MCID: NNP005
MIFTS: 30

Non-Proliferative Fibrocystic Change of the Breast

Categories: Cancer diseases

Aliases & Classifications for Non-Proliferative Fibrocystic Change of the Breast

MalaCards integrated aliases for Non-Proliferative Fibrocystic Change of the Breast:

Name: Non-Proliferative Fibrocystic Change of the Breast 12 15
Breast Fibrocystic Change, Non-Proliferative Type 74
Non-Proliferative Fibrocystic Change 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5997
NCIt 51 C6943
UMLS 74 C1332628

Summaries for Non-Proliferative Fibrocystic Change of the Breast

Disease Ontology : 12 A breast fibrocystic disease that is characterized by the absence of epithelial cell hyperplasia.

MalaCards based summary : Non-Proliferative Fibrocystic Change of the Breast, also known as breast fibrocystic change, non-proliferative type, is related to apocrine adenosis of breast and fibrosclerosis of breast. An important gene associated with Non-Proliferative Fibrocystic Change of the Breast is MYCL (MYCL Proto-Oncogene, BHLH Transcription Factor), and among its related pathways/superpathways are ErbB signaling pathway and Development EGFR signaling pathway. Affiliated tissues include ovary, colon and bone, and related phenotypes are Increased viability with nutlin-3 and growth/size/body region

Related Diseases for Non-Proliferative Fibrocystic Change of the Breast

Diseases related to Non-Proliferative Fibrocystic Change of the Breast via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 102)
# Related Disease Score Top Affiliating Genes
1 apocrine adenosis of breast 32.5 ERBB2 MYCL
2 fibrosclerosis of breast 32.2 ENG NPM1 XRCC1
3 cerebral primitive neuroectodermal tumor 10.2 MYCL TP53
4 cardia cancer 10.2 TP53 XRCC1
5 gastric papillary adenocarcinoma 10.1 ERBB2 TP53
6 papillary adenocarcinoma 10.1 ERBB2 TP53
7 pleomorphic adenoma carcinoma 10.1 ERBB2 TP53
8 pleomorphic adenoma 10.1 ERBB2 TP53
9 uterine corpus serous adenocarcinoma 10.1 ERBB2 TP53
10 breast squamous cell carcinoma 10.1 ERBB2 TP53
11 uterine body mixed cancer 10.1 ERBB2 TP53
12 glioma susceptibility 1 10.1 ERBB2 TP53
13 microglandular adenosis 10.1 ERBB2 TP53
14 esophagus adenocarcinoma 10.1 ERBB2 TP53
15 breast benign neoplasm 10.0 ERBB2 TP53
16 thoracic benign neoplasm 10.0 ERBB2 TP53
17 uterine corpus cancer 10.0 ERBB2 TP53
18 mixed cell type cancer 10.0 ERBB2 TP53
19 granulosa cell tumor of the ovary 10.0 ERBB2 TP53
20 primary peritoneal carcinoma 10.0 ERBB2 TP53
21 tonsil cancer 10.0 ERBB2 TP53
22 fallopian tube carcinoma 10.0 ERBB2 TP53
23 ovary adenocarcinoma 10.0 ERBB2 TP53
24 barrett's adenocarcinoma 10.0 ERBB2 TP53
25 in situ carcinoma 10.0 ERBB2 TP53
26 breast carcinoma in situ 10.0 ERBB2 TP53
27 ovarian cancer 1 10.0 ERBB2 TP53
28 malignant ovarian surface epithelial-stromal neoplasm 10.0 ERBB2 TP53
29 ovary epithelial cancer 10.0 ERBB2 TP53
30 female breast cancer 10.0 ERBB2 TP53
31 serous cystadenocarcinoma 10.0 ERBB2 TP53
32 cystadenocarcinoma 10.0 ERBB2 TP53
33 cervical adenocarcinoma 10.0 ERBB2 TP53
34 synchronous bilateral breast carcinoma 9.9 CCND1 TP53
35 cll/sll 9.9 CCND1 TP53
36 verrucous carcinoma 9.9 CCND1 TP53
37 sweat gland cancer 9.9 ERBB2 TP53
38 carcinosarcoma 9.9 ERBB2 TP53
39 keratocystic odontogenic tumor 9.9 CCND1 TP53
40 oropharynx cancer 9.9 CCND1 TP53
41 pharynx cancer 9.9 CCND1 TP53
42 breast papillomatosis 9.9 CCND1 ERBB2
43 intestinal benign neoplasm 9.9 CCND1 TP53
44 inverted papilloma 9.9 CCND1 TP53
45 penile cancer 9.9 CCND1 TP53
46 ovarian serous cystadenocarcinoma 9.9 ERBB2 TP53
47 nasopharyngeal disease 9.9 CCND1 TP53
48 retinal cancer 9.9 CCND1 TP53
49 atypical teratoid rhabdoid tumor 9.9 CCND1 TP53
50 cervix disease 9.9 CCND1 TP53

