MCID: NNB001
MIFTS: 36

Nonbacterial Thrombotic Endocarditis

Categories: Blood diseases, Cardiovascular diseases, Immune diseases, Infectious diseases

Aliases & Classifications for Nonbacterial Thrombotic Endocarditis

MalaCards integrated aliases for Nonbacterial Thrombotic Endocarditis:

Name: Nonbacterial Thrombotic Endocarditis 12 12 15
Libman-Sacks Endocarditis 12 15
Libmann-Sachs, Endocarditis in Systemic Lupus Erythematosus 12
Non-Bacterial Thrombotic Endocarditis 12
Marantic Endocarditis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0060068 DOID:0080740
ICD10 32 M32.11

Summaries for Nonbacterial Thrombotic Endocarditis

Disease Ontology : 12 An endocarditis that results from the deposition of small sterile vegetations on valve leaflets.

MalaCards based summary : Nonbacterial Thrombotic Endocarditis, also known as libman-sacks endocarditis, is related to tricuspid valve insufficiency and endocarditis. An important gene associated with Nonbacterial Thrombotic Endocarditis is CFHR2 (Complement Factor H Related 2), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Folate Metabolism. Affiliated tissues include heart, bone marrow and bone.

Wikipedia : 74 Nonbacterial thrombotic endocarditis (NBTE) is a form of endocarditis in which small sterile vegetations... more...

Related Diseases for Nonbacterial Thrombotic Endocarditis

Diseases related to Nonbacterial Thrombotic Endocarditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 517)
# Related Disease Score Top Affiliating Genes
1 tricuspid valve insufficiency 31.0 F3 F2 CRP
2 endocarditis 30.7 SERPINC1 PF4 IL6 F2 CRP APOH
3 catastrophic antiphospholipid syndrome 30.7 F3 APOH ADAMTS13
4 aortic valve insufficiency 30.6 F3 F2 CRP
5 heart valve disease 30.5 F2 CRP APOH
6 mitral valve disease 30.5 F3 F2 CRP
7 intracranial embolism 30.4 SERPINC1 PLG F3 F2 CRP
8 spinal cord infarction 30.4 SERPINC1 F2 APOH
9 sneddon syndrome 30.3 SERPINC1 F2 APOH
10 systemic autoimmune disease 30.3 IL6 CRP
11 pulmonary edema 30.3 SERPINC1 F2 CRP
12 budd-chiari syndrome 30.3 SERPINC1 F3 F2 APOH
13 thrombotic microangiopathy 30.3 F3 ADAMTS13
14 facial paralysis 30.3 PRTN3 PLG CRP
15 hepatic veno-occlusive disease 30.3 SERPINC1 PLG F3
16 subacute bacterial endocarditis 30.2 PRTN3 CRP
17 hemopericardium 30.2 PLG F3 F2 CRP
18 infective endocarditis 30.2 PF4 IL6 F2 CRP APOH
19 pulmonary embolism 30.2 SERPINC1 F3 F2 CRP APOH
20 heparin-induced thrombocytopenia 30.1 SERPINC1 PF4 F3
21 homocysteinemia 30.1 SERPINC1 F2 CRP APOH
22 acute kidney failure 29.9 PRTN3 F2 ADAMTS13
23 thrombophilia 29.9 SERPINC1 PF4 F3 F2 APOH
24 thrombophilia due to thrombin defect 29.9 SERPINC1 PF4 F3 F2 APOH
25 bilirubin metabolic disorder 29.9 F3 F2 CRP ADAMTS13
26 thrombophlebitis 29.9 SERPINC1 PLG F3 F2 CRP APOH
27 hemolytic anemia 29.9 F3 F2 APOH ADAMTS13
28 thrombotic thrombocytopenic purpura 29.9 SERPINC1 F3 APOH ADAMTS13
29 antiphospholipid syndrome 29.8 SERPINC1 PF4 F3 F2 CRP APOH
30 cerebrovascular disease 29.8 IL6 F2 CRP APOH ADAMTS13
31 intracranial thrombosis 29.8 SERPINC1 PLG F3 F2 APOH
32 central retinal artery occlusion 29.7 SERPINC1 PRTN3 PLG F2 CRP
33 cellulitis 29.7 IL6 F3 F2 CRP
34 adult respiratory distress syndrome 29.7 PLG IL6 F2
35 branch retinal artery occlusion 29.7 SERPINC1 PRTN3 PLG F2 CRP APOH
36 polyarteritis nodosa 29.7 PRTN3 IL6 CRP APOH
37 coronary stenosis 29.7 IL6 CRP ADAMTS13
38 disseminated intravascular coagulation 29.6 SERPINC1 PLG IL6 F3 F2 CRP
39 autoimmune disease 29.5 PRTN3 IL6 F3 CRP APOH
40 vasculitis 29.5 PRTN3 IL6 CRP APOH
41 systemic lupus erythematosus 29.5 PRTN3 IL6 F3 F2 CRP CFHR2
42 disease by infectious agent 29.5 PRTN3 IL6 CRP CFHR2
43 respiratory failure 29.5 PF4 IL6 F3 F2 CRP
44 patent foramen ovale 29.5 SERPINC1 PLG F3 F2 CRP APOH
45 pericardial effusion 29.5 PRTN3 IL6 F3 F2 CRP
46 lung disease 29.5 PRTN3 IL6 F3 CRP
47 retinal artery occlusion 29.5 SERPINC1 PLG IL6 F2 CRP APOH
48 mitral valve stenosis 29.3 SERPINC1 PLG PF4 F3 F2 CRP
49 splenic infarction 29.3 SERPINC1 PRTN3 F3 F2 CRP APOH
50 connective tissue disease 29.2 IL6 CRP CFHR2 APOH ADAMTS13

