MCID: NNR004
MIFTS: 58

Nonarteritic Anterior Ischemic Optic Neuropathy

Categories: Genetic diseases, Rare diseases, Neuronal diseases, Eye diseases

Aliases & Classifications for Nonarteritic Anterior Ischemic Optic Neuropathy

MalaCards integrated aliases for Nonarteritic Anterior Ischemic Optic Neuropathy:

Name: Nonarteritic Anterior Ischemic Optic Neuropathy 57 12 29 73
Anterior Ischemic Optic Neuropathy 12 53 75 15 73
Nonarteritic Anterior Ischemic Optic Neuropathy, Susceptibility to 57 29 13 6
Non-Arteritic Anterior Ischemic Optic Neuropathy 12 75 15
Naion 57 75 55
Optic Neuropathy, Ischemic 44 73
Ischemic Optic Neuropathy 12 53
Aion 53 75
Neuropathy, Optic, Ischemic, Nonarteritic Anterior, Susceptibility to 40
Optic Neuropathy, Anterior Ischemic, Susceptibility to 57
Optic Neuropathy, Anterior Ischemic 57
Naion, Susceptibility to 57

Characteristics:

OMIM:

57
Inheritance:
autosomal recessive


HPO:

32
nonarteritic anterior ischemic optic neuropathy:
Inheritance autosomal recessive inheritance


Classifications:



External Ids:

OMIM 57 258660
Disease Ontology 12 DOID:0050864 DOID:12010
ICD10 33 H47.01
ICD9CM 35 377.41
MeSH 44 D018917
SNOMED-CT 68 14357004
MedGen 42 C1847711
SNOMED-CT via HPO 69 258211005

Summaries for Nonarteritic Anterior Ischemic Optic Neuropathy

NIH Rare Diseases : 53 Anterior ischemic optic neuropathy (AION) is an eye disease characterized by infarction of the optic disk leading to vision loss. It can be nonarteritic (nonarteritic anterior ischemic optic neuropathy or NAION) or arteritic, the latter being associated with giant cell arteritis (GCA; often termed temporal arteritis).Vision loss with both varieties is typically rapid (over minutes, hours, or days) and painless. Symptoms such as a general feeling of being unwell (malaise), muscle aches and pains, headaches over the temple, pain when combing hair, pain in the jaw after chewing, and tenderness over the temporal artery (one of the major arteries of the head) may be present with giant cell arteritis. At exam, visual acuity is reduced and the optic disc is swollen. In both subtypes, visual field examination is often reduced in the inferior and central visual fields.The visual loss is usually permanent, with some recovery possibly occurring within the first weeks or months. The arteritic variety is treated with corticosteroids. Treatment of the nonarteritic variety with aspirin or corticosteroids has not been helpful. 

MalaCards based summary : Nonarteritic Anterior Ischemic Optic Neuropathy, also known as anterior ischemic optic neuropathy, is related to arteritic anterior ischemic optic neuropathy and impotence. An important gene associated with Nonarteritic Anterior Ischemic Optic Neuropathy is GP1BA (Glycoprotein Ib Platelet Subunit Alpha), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Complement and coagulation cascades. The drugs Carbidopa and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include eye, endothelial and neutrophil, and related phenotypes are nonarteritic anterior ischemic optic neuropathy and homeostasis/metabolism

UniProtKB/Swiss-Prot : 75 Non-arteritic anterior ischemic optic neuropathy: An ocular disease due to ischemic injury to the optic nerve. It usually affects the optic disk and leads to visual loss and optic disk swelling of a pallid nature. Visual loss is usually sudden, or over a few days at most and is usually permanent, with some recovery possibly occurring within the first weeks or months. Patients with small disks having smaller or non-existent cups have an anatomical predisposition for non-arteritic anterior ischemic optic neuropathy. As an ischemic episode evolves, the swelling compromises circulation, with a spiral of ischemia resulting in further neuronal damage.

Wikipedia : 76 Anterior ischemic optic neuropathy (AION) is a medical condition involving loss of vision caused by... more...

