Non-Gestational Ovarian Choriocarcinoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Non-Gestational Ovarian Choriocarcinoma

MalaCards integrated aliases for Non-Gestational Ovarian Choriocarcinoma:

Name: Non-Gestational Ovarian Choriocarcinoma ¹² ¹⁵ ⁷⁴

Classifications:

MalaCards categories:
Global: Cancer diseases Fetal diseases
Anatomical: Endocrine diseases Reproductive diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:7665

NCIt ⁵¹ C39991

UMLS ⁷⁴ C1518355

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Summaries for Non-Gestational Ovarian Choriocarcinoma

Disease Ontology : ¹² An ovarian primitive germ cell tumor that has material basis in trophoblastic cells and develops in the absence of a preceding gestational event.

MalaCards based summary : Non-Gestational Ovarian Choriocarcinoma is related to primary non-gestational choriocarcinoma of ovary and choriocarcinoma. An important gene associated with Non-Gestational Ovarian Choriocarcinoma is TEK (TEK Receptor Tyrosine Kinase), and among its related pathways/superpathways are Innate Immune System and PI3K-Akt signaling pathway. Affiliated tissues include brain, and related phenotype is nervous system.

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Related Diseases for Non-Gestational Ovarian Choriocarcinoma

Diseases related to Non-Gestational Ovarian Choriocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 33)

#	Related Disease	Score	Top Affiliating Genes
1	primary non-gestational choriocarcinoma of ovary	11.9
2	choriocarcinoma	10.6
3	gestational ovarian choriocarcinoma	10.6
4	prolactin producing pituitary tumor	10.0	PRL TP53
5	granulosa cell tumor of the ovary	10.0	PRL TP53
6	chromophobe adenoma	10.0	PRL TP53
7	adenoma	10.0	PRL TP53
8	cell type benign neoplasm	10.0	PRL TP53
9	female reproductive system disease	9.9	PRL TP53
10	reproductive system disease	9.9	PRL TP53
11	gonadal disease	9.9	PRL TP53
12	ovarian disease	9.9	PRL TP53
13	cervix small cell carcinoma	9.9	NCAM1 TP53
14	small cell carcinoma	9.9	NCAM1 TP53
15	malignant mesenchymoma	9.9	NCAM1 TP53
16	hydrocephalus	9.9	PRL TP53
17	mature b-cell neoplasm	9.9	NCAM1 TP53
18	lung benign neoplasm	9.9	NCAM1 TP53
19	autonomic nervous system neoplasm	9.9	NCAM1 TP53
20	peripheral nervous system neoplasm	9.9	NCAM1 TP53
21	merkel cell carcinoma	9.8	NCAM1 TP53
22	leukocyte disease	9.8	NCAM1 TP53
23	adrenal rest tumor	9.8	NCAM1 PRL
24	bile duct cancer	9.8	NCAM1 TP53
25	small cell cancer of the lung	9.8	NCAM1 TP53
26	gastrointestinal stromal tumor	9.8	NCAM1 TP53
27	myeloma, multiple	9.7	NCAM1 TP53
28	diamond-blackfan anemia	9.7	PRL TP53
29	breast disease	9.7	PRL TEK TP53
30	muscular disease	9.7	NCAM1 TP53
31	cholangiocarcinoma	9.7	NCAM1 TP53
32	choriocarcinoma of ovary	9.5	NCAM1 PRL TEK
33	hematologic cancer	9.5	NCAM1 TP53

Graphical network of the top 20 diseases related to Non-Gestational Ovarian Choriocarcinoma:

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Symptoms & Phenotypes for Non-Gestational Ovarian Choriocarcinoma

MGI Mouse Phenotypes related to Non-Gestational Ovarian Choriocarcinoma:

⁴⁷

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	nervous system	MP:0003631	8.92	NCAM1 PRL TEK TP53

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Drugs & Therapeutics for Non-Gestational Ovarian Choriocarcinoma

