NAION
MCID: NNR004
MIFTS: 56

Nonarteritic Anterior Ischemic Optic Neuropathy (NAION)

Categories: Eye diseases, Genetic diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Nonarteritic Anterior Ischemic Optic Neuropathy

MalaCards integrated aliases for Nonarteritic Anterior Ischemic Optic Neuropathy:

Name: Nonarteritic Anterior Ischemic Optic Neuropathy 58 12 74
Anterior Ischemic Optic Neuropathy 12 54 76 15 17 74
Nonarteritic Anterior Ischemic Optic Neuropathy, Susceptibility to 58 30 13 6
Non-Arteritic Anterior Ischemic Optic Neuropathy 12 76 15
Naion 58 76 56
Optic Neuropathy, Ischemic 45 74
Ischemic Optic Neuropathy 12 54
Aion 54 76
Neuropathy, Optic, Ischemic, Nonarteritic Anterior, Susceptibility to 41
Optic Neuropathy, Anterior Ischemic, Susceptibility to 58
Optic Neuropathy, Anterior Ischemic 58
Naion, Susceptibility to 58

Characteristics:

OMIM:

58
Inheritance:
autosomal recessive


HPO:

33
nonarteritic anterior ischemic optic neuropathy:
Inheritance autosomal recessive inheritance


Classifications:



External Ids:

Disease Ontology 12 DOID:0050864 DOID:12010
OMIM 58 258660
ICD9CM 36 377.41
MeSH 45 D018917
SNOMED-CT 69 14357004
ICD10 34 H47.01
MedGen 43 C1847711
SNOMED-CT via HPO 70 258211005

Summaries for Nonarteritic Anterior Ischemic Optic Neuropathy

NIH Rare Diseases : 54 Anterior ischemic optic neuropathy (AION) is an eye disease characterized by infarction of the optic disk leading to vision loss. It can be nonarteritic (nonarteritic anterior ischemic optic neuropathy or NAION) or arteritic, the latter being associated with giant cell arteritis (GCA; often termed temporal arteritis).Vision loss with both varieties is typically rapid (over minutes, hours, or days) and painless. Symptoms such as a general feeling of being unwell (malaise), muscle aches and pains, headaches over the temple, pain when combing hair, pain in the jaw after chewing, and tenderness over the temporal artery (one of the major arteries of the head) may be present with giant cell arteritis. At exam, visual acuity is reduced and the optic disc is swollen. In both subtypes, visual field examination is often reduced in the inferior and central visual fields.The visual loss is usually permanent, with some recovery possibly occurring within the first weeks or months. The arteritic variety is treated with corticosteroids. Treatment of the nonarteritic variety with aspirin or corticosteroids has not been helpful. 

MalaCards based summary : Nonarteritic Anterior Ischemic Optic Neuropathy, also known as anterior ischemic optic neuropathy, is related to impotence and sleep apnea. An important gene associated with Nonarteritic Anterior Ischemic Optic Neuropathy is GP1BA (Glycoprotein Ib Platelet Subunit Alpha), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Development Angiotensin activation of ERK. The drugs Carbidopa and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include eye, kidney and endothelial, and related phenotypes are nonarteritic anterior ischemic optic neuropathy and cardiovascular system

Disease Ontology : 12 An anterior ischemic optic neuropathy that is characterized by near-complete vision loss caused by acute ischemic damage to the optic nerve due to non-inflammatory small vessel disease.

UniProtKB/Swiss-Prot : 76 Non-arteritic anterior ischemic optic neuropathy: An ocular disease due to ischemic injury to the optic nerve. It usually affects the optic disk and leads to visual loss and optic disk swelling of a pallid nature. Visual loss is usually sudden, or over a few days at most and is usually permanent, with some recovery possibly occurring within the first weeks or months. Patients with small disks having smaller or non-existent cups have an anatomical predisposition for non-arteritic anterior ischemic optic neuropathy. As an ischemic episode evolves, the swelling compromises circulation, with a spiral of ischemia resulting in further neuronal damage.

Wikipedia : 77 Anterior ischemic optic neuropathy (AION) is a medical condition involving loss of vision caused by... more...