Description from OMIM: 258660

Related Diseases for Nonarteritic Anterior Ischemic Optic Neuropathy

Diseases related to Nonarteritic Anterior Ischemic Optic Neuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 194)
# Related Disease Score Top Affiliating Genes
1 arteritic anterior ischemic optic neuropathy 31.0 ACE F2 F5 GP1BA MTHFR NOS3
2 impotence 30.5 EDN1 NOS3 PDE5A
3 sleep apnea 30.5 ACE EDN1 NOS3
4 retinal artery occlusion 29.4 F2 F5 MTHFR SERPINC1
5 antiphospholipid syndrome 29.4 F2 F5 MTHFR SERPINC1
6 thrombophilia 29.4 F2 F5 MTHFR SERPINC1
7 central retinal vein occlusion 29.2 F2 F5 MTHFR SERPINC1
8 retinal vein occlusion 29.2 F2 F5 MTHFR SERPINC1
9 diabetes mellitus 28.6 ACE AGTR1 EDN1 NOS3
10 pulmonary hypertension 28.4 ACE EDN1 NOS3 PDE5A SERPINC1
11 ischemic optic neuropathy 25.9 ACE AGTR1 EDN1 F2 F5 GP1BA
12 optic nerve disease 11.2
13 neuropathy 11.2
14 inferior vena cava interruption 10.7 F5 MTHFR
15 amaurosis fugax 10.7 F5 MTHFR
16 cerebral atherosclerosis 10.7 ACE MTHFR
17 catastrophic antiphospholipid syndrome 10.6 F5 MTHFR
18 retinitis 10.6
19 hemifacial spasm 10.5 MTHFR NOS3
20 renal artery obstruction 10.5 ACE SERPINC1
21 coronary restenosis 10.4 ACE SERPINC1
22 sticky platelet syndrome 10.4 F5 SERPINC1
23 idiopathic edema 10.4 ACE EDN1
24 choroiditis 10.4
25 coronary thrombosis 10.4 GP1BA SERPINC1
26 pure autonomic failure 10.4 ACE PDE5A
27 mesenteric vascular occlusion 10.4 F2 MTHFR
28 hepatoportal sclerosis 10.4 ACE F2
29 ischemic neuropathy 10.4 F2 MTHFR
30 optic neuritis 10.4
31 neuritis 10.4
32 meningococcemia 10.3 F5 SERPINC1
33 paracetamol poisoning 10.3 F2 F5
34 diabetic angiopathy 10.3 EDN1 MTHFR
35 carotid artery occlusion 10.3 F5 NOS3
36 cerebral sinovenous thrombosis 10.3 F2 F5
37 coronary artery vasospasm 10.3 EDN1 NOS3
38 intermediate coronary syndrome 10.3 ACE SERPINC1
39 hemoglobin e disease 10.3 F2 F5
40 apnea, obstructive sleep 10.3
41 chronic mountain sickness 10.3 EDN1 NOS3
42 legg-calve-perthes disease 10.3 F5 SERPINC1
43 factor xii deficiency 10.3 F5 SERPINC1
44 factor viii deficiency 10.3 F2 F5
45 schizencephaly 10.2 F5 MTHFR
46 acute chest syndrome 10.2 EDN1 NOS3
47 chronic thromboembolic pulmonary hypertension 10.2 EDN1 F2
48 aging 10.2
49 cataract 10.2
50 open-angle glaucoma 10.2

Comorbidity relations with Nonarteritic Anterior Ischemic Optic Neuropathy via Phenotypic Disease Network (PDN):


Hypertension, Essential Temporal Arteritis

Graphical network of the top 20 diseases related to Nonarteritic Anterior Ischemic Optic Neuropathy:



Diseases related to Nonarteritic Anterior Ischemic Optic Neuropathy

Symptoms & Phenotypes for Nonarteritic Anterior Ischemic Optic Neuropathy

Symptoms via clinical synopsis from OMIM:

57
Eyes:
nonarteritic anterior ischemic optic neuropathy
papillophlebitis


Clinical features from OMIM:

258660

Human phenotypes related to Nonarteritic Anterior Ischemic Optic Neuropathy:

32
# Description HPO Frequency HPO Source Accession
1 nonarteritic anterior ischemic optic neuropathy 32 HP:0007634

MGI Mouse Phenotypes related to Nonarteritic Anterior Ischemic Optic Neuropathy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.91 ACE AGTR1 EDN1 F2 F5 GP1BA
2 cardiovascular system MP:0005385 9.87 F5 NOS3 SERPINC1 ACE AGTR1 EDN1
3 mortality/aging MP:0010768 9.76 ACE AGTR1 EDN1 F2 F5 MTHFR
4 nervous system MP:0003631 9.5 AGTR1 EDN1 F2 F5 MTHFR NOS3
5 renal/urinary system MP:0005367 9.02 ACE AGTR1 EDN1 NOS3 SERPINC1

Drugs & Therapeutics for Nonarteritic Anterior Ischemic Optic Neuropathy

Drugs for Nonarteritic Anterior Ischemic Optic Neuropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 100)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Carbidopa Approved Phase 4 28860-95-9 34359 38101
2
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
3
Levodopa Approved Phase 4 59-92-7 6047
4
4-Aminopyridine Approved Phase 4 504-24-5 1727
5
Ephedrine Approved Phase 4 299-42-3 9294
6
Pseudoephedrine Approved Phase 4 90-82-4 7028
7
Tadalafil Approved, Investigational Phase 4 171596-29-5 110635
8
Choline Approved, Nutraceutical Phase 4,Not Applicable 62-49-7 305
9 Autonomic Agents Phase 4,Phase 3,Phase 2
10 Gastrointestinal Agents Phase 4,Phase 3
11 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Not Applicable
12 Cytidine Diphosphate Choline Phase 4,Not Applicable
13 Nootropic Agents Phase 4,Not Applicable
14 Adjuvants, Immunologic Phase 4
15 Antiparkinson Agents Phase 4
16 Aromatic Amino Acid Decarboxylase Inhibitors Phase 4
17 Carbidopa, levodopa drug combination Phase 4
18 Dopamine Agents Phase 4
19 Dopamine agonists Phase 4
20 Neurotransmitter Agents Phase 4,Phase 1
21 Potassium Channel Blockers Phase 4
22 Phosphodiesterase 5 Inhibitors Phase 4
23 Phosphodiesterase Inhibitors Phase 4,Phase 2
24 Adrenergic Agents Phase 4,Phase 1
25 Adrenergic Agonists Phase 4
26 Adrenergic alpha-2 Receptor Agonists Phase 4
27 Adrenergic alpha-Agonists Phase 4
28 Antihypertensive Agents Phase 4,Phase 3,Phase 1
29 Brimonidine Tartrate Phase 4 70359-46-5
30 Carboxymethylcellulose Sodium Phase 4
31 Cathartics Phase 4
32 Laxatives Phase 4
33 Nasal Decongestants Phase 4
34 Ophthalmic Solutions Phase 4
35 Pharmaceutical Solutions Phase 4,Not Applicable
36 Respiratory System Agents Phase 4
37 Tetrahydrozoline Phase 4
38 Vasoconstrictor Agents Phase 4
39 Sildenafil Citrate Phase 4 171599-83-0
40 Vardenafil Dihydrochloride Phase 4
41
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
42
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
43
Triamcinolone Approved, Vet_approved Phase 3,Phase 1,Phase 2 124-94-7 31307
44
Bosentan Approved, Investigational Phase 3 147536-97-8 104865
45 Antiemetics Phase 3
46 Anti-Inflammatory Agents Phase 3,Phase 1,Phase 2,Not Applicable
47 Antineoplastic Agents, Hormonal Phase 3
48 glucocorticoids Phase 3,Phase 1,Phase 2
49 Hormone Antagonists Phase 3,Phase 1,Phase 2
50 Hormones Phase 3,Phase 1,Phase 2

