MCID: NNF001
MIFTS: 37

Non-Functioning Pancreatic Endocrine Tumor

Categories: Cancer diseases, Endocrine diseases, Rare diseases

Aliases & Classifications for Non-Functioning Pancreatic Endocrine Tumor

MalaCards integrated aliases for Non-Functioning Pancreatic Endocrine Tumor:

Name: Non-Functioning Pancreatic Endocrine Tumor 12 15
Non Functioning Pancreatic Endocrine Tumor 54 45 74
Non-Functioning Endocrine Pancreatic Tumors 54
Non-Functioning Epts 54

Classifications:



External Ids:

Disease Ontology 12 DOID:7698
MeSH 45 C536126
NCIt 51 C45837
UMLS 74 C1334977

Summaries for Non-Functioning Pancreatic Endocrine Tumor

MalaCards based summary : Non-Functioning Pancreatic Endocrine Tumor, also known as non functioning pancreatic endocrine tumor, is related to non-functioning neuroendocrine tumor of pancreas and diarrhea 4, malabsorptive, congenital. An important gene associated with Non-Functioning Pancreatic Endocrine Tumor is SOX17 (SRY-Box 17), and among its related pathways/superpathways are Developmental Biology and Mesodermal Commitment Pathway. The drugs Pancrelipase and pancreatin have been mentioned in the context of this disorder. Affiliated tissues include lymph node, pancreas and kidney, and related phenotypes are behavior/neurological and endocrine/exocrine gland

Related Diseases for Non-Functioning Pancreatic Endocrine Tumor

Diseases related to Non-Functioning Pancreatic Endocrine Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 95)
# Related Disease Score Top Affiliating Genes
1 non-functioning neuroendocrine tumor of pancreas 11.6
2 diarrhea 4, malabsorptive, congenital 10.4 CHGA NEUROG3
3 gastrinoma 10.3 CHGA GAST
4 ureter small cell carcinoma 10.3 CHGA SYP
5 autoimmune atrophic gastritis 10.3 CHGA GAST
6 esophageal neuroendocrine tumor 10.3 CHGA SYP
7 central nervous system germ cell tumor 10.3 POU5F1 SOX2
8 urinary bladder small cell neuroendocrine carcinoma 10.3 CHGA SYP
9 ovarian large-cell neuroendocrine carcinoma 10.3 CHGA SYP
10 ovarian embryonal carcinoma 10.3 POU5F1 SOX2
11 auditory system cancer 10.3 CHGA SYP
12 acinar cell cystadenocarcinoma 10.3 CHGA SYP
13 peritoneal serous adenocarcinoma 10.3 CHGA SYP
14 gastrointestinal neuroendocrine benign tumor 10.3 CHGA GAST
15 cellular ependymoma 10.3 CHGA SYP
16 primary hepatic neuroendocrine carcinoma 10.3 CHGA SYP
17 small cell carcinoma of the bladder 10.3 CHGA SYP
18 maturity-onset diabetes of the young, type 8, with exocrine dysfunction 10.3 POU5F1 SOX2
19 gastrointestinal neuroendocrine tumor 10.3 CHGA SYP
20 gastric neuroendocrine neoplasm 10.3 CHGA GAST
21 pulmonary large cell neuroendocrine carcinoma 10.3 CHGA SYP
22 large cell neuroendocrine carcinoma 10.3 CHGA SYP
23 gallbladder small cell carcinoma 10.3 CHGA SYP
24 atypical follicular adenoma 10.3 CHGA SYP
25 chordoid meningioma 10.3 CHGA SYP
26 goblet cell carcinoid 10.3 CHGA GAST
27 olfactory groove meningioma 10.3 CHGA SYP
28 cauda equina neoplasm 10.3 CHGA SYP
29 pancreatic serous cystadenoma 10.2 CHGA SYP
30 cystadenoma 10.2 CHGA SYP
31 conventional angiosarcoma 10.2 CHGA SYP
32 insulinomatosis and diabetes mellitus 10.2 CHGA GAST
33 olfactory nerve neoplasm 10.2 CHGA SYP
34 autonomic nervous system benign neoplasm 10.2 CHGA SYP
35 nodular ganglioneuroblastoma 10.2 CHGA SYP
36 pulmonary sclerosing hemangioma 10.2 CHGA SYP
37 sclerosing hemangioma 10.2 CHGA SYP
38 pineocytoma 10.2 CHGA SYP
39 vipoma 10.2 CHGA GAST
40 gastric small cell carcinoma 10.2 CHGA SYP
41 pancreatoblastoma 10.2 CHGA SYP
42 subependymoma 10.2 CHGA SYP
43 phosphoglycerate dehydrogenase deficiency 10.2 POU5F1 SOX2
44 carcinoid tumors, intestinal 10.2 CHGA SYP
45 respiratory system benign neoplasm 10.2 CHGA SYP
46 anterior cranial fossa meningioma 10.2 CHGA SYP
47 gastric squamous cell carcinoma 10.2 CHGA SYP
48 pulmonary blastoma 10.2 CHGA SYP
49 pleomorphic xanthoastrocytoma 10.2 CHGA SYP
50 tanycytic ependymoma 10.2 CHGA SYP

