MCID: NNH013
MIFTS: 30

Non-Histaminic Angioedema

Categories: Bone diseases, Immune diseases, Rare diseases

Aliases & Classifications for Non-Histaminic Angioedema

MalaCards integrated aliases for Non-Histaminic Angioedema:

Name: Non-Histaminic Angioedema 58
Non Histamine-Induced Angioedema 58
Bradykinine-Induced Angioedema 58
Angioneurotic Edema 58

Characteristics:

Orphanet epidemiological data:

58
non-histaminic angioedema
Inheritance: Autosomal dominant,Not applicable; Age of onset: All ages; Age of death: normal life expectancy;

Classifications:

Orphanet: 58  
Rare systemic and rhumatological diseases
Rare allergic disease


Summaries for Non-Histaminic Angioedema

MalaCards based summary : Non-Histaminic Angioedema, also known as non histamine-induced angioedema, is related to angioedema and angioedema, hereditary, type i. An important gene associated with Non-Histaminic Angioedema is F12 (Coagulation Factor XII). The drugs Azithromycin and Ethanol have been mentioned in the context of this disorder. Affiliated tissues include bone, lung and skin, and related phenotypes are angioedema and nausea and vomiting

Related Diseases for Non-Histaminic Angioedema

Diseases related to Non-Histaminic Angioedema via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 93)
# Related Disease Score Top Affiliating Genes
1 angioedema 31.6 SYTL2 F12
2 angioedema, hereditary, type i 12.2
3 hereditary angioedema 12.2
4 angioedema induced by ace inhibitors 12.0
5 angioedema, hereditary, type iii 11.8
6 hereditary angioedema with c1inh deficiency 11.6
7 hereditary angioedema with normal c1inh 11.6
8 acquired angioedema with c1inh deficiency 11.6
9 acquired angioedema type 1 11.4
10 acquired angioedema type 2 11.4
11 hydrops, lactic acidosis, and sideroblastic anemia 11.3
12 urticaria 10.6
13 c1 inhibitor deficiency 10.4
14 complement component 4, partial deficiency of 10.4
15 lupus erythematosus 10.3
16 systemic lupus erythematosus 10.3
17 exanthem 10.3
18 autoimmune disease 10.2
19 kearns-sayre syndrome 10.2
20 allergic hypersensitivity disease 10.2
21 glomerulonephritis 10.2
22 ige responsiveness, atopic 10.1
23 erythema multiforme 10.1
24 disseminated intravascular coagulation 10.1
25 conjunctivitis 10.1
26 crohn's disease 10.1
27 granulocytopenia 10.1
28 coproporphyria, hereditary 10.0
29 intussusception 10.0
30 cyclic neutropenia 10.0
31 vitiligo-associated multiple autoimmune disease susceptibility 6 10.0
32 celiac disease 1 10.0
33 myxedema 10.0
34 helicobacter pylori infection 10.0
35 stroke, ischemic 10.0
36 vitiligo-associated multiple autoimmune disease susceptibility 1 10.0
37 nasopharyngeal carcinoma 10.0
38 severe cutaneous adverse reaction 10.0
39 alpha-1-antitrypsin deficiency 10.0
40 hereditary lymphedema 10.0
41 hemorrhagic cystitis 10.0
42 pain agnosia 10.0
43 crohn's colitis 10.0
44 lymphoproliferative syndrome 10.0
45 charcot-marie-tooth disease 10.0
46 tooth disease 10.0
47 erysipelas 10.0
48 nephrotic syndrome 10.0
49 neutropenia 10.0
50 graves' disease 10.0

Graphical network of the top 20 diseases related to Non-Histaminic Angioedema:



Diseases related to Non-Histaminic Angioedema

Symptoms & Phenotypes for Non-Histaminic Angioedema

Human phenotypes related to Non-Histaminic Angioedema:

