MCID: NNH013
MIFTS: 21

Non-Histaminic Angioedema

Categories: Bone diseases, Immune diseases, Rare diseases

Aliases & Classifications for Non-Histaminic Angioedema

MalaCards integrated aliases for Non-Histaminic Angioedema:

Name: Non-Histaminic Angioedema 58
Non Histamine-Induced Angioedema 58
Bradykinine-Induced Angioedema 58
Angioneurotic Edema 58

Characteristics:

Orphanet epidemiological data:

58
non-histaminic angioedema
Inheritance: Autosomal dominant,Not applicable; Age of onset: All ages; Age of death: normal life expectancy;

Classifications:

Orphanet: 58  
Rare systemic and rhumatological diseases
Rare allergic disease


Summaries for Non-Histaminic Angioedema

MalaCards based summary : Non-Histaminic Angioedema, also known as non histamine-induced angioedema, is related to angioedema, hereditary, type i and hereditary angioedema. The drugs Icatibant and Bradykinin have been mentioned in the context of this disorder. Related phenotypes are angioedema and nausea and vomiting

Related Diseases for Non-Histaminic Angioedema

Diseases related to Non-Histaminic Angioedema via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 90)
# Related Disease Score Top Affiliating Genes
1 angioedema, hereditary, type i 11.7
2 hereditary angioedema 11.7
3 angioedema, hereditary, type iii 11.6
4 angioedema induced by ace inhibitors 11.4
5 hereditary angioedema with c1inh deficiency 11.3
6 hereditary angioedema with normal c1inh 11.3
7 acquired angioedema with c1inh deficiency 11.3
8 angioedema 11.3
9 acquired angioedema type 1 11.2
10 acquired angioedema type 2 11.2
11 urticaria 10.6
12 c1 inhibitor deficiency 10.4
13 complement component 4, partial deficiency of 10.3
14 chronic urticaria 10.3
15 systemic lupus erythematosus 10.2
16 exanthem 10.2
17 kearns-sayre syndrome 10.2
18 glomerulonephritis 10.2
19 lupus erythematosus 10.2
20 ige responsiveness, atopic 10.1
21 erythema multiforme 10.1
22 disseminated intravascular coagulation 10.1
23 conjunctivitis 10.1
24 crohn's disease 10.1
25 granulocytopenia 10.1
26 coproporphyria, hereditary 9.9
27 intussusception 9.9
28 cyclic neutropenia 9.9
29 vitiligo-associated multiple autoimmune disease susceptibility 6 9.9
30 celiac disease 1 9.9
31 myxedema 9.9
32 helicobacter pylori infection 9.9
33 vitiligo-associated multiple autoimmune disease susceptibility 1 9.9
34 nasopharyngeal carcinoma 9.9
35 severe cutaneous adverse reaction 9.9
36 alpha-1-antitrypsin deficiency 9.9
37 hydrops, lactic acidosis, and sideroblastic anemia 9.9
38 hereditary lymphedema 9.9
39 hemorrhagic cystitis 9.9
40 pain agnosia 9.9
41 crohn's colitis 9.9
42 lymphoproliferative syndrome 9.9
43 hereditary lymphedema i 9.9
44 chronic spontaneous urticaria 9.9
45 charcot-marie-tooth disease 9.9
46 tooth disease 9.9
47 erysipelas 9.9
48 nephrotic syndrome 9.9
49 allergic disease 9.9
50 neutropenia 9.9

Graphical network of the top 20 diseases related to Non-Histaminic Angioedema:



Diseases related to Non-Histaminic Angioedema

Symptoms & Phenotypes for Non-Histaminic Angioedema

Human phenotypes related to Non-Histaminic Angioedema:

31 (show all 15)
# Description HPO Frequency HPO Source Accession
1 angioedema 31 hallmark (90%) HP:0100665
2 nausea and vomiting 31 frequent (33%) HP:0002017
3 pruritus 31 frequent (33%) HP:0000989
4 diarrhea 31 frequent (33%) HP:0002014
5 pedal edema 31 frequent (33%) HP:0010741
6 pulmonary edema 31 frequent (33%) HP:0100598
7 muscle weakness 31 occasional (7.5%) HP:0001324
8 ascites 31 occasional (7.5%) HP:0001541
9 palpebral edema 31 occasional (7.5%) HP:0100540
10 glomerulopathy 31 occasional (7.5%) HP:0100820
11 peripheral neuropathy 31 occasional (7.5%) HP:0009830
12 skin rash 31 occasional (7.5%) HP:0000988
13 lymphoproliferative disorder 31 occasional (7.5%) HP:0005523
14 ovarian cyst 31 occasional (7.5%) HP:0000138
15 abnormal lymphocyte morphology 31 occasional (7.5%) HP:0004332

Drugs & Therapeutics for Non-Histaminic Angioedema

Drugs for Non-Histaminic Angioedema (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Icatibant Approved, Investigational Phase 1 130308-48-4, 138614-30-9 71364
2
Bradykinin Investigational Phase 1 58-82-2 439201
3 Analgesics, Non-Narcotic Phase 1
4 Complement System Proteins Phase 1
5 Angiotensin-Converting Enzyme Inhibitors Phase 1
6 Kininogens Phase 1
7 Analgesics Phase 1
8 Immunosuppressive Agents Phase 1
9 Antirheumatic Agents Phase 1
10 Immunologic Factors Phase 1
11 Anti-Inflammatory Agents Phase 1
12 Bradykinin Receptor Antagonists Phase 1
13 Anti-Inflammatory Agents, Non-Steroidal Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study of a Bradykinin Receptor Blocker in Angiotensin Converting Enzyme Inhibitor-Associated Angioedema Terminated NCT00517582 Phase 1 HOE-140

Search NIH Clinical Center for Non-Histaminic Angioedema

Genetic Tests for Non-Histaminic Angioedema

Anatomical Context for Non-Histaminic Angioedema

Publications for Non-Histaminic Angioedema

Articles related to Non-Histaminic Angioedema:

# Title Authors PMID Year
1
Hereditary angioedema: a current state-of-the-art review, II: historical perspective of non-histamine-induced angioedema. 61
18220145 2008

Variations for Non-Histaminic Angioedema

Expression for Non-Histaminic Angioedema

Search GEO for disease gene expression data for Non-Histaminic Angioedema.

Pathways for Non-Histaminic Angioedema

GO Terms for Non-Histaminic Angioedema

Sources for Non-Histaminic Angioedema

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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