MCID: NNH013
MIFTS: 29

Non-Histaminic Angioedema

Categories: Bone diseases, Immune diseases, Rare diseases

Aliases & Classifications for Non-Histaminic Angioedema

MalaCards integrated aliases for Non-Histaminic Angioedema:

Name: Non-Histaminic Angioedema 58
Non Histamine-Induced Angioedema 58
Bradykinine-Induced Angioedema 58
Angioneurotic Edema 58

Characteristics:

Orphanet epidemiological data:

58
non-histaminic angioedema
Inheritance: Autosomal dominant,Not applicable; Age of onset: All ages; Age of death: normal life expectancy;

Classifications:

Orphanet: 58  
Rare systemic and rhumatological diseases
Rare allergic disease


Summaries for Non-Histaminic Angioedema

MalaCards based summary : Non-Histaminic Angioedema, also known as non histamine-induced angioedema, is related to angioedema, hereditary, type i and hereditary angioedema. An important gene associated with Non-Histaminic Angioedema is F12 (Coagulation Factor XII). The drugs Azithromycin and Esomeprazole have been mentioned in the context of this disorder. Affiliated tissues include bone, lung and skin, and related phenotypes are angioedema and pruritus

Related Diseases for Non-Histaminic Angioedema

Diseases related to Non-Histaminic Angioedema via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 92)
# Related Disease Score Top Affiliating Genes
1 angioedema, hereditary, type i 12.2
2 hereditary angioedema 12.2
3 angioedema induced by ace inhibitors 12.0
4 angioedema 11.8
5 angioedema, hereditary, type iii 11.8
6 hereditary angioedema with c1inh deficiency 11.6
7 hereditary angioedema with normal c1inh 11.6
8 acquired angioedema with c1inh deficiency 11.6
9 acquired angioedema type 1 11.4
10 acquired angioedema type 2 11.4
11 urticaria 10.7
12 c1 inhibitor deficiency 10.4
13 complement component 4, partial deficiency of 10.4
14 lupus erythematosus 10.4
15 systemic lupus erythematosus 10.3
16 exanthem 10.3
17 autoimmune disease 10.2
18 kearns-sayre syndrome 10.2
19 allergic hypersensitivity disease 10.2
20 glomerulonephritis 10.2
21 ige responsiveness, atopic 10.2
22 erythema multiforme 10.2
23 disseminated intravascular coagulation 10.2
24 conjunctivitis 10.2
25 crohn's disease 10.2
26 granulocytopenia 10.2
27 coproporphyria, hereditary 10.0
28 intussusception 10.0
29 cyclic neutropenia 10.0
30 vitiligo-associated multiple autoimmune disease susceptibility 6 10.0
31 celiac disease 1 10.0
32 myxedema 10.0
33 helicobacter pylori infection 10.0
34 stroke, ischemic 10.0
35 vitiligo-associated multiple autoimmune disease susceptibility 1 10.0
36 nasopharyngeal carcinoma 10.0
37 severe cutaneous adverse reaction 10.0
38 alpha-1-antitrypsin deficiency 10.0
39 hydrops, lactic acidosis, and sideroblastic anemia 10.0
40 hereditary lymphedema 10.0
41 hemorrhagic cystitis 10.0
42 pain agnosia 10.0
43 crohn's colitis 10.0
44 lymphoproliferative syndrome 10.0
45 hereditary lymphedema i 10.0
46 charcot-marie-tooth disease 10.0
47 tooth disease 10.0
48 erysipelas 10.0
49 nephrotic syndrome 10.0
50 neutropenia 10.0

Graphical network of the top 20 diseases related to Non-Histaminic Angioedema:



Diseases related to Non-Histaminic Angioedema

Symptoms & Phenotypes for Non-Histaminic Angioedema

Human phenotypes related to Non-Histaminic Angioedema:

58 31 (show all 17)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 angioedema 58 31 hallmark (90%) Very frequent (99-80%) HP:0100665
2 pruritus 58 31 frequent (33%) Frequent (79-30%) HP:0000989
3 nausea and vomiting 58 31 frequent (33%) Frequent (79-30%) HP:0002017
4 pedal edema 58 31 frequent (33%) Frequent (79-30%) HP:0010741
5 diarrhea 58 31 frequent (33%) Frequent (79-30%) HP:0002014
6 pulmonary edema 58 31 frequent (33%) Frequent (79-30%) HP:0100598
7 muscle weakness 58 31 occasional (7.5%) Occasional (29-5%) HP:0001324
8 peripheral neuropathy 58 31 occasional (7.5%) Occasional (29-5%) HP:0009830
9 skin rash 58 31 occasional (7.5%) Occasional (29-5%) HP:0000988
10 ascites 58 31 occasional (7.5%) Occasional (29-5%) HP:0001541
11 palpebral edema 58 31 occasional (7.5%) Occasional (29-5%) HP:0100540
12 glomerulopathy 58 31 occasional (7.5%) Occasional (29-5%) HP:0100820
13 ovarian cyst 58 31 occasional (7.5%) Occasional (29-5%) HP:0000138
14 lymphoproliferative disorder 58 31 occasional (7.5%) Occasional (29-5%) HP:0005523
15 abnormal lymphocyte morphology 31 occasional (7.5%) HP:0004332
16 edema 58 Very frequent (99-80%)
17 abnormality of lymphocytes 58 Occasional (29-5%)

