Aliases & Classifications for Nominal Aphasia

MalaCards integrated aliases for Nominal Aphasia:

Name: Nominal Aphasia 12 15
Anomia 12 43 71
Anomic Aphasia 12 74

Classifications:



External Ids:

Disease Ontology 12 DOID:4541
MeSH 43 D000849
NCIt 49 C34386
SNOMED-CT 67 10325006
UMLS 71 C0003113

Summaries for Nominal Aphasia

Disease Ontology : 12 An agnosia that involves a severe problem with recalling words or names.

MalaCards based summary : Nominal Aphasia, also known as anomia, is related to frontotemporal lobar degeneration with tdp43 inclusions, grn-related and semantic dementia, and has symptoms including scanning speech and other symbolic dysfunction. An important gene associated with Nominal Aphasia is GRN (Granulin Precursor). The drugs Acetylcholine and tannic acid have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and temporal lobe, and related phenotypes are hematopoietic system and integument

Wikipedia : 74 Anomic aphasia (also known as dysnomia, nominal aphasia, and amnesic aphasia) is a mild, fluent type of... more...

Related Diseases for Nominal Aphasia

Diseases related to Nominal Aphasia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 124)
# Related Disease Score Top Affiliating Genes
1 frontotemporal lobar degeneration with tdp43 inclusions, grn-related 31.5 MAPT GRN
2 semantic dementia 31.3 TARDBP MAPT GRN CHMP2B C9orf72 APOE
3 dysgraphia 30.2 TARDBP MAPT GRN CHMP2B CBSL C9orf72
4 ideomotor apraxia 29.9 TARDBP MAPT GRN CBSL ADAMTS2
5 apraxia 29.8 MAPT GRN C9orf72 APOE
6 amnestic disorder 29.7 MAPT APOE ACHE
7 vascular dementia 29.5 MAPT APOE ACHE
8 alexia 29.3 PRSS3 MTSS2 MAPT GRN CBSL APOE
9 binswanger's disease 29.3 MAPT APOE ACHE
10 associative agnosia 29.0 VCP TARDBP MAPT GRN FUS CHMP2B
11 agraphia 28.6 VCP TARDBP PRSS3 MTSS2 MAPT GRN
12 pick disease of brain 28.4 VCP TARDBP MAPT GRN FUS CHMP2B
13 visual agnosia 28.1 PCAT2 MTSS2 MAPT GRN CBSL APOE
14 frontotemporal dementia 27.7 VCP TARDBP MAPT GRN FUS CHMP2B
15 aphasia 27.6 VCP TARDBP PRSS3 MAPT GRN FUS
16 dementia 27.5 VCP TARDBP MAPT GRN FUS CHMP2B
17 speech and communication disorders 25.9 VCP TARDBP PRSS3 MAPT GRN GNAS-AS1
18 alzheimer disease 10.4
19 amyotrophic lateral sclerosis type 22 10.4 TARDBP C9orf72
20 gait apraxia 10.4 GRN CBSL
21 frontotemporal dementia and/or amyotrophic lateral sclerosis 3 10.3 TARDBP C9orf72
22 akinetic mutism 10.3 TARDBP MAPT
23 amyotrophic lateral sclerosis type 15 10.3 CHMP2B C9orf72
24 postencephalitic parkinson disease 10.3 TARDBP MAPT
25 corticobasal degeneration 10.3 TARDBP MAPT
26 amyotrophic lateral sclerosis-parkinsonism/dementia complex 1 10.2 TARDBP MAPT C9orf72
27 pseudobulbar palsy 10.2 TARDBP C9orf72
28 paraphilia disorder 10.2 GRN ADAMTS2
29 arteriovenous malformation 10.2
30 echolalia 10.2 MAPT GRN
31 amusia 10.2 GRN GNAS-AS1
32 agnosia 10.1
33 herpes simplex 10.1
34 herpes simplex encephalitis 10.1
35 progressive bulbar palsy 10.1 FUS C9orf72
36 muscular atrophy 10.1 TARDBP FUS C9orf72
37 autotopagnosia 10.1
38 chronic meningitis 10.1
39 meningoencephalitis 10.1
40 neurosarcoidosis 10.1
41 amyotrophic lateral sclerosis 18 10.1 FUS CHMP2B
42 amyotrophic lateral sclerosis 4, juvenile 10.1 TARDBP FUS C9orf72
43 dermatopathia pigmentosa reticularis 10.1 TARDBP FUS C9orf72
44 spinal and bulbar muscular atrophy, x-linked 1 10.1 TARDBP FUS C9orf72
45 spinocerebellar ataxia 2 10.1 TARDBP FUS C9orf72
46 amyotrophic lateral sclerosis 12 10.1 TARDBP FUS CHMP2B
47 amyotrophic lateral sclerosis 11 10.1 TARDBP FUS CHMP2B
48 mutism 10.0 MAPT GRN CHMP2B C9orf72
49 essential tremor 10.0 MAPT FUS C9orf72
50 papillomatosis, confluent and reticulated 10.0

