MCID: NNF001
MIFTS: 35

Non-Functioning Pancreatic Endocrine Tumor

Categories: Rare diseases, Cancer diseases, Endocrine diseases

Aliases & Classifications for Non-Functioning Pancreatic Endocrine Tumor

MalaCards integrated aliases for Non-Functioning Pancreatic Endocrine Tumor:

Name: Non-Functioning Pancreatic Endocrine Tumor 12 15
Non Functioning Pancreatic Endocrine Tumor 53 44 73
Non-Functioning Endocrine Pancreatic Tumors 53
Non-Functioning Epts 53

Classifications:



External Ids:

Disease Ontology 12 DOID:7698
MeSH 44 C536126
NCIt 50 C45837
UMLS 73 C1334977

Summaries for Non-Functioning Pancreatic Endocrine Tumor

MalaCards based summary : Non-Functioning Pancreatic Endocrine Tumor, also known as non functioning pancreatic endocrine tumor, is related to non-functioning neuroendocrine tumor of pancreas and diarrhea 4, malabsorptive, congenital. An important gene associated with Non-Functioning Pancreatic Endocrine Tumor is SOX17 (SRY-Box 17), and among its related pathways/superpathways are Developmental Biology and Mesodermal Commitment Pathway. The drugs Pancrelipase and pancreatin have been mentioned in the context of this disorder. Related phenotypes are behavior/neurological and cellular

Related Diseases for Non-Functioning Pancreatic Endocrine Tumor

Diseases related to Non-Functioning Pancreatic Endocrine Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 87)
# Related Disease Score Top Affiliating Genes
1 non-functioning neuroendocrine tumor of pancreas 11.4
2 diarrhea 4, malabsorptive, congenital 10.8 CHGA NEUROG3
3 esophageal neuroendocrine tumor 10.7 CHGA SYP
4 ureter small cell carcinoma 10.7 CHGA SYP
5 urinary bladder small cell neuroendocrine carcinoma 10.7 CHGA SYP
6 ovarian large-cell neuroendocrine carcinoma 10.7 CHGA SYP
7 auditory system cancer 10.7 CHGA SYP
8 adenoma of the pancreas 10.7 CHGA SYP
9 acinar cell cystadenocarcinoma 10.7 CHGA SYP
10 peritoneal serous adenocarcinoma 10.7 CHGA SYP
11 cellular ependymoma 10.7 CHGA SYP
12 gallbladder small cell carcinoma 10.7 CHGA SYP
13 primary hepatic neuroendocrine carcinoma 10.7 CHGA SYP
14 small cell carcinoma of the bladder 10.7 CHGA SYP
15 gastrointestinal neuroendocrine tumor 10.6 CHGA SYP
16 pulmonary large cell neuroendocrine carcinoma 10.6 CHGA SYP
17 atypical follicular adenoma 10.6 CHGA SYP
18 chordoid meningioma 10.6 CHGA SYP
19 central nervous system germ cell tumor 10.6 POU5F1 SOX2
20 ovarian embryonal carcinoma 10.6 POU5F1 SOX2
21 olfactory nerve neoplasm 10.6 CHGA SYP
22 cauda equina neoplasm 10.6 CHGA SYP
23 pancreatic serous cystadenoma 10.6 CHGA SYP
24 conventional angiosarcoma 10.6 CHGA SYP
25 autoimmune atrophic gastritis 10.6 CHGA GAST
26 nodular ganglioneuroblastoma 10.6 CHGA SYP
27 pulmonary sclerosing hemangioma 10.6 CHGA SYP
28 gastrointestinal neuroendocrine benign tumor 10.6 CHGA GAST
29 pineocytoma 10.6 CHGA SYP
30 respiratory system benign neoplasm 10.6 CHGA SYP
31 gastric squamous cell carcinoma 10.6 CHGA SYP
32 gastric neuroendocrine neoplasm 10.6 CHGA GAST
33 gastric small cell carcinoma 10.6 CHGA SYP
34 pancreatoblastoma 10.6 CHGA SYP
35 subependymoma 10.6 CHGA SYP
36 carcinoid tumors, intestinal 10.6 CHGA SYP
37 pulmonary blastoma 10.6 CHGA SYP
38 goblet cell carcinoid 10.6 CHGA GAST
39 ureter, cancer of 10.5 CHGA SYP
40 tanycytic ependymoma 10.5 CHGA SYP
41 papillary ependymoma 10.5 CHGA SYP
42 hyperinsulinemic hypoglycemia, familial, 2 10.5 CHGA GAST
43 pleomorphic xanthoastrocytoma 10.5 CHGA SYP
44 malignant teratoma 10.5 POU5F1 SYP
45 vipoma 10.5 CHGA GAST
46 sclerosing hemangioma 10.5 CHGA SYP
47 central neurocytoma 10.5 CHGA SYP
48 pancreatic cystadenocarcinoma 10.5 CHGA SYP
49 binswanger's disease 10.5 CHGA SYP
50 carcinoid syndrome 10.5 CHGA SYP

