Non-Gestational Ovarian Choriocarcinoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Non-Gestational Ovarian Choriocarcinoma

MalaCards integrated aliases for Non-Gestational Ovarian Choriocarcinoma:

Name: Non-Gestational Ovarian Choriocarcinoma ¹² ¹⁵ ⁷⁰

Classifications:

MalaCards categories:
Global: Cancer diseases Fetal diseases
Anatomical: Endocrine diseases Reproductive diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:7665

NCIt ⁵⁰ C39991

UMLS ⁷⁰ C1518355

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Summaries for Non-Gestational Ovarian Choriocarcinoma

Disease Ontology : ¹² An ovarian primitive germ cell tumor that has material basis in trophoblastic cells and develops in the absence of a preceding gestational event.

MalaCards based summary : Non-Gestational Ovarian Choriocarcinoma is related to choriocarcinoma of ovary and gestational ovarian choriocarcinoma. An important gene associated with Non-Gestational Ovarian Choriocarcinoma is CSH1 (Chorionic Somatomammotropin Hormone 1), and among its related pathways/superpathways are PEDF Induced Signaling and Cytokine Signaling in Immune system. Affiliated tissues include ovary, placenta and breast.

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Related Diseases for Non-Gestational Ovarian Choriocarcinoma

Diseases related to Non-Gestational Ovarian Choriocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 84)

#	Related Disease	Score	Top Affiliating Genes
1	choriocarcinoma of ovary	31.2	CSH2 CSH1
2	gestational ovarian choriocarcinoma	30.5	CSH2 CSH1 CPSF4 AFP
3	gestational choriocarcinoma	30.3	TP53 CSH2 CSH1
4	non-gestational choriocarcinoma	30.2	CSH2 CSH1 AFP
5	ovarian cyst	30.1	PRL AFP
6	primary non-gestational choriocarcinoma of ovary	11.4
7	choriocarcinoma	10.6
8	germ cells tumors	10.3
9	testicular trophoblastic tumor	10.2	CSH2 CSH1
10	supine hypotensive syndrome	10.2	CSH2 CSH1
11	placenta praevia	10.2	CSH2 CSH1
12	epithelioid trophoblastic tumor	10.2	CSH2 CSH1
13	rete ovarii adenoma	10.2	CSH2 CSH1
14	rete ovarii benign neoplasm	10.2	CSH2 CSH1
15	placental site trophoblastic tumor	10.2	CSH2 CSH1
16	cockayne syndrome b	10.2	CSH2 CSH1
17	persistent fetal circulation syndrome	10.2	CSH2 CSH1
18	corpus luteum cyst	10.1	CPSF4 AFP
19	amenorrhea	10.1
20	germ cell cancer	10.1
21	adult teratoma	10.1	TP53 AFP
22	intratubular embryonal carcinoma	10.1	TP53 AFP
23	klatskin's tumor	10.1	TP53 AFP
24	liver benign neoplasm	10.1	TP53 AFP
25	mature teratoma	10.1	TP53 AFP
26	mixed cell type cancer	10.0	TP53 AFP
27	microinvasive gastric cancer	10.0	TP53 AFP
28	placenta accreta	10.0	TEK AFP
29	acinar cell carcinoma	10.0	TP53 AFP
30	ovarian gonadoblastoma	10.0	PRL AFP
31	obstructive hydrocephalus	10.0	PRL AFP
32	choriocarcinoma of the testis	10.0	CSH2 CSH1 AFP
33	rh isoimmunization	10.0	CSH2 CSH1 AFP
34	trophoblastic neoplasm	10.0	CSH2 CSH1 AFP
35	gestational trophoblastic neoplasm	10.0	CSH2 CSH1 AFP
36	placenta disease	10.0	CSH2 CSH1 AFP
37	granulosa cell tumor of the ovary	10.0	TP53 PRL
38	germinoma	10.0	PRL AFP
39	pituitary carcinoma	10.0	TP53 PRL
40	thoracic benign neoplasm	10.0	TP53 PRL
41	breast benign neoplasm	10.0	TP53 PRL
42	leydig cell tumor	9.9	PRL AFP
43	adult type testicular granulosa cell tumor	9.9	NCAM1 AFP
44	infected hydrocele	9.9	NCAM1 AFP
45	uterine benign neoplasm	9.9	TP53 PRL
46	esophageal adenoid cystic carcinoma	9.9	NCAM1 AFP
47	central nervous system benign neoplasm	9.9	TP53 PRL
48	endometrial small cell carcinoma	9.9	NCAM1 AFP
49	cardiovascular organ benign neoplasm	9.9	TP53 AFP
50	mediastinal cancer	9.9	NCAM1 AFP