Interventional clinical trials:

(show all 47)
# Name Status NCT ID Phase Drugs
1 Citicoline Effect on Non-arteritic Anterior Ischemic Optic Neuropathy (NAION) Completed NCT03046693 Phase 4 Group A Citicoline 1000 mg oral tablet;Group B placebo oral tablet
2 Effect of Levodopa-Carbidopa on Visual Function in Patients With Recent-Onset Nonarteritic Anterior Ischemic Optic Neuropathy Completed NCT00432393 Phase 4 levodopa-carbidopa
3 A New Medicine to Treat Nonarteritic Anterior Ischemic Optic Neuropathy (NAION) Completed NCT01975324 Phase 4 dalfampridine;Placebo
4 Neural Conduction Along the Visual Pathways After Oral Treatment With Citicoline in Patients With Optic Nerve Diseases Completed NCT00404729 Phase 4 Cytidine-5’-diphosphocholine (Citicoline)
5 Preoperative Brimonidine on IOP of Patients Undergoing RALP Recruiting NCT02818816 Phase 4 brimonidine tartrate 0.2%
6 PDE5 Inhibitor Use and Non-arteritic Anterior Ischemic Optic Neuropathy (NAION) Terminated NCT00867815 Phase 4 Diagnostic procedures
7 Outcomes of Steroid and Oxygen Therapy Versus Placebo Therapy in Non-arteritic Anterior Ischemic Optic Neuropathy Unknown status NCT02439866 Phase 3 placebo;Intravenous methylprednisolone;normobaric oxygen with face mask
8 Retrobulbar Triamcinolone Acetonide Injection in the Treatment of NA-AION Unknown status NCT02329288 Phase 3 Triamcinolone Acetonide;placebo
9 Ischemic Optic Neuropathy Decompression Trial (IONDT) Completed NCT00000127 Phase 3
10 Phase 2/3, Randomized, Double-Masked, Sham-Controlled Trial of QPI-1007 in Subjects With Acute Nonarteritic Anterior Ischemic Optic Neuropathy (NAION) Recruiting NCT02341560 Phase 2, Phase 3 QPI-1007 Injection - 1.5 mg;QPI-1007 Injection - 3.0 mg
11 ENDOTHELION Study Group: Effect of Bosentan in NAION Patients Recruiting NCT02377271 Phase 3 bosentan;placebo
12 Erythropoietin in Methanol Associated Optic Neuropathy: A Phase-2 Clinical Trial (EPO-MAON Study) Recruiting NCT02376881 Phase 3 Erythropoietin
13 Efficacy & Safety of RPh201 Treatment in Patients With Previous Nonarteritic Anterior Ischemic Optic Neuropathy (NAION) Not yet recruiting NCT03547206 Phase 3 RPh201
14 Comparison of Intravitreal Bevacizumab and Triamcinolone With Placebo Unknown status NCT01330524 Phase 1, Phase 2 Avastin and Triamcinolone
15 Intravitreal Bevacizumab for Non-Arteritic Anterior Ischemic Optic Neuropathy Unknown status NCT00813059 Phase 2 Intra-vitreal injection of bevacizumab (1.25mg/0.05ml)
16 Neurotomy of Optic Nerve in Non-Arthritic Anterior Ischemic Optic Neuropathy Completed NCT00372021 Phase 1, Phase 2
17 Safety and Efficacy Study of RPh201 Treatment of Ischemic Optic Neuropathy (ION). Completed NCT02045212 Phase 2 RPh201;Placebo
18 Effects of Moxaverine and Placebo on Ocular Blood Flow Completed NCT00709423 Phase 2 Moxaverine;Moxaverin 150mg;NaCl
19 Safety Assessment of Intravitreal Mesenchymal Stem Cells for Acute Non Arteritic Anterior Ischemic Optic Neuropathy Not yet recruiting NCT03173638 Phase 2
20 A Phase I Clinical Trial of DARC Unknown status NCT02394613 Phase 1 ANX776
