NFPA
MCID: NNF007
MIFTS: 40

Non-Functioning Pituitary Adenoma (NFPA)

Categories: Cancer diseases, Endocrine diseases, Rare diseases

Aliases & Classifications for Non-Functioning Pituitary Adenoma

MalaCards integrated aliases for Non-Functioning Pituitary Adenoma:

Name: Non-Functioning Pituitary Adenoma 60 17
Non-Functioning Pituitary Gland Neoplasm 74
Nfpa 60

Characteristics:

Orphanet epidemiological data:

60
non-functioning pituitary adenoma
Inheritance: Not applicable; Prevalence: 1-9/100000 (Worldwide),1-9/100000 (Finland),1-9/100000 (Sweden),6-9/10000 (Belgium),6-9/10000 (Switzerland),6-9/10000 (United Kingdom),6-9/10000 (Finland);

Classifications:

Orphanet: 60  
Rare endocrine diseases


Summaries for Non-Functioning Pituitary Adenoma

MalaCards based summary : Non-Functioning Pituitary Adenoma, also known as non-functioning pituitary gland neoplasm, is related to acromegaly and pituitary tumors. An important gene associated with Non-Functioning Pituitary Adenoma is SST (Somatostatin), and among its related pathways/superpathways are Endochondral Ossification and Growth hormone receptor signaling. Affiliated tissues include pituitary, lung and brain, and related phenotypes are hypotension and vomiting

Related Diseases for Non-Functioning Pituitary Adenoma

Diseases related to Non-Functioning Pituitary Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 99)
# Related Disease Score Top Affiliating Genes
1 acromegaly 30.2 GH1 GHR SST
2 pituitary tumors 30.2 GH1 SST
3 hyperprolactinemia 30.1 GH1 SST
4 chordoma 29.5 MUC1 S100B
5 functioning pituitary adenoma 29.5 GH1 GHR MUC1 PTPN3 S100B SST
6 pituitary adenoma 10.9
7 adenoma 10.9
8 pituitary apoplexy 10.2
9 tsh producing pituitary tumor 10.2 GH1 SST
10 pituitary adenoma 1, multiple types 10.2 GH1 SST
11 isolated growth hormone deficiency 10.2 GH1 GHR
12 occipital horn syndrome 10.2
13 mccune-albright syndrome 10.1 GH1 SST
14 fibrous dysplasia 10.1 GH1 SST
15 isolated growth hormone deficiency, type ib 10.1 GH1 GHR
16 pituitary-dependent cushing's disease 10.1 GHR SST
17 pituitary gland disease 10.1 GH1 SST
18 hypopituitarism 10.1
19 growth hormone deficiency 10.1
20 headache 10.1
21 pancreatoblastoma 10.1 MUC1 SST
22 laron syndrome 10.1 GH1 GHR
23 villous adenoma 10.1 MUC1 SST
24 pituitary adenoma, prolactin-secreting 10.1 GH1 SST
25 duodenum cancer 10.1 MUC1 SST
26 pituitary hormone deficiency, combined, 2 10.1 GH1 GHR
27 mixed ductal-endocrine carcinoma 10.1 MUC1 SST
28 dwarfism 10.1 GH1 GHR
29 hyperthyroidism 10.0 GH1 SST
30 merkel cell carcinoma 10.0 MUC1 SST
31 turner syndrome 10.0 GH1 GHR
32 autoimmune disease 10.0
33 thyroid carcinoma, familial medullary 10.0
34 prostate cancer 10.0
35 prostate cancer, hereditary, 8 10.0
36 prostate cancer, hereditary, 6 10.0
37 hypogonadotropic hypogonadism 10.0
38 conn's syndrome 10.0
39 thyroid cancer 10.0
40 hypogonadism 10.0
41 gangliocytoma 10.0
42 adenocarcinoma 10.0
43 craniopharyngioma 10.0
44 endophthalmitis 10.0
45 pituitary carcinoma 10.0
46 diaphragma sellae meningioma 10.0
47 hypogonadotropism 10.0
48 cluster headache 10.0
49 granulomatous hypophysitis 10.0
50 hypoadrenalism 10.0

Graphical network of the top 20 diseases related to Non-Functioning Pituitary Adenoma:



Diseases related to Non-Functioning Pituitary Adenoma

Symptoms & Phenotypes for Non-Functioning Pituitary Adenoma

Human phenotypes related to Non-Functioning Pituitary Adenoma:

60 33 (show top 50) (show all 57)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 hypotension 60 33 frequent (33%) Frequent (79-30%) HP:0002615
2 vomiting 60 33 frequent (33%) Frequent (79-30%) HP:0002013
3 fatigue 60 33 frequent (33%) Frequent (79-30%) HP:0012378
4 pallor 60 33 frequent (33%) Frequent (79-30%) HP:0000980
5 progressive visual loss 60 33 frequent (33%) Frequent (79-30%) HP:0000529
6 increased circulating gonadotropin level 60 33 frequent (33%) Frequent (79-30%) HP:0000837
7 hypogonadotrophic hypogonadism 60 33 frequent (33%) Frequent (79-30%) HP:0000044
8 easy fatigability 60 33 frequent (33%) Frequent (79-30%) HP:0003388
9 male hypogonadism 60 33 frequent (33%) Frequent (79-30%) HP:0000026
10 abnormality of the menstrual cycle 60 33 frequent (33%) Frequent (79-30%) HP:0000140
11 headache 60 33 frequent (33%) Frequent (79-30%) HP:0002315
12 secondary growth hormone deficiency 60 33 frequent (33%) Frequent (79-30%) HP:0008240
13 impotence 60 33 frequent (33%) Frequent (79-30%) HP:0000802
14 decreased fertility in females 60 33 frequent (33%) Frequent (79-30%) HP:0000868
15 pituitary hypothyroidism 60 33 frequent (33%) Frequent (79-30%) HP:0008245
16 decreased fertility in males 60 33 frequent (33%) Frequent (79-30%) HP:0012041
17 female hypogonadism 60 33 frequent (33%) Frequent (79-30%) HP:0000134
18 adrenocorticotropin deficient adrenal insufficiency 60 33 frequent (33%) Frequent (79-30%) HP:0011735
19 adrenocorticotropic hormone deficiency 60 33 frequent (33%) Frequent (79-30%) HP:0011748
20 decreased circulating acth level 60 33 frequent (33%) Frequent (79-30%) HP:0002920
21 increased intraabdominal fat 60 33 frequent (33%) Frequent (79-30%) HP:0008993
22 decreased female libido 60 33 frequent (33%) Frequent (79-30%) HP:0030018
23 abnormality of hair density 60 33 frequent (33%) Frequent (79-30%) HP:0011357
24 anemia of inadequate production 60 33 frequent (33%) Frequent (79-30%) HP:0010972
25 ptosis 60 33 occasional (7.5%) Occasional (29-5%) HP:0000508
26 diplopia 60 33 occasional (7.5%) Occasional (29-5%) HP:0000651
27 seizures 60 33 occasional (7.5%) Occasional (29-5%) HP:0001250
28 blindness 60 33 occasional (7.5%) Occasional (29-5%) HP:0000618
29 vertigo 60 33 occasional (7.5%) Occasional (29-5%) HP:0002321
30 panhypopituitarism 60 33 occasional (7.5%) Occasional (29-5%) HP:0000871
31 increased serum testosterone level 60 33 occasional (7.5%) Occasional (29-5%) HP:0030088
32 bitemporal hemianopia 60 33 occasional (7.5%) Occasional (29-5%) HP:0030521
33 oculomotor nerve palsy 60 33 occasional (7.5%) Occasional (29-5%) HP:0012246
34 prolactin deficiency 60 33 occasional (7.5%) Occasional (29-5%) HP:0008202
35 cranial nerve vi palsy 60 33 occasional (7.5%) Occasional (29-5%) HP:0006897
36 central diabetes insipidus 60 33 occasional (7.5%) Occasional (29-5%) HP:0000863
37 sudden loss of visual acuity 60 33 occasional (7.5%) Occasional (29-5%) HP:0001117
38 fourth cranial nerve palsy 60 33 occasional (7.5%) Occasional (29-5%) HP:0007011
39 internal ophthalmoplegia 60 33 occasional (7.5%) Occasional (29-5%) HP:0007942
40 macroorchidism, postpubertal 60 33 occasional (7.5%) Occasional (29-5%) HP:0002050
41 nausea and vomiting 60 Frequent (79-30%)
42 macroorchidism 60 Occasional (29-5%)
43 cranial nerve paralysis 60 Occasional (29-5%)
44 anterior hypopituitarism 60 Frequent (79-30%)
45 hemianopsia 60 Occasional (29-5%)
46 hypogonadism 60 Frequent (79-30%)
47 diabetes insipidus 60 Occasional (29-5%)
48 erectile abnormalities 60 Frequent (79-30%)
49 adrenal insufficiency 60 Frequent (79-30%)
50 abnormality of the pituitary gland 60 Frequent (79-30%)

