MCID: NNG001
MIFTS: 31

Non-Gestational Choriocarcinoma

Categories: Cancer diseases, Fetal diseases, Reproductive diseases

Aliases & Classifications for Non-Gestational Choriocarcinoma

MalaCards integrated aliases for Non-Gestational Choriocarcinoma:

Name: Non-Gestational Choriocarcinoma 12 15 17
Choriocarcinoma, Non-Gestational 45 74

Classifications:



External Ids:

Disease Ontology 12 DOID:4320
MeSH 45 D031954
UMLS 74 C1135873

Summaries for Non-Gestational Choriocarcinoma

Disease Ontology : 12 A choriocarcicoma that develops in the absence of a preceding gestational event.

MalaCards based summary : Non-Gestational Choriocarcinoma, also known as choriocarcinoma, non-gestational, is related to choriocarcinoma of ovary and endometrial cancer. An important gene associated with Non-Gestational Choriocarcinoma is CSH1 (Chorionic Somatomammotropin Hormone 1), and among its related pathways/superpathways are Pyruvate metabolism and Photodynamic therapy-induced HIF-1 survival signaling. Affiliated tissues include ovary, small intestine and cervix, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Non-Gestational Choriocarcinoma

Diseases related to Non-Gestational Choriocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 44)
# Related Disease Score Top Affiliating Genes
1 choriocarcinoma of ovary 30.4 CSH1 CSH2
2 endometrial cancer 29.6 BRCA2 IGFBP1 MSH6 PGR
3 primary non-gestational choriocarcinoma of ovary 12.5
4 non-gestational ovarian choriocarcinoma 11.6
5 gestational trophoblastic tumor 11.4
6 gestational choriocarcinoma 10.6
7 choriocarcinoma 10.6
8 oculogyric crisis 10.3 B2M GCH1
9 persistent fetal circulation syndrome 10.3 CSH1 IGFBP1
10 testicular trophoblastic tumor 10.2 CSH1 CSH2
11 small intestine lymphoma 10.2 B2M MSH6
12 adenoid basal cell carcinoma 10.2 B2M PGR
13 cecum adenocarcinoma 10.2 B2M MSH6
14 choriocarcinoma of the testis 10.2 CSH1 CSH2
15 gestational trophoblastic neoplasm 10.2 CSH1 CSH2
16 nosophobia 10.2 BRCA2 PGR
17 cancerophobia 10.2 BRCA2 PGR
18 chronic salpingitis 10.2 CSH1 CSH2
19 synchronous bilateral breast carcinoma 10.2 BRCA2 PGR
20 glycogen-rich clear cell breast carcinoma 10.2 BRCA2 PGR
21 lynch syndrome i 10.1 BRCA2 MSH6
22 bilateral breast cancer 10.1 BRCA2 PGR
23 primary peritoneal carcinoma 10.1 BRCA2 PGR
24 germ cell and embryonal cancer 10.1 CSH1 CSH2
25 pre-malignant neoplasm 10.1 BRCA2 PGR
26 fallopian tube carcinoma 10.1 BRCA2 PGR
27 respiratory failure 10.0
28 adenocarcinoma 10.0
29 dysgerminoma of ovary 10.0 BRCA2 PGR
30 coenurosis 10.0 LDHA LDHC
31 phototoxic dermatitis 10.0 LDHA LDHC
32 rh isoimmunization 10.0 CSH1 CSH2 MSH6
33 korean hemorrhagic fever 10.0 LDHA LDHC
34 dressler's syndrome 10.0 LDHA LDHC
35 breast abscess 10.0 LDHA LDHC
36 breast carcinoma in situ 10.0 BRCA2 PGR
37 hermansky-pudlak syndrome 5 10.0 LDHA LDHC
38 ovarian disease 10.0 BRCA2 IGFBP1 PGR
39 breast disease 10.0 BRCA2 IGFBP1 PGR
40 malignant ovarian surface epithelial-stromal neoplasm 10.0 BRCA2 PGR
41 ovary epithelial cancer 9.9 BRCA2 PGR
42 female breast cancer 9.8 BRCA2 PGR
43 uterine anomalies 9.8 CSH1 CSH2 MSH6 PGR
44 female reproductive system disease 9.5 BRCA2 CSH1 CSH2 MSH6 PGR

Graphical network of the top 20 diseases related to Non-Gestational Choriocarcinoma:



Diseases related to Non-Gestational Choriocarcinoma

Symptoms & Phenotypes for Non-Gestational Choriocarcinoma

GenomeRNAi Phenotypes related to Non-Gestational Choriocarcinoma according to GeneCards Suite gene sharing:

27 (show all 11)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-145 9.47 LDHA
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-15 9.47 LDHA
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-179 9.47 LDHA
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.47 LDHA
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-184 9.47 ADAR IGFBP1 LDHA
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-203 9.47 ADAR LDHA
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-212 9.47 LDHA
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 9.47 ADAR
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-38 9.47 LDHA
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-59 9.47 LDHA
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.47 LDHA

MGI Mouse Phenotypes related to Non-Gestational Choriocarcinoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.56 ADAR B2M BRCA2 ENDOU IGFBP1 LDHA
2 neoplasm MP:0002006 9.02 B2M BRCA2 LDHA MSH6 PGR

Drugs & Therapeutics for Non-Gestational Choriocarcinoma

Search Clinical Trials , NIH Clinical Center for Non-Gestational Choriocarcinoma

Cochrane evidence based reviews: choriocarcinoma, non-gestational

Genetic Tests for Non-Gestational Choriocarcinoma

Anatomical Context for Non-Gestational Choriocarcinoma

MalaCards organs/tissues related to Non-Gestational Choriocarcinoma:

42
Ovary, Small Intestine, Cervix, Testis

Publications for Non-Gestational Choriocarcinoma

Articles related to Non-Gestational Choriocarcinoma:

(show all 13)
# Title Authors Year
1
Non-Gestational Choriocarcinoma with Widespread Metastases Presenting with Type 1 Respiratory Failure in a 39-Year-Old Female: Case Report and Review of the Literature. ( 29681814 )
2018
2
Primary non-gestational choriocarcinoma of the uterine cervix with metaplastic transformation from adenocarcinoma: a case report. ( 28830246 )
2018
3
Short tandem repeat analysis for confirmation of uterine non-gestational choriocarcinoma in a postmenopausal Taiwanese woman. ( 29465578 )
2018
4
Pure non-gestational choriocarcinoma arising in the ovary. ( 29894083 )
2016
5
A case of non-gestational choriocarcinoma arising in the ovary of a postmenopausal woman. ( 19809555 )
2009
6
Primary non-gestational choriocarcinoma of the lung. ( 18097929 )
2007
7
Pure non-gestational choriocarcinoma of the ovary diagnosed by DNA polymorphism analysis. ( 16984618 )
2006
8
Primary non-gestational choriocarcinoma of the uterine cervix: a case report. ( 15925400 )
2005
9
Non-gestational choriocarcinoma in small intestine. ( 12546180 )
2002
10
Pure non-gestational choriocarcinoma of ovary a case report with autopsy findings. ( 12035382 )
2001
11
DNA polymorphism analysis of a pure non-gestational choriocarcinoma of the ovary: case report. ( 10843474 )
2000
12
A case of metastatic ovarian non-gestational choriocarcinoma: successful treatment with conservative type surgery and myeloablative chemotherapy. ( 10986872 )
2000
13
An extra gonadal non-gestational choriocarcinoma in a woman treated for an endometrial carcinoma. ( 7543866 )
1995

Variations for Non-Gestational Choriocarcinoma

Expression for Non-Gestational Choriocarcinoma

Search GEO for disease gene expression data for Non-Gestational Choriocarcinoma.

Pathways for Non-Gestational Choriocarcinoma

Pathways related to Non-Gestational Choriocarcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.88 LDHA LDHC
2 10.72 IGFBP1 LDHA
3 10.46 LDHA LDHC
4
Show member pathways
9.7 LDHA LDHC

GO Terms for Non-Gestational Choriocarcinoma

Biological processes related to Non-Gestational Choriocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.67 CSH1 CSH2 CSPG5 ENDOU
2 positive regulation of JAK-STAT cascade GO:0046427 9.4 CSH1 CSH2
3 pyruvate metabolic process GO:0006090 9.32 LDHA LDHC
4 carboxylic acid metabolic process GO:0019752 9.26 LDHA LDHC
5 animal organ development GO:0048513 9.16 CSH1 CSH2
6 mammary gland development GO:0030879 9.13 PGR
7 growth hormone receptor signaling pathway GO:0060396 8.96 CSH1 CSH2
8 positive regulation of growth GO:0045927 8.62 CSH1 CSH2

Molecular functions related to Non-Gestational Choriocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0016616 9.26 LDHA LDHC
2 growth hormone receptor binding GO:0005131 9.16 CSH1 CSH2
3 L-lactate dehydrogenase activity GO:0004459 8.96 LDHA LDHC
4 growth factor activity GO:0008083 8.92 CSH1 CSH2 CSPG5 ENDOU

Sources for Non-Gestational Choriocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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