MCID: NNF001
MIFTS: 21

Non-Functioning Pancreatic Endocrine Tumor

Categories: Cancer diseases, Endocrine diseases, Rare diseases

Aliases & Classifications for Non-Functioning Pancreatic Endocrine Tumor

MalaCards integrated aliases for Non-Functioning Pancreatic Endocrine Tumor:

Name: Non-Functioning Pancreatic Endocrine Tumor 12 15
Non Functioning Pancreatic Endocrine Tumor 20 44 71
Non-Functioning Endocrine Pancreatic Tumors 20
Non-Functioning Epts 20

Classifications:



External Ids:

Disease Ontology 12 DOID:7698
MeSH 44 C536126
NCIt 50 C45837
UMLS 71 C1334977

Summaries for Non-Functioning Pancreatic Endocrine Tumor

MalaCards based summary : Non-Functioning Pancreatic Endocrine Tumor, also known as non functioning pancreatic endocrine tumor, is related to non-functioning neuroendocrine tumor of pancreas and auditory system benign neoplasm. An important gene associated with Non-Functioning Pancreatic Endocrine Tumor is PPY (Pancreatic Polypeptide). Affiliated tissues include lymph node, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Non-Functioning Pancreatic Endocrine Tumor

Diseases related to Non-Functioning Pancreatic Endocrine Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 125)
# Related Disease Score Top Affiliating Genes
1 non-functioning neuroendocrine tumor of pancreas 11.5
2 auditory system benign neoplasm 10.2 PPY CHGA
3 auditory system cancer 10.2 PPY CHGA
4 middle ear adenoma 10.2 PPY CHGA
5 sensory organ benign neoplasm 10.2 PPY CHGA
6 small cell carcinoma 10.2 GAST CHGA
7 autoimmune atrophic gastritis 10.2 GAST CHGA
8 persistent generalized lymphadenopathy 10.2 MEN1 CHGA
9 mixed ductal-endocrine carcinoma 10.2 GAST CHGA
10 diabetic autonomic neuropathy 10.2 PPY GAST
11 goblet cell carcinoid 10.2 GAST CHGA
12 adrenal cortical adenoma 10.1 MEN1 CHGA
13 jejunal somatostatinoma 10.1 SST PPY
14 parathyroid gland disease 10.1 MEN1 GAST
15 acinar cell carcinoma 10.1 GAST CHGA
16 pancreatic somatostatinoma 10.1 SST PPY
17 multiple endocrine neoplasia, type iia 10.1 MEN1 CHGA
18 small intestine cancer 10.1 MEN1 GAST
19 pituitary infarct 10.1 SST MEN1
20 small intestine neuroendocrine neoplasm 10.1 SST MEN1
21 diamond-blackfan anemia 5 10.1 SST PPY
22 ampulla of vater neoplasm 10.1 SST CHGA
23 carotid body cancer 10.1 SST CHGA
24 hormone producing pituitary cancer 10.1 SST MEN1
25 duodenal benign neoplasm 10.1 SST CHGA
26 pituitary apoplexy 10.1 SST MEN1
27 laryngeal neuroendocrine tumor 10.1 SST CHGA
28 hyperpituitarism 10.1 SST MEN1
29 gastric hemangioma 10.1 SST CHGA
30 cardiovascular organ benign neoplasm 10.1 MEN1 CHGA
31 ectopic cushing syndrome 10.1 SST CHGA
32 binswanger's disease 10.0 SST CHGA
33 pituitary adenoma 1, multiple types 10.0 SST MEN1
34 meckel diverticulum 10.0 SST CHGA
35 adrenal medulla cancer 10.0 SST CHGA
36 rectum neuroendocrine neoplasm 10.0 SST GAST
37 pituitary tumors 10.0 SST MEN1
38 autonomic nervous system benign neoplasm 10.0 SST CHGA
39 peripheral nervous system benign neoplasm 10.0 SST CHGA
40 primary pigmented nodular adrenocortical disease 10.0 MEN1 CHGA
41 pancreatoblastoma 10.0 SST CHGA
42 postgastrectomy syndrome 10.0 SST GAST
43 pituitary carcinoma 10.0 SST CHGA
44 gastric antral vascular ectasia 10.0 SST GAST
45 functioning pituitary adenoma 10.0 SST MEN1
46 duodenogastric reflux 10.0 SST GAST
47 acth-secreting pituitary adenoma 10.0 SST MEN1
48 malignant pheochromocytoma 10.0 SST CHGA
49 growth hormone secreting pituitary adenoma 10.0 SST MEN1
50 subependymal giant cell astrocytoma 10.0 SST CHGA

