NAION
MCID: NNR004
MIFTS: 59

Nonarteritic Anterior Ischemic Optic Neuropathy (NAION)

Categories: Eye diseases, Genetic diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Nonarteritic Anterior Ischemic Optic Neuropathy

MalaCards integrated aliases for Nonarteritic Anterior Ischemic Optic Neuropathy:

Name: Nonarteritic Anterior Ischemic Optic Neuropathy 57 12 29 73
Anterior Ischemic Optic Neuropathy 12 53 75 15 73
Nonarteritic Anterior Ischemic Optic Neuropathy, Susceptibility to 57 29 13 6
Non-Arteritic Anterior Ischemic Optic Neuropathy 12 75 15
Naion 57 75 55
Optic Neuropathy, Ischemic 44 73
Ischemic Optic Neuropathy 12 53
Aion 53 75
Neuropathy, Optic, Ischemic, Nonarteritic Anterior, Susceptibility to 40
Optic Neuropathy, Anterior Ischemic, Susceptibility to 57
Optic Neuropathy, Anterior Ischemic 57
Naion, Susceptibility to 57

Characteristics:

OMIM:

57
Inheritance:
autosomal recessive


HPO:

32
nonarteritic anterior ischemic optic neuropathy:
Inheritance autosomal recessive inheritance


Classifications:



External Ids:

OMIM 57 258660
Disease Ontology 12 DOID:0050864 DOID:12010
ICD10 33 H47.01
ICD9CM 35 377.41
MeSH 44 D018917
SNOMED-CT 68 14357004
MedGen 42 C1847711
SNOMED-CT via HPO 69 258211005

Summaries for Nonarteritic Anterior Ischemic Optic Neuropathy

NIH Rare Diseases : 53 Anterior ischemic optic neuropathy (AION) is an eye disease characterized by infarction of the optic disk leading to vision loss. It can be nonarteritic (nonarteritic anterior ischemic optic neuropathy or NAION) or arteritic, the latter being associated with giant cell arteritis (GCA; often termed temporal arteritis).Vision loss with both varieties is typically rapid (over minutes, hours, or days) and painless. Symptoms such as a general feeling of being unwell (malaise), muscle aches and pains, headaches over the temple, pain when combing hair, pain in the jaw after chewing, and tenderness over the temporal artery (one of the major arteries of the head) may be present with giant cell arteritis. At exam, visual acuity is reduced and the optic disc is swollen. In both subtypes, visual field examination is often reduced in the inferior and central visual fields.The visual loss is usually permanent, with some recovery possibly occurring within the first weeks or months. The arteritic variety is treated with corticosteroids. Treatment of the nonarteritic variety with aspirin or corticosteroids has not been helpful. 

MalaCards based summary : Nonarteritic Anterior Ischemic Optic Neuropathy, also known as anterior ischemic optic neuropathy, is related to impotence and sleep apnea. An important gene associated with Nonarteritic Anterior Ischemic Optic Neuropathy is GP1BA (Glycoprotein Ib Platelet Subunit Alpha), and among its related pathways/superpathways are Development Angiotensin activation of ERK and Response to elevated platelet cytosolic Ca2+. The drugs Levodopa and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include eye, kidney and liver, and related phenotypes are nonarteritic anterior ischemic optic neuropathy and homeostasis/metabolism

UniProtKB/Swiss-Prot : 75 Non-arteritic anterior ischemic optic neuropathy: An ocular disease due to ischemic injury to the optic nerve. It usually affects the optic disk and leads to visual loss and optic disk swelling of a pallid nature. Visual loss is usually sudden, or over a few days at most and is usually permanent, with some recovery possibly occurring within the first weeks or months. Patients with small disks having smaller or non-existent cups have an anatomical predisposition for non-arteritic anterior ischemic optic neuropathy. As an ischemic episode evolves, the swelling compromises circulation, with a spiral of ischemia resulting in further neuronal damage.

Wikipedia : 76 Anterior ischemic optic neuropathy (AION) is a medical condition involving loss of vision caused by... more...