58 31 (show all 18)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 angioedema 58 31 hallmark (90%) Very frequent (99-80%) HP:0100665
2 nausea and vomiting 58 31 frequent (33%) Frequent (79-30%) HP:0002017
3 pruritus 58 31 frequent (33%) Frequent (79-30%) HP:0000989
4 diarrhea 58 31 frequent (33%) Frequent (79-30%) HP:0002014
5 pulmonary edema 58 31 frequent (33%) Frequent (79-30%) HP:0100598
6 pedal edema 31 frequent (33%) HP:0010741
7 muscle weakness 58 31 occasional (7.5%) Occasional (29-5%) HP:0001324
8 ascites 58 31 occasional (7.5%) Occasional (29-5%) HP:0001541
9 skin rash 58 31 occasional (7.5%) Occasional (29-5%) HP:0000988
10 peripheral neuropathy 58 31 occasional (7.5%) Occasional (29-5%) HP:0009830
11 glomerulopathy 58 31 occasional (7.5%) Occasional (29-5%) HP:0100820
12 palpebral edema 58 31 occasional (7.5%) Occasional (29-5%) HP:0100540
13 lymphoproliferative disorder 58 31 occasional (7.5%) Occasional (29-5%) HP:0005523
14 ovarian cyst 58 31 occasional (7.5%) Occasional (29-5%) HP:0000138
15 abnormal lymphocyte morphology 31 occasional (7.5%) HP:0004332
16 edema 58 Very frequent (99-80%)
17 edema of the lower limbs 58 Frequent (79-30%)
18 abnormality of lymphocytes 58 Occasional (29-5%)

Drugs & Therapeutics for Non-Histaminic Angioedema

Drugs for Non-Histaminic Angioedema (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 34)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azithromycin Approved Phase 4 83905-01-5 55185 447043
2
Ethanol Approved Phase 4 64-17-5 702
3
Esomeprazole Approved, Investigational Phase 4 161796-78-7, 161973-10-0, 119141-88-7 9568614 4594
4 Proton Pump Inhibitors Phase 4
5 Anti-Ulcer Agents Phase 4
6 Hormones Phase 4
7 Antacids Phase 4
8 Complement System Proteins Phase 2, Phase 3
9 Complement Inactivating Agents Phase 2, Phase 3
10 Complement C1 Inactivator Proteins Phase 2, Phase 3
11 Complement C1 Inhibitor Protein Phase 2, Phase 3
12
Rifaximin Approved, Investigational Phase 2 80621-81-4 6436173 46783403
13
Gemcitabine Approved Phase 2 95058-81-4 60750
14 Immunologic Factors Phase 2
15 Immunosuppressive Agents Phase 2
16 Anti-Bacterial Agents Phase 2
17 Anti-Infective Agents Phase 2
18 Gastrointestinal Agents Phase 2
19 Antiviral Agents Phase 2
20 Antimetabolites Phase 2
21
Icatibant Approved, Investigational Phase 1 130308-48-4, 138614-30-9 71364
22
Cysteine Approved, Nutraceutical Phase 1 52-90-4 5862
23
Bradykinin Investigational Phase 1 58-82-2 439201
24 Analgesics Phase 1
25 HIV Protease Inhibitors Phase 1
26
protease inhibitors Phase 1
27 Anti-Inflammatory Agents Phase 1
28 Anti-Inflammatory Agents, Non-Steroidal Phase 1
29 Analgesics, Non-Narcotic Phase 1
30 Kininogens Phase 1
31 Antirheumatic Agents Phase 1
32 Angiotensin-Converting Enzyme Inhibitors Phase 1
33 Bradykinin Receptor Antagonists Phase 1
34 Vasodilator Agents Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Prospective, Randomized, Placebo-controlled Trial of Pre-transplant and Prompt Post-transplant Treatment With Azithromycin to Improve Early Allograft Function and Outcome After Lung Transplantation Completed NCT01915082 Phase 4 Azithromycin;Ora-Plus
2 Effects of Esomeprazole on Gastric Emptying of Alcoholic Beverages, Blood Alcohol Concentrations, Gastroesophageal Reflux and Release of Some Gastrointestinal Hormones in Healthy Volunteers Completed NCT00472550 Phase 4 esomeprazole 20 mg
3 Pharmacokinetics, Clinical Efficacy and Safety of C1 Inhibitor Concentrate (C1-Esteraseremmer-N) for the Treatment of Hereditary (and Acquired) Angioedema Completed NCT00125541 Phase 2, Phase 3 C1 inhibitor concentrate (C1-esteraseremmer-N)
4 Pharmacokinetics, Clinical Efficacy and Safety of C1 Inhibitor Concentrate (C1-Esteraseremmer-N) for the Treatment of Hereditary (and Acquired) Angioedema Completed NCT00125151 Phase 3 C1 inhibitor concentrate (C1-esteraseremmer-N)
5 Pharmacokinetics, Clinical Efficacy and Safety of C1 Inhibitor Concentrate (C1-Esteraseremmer-N) for the Treatment of Hereditary (and Acquired) Angioedema Completed NCT00119431 Phase 2 C1 inhibitor concentrate
6 Pilot, Single Center, Open, Trial of Rifaximin in Probable Alzheimer's Disease Recruiting NCT03856359 Phase 2 Rifaximin 550 milligrams (MG)
7 A Phase II Clinical Trial to Evaluate the Potential of Concomitant Chemoradiotherapy With Gemcitabine in Patients With Locally Advanced Carcinoma of Cervix and Renal Disease Recruiting NCT03101995 Phase 2 Gemcitabine
8 Study of a Bradykinin Receptor Blocker in Angiotensin Converting Enzyme Inhibitor-Associated Angioedema Terminated NCT00517582 Phase 1 HOE-140