Graphical network of the top 20 diseases related to Nonbacterial Thrombotic Endocarditis:



Diseases related to Nonbacterial Thrombotic Endocarditis

Symptoms & Phenotypes for Nonbacterial Thrombotic Endocarditis

Drugs & Therapeutics for Nonbacterial Thrombotic Endocarditis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Libman-Sacks Endocarditis as a Cause of Neuropsychiatric Systemic Lupus Erythematosus Completed NCT00858884

Search NIH Clinical Center for Nonbacterial Thrombotic Endocarditis

Genetic Tests for Nonbacterial Thrombotic Endocarditis

Anatomical Context for Nonbacterial Thrombotic Endocarditis

MalaCards organs/tissues related to Nonbacterial Thrombotic Endocarditis:

40
Heart, Bone Marrow, Bone, Brain, Skin, Eye, Liver

Publications for Nonbacterial Thrombotic Endocarditis

Articles related to Nonbacterial Thrombotic Endocarditis:

(show top 50) (show all 501)
# Title Authors PMID Year
1
A hybrid endocardial-epicardial biventricular implantable cardioverter-defibrillator to circumvent the tricuspid valve. 61
33085111 2021
2
[How to diagnose Libman-Sacks endocarditis with echocardiography?] 61
33390582 2021
3
Distinguishing aortic valve thrombus from Libman-Sacks endocarditis in antiphospholipid syndrome: imaging and management. 61
32648500 2021
4
Surgical management of Libman-Sacks mitral valve endocarditis. 61
33529822 2021
5
Libman-Sacks endocarditis and associated cerebrovascular disease: The role of medical therapy. 61
33592060 2021
6
Mitral valve 'kissing lesion' in Libman-Sacks endocarditis. 61
33401301 2021
7
Mitral Valve Repair for Isolated Libman-Sacks Endocarditis in a Patient with Primary Antiphospholipid Syndrome. 61
33518657 2021
8
Treatment with a Direct Oral Anticoagulant for Nonbacterial Thrombotic Endocarditis. 61
33456040 2021
9
Corrigendum to: Antemortem diagnosis of nonbacterial thrombotic endocarditis in a patient with previously resected pancreatic adenocarcinoma: a case report. 61
33442631 2020
10
Nonbacterial Thrombotic Endocarditis-A Rare Case of Acute Libman-Sacks Endocarditis Complicated by Multiple Cerebral Infarcts: Case Report and Literature Review. 61
33376843 2020
11
[The pathology of the thrombi obtained by endovascular thrombectomy were useful for diagnosis of two cases of cardiogenic cerebral embolism due to infective endocarditis and nonbacterial thrombotic endocarditis]. 61
33229830 2020
12
Severe Nonbacterial Thrombotic Endocarditis Resulting in Aortic Valve Insufficiency and Multiple Small Strokes in a Patient With Metastatic Pancreatic Cancer: Lessons for Optimal Management. 61
32900633 2020
13
[Libman-Sacks endocarditis under apixaban in a patient with a high-risk profile venous antiphospholipid syndrome]. 61
33153775 2020
14
Development of Nonbacterial Thrombotic Endocarditis While on Systemic Anticoagulation in Pancreatic Cancer: A Case Report. 61
33209525 2020
15
Natural history of nonbacterial thrombotic endocarditis treated with warfarin. 61
33040698 2020
16
Antemortem diagnosis of nonbacterial thrombotic endocarditis in a patient with previously resected pancreatic adenocarcinoma: a case report. 61
33216825 2020
17
Nonbacterial Thrombotic Endocarditis Related to Adenocarcinoma of the Uterine Cervix. 61
33505293 2020
18
Recurrent nonbacterial thrombotic endocarditis and stroke on anticoagulation. 61
33235685 2020
19
Long-term follow-up of antiphospholipid syndrome: real-life experience from a single center. 61
32536318 2020
20
Do all antiphospholipid antibodies confer the same risk for major organ involvement in systemic lupus erythematosus patients? 61
32828148 2020
21
Clinical characteristics and long-term outcomes of Libman-Sacks endocarditis in patients with systemic lupus erythematosus. 61
32536317 2020
22
Near complete resolution of nonbacterial thrombotic endocarditis in a patient with antiphospholipid antibody syndrome. 61