Description from OMIM: 258660

Related Diseases for Nonarteritic Anterior Ischemic Optic Neuropathy

Diseases related to Nonarteritic Anterior Ischemic Optic Neuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 266)
# Related Disease Score Top Affiliating Genes
1 impotence 30.9 EDN1 NOS3 PDE5A
2 sleep apnea 30.8 ACE EDN1 NOS3
3 thrombophilia 30.2 F2 F5 MTHFR SERPINC1
4 antiphospholipid syndrome 30.2 F2 F5 MTHFR SERPINC1
5 ischemic optic neuropathy 30.2 ACE AGTR1 EDN1 F2 F5 GP1BA
6 ischemia 30.1 ACE EDN1 NOS3
7 amaurosis fugax 30.1 F5 MTHFR
8 diabetes mellitus 30.1 ACE AGTR1 EDN1 NOS3
9 retinal artery occlusion 30.0 ACE F2 F5 MTHFR SERPINC1
10 pulmonary hypertension 30.0 ACE EDN1 NOS3 PDE5A
11 central retinal vein occlusion 30.0 F2 F5 MTHFR SERPINC1
12 retinal vein occlusion 30.0 F2 F5 MTHFR SERPINC1
13 carotid artery occlusion 29.9 F5 NOS3
14 branch retinal artery occlusion 29.9 F2 MTHFR SERPINC1
15 arteritic anterior ischemic optic neuropathy 29.8 ACE F2 F5 GP1BA MTHFR NOS3
16 retinal vascular occlusion 29.7 F2 F5 MTHFR SERPINC1
17 thrombosis 29.7 F2 F5 GP1BA MTHFR SERPINC1
18 malignant hypertension 29.6 ACE AGTR1 EDN1
19 microvascular complications of diabetes 5 29.5 ACE AGTR1 NOS3
20 migraine with aura 29.5 ACE F2 MTHFR NOS3
21 spinal cord infarction 29.5 F2 F5 MTHFR SERPINC1
22 atrial fibrillation 29.5 ACE AGTR1 F2
23 hellp syndrome 29.2 EDN1 F2 F5 MTHFR SERPINC1
24 vascular disease 28.6 ACE EDN1 F2 F5 GP1BA MTHFR
25 optic nerve disease 11.4
26 neuropathy 11.4
27 temporal arteritis 10.6
28 optic neuritis 10.5
29 neuritis 10.5
30 cataract 10.3
31 open-angle glaucoma 10.3
32 central retinal artery occlusion 10.3
33 refractive error 10.3
34 inferior vena cava interruption 10.2 F5 MTHFR
35 cerebral atherosclerosis 10.2 ACE MTHFR
36 catastrophic antiphospholipid syndrome 10.2 F5 MTHFR
37 3-methylglutaconic aciduria, type iii 10.2
38 myelodysplastic syndrome 10.2
39 b-cell lymphomas 10.2
40 diffuse large b-cell lymphoma 10.2
41 hepatitis 10.2
42 liver disease 10.2
43 optic disk drusen 10.2
44 acute closed-angle glaucoma 10.2
45 papilledema 10.2
46 hepatitis c 10.2
47 glucosephosphate dehydrogenase deficiency 10.2
48 macular retinal edema 10.2
49 glaucomatocyclitic crisis 10.2
50 vitreous detachment 10.2

Comorbidity relations with Nonarteritic Anterior Ischemic Optic Neuropathy via Phenotypic Disease Network (PDN):


Hypertension, Essential Temporal Arteritis

Graphical network of the top 20 diseases related to Nonarteritic Anterior Ischemic Optic Neuropathy:



Diseases related to Nonarteritic Anterior Ischemic Optic Neuropathy

Symptoms & Phenotypes for Nonarteritic Anterior Ischemic Optic Neuropathy

Symptoms via clinical synopsis from OMIM:

57
Eyes:
nonarteritic anterior ischemic optic neuropathy
papillophlebitis


Clinical features from OMIM:

258660

Human phenotypes related to Nonarteritic Anterior Ischemic Optic Neuropathy:

32
# Description HPO Frequency HPO Source Accession
1 nonarteritic anterior ischemic optic neuropathy 32 HP:0007634