Description from OMIM: 258660

Related Diseases for Nonarteritic Anterior Ischemic Optic Neuropathy

Diseases related to Nonarteritic Anterior Ischemic Optic Neuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 263)
# Related Disease Score Top Affiliating Genes
1 impotence 30.9 EDN1 NOS3 PDE5A
2 sleep apnea 30.8 ACE EDN1 NOS3
3 branch retinal artery occlusion 30.4 F2 MTHFR SERPINC1
4 thrombophilia 30.4 F2 MTHFR SERPINC1
5 antiphospholipid syndrome 30.3 F2 MTHFR SERPINC1
6 central retinal vein occlusion 30.1 F2 MTHFR SERPINC1
7 retinal vein occlusion 30.1 F2 MTHFR SERPINC1
8 retinal vascular disease 30.1 ACE MTHFR
9 ischemia 30.1 ACE EDN1 NOS3
10 retinal artery occlusion 30.1 ACE F2 MTHFR SERPINC1
11 migraine with aura 30.1 ACE MTHFR
12 pulmonary hypertension 29.9 ACE EDN1 NOS3 PDE5A
13 retinal vascular occlusion 29.9 F2 MTHFR SERPINC1
14 diabetes mellitus 29.8 ACE AGTR1 EDN1 NOS3
15 thrombosis 29.7 F2 GP1BA MTHFR SERPINC1
16 spinal cord infarction 29.7 F2 MTHFR SERPINC1
17 thrombophilia due to activated protein c resistance 29.6 F2 MTHFR SERPINC1
18 arteritic anterior ischemic optic neuropathy 29.6 ACE F2 GP1BA MTHFR NOS3 PDE5A
19 malignant hypertension 29.5 ACE AGTR1 EDN1
20 ischemic optic neuropathy 29.4 ACE AGTR1 EDN1 F2 GP1BA MTHFR
21 microvascular complications of diabetes 5 29.4 ACE AGTR1 NOS3
22 atrial fibrillation 29.3 ACE AGTR1 F2
23 hellp syndrome 29.3 EDN1 F2 MTHFR SERPINC1
24 homocysteinemia 29.2 F2 MTHFR NOS3 SERPINC1
25 stroke, ischemic 28.9 ACE AGTR1 F2 MTHFR NOS3 SERPINC1
26 vascular disease 28.2 ACE EDN1 F2 GP1BA MTHFR NOS3
27 optic nerve disease 11.4
28 neuropathy 11.4
29 optic neuritis 10.5
30 neuritis 10.5
31 low tension glaucoma 10.4
32 papilledema 10.4
33 cataract 10.3
34 open-angle glaucoma 10.3
35 central retinal artery occlusion 10.3
36 glaucomatocyclitic crisis 10.3
37 refractive error 10.3
38 cerebral atherosclerosis 10.3 ACE MTHFR
39 hemifacial spasm 10.2 MTHFR NOS3
40 renal artery obstruction 10.2 ACE SERPINC1
41 coronary restenosis 10.2 ACE SERPINC1
42 temporal arteritis 10.2
43 3-methylglutaconic aciduria, type iii 10.2
44 myelodysplastic syndrome 10.2
45 diffuse large b-cell lymphoma 10.2
46 end stage renal failure 10.2
47 hepatitis 10.2
48 liver disease 10.2
49 lymphoma 10.2
50 optic disk drusen 10.2

Comorbidity relations with Nonarteritic Anterior Ischemic Optic Neuropathy via Phenotypic Disease Network (PDN):


Hypertension, Essential Temporal Arteritis

Graphical network of the top 20 diseases related to Nonarteritic Anterior Ischemic Optic Neuropathy:



Diseases related to Nonarteritic Anterior Ischemic Optic Neuropathy

Symptoms & Phenotypes for Nonarteritic Anterior Ischemic Optic Neuropathy

Human phenotypes related to Nonarteritic Anterior Ischemic Optic Neuropathy:

33
# Description HPO Frequency HPO Source Accession
1 nonarteritic anterior ischemic optic neuropathy 33 HP:0007634

