MCID: NNH011
MIFTS: 14

Non-Hereditary Retinoblastoma

Categories: Eye diseases, Rare diseases

Aliases & Classifications for Non-Hereditary Retinoblastoma

MalaCards integrated aliases for Non-Hereditary Retinoblastoma:

Name: Non-Hereditary Retinoblastoma 59

Characteristics:

Orphanet epidemiological data:

59
non-hereditary retinoblastoma
Inheritance: Not applicable; Age of onset: Infancy,Neonatal; Age of death: any age;

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases
Orphanet: 59  
Rare eye diseases


External Ids:

Orphanet 59 ORPHA357034
ICD10 via Orphanet 34 C69.2

Summaries for Non-Hereditary Retinoblastoma

MalaCards based summary : Non-Hereditary Retinoblastoma is related to familial retinoblastoma and retinoblastoma. An important gene associated with Non-Hereditary Retinoblastoma is RB1 (RB Transcriptional Corepressor 1). Affiliated tissues include retina and eye, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Non-Hereditary Retinoblastoma

Diseases related to Non-Hereditary Retinoblastoma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 familial retinoblastoma 28.9 MYCN RB1
2 retinoblastoma 9.8
3 bilateral retinoblastoma 9.5 MYCN RB1
4 nervous system cancer 9.3 MYCN RB1
5 small cell cancer of the lung 9.2 MYCN RB1
6 glioblastoma 9.0 MYCN RB1

Graphical network of the top 20 diseases related to Non-Hereditary Retinoblastoma:



Diseases related to Non-Hereditary Retinoblastoma

Symptoms & Phenotypes for Non-Hereditary Retinoblastoma

GenomeRNAi Phenotypes related to Non-Hereditary Retinoblastoma according to GeneCards Suite gene sharing:

26 (show all 11)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.4 RB1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.4 MYCN
3 Increased shRNA abundance (Z-score > 2) GR00366-A-121 9.4 RB1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-138 9.4 MYCN
5 Increased shRNA abundance (Z-score > 2) GR00366-A-147 9.4 RB1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-172 9.4 RB1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.4 MYCN RB1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-210 9.4 RB1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.4 RB1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.4 RB1
11 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.4 RB1

Drugs & Therapeutics for Non-Hereditary Retinoblastoma

Search Clinical Trials , NIH Clinical Center for Non-Hereditary Retinoblastoma

Genetic Tests for Non-Hereditary Retinoblastoma

Anatomical Context for Non-Hereditary Retinoblastoma

MalaCards organs/tissues related to Non-Hereditary Retinoblastoma:

41
Retina, Eye

Publications for Non-Hereditary Retinoblastoma

Articles related to Non-Hereditary Retinoblastoma:

# Title Authors Year
1
Spectrum of germline mutations in the RB1 gene: a study of 232 patients with hereditary and non hereditary retinoblastoma. ( 7795591 )
1995

Variations for Non-Hereditary Retinoblastoma

Expression for Non-Hereditary Retinoblastoma

Search GEO for disease gene expression data for Non-Hereditary Retinoblastoma.

Pathways for Non-Hereditary Retinoblastoma

GO Terms for Non-Hereditary Retinoblastoma

Cellular components related to Non-Hereditary Retinoblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chromatin GO:0000785 8.62 MYCN RB1

Biological processes related to Non-Hereditary Retinoblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 8.96 MYCN RB1
2 negative regulation of gene expression GO:0010629 8.62 MYCN RB1

Molecular functions related to Non-Hereditary Retinoblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 kinase binding GO:0019900 8.62 MYCN RB1

Sources for Non-Hereditary Retinoblastoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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