MGI Mouse Phenotypes related to Nonarteritic Anterior Ischemic Optic Neuropathy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.97 ACE AGTR1 EDN1 F2 F5 GP1BA
2 cardiovascular system MP:0005385 9.91 ACE AGTR1 EDN1 F2 F5 NOS3
3 mortality/aging MP:0010768 9.76 ACE AGTR1 EDN1 F2 F5 MTHFR
4 liver/biliary system MP:0005370 9.65 ACE F5 MTHFR NOS3 SERPINC1
5 nervous system MP:0003631 9.5 AGTR1 EDN1 F2 F5 MTHFR NOS3
6 renal/urinary system MP:0005367 9.02 ACE AGTR1 EDN1 NOS3 SERPINC1

Drugs & Therapeutics for Nonarteritic Anterior Ischemic Optic Neuropathy

Drugs for Nonarteritic Anterior Ischemic Optic Neuropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 61)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Levodopa Approved Phase 4 59-92-7 6047
2
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
3
Carbidopa Approved Phase 4 28860-95-9 34359 38101
4
4-Aminopyridine Approved Phase 4 504-24-5 1727
5
Tadalafil Approved, Investigational Phase 4 171596-29-5 110635
6
Choline Approved, Nutraceutical Phase 4 62-49-7 305
7 Immunologic Factors Phase 4,Phase 3,Phase 1,Phase 2
8 Cytidine Diphosphate Choline Phase 4
9 Nootropic Agents Phase 4
10 Neurotransmitter Agents Phase 4,Phase 1
11 Antiparkinson Agents Phase 4
12 Aromatic Amino Acid Decarboxylase Inhibitors Phase 4
13 Dopamine agonists Phase 4
14 Adjuvants, Immunologic Phase 4
15 Dopamine Agents Phase 4
16 Carbidopa, levodopa drug combination Phase 4
17 Potassium Channel Blockers Phase 4
18 Sildenafil Citrate Phase 4 171599-83-0
19 Phosphodiesterase Inhibitors Phase 4
20 Phosphodiesterase 5 Inhibitors Phase 4
21 Vardenafil Dihydrochloride Phase 4
22
Methylprednisolone Approved, Vet_approved Phase 3,Phase 2 83-43-2 6741
23
Prednisolone Approved, Vet_approved Phase 3,Phase 2 50-24-8 5755
24
Prednisolone phosphate Approved, Vet_approved Phase 3,Phase 2 302-25-0
25
Methylprednisolone hemisuccinate Approved Phase 3,Phase 2 2921-57-5
26
Triamcinolone Approved, Vet_approved Phase 3,Phase 1,Phase 2 124-94-7 31307
27
Prednisolone hemisuccinate Experimental Phase 3,Phase 2 2920-86-7
28 Hormone Antagonists Phase 3,Phase 1,Phase 2
29 Antineoplastic Agents, Hormonal Phase 3,Phase 2
30 Autonomic Agents Phase 3,Phase 2
31 glucocorticoids Phase 3,Phase 1,Phase 2
32 Hormones Phase 3,Phase 1,Phase 2
33 Neuroprotective Agents Phase 3,Phase 2,Phase 1
34 Methylprednisolone acetate Phase 3,Phase 2
35 Prednisolone acetate Phase 3,Phase 2
36 Antiemetics Phase 3,Phase 2
37 Peripheral Nervous System Agents Phase 3,Phase 2
38 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 1,Phase 2
39 Protective Agents Phase 3,Phase 2
40 Gastrointestinal Agents Phase 3,Phase 2
41 Anti-Inflammatory Agents Phase 3,Phase 1,Phase 2
42 Immunosuppressive Agents Phase 3,Phase 1,Phase 2
43 triamcinolone acetonide Phase 3,Phase 1,Phase 2
44 Triamcinolone hexacetonide Phase 3,Phase 1,Phase 2
45 Triamcinolone diacetate Phase 3,Phase 1,Phase 2
46 Mastic Phase 3
47 Butylated Hydroxytoluene Phase 3
48
Bevacizumab Approved, Investigational Phase 1, Phase 2,Phase 2 216974-75-3
49 Angiogenesis Modulating Agents Phase 1, Phase 2,Phase 2
50 Angiogenesis Inhibitors Phase 1, Phase 2,Phase 2

Interventional clinical trials:

(show all 22)
# Name Status NCT ID Phase Drugs
1 Citicoline Effect on Non-arteritic Anterior Ischemic Optic Neuropathy (NAION) Completed NCT03046693 Phase 4 Group A Citicoline 1000 mg oral tablet;Group B placebo oral tablet
2 Effect of Levodopa-Carbidopa on Visual Function in Patients With Recent-Onset Nonarteritic Anterior Ischemic Optic Neuropathy Completed NCT00432393 Phase 4 levodopa-carbidopa
3 A New Medicine to Treat Nonarteritic Anterior Ischemic Optic Neuropathy (NAION) Completed NCT01975324 Phase 4 dalfampridine;Placebo
4 PDE5 Inhibitor Use and Non-arteritic Anterior Ischemic Optic Neuropathy (NAION) Terminated NCT00867815 Phase 4 Diagnostic procedures
5 Outcomes of Steroid and Oxygen Therapy Versus Placebo Therapy in Non-arteritic Anterior Ischemic Optic Neuropathy Unknown status NCT02439866 Phase 3 placebo;Intravenous methylprednisolone;normobaric oxygen with face mask
6 Retrobulbar Triamcinolone Acetonide Injection in the Treatment of NA-AION Unknown status NCT02329288 Phase 3 Triamcinolone Acetonide;placebo
7 Phase 2/3, Randomized, Double-Masked, Sham-Controlled Trial of QPI-1007 in Subjects With Acute Nonarteritic Anterior Ischemic Optic Neuropathy (NAION) Recruiting NCT02341560 Phase 2, Phase 3 QPI-1007 Injection - 1.5 mg;QPI-1007 Injection - 3.0 mg
8 Efficacy & Safety of RPh201 Treatment in Patients With Previous Nonarteritic Anterior Ischemic Optic Neuropathy (NAION) Recruiting NCT03547206 Phase 3 RPh201
9 Comparison of Intravitreal Bevacizumab and Triamcinolone With Placebo Unknown status NCT01330524 Phase 1, Phase 2 Avastin and Triamcinolone
10 Intravitreal Bevacizumab for Non-Arteritic Anterior Ischemic Optic Neuropathy Unknown status NCT00813059 Phase 2 Intra-vitreal injection of bevacizumab (1.25mg/0.05ml)
11 Safety Assessment of Intravitreal Mesenchymal Stem Cells for Acute Non Arteritic Anterior Ischemic Optic Neuropathy Recruiting NCT03173638 Phase 2
12 NAION Treatment With Oral Prednisolone and Erythropoietin Injection Recruiting NCT03715881 Phase 2 Oral prednisolone administration 50 mg;Intravenous Erythropoietin injection
13 A Phase I Clinical Trial of DARC Unknown status NCT02394613 Phase 1 ANX776
14 Safety Study of a Single IVT Injection of QPI-1007 in Chronic Optic Nerve Atrophy and Recent Onset NAION Patients Completed NCT01064505 Phase 1 QPI-1007 at various doses
15 Ranibizumab Therapy for Non-arteritic Ischemic Optic Neuropathy Completed NCT00561834 Phase 1 ranibizumab
16 Treatment Study for Ischemic Optic Neuropathy With Opthalmic Timolol Maleate 0.5% Withdrawn NCT01607671 Phase 1 Timolol maleate
17 Vision Restoration Therapy (VRT) to Treat Non-Arteritic Anterior Ischemic Optic Neuropathy Completed NCT00140491 Not Applicable
18 A Study to Determine if There is a Possible Association Between NAION and Phosphodiesterase Type 5 (PDE5) Inhibitors Completed NCT01131104 PDE5 Inhibitors
19 Epidemiology Study of Non-arteritic Anterior Ischemic Optic Neuropathy (NAION) Completed NCT01260324
20 Electric Stimulation of the Eye to Improve Vision After Trauma Completed NCT02019927 Not Applicable
21 Retinal Neuro-vascular Coupling in Patients With Non-arteritic Anterior Ischemic Optic Neuropathy Recruiting NCT03401892 Not Applicable
22 OCT Angiography in Arteritic and Non Arteritic Anterior Ischemic Neuropathy Recruiting NCT03642899

Search NIH Clinical Center for Nonarteritic Anterior Ischemic Optic Neuropathy

Cochrane evidence based reviews: optic neuropathy, ischemic

Genetic Tests for Nonarteritic Anterior Ischemic Optic Neuropathy

Genetic tests related to Nonarteritic Anterior Ischemic Optic Neuropathy:

# Genetic test Affiliating Genes
1 Nonarteritic Anterior Ischemic Optic Neuropathy, Susceptibility to 29 GP1BA
2 Nonarteritic Anterior Ischemic Optic Neuropathy 29

Anatomical Context for Nonarteritic Anterior Ischemic Optic Neuropathy

MalaCards organs/tissues related to Nonarteritic Anterior Ischemic Optic Neuropathy:

41
Eye, Kidney, Liver, Heart, B Cells, Spinal Cord, Placenta

Publications for Nonarteritic Anterior Ischemic Optic Neuropathy

Articles related to Nonarteritic Anterior Ischemic Optic Neuropathy:

(show top 50) (show all 578)
# Title Authors Year
1
Hyperhomocysteinemia in bilateral anterior ischemic optic neuropathy after conventional coronary artery bypass graft: a case report. ( 29338755 )
2018
2
Pseudohemangioma in Nonarteritic Anterior Ischemic Optic Neuropathy. ( 29784095 )
2018
3
Quantitative analysis of optical coherence tomographic angiography (OCT-A) in patients with non-arteritic anterior ischemic optic neuropathy (NAION) corresponds to visual function. ( 29953490 )
2018
4
Could Buerger's disease cause nonarteritic anterior ischemic optic neuropathy?: a rare case report. ( 29623524 )
2018
5
Retinal and Choroidal Microvasculature in Nonarteritic Anterior Ischemic Optic Neuropathy: An Optical Coherence Tomography Angiography Study. ( 29490340 )
2018
6
Intravitreal Triamcinolone Acetonide Injection in a Rodent Model of Anterior Ischemic Optic Neuropathy. ( 29521709 )
2018
7
Acute Effect of Hypervolemic Hemodilution on Retrobulbar Hemodynamics in Anterior Ischemic Optic Neuropathy. ( 29546060 )
2018
8
The polymorphisms of ATOH 7, ET-1 and ACE in non-arteritic anterior ischemic optic neuropathy. ( 29792847 )
2018
9
Anomalous coagulation factors in non-arteritic anterior ischemic optic neuropathy with central retinal vein occlusion: A case report. ( 29642215 )
2018
10
The Association Between Phosphodiesterase Type 5 Inhibitor Use and Risk of Non-Arteritic Anterior Ischemic Optic Neuropathy: A Systematic Review and Meta-Analysis. ( 29884471 )
2018
11
Risk of Ischemic Kidney Injury in Patients With Nonarteritic Anterior Ischemic Optic Neuropathy: A Nationwide Population-based Study. ( 29330063 )
2018
12
Steroids versus No Steroids in Nonarteritic Anterior Ischemic Optic Neuropathy: A Randomized Controlled Trial. ( 29705054 )
2018
13
Optical Coherence Tomography Angiography of the Peripapillary Retina in Normal-Tension Glaucoma and Chronic Nonarteritic Anterior Ischemic Optic Neuropathy. ( 29451992 )
2018
14
Structural changes of macula and optic disk of the fellow eye in patients with nonarteritic anterior ischemic optic neuropathy. ( 29749568 )
2018
15
Three-Dimensional High-Resolution Black-Blood Magnetic Resonance Imaging for Detection of Arteritic Anterior Ischemic Optic Neuropathy in Patients With Giant Cell Arteritis. ( 30095558 )
2018
16
Giant Cell Arteritis Associated Arteritic Anterior Ischemic Optic Neuropathy: Sudden Vision Loss on the Contralateral Side of Headache. ( 30198237 )
2018
17
Non-Arteritic Anterior Ischemic Optic Neuropathy in Pilots. ( 30352654 )
2018
18
Non-arteritic anterior ischemic optic neuropathy - Case report. ( 30505994 )
2018
19
Anterior Ischemic Optic Neuropathy Due to Calciphylaxis. ( 29016409 )
2018
20
Cilioretinal artery occlusion and anterior ischemic optic neuropathy as the initial presentation in a child female carrier of Fabry disease. ( 28281207 )
2018
21
Lamina cribrosa position and Bruch's membrane opening differences between anterior ischemic optic neuropathy and open-angle glaucoma. ( 29911429 )
2018
22
Optical coherence tomography angiography in acute unilateral nonarteritic anterior ischemic optic neuropathy: A comparison with the fellow eye and with eyes with papilledema. ( 30038161 )
2018
23
Spectral-Domain Optical Coherence Tomography of the Vitreopapillary Interface in Acute Nonarteritic Anterior Ischemic Optic Neuropathy. ( 30098345 )