Graphical network of the top 20 diseases related to Nominal Aphasia:



Diseases related to Nominal Aphasia

Symptoms & Phenotypes for Nominal Aphasia

UMLS symptoms related to Nominal Aphasia:


scanning speech, other symbolic dysfunction

MGI Mouse Phenotypes related to Nominal Aphasia:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.97 ACHE APOE C9orf72 CBSL GRN MAPT
2 integument MP:0010771 9.8 ADAMTS2 APOE C9orf72 CBSL GRN MAPT
3 muscle MP:0005369 9.63 ACHE APOE CBSL MAPT TARDBP VCP
4 nervous system MP:0003631 9.61 ACHE APOE C9orf72 CBSL CHMP2B GRN
5 no phenotypic analysis MP:0003012 9.1 ACHE APOE C9orf72 GRN MAPT TARDBP

Drugs & Therapeutics for Nominal Aphasia

Drugs for Nominal Aphasia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 26)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved, Investigational Phase 4 51-84-3 187
2
tannic acid Approved Phase 4 1401-55-4
3
Topiramate Approved Phase 4 97240-79-4 5284627
4
Benzocaine Approved, Investigational Phase 4 94-09-7, 1994-09-7 2337
5 abobotulinumtoxinA Phase 4
6 Botulinum Toxins, Type A Phase 4
7 Hypoglycemic Agents Phase 4
8 Anticonvulsants Phase 4
9 Botulinum Toxins Phase 4
10
Donepezil Approved Phase 3 120014-06-4 3152
11 Neurotransmitter Agents Phase 3
12 Cholinergic Agents Phase 3
13 Cholinesterase Inhibitors Phase 3
14
Corticosterone Experimental Phase 1 50-22-6 5753
15 Fluorodeoxyglucose F18 Phase 1
16 Deoxyglucose Phase 1
17 Radiopharmaceuticals Phase 1
18
Levodopa Approved 59-92-7 6047
19
Benserazide Approved, Investigational 322-35-0
20
Dopamine Approved 51-61-6, 62-31-7 681
21
Cefpodoxime Approved, Vet_approved 80210-62-4, 82619-04-3 6335986
22 Dopamine agonists
23 Antiparkinson Agents
24 Dopamine Agents
25 Cefpodoxime proxetil
26 Anesthetics

Interventional clinical trials:

(show all 34)
# Name Status NCT ID Phase Drugs
1 A Randomized, Pilot Study to Evaluate the Tolerability of OnabotulinumtoxinA Plus Topiramate vs. OnabotulinumtoxinA Plus Placebo and Long Term Effect of Treatment on Cognitive Efficiency and Continuation of Care Completed NCT01700387 Phase 4 onabotulinumtoxinA;Topiramate;Placebo
2 Effects of Combining Donepezil, Intensive Language Rehabilitation and Transcranial Direct Current Stimulation on Language Recovery and Brain Reorganization in Chronic Post-stroke Aphasia Recruiting NCT04134416 Phase 3 Donepezil
3 Chronic Aphasia - Improved by Intensive Training and Electrical Brain Unknown status NCT01221779 Phase 2
4 Chronic Aphasia - Improved by Intensive Training and Electrical Brain Stimulation (CATS) Unknown status NCT01924702 Phase 2
5 Targeted Transcranial Electrotherapy for Stroke Rehabilitation - Exploratory Trial on Aphasia Recruiting NCT02540109 Phase 2
6 High Definition-transcranial Direct Current Stimulation (HD-tDCS) for Stroke Rehabilitation Completed NCT01651884 Phase 1
7 Treatment of Language and Memory in Patients With Alzheimer's Disease: A Comparison Between Drug Therapy and Drug Therapy Plus Behavioral Intervention Completed NCT00593372 Phase 1
8 PiB PET Scanning in Speech and Language Based Dementias Completed NCT01623284 Phase 1 C-11 PiB;F-18 FDG
9 Overcoming Learned Non-Use in Chronic Aphasia: Behavioral, fMRI and QoL Outcomes Unknown status NCT02012374
10 A Prospective, Controlled Study of Rehabilitation of Anomia in Aphasia Completed NCT02153710
11 Effect of Dopaminergic Medication on Recovery of Aphasia Completed NCT00941265 levodopa and benserazide;placebo
12 Learning Paradigms in Aphasia Rehabilitation Completed NCT00494520
13 The Center for the Neurobiology of Language Recovery (CNLR) Completed NCT01927302
14 Brain Connectivity Supporting Language Recovery in Aphasia Completed NCT02416856
15 Slowing Language Decline in Progressive Aphasia Through Language Rehabilitation: Treatment and Neuroimaging Study Completed NCT00957710
16 Communication Outcomes for Naming Treatments in Aphasia Completed NCT00764400
17 Improving Word Repetition Training Using Classical Conditioning With a Computer Based Telemedicine Approach: Evidence From a Study on 12 Person With Chronic Aphasia. Completed NCT03381313
18 Language Assessment and Treatment Following Acquired Brain Injury Completed NCT03320954
19 Role of the Right Brain in Recovery of Language Function in Chronic Stroke Completed NCT00076479
20 Preventing Language Decline in Dementia Completed NCT02541097
21 Does Inner Speech Improve Access to Overt Speech in Aphasia Following Stroke? An fMRI Study Utilising Computerised Rehabilitation Software. Completed NCT01928602
22 Effects of a Combination of Transcranial Direct Stimulation (tDCS) and Behavioral Intervention in Non-fluent Aphasia Completed NCT02226796
23 Finding the Right Words in Neurogenic Communication Disorders: Naming of Objects and Actions, Communicative Strategies in Conversation and Effects of Training Recruiting NCT03568760
24 Mechanisms Underlying Spoken Language Production: Facilitating Frontal Brain Networks Following Aphasic Stroke Recruiting NCT04138433
25 Treatment Outcomes and Brain Mechanisms Associated With Non-Invasive Neuromodulation in Post-Stroke Aphasia Recruiting NCT03929432
26 Rehabilitation and Prophylaxis of Anomia in Primary Progressive Aphasia Recruiting NCT02675270
27 Rehabilitating and Decelerating Language Loss in Primary Progressive Aphasia With Transcranial Direct Current Stimulation (tDCS) Plus Language Therapy Recruiting NCT03728582
28 Application of Graph Theory to Both Resting-state and Task-based fMRI Data to Uncover Brain-behavior Relationships Related to Therapy Outcomes in Aphasia Recruiting NCT03550092
29 (C-STAR) Center for the Study of Aphasia Recovery Modeling Treated Recovery From Aphasia Recruiting NCT03416738
30 Optimizing and Understanding Semantic Feature Analysis Treatment for Aphasia: A Randomized Controlled Comparative Effectiveness Trial Recruiting NCT04215952
31 Intention Treatment for Anomia: Investigating Dose Frequency Effects and Predictors of Treatment Response to Improve Efficacy and Clinical Translation Not yet recruiting NCT04267198
32 Prospective Study of Awake Intraoperative Language Mapping and Construction of Chinese Probabilistic Map Based on Direct Electrical Stimulation Not yet recruiting NCT03641391
33 Voice Adaptive Training for Adults With Aphasia Not yet recruiting NCT04108364
34 Pairing Word Retrieval and Physical Endurance Tasks to Treat Anomia Withdrawn NCT03326687

