MCID: NNF001
MIFTS: 22

Non-Functioning Pancreatic Endocrine Tumor

Categories: Cancer diseases, Endocrine diseases, Rare diseases

Aliases & Classifications for Non-Functioning Pancreatic Endocrine Tumor

MalaCards integrated aliases for Non-Functioning Pancreatic Endocrine Tumor:

Name: Non-Functioning Pancreatic Endocrine Tumor 12 15
Non Functioning Pancreatic Endocrine Tumor 52 43 71
Non-Functioning Endocrine Pancreatic Tumors 52
Non-Functioning Epts 52

Classifications:



External Ids:

Disease Ontology 12 DOID:7698
MeSH 43 C536126
NCIt 49 C45837
UMLS 71 C1334977

Summaries for Non-Functioning Pancreatic Endocrine Tumor

MalaCards based summary : Non-Functioning Pancreatic Endocrine Tumor, also known as non functioning pancreatic endocrine tumor, is related to non-functioning neuroendocrine tumor of pancreas and auditory system benign neoplasm. An important gene associated with Non-Functioning Pancreatic Endocrine Tumor is PPY (Pancreatic Polypeptide). Affiliated tissues include lymph node, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Non-Functioning Pancreatic Endocrine Tumor

Diseases related to Non-Functioning Pancreatic Endocrine Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 124)
# Related Disease Score Top Affiliating Genes
1 non-functioning neuroendocrine tumor of pancreas 11.7
2 auditory system benign neoplasm 10.3 PPY CHGA
3 auditory system cancer 10.3 PPY CHGA
4 middle ear adenoma 10.3 PPY CHGA
5 sensory organ benign neoplasm 10.3 PPY CHGA
6 small cell carcinoma 10.2 GAST CHGA
7 autoimmune atrophic gastritis 10.2 GAST CHGA
8 mixed ductal-endocrine carcinoma 10.2 GAST CHGA
9 goblet cell carcinoid 10.2 GAST CHGA
10 persistent generalized lymphadenopathy 10.2 MEN1 CHGA
11 diabetic autonomic neuropathy 10.2 PPY GAST
12 sclerosing hemangioma 10.2 GAST CHGA
13 adrenal cortical carcinoma 10.1 MEN1 CHGA
14 acinar cell carcinoma 10.1 GAST CHGA
15 adrenal cortical adenoma 10.1 MEN1 CHGA
16 jejunal somatostatinoma 10.1 SST PPY
17 pancreatic somatostatinoma 10.1 SST PPY
18 duodenal benign neoplasm 10.1 SST CHGA
19 ampulla of vater neoplasm 10.1 SST CHGA
20 carotid body cancer 10.1 SST CHGA
21 gastric hemangioma 10.1 SST CHGA
22 binswanger's disease 10.1 SST CHGA
23 meckel diverticulum 10.1 SST CHGA
24 primary pigmented nodular adrenocortical disease 10.1 MEN1 CHGA
25 adrenal medulla cancer 10.1 SST CHGA
26 autonomic nervous system benign neoplasm 10.1 SST CHGA
27 peripheral nervous system benign neoplasm 10.1 SST CHGA
28 pituitary infarct 10.1 SST MEN1
29 pancreatoblastoma 10.0 SST CHGA
30 small intestine neuroendocrine neoplasm 10.0 SST MEN1
31 parathyroid gland disease 10.0 MEN1 GAST
32 hormone producing pituitary cancer 10.0 SST MEN1
33 pituitary apoplexy 10.0 SST MEN1
34 rectum neuroendocrine neoplasm 10.0 SST GAST
35 hyperpituitarism 10.0 SST MEN1
36 subependymal giant cell astrocytoma 10.0 SST CHGA
37 small intestine cancer 10.0 MEN1 GAST
38 acth-secreting pituitary adenoma 10.0 SST MEN1
39 postgastrectomy syndrome 10.0 SST GAST
40 malignant pheochromocytoma 10.0 SST CHGA
41 gastric antral vascular ectasia 10.0 SST GAST
42 pituitary tumors 10.0 SST MEN1
43 growth hormone secreting pituitary adenoma 10.0 SST MEN1
44 pulmonary blastoma 10.0 SST CHGA
45 duodenogastric reflux 10.0 SST GAST
46 cardiovascular organ benign neoplasm 10.0 MEN1 CHGA
47 pituitary adenoma 1, multiple types 10.0 SST MEN1
48 endometrial small cell carcinoma 10.0 PPY GAST CHGA
49 dumping syndrome 10.0 SST GAST
50 functioning pituitary adenoma 10.0 SST MEN1

Graphical network of the top 20 diseases related to Non-Functioning Pancreatic Endocrine Tumor:



Diseases related to Non-Functioning Pancreatic Endocrine Tumor

Symptoms & Phenotypes for Non-Functioning Pancreatic Endocrine Tumor

GenomeRNAi Phenotypes related to Non-Functioning Pancreatic Endocrine Tumor according to GeneCards Suite gene sharing:

26 (show all 30)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-1 9.98 LSM1
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-115 9.98 FNTA
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-116 9.98 FNTA NINJ1
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-122 9.98 NINJ1
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-123 9.98 CHGA
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 9.98 FNTA NINJ1
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-165 9.98 FNTA
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-168 9.98 FNTA
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-174 9.98 CHGA
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-176 9.98 CHGA
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-183 9.98 LSM1
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-215 9.98 CHGA
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-40 9.98 FNTA
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-42 9.98 FNTA
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-61 9.98 CHGA LSM1
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-70 9.98 CHGA
17 Decreased shRNA abundance (Z-score < -2) GR00366-A-78 9.98 LSM1
18 Decreased shRNA abundance (Z-score < -2) GR00366-A-85 9.98 NINJ1
19 Increased shRNA abundance (Z-score > 2) GR00366-A-111 9.4 MEN1
20 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.4 LSM1
21 Increased shRNA abundance (Z-score > 2) GR00366-A-116 9.4 LSM1
22 Increased shRNA abundance (Z-score > 2) GR00366-A-119 9.4 FNTA
23 Increased shRNA abundance (Z-score > 2) GR00366-A-128 9.4 MEN1
24 Increased shRNA abundance (Z-score > 2) GR00366-A-153 9.4 MEN1
25 Increased shRNA abundance (Z-score > 2) GR00366-A-156 9.4 FNTA
26 Increased shRNA abundance (Z-score > 2) GR00366-A-23 9.4 FNTA
27 Increased shRNA abundance (Z-score > 2) GR00366-A-47 9.4 MEN1
28 Increased shRNA abundance (Z-score > 2) GR00366-A-84 9.4 FNTA
29 Increased shRNA abundance (Z-score > 2) GR00366-A-94 9.4 FNTA
30 Increased shRNA abundance (Z-score > 2) GR00366-A-98 9.4 MEN1

MGI Mouse Phenotypes related to Non-Functioning Pancreatic Endocrine Tumor:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 mortality/aging MP:0010768 9.17 CHGA FNTA GAST LSM1 MEN1 NINJ1

Drugs & Therapeutics for Non-Functioning Pancreatic Endocrine Tumor

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Clinical Effectiveness of Serum Chromogranin A (CgA) Levels on Diagnostic Relevance, Response After Surgical Resection and Recurrence of Pancreatic Endocrine Tumors (PET) Unknown status NCT02759718 Phase 4
2 A Prospective Evaluation of the Management of Sporadic Asymptomatic Nonfunctioning Pancreatic Neuroendocrine Neoplasms ≤ 2 cm Recruiting NCT03084770
3 Diagnostic Accuracy of 68Gallium Positron Emission Tomography/ Magnetic Resonance Imaging (68Ga PET/MRI), Endoscopic Ultrasound (EUS) and Computed Tomography in the Assessment of Lymph Node Metastases by Nonfunctioning Pancreatic Neuroendocrine Neoplasms Recruiting NCT03918759

Search NIH Clinical Center for Non-Functioning Pancreatic Endocrine Tumor

Cochrane evidence based reviews: non functioning pancreatic endocrine tumor

Genetic Tests for Non-Functioning Pancreatic Endocrine Tumor

Anatomical Context for Non-Functioning Pancreatic Endocrine Tumor

MalaCards organs/tissues related to Non-Functioning Pancreatic Endocrine Tumor:

40
Lymph Node

Publications for Non-Functioning Pancreatic Endocrine Tumor

Articles related to Non-Functioning Pancreatic Endocrine Tumor:

# Title Authors PMID Year
1
Pancreatic involvement in 11 cases of Von Hippel-Lindau disease. 61
22353527 2012
2
Intracranial ectopic pancreatic tissue. 61
21099298 2010
3
Nonfunctioning pancreatic endocrine tumors. An immunohistochemical and electron microscopic analysis of 26 cases. 61
1317556 1992

Variations for Non-Functioning Pancreatic Endocrine Tumor

Expression for Non-Functioning Pancreatic Endocrine Tumor

Search GEO for disease gene expression data for Non-Functioning Pancreatic Endocrine Tumor.

Pathways for Non-Functioning Pancreatic Endocrine Tumor

GO Terms for Non-Functioning Pancreatic Endocrine Tumor

Molecular functions related to Non-Functioning Pancreatic Endocrine Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.8 SST PPY GAST

Sources for Non-Functioning Pancreatic Endocrine Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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