NAION
MCID: NNR004
MIFTS: 57

Nonarteritic Anterior Ischemic Optic Neuropathy (NAION)

Categories: Cardiovascular diseases, Eye diseases, Genetic diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Nonarteritic Anterior Ischemic Optic Neuropathy

MalaCards integrated aliases for Nonarteritic Anterior Ischemic Optic Neuropathy:

Name: Nonarteritic Anterior Ischemic Optic Neuropathy 57 12 29 37 70
Anterior Ischemic Optic Neuropathy 12 20 72 15 17 70
Nonarteritic Anterior Ischemic Optic Neuropathy, Susceptibility to 57 29 13 6
Non-Arteritic Anterior Ischemic Optic Neuropathy 12 72 15
Naion 57 72 54
Optic Neuropathy, Ischemic 44 70
Ischemic Optic Neuropathy 12 20
Aion 20 72
Neuropathy, Optic, Ischemic, Nonarteritic Anterior, Susceptibility to 39
Optic Neuropathy, Anterior Ischemic, Susceptibility to 57
Non-Arteritic Anterior Ischaemic Optic Neuropathy 12
Nonarteritic Anterior Ischaemic Optic Neuropathy 12
Optic Neuropathy, Anterior Ischemic 57
Naion, Susceptibility to 57

Characteristics:

OMIM®:

57 (Updated 05-Apr-2021)
Inheritance:
autosomal recessive


HPO:

31
nonarteritic anterior ischemic optic neuropathy:
Inheritance autosomal recessive inheritance


Classifications:



External Ids:

Disease Ontology 12 DOID:0050864 DOID:12010
OMIM® 57 258660
ICD9CM 34 377.41
MeSH 44 D018917
SNOMED-CT 67 14357004
ICD10 32 H47.01
MedGen 41 C1847711
SNOMED-CT via HPO 68 258211005
UMLS 70 C0155305 C0751711 C1852242

Summaries for Nonarteritic Anterior Ischemic Optic Neuropathy

GARD : 20 Anterior ischemic optic neuropathy (AION) is an eye disease characterized by infarction of the optic disk leading to vision loss. It can be nonarteritic (nonarteritic anterior ischemic optic neuropathy or NAION) or arteritic, the latter being associated with giant cell arteritis (GCA; often termed temporal arteritis). Vision loss with both varieties is typically rapid (over minutes, hours, or days) and painless. Symptoms such as a general feeling of being unwell (malaise), muscle aches and pains, headaches over the temple, pain when combing hair, pain in the jaw after chewing, and tenderness over the temporal artery (one of the major arteries of the head) may be present with giant cell arteritis. At exam, visual acuity is reduced and the optic disc is swollen. In both subtypes, visual field examination is often reduced in the inferior and central visual fields. The visual loss is usually permanent, with some recovery possibly occurring within the first weeks or months. The arteritic variety is treated with corticosteroids. Treatment of the nonarteritic variety with aspirin or corticosteroids has not been helpful.

MalaCards based summary : Nonarteritic Anterior Ischemic Optic Neuropathy, also known as anterior ischemic optic neuropathy, is related to impotence and compartment syndrome. An important gene associated with Nonarteritic Anterior Ischemic Optic Neuropathy is GP1BA (Glycoprotein Ib Platelet Subunit Alpha), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Pathways in cancer. The drugs 4-Aminopyridine and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include eye, bone marrow and retina, and related phenotypes are nonarteritic anterior ischemic optic neuropathy and homeostasis/metabolism

UniProtKB/Swiss-Prot : 72 Non-arteritic anterior ischemic optic neuropathy: An ocular disease due to ischemic injury to the optic nerve. It usually affects the optic disk and leads to visual loss and optic disk swelling of a pallid nature. Visual loss is usually sudden, or over a few days at most and is usually permanent, with some recovery possibly occurring within the first weeks or months. Patients with small disks having smaller or non-existent cups have an anatomical predisposition for non-arteritic anterior ischemic optic neuropathy. As an ischemic episode evolves, the swelling compromises circulation, with a spiral of ischemia resulting in further neuronal damage.

Wikipedia : 73 Anterior ischemic optic neuropathy (AION) is a medical condition involving loss of vision caused by... more...

