MCID: NNP005
MIFTS: 29

Non-Proliferative Fibrocystic Change of the Breast

Categories: Cancer diseases

Aliases & Classifications for Non-Proliferative Fibrocystic Change of the Breast

MalaCards integrated aliases for Non-Proliferative Fibrocystic Change of the Breast:

Name: Non-Proliferative Fibrocystic Change of the Breast 12 15
Breast Fibrocystic Change, Non-Proliferative Type 73
Non-Proliferative Fibrocystic Change 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5997
NCIt 50 C6943
UMLS 73 C1332628

Summaries for Non-Proliferative Fibrocystic Change of the Breast

Disease Ontology : 12 A breast fibrocystic disease that is characterized by the absence of epithelial cell hyperplasia.

MalaCards based summary : Non-Proliferative Fibrocystic Change of the Breast, also known as breast fibrocystic change, non-proliferative type, is related to apocrine adenosis of breast and fibrosclerosis of breast. An important gene associated with Non-Proliferative Fibrocystic Change of the Breast is MYCL (MYCL Proto-Oncogene, BHLH Transcription Factor), and among its related pathways/superpathways are Development EGFR signaling pathway and MicroRNAs in cancer. Affiliated tissues include breast, lung and bone, and related phenotypes are Increased viability with nutlin-3 and embryo

Related Diseases for Non-Proliferative Fibrocystic Change of the Breast

Diseases related to Non-Proliferative Fibrocystic Change of the Breast via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 92)
# Related Disease Score Top Affiliating Genes
1 apocrine adenosis of breast 32.4 ERBB2 MYCL
2 fibrosclerosis of breast 31.9 ENG NPM1 SRY XRCC1
3 oral leukoplakia 10.1 TP53 XRCC1
4 cerebral primitive neuroectodermal tumor 10.1 MYCL TP53
5 cardia cancer 10.1 TP53 XRCC1
6 maxillary cancer 10.1 SRY TP53
7 gastric papillary adenocarcinoma 10.0 ERBB2 TP53
8 papillary adenocarcinoma 10.0 ERBB2 TP53
9 pleomorphic adenoma carcinoma 10.0 ERBB2 TP53
10 uterine corpus serous adenocarcinoma 10.0 ERBB2 TP53
11 breast squamous cell carcinoma 10.0 ERBB2 TP53
12 uterine body mixed cancer 10.0 ERBB2 TP53
13 glioma susceptibility 1 10.0 ERBB2 TP53
14 microglandular adenosis 10.0 ERBB2 TP53
15 esophagus adenocarcinoma 10.0 ERBB2 TP53
16 breast benign neoplasm 10.0 ERBB2 TP53
17 thoracic benign neoplasm 10.0 ERBB2 TP53
18 uterine corpus cancer 10.0 ERBB2 TP53
19 mixed cell type cancer 10.0 ERBB2 TP53
20 granulosa cell tumor of the ovary 10.0 ERBB2 TP53
21 primary peritoneal carcinoma 10.0 ERBB2 TP53
22 tonsil cancer 10.0 ERBB2 TP53
23 fallopian tube carcinoma 10.0 ERBB2 TP53
24 barrett's adenocarcinoma 10.0 ERBB2 TP53
25 ovary adenocarcinoma 10.0 ERBB2 TP53
26 in situ carcinoma 10.0 ERBB2 TP53
27 breast carcinoma in situ 10.0 ERBB2 TP53
28 ovarian cancer 1 10.0 ERBB2 TP53
29 synchronous bilateral breast carcinoma 10.0 CCND1 TP53
30 malignant ovarian surface epithelial-stromal neoplasm 10.0 ERBB2 TP53
31 cll/sll 10.0 CCND1 TP53
32 ovary epithelial cancer 10.0 ERBB2 TP53
33 verrucous carcinoma 9.9 CCND1 TP53
34 female breast cancer 9.9 ERBB2 TP53
35 breast papillomatosis 9.9 CCND1 ERBB2
36 keratocystic odontogenic tumor 9.9 CCND1 TP53
37 oropharynx cancer 9.9 CCND1 TP53
38 pharynx cancer 9.9 CCND1 TP53
39 intestinal benign neoplasm 9.9 CCND1 TP53
40 inverted papilloma 9.9 CCND1 TP53
41 sporadic breast cancer 9.9 ERBB2 TP53 XRCC1
42 penile cancer 9.9 CCND1 TP53
43 serous cystadenocarcinoma 9.9 ERBB2 TP53
44 nasopharyngeal disease 9.9 CCND1 TP53
45 hematologic cancer 9.9 ENG NPM1 TP53
46 retinal cancer 9.9 CCND1 TP53
47 atypical teratoid rhabdoid tumor 9.9 CCND1 TP53
48 cystadenocarcinoma 9.9 ERBB2 TP53
49 gonadal disease 9.9 ERBB2 SRY TP53
50 cervical adenocarcinoma 9.9 ERBB2 TP53

