Aliases & Classifications for Nominal Aphasia

MalaCards integrated aliases for Nominal Aphasia:

Name: Nominal Aphasia 12 15
Anomia 12 44 73
Anomic Aphasia 12 76

Classifications:



External Ids:

Disease Ontology 12 DOID:4541
MeSH 44 D000849
NCIt 50 C34386
SNOMED-CT 68 10325006
UMLS 73 C0003113

Summaries for Nominal Aphasia

Disease Ontology : 12 An agnosia that involves a severe problem with recalling words or names.

MalaCards based summary : Nominal Aphasia, also known as anomia, is related to semantic dementia and pick disease of brain, and has symptoms including scanning speech and other symbolic dysfunction. An important gene associated with Nominal Aphasia is PSEN1 (Presenilin 1), and among its related pathways/superpathways are Neuroscience and Alzheimers Disease Pathway. The drugs Cefpodoxime and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include brain and temporal lobe, and related phenotype is nervous system.

Wikipedia : 76 Anomic aphasia (also known as dysnomia, nominal aphasia, and amnesic aphasia) is a mild, fluent type of... more...

Related Diseases for Nominal Aphasia

Diseases related to Nominal Aphasia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Related Disease Score Top Affiliating Genes
1 semantic dementia 31.2 CHMP2B GRN MAPT PSEN1 TARDBP
2 pick disease of brain 30.9 GRN MAPT PSEN1 TARDBP
3 frontotemporal lobar degeneration with tdp43 inclusions, grn-related 30.4 GRN MAPT
4 alexia 30.3 PSEN1 TARDBP
5 aphasia 30.1 CHMP2B GRN MAPT PSEN1
6 alzheimer disease 29.7 GRN MAPT PSEN1 TARDBP
7 agraphia 29.6 GRN MAPT PSEN1 TARDBP
8 dementia 29.2 CHMP2B GRN MAPT PSEN1 TARDBP
9 autotopagnosia 10.1
10 dysgraphia 10.1
11 prosopagnosia 10.1 GRN PSEN1
12 gait apraxia 10.0 GRN PSEN1
13 mutism 10.0 CHMP2B GRN
14 expressive language disorder 10.0 PSEN1 TARDBP
15 visual agnosia 10.0 GRN PSEN1
16 schizophrenia 9.9
17 dyslexia 9.9
18 herpes simplex 9.9
19 intracranial hypertension 9.9
20 encephalitis 9.9
21 herpes simplex encephalitis 9.9
22 depression 9.9
23 familial idiopathic basal ganglia calcification 9.9 MAPT PSEN1
24 ideomotor apraxia 9.9 GRN MAPT
25 perry syndrome 9.9 GRN TARDBP
26 kohlschutter-tonz syndrome 9.9 MAPT PSEN1
27 kluver-bucy syndrome 9.9 MAPT PSEN1
28 alzheimer disease 2 9.9 MAPT PSEN1
29 specific developmental disorder 9.9 GRN PSEN1
30 cerebral amyloid angiopathy, cst3-related 9.9 MAPT PSEN1
31 postencephalitic parkinson disease 9.9 MAPT TARDBP
32 phonagnosia 9.8 GRN PSEN1 TARDBP
33 associative agnosia 9.8 GRN PSEN1 TARDBP
34 writing disorder 9.8 GRN PSEN1 TARDBP
35 spinocerebellar ataxia 11 9.8 MAPT TARDBP
36 corticobasal degeneration 9.8 MAPT TARDBP
37 vascular dementia 9.8 MAPT PSEN1
38 inclusion body myositis 9.8 MAPT TARDBP
39 echolalia 9.8 GRN MAPT PSEN1
40 apraxia 9.8 GRN MAPT PSEN1
41 nervous system disease 9.7 MAPT PSEN1 TARDBP
42 central nervous system disease 9.7 MAPT PSEN1 TARDBP
43 motor neuron disease 9.7 GRN MAPT TARDBP
44 synucleinopathy 9.7 CHMP2B MAPT
45 progressive non-fluent aphasia 9.6 CHMP2B GRN MAPT PSEN1
46 behavioral variant of frontotemporal dementia 9.6 CHMP2B GRN MAPT PSEN1
47 supranuclear palsy, progressive, 1 9.5 GRN MAPT PSEN1 TARDBP
48 dementia, lewy body 9.5 GRN MAPT PSEN1 TARDBP
49 speech and communication disorders 9.5 GRN MAPT PSEN1 TARDBP
50 disease of mental health 9.5 GRN MAPT PSEN1 TARDBP

