Aliases & Classifications for Nominal Aphasia

MalaCards integrated aliases for Nominal Aphasia:

Name: Nominal Aphasia 12 15
Anomia 12 44 73
Anomic Aphasia 12 76

Classifications:



External Ids:

Disease Ontology 12 DOID:4541
MeSH 44 D000849
NCIt 50 C34386
SNOMED-CT 68 10325006
UMLS 73 C0003113

Summaries for Nominal Aphasia

Disease Ontology : 12 An agnosia that involves a severe problem with recalling words or names.

MalaCards based summary : Nominal Aphasia, also known as anomia, is related to semantic dementia and pick disease of brain, and has symptoms including scanning speech and other symbolic dysfunction. An important gene associated with Nominal Aphasia is PSEN1 (Presenilin 1). The drugs Benserazide and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include brain and temporal lobe, and related phenotypes are homeostasis/metabolism and hematopoietic system

Wikipedia : 76 Anomic aphasia (also known as dysnomia, nominal aphasia, and amnesic aphasia) is a mild, fluent type of... more...

Related Diseases for Nominal Aphasia

Diseases related to Nominal Aphasia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Related Disease Score Top Affiliating Genes
1 semantic dementia 31.7 C9orf72 CHMP2B GRN MAPT PSEN1 TARDBP
2 pick disease of brain 31.4 FUS GRN MAPT PSEN1 TARDBP
3 aphasia 30.6 C9orf72 CHMP2B GRN MAPT PSEN1
4 dementia 27.3 ACHE C9orf72 CHMP2B FUS GRN MAPT
5 frontotemporal lobar degeneration with tdp43 inclusions, grn-related 10.8 GRN MAPT
6 prosopagnosia 10.8 GRN PSEN1
7 alexia 10.8 PSEN1 TARDBP
8 phonagnosia 10.7 GRN PSEN1 TARDBP
9 associative agnosia 10.7 GRN PSEN1 TARDBP
10 writing disorder 10.7 GRN PSEN1 TARDBP
11 postpoliomyelitis syndrome 10.7 TARDBP VCP
12 mutism 10.7 CHMP2B GRN
13 familial idiopathic basal ganglia calcification 10.7 MAPT PSEN1
14 simultanagnosia 10.6 MAPT SMUG1
15 gait apraxia 10.6 CBS GRN PSEN1
16 inclusion body myopathy with paget disease of bone and frontotemporal dementia 10.6 TARDBP VCP
17 anosognosia 10.6 GRN SMUG1
18 postencephalitic parkinson disease 10.6 MAPT TARDBP
19 disease of mental health 10.6 GRN MAPT PSEN1
20 kluver-bucy syndrome 10.5 MAPT PSEN1
21 inclusion body myositis 10.5 MAPT TARDBP VCP
22 amyotrophic lateral sclerosis type 6 10.5 FUS TARDBP
23 perry syndrome 10.5 C9orf72 GRN TARDBP
24 expressive language disorder 10.5 FUS PSEN1 TARDBP
25 alzheimer disease 2 10.5 MAPT PSEN1 SMUG1
26 echolalia 10.4 CBS GRN MAPT PSEN1
27 vascular dementia 10.3 ACHE MAPT PSEN1
28 amyotrophic lateral sclerosis type 14 10.3 FUS TARDBP VCP
29 apraxia 10.3 C9orf72 GRN MAPT PSEN1
30 amyotrophic lateral sclerosis 18 10.3 C9orf72 FUS TARDBP
31 mixed liposarcoma 10.2 FUS PDGFB
32 lethal congenital contracture syndrome 1 10.2 FUS TARDBP
33 progressive muscular atrophy 10.2 C9orf72 TARDBP
34 alzheimer disease 3 10.1 PSEN1 RILPL1
35 connective tissue cancer 10.0 FUS PDGFB SMUG1
36 amyotrophic lateral sclerosis 21 10.0 C9orf72 FUS TARDBP VCP
37 autotopagnosia 10.0
38 progressive non-fluent aphasia 9.8 C9orf72 CHMP2B GRN MAPT PSEN1 VCP
39 behavioral variant of frontotemporal dementia 9.8 C9orf72 CHMP2B GRN MAPT PSEN1 VCP
40 chronic dacryocystitis 9.7 GRN SDC1
41 ideomotor apraxia 9.7 CBS FUS GRN MAPT PSEN1 TARDBP
42 agraphia 9.7 ACHE CBS GRN MAPT PSEN1 TARDBP
43 lateral sclerosis 9.7 C9orf72 FUS TARDBP TBK1 VCP
44 supranuclear palsy, progressive, 1 9.3 ACHE C9orf72 CBS GRN MAPT PSEN1
45 dementia, lewy body 9.2 ACHE CBS GRN MAPT PSEN1 SMUG1
46 motor neuron disease 9.2 C9orf72 FUS GRN MAPT TARDBP TBK1
47 speech and communication disorders 8.9 C9orf72 CBS FUS GRN MAPT PSEN1
48 basal ganglia disease 8.8 C9orf72 CBS CHMP2B FUS GRN MAPT
49 frontotemporal dementia and/or amyotrophic lateral sclerosis 1 8.7 C9orf72 CBS CHMP2B FUS GRN PSEN1
50 central nervous system disease 8.7 ACHE C9orf72 FUS GRN MAPT PSEN1

