MCID: NNS006
MIFTS: 28

Non-Suppurative Otitis Media

Categories: Ear diseases

Aliases & Classifications for Non-Suppurative Otitis Media

MalaCards integrated aliases for Non-Suppurative Otitis Media:

Name: Non-Suppurative Otitis Media 12 15 74
Nonsuppurative Otitis Media 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11180
ICD9CM 36 381.4
SNOMED-CT 69 45935001
ICD10 34 H65 H65.9 H65.90
UMLS 74 C0271446

Summaries for Non-Suppurative Otitis Media

Disease Ontology : 12 A otitis media which involves transudation of fluid in the middle ear without pus formation.

MalaCards based summary : Non-Suppurative Otitis Media, also known as nonsuppurative otitis media, is related to acute serous otitis media and serous glue ear. An important gene associated with Non-Suppurative Otitis Media is GJA8 (Gap Junction Protein Alpha 8), and among its related pathways/superpathways are Th2 Differentiation Pathway and Inflammatory Response Pathway. The drugs Antibiotics, Antitubercular and Anti-Infective Agents have been mentioned in the context of this disorder.

Related Diseases for Non-Suppurative Otitis Media

Diseases related to Non-Suppurative Otitis Media via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 62)
# Related Disease Score Top Affiliating Genes
1 acute serous otitis media 11.6
2 serous glue ear 11.5
3 eustachian tube disease 11.5
4 otitis media 10.5
5 suppurative otitis media 10.5
6 cercarial dermatitis 10.2 CTSB IL5
7 myasthenia gravis 10.1
8 cholesteatoma of middle ear 10.1
9 chronic purulent otitis media 10.1
10 myasthenia gravis congenital 10.1
11 anterior scleritis 10.1 IL5 PRTN3
12 granulomatous angiitis 10.1 IL5 PRTN3
13 nickel allergic contact dermatitis 10.1 IL4 IL5
14 allergic contact dermatitis 10.1 IL4 IL5
15 contact dermatitis 10.1 IL4 IL5
16 cough variant asthma 10.1 IL4 IL5
17 scleritis 10.1 IL4 IL5
18 egg allergy 10.0 IL4 IL5
19 inflammatory bowel disease 4 10.0 IL4 IL5
20 sulfamethoxazole allergy 10.0 IL4 IL5
21 atopic keratoconjunctivitis 10.0 IL4 IL5
22 keratoconjunctivitis 10.0 IL4 IL5
23 conjunctivitis 10.0 IL4 IL5
24 angiostrongyliasis 10.0 IL4 IL5
25 intrinsic asthma 10.0 IL4 IL5
26 trichinosis 10.0 IL4 IL5
27 churg-strauss syndrome 10.0 IL5 PRTN3
28 apple allergy 10.0 IL4 IL5
29 gaucher disease, type ii 10.0 IL4 IL5
30 latex allergy 10.0 IL4 IL5
31 eosinophilic meningitis 10.0 IL4 IL5
32 intestinal schistosomiasis 10.0 IL4 IL5
33 chronic tic disorder 10.0 IL4 IL5
34 filarial elephantiasis 10.0 IL4 IL5
35 chronic conjunctivitis 10.0 IL4 IL5
36 eosinophilic gastritis 10.0 IL4 IL5
37 kimura disease 10.0 IL4 IL5
38 vernal keratoconjunctivitis 10.0 IL4 IL5
39 toxic oil syndrome 10.0 IL4 IL5
40 urinary schistosomiasis 10.0 IL4 IL5
41 folliculitis 10.0 IL4 IL5
42 enterobiasis 10.0 IL4 IL5
43 conjunctival disease 10.0 IL4 IL5
44 allergic bronchopulmonary aspergillosis 10.0 IL4 IL5
45 milk allergy 10.0 IL4 IL5
46 pulmonary eosinophilia 10.0 IL4 IL5
47 paranasal sinus disease 10.0 IL4 IL5
48 onchocerciasis 10.0 IL4 IL5
49 allergic conjunctivitis 10.0 IL4 IL5
50 nasal cavity disease 10.0 IL4 IL5

Graphical network of the top 20 diseases related to Non-Suppurative Otitis Media:



Diseases related to Non-Suppurative Otitis Media

Symptoms & Phenotypes for Non-Suppurative Otitis Media

Drugs & Therapeutics for Non-Suppurative Otitis Media

Drugs for Non-Suppurative Otitis Media (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antibiotics, Antitubercular
2 Anti-Infective Agents
3 Anti-Bacterial Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Microbiome Variability and Antibiotic Resistance of Chronic Suppurative Otitis Not yet recruiting NCT03456739

Search NIH Clinical Center for Non-Suppurative Otitis Media

Genetic Tests for Non-Suppurative Otitis Media

Anatomical Context for Non-Suppurative Otitis Media

Publications for Non-Suppurative Otitis Media

Articles related to Non-Suppurative Otitis Media:

(show all 14)
# Title Authors Year
1
Investigation of the presence of biofilms in chronic suppurative otitis media, nonsuppurative otitis media, and chronic otitis media with cholesteatoma by scanning electron microscopy. ( 24288500 )
2013
2
Non-suppurative otitis media. ( 3235847 )
1988
3
The long-term outcome of nonsuppurative otitis media with effusion. ( 3884218 )
1985
4
Ventilating tubes are the treatment of choice for chronic nonsuppurative otitis media. ( 6539079 )
1984
5
Focus: nonsuppurative otitis media. ( 6557450 )
1983
6
Chronic nonsuppurative otitis media. Comparison of tympanostomy tubes and medication versus ventilation. ( 7316374 )
1981
7
Non-suppurative otitis media in children. (A retrospective study of 100 cases). ( 429896 )
1979
8
Analysis of suppurative otitis media in children: aetiology of non-suppurative otitis media. ( 1152752 )
1975
9
Etiologic factors in non-suppurative otitis media. ( 1195971 )
1975
10
Surface tension lowering substance of the Eustachian tube in non-suppurative otitis media: an experiment with dogs. ( 4686674 )
1973
11
Nonsuppurative otitis media in myasthenia gravis. ( 4621254 )
1972
12
Nonsuppurative otitis media. ( 5903464 )
1966
13
Nonsuppurative otitis media--a disease primarily of children. ( 14450878 )
1962
14
Posttonsillectomy and adenectomy deafness in children caused by nonsuppurative otitis media. ( 13543167 )
1958

Variations for Non-Suppurative Otitis Media

Expression for Non-Suppurative Otitis Media

Search GEO for disease gene expression data for Non-Suppurative Otitis Media.

Pathways for Non-Suppurative Otitis Media

Pathways related to Non-Suppurative Otitis Media according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.03 IL4 IL5
2 10.84 IL4 IL5
3 10.76 IL4 IL5
4 10.71 FKBP4 IL4 IL5
5 10.62 IL4 IL5
6 10.37 IL4 IL5

GO Terms for Non-Suppurative Otitis Media

Biological processes related to Non-Suppurative Otitis Media according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.33 IL4 IL5 PRTN3
2 positive regulation of B cell proliferation GO:0030890 8.96 IL4 IL5
3 collagen catabolic process GO:0030574 8.62 CTSB PRTN3

Molecular functions related to Non-Suppurative Otitis Media according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 carbonate dehydratase activity GO:0004089 8.62 CA10 CA8

Sources for Non-Suppurative Otitis Media

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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