Graphical network of the top 20 diseases related to Nominal Aphasia:



Diseases related to Nominal Aphasia

Symptoms & Phenotypes for Nominal Aphasia

UMLS symptoms related to Nominal Aphasia:


scanning speech, other symbolic dysfunction

MGI Mouse Phenotypes related to Nominal Aphasia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.02 CHMP2B GRN MAPT PSEN1 TARDBP

Drugs & Therapeutics for Nominal Aphasia

Drugs for Nominal Aphasia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cefpodoxime Approved, Vet_approved Not Applicable 82619-04-3, 80210-62-4 6335986
2
Dopamine Approved Not Applicable 51-61-6, 62-31-7 681
3
Levodopa Approved Not Applicable 59-92-7 6047
4
Benserazide Approved, Investigational Not Applicable 322-35-0
5 Cefpodoxime proxetil Not Applicable
6 Peripheral Nervous System Agents Not Applicable
7 Neurotransmitter Agents Not Applicable
8 Dopamine Agents Not Applicable
9 Sympathomimetics Not Applicable
10 Antiparkinson Agents Not Applicable
11 Dopamine agonists Not Applicable
12 Autonomic Agents Not Applicable
13 Cardiotonic Agents Not Applicable
14 Protective Agents Not Applicable

Interventional clinical trials:

(show all 22)
# Name Status NCT ID Phase Drugs
1 Targeted Electrotherapy for Aphasia Stroke Rehabilitation (TEASER) - Phase II Multi-Center Study Unknown status NCT02540109 Phase 2
2 Chronic Aphasia - Improved by Intensive Training and Electrical Brain Stimulation Unknown status NCT01221779 Phase 2
3 Chronic Aphasia - Improved by Intensive Training and Electrical Brain Stimulation (CATS) Unknown status NCT01924702 Phase 2
4 Effect of Verb Network Strengthening Treatment (VNeST) on Lexical Retrieval in Aphasia Completed NCT01300624 Phase 2
5 Effects of tDCS Versus HD-tDCS for Stroke Rehabilitation Completed NCT01651884 Phase 1
6 Exercise as an Adjuvant to Aphasia Therapy Completed NCT01113879 Phase 1
7 Overcoming Learned Non-Use in Chronic Aphasia Unknown status NCT02012374 Not Applicable
8 Speech Therapy for Aphasia: Comparing Two Treatments Completed NCT02153710 Not Applicable
9 Language Treatment for Progressive Aphasia Completed NCT00957710 Not Applicable
10 Cognitive Therapy to Improve Word Finding Completed NCT00494520 Not Applicable
11 Effect of Dopaminergic Medication on Recovery of Aphasia Completed NCT00941265 Not Applicable levodopa and benserazide;placebo
12 Classical Conditioning Training for Aphasia. A Telemedicine Approach. Completed NCT03381313 Not Applicable
13 Brain Connectivity Supporting Language Recovery in Aphasia Completed NCT02416856
14 Treatment for Word Retrieval Impairments in Aphasia Completed NCT00764400 Not Applicable
15 Language Assessment and Treatment Following Acquired Brain Injury Recruiting NCT03320954 Not Applicable
16 Finding the Right Words in Neurogenic Communication Disorders Recruiting NCT03568760 Not Applicable
17 Rehabilitation and Prophylaxis of Anomia in Primary Progressive Aphasia Recruiting NCT02675270 Not Applicable
18 Rehabilitating and Decelerating Language Loss in Primary Progressive Aphasia With tDCS Plus Language Therapy Recruiting NCT03728582 Not Applicable
19 Analysis of Brain Activity to Uncover Brain-behavior Relationships Related to Therapy Outcomes in Aphasia Recruiting NCT03550092 Not Applicable
20 Modeling Treated Recovery From Aphasia Recruiting NCT03416738 Not Applicable
21 Neurobiology of Language Recovery in Aphasia: Natural History and Treatment-Induced Recovery Active, not recruiting NCT01927302 Not Applicable
22 Pairing Word Retrieval and Physical Endurance Tasks to Treat Anomia in People With Aphasia Withdrawn NCT03326687 Not Applicable

