MCID: NNF008
MIFTS: 22

Non-Functioning Paraganglioma

Categories: Endocrine diseases, Rare diseases

Aliases & Classifications for Non-Functioning Paraganglioma

MalaCards integrated aliases for Non-Functioning Paraganglioma:

Name: Non-Functioning Paraganglioma 59
Non-Secreting Paraganglioma 59

Classifications:

Orphanet: 59  
Rare endocrine diseases


Summaries for Non-Functioning Paraganglioma

MalaCards based summary : Non-Functioning Paraganglioma, also known as non-secreting paraganglioma, is related to paraganglioma and aortic aneurysm, familial abdominal, 1. An important gene associated with Non-Functioning Paraganglioma is NKX2-1 (NK2 Homeobox 1). Affiliated tissues include heart, testes and liver, and related phenotypes are tremor and dysphonia

Related Diseases for Non-Functioning Paraganglioma

Diseases related to Non-Functioning Paraganglioma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 paraganglioma 10.4
2 aortic aneurysm, familial abdominal, 1 9.9
3 aortic aneurysm 9.9

Symptoms & Phenotypes for Non-Functioning Paraganglioma

Human phenotypes related to Non-Functioning Paraganglioma:

59 32 (show all 31)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 tremor 59 32 occasional (7.5%) Occasional (29-5%) HP:0001337
2 dysphonia 59 32 frequent (33%) Frequent (79-30%) HP:0001618
3 fatigue 59 32 frequent (33%) Frequent (79-30%) HP:0012378
4 pallor 59 32 occasional (7.5%) Occasional (29-5%) HP:0000980
5 weight loss 59 32 frequent (33%) Frequent (79-30%) HP:0001824
6 congestive heart failure 59 32 occasional (7.5%) Occasional (29-5%) HP:0001635
7 vocal cord paralysis 59 32 occasional (7.5%) Occasional (29-5%) HP:0001605
8 hematuria 59 32 occasional (7.5%) Occasional (29-5%) HP:0000790
9 conductive hearing impairment 59 32 occasional (7.5%) Occasional (29-5%) HP:0000405
10 chest pain 59 32 frequent (33%) Frequent (79-30%) HP:0100749
11 hypercalcemia 59 32 frequent (33%) Frequent (79-30%) HP:0003072
12 episodic abdominal pain 59 32 frequent (33%) Frequent (79-30%) HP:0002574
13 cerebral hemorrhage 59 32 frequent (33%) Frequent (79-30%) HP:0001342
14 sinus tachycardia 59 32 frequent (33%) Frequent (79-30%) HP:0011703
15 nausea 59 32 frequent (33%) Frequent (79-30%) HP:0002018
16 recurrent paroxysmal headache 59 32 frequent (33%) Frequent (79-30%) HP:0002331
17 flushing 59 32 frequent (33%) Frequent (79-30%) HP:0031284
18 palpitations 59 32 frequent (33%) Frequent (79-30%) HP:0001962
19 cranial nerve compression 59 32 occasional (7.5%) Occasional (29-5%) HP:0001293
20 episodic hyperhidrosis 59 32 frequent (33%) Frequent (79-30%) HP:0001069
21 hypertensive retinopathy 59 32 frequent (33%) Frequent (79-30%) HP:0001095
22 paraganglioma of head and neck 59 32 frequent (33%) Frequent (79-30%) HP:0002864
23 elevated urinary norepinephrine 59 32 frequent (33%) Frequent (79-30%) HP:0003345
24 positive regitine blocking test 59 32 frequent (33%) Frequent (79-30%) HP:0003574
25 elevated urinary epinephrine 59 32 frequent (33%) Frequent (79-30%) HP:0003639
26 pulsatile tinnitus 59 32 frequent (33%) Frequent (79-30%) HP:0008629
27 paroxysmal vertigo 59 32 frequent (33%) Frequent (79-30%) HP:0010532
28 elevated urinary dopamine 59 32 frequent (33%) Frequent (79-30%) HP:0011979
29 panic attack 59 32 occasional (7.5%) Occasional (29-5%) HP:0025269
30 paraganglioma 59 Very frequent (99-80%)
31 hypertension associated with pheochromocytoma 59 Frequent (79-30%)

Drugs & Therapeutics for Non-Functioning Paraganglioma

Search Clinical Trials , NIH Clinical Center for Non-Functioning Paraganglioma

Genetic Tests for Non-Functioning Paraganglioma

Anatomical Context for Non-Functioning Paraganglioma

MalaCards organs/tissues related to Non-Functioning Paraganglioma:

41
Heart, Testes, Liver

Publications for Non-Functioning Paraganglioma

Articles related to Non-Functioning Paraganglioma:

# Title Authors Year
1
Soft tissue metastasis of mediastinal non-functioning paraganglioma with unusual TTF-1 expression: a potential diagnostic pitfall. ( 29517207 )
2017
2
Retroperitoneal non-functioning paraganglioma: A difficult tumour to diagnose and treat. ( 26624503 )
2015
3
Non-functioning paraganglioma occurring in the urinary bladder: A case report and review of the literature. ( 26171023 )
2015
4
Non-functioning paraganglioma of the urinary bladder: A case report and review of the literature. ( 24520306 )
2014
5
Primary non-functioning paraganglioma of liver: a rare tumour at an unusual location. ( 22356009 )
2011
6
Extra-adrenal non-functioning paraganglioma. ( 2195728 )
1990
7
Non-functioning paraganglioma in wall of abdominal aortic aneurysm: a source of diagnostic confusion. ( 3320363 )
1987

Variations for Non-Functioning Paraganglioma

Expression for Non-Functioning Paraganglioma

Search GEO for disease gene expression data for Non-Functioning Paraganglioma.

Pathways for Non-Functioning Paraganglioma

GO Terms for Non-Functioning Paraganglioma

Sources for Non-Functioning Paraganglioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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