2018
24
Anterior Ischemic Optic Neuropathy After Dental Extraction. ( 30179990 )
2018
25
Peripapillary retinal nerve fiber layer and macular ganglion cell complex thickness in patients with chronic phase of nonarteritic anterior ischemic optic neuropathy. ( 30206557 )
2018
26
Anterior Ischemic Optic Neuropathy in a Patient with Erectile Dysfunction: Tadalafil as an Offending Medication. ( 30211242 )
2018
27
Systemic-Related Factors of Nonarteritic Anterior Ischemic Optic Neuropathy. ( 30246725 )
2018
28
A Small Molecule TrkB Neurotrophin Receptor Partial Agonist as Possible Treatment for Experimental Nonarteritic Anterior Ischemic Optic Neuropathy. ( 30273053 )
2018
29
Risk Factors for Fellow Eye Involvement in Nonarteritic Anterior Ischemic Optic Neuropathy. ( 30300257 )
2018
30
Giant cell arteritis presenting as bilateral anterior ischemic optic neuropathy: a biopsy-proven case report in Chinese patient. ( 30376812 )
2018
31
Sequential nonarteritic anterior ischemic optic neuropathy in patient on chronic hemodialysis. ( 30460468 )
2018
32
A rodent model of anterior ischemic optic neuropathy (AION) based on laser photoactivation of verteporfin. ( 30466418 )
2018
33
Optic nerve head width and retinal nerve fiber layer changes are good indexes for validating the successful induction of experimental anterior ischemic optic neuropathy. ( 30557569 )
2018
34
The Effect of Combined Systemic Erythropoietin and Steroid on Non-arteritic Anterior Ischemic Optic Neuropathy: A Prospective Study. ( 28632028 )
2017
35
Increased Risk of Stroke in Patients With Nonarteritic Anterior Ischemic Optic Neuropathy: A Nationwide Retrospective CohortA Study. ( 28063480 )
2017
36
High-dose intravenous pulse steroid therapy for optic disc swelling and subretinal fluid in non-arteritic anterior ischemic optic neuropathy. ( 28303068 )
2017
37
New Treatments for Nonarteritic Anterior Ischemic Optic Neuropathy. ( 27886887 )
2017
38
Structure-Function Analysis of Nonarteritic Anterior Ischemic Optic Neuropathy and Age-Related Differences in Outcome. ( 28538035 )
2017
39
Retinal Vessel Density in Optical Coherence Tomography Angiography in Optic Atrophy after Nonarteritic Anterior Ischemic Optic Neuropathy. ( 28316838 )
2017
40
Optical coherence tomography angiography in acute arteritic and non-arteritic anterior ischemic optic neuropathy. ( 28861697 )
2017
41
Takayasu arteritis presenting as isolated anterior ischemic optic neuropathy. ( 28389774 )
2017
42
Corticosteroid Therapy in Nonarteritic Anterior Ischemic Optic Neuropathy. ( 28759499 )
2017
43
Comparison of the Retinal Microvascular Density Between Open Angle Glaucoma and Nonarteritic Anterior Ischemic Optic Neuropathy. ( 28687846 )
2017
44
Atrial fibrillation in retinal vascular occlusion disease and non-arteritic anterior ischemic optic neuropathy. ( 28771491 )
2017
45
Assessment of nonarteritic anterior ischemic optic neuropathy with intravoxel incoherent motion diffusion-weighted imaging using readout-segmented echo-planar imaging, parallel imaging, and 2D navigator-based reacquisition. ( 28513892 )
2017
46
Microvasculature dropout detected by the optical coherence tomography angiography in nonarteritic anterior ischemic optic neuropathy. ( 28986994 )
2017
47
Bilateral Arteritic Anterior Ischemic Optic Neuropathy Associated with Giant Cell Arteritis in Korea. ( 28994270 )
2017
48
Comparison of Optic Nerve Head Morphology in Patients with Primary Open Angle Glaucoma and Non-Arteritic Anterior Ischemic Optic Neuropathy. ( 29485789 )
2017
49
Corticosteroid Therapy in Nonarteritic Anterior Ischemic Optic Neuropathy: Response. ( 28759500 )
2017
50
Visual outcome following bilateral non-arteritic anterior ischemic optic neuropathy: a systematic review and meta-analysis. ( 28836961 )
2017