Search Clinical Trials , NIH Clinical Center for Non-Gestational Ovarian Choriocarcinoma

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Genetic Tests for Non-Gestational Ovarian Choriocarcinoma

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Anatomical Context for Non-Gestational Ovarian Choriocarcinoma

MalaCards organs/tissues related to Non-Gestational Ovarian Choriocarcinoma:

⁴²

Brain

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Publications for Non-Gestational Ovarian Choriocarcinoma

Articles related to Non-Gestational Ovarian Choriocarcinoma:

#	Title	Authors	Year
1	Extremely Rare Case of Bilateral Pure Primary Non-Gestational Ovarian Choriocarcinoma. ( 29657619 )	Syed M....Parida B.	2017
2	Clinical and ultrasound features of non-gestational ovarian choriocarcinoma. ( 29080278 )	Mascilini F....Testa A.C.	2017
3	Clinicopathological analysis of non-gestational ovarian choriocarcinoma: Report of two cases and review of the literature. ( 27073524 )	Wang Q....Liu A.	2016
4	A pure non-gestational ovarian choriocarcinoma with delayed solitary brain metastases: Case report and review of the literature. ( 26752905 )	Rao K.V....Sampath S.	2015
5	Pure non-gestational ovarian choriocarcinoma in a 45,XO/46,XX SRY-negative true hermaphrodite. ( 22070612 )	Hu T....Wang H.	2011
6	Pure primary non-gestational ovarian choriocarcinoma: a diagnostic dilemma. ( 20090265 )	Gon S....Bhattacharya A.	2010
7	Management of non-gestational ovarian choriocarcinoma: laparoscopy can be essential. Report of two cases. ( 20561742 )	Gremeau A.S....Canis M.	2010

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Genes for Non-Gestational Ovarian Choriocarcinoma

Genes related to Non-Gestational Ovarian Choriocarcinoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	TEK	TEK Receptor Tyrosine Kinase	Protein Coding	15.13	DISEASES inferred ¹⁵
2	PRL	Prolactin	Protein Coding	14.18	DISEASES inferred ¹⁵
3	NCAM1	Neural Cell Adhesion Molecule 1	Protein Coding	14.16	DISEASES inferred ¹⁵
4	TP53	Tumor Protein P53	Protein Coding	12.98	DISEASES inferred ¹⁵

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Variations for Non-Gestational Ovarian Choriocarcinoma

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Expression for Non-Gestational Ovarian Choriocarcinoma

Search GEO for disease gene expression data for Non-Gestational Ovarian Choriocarcinoma.

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Pathways for Non-Gestational Ovarian Choriocarcinoma

Pathways related to Non-Gestational Ovarian Choriocarcinoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁷ Show member pathways Immune System ⁶⁷ Neutrophil degranulation ⁶⁷	13.22	NCAM1 PRL TEK TP53
2	PI3K-Akt signaling pathway ³⁸ Show member pathways Human papillomavirus infection ³⁸	12.17	PRL TEK TP53
3	Cytokine Signaling in Immune system ⁶⁷ Show member pathways Signaling by Interleukins ⁶⁷	12.03	NCAM1 PRL TEK TP53
4	AKT Signaling Pathway ⁶⁸	11.41	TEK TP53
5	Glucocorticoid receptor regulatory network ¹	10.87	PRL TP53

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GO Terms for Non-Gestational Ovarian Choriocarcinoma

Biological processes related to Non-Gestational Ovarian Choriocarcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	MAPK cascade	GO:0000165	9.16	NCAM1 TEK
2	negative regulation of angiogenesis	GO:0016525	8.96	PRL TEK
3	positive regulation of pri-miRNA transcription by RNA polymerase II	GO:1902895	8.62	PRL TP53

Molecular functions related to Non-Gestational Ovarian Choriocarcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	Ras guanyl-nucleotide exchange factor activity	GO:0005088	8.62	NCAM1 TEK

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Sources for Non-Gestational Ovarian Choriocarcinoma

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