MCID: NNF008
MIFTS: 20

Non-Functioning Paraganglioma

Categories: Endocrine diseases, Rare diseases

Aliases & Classifications for Non-Functioning Paraganglioma

MalaCards integrated aliases for Non-Functioning Paraganglioma:

Name: Non-Functioning Paraganglioma 58
Non-Secreting Paraganglioma 58

Classifications:

Orphanet: 58  
Rare endocrine diseases


Summaries for Non-Functioning Paraganglioma

MalaCards based summary : Non-Functioning Paraganglioma, also known as non-secreting paraganglioma, is related to paraganglioma and rare tumor. An important gene associated with Non-Functioning Paraganglioma is NKX2-1 (NK2 Homeobox 1). Affiliated tissues include heart and adrenal gland, and related phenotypes are dysphonia and fatigue

Related Diseases for Non-Functioning Paraganglioma

Diseases related to Non-Functioning Paraganglioma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 paraganglioma 10.4
2 rare tumor 10.0
3 aortic aneurysm, familial abdominal, 1 10.0
4 pheochromocytoma 10.0
5 adrenal gland pheochromocytoma 10.0
6 extra-adrenal pheochromocytoma 10.0
7 aortic aneurysm 10.0
8 nonsyndromic paraganglioma 10.0

Graphical network of the top 20 diseases related to Non-Functioning Paraganglioma:



Diseases related to Non-Functioning Paraganglioma

Symptoms & Phenotypes for Non-Functioning Paraganglioma

Human phenotypes related to Non-Functioning Paraganglioma:

58 31 (show all 31)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 dysphonia 58 31 frequent (33%) Frequent (79-30%) HP:0001618
2 fatigue 58 31 frequent (33%) Frequent (79-30%) HP:0012378
3 hypercalcemia 58 31 frequent (33%) Frequent (79-30%) HP:0003072
4 chest pain 58 31 frequent (33%) Frequent (79-30%) HP:0100749
5 weight loss 58 31 frequent (33%) Frequent (79-30%) HP:0001824
6 cerebral hemorrhage 58 31 frequent (33%) Frequent (79-30%) HP:0001342
7 sinus tachycardia 58 31 frequent (33%) Frequent (79-30%) HP:0011703
8 episodic abdominal pain 58 31 frequent (33%) Frequent (79-30%) HP:0002574
9 palpitations 58 31 frequent (33%) Frequent (79-30%) HP:0001962
10 recurrent paroxysmal headache 58 31 frequent (33%) Frequent (79-30%) HP:0002331
11 nausea 58 31 frequent (33%) Frequent (79-30%) HP:0002018
12 paroxysmal vertigo 58 31 frequent (33%) Frequent (79-30%) HP:0010532
13 episodic hyperhidrosis 58 31 frequent (33%) Frequent (79-30%) HP:0001069
14 hypertensive retinopathy 58 31 frequent (33%) Frequent (79-30%) HP:0001095
15 paraganglioma of head and neck 58 31 frequent (33%) Frequent (79-30%) HP:0002864
16 elevated urinary norepinephrine 58 31 frequent (33%) Frequent (79-30%) HP:0003345
17 positive regitine blocking test 58 31 frequent (33%) Frequent (79-30%) HP:0003574
18 elevated urinary epinephrine 58 31 frequent (33%) Frequent (79-30%) HP:0003639
19 pulsatile tinnitus 58 31 frequent (33%) Frequent (79-30%) HP:0008629
20 elevated urinary dopamine 58 31 frequent (33%) Frequent (79-30%) HP:0011979
21 flushing 58 31 frequent (33%) Frequent (79-30%) HP:0031284
22 tremor 58 31 occasional (7.5%) Occasional (29-5%) HP:0001337
23 congestive heart failure 58 31 occasional (7.5%) Occasional (29-5%) HP:0001635
24 pallor 58 31 occasional (7.5%) Occasional (29-5%) HP:0000980
25 vocal cord paralysis 58 31 occasional (7.5%) Occasional (29-5%) HP:0001605
26 hematuria 58 31 occasional (7.5%) Occasional (29-5%) HP:0000790
27 conductive hearing impairment 58 31 occasional (7.5%) Occasional (29-5%) HP:0000405
28 panic attack 58 31 occasional (7.5%) Occasional (29-5%) HP:0025269
29 cranial nerve compression 58 31 occasional (7.5%) Occasional (29-5%) HP:0001293
30 paraganglioma 58 Very frequent (99-80%)
31 hypertension associated with pheochromocytoma 58 Frequent (79-30%)

