MCID: NNS003
MIFTS: 24

Non-Secretory Myeloma

Categories: Blood diseases, Cancer diseases

Aliases & Classifications for Non-Secretory Myeloma

MalaCards integrated aliases for Non-Secretory Myeloma:

Name: Non-Secretory Myeloma 12 15 70

Classifications:



External Ids:

Disease Ontology 12 DOID:9547
SNOMED-CT 67 277580004
UMLS 70 C0456845

Summaries for Non-Secretory Myeloma

MalaCards based summary : Non-Secretory Myeloma is related to amyloid tumor and heavy chain disease. An important gene associated with Non-Secretory Myeloma is MYOM2 (Myomesin 2), and among its related pathways/superpathways are NF-kappaB Signaling and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include bone marrow, kidney and bone.

Related Diseases for Non-Secretory Myeloma

Diseases related to Non-Secretory Myeloma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 93)
# Related Disease Score Top Affiliating Genes
1 amyloid tumor 30.3 MYOM2 B2M
2 heavy chain disease 30.2 MYOM2 IGHV4-38-2
3 proteinuria, chronic benign 30.2 B2M ALB
4 amyloidosis 30.0 MYOM2 B2M ALB
5 plasma cell neoplasm 29.9 SDC1 MYOM2 IGHV4-38-2 B2M
6 acute kidney failure 29.8 B2M ALB
7 plasma cell leukemia 29.6 SDC1 NCAM1 CD38
8 myeloma, multiple 28.9 SDC1 NCAM1 MYOM2 IGHV4-38-2 CD38 B2M
9 monoclonal gammopathy of uncertain significance 28.8 SDC1 NCAM1 MYOM2 IGHV4-38-2 CD38 B2M
10 glomeruloid hemangioma 10.2 SDC1 MYOM2
11 tracheal lymphoma 10.2 SDC1 IGHV4-38-2
12 castleman disease 10.2 SDC1 MYOM2
13 mental retardation, autosomal dominant 36 10.2 SDC1 CD38
14 orthostatic proteinuria 10.1 B2M ALB
15 oxirane allergy 10.1 B2M ALB
16 b-cell expansion with nfkb and t-cell anergy 10.1 CD38 B2M
17 scarlet fever 10.1 MYOM2 ALB
18 spherocytosis, type 5 10.1 SDC1 CD38
19 pyuria 10.1 B2M ALB
20 papilledema 10.1 MYOM2 ALB
21 diamond-blackfan anemia 3 10.1 B2M ALB
22 mulchandani-bhoj-conlin syndrome 10.1 SDC1 CD38
23 mental retardation, autosomal dominant 33 10.1 IGHV4-38-2 CD38
24 immunodeficiency 43 10.1 B2M ALB
25 acute poststreptococcal glomerulonephritis 10.1 MYOM2 ALB
26 chronic pyelonephritis 10.1 B2M ALB
27 chromosome 13q14 deletion syndrome 10.1 IGHV4-38-2 CD38
28 necrotizing fasciitis 10.1 MYOM2 ALB
29 schuurs-hoeijmakers syndrome 10.1 IGHV4-38-2 CD38
30 pleural empyema 10.1 SDC1 ALB
31 multicentric castleman disease 10.1 SDC1 CD38
32 cll/sll 10.1 IGHV4-38-2 CD38
33 richter's syndrome 10.1 IGHV4-38-2 CD38
34 pyelitis 10.1 B2M ALB
35 acute kidney tubular necrosis 10.1 B2M ALB
36 amyloidosis, hereditary, transthyretin-related 10.1 B2M ALB
37 danubian endemic familial nephropathy 10.1 B2M ALB
38 cellulitis 10.1 MYOM2 ALB
39 gastric lymphoma 10.1 IGHV4-38-2 ALB
40 coronavirus infectious disease 10.1 MYOM2 ALB
41 dacryocystocele 10.0 NCAM1 IGHV4-38-2
42 chronic inflammation of lacrimal passage 10.0 NCAM1 IGHV4-38-2
43 diverticulitis 10.0 SDC1 ALB
44 rheumatic fever 10.0 MYOM2 ALB
45 marginal zone b-cell lymphoma 10.0 SDC1 IGHV4-38-2
46 syphilis 10.0 B2M ALB
47 splenic disease 10.0 IGHV4-38-2 ALB
48 meningoencephalitis 10.0 B2M ALB
49 lymphoma, mucosa-associated lymphoid type 10.0 SDC1 IGHV4-38-2 B2M
50 commensal bacterial infectious disease 10.0 MYOM2 ALB