Graphical network of the top 20 diseases related to Non-Functioning Pancreatic Endocrine Tumor:



Diseases related to Non-Functioning Pancreatic Endocrine Tumor

Symptoms & Phenotypes for Non-Functioning Pancreatic Endocrine Tumor

GenomeRNAi Phenotypes related to Non-Functioning Pancreatic Endocrine Tumor according to GeneCards Suite gene sharing:

26 (show all 12)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-111 9.4 MEN1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.4 LSM1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-116 9.4 LSM1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-119 9.4 FNTA
5 Increased shRNA abundance (Z-score > 2) GR00366-A-128 9.4 MEN1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-153 9.4 MEN1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-156 9.4 FNTA
8 Increased shRNA abundance (Z-score > 2) GR00366-A-23 9.4 FNTA
9 Increased shRNA abundance (Z-score > 2) GR00366-A-47 9.4 MEN1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-84 9.4 FNTA
11 Increased shRNA abundance (Z-score > 2) GR00366-A-94 9.4 FNTA
12 Increased shRNA abundance (Z-score > 2) GR00366-A-98 9.4 MEN1

Drugs & Therapeutics for Non-Functioning Pancreatic Endocrine Tumor

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Clinical Effectiveness of Serum Chromogranin A (CgA) Levels on Diagnostic Relevance, Response After Surgical Resection and Recurrence of Pancreatic Endocrine Tumors (PET) Unknown status NCT02759718 Phase 4
2 Diagnostic Accuracy of 68Gallium Positron Emission Tomography/ Magnetic Resonance Imaging (68Ga PET/MRI), Endoscopic Ultrasound (EUS) and Computed Tomography in the Assessment of Lymph Node Metastases by Nonfunctioning Pancreatic Neuroendocrine Neoplasms Recruiting NCT03918759
3 A Prospective Evaluation of the Management of Sporadic Asymptomatic Nonfunctioning Pancreatic Neuroendocrine Neoplasms ≤ 2 cm Recruiting NCT03084770

Search NIH Clinical Center for Non-Functioning Pancreatic Endocrine Tumor

Cochrane evidence based reviews: non functioning pancreatic endocrine tumor

Genetic Tests for Non-Functioning Pancreatic Endocrine Tumor

Anatomical Context for Non-Functioning Pancreatic Endocrine Tumor

MalaCards organs/tissues related to Non-Functioning Pancreatic Endocrine Tumor:

40
Lymph Node

Publications for Non-Functioning Pancreatic Endocrine Tumor

Articles related to Non-Functioning Pancreatic Endocrine Tumor:

# Title Authors PMID Year
1
Pancreatic involvement in 11 cases of Von Hippel-Lindau disease. 61
22353527 2012
2
Intracranial ectopic pancreatic tissue. 61
21099298 2010
3
Nonfunctioning pancreatic endocrine tumors. An immunohistochemical and electron microscopic analysis of 26 cases. 61
1317556 1992

Variations for Non-Functioning Pancreatic Endocrine Tumor

Expression for Non-Functioning Pancreatic Endocrine Tumor

Search GEO for disease gene expression data for Non-Functioning Pancreatic Endocrine Tumor.

Pathways for Non-Functioning Pancreatic Endocrine Tumor

GO Terms for Non-Functioning Pancreatic Endocrine Tumor

Molecular functions related to Non-Functioning Pancreatic Endocrine Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.8 SST PPY GAST

Sources for Non-Functioning Pancreatic Endocrine Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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