More information from OMIM: 258660

Related Diseases for Nonarteritic Anterior Ischemic Optic Neuropathy

Diseases related to Nonarteritic Anterior Ischemic Optic Neuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 573)
# Related Disease Score Top Affiliating Genes
1 impotence 31.4 PDE5A NOS3 EDN1 ACE
2 compartment syndrome 31.1 SERPINC1 F2 CRP
3 arteritic anterior ischemic optic neuropathy 31.0 NOS3 MTHFR GP1BA F5 F2 ACE
4 thrombophilia 31.0 SERPINC1 MTHFR F5 F2 APOH
5 amaurosis fugax 30.9 MTHFR F5
6 takayasu arteritis 30.6 MTHFR EDN1 CRP
7 intraocular pressure quantitative trait locus 30.5 VEGFA POU4F1 EDN1 CNTF
8 optic nerve disease 30.5 VEGFA POU4F1 PDE5A OPN4 EDN1 CRP
9 thrombophilia due to activated protein c resistance 30.5 SERPINC1 MTHFR F5 F2 APOH
10 neuroretinitis 30.4 CRP ACE
11 carotid artery occlusion 30.4 NOS3 F5 APOH
12 raynaud phenomenon 30.4 EDN1 APOH
13 protein s deficiency 30.4 SERPINC1 MTHFR F5 F2 APOH
14 thrombophilia due to thrombin defect 30.4 SERPINC1 MTHFR F5 F2 APOH
15 open-angle glaucoma 30.3 VEGFA NOS3 MTHFR EDN1 ACE
16 antiphospholipid syndrome 30.3 SERPINC1 MTHFR F5 F2 CRP APOH
17 arteriosclerosis 30.3 SERPINC1 NOS3 GP1BA EDN1 CRP ACE
18 iridocyclitis 30.3 VEGFA CRP ACE
19 cavernous sinus thrombosis 30.3 SERPINC1 F2 CRP
20 sickle cell disease 30.3 NOS3 G6PD EDN1
21 epidural abscess 30.2 F2 CRP
22 glaucoma, primary open angle 30.2 VEGFA POU4F1 EDN1
23 optic papillitis 30.2 CRP ACE
24 ischemic neuropathy 30.2 VEGFA POU4F1 CNTF
25 malignant hypertension 30.2 EDN1 AGTR1 AGT ACE
26 intracranial hypertension 30.1 SERPINC1 MTHFR F5 F2 APOH
27 sleep disorder 30.1 OPN4 EDN1 CRP ACE
28 retinal vascular disease 30.1 VEGFA NOS3 MTHFR ACE
29 microvascular complications of diabetes 5 30.1 VEGFA NOS3 AGTR1 AGT ACE
30 cranial nerve palsy 30.1 SERPINC1 CRP ACE
31 atrial fibrillation 30.1 F2 CRP AGTR1 AGT ACE
32 sleep apnea 30.1 VEGFA NOS3 EDN1 CRP AGT ACE
33 branch retinal artery occlusion 30.0 VEGFA SERPINC1 MTHFR F2 CRP APOH
34 central retinal artery occlusion 30.0 VEGFA SERPINC1 MTHFR F2 EDN1 CRP
35 spinal cord infarction 30.0 SERPINC1 MTHFR F5 F2 APOH
36 papilledema 29.9 VEGFA SERPINC1 F2 CRP APOH ACE
37 optic nerve hypoplasia, bilateral 29.9 POU4F1 OPN4 EDN1 CNTF
38 venous insufficiency 29.9 VEGFA MTHFR F5 F2 CRP
39 retinal ischemia 29.9 VEGFA POU4F1 CNTF CASP2
40 thrombocytosis 29.8 SERPINC1 F2 CRP
41 migraine with aura 29.8 NOS3 MTHFR F5 F2 EDN1 ACE
42 thrombosis 29.8 SERPINC1 MTHFR GP1BA F5 F2 APOH
43 cerebrovascular disease 29.8 MTHFR GP1BA F5 F2 CRP APOH
44 deficiency anemia 29.7 SERPINC1 GP1BA G6PD F5 F2 CRP
45 homocysteinemia 29.7 SERPINC1 NOS3 MTHFR F5 F2 CRP
46 ischemia 29.7 VEGFA PDE5A NOS3 GP1BA EDN1 ACE
47 apnea, obstructive sleep 29.7 VEGFA NOS3 EDN1 CRP AGT ACE
48 polycythemia 29.7 VEGFA SERPINC1 F5 F2 EDN1 ACE
49 polycystic kidney disease 29.7 VEGFA NOS3 EDN1 AGTR1 AGT ACE
50 carotid stenosis 29.7 VEGFA NOS3 MTHFR CRP ACE

Comorbidity relations with Nonarteritic Anterior Ischemic Optic Neuropathy via Phenotypic Disease Network (PDN):


Hypertension, Essential Temporal Arteritis

Graphical network of the top 20 diseases related to Nonarteritic Anterior Ischemic Optic Neuropathy:



Diseases related to Nonarteritic Anterior Ischemic Optic Neuropathy

Symptoms & Phenotypes for Nonarteritic Anterior Ischemic Optic Neuropathy

Human phenotypes related to Nonarteritic Anterior Ischemic Optic Neuropathy:

31
# Description HPO Frequency HPO Source Accession
1 nonarteritic anterior ischemic optic neuropathy 31 HP:0007634

Symptoms via clinical synopsis from OMIM®:

57 (Updated 05-Apr-2021)
Eyes:
nonarteritic anterior ischemic optic neuropathy
papillophlebitis

Clinical features from OMIM®:

258660 (Updated 05-Apr-2021)

MGI Mouse Phenotypes related to Nonarteritic Anterior Ischemic Optic Neuropathy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.06 ACE AGT AGTR1 APOH CNTF CRP
2 cardiovascular system MP:0005385 10 ACE AGT AGTR1 CRP EDN1 F2
3 mortality/aging MP:0010768 9.8 ACE AGT AGTR1 APOH CASP2 EDN1
4 nervous system MP:0003631 9.53 ACE AGT AGTR1 CASP2 CNTF EDN1

Drugs & Therapeutics for Nonarteritic Anterior Ischemic Optic Neuropathy

Drugs for Nonarteritic Anterior Ischemic Optic Neuropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 77)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
4-Aminopyridine Approved Phase 4 504-24-5 1727
2
Dopamine Approved Phase 4 62-31-7, 51-61-6 681
3
Carbidopa Approved Phase 4 28860-95-9 34359
4
Levodopa Approved Phase 4 59-92-7 6047
5
Tadalafil Approved, Investigational Phase 4 171596-29-5 110635
6
Choline Approved, Nutraceutical Phase 4 62-49-7 305
7 Cytidine Diphosphate Choline Phase 4
8 Nootropic Agents Phase 4
9 Neurotransmitter Agents Phase 4
10 Potassium Channel Blockers Phase 4
11 Dopamine Agents Phase 4
12 Adjuvants, Immunologic Phase 4
13 Dopamine agonists Phase 4
14 Immunologic Factors Phase 4
15 Carbidopa, levodopa drug combination Phase 4
16 Aromatic Amino Acid Decarboxylase Inhibitors Phase 4
17 Antiparkinson Agents Phase 4
18 Phosphodiesterase 5 Inhibitors Phase 4
19 Sildenafil Citrate Phase 4 171599-83-0
20 Vardenafil Dihydrochloride Phase 4
21
Triamcinolone Approved, Vet_approved Phase 3 124-94-7 31307
22
Bosentan Approved, Investigational Phase 3 147536-97-8 104865
23 Hormone Antagonists Phase 3
24 glucocorticoids Phase 3
25 Hormones Phase 3
26 Antineoplastic Agents, Hormonal Phase 3
27 Anti-Inflammatory Agents Phase 3
28 Gastrointestinal Agents Phase 3
29 Protective Agents Phase 3
30 Antiemetics Phase 3
31 Antihypertensive Agents Phase 3
32 Triamcinolone diacetate Phase 3
33 Triamcinolone hexacetonide Phase 3
34 triamcinolone acetonide Phase 3
35 Immunosuppressive Agents Phase 3
36 Endothelin Receptor Antagonists Phase 3
37
Bevacizumab Approved, Investigational Phase 2 216974-75-3
38
Alprostadil Approved, Investigational Phase 2 745-65-3 149351 5280723
39
Prednisolone acetate Approved, Vet_approved Phase 2 52-21-1
40
Prednisolone Approved, Vet_approved Phase 2 50-24-8 5755
41
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 6741
42
Prednisolone phosphate Approved, Vet_approved Phase 2 302-25-0
43
Methylprednisolone hemisuccinate Approved Phase 2 2921-57-5
44
Aspirin Approved, Vet_approved Phase 2 50-78-2 2244
45
Prednisone Approved, Vet_approved Phase 2 53-03-2 5865
46
Prednisolone hemisuccinate Experimental Phase 2 2920-86-7
47 Angiogenesis Inhibitors Phase 2
48 Platelet Aggregation Inhibitors Phase 2
49 Epoetin alfa Phase 2 113427-24-0
50 Hematinics Phase 2

Interventional clinical trials:

(show all 43)
# Name Status NCT ID Phase Drugs
1 Citicoline Effect on Non-arteritic Anterior Ischemic Optic Neuropathy (NAION) : Pattern Electroretinography Study Completed NCT03046693 Phase 4 Group A Citicoline 1000 mg oral tablet;Group B placebo oral tablet
2 Dalfampridine Treatment for Nonarteritic Anterior Ischemic Optic Neuropathy (NAION) Completed NCT01975324 Phase 4 dalfampridine;Placebo
3 Effect of Levodopa-Carbidopa on Visual Function in Patients With Recent-Onset Nonarteritic Anterior Ischemic Optic Neuropathy Completed NCT00432393 Phase 4 levodopa-carbidopa
4 Phase 4 Study of Evaluation of Neural Conduction Along the Visual Pathways Before and After Oral Treatment With Citicoline in Patients With Optic Nerve Diseases Completed NCT00404729 Phase 4 Citicoline
5 Prospective Case Crossover Study to Assess Whether PDE5 Inhibitor Exposure in Men Increases the Risk for the Development of Non-arteritic Anterior Ischemic Optic Neuropathy (NAION) Terminated NCT00867815 Phase 4 Diagnostic procedures
6 The Effect of High Dose Steroid and Normobaric Oxygen Therapy on Recent Onset Non-arteritic Anterior Ischemic Optic Neuropathy(NAION); a Randomized Clinical Trial Unknown status NCT02439866 Phase 3 placebo;Intravenous methylprednisolone;normobaric oxygen with face mask
7 Retrobulbar Triamcinolone Acetonide Injection in the Treatment of Nonarteritic Anterior Ischemic Optic Neuropathy Unknown status NCT02329288 Phase 3 Triamcinolone Acetonide;placebo
8 Effect of Bosentan in Patients With Non Arteritic Ischemic Optic Neuropathy Unknown status NCT02377271 Phase 3 bosentan;placebo
9 Ischemic Optic Neuropathy Decompression Trial (IONDT) Completed NCT00000127 Phase 3
10 A Phase 2/3, Randomized, Double-Masked, Sham-Controlled Trial of QPI-1007 Delivered By Single or Multi-Dose Intravitreal Injection(s) to Subjects With Acute Nonarteritic Anterior Ischemic Optic Neuropathy (NAION) Terminated NCT02341560 Phase 2, Phase 3 QPI-1007 Injection - 1.5 mg;QPI-1007 Injection - 3.0 mg
11 Scientific Title: Efficacy of Oral Prednisolone and Erythropoietin Injection in Treatment of Acute Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION) Unknown status NCT03715881 Phase 2 Oral prednisolone administration 50 mg;Intravenous Erythropoietin injection
12 Intravitreal Bevacizumab for Treatment of the Second Eye With Non-Arteritic Ischemic Optic Neuropathy Unknown status NCT00813059 Phase 2 Intra-vitreal injection of bevacizumab (1.25mg/0.05ml)
13 Comparison of Intravitreal Bevacizumab and Triamcinolone With Placebo in Acute Nonarteritic Anterior Ischemic Optic Neuropathy Unknown status NCT01330524 Phase 1, Phase 2 Avastin and Triamcinolone
14 Prospective, Unicentric, Randomized, Parallel, Double-blind, Placebo-controlled Phase II Clinical Trial to Evaluate Intravenous Infusion of Prostaglandins as Therapy in Patients With Anterior Non-arteritic Ischemic Optic Neuropathy Unknown status NCT03851562 Phase 2 Alprostadil 20 micrograms;Placebo
15 Neurotomy of Optic Nerve in Non-Arthritic Anterior Ischemic Optic Neuropathy Completed NCT00372021 Phase 1, Phase 2
16 A Preliminary Double Blind Clinical Study, Efficacy Study of RPh201 Treatment of Ischemic Optic Neuropathy (ION). Completed NCT02045212 Phase 2 RPh201;Placebo
17 Phase II Safety Assessment of Intravitreal Injection of Mesenchymal Stem Cells for Acute Non Arteritic Anterior Ischemic Optic Neuropathy (NAION) Recruiting NCT03173638 Phase 2
18 Open Label Phase II Randomized Non-comparative Study of SC Tocilizumab Associated With IV Pulse Steroid Versus IV Pulse Steroid Alone for the Treatment of Acute Anterior Ischemic Optic Neuropathy Associated With Giant Cell Arteritis Not yet recruiting NCT04239196 Phase 2 tocilizumab and IV steroids combination
19 A Double-Masked Clinical Study Evaluating the Efficacy and Safety of RPh201 Treatment in Participants With Previous NAION Terminated NCT03547206 Phase 2 RPh201 Cohort A;RPh201 Cohort B
