MCID: NNF008
MIFTS: 19

Non-Functioning Paraganglioma

Categories: Endocrine diseases, Rare diseases

Aliases & Classifications for Non-Functioning Paraganglioma

MalaCards integrated aliases for Non-Functioning Paraganglioma:

Name: Non-Functioning Paraganglioma 60
Non-Secreting Paraganglioma 60

Classifications:

Orphanet: 60  
Rare endocrine diseases


Summaries for Non-Functioning Paraganglioma

MalaCards based summary : Non-Functioning Paraganglioma, also known as non-secreting paraganglioma, is related to paraganglioma and aortic aneurysm, familial abdominal, 1. An important gene associated with Non-Functioning Paraganglioma is NKX2-1 (NK2 Homeobox 1). Affiliated tissues include testes, and related phenotypes are dysphonia and fatigue

Related Diseases for Non-Functioning Paraganglioma

Diseases related to Non-Functioning Paraganglioma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 paraganglioma 10.5
2 aortic aneurysm, familial abdominal, 1 9.9
3 aortic aneurysm 9.9

Symptoms & Phenotypes for Non-Functioning Paraganglioma

Human phenotypes related to Non-Functioning Paraganglioma:

60 33 (show all 31)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 dysphonia 60 33 frequent (33%) Frequent (79-30%) HP:0001618
2 fatigue 60 33 frequent (33%) Frequent (79-30%) HP:0012378
3 weight loss 60 33 frequent (33%) Frequent (79-30%) HP:0001824
4 chest pain 60 33 frequent (33%) Frequent (79-30%) HP:0100749
5 hypercalcemia 60 33 frequent (33%) Frequent (79-30%) HP:0003072
6 episodic abdominal pain 60 33 frequent (33%) Frequent (79-30%) HP:0002574
7 cerebral hemorrhage 60 33 frequent (33%) Frequent (79-30%) HP:0001342
8 nausea 60 33 frequent (33%) Frequent (79-30%) HP:0002018
9 episodic hyperhidrosis 60 33 frequent (33%) Frequent (79-30%) HP:0001069
10 sinus tachycardia 60 33 frequent (33%) Frequent (79-30%) HP:0011703
11 palpitations 60 33 frequent (33%) Frequent (79-30%) HP:0001962
12 recurrent paroxysmal headache 60 33 frequent (33%) Frequent (79-30%) HP:0002331
13 flushing 60 33 frequent (33%) Frequent (79-30%) HP:0031284
14 hypertensive retinopathy 60 33 frequent (33%) Frequent (79-30%) HP:0001095
15 paraganglioma of head and neck 60 33 frequent (33%) Frequent (79-30%) HP:0002864
16 elevated urinary norepinephrine 60 33 frequent (33%) Frequent (79-30%) HP:0003345
17 positive regitine blocking test 60 33 frequent (33%) Frequent (79-30%) HP:0003574
18 elevated urinary epinephrine 60 33 frequent (33%) Frequent (79-30%) HP:0003639
19 pulsatile tinnitus 60 33 frequent (33%) Frequent (79-30%) HP:0008629
20 paroxysmal vertigo 60 33 frequent (33%) Frequent (79-30%) HP:0010532
21 elevated urinary dopamine 60 33 frequent (33%) Frequent (79-30%) HP:0011979
22 tremor 60 33 occasional (7.5%) Occasional (29-5%) HP:0001337
23 pallor 60 33 occasional (7.5%) Occasional (29-5%) HP:0000980
24 congestive heart failure 60 33 occasional (7.5%) Occasional (29-5%) HP:0001635
25 vocal cord paralysis 60 33 occasional (7.5%) Occasional (29-5%) HP:0001605
26 hematuria 60 33 occasional (7.5%) Occasional (29-5%) HP:0000790
27 conductive hearing impairment 60 33 occasional (7.5%) Occasional (29-5%) HP:0000405
28 cranial nerve compression 60 33 occasional (7.5%) Occasional (29-5%) HP:0001293
29 panic attack 60 33 occasional (7.5%) Occasional (29-5%) HP:0025269
30 paraganglioma 60 Very frequent (99-80%)
31 hypertension associated with pheochromocytoma 60 Frequent (79-30%)

Drugs & Therapeutics for Non-Functioning Paraganglioma

Search Clinical Trials , NIH Clinical Center for Non-Functioning Paraganglioma

Genetic Tests for Non-Functioning Paraganglioma

Anatomical Context for Non-Functioning Paraganglioma

MalaCards organs/tissues related to Non-Functioning Paraganglioma:

42
Testes

Publications for Non-Functioning Paraganglioma

Articles related to Non-Functioning Paraganglioma:

# Title Authors Year
1
Soft tissue metastasis of mediastinal non-functioning paraganglioma with unusual TTF-1 expression: a potential diagnostic pitfall. ( 29517207 )
2017
2
Non-functioning paraganglioma occurring in the urinary bladder: A case report and review of the literature. ( 26171023 )
2015
3
Retroperitoneal non-functioning paraganglioma: A difficult tumour to diagnose and treat. ( 26624503 )
2015
4
Non-functioning paraganglioma of the urinary bladder: A case report and review of the literature. ( 24520306 )
2014
5
Primary non-functioning paraganglioma of liver: a rare tumour at an unusual location. ( 22356009 )
2011
6
Extra-adrenal non-functioning paraganglioma. ( 2195728 )
1990
7
Non-functioning paraganglioma in wall of abdominal aortic aneurysm: a source of diagnostic confusion. ( 3320363 )
1987

Variations for Non-Functioning Paraganglioma

Expression for Non-Functioning Paraganglioma

Search GEO for disease gene expression data for Non-Functioning Paraganglioma.

Pathways for Non-Functioning Paraganglioma

GO Terms for Non-Functioning Paraganglioma

Sources for Non-Functioning Paraganglioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
Content
Loading form....