Graphical network of the top 20 diseases related to Non-Secretory Myeloma:



Diseases related to Non-Secretory Myeloma

Symptoms & Phenotypes for Non-Secretory Myeloma

Drugs & Therapeutics for Non-Secretory Myeloma

Search Clinical Trials , NIH Clinical Center for Non-Secretory Myeloma

Genetic Tests for Non-Secretory Myeloma

Anatomical Context for Non-Secretory Myeloma

MalaCards organs/tissues related to Non-Secretory Myeloma:

40
Bone Marrow, Kidney, Bone, Endothelial, Myeloid

Publications for Non-Secretory Myeloma

Articles related to Non-Secretory Myeloma:

(show top 50) (show all 77)
# Title Authors PMID Year
1
Autologous Bone Marrow Transplant in Multiple Myeloma Patient With Bone Marrow Hematopoietic Stem Cell. 61
33377884 2020
2
[Usefulness of free light chain measurement in monoclonal gammopathy, other haematological malignancies and autoimmune diseases]. 61
31418701 2019
3
Laboratory Features of Newly Diagnosed Multiple Myeloma Patients. 61
31355076 2019
4
A Rare Case of Non-Secretory Multiple Myeloma: A Case Report and Literature Review. 61
30881278 2019
5
Successful treatment of central nervous system myeloma manifesting as cauda equina nodules with intrathecal chemotherapy, lenalidomide and dexamethasone. 61
30413447 2018
6
Plasma Cell Myeloma - 20-Year Comparative Survival and Mortality of Three Plasma Cell Myeloma ICD-O-3 Oncologic Phenotypes by Age, Sex, Race, Stage, Cohort Entry Time-Period and Disease Duration: A Systematic Review of 111,041 Cases for Diagnosis Years 1973-2014: (SEER*Stat 8.3.4). 61
30668210 2018
7
Non-Secretory Myeloma: Ready for a new Definition? 61
28894562 2017
8
Non-Secretory Myeloma, Diagnosed on Renal Biopsy as Cast Nephropathy. 61
27504298 2016
9
International Scoring System in Symptomatic Multiple Myeloma: Experience from a Tertiary Care Center. 61
27221891 2016
10
Clinical course and prognosis of non-secretory multiple myeloma. 61
25382589 2015
11
A Rare Variant of Multiple Myeloma; Non-Secretory Myeloma with diffuse osteolytic lesions. 61
26003102 2015
12
Clinical Course and Prognosis of Non-Secretory Multiple Myeloma. 61
25690913 2015
13
Serum-free light-chain assay: clinical utility and limitations. 61
24489083 2014
14
Non-secretory myeloma: a clinician's guide. 61
24282993 2013
15
Non-secretory myeloma: one, two, or more entities? 61
24282994 2013
16
Non-secretory myeloma: clinical and biologic implications. 61
24282995 2013
17
Oligosecretory biclonal multiple myeloma. 61
24133785 2013
18
Polymyositis associated with non-secretory myeloma - a case report. 61
23393512 2011
19
Myelomagenesis: capturing early microenvironment changes. 61
21232654 2011
20
[A case of non-secretory myeloma with crystal-storing histiocytosis]. 61
21157142 2010
21
Efficacy and outcome of autologous transplantation in rare myelomas. 61
20971818 2010
22
Nonsecretory multiple myeloma - a rare case of acute renal failure. 61
20875385 2010
23
Oligo-secretory myeloma in a patient with ankylosing spondylitis. 61
19582458 2010
24
Case report. Non-secretory multiple myeloma presenting with diffuse sclerosis of affected bones interspersed with osteolytic lesions. 61
19168686 2009
25
International Myeloma Working Group guidelines for serum-free light chain analysis in multiple myeloma and related disorders. 61
19020545 2009
26
Non-secretory myeloma: a rare variant of multiple myeloma. 61
18803898 2008
27
[Serum free light chains for diagnosis and follow-up of multiple myeloma]. 61