Search NIH Clinical Center for Nominal Aphasia

Cochrane evidence based reviews: anomia

Genetic Tests for Nominal Aphasia

Anatomical Context for Nominal Aphasia

MalaCards organs/tissues related to Nominal Aphasia:

40
Brain, Testes, Temporal Lobe, Eye, Cortex, Parietal Lobe, Thalamus

Publications for Nominal Aphasia

Articles related to Nominal Aphasia:

(show top 50) (show all 701)
# Title Authors PMID Year
1
Clinical Features of Late-onset Semantic Dementia. 61
32496297 2020
2
Treatment for spoken and written word retrieval in the semantic variant of primary progressive aphasia. 61
30198389 2020
3
Multimodal semantic battery to monitor progressive loss of concepts in the semantic variant of primary progressive aphasia (svPPA): an innovative proposal. 61
32573335 2020
4
[Evaluation of Semantic Dementia Patient]. 61
32507758 2020
5
Typicality-based semantic treatment for anomia results in multiple levels of generalisation. 61
30027828 2020
6
Morphometric correlates of anomia in patients with small left temporopolar lesions. 61
31059211 2020
7
[Financial fraud and health: a qualitative approach]. 61
31964535 2020
8
COVID-19 Anosmia Reporting Tool: Initial Findings. 61
32340555 2020
9
Apraxia of speech involves lesions of dorsal arcuate fasciculus and insula in patients with aphasia. 61
32309035 2020
10
A Retrospective Study of Long-Term Improvement on the Boston Naming Test. 61
31419151 2020
11
Empirical Evaluation of Computer-Adaptive Alternate Short Forms for the Assessment of Anomia Severity. 61
31851861 2020
12
A description of verbal and gestural communication during postictal aphasia. 61
31759317 2020
13
Report of a Case of Creutzfeldt-Jakob Disease With an Unusual Clinical Presentation. 61
32327983 2020
14
Phonomotor Versus Semantic Feature Analysis Treatment for Anomia in 58 Persons With Aphasia: A Randomized Controlled Trial. 61
31805247 2019
15
TDQ-30-A New Color Picture-Naming Test for the Diagnostic of Mild Anomia: Validation and Normative Data in Quebec French Adults and Elderly. 61
31792492 2019
16
The Influence of Phonomotor Treatment on Word Retrieval: Insights From Naming Errors. 61
31682780 2019
17
Evidence for indirect loss of significance effects on violent extremism: The potential mediating role of anomia. 61
31452219 2019
18
Correlates of anomia in non-semantic variants of primary progressive aphasia converge over time. 61
31325799 2019
19
Long-Term maintenance of anomia treatment effects in primary progressive aphasia. 61
29380657 2019
20
Remembering a name: Neuropsychological validity studies and a computer proposal for detection of anomia. 61
31844500 2019
21
Four cases of natalizumab-related PML: a less severe course in extended interval dosing? 61
31175467 2019
22
Expected performance of Quebec-French older adults on the Batterie Rapide de Dénomination (BARD). 61
31544520 2019
23
Naming difficulties after thyroid stimulating hormone suppression therapy in patients with differentiated thyroid carcinoma: a prospective cohort study. 61
31056722 2019
24
The Link Between Verbal Short-Term Memory and Anomia Treatment Gains. 61
31112652 2019
25
Comparing the effects of clinician and caregiver-administered lexical retrieval training for progressive anomia. 61
28662598 2019
26
Effect Sizes in Single-Case Aphasia Studies: A Comparative, Autocorrelation-Oriented Analysis. 61
31260377 2019
27
Enhancing the Efficiency of Confrontation Naming Assessment for Aphasia Using Computer Adaptive Testing. 61
31158037 2019
28
A machine-learned analysis suggests non-redundant diagnostic information in olfactory subtests. 61
30671562 2019
29
Self-reported inner speech relates to phonological retrieval ability in people with aphasia. 61
30921682 2019
30
'What's cooking?' A comparison of an activity-oriented and a table-top programme of therapy on the language performance of people with aphasia. 61
30548111 2019
31
Functional compensation of the left inferior longitudinal fasciculus for picture naming. 61
29879863 2019
32
Language Mapping of Hindi and English in a Bilingual Patient During Resection of a Right Frontal Glioma. 61
30735861 2019
33
Selection for sentence generation in the context of severe anomia: A case series of left temporal patients. 61
30608030 2019
34
Case of right hemispatial neglect and transcortical sensory aphasia following left occipitotemporoparietal glioblastoma resection. 61
30987454 2019
35
Storage, Degradation, and New Connectivity of Face-Related Semantic Memory in Alzheimer's Disease. 61
31007428 2019
36
Clinical and neuroimaging investigations of language disturbance in frontotemporal dementia-motor neuron disease patients. 61
30707358 2019
37
Analysis of naming processing stages in patients with mild Alzheimer. 61
31030561 2019
38
Efficacy of a self-administered treatment using a smart tablet to improve functional vocabulary in post-stroke aphasia: a case-series study. 61
30426650 2019
39
Validity and features of spontaneous speech in acute aphasia as evaluated with the Brief Aphasia Evaluation: is fluent aphasia more severe than nonfluent aphasia? 61
30843923 2019
40
Evaluating Personal Stroke Narratives from Bilingual Greek-English Immigrants with Aphasia. 61
31085928 2019
41
Maximizing the Treatment Benefit of tDCS in Neurodegenerative Anomia. 61
31824242 2019
42
Naming and Knowing Revisited: Eyetracking Correlates of Anomia in Progressive Aphasia. 61
31680908 2019
43
Modified semantic feature analysis for anomia: a single case study. 61
30907157 2019
44
Code-switching in multilinguals with dementia: patterns across speech contexts. 61
31017031 2019
45
Anomia for musical entities. 61
31031508 2019
46
Effects of Phonomotor Treatment on discourse production. 61
30956383 2019
47
[On the Issue of Evolution of the Concept of "Public Health"]. 61
30790482 2019
48
Evidence for a functional specialization of ventral anterior temporal lobe for language. 61
30165255 2018
49
Cognitive consequences of the left-right asymmetry of atrophy in semantic dementia. 61
29289335 2018
50
[FROM THEORY TO THE CLINIC - IS IT POSSIBLE TO DETECT DIFFERENT TYPES OF ANOMIA ACCORDING TO THE LEXICAL RETRIEVAL MODEL?] 61
30221856 2018