20 A Phase I, Storer Design, Open-label, Cross-sectional, Single Site Trial of ANX776 in Healthy Volunteers, Progressive Glaucoma/Glaucoma-suspect/Ocular Hypertensive Subjects and Non-arteritic Anterior Ischaemic Optic Neuropathy Subjects Unknown status NCT02394613 Phase 1 ANX776
21 Ranibizumab Therapy for Non-arteritic Ischemic Optic Neuropathy (NAION) Completed NCT00561834 Phase 1 ranibizumab
22 A Phase I Open-Label, Dose Escalation Trial of QPI-1007 Delivered by a Single Intravitreal Injection to Patients With Optic Nerve Atrophy (Stratum I) and Acute Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION) (Stratum II) Completed NCT01064505 Phase 1 QPI-1007 at various doses
23 NT-501 CNTF Implant for Ischemic Optic Neuropathy: Safety, Neuroprotection and Neuroenhancement Completed NCT01411657 Phase 1 NT-501 CNTF Implant
24 Can Urgent Reduction of Intraocular Pressure With Ophthalmic Timolol Improve Recovery From Non-arteritic Anterior Ischemic Optic Neuropathy (NAION): a Randomized Study. Withdrawn NCT01607671 Phase 1 Timolol maleate
25 Study of the Effect of EECP on Anterior Ischemic Optic Neuropathy Unknown status NCT01768260 Aspirin
26 Ischemic Optic Neuropathy Decompression Trial Followup (IONDT Followup) Unknown status NCT00000126
27 The Detection and Epidemiology of NAION in a Commercially Insured Population in the United States. Completed NCT01260324
28 The Effects of Sevoflurane and Propofol on Light Flashed Evoked Pupillometry Completed NCT01219569 propofol;Sevoflurane
29 A Pilot Study to Determine the Effect on Intraocular Pressure, Optic Nerve Imaging and Other Markers of Venous Congestion of Volunteer Subjects in the Prone Position for a Period of Five Hours Completed NCT00875043
30 Evaluation of the Effectiveness and Safety of Transcorneal Electrical Stimulation to Improve Visual Function After Ocular Trauma Completed NCT02019927
31 A Prospective Case-crossover Study to Evaluate the Possible Association Between the Use of PDE5 Inhibitors and the Risk of Acute Nonarteritic Anterior Ischemic Optic Neuropathy (NAION) Completed NCT01131104 PDE5 Inhibitors
32 Visual Field Defects in Non-Arteritic Anterior Ischemic Optic Neuropathy: Effect of Vision Restoration Therapy (VRT) Completed NCT00140491
33 Pilot SINN; Assessment of Visual Field (vf)-Related Endpoints in Patients With Non-arteritic Ischemic Optic Neuropathy (N-AION) Completed NCT01614158
34 Neuroprotection and Neuroenhancement in a Model of Optic Nerve Neurodegeneration (Non Arteritic Ischemic Optic Neuropathy): Study of Morpho-functional Changes Related to Treatment With Citicoline Oral Solution Completed NCT03758118
35 A Pilot Study to Determine the Efficacy and Safety of Detecting Subtle Visual Changes During Visual Evoked Potential (VEP) Monitoring Using SightSaver ™ Flash Visual Evoked Potential Stimulator in Spine Prone Surgery Completed NCT02643615 Propofol;Desflurane
36 Case Crossover Study of PDE5 Inhibitor Exposure as a Potential "Trigger Factor" for Acute NAION Completed NCT00759174 No intervention
37 The Effect of Aortic Infrarenal Clamping and Unclamping On Intraocular Pressure During Abdominal Aortic Aneurysm (AAA) Repair Completed NCT00450294
38 Transcorneal Electrical Stimulation Therapy for Retinal Disease - A Randomized, Single-blind Pilot Study Completed NCT00804102
39 Retinal Neuro-vascular Coupling in Patients With Non-arteritic Anterior Ischemic Optic Neuropathy Recruiting NCT03401892
40 Diagnostic Accuracy of Optimized Diffusion-Weighted Imaging for Detecting Anterior Ischemic Optic Neuropathy Recruiting NCT04451265
41 New Non-invasive Modalities for Assessing Retinal Structure and Function:Preliminary Investigation Recruiting NCT03475173
42 Bone Marrow Derived Stem Cell Ophthalmology Treatment Study II Recruiting NCT03011541
43 Biomechanics of Optic Neuropathy Terminated NCT02982499

