MCID: NNS003
MIFTS: 28

Non-Secretory Myeloma

Categories: Blood diseases, Cancer diseases

Aliases & Classifications for Non-Secretory Myeloma

MalaCards integrated aliases for Non-Secretory Myeloma:

Name: Non-Secretory Myeloma 12 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:9547
SNOMED-CT 67 277580004
UMLS 71 C0456845

Summaries for Non-Secretory Myeloma

MalaCards based summary : Non-Secretory Myeloma is related to amyloid tumor and heavy chain disease. An important gene associated with Non-Secretory Myeloma is MYOM2 (Myomesin 2), and among its related pathways/superpathways are Cell adhesion molecules (CAMs) and NF-kappaB Signaling. The drugs Doxorubicin and Prednisone have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and skin.

Related Diseases for Non-Secretory Myeloma

Diseases related to Non-Secretory Myeloma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 168)
# Related Disease Score Top Affiliating Genes
1 amyloid tumor 30.5 MYOM2 B2M
2 heavy chain disease 30.4 MYOM2 CD40LG
3 amyloidosis 29.6 MYOM2 CD40LG B2M ALB
4 plasma cell leukemia 29.3 SDC1 NCAM1 CD38
5 myeloma, multiple 27.7 SDC1 NCAM1 MYOM2 IGHV4-38-2 CD40LG CD38
6 monoclonal gammopathy of uncertain significance 27.7 SDC1 NCAM1 MYOM2 IGHV4-38-2 CD40LG CD38
7 plasma cell neoplasm 27.2 SDC1 NCAM1 MYOM2 IGHV4-38-2 CD40LG CD38
8 glomeruloid hemangioma 10.4 SDC1 MYOM2
9 myopathy, lactic acidosis, and sideroblastic anemia 3 10.4 SDC1 MYOM2
10 osteosclerotic myeloma 10.3 MYOM2 CD40LG
11 ecthyma 10.3 MYOM2 CD40LG
12 asymmetric motor neuropathy 10.3 MYOM2 CD40LG
13 alpha chain disease 10.3 MYOM2 CD40LG
14 mononeuritis of upper limb and mononeuritis multiplex 10.3 MYOM2 CD40LG
15 mononeuritis multiplex 10.3 MYOM2 CD40LG
16 polyclonal hypergammaglobulinemia 10.3 MYOM2 CD40LG
17 miller fisher syndrome 10.3 MYOM2 CD40LG
18 mononeuropathy 10.3 MYOM2 CD40LG
19 erysipelas 10.3 MYOM2 CD40LG
20 papilledema 10.3 MYOM2 CD40LG
21 tracheal lymphoma 10.3 SDC1 IGHV4-38-2
22 impetigo 10.3 MYOM2 CD40LG
23 mental retardation, autosomal dominant 36 10.2 SDC1 CD38
24 b-cell expansion with nfkb and t-cell anergy 10.2 CD38 B2M
25 spleen cancer 10.2 IGHV4-38-2 CD40LG
26 schuurs-hoeijmakers syndrome 10.2 IGHV4-38-2 CD40LG
27 spherocytosis, type 5 10.2 SDC1 CD38
28 immunodeficiency with hyper-igm, type 2 10.2 IGHV4-38-2 CD40LG
29 immunodeficiency 43 10.2 B2M ALB
30 orthostatic proteinuria 10.2 B2M ALB
31 viral meningitis 10.1 CD40LG B2M
32 chronic pyelonephritis 10.1 B2M ALB
33 mental retardation, autosomal dominant 33 10.1 IGHV4-38-2 CD38
34 chromosome 13q14 deletion syndrome 10.1 IGHV4-38-2 CD38
35 cork-handlers' disease 10.1 CD40LG ALB
36 fournier gangrene 10.1 CD40LG ALB
37 heterophyiasis 10.1 CD40LG ALB
38 mulchandani-bhoj-conlin syndrome 10.1 CD40LG CD38
39 splenic abscess 10.1 CD40LG ALB
40 meningovascular neurosyphilis 10.1 CD40LG ALB
41 acalculous cholecystitis 10.1 CD40LG ALB
42 gastrointestinal tuberculosis 10.1 CD40LG ALB
43 granulomatous hepatitis 10.1 CD40LG ALB
44 klebsiella pneumonia 10.1 CD40LG ALB
45 necrotizing fasciitis 10.1 MYOM2 ALB
46 anemia, autoimmune hemolytic 10.1 IGHV4-38-2 CD40LG
47 cll/sll 10.1 IGHV4-38-2 CD38
48 subacute bacterial endocarditis 10.1 CD40LG ALB
49 splenic infarction 10.1 CD40LG ALB
50 abdominal tuberculosis 10.1 CD40LG ALB