Drugs & Therapeutics for Non-Functioning Pituitary Adenoma

Search Clinical Trials , NIH Clinical Center for Non-Functioning Pituitary Adenoma

Genetic Tests for Non-Functioning Pituitary Adenoma

Anatomical Context for Non-Functioning Pituitary Adenoma

MalaCards organs/tissues related to Non-Functioning Pituitary Adenoma:

42
Pituitary, Lung, Brain, Prostate

Publications for Non-Functioning Pituitary Adenoma

Articles related to Non-Functioning Pituitary Adenoma:

(show top 50) (show all 62)
# Title Authors Year
1
Quality of Life but not Cognition is Impacted by Radiotherapy in Patients with Non-Functioning Pituitary Adenoma. ( 30861564 )
2019
2
Genome-wide identification of lncRNAs and mRNAs differentially expressed in non-functioning pituitary adenoma and construction of an lncRNA-mRNA co-expression network. ( 30504132 )
2019
3
A two‑circRNA signature predicts tumour recurrence in clinical non‑functioning pituitary adenoma. ( 30542712 )
2019
4
EVALUATION OF CARDIOVASCULAR RISK WITH ARTERIAL STIFFNESS IN PATIENTS WITH NON-FUNCTIONING PITUITARY ADENOMA. ( 29975581 )
2018
5
Data of phosphoproteomic analysis of non-functioning pituitary adenoma. ( 29900237 )
2018
6
Mortality in patients with non-functioning pituitary adenoma. ( 29344906 )
2018
7
Endocrinological outcomes of intraoperative MRI-guided endoscopic transsphenoidal surgery for non-functioning pituitary adenoma. ( 30649793 )
2018
8
Comorbidities in patients with non-functioning pituitary adenoma: influence of long-term growth hormone replacement ( 30299891 )
2018
9
Comorbidities in patients with non-functioning pituitary adenoma: influence of long-term growth hormone replacement. ( 30049813 )
2018
10
Incidence of malignant tumours in patients with a non-functioning pituitary adenoma. ( 28274953 )
2017
11
Non-functioning pituitary adenoma underwent surgery: A multicenter retrospective study over the last four decades (1977-2015). ( 28389053 )
2017
12
Time trends of mortality in patients with non-functioning pituitary adenoma: a Swedish nationwide study. ( 27743172 )
2016
13
Relationship of each anterior pituitary hormone deficiency to the size of non-functioning pituitary adenoma in the hospitalized patients. ( 27534814 )
2016
14
Higher Incidence of Morbidity in Women than Men with Non-functioning Pituitary Adenoma: a Swedish Nationwide Study. ( 27147638 )
2016
15
SNPs in the aryl hydrocarbon receptor-interacting protein gene associated with sporadic non-functioning pituitary adenoma. ( 26998050 )
2016
16
Clinical Concerns about Recurrence of Non-Functioning Pituitary Adenoma. ( 27195254 )
2016
17
Management of clinically non-functioning pituitary adenoma. ( 26072284 )
2015
18
Biological and radiological exploration and management of non-functioning pituitary adenoma. ( 26122495 )
2015
19
Post-surgical management of non-functioning pituitary adenoma. ( 26116412 )
2015
20
Neuro-ophthalmologic exploration in non-functioning pituitary adenoma. ( 26070465 )
2015
21
Brain abnormalities on MRI in non-functioning pituitary adenoma patients treated with or without postoperative radiotherapy. ( 25596913 )
2015
22
Non-functioning pituitary adenoma: when and how to operate? What pathologic criteria for typing? ( 26070464 )
2015
23
MORTALITY IN PATIENTS WITH NON-FUNCTIONING PITUITARY ADENOMA IS INCREASED: SYSTEMATIC ANALYSIS OF 546 CASES WITH LONG FOLLOW-UP. ( 26546611 )
2015
24
Candida albicans endophthalmitis in a patient with a non-functioning pituitary adenoma evolving into Cushingx^s disease: A case report. ( 25379398 )
2014
25
Analysis of short- and long-term metabolic effects of growth hormone replacement therapy in adult patients with craniopharyngioma and non-functioning pituitary adenoma. ( 25330765 )
2014
26
Cluster headache associated with a clinically non-functioning pituitary adenoma: a case report. ( 25526868 )
2014
27
Spontaneous regression of non-functioning pituitary adenoma due to pituitary apoplexy following anticoagulation treatment - a case report and review of the literature. ( 23450448 )
2013
28
Peptide receptor radionuclide therapy in a patient with disabling non-functioning pituitary adenoma. ( 23740146 )
2013
29
Intraoperative MRI and endocrinological outcome of transsphenoidal surgery for non-functioning pituitary adenoma. ( 22286656 )
2012
30
Combined gangliocytoma and non-functioning pituitary adenoma of the pituitary gland. ( 22824692 )
2012
31
Treatment with octreotide LAR in clinically non-functioning pituitary adenoma: results from a case-control study. ( 22207350 )
2012
32
Can we ever stop imaging in surgically treated and radiotherapy-naive patients with non-functioning pituitary adenoma? ( 21900406 )
2011
33
Non-functioning pituitary adenoma and concomitant Rathke's cleft cyst. ( 21934255 )
2011
34
Apoplexy in non functioning pituitary adenoma after one dose of leuprolide as treatment for prostate cancer. ( 19842040 )
2010
35
Metabolic, cardiovascular, and cerebrovascular outcomes in growth hormone-deficient subjects with previous cushing's disease or non-functioning pituitary adenoma. ( 20022992 )
2010
36
GH replacement in patients with non-functioning pituitary adenoma (NFA) treated solely by surgery is not associated with increased risk of tumour recurrence. ( 19236640 )
2009
37
Non-functioning pituitary adenoma: immunohistochemical analysis of 85 cases. ( 17594597 )
2007
38
Hypophysitis superimposed on a non-functioning pituitary adenoma: diagnostic clinical, endocrine, and radiologic features. ( 17923800 )
2007
39
Clinically non-functioning pituitary adenoma. ( 17082898 )
2006
40
Pituitary metastasis masquerading as non-functioning pituitary adenoma in a woman with adenocarcinoma lung. ( 16832588 )
2006
41
Frequent occurrence of pituitary apoplexy in patients with non-functioning pituitary adenoma. ( 16487443 )
2006
42
Non-functioning pituitary adenoma database: a useful resource to improve the clinical management of pituitary tumors. ( 17132751 )
2006
43
A non-functioning pituitary adenoma initially mimicking a microprolactinoma: The case for long-term follow-up of patients with mild hyperprolactinemia? ( 15966512 )
2005
44
[A case of a hemorrhagic non-functioning pituitary adenoma presenting with abducens nerve palsy]. ( 15912767 )
2005
45
SIADH closely associated with non-functioning pituitary adenoma. ( 15351800 )
2004
46
The diaphragma sellae meningioma -- a rare differential diagnosis of non-functioning pituitary adenoma. ( 15551185 )
2004
47
Idiopathic granulomatous hypophysitis presenting as non-functioning pituitary adenoma: description of six cases and review of literature. ( 15799151 )
2004
48
A case of non-functioning pituitary adenoma with Cushing's syndrome upon recurrence. ( 11837535 )
2001
49
Metamorphosis of a non-functioning pituitary adenoma to Cushing's disease. ( 12138984 )
2001
50
Long-term treatment with the dopamine agonist quinagolide of patients with clinically non-functioning pituitary adenoma. ( 11078985 )
2000