Search NIH Clinical Center for Nonarteritic Anterior Ischemic Optic Neuropathy

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Stem-cell-based therapeutic approaches for Nonarteritic Anterior Ischemic Optic Neuropathy:
Renexus (NT-501), CNTF-secreting cells for treatment of retinal diseases
Embryonic/Adult Cultured Cells Related to Nonarteritic Anterior Ischemic Optic Neuropathy:
Human retinal stem cells secreting CNTF PMIDs: 16805711 17508034 16505355 23049090 15684670 12581701 15223826 18830926

Cochrane evidence based reviews: optic neuropathy, ischemic

Genetic Tests for Nonarteritic Anterior Ischemic Optic Neuropathy

Genetic tests related to Nonarteritic Anterior Ischemic Optic Neuropathy:

# Genetic test Affiliating Genes
1 Nonarteritic Anterior Ischemic Optic Neuropathy, Susceptibility to 29 GP1BA
2 Nonarteritic Anterior Ischemic Optic Neuropathy 29

Anatomical Context for Nonarteritic Anterior Ischemic Optic Neuropathy

MalaCards organs/tissues related to Nonarteritic Anterior Ischemic Optic Neuropathy:

40
Eye, Bone Marrow, Retina, Bone, Heart, Endothelial, Neutrophil

Publications for Nonarteritic Anterior Ischemic Optic Neuropathy

Articles related to Nonarteritic Anterior Ischemic Optic Neuropathy:

(show top 50) (show all 1283)
# Title Authors PMID Year
1
Nonarteritic anterior ischemic optic neuropathy is associated with a specific platelet polymorphism located on the glycoprotein Ibalpha gene. 57 61 6
14711733 2004
2
Anterior ischemic optic neuropathy in eyes with optic disc drusen. 57 61
14718294 2004
3
Association between sleep apnea syndrome and nonarteritic anterior ischemic optic neuropathy. 57 61
12003609 2002
4
Familial anterior ischemic optic neuropathy and papillophlebitis. 57 61
2396658 1990
5
Ischemic optic neuropathy as the first manifestation of elevated cholesterol levels in young patients. 57
12750110 2003
6
Platelet membrane glycoprotein Ib: genetic polymorphism detected in the intact molecule and in proteolytic fragments. 6
1693792 1990
7
Cloning of the alpha chain of human platelet glycoprotein Ib: a transmembrane protein with homology to leucine-rich alpha 2-glycoprotein. 6
3303030 1987
8
Genetic polymorphism of platelet glycoprotein Ib. 6
6235867 1984
9
Three cases of non-inflammatory ischemic optic neuropathy occurring in the same family. 57
4479396 1974
10
Men's sexual health: evaluating the effectiveness of print- and PDA-based CME. 54 61
19453917 2009
11
Anterior ischemic optic neuropathy comorbid with Factor V Leiden and PAI-1 4G/5G mutation. 61 54
19507643 2009
12
Nonarteritic anterior ischemic optic neuropathy with PDE-5 inhibitors for erectile dysfunction. 54 61
18528398 2008
13
[Treatment of erectile dysfunction by phosphodiesterase-5 inhibitors and nonarteritic anterior ischemic optic neuropathy (NOIAN)]. 54 61
17969789 2007
14
Non-arteritic anterior ischemic optic neuropathy (NAION) and phosphodiesterase type-5 inhibitors. 54 61
17076943 2006
15
PDE5 inhibitors and permanent visual loss. 54 61
16193072 2005
16
Nonarteritic anterior ischemic optic neuropathy: associations with homozygosity for the C677T methylenetetrahydrofolate reductase mutation. 61 54
15007309 2004
17
Reversal of nonarteritic anterior ischemic optic neuropathy associated with coexisting primary antiphospholipid syndrome and Factor V Leiden mutation. 61 54
11336954 2001
18
Anterior ischemic optic neuropathy and activated protein C resistance. A case report and review of the literature. 61 54
9304527 1997
19
Giant cell arteritis with ocular involvement successfully treated with tocilizumab and very short-course glucocorticoids: A case report. 61
33712335 2021
20
Citicoline in Ophthalmological Neurodegenerative Disease: A Comprehensive Review. 61
33804675 2021
21
A Diagnostic Algorithm Based on a Simple Clinical Prediction Rule for the Diagnosis of Cranial Giant Cell Arteritis. 61
33802092 2021
22
Vascular Damage May Mimic Retinitis and Optic Neuritis in COVID-19. 61