Symptoms via clinical synopsis from OMIM:

58
Eyes:
nonarteritic anterior ischemic optic neuropathy
papillophlebitis

Clinical features from OMIM:

258660

MGI Mouse Phenotypes related to Nonarteritic Anterior Ischemic Optic Neuropathy:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.63 ACE AGTR1 EDN1 F2 NOS3 SERPINC1
2 homeostasis/metabolism MP:0005376 9.56 ACE AGTR1 EDN1 F2 GP1BA MTHFR
3 renal/urinary system MP:0005367 9.02 ACE AGTR1 EDN1 NOS3 SERPINC1

Drugs & Therapeutics for Nonarteritic Anterior Ischemic Optic Neuropathy

Drugs for Nonarteritic Anterior Ischemic Optic Neuropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 91)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Carbidopa Approved Phase 4 28860-95-9 34359
2
Dopamine Approved Phase 4 62-31-7, 51-61-6 681
3
Levodopa Approved Phase 4 59-92-7 6047
4
4-Aminopyridine Approved Phase 4 504-24-5 1727
5
Tadalafil Approved, Investigational Phase 4 171596-29-5 110635
6
Choline Approved, Nutraceutical Phase 4,Not Applicable 62-49-7 305
7 Immunologic Factors Phase 4,Phase 3,Phase 1,Phase 2
8 Gastrointestinal Agents Phase 4,Phase 3,Phase 2
9 Nootropic Agents Phase 4,Not Applicable
10 Cytidine Diphosphate Choline Phase 4,Not Applicable
11 Antiparkinson Agents Phase 4
12 Adjuvants, Immunologic Phase 4
13 Aromatic Amino Acid Decarboxylase Inhibitors Phase 4
14 Dopamine Agents Phase 4
15 Carbidopa, levodopa drug combination Phase 4
16 Neurotransmitter Agents Phase 4,Phase 1
17 Dopamine agonists Phase 4
18 Potassium Channel Blockers Phase 4
19 Adrenergic alpha-Agonists Phase 4
20 Adrenergic Agonists Phase 4
21 Laxatives Phase 4
22 Adrenergic Agents Phase 4,Phase 1
23 Ophthalmic Solutions Phase 4
24 Cathartics Phase 4
25 Adrenergic alpha-2 Receptor Agonists Phase 4
26 Antihypertensive Agents Phase 4,Phase 3,Phase 1
27 Carboxymethylcellulose Sodium Phase 4
28 Brimonidine Tartrate Phase 4 70359-46-5
29 Pharmaceutical Solutions Phase 4,Phase 2,Not Applicable
30 Phosphodiesterase Inhibitors Phase 4,Phase 2
31 Sildenafil Citrate Phase 4 171599-83-0
32 Phosphodiesterase 5 Inhibitors Phase 4
33 Vardenafil Dihydrochloride Phase 4
34
Prednisolone phosphate Approved, Vet_approved Phase 3,Phase 2 302-25-0
35
Methylprednisolone hemisuccinate Approved Phase 3,Phase 2 2921-57-5
36
Prednisolone Approved, Vet_approved Phase 3,Phase 2 50-24-8 5755
37
Methylprednisolone Approved, Vet_approved Phase 3,Phase 2 83-43-2 6741
38
Triamcinolone Approved, Vet_approved Phase 3,Phase 1,Phase 2 124-94-7 31307
39
Bosentan Approved, Investigational Phase 3 147536-97-8 104865
40
Prednisolone hemisuccinate Experimental Phase 3,Phase 2 2920-86-7
41 Prednisolone acetate Phase 3,Phase 2
42 Antineoplastic Agents, Hormonal Phase 3,Phase 2
43 Hormones Phase 3,Phase 1,Phase 2
44 Neuroprotective Agents Phase 3,Phase 2,Phase 1
45 Anti-Inflammatory Agents Phase 3,Phase 1,Phase 2,Not Applicable
46 Protective Agents Phase 3,Phase 2
47 Antiemetics Phase 3,Phase 2
48 glucocorticoids Phase 3,Phase 1,Phase 2
49 Autonomic Agents Phase 3,Phase 2
50 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 1,Phase 2

