MCID: NNS006
MIFTS: 28

Non-Suppurative Otitis Media

Categories: Ear diseases

Aliases & Classifications for Non-Suppurative Otitis Media

MalaCards integrated aliases for Non-Suppurative Otitis Media:

Name: Non-Suppurative Otitis Media 12 15 74
Nonsuppurative Otitis Media 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11180
ICD9CM 36 381.4
SNOMED-CT 69 45935001
ICD10 34 H65 H65.9 H65.90
UMLS 74 C0271446

Summaries for Non-Suppurative Otitis Media

Disease Ontology : 12 A otitis media which involves transudation of fluid in the middle ear without pus formation.

MalaCards based summary : Non-Suppurative Otitis Media, also known as nonsuppurative otitis media, is related to acute serous otitis media and serous glue ear. An important gene associated with Non-Suppurative Otitis Media is GJA8 (Gap Junction Protein Alpha 8), and among its related pathways/superpathways are Th2 Differentiation Pathway and Inflammatory Response Pathway. The drugs Anti-Bacterial Agents and Anti-Infective Agents have been mentioned in the context of this disorder.

Related Diseases for Non-Suppurative Otitis Media

Diseases related to Non-Suppurative Otitis Media via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 60)
# Related Disease Score Top Affiliating Genes
1 acute serous otitis media 11.6
2 serous glue ear 11.5
3 eustachian tube disease 11.5
4 otitis media 10.5
5 suppurative otitis media 10.5
6 cercarial dermatitis 10.2 CTSB IL5
7 myasthenia gravis 10.1
8 myasthenia gravis congenital 10.1
9 anterior scleritis 10.1 IL5 PRTN3
10 granulomatous angiitis 10.1 IL5 PRTN3
11 nickel allergic contact dermatitis 10.1 IL4 IL5
12 allergic contact dermatitis 10.1 IL4 IL5
13 contact dermatitis 10.1 IL4 IL5
14 cough variant asthma 10.0 IL4 IL5
15 scleritis 10.0 IL4 IL5
16 egg allergy 10.0 IL4 IL5
17 inflammatory bowel disease 4 10.0 IL4 IL5
18 sulfamethoxazole allergy 10.0 IL4 IL5
19 atopic keratoconjunctivitis 10.0 IL4 IL5
20 keratoconjunctivitis 10.0 IL4 IL5
21 conjunctivitis 10.0 IL4 IL5
22 angiostrongyliasis 10.0 IL4 IL5
23 intrinsic asthma 10.0 IL4 IL5
24 trichinosis 10.0 IL4 IL5
25 churg-strauss syndrome 10.0 IL5 PRTN3
26 apple allergy 10.0 IL4 IL5
27 gaucher disease, type ii 10.0 IL4 IL5
28 latex allergy 10.0 IL4 IL5
29 eosinophilic meningitis 10.0 IL4 IL5
30 intestinal schistosomiasis 10.0 IL4 IL5
31 chronic tic disorder 10.0 IL4 IL5
32 filarial elephantiasis 10.0 IL4 IL5
33 chronic conjunctivitis 10.0 IL4 IL5
34 eosinophilic gastritis 10.0 IL4 IL5
35 kimura disease 10.0 IL4 IL5
36 vernal keratoconjunctivitis 10.0 IL4 IL5
37 toxic oil syndrome 10.0 IL4 IL5
38 urinary schistosomiasis 10.0 IL4 IL5
39 folliculitis 10.0 IL4 IL5
40 enterobiasis 10.0 IL4 IL5
41 conjunctival disease 10.0 IL4 IL5
42 allergic bronchopulmonary aspergillosis 10.0 IL4 IL5
43 milk allergy 10.0 IL4 IL5
44 pulmonary eosinophilia 10.0 IL4 IL5
45 paranasal sinus disease 10.0 IL4 IL5
46 onchocerciasis 10.0 IL4 IL5
47 allergic conjunctivitis 10.0 IL4 IL5
48 nasal cavity disease 9.9 IL4 IL5
49 paracoccidioidomycosis 9.9 IL4 IL5
50 yellow fever 9.9 IL4 IL5

Graphical network of the top 20 diseases related to Non-Suppurative Otitis Media:



Diseases related to Non-Suppurative Otitis Media

Symptoms & Phenotypes for Non-Suppurative Otitis Media

Drugs & Therapeutics for Non-Suppurative Otitis Media

Drugs for Non-Suppurative Otitis Media (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Anti-Bacterial Agents
2 Anti-Infective Agents
3 Antibiotics, Antitubercular

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Microbiome Variability and Antibiotic Resistance of Chronic Suppurative Otitis Not yet recruiting NCT03456739

Search NIH Clinical Center for Non-Suppurative Otitis Media

Genetic Tests for Non-Suppurative Otitis Media

Anatomical Context for Non-Suppurative Otitis Media

Publications for Non-Suppurative Otitis Media

Articles related to Non-Suppurative Otitis Media:

(show all 13)
# Title Authors Year
1
Non-suppurative otitis media. ( 3235847 )
1988
2
The long-term outcome of nonsuppurative otitis media with effusion. ( 3884218 )
1985
3
Ventilating tubes are the treatment of choice for chronic nonsuppurative otitis media. ( 6539079 )
1984
4
Focus: nonsuppurative otitis media. ( 6557450 )
1983
5
Chronic nonsuppurative otitis media. Comparison of tympanostomy tubes and medication versus ventilation. ( 7316374 )
1981
6
Non-suppurative otitis media in children. (A retrospective study of 100 cases). ( 429896 )
1979
7
Analysis of suppurative otitis media in children: aetiology of non-suppurative otitis media. ( 1152752 )
1975
8
Etiologic factors in non-suppurative otitis media. ( 1195971 )
1975
9
Surface tension lowering substance of the Eustachian tube in non-suppurative otitis media: an experiment with dogs. ( 4686674 )
1973
10
Nonsuppurative otitis media in myasthenia gravis. ( 4621254 )
1972
11
Nonsuppurative otitis media. ( 5903464 )
1966
12
Nonsuppurative otitis media--a disease primarily of children. ( 14450878 )
1962
13
Posttonsillectomy and adenectomy deafness in children caused by nonsuppurative otitis media. ( 13543167 )
1958

Variations for Non-Suppurative Otitis Media

Expression for Non-Suppurative Otitis Media

Search GEO for disease gene expression data for Non-Suppurative Otitis Media.

Pathways for Non-Suppurative Otitis Media

Pathways related to Non-Suppurative Otitis Media according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.03 IL4 IL5
2 10.84 IL4 IL5
3 10.76 IL4 IL5
4 10.71 FKBP4 IL4 IL5
5 10.62 IL4 IL5
6 10.37 IL4 IL5

GO Terms for Non-Suppurative Otitis Media

Biological processes related to Non-Suppurative Otitis Media according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.33 PRTN3 IL5 IL4
2 positive regulation of B cell proliferation GO:0030890 8.96 IL5 IL4
3 collagen catabolic process GO:0030574 8.62 PRTN3 CTSB

Molecular functions related to Non-Suppurative Otitis Media according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 carbonate dehydratase activity GO:0004089 8.62 CA8 CA10

Sources for Non-Suppurative Otitis Media

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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