Graphical network of the top 20 diseases related to Non-Gestational Ovarian Choriocarcinoma:

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Symptoms & Phenotypes for Non-Gestational Ovarian Choriocarcinoma

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Drugs & Therapeutics for Non-Gestational Ovarian Choriocarcinoma

Search Clinical Trials , NIH Clinical Center for Non-Gestational Ovarian Choriocarcinoma

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Genetic Tests for Non-Gestational Ovarian Choriocarcinoma

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Anatomical Context for Non-Gestational Ovarian Choriocarcinoma

MalaCards organs/tissues related to Non-Gestational Ovarian Choriocarcinoma:

⁴⁰

Ovary, Placenta, Breast, Liver, Lung, Adrenal Gland, Testis

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Publications for Non-Gestational Ovarian Choriocarcinoma

Articles related to Non-Gestational Ovarian Choriocarcinoma:

(show all 14)

#	Title	Authors	PMID	Year
1	A Rare Case of Non-Gestational Metastatic Ovarian Choriocarcinoma: Case Report and Literature Review With a Special Emphasis on Imaging. ⁶¹	Anjum AS...Fatima M	33692915	2021
2	Imaging in gynecological disease: clinical and ultrasound characteristics of ovarian embryonal carcinomas, non-gestational choriocarcinomas and malignant mixed germ cell tumors. ⁶¹	Moro F...Mascilini F	33142349	2020
3	Clinicopathological factors and prognosis analysis of 39 cases of non-gestational ovarian choriocarcinoma. ⁶¹	Liu X...Liu P	32185550	2020
4	Adolescent non-gestational ovarian choriocarcinoma: report of a case and review of literature. ⁶¹	Yang Y...Hao L	31933999	2019
5	Clinical and ultrasound features of non-gestational ovarian choriocarcinoma. ⁶¹	Mascilini F...Testa AC	29080278	2018
6	A positive urine pregnancy test (UPT) with adnexal mass; ectopic pregnancy is not the ultimate diagnosis. ⁶¹	Ahmad MF...Zakaria MA	29558344	2018
7	Extremely Rare Case of Bilateral Pure Primary Non-Gestational Ovarian Choriocarcinoma. ⁶¹	Syed M...Parida B	29657619	2017
8	Clinicopathological analysis of non-gestational ovarian choriocarcinoma: Report of two cases and review of the literature. ⁶¹	Wang Q...Liu A	27073524	2016
9	A pure non-gestational ovarian choriocarcinoma with delayed solitary brain metastases: Case report and review of the literature. ⁶¹	Rao KV...Sampath S	26752905	2015
10	[Clinical analysis of 15 cases of malignant ovarian germ cell tumors with lung metastasis]. ⁶¹	Liu Y...Xiang Y	22455692	2012
11	Pure non-gestational ovarian choriocarcinoma in a 45,XO/46,XX SRY-negative true hermaphrodite. ⁶¹	Hu T...Wang H	22070612	2011
12	Management of non-gestational ovarian choriocarcinoma: laparoscopy can be essential. Report of two cases. ⁶¹	Gremeau AS...Canis M	20561742	2010
13	Pure primary non-gestational ovarian choriocarcinoma: a diagnostic dilemma. ⁶¹	Gon S...Bhattacharya A	20090265	2010
14	Choriocarcinoma of the ovary in a post-menopausal woman. ⁶¹	Babu MK...Kini U	8979475	1996

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Genes for Non-Gestational Ovarian Choriocarcinoma