Graphical network of the top 20 diseases related to Non-Functioning Pancreatic Endocrine Tumor:



Diseases related to Non-Functioning Pancreatic Endocrine Tumor

Symptoms & Phenotypes for Non-Functioning Pancreatic Endocrine Tumor

MGI Mouse Phenotypes related to Non-Functioning Pancreatic Endocrine Tumor:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.11 FOXA2 GHRL NKX6-1 NKX6-2 POU5F1 PPY
2 endocrine/exocrine gland MP:0005379 10.07 CHGA FOXA2 GAST GHRL NEUROG3 NKX6-1
3 cellular MP:0005384 10.03 FOXA2 NEUROG3 NKX6-1 NKX6-2 POU5F1 PTF1A
4 digestive/alimentary MP:0005381 10.01 FOXA2 GAST GHRL NEUROG3 POU5F1 PTF1A
5 homeostasis/metabolism MP:0005376 9.97 CHGA FOXA2 GAST GHRL NEUROG3 NKX6-1
6 mortality/aging MP:0010768 9.96 CHGA FOXA2 GAST NEUROG3 NKX6-1 NKX6-2
7 nervous system MP:0003631 9.76 CHGA FOXA2 NKX6-1 NKX6-2 POU5F1 PTF1A
8 no phenotypic analysis MP:0003012 9.43 CHGA NEUROG3 NKX6-1 PTF1A SOX17 SOX2
9 normal MP:0002873 9.28 FOXA2 GHRL NEUROG3 NKX6-2 POU5F1 PTF1A

Drugs & Therapeutics for Non-Functioning Pancreatic Endocrine Tumor

Drugs for Non-Functioning Pancreatic Endocrine Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pancrelipase Approved, Investigational Phase 4 53608-75-6
2 pancreatin Phase 4
3 Fluorodeoxyglucose F18 Phase 4
4
Sirolimus Approved, Investigational Phase 3 53123-88-9 46835353 5284616 6436030
5
Everolimus Approved Phase 3 159351-69-6 70789204 6442177
6
Somatostatin Approved, Investigational Phase 3 38916-34-6, 51110-01-1 53481605
7 Immunologic Factors Phase 3,Phase 1
8 Immunosuppressive Agents Phase 3
9 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
10 Hormone Antagonists Phase 3
11 Hormones Phase 3
12
Temozolomide Approved, Investigational Phase 1 85622-93-1 5394
13
Lenograstim Approved, Investigational Phase 1 135968-09-1
14 Mitogens Phase 1
15 Alkylating Agents Phase 1
16 Adjuvants, Immunologic Phase 1
17 Antineoplastic Agents, Alkylating Phase 1
18 Antimetabolites Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Nonfunctional Pancreatic NET and PET Imaging Unknown status NCT02621541 Phase 4
2 Clinical Effectiveness of Serum Chromogranin A Levels on Diagnostic of Pancreatic Neuroendocrine Tumors Unknown status NCT02759718 Phase 4
3 Cabozantinib S-malate in Treating Patients With Neuroendocrine Tumors Previously Treated With Everolimus That Are Locally Advanced, Metastatic, or Cannot Be Removed by Surgery Recruiting NCT03375320 Phase 3 Cabozantinib S-malate
4 Non-functioning Pancreatic Neuroendocrine Tumors in MEN1: Somatostatin Analogs Versus NO Treatment Not yet recruiting NCT02705651 Phase 3 Somatostatin-Analog
5 Safety of TAS-102 in Combination With Temozolomide for Metastatic Pancreatic NETs Recruiting NCT02943733 Phase 1 TAS-102;Temozolomide;Filgrastim;Pegfilgrastim
6 Veliparib, Capecitabine, and Temozolomide in Patients With Advanced, Metastatic, and Recurrent Neuroendocrine Tumor Withdrawn NCT02831179 Phase 1 Capecitabine;Temozolomide;Veliparib
7 Diagnostic Accuracy of Preoperative Diagnostic Procedure in the Assessment of Lymph Node Metastases by NF-PanNENs Recruiting NCT03918759
8 Asymptomatic Small Pancreatic Endocrine Neoplasms. Recruiting NCT03084770

