NFPA
MCID: NNF007
MIFTS: 43

Non-Functioning Pituitary Adenoma (NFPA)

Categories: Cancer diseases, Endocrine diseases, Rare diseases

Aliases & Classifications for Non-Functioning Pituitary Adenoma

MalaCards integrated aliases for Non-Functioning Pituitary Adenoma:

Name: Non-Functioning Pituitary Adenoma 59
Non-Functioning Pituitary Gland Neoplasm 73
Nfpa 59

Characteristics:

Orphanet epidemiological data:

59
non-functioning pituitary adenoma
Inheritance: Not applicable; Prevalence: 1-9/100000 (Worldwide),1-9/100000 (Finland),1-9/100000 (Sweden),6-9/10000 (Belgium),6-9/10000 (Switzerland),6-9/10000 (United Kingdom),6-9/10000 (Finland);

Classifications:

Orphanet: 59  
Rare endocrine diseases


Summaries for Non-Functioning Pituitary Adenoma

MalaCards based summary : Non-Functioning Pituitary Adenoma, also known as non-functioning pituitary gland neoplasm, is related to acromegaly and functioning pituitary adenoma. An important gene associated with Non-Functioning Pituitary Adenoma is SST (Somatostatin), and among its related pathways/superpathways are Endochondral Ossification and Growth hormone receptor signaling. Affiliated tissues include pituitary, lung and brain, and related phenotypes are ptosis and diplopia

Related Diseases for Non-Functioning Pituitary Adenoma

Diseases related to Non-Functioning Pituitary Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 98)
# Related Disease Score Top Affiliating Genes
1 acromegaly 30.2 GH1 GHR SST
2 functioning pituitary adenoma 30.1 GH1 GHR MUC1 PTPN3 S100B SST
3 pituitary tumors 30.1 GH1 SST
4 hyperprolactinemia 30.0 GH1 SST
5 chordoma 29.7 MUC1 S100B
6 pituitary adenoma 10.9
7 adenoma 10.9
8 eosinophilia-myalgia syndrome 10.2
9 pituitary apoplexy 10.2
10 tsh producing pituitary tumor 10.1 GH1 SST
11 pituitary adenoma 1, multiple types 10.1 GH1 SST
12 isolated growth hormone deficiency 10.1 GH1 GHR
13 hypopituitarism 10.1
14 growth hormone deficiency 10.1
15 mccune-albright syndrome 10.1 GH1 SST
16 fibrous dysplasia 10.1 GH1 SST
17 isolated growth hormone deficiency, type ib 10.1 GH1 GHR
18 occipital horn syndrome 10.1
19 pituitary-dependent cushing's disease 10.1 GHR SST
20 pituitary gland disease 10.1 GH1 SST
21 pancreatoblastoma 10.1 MUC1 SST
22 villous adenoma 10.1 MUC1 SST
23 laron syndrome 10.1 GH1 GHR
24 duodenal disease 10.1 MUC1 SST
25 pituitary adenoma, prolactin-secreting 10.1 GH1 SST
26 duodenum cancer 10.1 MUC1 SST
27 pituitary hormone deficiency, combined, 2 10.1 GH1 GHR
28 mixed ductal-endocrine carcinoma 10.0 MUC1 SST
29 dwarfism 10.0 GH1 GHR
30 hyperthyroidism 10.0 GH1 SST
31 merkel cell carcinoma 10.0 MUC1 SST
32 turner syndrome 10.0 GH1 GHR
33 ectopic cushing syndrome 10.0 S100B SST
34 hyperinsulinism 10.0 GH1 SST
35 traumatic brain injury 10.0 GH1 S100B
36 hyperpituitarism 10.0 GH1 GHR SST
37 isolated growth hormone deficiency, type ii 10.0 GH1 GHR SST
38 insulin-like growth factor i 10.0 GH1 GHR SST
39 autoimmune disease 10.0
40 thyroid carcinoma, familial medullary 10.0
41 prostate cancer 10.0
42 hypogonadotropic hypogonadism 10.0
43 conn's syndrome 10.0
44 thyroid cancer 10.0
45 hypogonadism 10.0
46 gangliocytoma 10.0
47 adenocarcinoma 10.0
48 craniopharyngioma 10.0
49 endophthalmitis 10.0
50 pituitary carcinoma 10.0

Graphical network of the top 20 diseases related to Non-Functioning Pituitary Adenoma:



Diseases related to Non-Functioning Pituitary Adenoma

Symptoms & Phenotypes for Non-Functioning Pituitary Adenoma

Human phenotypes related to Non-Functioning Pituitary Adenoma:

59 32 (show top 50) (show all 57)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 ptosis 59 32 occasional (7.5%) Occasional (29-5%) HP:0000508
2 diplopia 59 32 occasional (7.5%) Occasional (29-5%) HP:0000651
3 seizures 59 32 occasional (7.5%) Occasional (29-5%) HP:0001250
4 hypotension 59 32 frequent (33%) Frequent (79-30%) HP:0002615
5 blindness 59 32 occasional (7.5%) Occasional (29-5%) HP:0000618
6 vomiting 59 32 frequent (33%) Frequent (79-30%) HP:0002013
7 fatigue 59 32 frequent (33%) Frequent (79-30%) HP:0012378
8 pallor 59 32 frequent (33%) Frequent (79-30%) HP:0000980
9 progressive visual loss 59 32 frequent (33%) Frequent (79-30%) HP:0000529
10 increased circulating gonadotropin level 59 32 frequent (33%) Frequent (79-30%) HP:0000837
11 hypogonadotrophic hypogonadism 59 32 frequent (33%) Frequent (79-30%) HP:0000044
12 easy fatigability 59 32 frequent (33%) Frequent (79-30%) HP:0003388
13 male hypogonadism 59 32 frequent (33%) Frequent (79-30%) HP:0000026
14 vertigo 59 32 occasional (7.5%) Occasional (29-5%) HP:0002321
15 abnormality of the menstrual cycle 59 32 frequent (33%) Frequent (79-30%) HP:0000140
16 headache 59 32 frequent (33%) Frequent (79-30%) HP:0002315
17 panhypopituitarism 59 32 occasional (7.5%) Occasional (29-5%) HP:0000871
18 increased serum testosterone level 59 32 occasional (7.5%) Occasional (29-5%) HP:0030088
19 secondary growth hormone deficiency 59 32 frequent (33%) Frequent (79-30%) HP:0008240
20 impotence 59 32 frequent (33%) Frequent (79-30%) HP:0000802
21 decreased fertility in females 59 32 frequent (33%) Frequent (79-30%) HP:0000868
22 pituitary hypothyroidism 59 32 frequent (33%) Frequent (79-30%) HP:0008245
23 decreased fertility in males 59 32 frequent (33%) Frequent (79-30%) HP:0012041
24 female hypogonadism 59 32 frequent (33%) Frequent (79-30%) HP:0000134
25 adrenocorticotropin deficient adrenal insufficiency 59 32 frequent (33%) Frequent (79-30%) HP:0011735
26 adrenocorticotropic hormone deficiency 59 32 frequent (33%) Frequent (79-30%) HP:0011748
27 decreased circulating acth level 59 32 frequent (33%) Frequent (79-30%) HP:0002920
28 bitemporal hemianopia 59 32 occasional (7.5%) Occasional (29-5%) HP:0030521
29 oculomotor nerve palsy 59 32 occasional (7.5%) Occasional (29-5%) HP:0012246
30 prolactin deficiency 59 32 occasional (7.5%) Occasional (29-5%) HP:0008202
31 cranial nerve vi palsy 59 32 occasional (7.5%) Occasional (29-5%) HP:0006897
32 increased intraabdominal fat 59 32 frequent (33%) Frequent (79-30%) HP:0008993
33 decreased female libido 59 32 frequent (33%) Frequent (79-30%) HP:0030018
34 central diabetes insipidus 59 32 occasional (7.5%) Occasional (29-5%) HP:0000863
35 sudden loss of visual acuity 59 32 occasional (7.5%) Occasional (29-5%) HP:0001117
36 fourth cranial nerve palsy 59 32 occasional (7.5%) Occasional (29-5%) HP:0007011
37 internal ophthalmoplegia 59 32 occasional (7.5%) Occasional (29-5%) HP:0007942
38 abnormality of hair density 59 32 frequent (33%) Frequent (79-30%) HP:0011357
39 macroorchidism, postpubertal 59 32 occasional (7.5%) Occasional (29-5%) HP:0002050
40 anemia of inadequate production 59 32 frequent (33%) Frequent (79-30%) HP:0010972
41 nausea and vomiting 59 Frequent (79-30%)
42 macroorchidism 59 Occasional (29-5%)
43 cranial nerve paralysis 59 Occasional (29-5%)
44 anterior hypopituitarism 59 Frequent (79-30%)
45 hemianopsia 59 Occasional (29-5%)
46 hypogonadism 59 Frequent (79-30%)
47 diabetes insipidus 59 Occasional (29-5%)
48 erectile abnormalities 59 Frequent (79-30%)
49 adrenal insufficiency 59 Frequent (79-30%)
50 abnormality of the pituitary gland 59 Frequent (79-30%)

