NICH
MCID: NNN007
MIFTS: 33

Non-Involuting Congenital Hemangioma (NICH)

Categories: Blood diseases, Cardiovascular diseases, Fetal diseases, Rare diseases

Aliases & Classifications for Non-Involuting Congenital Hemangioma

MalaCards integrated aliases for Non-Involuting Congenital Hemangioma:

Name: Non-Involuting Congenital Hemangioma 52 58 71
Nich 52 58
Noninvoluting Congenital Hemangioma 52

Characteristics:

Orphanet epidemiological data:

58
non-involuting congenital hemangioma
Inheritance: Not applicable; Age of onset: Infancy,Neonatal; Age of death: normal life expectancy;

Classifications:

Orphanet: 58  
Rare circulatory system diseases
Developmental anomalies during embryogenesis


External Ids:

ICD10 via Orphanet 33 D18.0
UMLS via Orphanet 72 C1275417
Orphanet 58 ORPHA141179
UMLS 71 C1275417

Summaries for Non-Involuting Congenital Hemangioma

NIH Rare Diseases : 52 Non-involuting congenital hemangioma (NICH) is a rare type of infantile hemangioma , which is a tumor that forms from the abnormal growth of blood vessels in the skin. NICH looks like an oval, purplish mark or bump that can occur on any part of the body. NICH is present from birth (congenital ) and increases in size as the child grows. Unlike other hemangiomas, NICH do not disappear spontaneously (involute ).

MalaCards based summary : Non-Involuting Congenital Hemangioma, also known as nich, is related to hemangioma and glioblastoma multiforme. The drugs Decitabine and Cytarabine have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and prostate, and related phenotypes are telangiectasia of the skin and subcutaneous calcification

Wikipedia : 74 A vascular tumor is a tumor of vascular origin; a soft tissue growth that can be either benign or... more...

Related Diseases for Non-Involuting Congenital Hemangioma

Diseases related to Non-Involuting Congenital Hemangioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 669)
# Related Disease Score Top Affiliating Genes
1 hemangioma 10.5
2 glioblastoma multiforme 10.5
3 leukemia, acute myeloid 10.5
4 congenital hemangioma 10.4
5 myeloid leukemia 10.4
6 myeloma, multiple 10.4
7 leukemia 10.3
8 kala-azar 1 10.3
9 lymphocytic leukemia 10.3
10 leishmaniasis 10.3
11 glioma 10.3
12 glial tumor 10.3
13 aging 10.3
14 myelodysplastic syndrome 10.2
15 leukemia, acute lymphoblastic 10.2
16 hypoxia 10.2
17 chagas disease 10.2
18 severe combined immunodeficiency 10.2
19 cutaneous leishmaniasis 10.2
20 von willebrand's disease 10.2
21 mechanical ectropion 10.2
22 ectropion 10.2
23 hemangioendothelioma 10.2
24 kaposiform hemangioendothelioma 10.2
25 rare vascular tumor 10.2
26 hair whorl 10.2
27 ovarian cancer 10.2
28 pancreatic cancer 10.2
29 autoimmune lymphoproliferative syndrome 10.2
30 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.1
31 melanoma 10.1
32 anaplastic oligoastrocytoma 10.1
33 spinal cord injury 10.1
34 polyploidy 10.1
35 colorectal cancer 10.1
36 triiodothyronine receptor auxiliary protein 10.1
37 cytokine deficiency 10.1
38 limbal stem cell deficiency 10.1
39 angioma, tufted 10.1
40 telangiectasis 10.1
41 thrombocytopenia 10.1
42 hemolytic anemia 10.1
43 pyogenic granuloma 10.1
44 rapidly involuting congenital hemangioma 10.1
45 autoimmune disease 10.1
46 graft-versus-host disease 10.1
47 bone resorption disease 10.1
48 visceral leishmaniasis 10.1
49 myelofibrosis 10.1
50 leukemia, chronic lymphocytic 10.0

Graphical network of the top 20 diseases related to Non-Involuting Congenital Hemangioma:



Diseases related to Non-Involuting Congenital Hemangioma

Symptoms & Phenotypes for Non-Involuting Congenital Hemangioma

Human phenotypes related to Non-Involuting Congenital Hemangioma:

58 31 (show all 12)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 telangiectasia of the skin 58 31 frequent (33%) Frequent (79-30%) HP:0100585
2 subcutaneous calcification 58 31 frequent (33%) Frequent (79-30%) HP:0007618
3 midfrontal capillary hemangioma 58 31 frequent (33%) Frequent (79-30%) HP:0007466
4 perineal hemangioma 58 31 frequent (33%) Frequent (79-30%) HP:0031449
5 congestive heart failure 58 31 occasional (7.5%) Occasional (29-5%) HP:0001635
6 thrombocytopenia 58 31 occasional (7.5%) Occasional (29-5%) HP:0001873
7 peripheral arteriovenous fistula 58 31 occasional (7.5%) Occasional (29-5%) HP:0100784
8 prominent superficial veins 58 31 occasional (7.5%) Occasional (29-5%) HP:0001015
9 hepatic hemangioma 58 31 occasional (7.5%) Occasional (29-5%) HP:0031207
10 hemangioma 58 Obligate (100%)
11 visceral hemangioma 58 Occasional (29-5%)
12 tufted angioma 58 Excluded (0%)