Search NIH Clinical Center for Non-Histaminic Angioedema

Genetic Tests for Non-Histaminic Angioedema

Anatomical Context for Non-Histaminic Angioedema

MalaCards organs/tissues related to Non-Histaminic Angioedema:

40
Bone, Lung, Skin, Cervix, Pancreas, Thyroid

Publications for Non-Histaminic Angioedema

Articles related to Non-Histaminic Angioedema:

# Title Authors PMID Year
1
Hereditary angioedema: a current state-of-the-art review, II: historical perspective of non-histamine-induced angioedema. 61
18220145 2008

Variations for Non-Histaminic Angioedema

ClinVar genetic disease variations for Non-Histaminic Angioedema:

6 ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 F12 NM_000505.3(F12):c.983C>G (p.Thr328Arg)SNV Pathogenic 1170 rs118204456 5:176831232-176831232 5:177404231-177404231
2 SYTL2 NM_032943.4(SYTL2):c.890del (p.Ser297fs)deletion Pathogenic 375385 rs1057519445 11:85445479-85445479 11:85734436-85734436
3 SERPING1 NM_000062.2(SERPING1):c.1475T>C (p.Met492Thr)SNV Likely pathogenic 427759 rs978962357 11:57382026-57382026 11:57614553-57614553
4 SERPING1 NM_000062.3(SERPING1):c.51+1deldeletion Likely pathogenic 689535 11:57365792-57365792 11:57598319-57598319
5 SERPING1 NM_000062.3(SERPING1):c.369C>G (p.Cys123Trp)SNV Uncertain significance 689536 11:57367669-57367669 11:57600196-57600196
6 SERPING1 NM_000062.3(SERPING1):c.1249+5G>CSNV Uncertain significance 689537 11:57379414-57379414 11:57611941-57611941

Expression for Non-Histaminic Angioedema

Search GEO for disease gene expression data for Non-Histaminic Angioedema.

Pathways for Non-Histaminic Angioedema

GO Terms for Non-Histaminic Angioedema

Sources for Non-Histaminic Angioedema

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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