Drugs & Therapeutics for Non-Functioning Pituitary Adenoma

Search Clinical Trials , NIH Clinical Center for Non-Functioning Pituitary Adenoma

Genetic Tests for Non-Functioning Pituitary Adenoma

Anatomical Context for Non-Functioning Pituitary Adenoma

MalaCards organs/tissues related to Non-Functioning Pituitary Adenoma:

41
Pituitary, Lung, Brain, Prostate, Pancreas, Thyroid

Publications for Non-Functioning Pituitary Adenoma

Articles related to Non-Functioning Pituitary Adenoma:

(show top 50) (show all 60)
# Title Authors Year
1
EVALUATION OF CARDIOVASCULAR RISK WITH ARTERIAL STIFFNESS IN PATIENTS WITH NON-FUNCTIONING PITUITARY ADENOMA. ( 29975581 )
2018
2
Data of phosphoproteomic analysis of non-functioning pituitary adenoma. ( 29900237 )
2018
3
Mortality in patients with non-functioning pituitary adenoma. ( 29344906 )
2018
4
Genome-wide identification of lncRNAs and mRNAs differentially expressed in non-functioning pituitary adenoma and construction of a lncRNA-mRNA co-expression network. ( 30504132 )
2018
5
A two‑circRNA signature predicts tumour recurrence in clinical non‑functioning pituitary adenoma. ( 30542712 )
2018
6
Comorbidities in patients with non-functioning pituitary adenoma: influence of long-term growth hormone replacement ( 30299891 )
2018
7
Comorbidities in patients with non-functioning pituitary adenoma: influence of long-term growth hormone replacement. ( 30049813 )
2018
8
Incidence of malignant tumours in patients with a non-functioning pituitary adenoma. ( 28274953 )
2017
9
Non-functioning pituitary adenoma underwent surgery: A multicenter retrospective study over the last four decades (1977-2015). ( 28389053 )
2017
10
Time trends of mortality in patients with non-functioning pituitary adenoma: a Swedish nationwide study. ( 27743172 )
2016
11
Relationship of each anterior pituitary hormone deficiency to the size of non-functioning pituitary adenoma in the hospitalized patients. ( 27534814 )
2016
12
Higher Incidence of Morbidity in Women than Men with Non-functioning Pituitary Adenoma: a Swedish Nationwide Study. ( 27147638 )
2016
13
SNPs in the aryl hydrocarbon receptor-interacting protein gene associated with sporadic non-functioning pituitary adenoma. ( 26998050 )
2016
14
Clinical Concerns about Recurrence of Non-Functioning Pituitary Adenoma. ( 27195254 )
2016
15
Management of clinically non-functioning pituitary adenoma. ( 26072284 )
2015
16
Biological and radiological exploration and management of non-functioning pituitary adenoma. ( 26122495 )
2015
17
Post-surgical management of non-functioning pituitary adenoma. ( 26116412 )
2015
18
Neuro-ophthalmologic exploration in non-functioning pituitary adenoma. ( 26070465 )
2015
19
Brain abnormalities on MRI in non-functioning pituitary adenoma patients treated with or without postoperative radiotherapy. ( 25596913 )
2015
20
Non-functioning pituitary adenoma: when and how to operate? What pathologic criteria for typing? ( 26070464 )
2015
21
MORTALITY IN PATIENTS WITH NON-FUNCTIONING PITUITARY ADENOMA IS INCREASED: SYSTEMATIC ANALYSIS OF 546 CASES WITH LONG FOLLOW-UP. ( 26546611 )
2015
22
Candida albicans endophthalmitis in a patient with a non-functioning pituitary adenoma evolving into Cushingx^s disease: A case report. ( 25379398 )
2014
23
Analysis of short- and long-term metabolic effects of growth hormone replacement therapy in adult patients with craniopharyngioma and non-functioning pituitary adenoma. ( 25330765 )
2014
24
Cluster headache associated with a clinically non-functioning pituitary adenoma: a case report. ( 25526868 )
2014
25
Spontaneous regression of non-functioning pituitary adenoma due to pituitary apoplexy following anticoagulation treatment - a case report and review of the literature. ( 23450448 )
2013
26
Peptide receptor radionuclide therapy in a patient with disabling non-functioning pituitary adenoma. ( 23740146 )
2013
27
Intraoperative MRI and endocrinological outcome of transsphenoidal surgery for non-functioning pituitary adenoma. ( 22286656 )
2012
28
Combined gangliocytoma and non-functioning pituitary adenoma of the pituitary gland. ( 22824692 )
2012
29
Treatment with octreotide LAR in clinically non-functioning pituitary adenoma: results from a case-control study. ( 22207350 )
2012
30
Can we ever stop imaging in surgically treated and radiotherapy-naive patients with non-functioning pituitary adenoma? ( 21900406 )
2011
31
Non-functioning pituitary adenoma and concomitant Rathke's cleft cyst. ( 21934255 )
2011
32
Apoplexy in non functioning pituitary adenoma after one dose of leuprolide as treatment for prostate cancer. ( 19842040 )
2010
33
Metabolic, cardiovascular, and cerebrovascular outcomes in growth hormone-deficient subjects with previous cushing's disease or non-functioning pituitary adenoma. ( 20022992 )
2010
34
GH replacement in patients with non-functioning pituitary adenoma (NFA) treated solely by surgery is not associated with increased risk of tumour recurrence. ( 19236640 )
2009
35
Non-functioning pituitary adenoma: immunohistochemical analysis of 85 cases. ( 17594597 )
2007
36
Hypophysitis superimposed on a non-functioning pituitary adenoma: diagnostic clinical, endocrine, and radiologic features. ( 17923800 )
2007
37
Clinically non-functioning pituitary adenoma. ( 17082898 )
2006
38
Pituitary metastasis masquerading as non-functioning pituitary adenoma in a woman with adenocarcinoma lung. ( 16832588 )
2006
39
Frequent occurrence of pituitary apoplexy in patients with non-functioning pituitary adenoma. ( 16487443 )
2006
40
Non-functioning pituitary adenoma database: a useful resource to improve the clinical management of pituitary tumors. ( 17132751 )
2006
41
A non-functioning pituitary adenoma initially mimicking a microprolactinoma: The case for long-term follow-up of patients with mild hyperprolactinemia? ( 15966512 )
2005
42
[A case of a hemorrhagic non-functioning pituitary adenoma presenting with abducens nerve palsy]. ( 15912767 )
2005
43
SIADH closely associated with non-functioning pituitary adenoma. ( 15351800 )
2004
44
The diaphragma sellae meningioma -- a rare differential diagnosis of non-functioning pituitary adenoma. ( 15551185 )
2004
45
Idiopathic granulomatous hypophysitis presenting as non-functioning pituitary adenoma: description of six cases and review of literature. ( 15799151 )
2004
46
A case of non-functioning pituitary adenoma with Cushing's syndrome upon recurrence. ( 11837535 )
2001
47
Metamorphosis of a non-functioning pituitary adenoma to Cushing's disease. ( 12138984 )
2001
48
Long-term treatment with the dopamine agonist quinagolide of patients with clinically non-functioning pituitary adenoma. ( 11078985 )
2000
49
Spontaneous resolution of a non-functioning pituitary adenoma following an apoplexy. ( 11025642 )
2000
50
Metamorphosis of a non-functioning pituitary adenoma to Cushing's disease. ( 11141695 )
2000