Interventional clinical trials:

(show top 50) (show all 52)
# Name Status NCT ID Phase Drugs
1 Citicoline Effect on Non-arteritic Anterior Ischemic Optic Neuropathy (NAION) Completed NCT03046693 Phase 4 Group A Citicoline 1000 mg oral tablet;Group B placebo oral tablet
2 Effect of Levodopa-Carbidopa on Visual Function in Patients With Recent-Onset Nonarteritic Anterior Ischemic Optic Neuropathy Completed NCT00432393 Phase 4 levodopa-carbidopa
3 A New Medicine to Treat Nonarteritic Anterior Ischemic Optic Neuropathy (NAION) Completed NCT01975324 Phase 4 dalfampridine;Placebo
4 Preoperative Brimonidine on IOP of Patients Undergoing RALP Completed NCT02818816 Phase 4 brimonidine tartrate 0.2%
5 Neural Conduction Along the Visual Pathways After Oral Treatment With Citicoline in Patients With Optic Nerve Diseases Completed NCT00404729 Phase 4 Cytidine-5’-diphosphocholine (Citicoline)
6 PDE5 Inhibitor Use and Non-arteritic Anterior Ischemic Optic Neuropathy (NAION) Terminated NCT00867815 Phase 4 Diagnostic procedures
7 Outcomes of Steroid and Oxygen Therapy Versus Placebo Therapy in Non-arteritic Anterior Ischemic Optic Neuropathy Unknown status NCT02439866 Phase 3 placebo;Intravenous methylprednisolone;normobaric oxygen with face mask
8 Retrobulbar Triamcinolone Acetonide Injection in the Treatment of NA-AION Unknown status NCT02329288 Phase 3 Triamcinolone Acetonide;placebo
9 Ischemic Optic Neuropathy Decompression Trial (IONDT) Completed NCT00000127 Phase 3
10 Phase 2/3, Randomized, Double-Masked, Sham-Controlled Trial of QPI-1007 in Subjects With Acute Nonarteritic Anterior Ischemic Optic Neuropathy (NAION) Recruiting NCT02341560 Phase 2, Phase 3 QPI-1007 Injection - 1.5 mg;QPI-1007 Injection - 3.0 mg
11 Efficacy & Safety of RPh201 Treatment in Patients With Previous Nonarteritic Anterior Ischemic Optic Neuropathy (NAION) Recruiting NCT03547206 Phase 3 RPh201
12 ENDOTHELION Study Group: Effect of Bosentan in NAION Patients Recruiting NCT02377271 Phase 3 bosentan;placebo
13 Erythropoietin in Methanol Associated Optic Neuropathy: A Phase-2 Clinical Trial (EPO-MAON Study) Active, not recruiting NCT02376881 Phase 3 Erythropoietin
14 Study of the Benefit of Early Treatment With an Endothelin Inhibitor (Bosentan) in Patients With Sudden Blindness Due to Giant Cell Arteritis: CECIBO Not yet recruiting NCT03841734 Phase 3 treatment
15 Comparison of Intravitreal Bevacizumab and Triamcinolone With Placebo Unknown status NCT01330524 Phase 1, Phase 2 Avastin and Triamcinolone
16 Intravitreal Bevacizumab for Non-Arteritic Anterior Ischemic Optic Neuropathy Unknown status NCT00813059 Phase 2 Intra-vitreal injection of bevacizumab (1.25mg/0.05ml)
17 Neurotomy of Optic Nerve in Non-Arthritic Anterior Ischemic Optic Neuropathy Completed NCT00372021 Phase 1, Phase 2
18 Safety and Efficacy Study of RPh201 Treatment of Ischemic Optic Neuropathy (ION). Completed NCT02045212 Phase 2 RPh201;Placebo
19 Effects of Moxaverine and Placebo on Ocular Blood Flow Completed NCT00709423 Phase 2 Moxaverine;Moxaverin 150mg;NaCl
20 Safety Assessment of Intravitreal Mesenchymal Stem Cells for Acute Non Arteritic Anterior Ischemic Optic Neuropathy Recruiting NCT03173638 Phase 2
21 NAION Treatment With Oral Prednisolone and Erythropoietin Injection Recruiting NCT03715881 Phase 2 Oral prednisolone administration 50 mg;Intravenous Erythropoietin injection