32749246 2020
23
A Contemporary 20-Year Cleveland Clinic Experience of Nonbacterial Thrombotic Endocarditis: Etiology, Echocardiographic Imaging, Management, and Outcomes. 61
32827467 2020
24
Coronary embolism in a young patient with nonbacterial thrombotic endocarditis related to antiphospholipid syndrome. 61
32732516 2020
25
Chemotherapy-associated nonbacterial thrombotic endocarditis: A radiological mimicker of cardiac amyloidosis requiring histopathologic examination for definitive diagnosis. 61
32142924 2020
26
Antiphospholipid syndrome and the relationship between laboratory assay positivity and prevalence of non-bacterial thrombotic endocarditis: A retrospective cohort study. 61
32180317 2020
27
Outcome of Stroke Patients with Cancer and Nonbacterial Thrombotic Endocarditis. 61
32635688 2020
28
Nonbacterial thrombotic endocarditis of a bioprosthetic valve: Questions to ponder before replacement of the valve. 61
32275092 2020
29
Mitral Valve Prosthesis Dehiscence with Severe Regurgitation and Pseudoaneurysm in a Young Woman with Recurrent Nonbacterial Thrombotic Endocarditis. 61
32337392 2020
30
Nonbacterial thrombotic endocarditis in multiple heart valves. 61
31710414 2020
31
A Transesophageal Echocardiogram Finding: From Infection to Malignancy. 61
32190449 2020
32
Hypertrophic obstructive cardiomyopathy and mitral regurgitation in Libman-Sacks endocarditis. 61
30519962 2020
33
Diagnostic performance of aPS/PT antibodies in neuropsychiatric lupus and cardiovascular complications of systemic lupus erythematosus. 61
31782311 2020
34
Cardiovascular Disease in Antiphospholipid Syndrome. 61
31530257 2020
35
Nonbacterial Thrombotic Endocarditis. 61
32226584 2020
36
Nonbacterial thrombotic endocarditis as an initial presentation of advanced cholangiocarcinoma in a young patient: A case report. 61
32850128 2020
37
Nonbacterial Thrombotic Endocarditis and Widespread Skin Necrosis in Newly Diagnosed Lung Adenocarcinoma. 61
32308583 2020
38
Lung Adenocarcinoma Presenting as Multiple Thromboembolic Events: A Case Report and Review of the Literature. 61
33138640 2020
39
Severe mitral valve regurgitation secondary to Libman-Sacks endocarditis. 61
33224587 2020
40
Treatment of Libman-Sacks endocarditis by combination of warfarin and immunosuppressive therapy. 61
31802766 2019
41
Acute papillary muscle infarction and rupture in the puerperium complicating Libman-Sacks endocarditis in a patient with systemic lupus erythematosus and antiphospholipid syndrome: a case report. 61
32099964 2019
42
Pediatric systemic lupus erythematosus patients in South Africa have high prevalence and severity of cardiac and vascular manifestations. 61
31771606 2019
43
Nonbacterial thrombotic endocarditis as the initial presentation of prostate cancer- a case report. 61
31740891 2019
44
Cardiac and neurological involvement in Antiphospholipid syndrome: a case of a 47-year-old woman with nonbacterial thrombotic endocarditis and cognitive impairment. 61
29936322 2019
45
Libman-Sacks endocarditis in a Bangladeshi patient suffering from rhupus. 61
31180802 2019
46
Unicuspid aortic valve concomitant with aortic insufficiency presenting with infectious endocarditis: a case report. 61
31537200 2019
47
Nonbacterial Thrombotic Endocarditis Due to Primary Gallbladder Malignancy with Recurrent Stroke Despite Anticoagulation: Case Report and Literature Review. 61
31313109 2019
48
Immunosuppressive therapy to reduce mitral regurgitation in Libman-Sacks endocarditis: a case report. 61
31377769 2019
49
Neurologic Complications of Infective Endocarditis: A Joint Model for a Septic Thromboembolism and Inflammatory Small Vessel Disease. 61
31149963 2019
50
Stroke in malignancy: complexities of diagnosis and management: a case report. 61
31426851 2019