Variations for Non-Functioning Pituitary Adenoma

Expression for Non-Functioning Pituitary Adenoma

Search GEO for disease gene expression data for Non-Functioning Pituitary Adenoma.

Pathways for Non-Functioning Pituitary Adenoma

Pathways related to Non-Functioning Pituitary Adenoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.77 GH1 GHR
2
Show member pathways
10.24 GH1 GHR

GO Terms for Non-Functioning Pituitary Adenoma

Cellular components related to Non-Functioning Pituitary Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.55 GH1 GHR MUC1 S100B SST
2 neuronal cell body GO:0043025 9.43 GHR S100B SST
3 extracellular space GO:0005615 9.35 GH1 GHR MUC1 S100B SST
4 growth hormone receptor complex GO:0070195 8.62 GH1 GHR

Biological processes related to Non-Functioning Pituitary Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.4 GH1 GHR
2 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.37 GH1 GHR
3 response to glucocorticoid GO:0051384 9.32 GHR S100B
4 positive regulation of multicellular organism growth GO:0040018 9.26 GH1 GHR
5 positive regulation of JAK-STAT cascade GO:0046427 9.16 GH1 GHR
6 JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 8.96 GH1 GHR
7 growth hormone receptor signaling pathway GO:0060396 8.62 GH1 GHR

Molecular functions related to Non-Functioning Pituitary Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.62 GH1 SST

Sources for Non-Functioning Pituitary Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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