Variations for Nominal Aphasia

Expression for Nominal Aphasia

Search GEO for disease gene expression data for Nominal Aphasia.

Pathways for Nominal Aphasia

GO Terms for Nominal Aphasia

Cellular components related to Nominal Aphasia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.76 VCP PRSS3 MAPT GRN C9orf72 APOE
2 dendrite GO:0030425 9.62 MAPT FUS C9orf72 APOE
3 synaptic cleft GO:0043083 9.26 APOE ACHE
4 cytoplasmic stress granule GO:0010494 9.13 VCP TARDBP C9orf72
5 main axon GO:0044304 8.62 MAPT C9orf72

Biological processes related to Nominal Aphasia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 autophagy GO:0006914 9.5 VCP CHMP2B C9orf72
2 regulation of synapse organization GO:0050807 9.26 VCP APOE
3 stress granule assembly GO:0034063 9.16 MAPT C9orf72
4 amyloid precursor protein metabolic process GO:0042982 8.96 APOE ACHE
5 gene expression GO:0010467 8.8 TARDBP FUS APOE

Molecular functions related to Nominal Aphasia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.43 VCP TARDBP MAPT FUS APOE ACHE
2 lipoprotein particle binding GO:0071813 8.62 MAPT APOE

Sources for Nominal Aphasia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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