Graphical network of the top 20 diseases related to Non-Functioning Pancreatic Endocrine Tumor:



Diseases related to Non-Functioning Pancreatic Endocrine Tumor

Symptoms & Phenotypes for Non-Functioning Pancreatic Endocrine Tumor

MGI Mouse Phenotypes related to Non-Functioning Pancreatic Endocrine Tumor:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.13 FOXA2 GHRL NKX6-1 NKX6-2 POU5F1 PPY
2 cellular MP:0005384 10.06 SOX2 TOP2B FOXA2 NEUROG3 NKX6-1 NKX6-2
3 endocrine/exocrine gland MP:0005379 10.02 CHGA FOXA2 GAST GHRL NEUROG3 NKX6-1
4 mortality/aging MP:0010768 10 CHGA FOXA2 GAST NEUROG3 NKX6-1 NKX6-2
5 digestive/alimentary MP:0005381 9.97 FOXA2 GAST GHRL NEUROG3 POU5F1 PTF1A
6 nervous system MP:0003631 9.76 NKX6-2 POU5F1 PTF1A SOX2 SYP TOP2B
7 no phenotypic analysis MP:0003012 9.43 CHGA NEUROG3 NKX6-1 PTF1A SOX17 SOX2
8 normal MP:0002873 9.32 FOXA2 GHRL NEUROG3 NKX6-2 POU5F1 PTF1A

Drugs & Therapeutics for Non-Functioning Pancreatic Endocrine Tumor

Drugs for Non-Functioning Pancreatic Endocrine Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pancrelipase Approved, Investigational Phase 4 53608-75-6
2 pancreatin Phase 4
3 Fluorodeoxyglucose F18 Phase 4
4
Everolimus Approved Phase 3 159351-69-6 6442177
5
Sirolimus Approved, Investigational Phase 3 53123-88-9 5284616 6436030 46835353
6
Somatostatin Approved, Investigational Phase 3 38916-34-6, 51110-01-1 53481605
7 Hormone Antagonists Phase 3
8 Hormones Phase 3
9 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
10 Immunosuppressive Agents Phase 3
11
Dacarbazine Approved, Investigational Phase 1 4342-03-4 5351166
12
Temozolomide Approved, Investigational Phase 1 85622-93-1 5394
13
Trifluridine Approved, Investigational Phase 1 70-00-8 6256
14 Alkylating Agents Phase 1
15 Anti-Infective Agents Phase 1
16 Antimetabolites Phase 1
17 Antiviral Agents Phase 1
18 Antineoplastic Agents, Alkylating Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Clinical Effectiveness of Serum Chromogranin A Levels on Diagnostic of Pancreatic Neuroendocrine Tumors Unknown status NCT02759718 Phase 4
2 Nonfunctional Pancreatic NET and PET Imaging Recruiting NCT02621541 Phase 4
3 Non-functioning Pancreatic Neuroendocrine Tumors in MEN1: Somatostatin Analogs Versus NO Treatment Not yet recruiting NCT02705651 Phase 3 Somatostatin-Analog
4 Cabozantinib S-malate in Treating Patients With Neuroendocrine Tumors Previously Treated With Everolimus That Are Locally Advanced, Metastatic, or Cannot Be Removed by Surgery Not yet recruiting NCT03375320 Phase 3 Cabozantinib S-malate
5 Safety of TAS-102 in Combination With Temozolomide for Metastatic Pancreatic NETs Suspended NCT02943733 Phase 1 TAS-102;Temozolomide;Filgrastim;Pegfilgrastim
6 Veliparib, Capecitabine, and Temozolomide in Patients With Advanced, Metastatic, and Recurrent Neuroendocrine Tumor Withdrawn NCT02831179 Phase 1 Capecitabine;Temozolomide;Veliparib
7 Asymptomatic Small Pancreatic Endocrine Neoplasms. Recruiting NCT03084770