Graphical network of the top 20 diseases related to Non-Secretory Myeloma:



Diseases related to Non-Secretory Myeloma

Symptoms & Phenotypes for Non-Secretory Myeloma

Drugs & Therapeutics for Non-Secretory Myeloma

Drugs for Non-Secretory Myeloma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
2
Prednisone Approved, Vet_approved Phase 2 53-03-2 5865
3
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 2 1177-87-3
4
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
5
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 5743
6
Bortezomib Approved, Investigational Phase 2 179324-69-7 387447 93860
7
Liposomal doxorubicin Phase 2 31703

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 An Open-label Phase II Study of the Efficacy of Combination Bortezomib-containing Regimens in the Treatment of Newly Diagnosed Patients With t (4; 14) Positive Multiple Myeloma Completed NCT00570180 Phase 2 Bortezomib

Search NIH Clinical Center for Non-Secretory Myeloma

Genetic Tests for Non-Secretory Myeloma

Anatomical Context for Non-Secretory Myeloma

MalaCards organs/tissues related to Non-Secretory Myeloma:

40
Bone, Bone Marrow, Skin, Endothelial

Publications for Non-Secretory Myeloma

Articles related to Non-Secretory Myeloma:

(show top 50) (show all 76)
# Title Authors PMID Year
1
Usefulness of free light chain measurement in monoclonal gammopathy, other haematological malignancies and autoimmune diseases. 61
31418701 2019
2
Laboratory Features of Newly Diagnosed Multiple Myeloma Patients. 61
31355076 2019
3
A Rare Case of Non-Secretory Multiple Myeloma: A Case Report and Literature Review. 61
30881278 2019
4
Successful treatment of central nervous system myeloma manifesting as cauda equina nodules with intrathecal chemotherapy, lenalidomide and dexamethasone. 61
30413447 2018
5
Plasma Cell Myeloma - 20-Year Comparative Survival and Mortality of Three Plasma Cell Myeloma ICD-O-3 Oncologic Phenotypes by Age, Sex, Race, Stage, Cohort Entry Time-Period and Disease Duration: A Systematic Review of 111,041 Cases for Diagnosis Years 1973-2014: (SEER*Stat 8.3.4). 61
30668210 2018
6
Non-Secretory Myeloma: Ready for a new Definition? 61
28894562 2017
7
Non-Secretory Myeloma, Diagnosed on Renal Biopsy as Cast Nephropathy. 61
27504298 2016
8
International Scoring System in Symptomatic Multiple Myeloma: Experience from a Tertiary Care Center. 61
27221891 2016
9
Clinical course and prognosis of non-secretory multiple myeloma. 61
25382589 2015
10
A Rare Variant of Multiple Myeloma; Non-Secretory Myeloma with diffuse osteolytic lesions. 61
26003102 2015
11
Clinical Course and Prognosis of Non-Secretory Multiple Myeloma. 61
25690913 2015
12
Serum-free light-chain assay: clinical utility and limitations. 61
24489083 2014
13
Non-secretory myeloma: one, two, or more entities? 61
24282994 2013
14
Non-secretory myeloma: a clinician's guide. 61
24282993 2013
15
Non-secretory myeloma: clinical and biologic implications. 61
24282995 2013
16
Oligosecretory biclonal multiple myeloma. 61
24133785 2013
17
Myelomagenesis: capturing early microenvironment changes. 61
21232654 2011
18
Polymyositis associated with non-secretory myeloma - a case report. 61
23393512 2011
19
[A case of non-secretory myeloma with crystal-storing histiocytosis]. 61
21157142 2010
20
Efficacy and outcome of autologous transplantation in rare myelomas. 61
20971818 2010
21
Nonsecretory multiple myeloma - a rare case of acute renal failure. 61
20875385 2010
22
Oligo-secretory myeloma in a patient with ankylosing spondylitis. 61
19582458 2010
23
Case report. Non-secretory multiple myeloma presenting with diffuse sclerosis of affected bones interspersed with osteolytic lesions. 61