Drugs & Therapeutics for Non-Histaminic Angioedema

Drugs for Non-Histaminic Angioedema (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 27)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azithromycin Approved Phase 4 83905-01-5 447043 55185
2
Esomeprazole Approved, Investigational Phase 4 161796-78-7, 119141-88-7, 161973-10-0 9568614 4594
3
Ethanol Approved Phase 4 64-17-5 702
4 Antacids Phase 4
5 Anti-Ulcer Agents Phase 4
6 Proton Pump Inhibitors Phase 4
7 Hormones Phase 4
8 Complement System Proteins Phase 2, Phase 3
9
Gemcitabine Approved Phase 2 95058-81-4 60750
10
Rifaximin Approved, Investigational Phase 2 80621-81-4 6436173 46783403
11 Immunologic Factors Phase 2
12 Immunosuppressive Agents Phase 2
13 Antiviral Agents Phase 2
14 Antimetabolites Phase 2
15 Anti-Bacterial Agents Phase 2
16 Anti-Infective Agents Phase 2
17 Gastrointestinal Agents Phase 2
18
Icatibant Approved, Investigational Phase 1 138614-30-9, 130308-48-4 71364
19
Bradykinin Investigational Phase 1 58-82-2 439201
20 Kininogens Phase 1
21 Angiotensin-Converting Enzyme Inhibitors Phase 1
22 Analgesics Phase 1
23 Analgesics, Non-Narcotic Phase 1
24 Anti-Inflammatory Agents Phase 1
25 Bradykinin Receptor Antagonists Phase 1
26 Anti-Inflammatory Agents, Non-Steroidal Phase 1
27 Antirheumatic Agents Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Prospective, Randomized, Placebo-controlled Trial of Pre-transplant and Prompt Post-transplant Treatment With Azithromycin to Improve Early Allograft Function and Outcome After Lung Transplantation Completed NCT01915082 Phase 4 Azithromycin;Ora-Plus
2 Effects of Esomeprazole on Gastric Emptying of Alcoholic Beverages, Blood Alcohol Concentrations, Gastroesophageal Reflux and Release of Some Gastrointestinal Hormones in Healthy Volunteers Completed NCT00472550 Phase 4 esomeprazole 20 mg
3 Pharmacokinetics, Clinical Efficacy and Safety of C1 Inhibitor Concentrate (C1-Esteraseremmer-N) for the Treatment of Hereditary (and Acquired) Angioedema Completed NCT00125541 Phase 2, Phase 3 C1 inhibitor concentrate (C1-esteraseremmer-N)
4 Pharmacokinetics, Clinical Efficacy and Safety of C1 Inhibitor Concentrate (C1-Esteraseremmer-N) for the Treatment of Hereditary (and Acquired) Angioedema Completed NCT00125151 Phase 3 C1 inhibitor concentrate (C1-esteraseremmer-N)
5 Pharmacokinetics, Clinical Efficacy and Safety of C1 Inhibitor Concentrate (C1-Esteraseremmer-N) for the Treatment of Hereditary (and Acquired) Angioedema Completed NCT00119431 Phase 2 C1 inhibitor concentrate
6 A Phase II Clinical Trial to Evaluate the Potential of Concomitant Chemoradiotherapy With Gemcitabine in Patients With Locally Advanced Carcinoma of Cervix and Renal Disease Recruiting NCT03101995 Phase 2 Gemcitabine
7 Pilot, Single Center, Open, Trial of Rifaximin in Probable Alzheimer's Disease Suspended NCT03856359 Phase 2 Rifaximin 550 milligrams (MG)
8 Study of a Bradykinin Receptor Blocker in Angiotensin Converting Enzyme Inhibitor-Associated Angioedema Terminated NCT00517582 Phase 1 HOE-140

Search NIH Clinical Center for Non-Histaminic Angioedema

Genetic Tests for Non-Histaminic Angioedema

Anatomical Context for Non-Histaminic Angioedema

MalaCards organs/tissues related to Non-Histaminic Angioedema:

40
Bone, Lung, Skin, Cervix

Publications for Non-Histaminic Angioedema

Articles related to Non-Histaminic Angioedema:

# Title Authors PMID Year
1
Hereditary angioedema: a current state-of-the-art review, II: historical perspective of non-histamine-induced angioedema. 61
18220145 2008

Variations for Non-Histaminic Angioedema

ClinVar genetic disease variations for Non-Histaminic Angioedema:

6 ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 F12 NM_000505.3(F12):c.983C>G (p.Thr328Arg)SNV Pathogenic 1170 rs118204456 5:176831232-176831232 5:177404231-177404231
2 SERPING1 NM_000062.3(SERPING1):c.1475T>C (p.Met492Thr)SNV Likely pathogenic 427759 rs978962357 11:57382026-57382026 11:57614553-57614553
3 SERPING1 NM_000062.3(SERPING1):c.51+1deldeletion Likely pathogenic 689535 11:57365792-57365792 11:57598319-57598319
4 SERPING1 NM_000062.3(SERPING1):c.369C>G (p.Cys123Trp)SNV Uncertain significance 689536 11:57367669-57367669 11:57600196-57600196
5 SERPING1 NM_000062.3(SERPING1):c.1249+5G>CSNV Uncertain significance 689537 11:57379414-57379414 11:57611941-57611941
6 SYTL2 NM_032943.4(SYTL2):c.890del (p.Ser297fs)deletion Uncertain significance 375385 rs1057519445 11:85445479-85445479 11:85734436-85734436

Expression for Non-Histaminic Angioedema

Search GEO for disease gene expression data for Non-Histaminic Angioedema.

Pathways for Non-Histaminic Angioedema

GO Terms for Non-Histaminic Angioedema

Sources for Non-Histaminic Angioedema

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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