21 Safety Study of a Single IVT Injection of QPI-1007 in Chronic Optic Nerve Atrophy and Recent Onset NAION Patients Completed NCT01064505 Phase 1 QPI-1007 at various doses
22 Ranibizumab Therapy for Non-arteritic Ischemic Optic Neuropathy Completed NCT00561834 Phase 1 ranibizumab
23 NT-501 CNTF Implant for Ischemic Optic Neuropathy: Safety, Neuroprotection and Neuroenhancement Completed NCT01411657 Phase 1 NT-501 CNTF Implant
24 Treatment Study for Ischemic Optic Neuropathy With Opthalmic Timolol Maleate 0.5% Withdrawn NCT01607671 Phase 1 Timolol maleate
25 Ischemic Optic Neuropathy Decompression Trial Followup (IONDT Followup) Unknown status NCT00000126
26 Study of Ocular Blood Flow in Patients With Glaucoma and/or Obstructive Sleep Apnea Syndrome (OSAS) Unknown status NCT00874913 Not Applicable
27 Vision Restoration Therapy (VRT) to Treat Non-Arteritic Anterior Ischemic Optic Neuropathy Completed NCT00140491 Not Applicable
28 A Study to Determine if There is a Possible Association Between NAION and Phosphodiesterase Type 5 (PDE5) Inhibitors Completed NCT01131104 PDE5 Inhibitors
29 Epidemiology Study of Non-arteritic Anterior Ischemic Optic Neuropathy (NAION) Completed NCT01260324
30 Electric Stimulation of the Eye to Improve Vision After Trauma Completed NCT02019927 Not Applicable
31 Assessment of Visual Field-related Endpoints in Patients With Non-arteritic Ischemic Optic Neuropathy Completed NCT01614158
32 Safety and Efficacy of Using SightSaver Visual Evoked Potential (VEP) for VEP Monitoring in Prone Spine Surgery Completed NCT02643615 Not Applicable Propofol;Desflurane
33 Intraocular Pressure During Abdominal Aortic Aneurysm (AAA) Repair Completed NCT00450294
34 Determine the Effect of Intraocular Pressure (IOP), Optic Nerve Imaging, Venous Congestion in Volunteers Prone Position 5 Hours Completed NCT00875043
35 Effects of Sevoflurane and Propofol on Light Flashed Evoked Pupillometry Completed NCT01219569 propofol;Sevoflurane
36 Transcorneal Electrical Stimulation Therapy for Retinal Disease Completed NCT00804102 Not Applicable
37 Continuous Intraocular Pressure Patterns in Spine Surgery Completed NCT03299400 Not Applicable
38 Validation of the GATE Software Completed NCT01265628
39 Retinal Neuro-vascular Coupling in Patients With Non-arteritic Anterior Ischemic Optic Neuropathy Recruiting NCT03401892 Not Applicable
40 Effect of EECP on Anterior Ischemic Optic Neuropathy Recruiting NCT01768260 Not Applicable Aspirin
41 Biomechanics of Optic Neuropathy Recruiting NCT02982499
42 New Non-invasive Modalities for Assessing Retinal Structure and Function Recruiting NCT03475173 Not Applicable
43 Stem Cell Ophthalmology Treatment Study II Recruiting NCT03011541 Not Applicable
44 Influence of Oral Treatment With Citicoline for the Prevention of Radiation Optic Neuropathy in Patients Treated for Uveal Melanomas With Proton Beam Therapy Active, not recruiting NCT01338389 Not Applicable
45 Stem Cell Ophthalmology Treatment Study Enrolling by invitation NCT01920867 Not Applicable
46 Swept Source Enhanced Depth Imaging Optical Coherence Tomography Not yet recruiting NCT02443129 Not Applicable
47 Intraocular Pressure During Prone Spinal Surgery Terminated NCT00176722