Graphical network of the top 20 diseases related to Nominal Aphasia:



Diseases related to Nominal Aphasia

Symptoms & Phenotypes for Nominal Aphasia

UMLS symptoms related to Nominal Aphasia:


scanning speech, other symbolic dysfunction

MGI Mouse Phenotypes related to Nominal Aphasia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.1 ACHE GLI3 GRN MAPT PDGFB PSEN1
2 hematopoietic system MP:0005397 10.07 PDGFB PSEN1 SDC1 TARDBP TBK1 VCP
3 mortality/aging MP:0010768 10.03 ACHE C9orf72 GLI3 GRN MAPT PDGFB
4 muscle MP:0005369 9.7 ACHE MAPT PDGFB PSEN1 TARDBP TCAP
5 nervous system MP:0003631 9.65 GLI3 GRN MAPT PDGFB ACHE C9orf72
6 no phenotypic analysis MP:0003012 9.23 ACHE C9orf72 GLI3 GRN MAPT PDGFB

Drugs & Therapeutics for Nominal Aphasia

Drugs for Nominal Aphasia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Benserazide Approved, Investigational Not Applicable 322-35-0
2
Dopamine Approved Not Applicable 51-61-6, 62-31-7 681
3
Cefpodoxime Approved, Vet_approved Not Applicable 82619-04-3, 80210-62-4 6335986
4
Levodopa Approved Not Applicable 59-92-7 6047
5
Menthol Approved Not Applicable 2216-51-5 16666
6 Dopamine agonists Not Applicable
7 Cefpodoxime proxetil Not Applicable
8 Neurotransmitter Agents Not Applicable
9 Dopamine Agents Not Applicable
10 Peripheral Nervous System Agents Not Applicable
11 Protective Agents Not Applicable
12 Antiparkinson Agents Not Applicable
13 Autonomic Agents Not Applicable

Interventional clinical trials:

(show all 21)
# Name Status NCT ID Phase Drugs
1 Targeted Electrotherapy for Aphasia Stroke Rehabilitation (TEASER) - Phase II Multi-Center Study Unknown status NCT02540109 Phase 2
2 Chronic Aphasia - Improved by Intensive Training and Electrical Brain Stimulation Unknown status NCT01221779 Phase 2
3 Chronic Aphasia - Improved by Intensive Training and Electrical Brain Stimulation (CATS) Unknown status NCT01924702 Phase 2
4 Effect of Verb Network Strengthening Treatment (VNeST) on Lexical Retrieval in Aphasia Completed NCT01300624 Phase 2
5 Effects of tDCS Versus HD-tDCS for Stroke Rehabilitation Completed NCT01651884 Phase 1
6 Exercise as an Adjuvant to Aphasia Therapy Completed NCT01113879 Phase 1
7 Overcoming Learned Non-Use in Chronic Aphasia Unknown status NCT02012374 Not Applicable
8 Speech Therapy for Aphasia: Comparing Two Treatments Completed NCT02153710 Not Applicable
9 Language Treatment for Progressive Aphasia Completed NCT00957710 Not Applicable
10 Cognitive Therapy to Improve Word Finding Completed NCT00494520 Not Applicable
11 Effect of Dopaminergic Medication on Recovery of Aphasia Completed NCT00941265 Not Applicable levodopa and benserazide;placebo
12 Classical Conditioning Training for Aphasia. A Telemedicine Approach. Completed NCT03381313 Not Applicable
13 Brain Connectivity Supporting Language Recovery in Aphasia Completed NCT02416856
14 Treatment for Word Retrieval Impairments in Aphasia Completed NCT00764400 Not Applicable
15 Language Assessment and Treatment Following Acquired Brain Injury Recruiting NCT03320954 Not Applicable
16 Finding the Right Words in Neurogenic Communication Disorders Recruiting NCT03568760 Not Applicable
17 Rehabilitation and Prophylaxis of Anomia in Primary Progressive Aphasia Recruiting NCT02675270 Not Applicable
18 Modeling Treated Recovery From Aphasia Recruiting NCT03416738 Not Applicable
19 Neurobiology of Language Recovery in Aphasia: Natural History and Treatment-Induced Recovery Active, not recruiting NCT01927302 Not Applicable
20 Analysis of Brain Activity to Uncover Brain-behavior Relationships Related to Therapy Outcomes in Aphasia Not yet recruiting NCT03550092 Not Applicable
21 Pairing Word Retrieval and Physical Endurance Tasks to Treat Anomia in People With Aphasia Withdrawn NCT03326687 Not Applicable

Search NIH Clinical Center for Nominal Aphasia

Cochrane evidence based reviews: anomia

Genetic Tests for Nominal Aphasia

Anatomical Context for Nominal Aphasia

MalaCards organs/tissues related to Nominal Aphasia:

41
Brain, Temporal Lobe

Publications for Nominal Aphasia

Articles related to Nominal Aphasia:

# Title Authors Year
1
Nominal aphasia following a radical mastoidectomy. ( 3701207 )
1986
2
Autotopagnosia. Occurrence in a patient without nominal aphasia and with an intact ability to point to parts of animals and objects. ( 4075073 )
1985
3
Acute memory loss and nominal aphasia caused by phenylpropanolamine. ( 6505775 )
1984
4
Nominal aphasia in dementia. ( 5702274 )
1968
5
Nominal aphasia due to extradural temporal lobe abscess. ( 13043172 )
1953

Variations for Nominal Aphasia

Expression for Nominal Aphasia

Search GEO for disease gene expression data for Nominal Aphasia.

Pathways for Nominal Aphasia

GO Terms for Nominal Aphasia

Cellular components related to Nominal Aphasia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 ACHE AMY2A C9orf72 GRN HTN3 MAPT
2 growth cone GO:0030426 9.33 C9orf72 MAPT PSEN1
3 main axon GO:0044304 8.62 C9orf72 MAPT

Biological processes related to Nominal Aphasia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 9.56 MAPT PDGFB TARDBP TBK1
2 regulation of neuron death GO:1901214 9.4 RILPL1 TBK1
3 stress granule assembly GO:0034063 9.37 C9orf72 MAPT
4 negative regulation of protein phosphorylation GO:0001933 9.33 C9orf72 PSEN1 TARDBP
5 amyloid precursor protein metabolic process GO:0042982 9.32 ACHE PSEN1
6 astrocyte activation GO:0048143 8.96 MAPT PSEN1
7 autophagy GO:0006914 8.92 C9orf72 CHMP2B PSEN1 VCP

Molecular functions related to Nominal Aphasia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.89 ACHE C9orf72 CBS CHMP2B FUS GLI3
2 identical protein binding GO:0042802 9.23 CBS FUS MAPT PDGFB SDC1 TARDBP

Sources for Nominal Aphasia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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