MCID: NNG001
MIFTS: 30

Non-Gestational Choriocarcinoma

Categories: Cancer diseases, Fetal diseases, Reproductive diseases

Aliases & Classifications for Non-Gestational Choriocarcinoma

MalaCards integrated aliases for Non-Gestational Choriocarcinoma:

Name: Non-Gestational Choriocarcinoma 12 15
Choriocarcinoma, Non-Gestational 44 73

Classifications:



External Ids:

Disease Ontology 12 DOID:4320
MeSH 44 D031954
UMLS 73 C1135873

Summaries for Non-Gestational Choriocarcinoma

Disease Ontology : 12 A choriocarcicoma that develops in the absence of a preceding gestational event.

MalaCards based summary : Non-Gestational Choriocarcinoma, also known as choriocarcinoma, non-gestational, is related to choriocarcinoma of ovary and primary non-gestational choriocarcinoma of ovary. An important gene associated with Non-Gestational Choriocarcinoma is CSH1 (Chorionic Somatomammotropin Hormone 1), and among its related pathways/superpathways are Pyruvate metabolism and Photodynamic therapy-induced HIF-1 survival signaling. Affiliated tissues include ovary, cervix and lung, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Non-Gestational Choriocarcinoma

Graphical network of the top 20 diseases related to Non-Gestational Choriocarcinoma:



Diseases related to Non-Gestational Choriocarcinoma

Symptoms & Phenotypes for Non-Gestational Choriocarcinoma

GenomeRNAi Phenotypes related to Non-Gestational Choriocarcinoma according to GeneCards Suite gene sharing:

26 (show all 11)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-145 9.47 LDHA
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-15 9.47 LDHA
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-179 9.47 LDHA
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.47 LDHA
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-184 9.47 ADAR IGFBP1 LDHA
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-203 9.47 ADAR LDHA
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-212 9.47 LDHA
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 9.47 ADAR
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-38 9.47 LDHA
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-59 9.47 LDHA
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.47 LDHA

Drugs & Therapeutics for Non-Gestational Choriocarcinoma

Search Clinical Trials , NIH Clinical Center for Non-Gestational Choriocarcinoma

Cochrane evidence based reviews: choriocarcinoma, non-gestational

Genetic Tests for Non-Gestational Choriocarcinoma

Anatomical Context for Non-Gestational Choriocarcinoma

MalaCards organs/tissues related to Non-Gestational Choriocarcinoma:

41
Ovary, Cervix, Lung, Small Intestine, Testis, Placenta

Publications for Non-Gestational Choriocarcinoma

Articles related to Non-Gestational Choriocarcinoma:

(show all 13)
# Title Authors Year
1
Non-Gestational Choriocarcinoma with Widespread Metastases Presenting with Type 1 Respiratory Failure in a 39-Year-Old Female: Case Report and Review of the Literature. ( 29681814 )
2018
2
Short tandem repeat analysis for confirmation of uterine non-gestational choriocarcinoma in a postmenopausal Taiwanese woman. ( 29465578 )
2018
3
Primary non-gestational choriocarcinoma of the uterine cervix with metaplastic transformation from adenocarcinoma: a case report. ( 28830246 )
2017
4
Pure non-gestational choriocarcinoma arising in the ovary. ( 29894083 )
2016
5
A case of non-gestational choriocarcinoma arising in the ovary of a postmenopausal woman. ( 19809555 )
2009
6
Primary non-gestational choriocarcinoma of the lung. ( 18097929 )
2007
7
Pure non-gestational choriocarcinoma of the ovary diagnosed by DNA polymorphism analysis. ( 16984618 )
2006
8
Primary non-gestational choriocarcinoma of the uterine cervix: a case report. ( 15925400 )
2005
9
Non-gestational choriocarcinoma in small intestine. ( 12546180 )
2002
10
Pure non-gestational choriocarcinoma of ovary a case report with autopsy findings. ( 12035382 )
2001
11
DNA polymorphism analysis of a pure non-gestational choriocarcinoma of the ovary: case report. ( 10843474 )
2000
12
A case of metastatic ovarian non-gestational choriocarcinoma: successful treatment with conservative type surgery and myeloablative chemotherapy. ( 10986872 )
2000
13
An extra gonadal non-gestational choriocarcinoma in a woman treated for an endometrial carcinoma. ( 7543866 )
1995

Variations for Non-Gestational Choriocarcinoma

Expression for Non-Gestational Choriocarcinoma

Search GEO for disease gene expression data for Non-Gestational Choriocarcinoma.

Pathways for Non-Gestational Choriocarcinoma

Pathways related to Non-Gestational Choriocarcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.88 LDHA LDHC
2 10.72 IGFBP1 LDHA
3 10.46 LDHA LDHC
4
Show member pathways
9.7 LDHA LDHC

GO Terms for Non-Gestational Choriocarcinoma

Biological processes related to Non-Gestational Choriocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.67 CSH1 CSH2 CSPG5 ENDOU
2 positive regulation of JAK-STAT cascade GO:0046427 9.4 CSH1 CSH2
3 pyruvate metabolic process GO:0006090 9.32 LDHA LDHC
4 carboxylic acid metabolic process GO:0019752 9.26 LDHA LDHC
5 animal organ development GO:0048513 9.16 CSH1 CSH2
6 growth hormone receptor signaling pathway GO:0060396 8.96 CSH1 CSH2
7 positive regulation of growth GO:0045927 8.62 CSH1 CSH2

Molecular functions related to Non-Gestational Choriocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0016616 9.26 LDHA LDHC
2 growth hormone receptor binding GO:0005131 9.16 CSH1 CSH2
3 L-lactate dehydrogenase activity GO:0004459 8.96 LDHA LDHC
4 growth factor activity GO:0008083 8.92 CSH1 CSH2 CSPG5 ENDOU

Sources for Non-Gestational Choriocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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