Graphical network of the top 20 diseases related to Non-Proliferative Fibrocystic Change of the Breast:



Diseases related to Non-Proliferative Fibrocystic Change of the Breast

Symptoms & Phenotypes for Non-Proliferative Fibrocystic Change of the Breast

GenomeRNAi Phenotypes related to Non-Proliferative Fibrocystic Change of the Breast according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability with nutlin-3 GR00123-A 8.62 MYCL TP53

MGI Mouse Phenotypes related to Non-Proliferative Fibrocystic Change of the Breast:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.85 CCND1 ENG ERBB2 NPM1 TP53 XRCC1
2 embryo MP:0005380 9.8 ENG ERBB2 NPM1 TP53 XRCC1
3 mortality/aging MP:0010768 9.8 CCND1 ENG ERBB2 MYCL NPM1 TP53
4 craniofacial MP:0005382 9.73 CCND1 ENG ERBB2 TP53
5 integument MP:0010771 9.72 CCND1 ENG ERBB2 NPM1 TP53
6 neoplasm MP:0002006 9.55 CCND1 ERBB2 NPM1 TP53 XRCC1
7 nervous system MP:0003631 9.43 CCND1 ENG ERBB2 NPM1 TP53 XRCC1
8 normal MP:0002873 9.1 CCND1 ENG ERBB2 MYCL TP53 XRCC1

Drugs & Therapeutics for Non-Proliferative Fibrocystic Change of the Breast

Search Clinical Trials , NIH Clinical Center for Non-Proliferative Fibrocystic Change of the Breast

Genetic Tests for Non-Proliferative Fibrocystic Change of the Breast

Anatomical Context for Non-Proliferative Fibrocystic Change of the Breast

MalaCards organs/tissues related to Non-Proliferative Fibrocystic Change of the Breast:

42
Ovary, Colon, Bone, Tongue, Cervix, Pancreas, Tonsil

Publications for Non-Proliferative Fibrocystic Change of the Breast

Variations for Non-Proliferative Fibrocystic Change of the Breast

Expression for Non-Proliferative Fibrocystic Change of the Breast

Search GEO for disease gene expression data for Non-Proliferative Fibrocystic Change of the Breast.

Pathways for Non-Proliferative Fibrocystic Change of the Breast

Pathways related to Non-Proliferative Fibrocystic Change of the Breast according to GeneCards Suite gene sharing:

(show all 21)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.21 CCND1 ERBB2 TP53
2
Show member pathways
12.19 CCND1 ERBB2 TP53
3 12.15 CCND1 ERBB2 TP53
4 11.8 CCND1 ERBB2 TP53
5
Show member pathways
11.79 CCND1 ERBB2 TP53
6 11.59 CCND1 ERBB2 TP53
7 11.42 ERBB2 TP53
8 11.4 ERBB2 TP53
9 11.4 ENG NPM1
10 11.4 CCND1 NPM1 TP53 XRCC1
11 11.39 CCND1 ERBB2 TP53
12 11.36 CCND1 ERBB2
13 11.3 CCND1 TP53
14 11.27 CCND1 TP53
15 11.26 CCND1 TP53
16 11.24 CCND1 TP53
17 11.15 CCND1 TP53
18 11.02 CCND1 XRCC1
19 11 CCND1 ERBB2 TP53
20 10.91 CCND1 TP53
21 10.83 NPM1 TP53

GO Terms for Non-Proliferative Fibrocystic Change of the Breast

Biological processes related to Non-Proliferative Fibrocystic Change of the Breast according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.5 CCND1 ENG XRCC1
2 cellular response to UV GO:0034644 9.37 NPM1 TP53
3 base-excision repair GO:0006284 9.26 TP53 XRCC1
4 cell aging GO:0007569 9.16 NPM1 TP53
5 positive regulation of protein phosphorylation GO:0001934 9.13 CCND1 ENG ERBB2
6 mitotic G1 DNA damage checkpoint GO:0031571 8.62 CCND1 TP53

Molecular functions related to Non-Proliferative Fibrocystic Change of the Breast according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 9.13 CCND1 TP53 XRCC1
2 transcription factor binding GO:0008134 8.8 CCND1 NPM1 TP53

Sources for Non-Proliferative Fibrocystic Change of the Breast

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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