22 Intravenous Infusion of Prostaglandins as Therapy in Patients With Anterior Non-arteritic Ischemic Optic Neuropathy Recruiting NCT03851562 Phase 2 Alprostadil 20 micrograms;Placebo
23 A Phase I Clinical Trial of DARC Unknown status NCT02394613 Phase 1 ANX776
24 Safety Study of a Single IVT Injection of QPI-1007 in Chronic Optic Nerve Atrophy and Recent Onset NAION Patients Completed NCT01064505 Phase 1 QPI-1007 at various doses
25 Ranibizumab Therapy for Non-arteritic Ischemic Optic Neuropathy Completed NCT00561834 Phase 1 ranibizumab
26 NT-501 CNTF Implant for Ischemic Optic Neuropathy: Safety, Neuroprotection and Neuroenhancement Completed NCT01411657 Phase 1 NT-501 CNTF Implant
27 Treatment Study for Ischemic Optic Neuropathy With Opthalmic Timolol Maleate 0.5% Withdrawn NCT01607671 Phase 1 Timolol maleate
28 Effect of EECP on Anterior Ischemic Optic Neuropathy Unknown status NCT01768260 Not Applicable Aspirin
29 Ischemic Optic Neuropathy Decompression Trial Followup (IONDT Followup) Unknown status NCT00000126
30 Study of Ocular Blood Flow in Patients With Glaucoma and/or Obstructive Sleep Apnea Syndrome (OSAS) Unknown status NCT00874913 Not Applicable
31 Vision Restoration Therapy (VRT) to Treat Non-Arteritic Anterior Ischemic Optic Neuropathy Completed NCT00140491 Not Applicable
32 A Study to Determine if There is a Possible Association Between NAION and Phosphodiesterase Type 5 (PDE5) Inhibitors Completed NCT01131104 PDE5 Inhibitors
33 Epidemiology Study of Non-arteritic Anterior Ischemic Optic Neuropathy (NAION) Completed NCT01260324
34 Electric Stimulation of the Eye to Improve Vision After Trauma Completed NCT02019927 Not Applicable
35 Citicoline in Non-Arteritic Ischemic Optic Neuropathy Completed NCT03758118 Not Applicable
36 Assessment of Visual Field-related Endpoints in Patients With Non-arteritic Ischemic Optic Neuropathy Completed NCT01614158
37 Safety and Efficacy of Using SightSaver Visual Evoked Potential (VEP) for VEP Monitoring in Prone Spine Surgery Completed NCT02643615 Not Applicable Propofol;Desflurane
38 Intraocular Pressure During Abdominal Aortic Aneurysm (AAA) Repair Completed NCT00450294
39 Determine the Effect of Intraocular Pressure (IOP), Optic Nerve Imaging, Venous Congestion in Volunteers Prone Position 5 Hours Completed NCT00875043
40 Effects of Sevoflurane and Propofol on Light Flashed Evoked Pupillometry Completed NCT01219569 propofol;Sevoflurane
41 Transcorneal Electrical Stimulation Therapy for Retinal Disease Completed NCT00804102 Not Applicable
42 Continuous Intraocular Pressure Patterns in Spine Surgery Completed NCT03299400 Not Applicable
43 Validation of the GATE Software Completed NCT01265628
44 Retinal Neuro-vascular Coupling in Patients With Non-arteritic Anterior Ischemic Optic Neuropathy Recruiting NCT03401892 Not Applicable
45 OCT Angiography in Arteritic and Non Arteritic Anterior Ischemic Neuropathy Recruiting NCT03642899
46 Biomechanics of Optic Neuropathy Recruiting NCT02982499
47 New Non-invasive Modalities for Assessing Retinal Structure and Function Recruiting NCT03475173 Not Applicable
48 Stem Cell Ophthalmology Treatment Study II Recruiting NCT03011541 Not Applicable
49 Influence of Oral Treatment With Citicoline for the Prevention of Radiation Optic Neuropathy in Patients Treated for Uveal Melanomas With Proton Beam Therapy Active, not recruiting NCT01338389 Not Applicable
50 Stem Cell Ophthalmology Treatment Study Enrolling by invitation NCT01920867 Not Applicable