Graphical network of the top 20 diseases related to Non-Proliferative Fibrocystic Change of the Breast:



Diseases related to Non-Proliferative Fibrocystic Change of the Breast

Symptoms & Phenotypes for Non-Proliferative Fibrocystic Change of the Breast

GenomeRNAi Phenotypes related to Non-Proliferative Fibrocystic Change of the Breast according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability with nutlin-3 GR00123-A 8.62 MYCL TP53

MGI Mouse Phenotypes related to Non-Proliferative Fibrocystic Change of the Breast:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 embryo MP:0005380 9.72 ENG ERBB2 NPM1 TP53 XRCC1
2 mortality/aging MP:0010768 9.7 CCND1 ENG ERBB2 MYCL NPM1 TP53
3 integument MP:0010771 9.65 CCND1 ENG ERBB2 NPM1 TP53
4 neoplasm MP:0002006 9.35 CCND1 ERBB2 NPM1 TP53 XRCC1
5 normal MP:0002873 9.1 CCND1 ENG ERBB2 MYCL TP53 XRCC1

Drugs & Therapeutics for Non-Proliferative Fibrocystic Change of the Breast

Search Clinical Trials , NIH Clinical Center for Non-Proliferative Fibrocystic Change of the Breast

Genetic Tests for Non-Proliferative Fibrocystic Change of the Breast

Anatomical Context for Non-Proliferative Fibrocystic Change of the Breast

MalaCards organs/tissues related to Non-Proliferative Fibrocystic Change of the Breast:

41
Breast, Lung, Bone, Colon, Ovary, Pancreas, Thyroid

Publications for Non-Proliferative Fibrocystic Change of the Breast

Variations for Non-Proliferative Fibrocystic Change of the Breast

Expression for Non-Proliferative Fibrocystic Change of the Breast

Search GEO for disease gene expression data for Non-Proliferative Fibrocystic Change of the Breast.

Pathways for Non-Proliferative Fibrocystic Change of the Breast

GO Terms for Non-Proliferative Fibrocystic Change of the Breast

Biological processes related to Non-Proliferative Fibrocystic Change of the Breast according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.5 CCND1 ENG XRCC1
2 cellular response to UV GO:0034644 9.37 NPM1 TP53
3 base-excision repair GO:0006284 9.26 TP53 XRCC1
4 cell aging GO:0007569 9.16 NPM1 TP53
5 positive regulation of protein phosphorylation GO:0001934 9.13 CCND1 ENG ERBB2
6 mitotic G1 DNA damage checkpoint GO:0031571 8.62 CCND1 TP53

Molecular functions related to Non-Proliferative Fibrocystic Change of the Breast according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription factor binding GO:0008134 8.92 CCND1 NPM1 SRY TP53

Sources for Non-Proliferative Fibrocystic Change of the Breast

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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