Search NIH Clinical Center for Nonarteritic Anterior Ischemic Optic Neuropathy

Cochrane evidence based reviews: optic neuropathy, ischemic

Genetic Tests for Nonarteritic Anterior Ischemic Optic Neuropathy

Genetic tests related to Nonarteritic Anterior Ischemic Optic Neuropathy:

# Genetic test Affiliating Genes
1 Nonarteritic Anterior Ischemic Optic Neuropathy, Susceptibility to 29 GP1BA
2 Nonarteritic Anterior Ischemic Optic Neuropathy 29

Anatomical Context for Nonarteritic Anterior Ischemic Optic Neuropathy

MalaCards organs/tissues related to Nonarteritic Anterior Ischemic Optic Neuropathy:

41
Eye, Endothelial, Neutrophil, B Cells, Kidney, Retina, Heart

Publications for Nonarteritic Anterior Ischemic Optic Neuropathy

Articles related to Nonarteritic Anterior Ischemic Optic Neuropathy:

(show top 50) (show all 490)
# Title Authors Year
1
Hyperhomocysteinemia in bilateral anterior ischemic optic neuropathy after conventional coronary artery bypass graft: a case report. ( 29338755 )
2018
2
Pseudohemangioma in Nonarteritic Anterior Ischemic Optic Neuropathy. ( 29784095 )
2018
3
Quantitative analysis of optical coherence tomographic angiography (OCT-A) in patients with non-arteritic anterior ischemic optic neuropathy (NAION) corresponds to visual function. ( 29953490 )
2018
4
Could Buerger's disease cause nonarteritic anterior ischemic optic neuropathy?: a rare case report. ( 29623524 )
2018
5
Retinal and Choroidal Microvasculature in Nonarteritic Anterior Ischemic Optic Neuropathy: An Optical Coherence Tomography Angiography Study. ( 29490340 )
2018
6
Intravitreal Triamcinolone Acetonide Injection in a Rodent Model of Anterior Ischemic Optic Neuropathy. ( 29521709 )
2018
7
Acute Effect of Hypervolemic Hemodilution on Retrobulbar Hemodynamics in Anterior Ischemic Optic Neuropathy. ( 29546060 )
2018
8
The polymorphisms of ATOH 7, ET-1 and ACE in non-arteritic anterior ischemic optic neuropathy. ( 29792847 )
2018
9
Anomalous coagulation factors in non-arteritic anterior ischemic optic neuropathy with central retinal vein occlusion: A case report. ( 29642215 )
2018
10
The Association Between Phosphodiesterase Type 5 Inhibitor Use and Risk of Non-Arteritic Anterior Ischemic Optic Neuropathy: A Systematic Review and Meta-Analysis. ( 29884471 )
2018
11
Risk of Ischemic Kidney Injury in Patients With Nonarteritic Anterior Ischemic Optic Neuropathy: A Nationwide Population-based Study. ( 29330063 )
2018
12
Steroids versus No Steroids in Nonarteritic Anterior Ischemic Optic Neuropathy: A Randomized Controlled Trial. ( 29705054 )
2018
13
Optical Coherence Tomography Angiography of the Peripapillary Retina in Normal-Tension Glaucoma and Chronic Nonarteritic Anterior Ischemic Optic Neuropathy. ( 29451992 )
2018
14
Structural changes of macula and optic disk of the fellow eye in patients with nonarteritic anterior ischemic optic neuropathy. ( 29749568 )
2018
15
Anterior Ischemic Optic Neuropathy Due to Calciphylaxis. ( 29016409 )
2018
16
Lamina cribrosa position and Bruch's membrane opening differences between anterior ischemic optic neuropathy and open-angle glaucoma. ( 29911429 )
2018
17
The Effect of Combined Systemic Erythropoietin and Steroid on Non-arteritic Anterior Ischemic Optic Neuropathy: A Prospective Study. ( 28632028 )
2017
18
Increased Risk of Stroke in Patients With Nonarteritic Anterior Ischemic Optic Neuropathy: A Nationwide Retrospective CohortA Study. ( 28063480 )
2017
19
High-dose intravenous pulse steroid therapy for optic disc swelling and subretinal fluid in non-arteritic anterior ischemic optic neuropathy. ( 28303068 )
2017
20
New Treatments for Nonarteritic Anterior Ischemic Optic Neuropathy. ( 27886887 )
2017
21
Structure-Function Analysis of Nonarteritic Anterior Ischemic Optic Neuropathy and Age-Related Differences in Outcome. ( 28538035 )