Drugs & Therapeutics for Non-Functioning Paraganglioma

Search Clinical Trials , NIH Clinical Center for Non-Functioning Paraganglioma

Genetic Tests for Non-Functioning Paraganglioma

Anatomical Context for Non-Functioning Paraganglioma

MalaCards organs/tissues related to Non-Functioning Paraganglioma:

40
Heart, Adrenal Gland

Publications for Non-Functioning Paraganglioma

Articles related to Non-Functioning Paraganglioma:

(show all 21)
# Title Authors PMID Year
1
Non Functioning Paraganglioma in the Urinary Bladder: a Case Report. 61
32149376 2020
2
Multifactorial aetiology for non-uremic calciphylaxis: a case report. 61
29915661 2018
3
Soft tissue metastasis of mediastinal non-functioning paraganglioma with unusual TTF-1 expression: a potential diagnostic pitfall. 61
29517207 2017
4
[Non-secreting paraganglioma retroperitoneal]. 61
28533842 2017
5
Non-functioning paraganglioma occurring in the urinary bladder: A case report and review of the literature. 61
26171023 2015
6
[Non secreting paraganglioma of Zuckerkandl organ]. 61
26097634 2015
7
Retroperitoneal non-functioning paraganglioma: A difficult tumour to diagnose and treat. 61
26624503 2015
8
Non-functioning paraganglioma of the urinary bladder: A case report and review of the literature. 61
24520306 2014
9
[Retroperitoneal non-secreting paraganglioma: a rare cause of high intestinal occlusion]. 61
25469205 2014
10
[A case of malignant paraganglioma presenting with skull metastases]. 61
22824577 2012
11
Primary non-functioning paraganglioma of liver: a rare tumour at an unusual location. 61
22356009 2011
12
Reversible cerebral vasoconstriction syndrome in two patients with a carotid glomus tumour. 61
20855372 2010
13
[Retroperitoneal non-secreting paraganglioma. Apropos of a case]. 61
17396092 2007
14
[Incomplete Carney's Triad and arterial hypertension in a young woman]. 61
16555728 2006
15
[Retroperitoneal paraganglioma incidentally detected by health examination: a case report]. 61
10934607 2000
16
[Retroperitoneal non-secreting paraganglioma]. 61
10209712 1999
17
[Paraganglioma of the organ of Zuckerkandl]. 61
7729225 1994
18
[131I]metaiodobenzylguanidine treatment of a malignant paraganglioma. 61
1823844 1991
19
Extra-adrenal non-functioning paraganglioma. 61
2195728 1990
20
Immunohistochemical study of chromogranin in 100 cases of pheochromocytoma, carotid body tumour, medullary thyroid carcinoma and carcinoid tumour. 61
3131955 1988
21
Non-functioning paraganglioma in wall of abdominal aortic aneurysm: a source of diagnostic confusion. 61
3320363 1987

Variations for Non-Functioning Paraganglioma

Expression for Non-Functioning Paraganglioma

Search GEO for disease gene expression data for Non-Functioning Paraganglioma.

Pathways for Non-Functioning Paraganglioma

GO Terms for Non-Functioning Paraganglioma

Sources for Non-Functioning Paraganglioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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