Variations for Nonarteritic Anterior Ischemic Optic Neuropathy

ClinVar genetic disease variations for Nonarteritic Anterior Ischemic Optic Neuropathy:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 GP1BA GP1BA, 92-BP DUP, SER399-THR411 DUP, VARIABLE REPEATS duplication risk factor
2 GP1BA NM_000173.6(GP1BA): c.256C> T (p.Leu86Phe) single nucleotide variant Likely benign rs13306411 GRCh38 Chromosome 17, 4932860: 4932860
3 GP1BA NM_000173.6(GP1BA): c.256C> T (p.Leu86Phe) single nucleotide variant Likely benign rs13306411 GRCh37 Chromosome 17, 4836155: 4836155

Expression for Nonarteritic Anterior Ischemic Optic Neuropathy

Search GEO for disease gene expression data for Nonarteritic Anterior Ischemic Optic Neuropathy.

Pathways for Nonarteritic Anterior Ischemic Optic Neuropathy

Pathways related to Nonarteritic Anterior Ischemic Optic Neuropathy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.52 AGTR1 EDN1 F2 NOS3
2
Show member pathways
12.51 F2 F5 GP1BA NOS3 PDE5A SERPINC1
3 11.69 F2 F5 SERPINC1
4 11.43 AGTR1 EDN1 NOS3
5
Show member pathways
11.23 ACE AGTR1 NOS3
6
Show member pathways
11.13 F2 F5 GP1BA SERPINC1
7
Show member pathways
11.06 NOS3 PDE5A
8 10.94 EDN1 NOS3
9 10.44 NOS3 PDE5A

GO Terms for Nonarteritic Anterior Ischemic Optic Neuropathy

Cellular components related to Nonarteritic Anterior Ischemic Optic Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.1 ACE EDN1 F2 F5 GP1BA SERPINC1

Biological processes related to Nonarteritic Anterior Ischemic Optic Neuropathy according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 cell surface receptor signaling pathway GO:0007166 9.77 EDN1 F2 GP1BA
2 cellular protein metabolic process GO:0044267 9.74 F2 F5 SERPINC1
3 blood circulation GO:0008015 9.58 F5 MTHFR
4 response to amino acid GO:0043200 9.58 EDN1 MTHFR
5 blood vessel remodeling GO:0001974 9.56 ACE NOS3
6 blood coagulation GO:0007596 9.56 F2 F5 GP1BA SERPINC1
7 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway GO:0051482 9.55 AGTR1 EDN1
8 positive regulation of reactive oxygen species metabolic process GO:2000379 9.54 AGTR1 F2
9 positive regulation of cardiac muscle hypertrophy GO:0010613 9.52 EDN1 PDE5A
10 fibrinolysis GO:0042730 9.51 F2 GP1BA
11 regulation of blood pressure GO:0008217 9.5 ACE EDN1 NOS3
12 regulation of blood vessel size GO:0050880 9.49 EDN1 NOS3
13 blood coagulation, intrinsic pathway GO:0007597 9.48 F2 GP1BA
14 regulation of blood vessel diameter GO:0097746 9.46 ACE AGTR1
15 negative regulation of platelet activation GO:0010544 9.43 F2 NOS3
16 regulation of systemic arterial blood pressure by endothelin GO:0003100 9.4 EDN1 NOS3
17 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 9.37 ACE AGTR1
18 regulation of vasoconstriction GO:0019229 9.33 ACE AGTR1 EDN1
19 regulation of blood coagulation GO:0030193 9.13 F2 GP1BA SERPINC1
20 hemostasis GO:0007599 8.92 F2 F5 GP1BA SERPINC1

Molecular functions related to Nonarteritic Anterior Ischemic Optic Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 NADP binding GO:0050661 8.96 MTHFR NOS3
2 bradykinin receptor binding GO:0031711 8.62 ACE AGTR1

Sources for Nonarteritic Anterior Ischemic Optic Neuropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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