2017
22
Retinal Vessel Density in Optical Coherence Tomography Angiography in Optic Atrophy after Nonarteritic Anterior Ischemic Optic Neuropathy. ( 28316838 )
2017
23
Optical coherence tomography angiography in acute arteritic and non-arteritic anterior ischemic optic neuropathy. ( 28861697 )
2017
24
Takayasu arteritis presenting as isolated anterior ischemic optic neuropathy. ( 28389774 )
2017
25
Corticosteroid Therapy in Nonarteritic Anterior Ischemic Optic Neuropathy. ( 28759499 )
2017
26
Comparison of the Retinal Microvascular Density Between Open Angle Glaucoma and Nonarteritic Anterior Ischemic Optic Neuropathy. ( 28687846 )
2017
27
Atrial fibrillation in retinal vascular occlusion disease and non-arteritic anterior ischemic optic neuropathy. ( 28771491 )
2017
28
Assessment of nonarteritic anterior ischemic optic neuropathy with intravoxel incoherent motion diffusion-weighted imaging using readout-segmented echo-planar imaging, parallel imaging, and 2D navigator-based reacquisition. ( 28513892 )
2017
29
Microvasculature dropout detected by the optical coherence tomography angiography in nonarteritic anterior ischemic optic neuropathy. ( 28986994 )
2017
30
Bilateral Arteritic Anterior Ischemic Optic Neuropathy Associated with Giant Cell Arteritis in Korea. ( 28994270 )
2017
31
Comparison of Optic Nerve Head Morphology in Patients with Primary Open Angle Glaucoma and Non-Arteritic Anterior Ischemic Optic Neuropathy. ( 29485789 )
2017
32
Corticosteroid Therapy in Nonarteritic Anterior Ischemic Optic Neuropathy: Response. ( 28759500 )
2017
33
Visual outcome following bilateral non-arteritic anterior ischemic optic neuropathy: a systematic review and meta-analysis. ( 28836961 )
2017
34
Automated Evaluation of Choroidal Thickness and Minimum Rim Width Thickness in Nonarteritic Anterior Ischemic Optic Neuropathy. ( 28885450 )
2017
35
Role of Nocturnal Arterial Hypotension in Nonarteritic Anterior Ischemic Optic Neuropathy. ( 28742640 )
2017
36
Dalfampridine Treatment in Nonarteritic Anterior Ischemic Optic Neuropathy. ( 28538037 )
2017
37
Postural effects on intraocular pressure and ocular perfusion pressure in patients with non-arteritic anterior ischemic optic neuropathy. ( 28427356 )
2017
38
Optical Coherence Tomography Angiography in Nonarteritic Anterior Ischemic Optic Neuropathy. ( 28301863 )
2017
39
Aqueous Humor Cytokines in Patients With Acute Nonarteritic Anterior Ischemic Optic Neuropathy. ( 28302535 )
2017
40
Giant cell arteritis with arteritic anterior ischemic optic neuropathy. ( 28523333 )
2017
41
Prospective Case-crossover Study Investigating the Possible Association Between Nonarteritic Anterior Ischemic Optic Neuropathy and Phosphodiesterase Type 5 Inhibitor Exposure. ( 28336289 )
2017
42
Erectile Dysfunction Agents and Nonarteritic Anterior Ischemic Optic Neuropathy. ( 27886893 )
2017
43
Nonarteritic anterior ischemic optic neuropathy: cause, effect, and management. ( 29033621 )
2017
44
A case of non-arteritic anterior ischemic optic neuropathy after completion of Harvoni therapy. ( 29260058 )
2017
45
Does Nocturnal Hypotension Play a Causal Role in Nonarteritic Anterior Ischemic Optic Neuropathy?: Response. ( 28742641 )
2017
46
Sequential development of non-arteritic anterior ischemic optic neuropathy in a patient on hemodialysis. ( 28944153 )
2017
47
OCT angiography of acute non-arteritic anterior ischemic optic neuropathy. ( 28117076 )
2017
48
Increased Risk of Stroke in Patients With Nonarteritic Anterior Ischemic Optic Neuropathy: A Nationwide Retrospective Cohort Study. ( 28093100 )
2017
49
Aqueous Humor Cytokines in Patients With Acute Nonarteritic Anterior Ischemic Optic Neuropathy. ( 28438311 )
2017
50
Nonarteritic Anterior Ischemic Optic Neuropathy Induced Retinal Folds and Deformations. ( 28846776 )
2017