Search NIH Clinical Center for Nonarteritic Anterior Ischemic Optic Neuropathy

Cochrane evidence based reviews: optic neuropathy, ischemic

Genetic Tests for Nonarteritic Anterior Ischemic Optic Neuropathy

Genetic tests related to Nonarteritic Anterior Ischemic Optic Neuropathy:

# Genetic test Affiliating Genes
1 Nonarteritic Anterior Ischemic Optic Neuropathy, Susceptibility to 30 GP1BA

Anatomical Context for Nonarteritic Anterior Ischemic Optic Neuropathy

MalaCards organs/tissues related to Nonarteritic Anterior Ischemic Optic Neuropathy:

42
Eye, Kidney, Endothelial, Neutrophil, Brain, B Cells, Retina

Publications for Nonarteritic Anterior Ischemic Optic Neuropathy

Articles related to Nonarteritic Anterior Ischemic Optic Neuropathy:

(show top 50) (show all 599)
# Title Authors Year
1
Giant cell arteritis related arteritic anterior ischemic optic neuropathy: Clinico-pathological correlation. ( 30574925 )
2019
2
Characterization of retinal microvasculature in acute non-arteritic anterior ischemic optic neuropathy using the retinal functional imager: a prospective case series. ( 30675495 )
2019
3
Systemic oxidative stress in non-arteritic anterior ischemic optic neuropathy. ( 30833666 )
2019
4
Abnormal spontaneous brain activity in patients with non-arteritic anterior ischemic optic neuropathy detected using functional magnetic resonance imaging. ( 30855358 )
2019
5
Choroidal Vascular Changes in Arteritic and Non-arteritic Anterior Ischemic Optic Neuropathy. ( 30954470 )
2019
6
Retinal Vessel Phenotype in Patients with Non-Arteritic Anterior Ischemic Optic Neuropathy. ( 31004591 )
2019
7
Comment on: Optical coherence tomography angiography in acute unilateral nonarteritic anterior ischemic optic neuropathy: A comparison with the fellow eye and with eyes with papilledema. ( 30574942 )
2019
8
Response to comment on: Optical coherence tomography angiography in acute unilateral nonarteritic anterior ischemic optic neuropathy: A comparison with the fellow eye and with eyes with papilledema. ( 30574943 )
2019
9
Risk of Stroke after Nonarteritic Anterior Ischemic Optic Neuropathy. ( 30633893 )
2019
10
A comparative study on clinical features of anterior ischemic optic neuropathy and idiopathic optic neuritis. ( 30784250 )
2019
11
Early Ganglion Cell or Macular Vessel Loss After Acute Nonarteritic Anterior Ischemic Optic Neuropathy? ( 30972233 )
2019
12
Anterior Ischemic Optic Neuropathy After Dental Extraction: Response. ( 31094998 )
2019
13
Anterior Ischemic Optic Neuropathy After Dental Extraction: Comment. ( 31094999 )
2019
14
Risk of Stroke After Nonarteritic Anterior Ischemic Optic Neuropathy. ( 31109627 )
2019
15
Lamina cribrosa position and Bruch's membrane opening differences between anterior ischemic optic neuropathy and open-angle glaucoma. ( 29911429 )
2019
16
Anterior Ischemic Optic Neuropathy After Dental Extraction. ( 30179990 )
2019
17
Risk Factors for Fellow Eye Involvement in Nonarteritic Anterior Ischemic Optic Neuropathy. ( 30300257 )
2019
18
Sequential nonarteritic anterior ischemic optic neuropathy in patient on chronic hemodialysis. ( 30460468 )
2019
19
Anomalous coagulation factors in non-arteritic anterior ischemic optic neuropathy with central retinal vein occlusion: A case report. ( 29642215 )
2018
20
The polymorphisms of ATOH 7, ET-1 and ACE in non-arteritic anterior ischemic optic neuropathy. ( 29792847 )
2018
21
The Association Between Phosphodiesterase Type 5 Inhibitor Use and Risk of Non-Arteritic Anterior Ischemic Optic Neuropathy: A Systematic Review and Meta-Analysis. ( 29884471 )
2018
22
Quantitative analysis of optical coherence tomographic angiography (OCT-A) in patients with non-arteritic anterior ischemic optic neuropathy (NAION) corresponds to visual function. ( 29953490 )
2018
23
Three-Dimensional High-Resolution Black-Blood Magnetic Resonance Imaging for Detection of Arteritic Anterior Ischemic Optic Neuropathy in Patients With Giant Cell Arteritis. ( 30095558 )