Drugs & Therapeutics for Non-Involuting Congenital Hemangioma

Drugs for Non-Involuting Congenital Hemangioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Decitabine Approved, Investigational Phase 2 2353-33-5 451668
2
Cytarabine Approved, Experimental, Investigational Phase 2 147-94-4, 65-46-3 6253
3 Immunologic Factors Phase 2
4 Anti-Infective Agents Phase 2
5 Antiviral Agents Phase 2
6 Immunosuppressive Agents Phase 2
7 Antimetabolites Phase 2
8
Progesterone Approved, Vet_approved Phase 1 57-83-0 5994
9 Hormone Antagonists Phase 1
10 Hormones Phase 1
11 Progestins Phase 1
12
Zinc Approved, Investigational 7440-66-6 32051
13
Zinc sulfate Approved, Investigational 7733-02-0
14 Astringents
15 Nutrients
16 Dermatologic Agents
17 Trace Elements
18 Micronutrients

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Multicenter Randomized Control Clinical Trail of Evaluating Effect of Demethylation Drug Combined With Chemotherapy in Patients With Intermediate-risk AML After Hematological Complete Remission Recruiting NCT03417427 Phase 2 Decitabine and Ara-C;Ara-C
2 Sex Differences in Progesterone Effects on Responses to Stress and Drug Cues Completed NCT00585520 Phase 1 Progesterone;Placebo
3 Thermal Images on Smartphones to Diagnose Bacterial Pneumonia in Children in Pakistan Unknown status NCT02908399
4 Comparing the Efficacy of Different Zinc Formulations in the Treatment of Acute Diarrhea Among Young Children at Hospital Based Setting in Pakistan Completed NCT00682955 Zinc Sulphate;Zinc Sulphate

Search NIH Clinical Center for Non-Involuting Congenital Hemangioma

Genetic Tests for Non-Involuting Congenital Hemangioma

Anatomical Context for Non-Involuting Congenital Hemangioma

MalaCards organs/tissues related to Non-Involuting Congenital Hemangioma:

40
Skin, Bone, Prostate, Brain, T Cells, Liver, Lung

Publications for Non-Involuting Congenital Hemangioma

Articles related to Non-Involuting Congenital Hemangioma:

(show top 50) (show all 89)
# Title Authors PMID Year
1
A case series of Tardive Expansion Congenital Hemangioma: a Variation of NICH or a New Hemangiomatous Entity? 61
32032694 2020
2
Evaluation of Stromal Myofibroblasts in Laryngeal Dysplasia and Invasive Squamous Cell Carcinoma. 61
31741965 2019
3
Congenital hemangioma exhibiting postnatal growth. 61
30900306 2019
4
Non-involuting congenital hemangiomas (NICH) with postnatal atypical growth: A case series. 61
31033005 2019
5
Selecting and identifying gas-phase protonation isomers of nicotineH+ using combined laser, ion mobility and mass spectrometry techniques. 61
31012453 2019
6
Perceptions of parents and religious leaders regarding minimal invasive tissue sampling to identify the cause of death in stillbirths and neonates: results from a qualitative study. 61
31077244 2019
7
Intracerebral hemorrhage associated with warfarin versus non-vitamin K antagonist oral anticoagulants in Asian patients. 61
30587420 2019
8
Non-islet Cell Hypoglycemia: Case Series and Review of the Literature. 61
31156561 2019
9
Disease Spectrum and Frequency of Illness in Pediatric Emergency: A Retrospective Analysis From Karachi, Pakistan. 61
31903057 2019
10
Perceptions of health professionals regarding minimally invasive tissue sampling (MITS) to identify the cause of death in stillbirths and neonates: results from a qualitative study. 61
31666979 2019
11
Congenital anomalies in children born in the Czech Republic in 1994-2015. 61
31046386 2019
12
Intussusception among children less than 2years of age: Findings from pre-vaccine introduction surveillance in Pakistan. 61
28709556 2018
13
Comparison of Classical and Non-Classical Turner Syndrome at NICH Karachi. 61
30369375 2018
14
Perceptions of parents and healthcare professionals regarding minimal invasive tissue sampling to identify the cause of death in stillbirths and neonates: a qualitative study protocol. 61
30348179 2018
15
[Clinical characteristics and prognosis of long-term glucocorticoid users with community-acquired pneumonia]. 61
29562397 2018
16
Control of Chain Walking by Weak Neighboring Group Interactions in Unsymmetrical Catalysts. 61
29261306 2018
17
Risk factors and clinical characteristics of non-promyelocytic acute myeloid leukemia of intracerebral hemorrhage: A single center study in China. 61
28694043 2017
18
Minor Nonintracranial Hemorrhage and Poor Prognosis among Stroke Patients Undergoing Intravenous Thrombolysis. 61
28624140 2017
19
Report - Colonization rates and immune status of children against Streptococcus pneumoniae before the introduction of pneumococcal conjugate vaccine. 61
29084703 2017
20
Carboxylate Counteranions in Electronic Cigarette Liquids: Influence on Nicotine Emissions. 61
28686840 2017
21
[Vascular anomalies in the neonatal period]. 61
29043695 2017
22
Parotid gland tumors. Results of retrospective analysis of 149 patients treated at the Clinical Department of Cranio-Maxillofacial Surgery, Clinic of Otolaryngology and Oncologic Laryngology of Military Institute of Medicine in Warsaw in years 2006-2016. 61
28541244 2017
23
NICH at Its Best for Diabetes at Its Worst: Texting Teens and Their Caregivers for Better Outcomes. 61
28745094 2017
24
Partnering with Insurers in Caring for the Most Vulnerable Youth with Diabetes: NICH as an Integrator. 61
28321766 2017
25
[Retrospective analysis of 117 cases of pulmonary cryptococcosis]. 61
27852362 2016
26
Texting Adolescents in Repeat DKA and Their Caregivers. 61
27030051 2016
27
Somatic Activating Mutations in GNAQ and GNA11 Are Associated with Congenital Hemangioma. 61
27058448 2016
28
Correlation of CD24 expression with histological grading and TNM staging of retinoblastoma. 61
27022367 2016
29
Frequency and Mortality Associated with Hyperglycemia in Critically Ill Children. 61
26691362 2015
30
Free-Base and Protonated Nicotine in Electronic Cigarette Liquids and Aerosols. 61
26158618 2015
31
Reactions of phenylacetylene with nickel POCOP-pincer hydride complexes resulting in different outcomes from their palladium analogues. 61
25773963 2015
32
[Congenital hemangiomas: Report on ten patients]. 61
26047746 2015
33
[Clinicopathologic features and differential diagnoses of non-involuting congenital hemangioma in children]. 61
26705041 2015
34
Rapidly involuting congenital hemangioma with fetal involution. 61
25492638 2015
35
Novel Interventions in Children's Healthcare for Youth Hospitalized for Chronic Pain. 61
26535168 2015
36
Rapidly involuting congenital hemangioma (RICH): a brief case report. 61
25419759 2014
37
Youth repeatedly hospitalized for DKA: proof of concept for novel interventions in children's healthcare (NICH). 61
24855164 2014
38
Characteristics of noninvoluting congenital hemangioma: a retrospective review. 61
24630000 2014
39
Non-involuting congenital haemangioma of the eyelid: successful treatment with fluroscopic ultrasound guided sclerotherapy and surgical excision. 61
23188816 2014
40
Partially involuting congenital hemangiomas: a report of 8 cases and review of the literature. 61
24176519 2014
41
Propranolol responsiveness in vascular tumors is not determined by qualitative differences in adrenergic receptors. 61
24009211 2013
42
Reasons for non-vaccination in pediatric patients visiting tertiary care centers in a polio-prone country. 61
23848348 2013
43
Baseline thrombocytopenia complicated by recurrent episodes of transient severe thrombocytopenia following infections in an adult woman with a non involuting congenital hemangioma - a case report. 61
23758712 2013
44
The role of children with congenital anomalies in generating parental depressive symptoms. 61
24922987 2013
45
Management of impacted urethral stones in children. 61
22868017 2012
46
[Hemangioma. New aspects of pathogenesis, differential diagnosis and therapy]. 61
22349036 2012
47
New understandings of the genetic basis of isolated idiopathic central hypogonadism. 61
22138902 2012
48
Prenatal diagnosis and postnatal follow-up of rapidly involuting congenital hemangioma (RICH). 61
21337126 2011
49
National identification of Dutch youth: an exploratory study. 61
20673993 2011
50
[Comparative study on pathology of non involuting congenital hemangioma and infantile hemangioma]. 61
21837995 2011

Variations for Non-Involuting Congenital Hemangioma

Expression for Non-Involuting Congenital Hemangioma

Search GEO for disease gene expression data for Non-Involuting Congenital Hemangioma.

Pathways for Non-Involuting Congenital Hemangioma

GO Terms for Non-Involuting Congenital Hemangioma

Sources for Non-Involuting Congenital Hemangioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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