MCID: NNG002
MIFTS: 26

Non-Gestational Ovarian Choriocarcinoma

Categories: Cancer diseases, Endocrine diseases, Fetal diseases, Reproductive diseases

Aliases & Classifications for Non-Gestational Ovarian Choriocarcinoma

MalaCards integrated aliases for Non-Gestational Ovarian Choriocarcinoma:

Name: Non-Gestational Ovarian Choriocarcinoma 12 15 70

Classifications:



External Ids:

Disease Ontology 12 DOID:7665
NCIt 50 C39991
UMLS 70 C1518355

Summaries for Non-Gestational Ovarian Choriocarcinoma

Disease Ontology : 12 An ovarian primitive germ cell tumor that has material basis in trophoblastic cells and develops in the absence of a preceding gestational event.

MalaCards based summary : Non-Gestational Ovarian Choriocarcinoma is related to choriocarcinoma of ovary and gestational ovarian choriocarcinoma. An important gene associated with Non-Gestational Ovarian Choriocarcinoma is CSH1 (Chorionic Somatomammotropin Hormone 1), and among its related pathways/superpathways are PEDF Induced Signaling and Cytokine Signaling in Immune system. Affiliated tissues include ovary, placenta and breast.

Related Diseases for Non-Gestational Ovarian Choriocarcinoma

Diseases related to Non-Gestational Ovarian Choriocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 84)
# Related Disease Score Top Affiliating Genes
1 choriocarcinoma of ovary 31.2 CSH2 CSH1
2 gestational ovarian choriocarcinoma 30.5 CSH2 CSH1 CPSF4 AFP
3 gestational choriocarcinoma 30.3 TP53 CSH2 CSH1
4 non-gestational choriocarcinoma 30.2 CSH2 CSH1 AFP
5 ovarian cyst 30.1 PRL AFP
6 primary non-gestational choriocarcinoma of ovary 11.4
7 choriocarcinoma 10.6
8 germ cells tumors 10.3
9 testicular trophoblastic tumor 10.2 CSH2 CSH1
10 supine hypotensive syndrome 10.2 CSH2 CSH1
11 placenta praevia 10.2 CSH2 CSH1
12 epithelioid trophoblastic tumor 10.2 CSH2 CSH1
13 rete ovarii adenoma 10.2 CSH2 CSH1
14 rete ovarii benign neoplasm 10.2 CSH2 CSH1
15 placental site trophoblastic tumor 10.2 CSH2 CSH1
16 cockayne syndrome b 10.2 CSH2 CSH1
17 persistent fetal circulation syndrome 10.2 CSH2 CSH1
18 corpus luteum cyst 10.1 CPSF4 AFP
19 amenorrhea 10.1
20 germ cell cancer 10.1
21 adult teratoma 10.1 TP53 AFP
22 intratubular embryonal carcinoma 10.1 TP53 AFP
23 klatskin's tumor 10.1 TP53 AFP
24 liver benign neoplasm 10.1 TP53 AFP
25 mature teratoma 10.1 TP53 AFP
26 mixed cell type cancer 10.0 TP53 AFP
27 microinvasive gastric cancer 10.0 TP53 AFP
28 placenta accreta 10.0 TEK AFP
29 acinar cell carcinoma 10.0 TP53 AFP
30 ovarian gonadoblastoma 10.0 PRL AFP
31 obstructive hydrocephalus 10.0 PRL AFP
32 choriocarcinoma of the testis 10.0 CSH2 CSH1 AFP
33 rh isoimmunization 10.0 CSH2 CSH1 AFP
34 trophoblastic neoplasm 10.0 CSH2 CSH1 AFP
35 gestational trophoblastic neoplasm 10.0 CSH2 CSH1 AFP
36 placenta disease 10.0 CSH2 CSH1 AFP
37 granulosa cell tumor of the ovary 10.0 TP53 PRL
38 germinoma 10.0 PRL AFP
39 pituitary carcinoma 10.0 TP53 PRL
40 thoracic benign neoplasm 10.0 TP53 PRL
41 breast benign neoplasm 10.0 TP53 PRL
42 leydig cell tumor 9.9 PRL AFP
43 adult type testicular granulosa cell tumor 9.9 NCAM1 AFP
44 infected hydrocele 9.9 NCAM1 AFP
45 uterine benign neoplasm 9.9 TP53 PRL
46 esophageal adenoid cystic carcinoma 9.9 NCAM1 AFP
47 central nervous system benign neoplasm 9.9 TP53 PRL
48 endometrial small cell carcinoma 9.9 NCAM1 AFP
49 cardiovascular organ benign neoplasm 9.9 TP53 AFP
50 mediastinal cancer 9.9 NCAM1 AFP