2018
24
Giant Cell Arteritis Associated Arteritic Anterior Ischemic Optic Neuropathy: Sudden Vision Loss on the Contralateral Side of Headache. ( 30198237 )
2018
25
Non-Arteritic Anterior Ischemic Optic Neuropathy in Pilots. ( 30352654 )
2018
26
Non-arteritic anterior ischemic optic neuropathy - Case report. ( 30505994 )
2018
27
Anterior Ischemic Optic Neuropathy Due to Calciphylaxis. ( 29016409 )
2018
28
Cilioretinal artery occlusion and anterior ischemic optic neuropathy as the initial presentation in a child female carrier of Fabry disease. ( 28281207 )
2018
29
A rodent model of anterior ischemic optic neuropathy (AION) based on laser photoactivation of verteporfin. ( 30466418 )
2018
30
Optic nerve head width and retinal nerve fiber layer changes are proper indexes for validating the successful induction of experimental anterior ischemic optic neuropathy. ( 30557569 )
2018
31
Macular evaluation of the retinal and choroidal vasculature changes in anterior ischemic optic neuropathy-a case control study. ( 30594154 )
2018
32
Ocular Hemodynamics in Acute Nonarteritic Anterior Ischemic Optic Neuropathy Compared to Normal Tension Glaucoma. ( 30601221 )
2018
33
Longitudinal Measurement of Hemodynamic Changes within the Posterior Optic Nerve Head in Rodent Nonarteritic Anterior Ischemic Optic Neuropathy. ( 30646989 )
2018
34
Takayasu arteritis presenting as isolated anterior ischemic optic neuropathy. ( 28389774 )
2018
35
Automated Evaluation of Choroidal Thickness and Minimum Rim Width Thickness in Nonarteritic Anterior Ischemic Optic Neuropathy. ( 28885450 )
2018
36
Microvasculature dropout detected by the optical coherence tomography angiography in nonarteritic anterior ischemic optic neuropathy. ( 28986994 )
2018
37
Risk of Ischemic Kidney Injury in Patients With Nonarteritic Anterior Ischemic Optic Neuropathy: A Nationwide Population-based Study. ( 29330063 )
2018
38
Hyperhomocysteinemia in bilateral anterior ischemic optic neuropathy after conventional coronary artery bypass graft: a case report. ( 29338755 )
2018
39
Optical Coherence Tomography Angiography of the Peripapillary Retina in Normal-Tension Glaucoma and Chronic Nonarteritic Anterior Ischemic Optic Neuropathy. ( 29451992 )
2018
40
Retinal and Choroidal Microvasculature in Nonarteritic Anterior Ischemic Optic Neuropathy: An Optical Coherence Tomography Angiography Study. ( 29490340 )
2018
41
Intravitreal Triamcinolone Acetonide Injection in a Rodent Model of Anterior Ischemic Optic Neuropathy. ( 29521709 )
2018
42
Acute Effect of Hypervolemic Hemodilution on Retrobulbar Hemodynamics in Anterior Ischemic Optic Neuropathy. ( 29546060 )
2018
43
Could Buerger's disease cause nonarteritic anterior ischemic optic neuropathy?: a rare case report. ( 29623524 )
2018
44
Steroids versus No Steroids in Nonarteritic Anterior Ischemic Optic Neuropathy: A Randomized Controlled Trial. ( 29705054 )
2018
45
Structural changes of macula and optic disk of the fellow eye in patients with nonarteritic anterior ischemic optic neuropathy. ( 29749568 )
2018
46
Pseudohemangioma in Nonarteritic Anterior Ischemic Optic Neuropathy. ( 29784095 )
2018
47
Optical coherence tomography angiography in acute unilateral nonarteritic anterior ischemic optic neuropathy: A comparison with the fellow eye and with eyes with papilledema. ( 30038161 )
2018
48
Spectral-Domain Optical Coherence Tomography of the Vitreopapillary Interface in Acute Nonarteritic Anterior Ischemic Optic Neuropathy. ( 30098345 )
2018
49
Peripapillary retinal nerve fiber layer and macular ganglion cell complex thickness in patients with chronic phase of nonarteritic anterior ischemic optic neuropathy. ( 30206557 )
2018
50
Anterior Ischemic Optic Neuropathy in a Patient with Erectile Dysfunction: Tadalafil as an Offending Medication. ( 30211242 )
2018

