MCID: NNG001
MIFTS: 26

Non-Gestational Choriocarcinoma

Categories: Cancer diseases, Fetal diseases, Reproductive diseases

Aliases & Classifications for Non-Gestational Choriocarcinoma

MalaCards integrated aliases for Non-Gestational Choriocarcinoma:

Name: Non-Gestational Choriocarcinoma 12 15 17
Choriocarcinoma, Non-Gestational 44 70

Classifications:



External Ids:

Disease Ontology 12 DOID:4320
MeSH 44 D031954
UMLS 70 C1135873

Summaries for Non-Gestational Choriocarcinoma

Disease Ontology : 12 A choriocarcicoma that develops in the absence of a preceding gestational event.

MalaCards based summary : Non-Gestational Choriocarcinoma, also known as choriocarcinoma, non-gestational, is related to gestational choriocarcinoma and choriocarcinoma of ovary. An important gene associated with Non-Gestational Choriocarcinoma is MIR302C (MicroRNA 302c). Affiliated tissues include ovary, placenta and uterus, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Non-Gestational Choriocarcinoma

Diseases related to Non-Gestational Choriocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 42)
# Related Disease Score Top Affiliating Genes
1 gestational choriocarcinoma 31.3 CSH2 CSH1
2 choriocarcinoma of ovary 30.5 SARNP CSH2 CSH1
3 gestational ovarian choriocarcinoma 30.0 CSH2 CSH1 AFP
4 primary non-gestational choriocarcinoma of ovary 11.3
5 choriocarcinoma 10.6
6 45,x/46,xy mixed gonadal dysgenesis 10.2 PRODH MIR302C
7 testicular trophoblastic tumor 10.2 CSH2 CSH1
8 supine hypotensive syndrome 10.2 CSH2 CSH1
9 placenta praevia 10.2 CSH2 CSH1
10 epithelioid trophoblastic tumor 10.2 CSH2 CSH1
11 rete ovarii adenoma 10.2 CSH2 CSH1
12 endometrial cancer 10.2
13 adenocarcinoma 10.2
14 ovarian germ cell teratoma 10.1 MIR302C AFP
15 rete ovarii benign neoplasm 10.1 CSH2 CSH1
16 juvenile type testicular granulosa cell tumor 10.1 MIR302C AFP
17 testicular granulosa cell tumor 10.1 MIR302C AFP
18 common bile duct disease 10.1 MIR302C AFP
19 placental site trophoblastic tumor 10.1 CSH2 CSH1
20 pediatric germ cell cancer 10.1 MIR302C AFP
21 cockayne syndrome b 10.1 CSH2 CSH1
22 ovarian germ cell cancer 10.1 MIR302C AFP
23 malignant teratoma 10.1 MIR302C AFP
24 mature teratoma 10.0 MIR302C AFP
25 persistent fetal circulation syndrome 10.0 CSH2 CSH1
26 sertoli-leydig cell tumor 10.0 MIR302C AFP
27 graft-versus-host disease 10.0
28 respiratory failure 10.0
29 hyperthyroidism 10.0
30 peritonitis 10.0
31 germ cells tumors 10.0
32 endodermal sinus tumor 10.0 PRODH MIR302C AFP
33 choriocarcinoma of the testis 10.0 CSH2 CSH1 AFP
34 non-gestational ovarian choriocarcinoma 10.0 CSH2 CSH1 AFP
35 dysgerminoma 10.0 MIR302C AFP
36 rh isoimmunization 10.0 CSH2 CSH1 AFP
37 trophoblastic neoplasm 10.0 CSH2 CSH1 AFP
38 gestational trophoblastic neoplasm 9.9 CSH2 CSH1 AFP
39 placenta disease 9.8 PRODH CSH2 CSH1 AFP
40 chromosomal duplication syndrome 9.8 PRODH AFP
41 pre-eclampsia 9.7 CSH2 CSH1 AFP
42 germ cell and embryonal cancer 9.7 PRODH MIR302C CSH2 CSH1 AFP

Graphical network of the top 20 diseases related to Non-Gestational Choriocarcinoma:



Diseases related to Non-Gestational Choriocarcinoma

Symptoms & Phenotypes for Non-Gestational Choriocarcinoma

GenomeRNAi Phenotypes related to Non-Gestational Choriocarcinoma according to GeneCards Suite gene sharing:

26 (show all 15)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-114 9.5 AFP
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-120 9.5 AFP
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-136 9.5 PRODH
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 9.5 PRODH
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-192 9.5 PRODH
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-198 9.5 PRODH
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-200 9.5 PRODH
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-29 9.5 AFP
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-4 9.5 PRODH
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-5 9.5 PRODH
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-55 9.5 PRODH
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-63 9.5 AFP
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-65 9.5 AFP
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-75 9.5 AFP
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-86 9.5 PRODH

Drugs & Therapeutics for Non-Gestational Choriocarcinoma

Search Clinical Trials , NIH Clinical Center for Non-Gestational Choriocarcinoma

Cochrane evidence based reviews: choriocarcinoma, non-gestational

Genetic Tests for Non-Gestational Choriocarcinoma

Anatomical Context for Non-Gestational Choriocarcinoma

MalaCards organs/tissues related to Non-Gestational Choriocarcinoma:

40
Ovary, Placenta, Uterus, Cervix, Small Intestine, Colon, Adrenal Gland

Publications for Non-Gestational Choriocarcinoma

Articles related to Non-Gestational Choriocarcinoma:

(show all 46)
# Title Authors PMID Year
1
A Rare Case of Non-Gestational Metastatic Ovarian Choriocarcinoma: Case Report and Literature Review With a Special Emphasis on Imaging. 61
33692915 2021
2
Imaging in gynecological disease: clinical and ultrasound characteristics of ovarian embryonal carcinomas, non-gestational choriocarcinomas and malignant mixed germ cell tumors. 61
33142349 2020
3
Extragonadal Non-gestational Choriocarcinoma with Tonsillar Presentation. 61
33128732 2020
4
Choriocarcinoma Presenting as a Pleural Effusion. 61
32923262 2020
5
Unusual abscess masquerading as poorly differentiated adenocarcinoma of the colon showing characteristics of choriocarcinoma. 61
33344291 2020
6
Widespread choriocarcinoma metastases from de-differentiated gastro-esophageal junction primary adenocarcinoma: A case report with literature review. 61
31886402 2020
7
[Endometrioid adenocarcinoma with a co-existing non-gestational choriocarcinoma in uterus]. 61
31791448 2019
8
[A case of misdiagnose of non-gestational choriocarcinoma metastasis to left atrium]. 61
31366001 2019
9
An unusual cause of gynaecomastia in a male 61
31373476 2019
10
Male primary mediastinal choriocarcinoma with diffuse metastases: A case report. 61
31305456 2019
11
Primary non-gestational uterine choriocarcinoma mimicking leiomyoma. 61
30775828 2019
12
A pilot study comparing the genetic molecular biology of gestational and non-gestational choriocarcinoma. 61
31814908 2019
13
Short tandem repeat analysis for confirmation of uterine non-gestational choriocarcinoma in a postmenopausal Taiwanese woman. 61
29465578 2018
14
Primary non-gestational choriocarcinoma of the uterine cervix with metaplastic transformation from adenocarcinoma: a case report. 61
28830246 2018
15
Non-Gestational Choriocarcinoma with Widespread Metastases Presenting with Type 1 Respiratory Failure in a 39-Year-Old Female: Case Report and Review of the Literature. 61
29681814 2018
16
[Pubertal ovarian non-gestational choriocarcinoma: report of a case]. 61
27760619 2016
17
Primary Gastric Chorioadenocarcinoma. 61
27602194 2016
18
Ovarian nongestational choriocarcinoma and associated adenocarcinoma with the same germ cell origin determined by a molecular genetic approach: A case report. 61
27484620 2016
19
Pure non-gestational choriocarcinoma arising in the ovary. 61
29894083 2016
20
A pure non-gestational ovarian choriocarcinoma with delayed solitary brain metastases: Case report and review of the literature. 61
26752905 2015
21
Primary non-gestational pure choriocarcinoma arising in the ovary: A case report and literature review. 61
26137022 2015
22
Choriocarcinoma of the adrenal gland: A case report. 61
25528034 2015
23
Fallopian tube choriocarcinoma presenting as ovarian tumour: a case report. 61
25738040 2015
24
Metastatic choriocarcinoma to the lumbar spine: Case report and review of literature. 61
25525554 2014
25
Intracranial choriocarcinoma occurrence in males: Two cases and a review of the literature. 61
24179518 2013
26
Primary ovary choriocarcinoma: individual DNA polymorphic analysis as a strategy to confirm diagnosis and treatment. 61
23888224 2013
27
Usefulness of intraoperative imprint cytology in ovarian germ cell tumors. 61
23406948 2013
28
[Genetic genesis of choriocarcinoma]. 61
20367924 2010
29
Molecular genetic analyses of choriocarcinoma. 61
19647314 2009
30
A case of non-gestational choriocarcinoma arising in the ovary of a postmenopausal woman. 61
19809555 2009
31
Primary non-gestational choriocarcinoma of the lung. 61
18097929 2007
32
Detection of non-maternal components of gestational choriocarcinoma by PCR-based microsatellite DNA assay. 61
16740299 2006
33
Pure non-gestational choriocarcinoma of the ovary diagnosed by DNA polymorphism analysis. 61
16984618 2006
34
Primary non-gestational choriocarcinoma of the uterine cervix: a case report. 61
15925400 2005
35
[Primary choriocarcinoma of the ovary: a case report]. 61
15450261 2004
36
Non-gestational choriocarcinoma in small intestine. 61
12546180 2002
37
Pure non-gestational choriocarcinoma of ovary a case report with autopsy findings. 61
12035382 2001
38
Choriocarcinoma of the gallbladder: treated with cisplatin-based chemotherapy. 61
11778764 2001
39
A case of metastatic ovarian non-gestational choriocarcinoma: successful treatment with conservative type surgery and myeloablative chemotherapy. 61
10986872 2000
40
DNA polymorphism analysis of a pure non-gestational choriocarcinoma of the ovary: case report. 61
10843474 2000
41
Coexistence of choriocarcinoma and adenocarcinoma in the rectum: molecular aspects. 61
8726837 1996
42
An extra gonadal non-gestational choriocarcinoma in a woman treated for an endometrial carcinoma. 61
7543866 1995
43
Ovarian neoplasms in children and adolescents in Papua New Guinea. 61
3453674 1987
44
[Reactivity of two monoclonal antibodies (Troma 1 and CAM 5.2) on tissue sections--as a histological trophoblast marker in normal pregnancy and trophoblastic disease]. 61
3009660 1986
45
[Studies on HLA-class I and class II antigen expression in cultured choriocarcinoma cell lines]. 61
3512743 1986
46
[A case with non-gestational choriocarcinoma of the uterus]. 61
4039345 1985

Variations for Non-Gestational Choriocarcinoma

Expression for Non-Gestational Choriocarcinoma

Search GEO for disease gene expression data for Non-Gestational Choriocarcinoma.

Pathways for Non-Gestational Choriocarcinoma

GO Terms for Non-Gestational Choriocarcinoma

Biological processes related to Non-Gestational Choriocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to nutrient levels GO:0031667 9.37 CSH2 CSH1
2 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.32 CSH2 CSH1
3 positive regulation of JAK-STAT cascade GO:0046427 9.26 CSH2 CSH1
4 animal organ development GO:0048513 9.16 CSH2 CSH1
5 growth hormone receptor signaling pathway GO:0060396 8.96 CSH2 CSH1
6 positive regulation of growth GO:0045927 8.62 CSH2 CSH1

Molecular functions related to Non-Gestational Choriocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.13 ENDOU CSH2 CSH1
2 growth hormone receptor binding GO:0005131 8.62 CSH2 CSH1

Sources for Non-Gestational Choriocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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