19168686 2009
24
International Myeloma Working Group guidelines for serum-free light chain analysis in multiple myeloma and related disorders. 61
19020545 2009
25
Non-secretory myeloma: a rare variant of multiple myeloma. 61
18803898 2008
26
[Serum free light chains for diagnosis and follow-up of multiple myeloma]. 61
18594166 2008
27
The evolving use of serum free light chain assays in haematology. 61
18318757 2008
28
[Recommendations for early identification of damage to the skeleton by malignant processes, and for early diagnosis of multiple myeloma]. 61
18175427 2006
29
[Laboratory identification of monoclonal immunoglobin]. 61
18181283 2006
30
Cytodiagnosis of multiple myeloma presenting as orbital involvement: a case report. 61
16901345 2006
31
Serum free light chains for monitoring multiple myeloma. 61
15257706 2004
32
Myeloma with predominant phalangeal involvement. 61
15055321 2004
33
Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: a report of the International Myeloma Working Group. 61
12780789 2003
34
Localized epidural and bone amyloidosis, rare cause of paraplegia in multiple myeloma. 61
12762143 2003
35
Fluoro-deoxyglucose positron emission tomography imaging for the detection of occult disease in multiple myeloma. 61
11918544 2002
36
[Non-secretory myeloma syndrome]. 61
11552309 2001
37
Relapsing polychondritis, smouldering non-secretory myeloma and early myelodysplastic syndrome in the same patient: three difficult diagnoses produce a life threatening illness. 61
10634653 2000
38
Non secretory multiple myeloma involving the maxilla: report of a case with update of biology and new approaches to management. 61
9231172 1997
39
[A case of light chain disease characterized by non-secretory myeloma]. 61
9122004 1996
40
Type III procollagen N-peptide correlates with beta-2-microglobulin in myelomatosis. 61
8719897 1995
41
Plasma cell myeloma in unusually young patients: a report of two cases and review of the literature. 61
7709252 1995
42
[Non-secretory myeloma]. 61
7865669 1994
43
[Initial central nervous system involvement in a case of non-secretory multiple myeloma]. 61
8140502 1993
44
Twelve-year profile of a non-secretory myeloma with amyloidosis. 61
2282322 1990
45
In situ hybridization detection of light chain mRNA in routine bone marrow trephines from patients with suspected myeloma. 61
2513865 1989
46
Hypercalcaemia in a patient with non-secretory myeloma. 61
3211820 1988
47
Skin involvement in non-secretory myeloma. 61
3407670 1988
48
[Light-chain myeloma and non-secretory myeloma--problems in di- agnosis and associated paraproteins]. 61
3141128 1988
49
Non-secretory multiple myeloma: a report of 13 cases with a review of the literature. 61
3549511 1986
50
Non-secretory myeloma. 61
3793705 1986

Variations for Non-Secretory Myeloma

Expression for Non-Secretory Myeloma

Search GEO for disease gene expression data for Non-Secretory Myeloma.

Pathways for Non-Secretory Myeloma

Pathways related to Non-Secretory Myeloma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.5 SDC1 NCAM1 CD40LG
2 11.44 NCAM1 CD40LG CD38 B2M
3 11.2 SDC1 NCAM1 CD38

GO Terms for Non-Secretory Myeloma

Cellular components related to Non-Secretory Myeloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.35 SDC1 NCAM1 CD40LG CD38 B2M
2 external side of plasma membrane GO:0009897 9.02 SDC1 NCAM1 IGHV4-38-2 CD40LG B2M

Biological processes related to Non-Secretory Myeloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 retina homeostasis GO:0001895 8.62 B2M ALB

Sources for Non-Secretory Myeloma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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