completed NCT01700387 Phase 4 onabotulinumtoxinA;Topiramate;Placebo
2 Chronic Aphasia - Improved by Intensive Training and Electrical Brain Unknown status NCT01221779 Phase 2
3 Chronic Aphasia - Improved by Intensive Training and Electrical Brain Stimulation (CATS) Unknown status NCT01924702 Phase 2
4 Targeted Transcranial Electrotherapy for Stroke Rehabilitation - Exploratory Trial on Aphasia Recruiting NCT02540109 Phase 2
5 High Definition-transcranial Direct Current Stimulation (HD-tDCS) for Stroke Rehabilitation Completed NCT01651884 Phase 1
6 Treatment of Language and Memory in Patients With Alzheimer's Disease: A Comparison Between Drug Therapy and Drug Therapy Plus Behavioral Intervention Completed NCT00593372 Phase 1
7 PiB PET Scanning in Speech and Language Based Dementias Completed NCT01623284 Phase 1 C-11 PiB;F-18 FDG
8 Overcoming Learned Non-Use in Chronic Aphasia: Behavioral, fMRI and QoL Outcomes Unknown status NCT02012374
9 A Prospective, Controlled Study of Rehabilitation of Anomia in Aphasia Completed NCT02153710
10 Effect of Dopaminergic Medication on Recovery of Aphasia Completed NCT00941265 levodopa and benserazide;placebo
11 Learning Paradigms in Aphasia Rehabilitation Completed NCT00494520
12 Brain Connectivity Supporting Language Recovery in Aphasia Completed NCT02416856
13 Slowing Language Decline in Progressive Aphasia Through Language Rehabilitation: Treatment and Neuroimaging Study Completed NCT00957710
14 Communication Outcomes for Naming Treatments in Aphasia Completed NCT00764400
15 Improving Word Repetition Training Using Classical Conditioning With a Computer Based Telemedicine Approach: Evidence From a Study on 12 Person With Chronic Aphasia. Completed NCT03381313
16 Role of the Right Brain in Recovery of Language Function in Chronic Stroke Completed NCT00076479
17 Preventing Language Decline in Dementia Completed NCT02541097
18 Does Inner Speech Improve Access to Overt Speech in Aphasia Following Stroke? An fMRI Study Utilising Computerised Rehabilitation Software. Completed NCT01928602
19 Effects of a Combination of Transcranial Direct Stimulation (tDCS) and Behavioral Intervention in Non-fluent Aphasia Completed NCT02226796
20 Finding the Right Words in Neurogenic Communication Disorders: Naming of Objects and Actions, Communicative Strategies in Conversation and Effects of Training Recruiting NCT03568760
21 Rehabilitation and Prophylaxis of Anomia in Primary Progressive Aphasia Recruiting NCT02675270
22 Rehabilitating and Decelerating Language Loss in Primary Progressive Aphasia With Transcranial Direct Current Stimulation (tDCS) Plus Language Therapy Recruiting NCT03728582
23 Application of Graph Theory to Both Resting-state and Task-based fMRI Data to Uncover Brain-behavior Relationships Related to Therapy Outcomes in Aphasia Recruiting NCT03550092
24 (C-STAR) Center for the Study of Aphasia Recovery Modeling Treated Recovery From Aphasia Recruiting NCT03416738
25 The Center for the Neurobiology of Language Recovery (CNLR) Active, not recruiting NCT01927302
26 Language Assessment and Treatment Following Acquired Brain Injury Enrolling by invitation NCT03320954
27 Treatment Outcomes and Brain Mechanisms Associated With Non-Invasive Neuromodulation in Post-Stroke Aphasia Not yet recruiting NCT03929432
28 Prospective Study of Awake Intraoperative Language Mapping and Construction of Chinese Probabilistic Map Based on Direct Electrical Stimulation Not yet recruiting NCT03641391
29 Pairing Word Retrieval and Physical Endurance Tasks to Treat Anomia Withdrawn NCT03326687

Search NIH Clinical Center for Nominal Aphasia

Cochrane evidence based reviews: anomia

Genetic Tests for Nominal Aphasia

Anatomical Context for Nominal Aphasia

MalaCards organs/tissues related to Nominal Aphasia:

41
Brain, Testes, Temporal Lobe, Eye, Cortex, Parietal Lobe, Thalamus

Publications for Nominal Aphasia

Articles related to Nominal Aphasia:

(show top 50) (show all 684)
# Title Authors PMID Year
1
The Link Between Verbal Short-Term Memory and Anomia Treatment Gains. 38
31112652 2019
2
A Retrospective Study of Long-Term Improvement on the Boston Naming Test. 38
31419151 2019
3
Naming difficulties after thyroid stimulating hormone suppression therapy in patients with differentiated thyroid carcinoma: a prospective cohort study. 38
31056722 2019
4
Comparing the effects of clinician and caregiver-administered lexical retrieval training for progressive anomia. 38
28662598 2019
5
Effect Sizes in Single-Case Aphasia Studies: A Comparative, Autocorrelation-Oriented Analysis. 38
31260377 2019
6
Enhancing the Efficiency of Confrontation Naming Assessment for Aphasia Using Computer Adaptive Testing. 38
31158037 2019
7
Correlates of anomia in non-semantic variants of primary progressive aphasia converge over time. 38
31325799 2019
8
Four cases of natalizumab-related PML: a less severe course in extended interval dosing? 38
31175467 2019
9
A machine-learned analysis suggests non-redundant diagnostic information in olfactory subtests. 38
30671562 2019
10
Self-reported inner speech relates to phonological retrieval ability in people with aphasia. 38
30921682 2019
11
'What's cooking?' A comparison of an activity-oriented and a table-top programme of therapy on the language performance of people with aphasia. 38
30548111 2019
12
Morphometric correlates of anomia in patients with small left temporopolar lesions. 38
31059211 2019
13
Selection for sentence generation in the context of severe anomia: A case series of left temporal patients. 38
30608030 2019
14
Code-switching in multilinguals with dementia: patterns across speech contexts. 38
31017031 2019
15
Case of right hemispatial neglect and transcortical sensory aphasia following left occipitotemporoparietal glioblastoma resection. 38
30987454 2019
16
Storage, Degradation, and New Connectivity of Face-Related Semantic Memory in Alzheimer's Disease. 38
31007428 2019
17
Clinical and neuroimaging investigations of language disturbance in frontotemporal dementia-motor neuron disease patients. 38
30707358 2019
18
Analysis of naming processing stages in patients with mild Alzheimer. 38
31030561 2019
19
Validity and features of spontaneous speech in acute aphasia as evaluated with the Brief Aphasia Evaluation: is fluent aphasia more severe than nonfluent aphasia? 38
30843923 2019
20
Efficacy of a self-administered treatment using a smart tablet to improve functional vocabulary in post-stroke aphasia: a case-series study. 38
30426650 2019
21
Modified semantic feature analysis for anomia: a single case study. 38
30907157 2019
22
Language Mapping of Hindi and English in A Bilingual Patient During Resection of A Right Frontal Glioma - A Case Report. 38
30735861 2019
23
Anomia for musical entities. 38
31031508 2019
24
Effects of Phonomotor Treatment on discourse production. 38
30956383 2019
25
Evaluating Personal Stroke Narratives from Bilingual Greek-English Immigrants with Aphasia. 38
31085928 2019
26
[On the Issue of Evolution of the Concept of "Public Health"]. 38
30790482 2019
27
Evidence for a functional specialization of ventral anterior temporal lobe for language. 38
30165255 2018
28
Cognitive consequences of the left-right asymmetry of atrophy in semantic dementia. 38
29289335 2018
29
[FROM THEORY TO THE CLINIC - IS IT POSSIBLE TO DETECT DIFFERENT TYPES OF ANOMIA ACCORDING TO THE LEXICAL RETRIEVAL MODEL?] 38
30221856 2018
30
Treatment for spoken and written word retrieval in the semantic variant of primary progressive aphasia. 38
30198389 2018
31
[18F]THK-5351 PET imaging in early-stage semantic variant primary progressive aphasia: a report of two cases and a literature review. 38
30089453 2018
32
Treatment for Lexical Retrieval Impairments in Primary Progressive Aphasia: A Research Update with Implications for Clinical Practice. 38
29933491 2018
33
Typicality-based semantic treatment for anomia results in multiple levels of generalisation. 38
30027828 2018
34
A lexical semantic hub for heteromodal naming in middle fusiform gyrus. 38
29860298 2018
35
Functional compensation of the left inferior longitudinal fasciculus for picture naming. 38
29879863 2018
36
The eyes reveal uncertainty about object distinctions in semantic variant primary progressive aphasia. 38
29753915 2018
37
Frontotemporal stimulation modulates semantically-guided visual search during confrontation naming: A combined tDCS and eye tracking investigation. 38
29655024 2018
38
Parietal association deficits in patients harboring parietal lobe gliomas: a prospective study. 38
29726775 2018
39
Method for temporal keyhole lobectomies in resection of low- and high-grade gliomas. 38
28686118 2018
40
Prophylaxis and remediation of anomia in the semantic and logopenic variants of primary progressive aphasia. 38
26892944 2018
41
The error of Broca: From the traditional localizationist concept to a connectomal anatomy of human brain. 38
28416459 2018
42
Response Time Inconsistencies in Object and Action Naming in Anomic Aphasia. 38
29497757 2018
43
Links Between Short-Term Memory and Word Retrieval in Aphasia. 38
29497750 2018
44
Masked Repetition Priming Treatment for Anomia. 38
29486491 2018
45
Practice effects in healthy older adults: Implications for treatment-induced neuroplasticity in Aphasia. 38
29246487 2018
46
The different patterns of seizure-induced aphasia in temporal lobe epilepsies. 38
29128469 2018
47
Therapy-Induced Neuroplasticity in Chronic Aphasia After Phonological Component Analysis: A Matter of Intensity. 38
29686646 2018
48
A case series comparison of semantically focused vs. phonologically focused cued naming treatment in aphasia. 38
28590140 2018
49
Long-Term maintenance of anomia treatment effects in primary progressive aphasia. 38
29380657 2018
50
The Progressive Acalculia Presentation of Parietal Variant Alzheimer's Disease. 38
29710718 2018

Variations for Nominal Aphasia

Expression for Nominal Aphasia

Search GEO for disease gene expression data for Nominal Aphasia.

Pathways for Nominal Aphasia

Pathways related to Nominal Aphasia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.29 MAPT DES CHMP2B

GO Terms for Nominal Aphasia

Molecular functions related to Nominal Aphasia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 double-stranded DNA binding GO:0003690 8.96 TARDBP MAPT
2 identical protein binding GO:0042802 8.92 TARDBP MAPT GRASP DES

Sources for Nominal Aphasia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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