Search NIH Clinical Center for Nominal Aphasia

Cochrane evidence based reviews: anomia

Genetic Tests for Nominal Aphasia

Anatomical Context for Nominal Aphasia

MalaCards organs/tissues related to Nominal Aphasia:

41
Brain, Temporal Lobe

Publications for Nominal Aphasia

Articles related to Nominal Aphasia:

(show top 50) (show all 164)
# Title Authors Year
1
Prophylaxis and remediation of anomia in the semantic and logopenic variants of primary progressive aphasia. ( 26892944 )
2018
2
Masked Repetition Priming Treatment for Anomia. ( 29486491 )
2018
3
Typicality-based semantic treatment for anomia results in multiple levels of generalisation. ( 30027828 )
2018
4
The Neural and Behavioral Correlates of Anomia Recovery following Personalized Observation, Execution, and Mental Imagery Therapy: A Proof of Concept. ( 30154837 )
2018
5
Influence of Cognitive Ability on Therapy Outcomes for Anomia in Adults With Chronic Poststroke Aphasia. ( 28199471 )
2017
6
Exploring classical conditioning for strengthening the links between semantic and lexical representations in pure anomia: Preliminary findings from a single case study. ( 26526282 )
2017
7
Stereotactic probability and variability of speech arrest and anomia sites during stimulation mapping of the language dominant hemisphere. ( 26894457 )
2017
8
Common and divergent neural correlates of anomia in amnestic and logopenic presentations of Alzheimer's disease. ( 27875715 )
2017
9
Effectiveness of technologies in the treatment of post-stroke anomia: A systematic review. ( 28171741 )
2017
10
Semantic Feature Training in Combination with Transcranial Direct Current Stimulation (tDCS) for Progressive Anomia. ( 28559805 )
2017
11
Comparing the effects of clinician and caregiver-administered lexical retrieval training for progressive anomia. ( 28662598 )
2017
12
Less is more: neural mechanisms underlying anomia treatment in chronic aphasic patients. ( 29053773 )
2017
13
Reduced neural 'effort' after naming treatment in anomia. ( 29088349 )
2017
14
Semantic Feature Training for the Treatment of Anomia in Alzheimer Disease: A Preliminary Investigation. ( 27008248 )
2016
15
Taking Sides: An Integrative Review of the Impact of Laterality and Polarity on Efficacy of Therapeutic Transcranial Direct Current Stimulation for Anomia in Chronic Poststroke Aphasia. ( 26819777 )
2016
16
Telerehabilitation of Anomia in Primary Progressive Aphasia. ( 27087732 )
2016
17
Success of Anomia Treatment in Aphasia Is Associated With Preserved Architecture of Global and Left Temporal Lobe Structural Networks. ( 26150147 )
2016
18
The relationship between novel word learning and anomia treatment success in adults with chronic aphasia. ( 26724545 )
2016
19
Treatment of verb anomia in aphasia: efficacy of self-administered therapy using a smart tablet. ( 26007615 )
2016
20
Long-term proper name anomia after removal of the uncinate fasciculus. ( 25348267 )
2016
21
The neural correlates of anomia in the conversion from mild cognitive impairment to Alzheimer's disease. ( 26400852 )
2016
22
Prophylactic Treatments for Anomia in the Logopenic Variant of Primary Progressive Aphasia: Cross-Language Transfer. ( 26257456 )
2015
23
Improving verb anomia in the semantic variant of primary progressive aphasia: the effectiveness of a semantic-phonological cueing treatment. ( 24827737 )
2015
24
Proper name anomia after right-hemispheric lesion: a case study. ( 25105322 )
2015
25
An exploration of anomia as origin of work absence. ( 25248533 )
2015
26
Proper name anomia in poststroke aphasics: evidence from a multiple-case study. ( 25274199 )
2015
27
Proper name anomia with preserved lexical and semantic knowledge after left anterior temporal lesion: a two-way convergence defect. ( 25617826 )