33661715 2021
23
Microvascular and structural alterations in the optic nerve head of advanced primary open-angle glaucoma compared with atrophic non-arteritic anterior ischemic optic neuropathy. 61
33661365 2021
24
Contributing ocular comorbidity to end-of-life visual acuity in medically treated glaucoma patients, ocular hypertension and glaucoma suspect patients. 61
32494040 2021
25
Restricted Diffusion in the Optic Nerve Head After Shock-Induced Anterior Ischemic Optic Neuropathy. 61
32028450 2021
26
Ipsilateral Recurrence of Optic Disc Drusen-Associated Anterior Ischemic Optic Neuropathy in a 15-Year-Old Boy. 61
32235222 2021
27
Case Report: Combined Ischemic Optic Neuropathy and Central Retinal Artery Occlusion after Starting Hemodialysis. 61
33633019 2021
28
Patterns of Retinal Ganglion Cell Damage in Nonarteritic Anterior Ischemic Optic Neuropathy Assessed by Swept-Source Optical Coherence Tomography. 61
32868560 2021
29
Is Cataract Surgery a Risk for Developing Nonarteritic Anterior Ischemic Optic Neuropathy? 61
33587535 2021
30
Intravitreal Injection Of The Granulocyte-Colony Stimulating Factor For The Treatment Of Non-Arteritic Anterior Ischemic Optic Neuropathy: A Pilot Study. 61
33689586 2021
31
Follow-Up of Nonarteritic Anterior Ischemic Optic Neuropathy With Optical Coherence Tomography Angiography. 61
33635311 2021
32
Peripapillary Hyper-reflective Ovoid Mass-like Structure (PHOMS): An Optical Coherence Tomography Marker of Axoplasmic Stasis in the Optic Nerve Head. 61
33630781 2021
33
Antiphospholipid syndrome of bilateral nonarteritic anterior ischemic optic neuropathy patient with temporal aggravation. 61
33596624 2021
34
A Population-Based Study of Anterior Ischemic Optic Neuropathy Following Cataract Surgery. 61
32818451 2021
35
How curcumin affects hyperglycemia-induced optic nerve damage: A short review. 61
33581265 2021
36
The Benefits and Hazards of Intravitreal Mesenchymal Stem Cell (MSC) Based-Therapies in the Experimental Ischemic Optic Neuropathy. 61
33672743 2021
37
Transocular sonography in acute arterial occlusions of the eye in elderly patients: Diagnostic value of the spot sign. 61
33577572 2021
38
Biomarkers of lesion severity in a rodent model of nonarteritic anterior ischemic optic neuropathy (rNAION). 61
33764998 2021
39
Comments on: Vogt - Koyanagi - Harada disease associated with anterior ischemic optic neuropathy in a young woman presenting as acute angle-closure glaucoma. 61
33323630 2021
40
Nonarteritic Anterior Ischemic Optic Neuropathy following Herpes Zoster Ophthalmicus and Steroid-Related Intraocular Pressure Spike. 61
33613245 2021
41
Should All Patients With Nonarteritic Anterior Ischemic Optic Neuropathy Receive a Sleep Study? 61
33417413 2021
42
Anterior Ischemic Optic Neuropathy Secondary to Carotid Artery Dissection. 61
33417422 2021
43
Response to comments on: Vogt-Koyanagi-Harada disease associated with anterior ischemic optic neuropathy in a young woman presenting as acute angle-closure glaucoma. 61
33323631 2021
44
A Promising Strategy for Non-Arteritic Anterior Ischemic Optic Neuropathy: Intravitreal Mesenchymal Stem Cell Exosome. 61
32798377 2021
45
No Evidence of Varicella-Zoster Virus Infection in Temporal Artery Biopsies of Anterior Ischemic Optic Neuropathy Patients With and Without Giant Cell Arteritis. 61
32901261 2021
46
OCT angiography analysis in acute non-arteritic anterior ischemic optic neuropathy: The importance of segmentation. 61
33307804 2020
47
Ischemic optic neuropathy after Descemet-stripping automated endothelial keratoplasty. 61
32842079 2020
48
A Case of Non-Arteritic Anterior Ischemic Optic Neuropathy with COVID-19. 61
33425529 2020
49
Serum Inflammatory Biomarkers in Patients with Nonarteritic Anterior Ischemic Optic Neuropathy. 61
33307608 2020
50
Bilateral diabetic papillopathy developed after starting insulin treatment. Potential toxic effect of insulin? A case report. 61
33353425 2020