Graphical network of the top 20 diseases related to Non-Gestational Ovarian Choriocarcinoma:



Diseases related to Non-Gestational Ovarian Choriocarcinoma

Symptoms & Phenotypes for Non-Gestational Ovarian Choriocarcinoma

Drugs & Therapeutics for Non-Gestational Ovarian Choriocarcinoma

Search Clinical Trials , NIH Clinical Center for Non-Gestational Ovarian Choriocarcinoma

Genetic Tests for Non-Gestational Ovarian Choriocarcinoma

Anatomical Context for Non-Gestational Ovarian Choriocarcinoma

MalaCards organs/tissues related to Non-Gestational Ovarian Choriocarcinoma:

40
Ovary, Placenta, Breast, Liver, Lung, Adrenal Gland, Testis

Publications for Non-Gestational Ovarian Choriocarcinoma

Articles related to Non-Gestational Ovarian Choriocarcinoma:

(show all 14)
# Title Authors PMID Year
1
A Rare Case of Non-Gestational Metastatic Ovarian Choriocarcinoma: Case Report and Literature Review With a Special Emphasis on Imaging. 61
33692915 2021
2
Imaging in gynecological disease: clinical and ultrasound characteristics of ovarian embryonal carcinomas, non-gestational choriocarcinomas and malignant mixed germ cell tumors. 61
33142349 2020
3
Clinicopathological factors and prognosis analysis of 39 cases of non-gestational ovarian choriocarcinoma. 61
32185550 2020
4
Adolescent non-gestational ovarian choriocarcinoma: report of a case and review of literature. 61
31933999 2019
5
Clinical and ultrasound features of non-gestational ovarian choriocarcinoma. 61
29080278 2018
6
A positive urine pregnancy test (UPT) with adnexal mass; ectopic pregnancy is not the ultimate diagnosis. 61
29558344 2018
7
Extremely Rare Case of Bilateral Pure Primary Non-Gestational Ovarian Choriocarcinoma. 61
29657619 2017
8
Clinicopathological analysis of non-gestational ovarian choriocarcinoma: Report of two cases and review of the literature. 61
27073524 2016
9
A pure non-gestational ovarian choriocarcinoma with delayed solitary brain metastases: Case report and review of the literature. 61
26752905 2015
10
[Clinical analysis of 15 cases of malignant ovarian germ cell tumors with lung metastasis]. 61
22455692 2012
11
Pure non-gestational ovarian choriocarcinoma in a 45,XO/46,XX SRY-negative true hermaphrodite. 61
22070612 2011
12
Management of non-gestational ovarian choriocarcinoma: laparoscopy can be essential. Report of two cases. 61
20561742 2010
13
Pure primary non-gestational ovarian choriocarcinoma: a diagnostic dilemma. 61
20090265 2010
14
Choriocarcinoma of the ovary in a post-menopausal woman. 61
8979475 1996

Variations for Non-Gestational Ovarian Choriocarcinoma

Expression for Non-Gestational Ovarian Choriocarcinoma

Search GEO for disease gene expression data for Non-Gestational Ovarian Choriocarcinoma.

Pathways for Non-Gestational Ovarian Choriocarcinoma

Pathways related to Non-Gestational Ovarian Choriocarcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.14 TP53 TEK PRL CSH2 CSH1
2
Show member pathways
12.66 TP53 TEK PRL NCAM1 CSH1
3
Show member pathways
11.95 PRL CSH2 CSH1
4
Show member pathways
11.86 TP53 TEK PRL CSH2 CSH1
5
Show member pathways
11.83 PRL CSH2 CSH1
6 11.05 TP53 PRL AFP
7
Show member pathways
10.98 PRL CSH1

GO Terms for Non-Gestational Ovarian Choriocarcinoma

Cellular components related to Non-Gestational Ovarian Choriocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.43 TEK PRL NCAM1 CSH2 CSH1 AFP
2 endosome lumen GO:0031904 8.62 PRL CSH1

Biological processes related to Non-Gestational Ovarian Choriocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.4 TP53 PRL
2 animal organ development GO:0048513 9.37 CSH2 CSH1
3 JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 9.32 PRL CSH1
4 growth hormone receptor signaling pathway GO:0060396 9.26 CSH2 CSH1
5 positive regulation of growth GO:0045927 9.16 CSH2 CSH1
6 response to nutrient levels GO:0031667 9.13 PRL CSH2 CSH1
7 positive regulation of JAK-STAT cascade GO:0046427 8.8 PRL CSH2 CSH1

Molecular functions related to Non-Gestational Ovarian Choriocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.13 PRL CSH2 CSH1
2 growth hormone receptor binding GO:0005131 8.62 CSH2 CSH1

Sources for Non-Gestational Ovarian Choriocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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