Variations for Nonbacterial Thrombotic Endocarditis

Expression for Nonbacterial Thrombotic Endocarditis

Search GEO for disease gene expression data for Nonbacterial Thrombotic Endocarditis.

Pathways for Nonbacterial Thrombotic Endocarditis

GO Terms for Nonbacterial Thrombotic Endocarditis

Cellular components related to Nonbacterial Thrombotic Endocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.85 SERPINC1 PRTN3 PLG PF4 IL6 F3
2 endoplasmic reticulum lumen GO:0005788 9.56 SERPINC1 IL6 F2 ADAMTS13
3 blood microparticle GO:0072562 9.5 SERPINC1 PLG F2
4 collagen-containing extracellular matrix GO:0062023 9.5 SERPINC1 PRTN3 PLG PF4 F3 F2
5 extracellular region GO:0005576 9.4 SERPINC1 PRTN3 PLG PF4 IL6 F3

Biological processes related to Nonbacterial Thrombotic Endocarditis according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.87 PF4 IL6 F3 CRP
2 proteolysis GO:0006508 9.83 PRTN3 PLG F2 ADAMTS13 ACR
3 cytokine-mediated signaling pathway GO:0019221 9.76 PRTN3 PF4 IL6 F3
4 cellular response to lipopolysaccharide GO:0071222 9.73 PF4 IL6 ADAMTS13
5 cellular protein metabolic process GO:0044267 9.71 SERPINC1 PLG IL6 F2
6 platelet degranulation GO:0002576 9.7 PLG PF4 APOH
7 platelet activation GO:0030168 9.62 PF4 IL6 F2 ADAMTS13
8 fibrinolysis GO:0042730 9.55 PLG F2
9 blood coagulation, intrinsic pathway GO:0007597 9.54 F2 APOH
10 acute-phase response GO:0006953 9.54 IL6 F2 CRP
11 positive regulation of blood coagulation GO:0030194 9.51 F2 APOH
12 cytolysis by host of symbiont cells GO:0051838 9.49 F2 CFHR2
13 negative regulation of lipid storage GO:0010888 9.48 IL6 CRP
14 regulation of blood coagulation GO:0030193 9.43 SERPINC1 F2 APOH
15 blood coagulation GO:0007596 9.43 SERPINC1 PRTN3 PLG F3 F2 ADAMTS13
16 negative regulation of fibrinolysis GO:0051918 9.33 PLG F2 APOH
17 hemostasis GO:0007599 9.02 SERPINC1 PLG F3 F2 ADAMTS13

Molecular functions related to Nonbacterial Thrombotic Endocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidase activity GO:0008233 9.65 PRTN3 PLG F2 ADAMTS13 ACR
2 protease binding GO:0002020 9.5 SERPINC1 F3 ACR
3 heparin binding GO:0008201 9.46 SERPINC1 PF4 F2 APOH
4 serine-type peptidase activity GO:0008236 9.26 PRTN3 PLG F2 ACR
5 serine-type endopeptidase activity GO:0004252 9.02 PRTN3 PLG F3 F2 ACR

Sources for Nonbacterial Thrombotic Endocarditis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....