Variations for Nonarteritic Anterior Ischemic Optic Neuropathy

ClinVar genetic disease variations for Nonarteritic Anterior Ischemic Optic Neuropathy:

6
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 GP1BA GP1BA, 92-BP DUP, SER399-THR411 DUP, VARIABLE REPEATS Duplication risk factor 4152 GRCh37:
GRCh38:
2 GP1BA NM_000173.7(GP1BA):c.256C>T (p.Leu86Phe) SNV Uncertain significance 417940 rs13306411 GRCh37: 17:4836155-4836155
GRCh38: 17:4932860-4932860

Expression for Nonarteritic Anterior Ischemic Optic Neuropathy

Search GEO for disease gene expression data for Nonarteritic Anterior Ischemic Optic Neuropathy.

Pathways for Nonarteritic Anterior Ischemic Optic Neuropathy

Pathways related to Nonarteritic Anterior Ischemic Optic Neuropathy according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.94 VEGFA SERPINC1 PDE5A NOS3 GP1BA F5
2 12.58 VEGFA F2 EDN1 AGTR1 AGT
3
Show member pathways
12.56 NOS3 F2 EDN1 AGTR1 AGT
4
Show member pathways
12.25 NOS3 EDN1 AGTR1 AGT
5
Show member pathways
11.87 SERPINC1 GP1BA F5 F2
6
Show member pathways
11.36 NOS3 AGTR1 AGT ACE
7 11.34 VEGFA NOS3 EDN1
8 11.1 EDN1 AGTR1 AGT ACE
9 11.02 VEGFA NOS3 EDN1 AGTR1 AGT
10
Show member pathways
10.97 VEGFA EDN1 CRP
11 10.59 PDE5A NOS3

GO Terms for Nonarteritic Anterior Ischemic Optic Neuropathy

Cellular components related to Nonarteritic Anterior Ischemic Optic Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.65 VEGFA SERPINC1 F5 F2 EDN1 CRP
2 extracellular space GO:0005615 9.36 VEGFA SERPINC1 GP1BA F5 F2 EDN1

Biological processes related to Nonarteritic Anterior Ischemic Optic Neuropathy according to GeneCards Suite gene sharing:

(show all 31)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 10.03 VEGFA F2 EDN1 CNTF AGT
2 positive regulation of gene expression GO:0010628 10.02 VEGFA POU4F1 NOS3 CRP CNTF
3 blood coagulation GO:0007596 9.88 SERPINC1 GP1BA F5 F2
4 kidney development GO:0001822 9.83 VEGFA AGTR1 AGT ACE
5 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.81 VEGFA F2 AGT
6 positive regulation of endothelial cell migration GO:0010595 9.77 VEGFA EDN1 AGT
7 blood vessel remodeling GO:0001974 9.69 NOS3 AGT ACE
8 positive regulation of blood coagulation GO:0030194 9.65 F2 APOH
9 positive regulation of renal sodium excretion GO:0035815 9.65 EDN1 AGT
10 positive regulation of reactive oxygen species metabolic process GO:2000379 9.65 F2 AGTR1 AGT
11 negative regulation of blood coagulation GO:0030195 9.64 EDN1 APOH
12 artery smooth muscle contraction GO:0014824 9.63 EDN1 AGT
13 negative regulation of fibrinolysis GO:0051918 9.62 F2 APOH
14 regulation of blood pressure GO:0008217 9.62 NOS3 EDN1 AGT ACE
15 negative regulation of smooth muscle cell apoptotic process GO:0034392 9.61 EDN1 APOH
16 positive regulation of cholesterol esterification GO:0010873 9.61 AGTR1 AGT
17 regulation of blood vessel diameter GO:0097746 9.61 NOS3 AGTR1 ACE
18 negative regulation of platelet activation GO:0010544 9.6 NOS3 F2
19 positive regulation of NAD(P)H oxidase activity GO:0033864 9.58 AGTR1 AGT
20 vasoconstriction GO:0042310 9.58 EDN1 CRP AGT
21 regulation of systemic arterial blood pressure by endothelin GO:0003100 9.57 NOS3 EDN1
22 positive regulation of peptidyl-tyrosine autophosphorylation GO:1900086 9.56 VEGFA ACE
23 hemostasis GO:0007599 9.56 SERPINC1 GP1BA F5 F2
24 regulation of renal sodium excretion GO:0035813 9.55 AGTR1 AGT
25 renin-angiotensin regulation of aldosterone production GO:0002018 9.54 AGTR1 AGT
26 blood coagulation, intrinsic pathway GO:0007597 9.54 GP1BA F2 APOH
27 regulation of blood vessel diameter by renin-angiotensin GO:0002034 9.49 AGTR1 AGT
28 regulation of renal output by angiotensin GO:0002019 9.46 AGT ACE
29 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 9.33 AGTR1 AGT ACE
30 regulation of vasoconstriction GO:0019229 9.26 EDN1 AGTR1 AGT ACE
31 regulation of blood coagulation GO:0030193 8.92 SERPINC1 GP1BA F2 APOH

Molecular functions related to Nonarteritic Anterior Ischemic Optic Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heparin binding GO:0008201 9.56 VEGFA SERPINC1 F2 APOH
2 growth factor activity GO:0008083 9.46 VEGFA F2 CNTF AGT
3 NADP binding GO:0050661 9.13 NOS3 MTHFR G6PD
4 bradykinin receptor binding GO:0031711 8.62 AGTR1 ACE

Sources for Nonarteritic Anterior Ischemic Optic Neuropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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