Variations for Nonarteritic Anterior Ischemic Optic Neuropathy

ClinVar genetic disease variations for Nonarteritic Anterior Ischemic Optic Neuropathy:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 GP1BA GP1BA, 92-BP DUP, SER399-THR411 DUP, VARIABLE REPEATS duplication risk factor
2 GP1BA NM_000173.6(GP1BA): c.256C> T (p.Leu86Phe) single nucleotide variant Likely benign rs13306411 GRCh38 Chromosome 17, 4932860: 4932860
3 GP1BA NM_000173.6(GP1BA): c.256C> T (p.Leu86Phe) single nucleotide variant Likely benign rs13306411 GRCh37 Chromosome 17, 4836155: 4836155

Expression for Nonarteritic Anterior Ischemic Optic Neuropathy

Search GEO for disease gene expression data for Nonarteritic Anterior Ischemic Optic Neuropathy.

Pathways for Nonarteritic Anterior Ischemic Optic Neuropathy

GO Terms for Nonarteritic Anterior Ischemic Optic Neuropathy

Biological processes related to Nonarteritic Anterior Ischemic Optic Neuropathy according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 cell surface receptor signaling pathway GO:0007166 9.75 EDN1 F2 GP1BA
2 blood coagulation GO:0007596 9.7 F2 GP1BA SERPINC1
3 response to amino acid GO:0043200 9.57 EDN1 MTHFR
4 blood vessel remodeling GO:0001974 9.56 ACE NOS3
5 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway GO:0051482 9.55 AGTR1 EDN1
6 positive regulation of reactive oxygen species metabolic process GO:2000379 9.54 AGTR1 F2
7 positive regulation of cardiac muscle hypertrophy GO:0010613 9.51 EDN1 PDE5A
8 fibrinolysis GO:0042730 9.49 F2 GP1BA
9 regulation of blood vessel size GO:0050880 9.48 EDN1 NOS3
10 blood coagulation, intrinsic pathway GO:0007597 9.46 F2 GP1BA
11 regulation of blood vessel diameter GO:0097746 9.43 ACE AGTR1
12 regulation of blood pressure GO:0008217 9.43 ACE EDN1 NOS3
13 negative regulation of platelet activation GO:0010544 9.4 F2 NOS3
14 regulation of systemic arterial blood pressure by endothelin GO:0003100 9.37 EDN1 NOS3
15 hemostasis GO:0007599 9.33 F2 GP1BA SERPINC1
16 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 9.32 ACE AGTR1
17 regulation of vasoconstriction GO:0019229 9.13 ACE AGTR1 EDN1
18 regulation of blood coagulation GO:0030193 8.8 F2 GP1BA SERPINC1

Molecular functions related to Nonarteritic Anterior Ischemic Optic Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 NADP binding GO:0050661 8.96 MTHFR NOS3
2 bradykinin receptor binding GO:0031711 8.62 ACE AGTR1

Sources for Nonarteritic Anterior Ischemic Optic Neuropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
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31 HGMD
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