Genes related to Non-Gestational Ovarian Choriocarcinoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	CSH1	Chorionic Somatomammotropin Hormone 1	Protein Coding	6.18	DISEASES inferred ¹⁵
2	CSH2	Chorionic Somatomammotropin Hormone 2	Protein Coding	6.12	DISEASES inferred ¹⁵
3	CPSF4	Cleavage And Polyadenylation Specific Factor 4	Protein Coding	5.16	DISEASES inferred ¹⁵
4	AFP	Alpha Fetoprotein	Protein Coding	5.14	DISEASES inferred ¹⁵
5	TEK	TEK Receptor Tyrosine Kinase	Protein Coding	5.07	DISEASES inferred ¹⁵
6	PRL	Prolactin	Protein Coding	4.61	DISEASES inferred ¹⁵
7	NCAM1	Neural Cell Adhesion Molecule 1	Protein Coding	4.45	DISEASES inferred ¹⁵
8	TP53	Tumor Protein P53	Protein Coding	3.47	DISEASES inferred ¹⁵

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Variations for Non-Gestational Ovarian Choriocarcinoma

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Expression for Non-Gestational Ovarian Choriocarcinoma

Search GEO for disease gene expression data for Non-Gestational Ovarian Choriocarcinoma.

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Pathways for Non-Gestational Ovarian Choriocarcinoma

Pathways related to Non-Gestational Ovarian Choriocarcinoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	PEDF Induced Signaling ⁶³ Show member pathways all-trans-Retinoic Acid Signaling in Brain ⁶³ Cytokine-cytokine receptor interaction ³⁶ Endothelin-1 Signaling Pathway ⁶³ Glucocorticoid Receptor Signaling ⁶³ IL-6 Pathway ⁶³ MIF Mediated Glucocorticoid Regulation ⁶³ MIF Regulation of Innate Immune Cells ⁶³ NFAT Signaling and Lymphocyte Interactions ⁶³ PGC1Alpha Pathway ⁶³ RAR-Gamma-RXR-Alpha Degradation ⁶³ STAT3 Pathway ⁶³	13.14	TP53 TEK PRL CSH2 CSH1
2	Cytokine Signaling in Immune system ⁶⁵ Show member pathways Signaling by Interleukins ⁶⁵	12.66	TP53 TEK PRL NCAM1 CSH1
3	Prolactin Signaling Pathway ¹ ³⁶ Show member pathways Development Prolactin receptor signaling ²³ Leptin signaling pathway ¹	11.95	PRL CSH2 CSH1
4	PI3K-Akt signaling pathway ³⁶ Show member pathways Human papillomavirus infection ³⁶	11.86	TP53 TEK PRL CSH2 CSH1
5	JAK-STAT signaling pathway ³⁶ Show member pathways B-Cell Development ⁶³ IL-7 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types ⁶⁴ Interleukin-19, 20, 22, 24 ⁶⁵ Jak/STAT Signaling Pathway ⁶⁴ Type III interferon signaling ¹	11.83	PRL CSH2 CSH1
6	Glucocorticoid receptor regulatory network ¹	11.05	TP53 PRL AFP
7	Growth hormone receptor signaling ⁶⁵ Show member pathways Prolactin receptor signaling ⁶⁵	10.98	PRL CSH1

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GO Terms for Non-Gestational Ovarian Choriocarcinoma

Cellular components related to Non-Gestational Ovarian Choriocarcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:0005576	9.43	TEK PRL NCAM1 CSH2 CSH1 AFP
2	endosome lumen	GO:0031904	8.62	PRL CSH1

Biological processes related to Non-Gestational Ovarian Choriocarcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of pri-miRNA transcription by RNA polymerase II	GO:1902895	9.4	TP53 PRL
2	animal organ development	GO:0048513	9.37	CSH2 CSH1
3	JAK-STAT cascade involved in growth hormone signaling pathway	GO:0060397	9.32	PRL CSH1
4	growth hormone receptor signaling pathway	GO:0060396	9.26	CSH2 CSH1
5	positive regulation of growth	GO:0045927	9.16	CSH2 CSH1
6	response to nutrient levels	GO:0031667	9.13	PRL CSH2 CSH1
7	positive regulation of JAK-STAT cascade	GO:0046427	8.8	PRL CSH2 CSH1

Molecular functions related to Non-Gestational Ovarian Choriocarcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	hormone activity	GO:0005179	9.13	PRL CSH2 CSH1
2	growth hormone receptor binding	GO:0005131	8.62	CSH2 CSH1

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Sources for Non-Gestational Ovarian Choriocarcinoma

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GARD

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MedlinePlus Genetics

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 20-May-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ Tocris

⁷⁰ UMLS

⁷¹ UMLS via Orphanet

⁷² UniProtKB/Swiss-Prot

⁷³ Wikipedia