2015
28
Anomia produced by direct cortical stimulation of the pre-supplementary motor area in a patient undergoing preoperative language mapping. ( 26030473 )
2015
29
Masked Repetition Priming in Treatment of Anomia: A Phase 2 Study. ( 26381369 )
2015
30
Nonverbal Working Memory as a Predictor of Anomia Treatment Success. ( 26383918 )
2015
31
Delayed Stimulus-Specific Improvements in Discourse Following Anomia Treatment Using an Intentional Gesture. ( 24129014 )
2014
32
Changes in white matter connectivity following therapy for anomia post stroke. ( 24297762 )
2014
33
Neural activity associated with semantic versus phonological anomia treatments in aphasia. ( 24556337 )
2014
34
Dosing of a cued picture-naming treatment for anomia. ( 24686830 )
2014
35
Syntactic versus lexical therapy for anomia in acquired aphasia: differential effects on narrative and conversation. ( 24741697 )
2014
36
Telerehabilitation in poststroke anomia. ( 24829914 )
2014
37
Anomia treatment platform as behavioral engine for use in research on physiological adjuvants to neurorehabilitation. ( 25019662 )
2014
38
An SEM approach to continuous time modeling of panel data: relating authoritarianism and anomia. ( 22486576 )
2012
39
Crossover trial of subacute computerized aphasia therapy for anomia with the addition of either levodopa or placebo. ( 20834044 )
2011
40
A controlled study of changes in conversation following aphasia therapy for anomia. ( 21128833 )
2011
41
How intensive does anomia therapy for people with aphasia need to be? ( 21181603 )
2011
42
Short-term anomia training and electrical brain stimulation. ( 21636820 )
2011
43
Extending the use of Spanish Computer-assisted Anomia Rehabilitation Program (CARP-2) in people with aphasia. ( 21794873 )
2011
44
The treatment of anomia in Sesotho: a case for parametric aphasiology. ( 22106896 )
2011
45
Simulated in-home teletreatment for anomia. ( 25945183 )
2011
46
Activity in preserved left hemisphere regions predicts anomia severity in aphasia. ( 19687294 )
2010
47
Generalization of the effects of phonological training for anomia using structural equation modelling: a multiple single-case study. ( 19967599 )
2010
48
Predicting the outcome of anomia therapy for people with aphasia post CVA: both language and cognitive status are key predictors. ( 20077315 )
2010
49
Anomia for people's names after left anterior temporal lobe resection--case report. ( 20098023 )
2010
50
Neural changes after phonological treatment for anomia: An fMRI study. ( 20547416 )
2010

Variations for Nominal Aphasia

Expression for Nominal Aphasia

Search GEO for disease gene expression data for Nominal Aphasia.

Pathways for Nominal Aphasia

Pathways related to Nominal Aphasia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.33 MAPT PSEN1 TARDBP
2 10.61 MAPT PSEN1

GO Terms for Nominal Aphasia

Cellular components related to Nominal Aphasia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth cone GO:0030426 8.62 MAPT PSEN1

Biological processes related to Nominal Aphasia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 autophagy GO:0006914 9.37 CHMP2B PSEN1
2 memory GO:0007613 9.32 MAPT PSEN1
3 negative regulation of protein phosphorylation GO:0001933 9.26 PSEN1 TARDBP
4 regulation of synaptic plasticity GO:0048167 9.16 MAPT PSEN1
5 synapse organization GO:0050808 8.96 MAPT PSEN1
6 astrocyte activation GO:0048143 8.62 MAPT PSEN1

Molecular functions related to Nominal Aphasia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 double-stranded DNA binding GO:0003690 8.62 MAPT TARDBP

Sources for Nominal Aphasia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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