Search NIH Clinical Center for Non-Functioning Pancreatic Endocrine Tumor

Cochrane evidence based reviews: non functioning pancreatic endocrine tumor

Genetic Tests for Non-Functioning Pancreatic Endocrine Tumor

Anatomical Context for Non-Functioning Pancreatic Endocrine Tumor

MalaCards organs/tissues related to Non-Functioning Pancreatic Endocrine Tumor:

42
Lymph Node, Pancreas, Kidney, Ovary, Cervix

Publications for Non-Functioning Pancreatic Endocrine Tumor

Variations for Non-Functioning Pancreatic Endocrine Tumor

Expression for Non-Functioning Pancreatic Endocrine Tumor

Search GEO for disease gene expression data for Non-Functioning Pancreatic Endocrine Tumor.

Pathways for Non-Functioning Pancreatic Endocrine Tumor

GO Terms for Non-Functioning Pancreatic Endocrine Tumor

Cellular components related to Non-Functioning Pancreatic Endocrine Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription factor complex GO:0005667 9.13 PTF1A SOX17 SOX2
2 nuclear transcription factor complex GO:0044798 8.62 SOX17 SOX2

Biological processes related to Non-Functioning Pancreatic Endocrine Tumor according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription by RNA polymerase II GO:0000122 9.91 NEUROG3 NKX6-1 NKX6-2 POU5F1 SOX17 SOX2
2 positive regulation of transcription by RNA polymerase II GO:0045944 9.87 FOXA2 NEUROG3 NKX6-1 POU5F1 PTF1A SOX17
3 multicellular organism development GO:0007275 9.8 FOXA2 NEUROG3 NKX6-1 NKX6-2 POU5F1 PTF1A
4 regulation of transcription, DNA-templated GO:0006355 9.76 FOXA2 NEUROG3 NKX6-1 NKX6-2 POU5F1 PTF1A
5 positive regulation of cell differentiation GO:0045597 9.63 NEUROG3 SOX17 SOX2
6 oligodendrocyte differentiation GO:0048709 9.58 NKX6-1 NKX6-2
7 negative regulation of insulin secretion GO:0046676 9.57 CHGA GHRL
8 pancreas development GO:0031016 9.56 NKX6-1 PTF1A
9 hindbrain development GO:0030902 9.55 NEUROG3 PTF1A
10 mRNA transcription by RNA polymerase II GO:0042789 9.54 POU5F1 SOX17
11 transcription by RNA polymerase II GO:0006366 9.52 NKX6-1 POU5F1
12 positive regulation of glial cell differentiation GO:0045687 9.51 NKX6-1 NKX6-2
13 cell differentiation GO:0030154 9.5 FOXA2 NEUROG3 NKX6-1 NKX6-2 PTF1A SOX17
14 endodermal cell fate specification GO:0001714 9.49 POU5F1 SOX2
15 regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification GO:0021913 9.48 NKX6-1 NKX6-2
16 negative regulation of glial cell differentiation GO:0045686 9.4 NKX6-1 NKX6-2
17 regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification GO:0021912 9.37 NKX6-1 NKX6-2
18 endocrine pancreas development GO:0031018 8.92 FOXA2 NEUROG3 NKX6-1 NKX6-2

Molecular functions related to Non-Functioning Pancreatic Endocrine Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA binding GO:0003677 9.86 FOXA2 NEUROG3 NKX6-1 NKX6-2 POU5F1 PTF1A
2 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 9.76 FOXA2 NEUROG3 NKX6-1 NKX6-2 POU5F1 PTF1A
3 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.67 FOXA2 NEUROG3 NKX6-1 NKX6-2
4 hormone activity GO:0005179 9.5 GAST GHRL PPY
5 DNA-binding transcription factor activity GO:0003700 9.5 FOXA2 NEUROG3 NKX6-1 NKX6-2 POU5F1 SOX17
6 miRNA binding GO:0035198 9.4 POU5F1 SOX2
7 sequence-specific DNA binding GO:0043565 9.17 FOXA2 NKX6-1 NKX6-2 POU5F1 PTF1A SOX17

Sources for Non-Functioning Pancreatic Endocrine Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
Content
Loading form....