Variations for Nonarteritic Anterior Ischemic Optic Neuropathy

ClinVar genetic disease variations for Nonarteritic Anterior Ischemic Optic Neuropathy:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 GP1BA GP1BA, 92-BP DUP, SER399-THR411 DUP, VARIABLE REPEATS duplication risk factor
2 GP1BA NM_000173.6(GP1BA): c.256C> T (p.Leu86Phe) single nucleotide variant Likely benign rs13306411 GRCh38 Chromosome 17, 4932860: 4932860
3 GP1BA NM_000173.6(GP1BA): c.256C> T (p.Leu86Phe) single nucleotide variant Likely benign rs13306411 GRCh37 Chromosome 17, 4836155: 4836155

Expression for Nonarteritic Anterior Ischemic Optic Neuropathy

Search GEO for disease gene expression data for Nonarteritic Anterior Ischemic Optic Neuropathy.

Pathways for Nonarteritic Anterior Ischemic Optic Neuropathy

GO Terms for Nonarteritic Anterior Ischemic Optic Neuropathy

Biological processes related to Nonarteritic Anterior Ischemic Optic Neuropathy according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.73 F2 F5 SERPINC1
2 blood circulation GO:0008015 9.58 F5 MTHFR
3 response to amino acid GO:0043200 9.58 EDN1 MTHFR
4 regulation of blood pressure GO:0008217 9.58 ACE EDN1 NOS3
5 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway GO:0051482 9.57 AGTR1 EDN1
6 blood coagulation GO:0007596 9.56 F2 F5 GP1BA SERPINC1
7 blood vessel remodeling GO:0001974 9.55 ACE NOS3
8 positive regulation of reactive oxygen species metabolic process GO:2000379 9.54 AGTR1 F2
9 positive regulation of cardiac muscle hypertrophy GO:0010613 9.52 EDN1 PDE5A
10 fibrinolysis GO:0042730 9.51 F2 GP1BA
11 regulation of blood vessel size GO:0050880 9.49 EDN1 NOS3
12 blood coagulation, intrinsic pathway GO:0007597 9.48 F2 GP1BA
13 regulation of blood vessel diameter GO:0097746 9.46 ACE AGTR1
14 negative regulation of platelet activation GO:0010544 9.43 F2 NOS3
15 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 9.37 ACE AGTR1
16 regulation of vasoconstriction GO:0019229 9.33 ACE AGTR1 EDN1
17 regulation of systemic arterial blood pressure by endothelin GO:0003100 9.32 EDN1 NOS3
18 regulation of blood coagulation GO:0030193 9.13 F2 GP1BA SERPINC1
19 hemostasis GO:0007599 8.92 F2 F5 GP1BA SERPINC1

Molecular functions related to Nonarteritic Anterior Ischemic Optic Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 NADP binding GO:0050661 8.96 MTHFR NOS3
2 bradykinin receptor binding GO:0031711 8.62 ACE AGTR1

Sources for Nonarteritic Anterior Ischemic Optic Neuropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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