18594166 2008
28
The evolving use of serum free light chain assays in haematology. 61
18318757 2008
29
[Recommendations for early identification of damage to the skeleton by malignant processes, and for early diagnosis of multiple myeloma]. 61
18175427 2006
30
[Laboratory identification of monoclonal immunoglobin]. 61
18181283 2006
31
Cytodiagnosis of multiple myeloma presenting as orbital involvement: a case report. 61
16901345 2006
32
Serum free light chains for monitoring multiple myeloma. 61
15257706 2004
33
Myeloma with predominant phalangeal involvement. 61
15055321 2004
34
Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: a report of the International Myeloma Working Group. 61
12780789 2003
35
Localized epidural and bone amyloidosis, rare cause of paraplegia in multiple myeloma. 61
12762143 2003
36
Fluoro-deoxyglucose positron emission tomography imaging for the detection of occult disease in multiple myeloma. 61
11918544 2002
37
[Non-secretory myeloma syndrome]. 61
11552309 2001
38
Relapsing polychondritis, smouldering non-secretory myeloma and early myelodysplastic syndrome in the same patient: three difficult diagnoses produce a life threatening illness. 61
10634653 2000
39
Non secretory multiple myeloma involving the maxilla: report of a case with update of biology and new approaches to management. 61
9231172 1997
40
[A case of light chain disease characterized by non-secretory myeloma]. 61
9122004 1996
41
Type III procollagen N-peptide correlates with beta-2-microglobulin in myelomatosis. 61
8719897 1995
42
Plasma cell myeloma in unusually young patients: a report of two cases and review of the literature. 61
7709252 1995
43
[Non-secretory myeloma]. 61
7865669 1994
44
[Initial central nervous system involvement in a case of non-secretory multiple myeloma]. 61
8140502 1993
45
Twelve-year profile of a non-secretory myeloma with amyloidosis. 61
2282322 1990
46
In situ hybridization detection of light chain mRNA in routine bone marrow trephines from patients with suspected myeloma. 61
2513865 1989
47
Hypercalcaemia in a patient with non-secretory myeloma. 61
3211820 1988
48
Skin involvement in non-secretory myeloma. 61
3407670 1988
49
[Light-chain myeloma and non-secretory myeloma--problems in di- agnosis and associated paraproteins]. 61
3141128 1988
50
Non-secretory multiple myeloma: a report of 13 cases with a review of the literature. 61
3549511 1986

Variations for Non-Secretory Myeloma

Expression for Non-Secretory Myeloma

Search GEO for disease gene expression data for Non-Secretory Myeloma.

Pathways for Non-Secretory Myeloma

Pathways related to Non-Secretory Myeloma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.65 NCAM1 CD38 B2M
2 10.86 SDC1 NCAM1 CD38

GO Terms for Non-Secretory Myeloma

Cellular components related to Non-Secretory Myeloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.26 SDC1 NCAM1 CD38 B2M
2 external side of plasma membrane GO:0009897 8.92 SDC1 NCAM1 IGHV4-38-2 B2M

Biological processes related to Non-Secretory Myeloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 retina homeostasis GO:0001895 8.62 B2M ALB

Molecular functions related to Non-Secretory Myeloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.02 SDC1 NCAM1 CD38 B2M ALB

Sources for Non-Secretory Myeloma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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