Search NIH Clinical Center for Non-Functioning Pancreatic Endocrine Tumor

Cochrane evidence based reviews: non functioning pancreatic endocrine tumor

Genetic Tests for Non-Functioning Pancreatic Endocrine Tumor

Anatomical Context for Non-Functioning Pancreatic Endocrine Tumor

Publications for Non-Functioning Pancreatic Endocrine Tumor

Articles related to Non-Functioning Pancreatic Endocrine Tumor:

# Title Authors Year
1
Non-functioning pancreatic endocrine tumors: eleven-year experience in a single institute. ( 24965405 )
2014

Variations for Non-Functioning Pancreatic Endocrine Tumor

Expression for Non-Functioning Pancreatic Endocrine Tumor

Search GEO for disease gene expression data for Non-Functioning Pancreatic Endocrine Tumor.

Pathways for Non-Functioning Pancreatic Endocrine Tumor

GO Terms for Non-Functioning Pancreatic Endocrine Tumor

Cellular components related to Non-Functioning Pancreatic Endocrine Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription factor complex GO:0005667 8.8 PTF1A SOX17 SOX2

Biological processes related to Non-Functioning Pancreatic Endocrine Tumor according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 cell differentiation GO:0030154 9.98 FOXA2 NEUROG3 NKX6-1 NKX6-2 PTF1A
2 transcription by RNA polymerase II GO:0006366 9.91 NEUROG3 NKX6-1 POU5F1 PTF1A SOX2
3 multicellular organism development GO:0007275 9.87 FOXA2 NEUROG3 NKX6-1 NKX6-2 POU5F1 PTF1A
4 negative regulation of transcription by RNA polymerase II GO:0000122 9.85 NEUROG3 NKX6-1 NKX6-2 POU5F1 SOX17 SOX2
5 forebrain development GO:0030900 9.67 NEUROG3 SOX2 TOP2B
6 positive regulation of cell differentiation GO:0045597 9.61 NEUROG3 SOX17 SOX2
7 oligodendrocyte differentiation GO:0048709 9.57 NKX6-1 NKX6-2
8 pancreas development GO:0031016 9.56 NKX6-1 PTF1A
9 hindbrain development GO:0030902 9.55 NEUROG3 PTF1A
10 mRNA transcription by RNA polymerase II GO:0042789 9.54 POU5F1 SOX17
11 positive regulation of transcription by RNA polymerase II GO:0045944 9.5 FOXA2 NEUROG3 NKX6-1 POU5F1 PTF1A SOX17
12 positive regulation of glial cell differentiation GO:0045687 9.48 NKX6-1 NKX6-2
13 endodermal cell fate specification GO:0001714 9.46 POU5F1 SOX2
14 regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification GO:0021913 9.4 NKX6-1 NKX6-2
15 negative regulation of glial cell differentiation GO:0045686 9.26 NKX6-1 NKX6-2
16 regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification GO:0021912 9.16 NKX6-1 NKX6-2
17 endocrine pancreas development GO:0031018 8.92 FOXA2 NEUROG3 NKX6-1 NKX6-2
18 regulation of transcription, DNA-templated GO:0006355 10.13 FOXA2 NEUROG3 NKX6-1 NKX6-2 POU5F1 PTF1A
19 transcription, DNA-templated GO:0006351 10.12 FOXA2 NEUROG3 NKX6-1 POU5F1 PTF1A SOX17

Molecular functions related to Non-Functioning Pancreatic Endocrine Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA binding GO:0003677 9.81 FOXA2 NEUROG3 NKX6-1 NKX6-2 POU5F1 PTF1A
2 DNA binding transcription factor activity GO:0003700 9.8 FOXA2 NEUROG3 NKX6-1 NKX6-2 POU5F1 SOX17
3 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.67 FOXA2 NEUROG3 NKX6-1 NKX6-2
4 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding GO:0001078 9.58 NEUROG3 NKX6-1 NKX6-2
5 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0000981 9.56 FOXA2 NEUROG3 NKX6-1 NKX6-2 POU5F1 PTF1A
6 hormone activity GO:0005179 9.5 GAST GHRL PPY
7 miRNA binding GO:0035198 9.43 POU5F1 SOX2
8 sequence-specific DNA binding GO:0043565 9.17 FOXA2 NKX6-1 NKX6-2 POU5F1 PTF1A SOX17

Sources for Non-Functioning Pancreatic Endocrine Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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