Variations for Non-Functioning Pituitary Adenoma

Expression for Non-Functioning Pituitary Adenoma

Search GEO for disease gene expression data for Non-Functioning Pituitary Adenoma.

Pathways for Non-Functioning Pituitary Adenoma

Pathways related to Non-Functioning Pituitary Adenoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.77 GH1 GHR
2
Show member pathways
10.24 GH1 GHR

GO Terms for Non-Functioning Pituitary Adenoma

Cellular components related to Non-Functioning Pituitary Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.55 GH1 GHR MUC1 S100B SST
2 neuronal cell body GO:0043025 9.43 GHR S100B SST
3 extracellular space GO:0005615 9.35 GH1 GHR MUC1 S100B SST
4 growth hormone receptor complex GO:0070195 8.62 GH1 GHR

Biological processes related to Non-Functioning Pituitary Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.4 GH1 GHR
2 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.37 GH1 GHR
3 response to glucocorticoid GO:0051384 9.32 GHR S100B
4 positive regulation of multicellular organism growth GO:0040018 9.26 GH1 GHR
5 positive regulation of JAK-STAT cascade GO:0046427 9.16 GH1 GHR
6 JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 8.96 GH1 GHR
7 growth hormone receptor signaling pathway GO:0060396 8.62 GH1 GHR

Molecular functions related to Non-Functioning Pituitary Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.62 GH1 SST

Sources for Non-Functioning Pituitary Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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