MCID: NNB001
MIFTS: 37

Nonbacterial Thrombotic Endocarditis

Categories: Blood diseases, Cardiovascular diseases, Infectious diseases
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Aliases & Classifications for Nonbacterial Thrombotic Endocarditis

MalaCards integrated aliases for Nonbacterial Thrombotic Endocarditis:

Name: Nonbacterial Thrombotic Endocarditis 11 14 75
Non-Bacterial Thrombotic Endocarditis 11 71
Non-Infective Endocarditis 71
Marantic Endocarditis 11

Classifications:



External Ids:

Disease Ontology 11 DOID:0060068
UMLS 71 C0221390 C3202971

Summaries for Nonbacterial Thrombotic Endocarditis

Disease Ontology: 11 An endocarditis that results from the deposition of small sterile vegetations on valve leaflets.

MalaCards based summary: Nonbacterial Thrombotic Endocarditis, also known as non-bacterial thrombotic endocarditis, is related to endocarditis and mitral valve insufficiency. An important gene associated with Nonbacterial Thrombotic Endocarditis is F3 (Coagulation Factor III, Tissue Factor), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. Affiliated tissues include bone marrow, lung and heart, and related phenotypes are homeostasis/metabolism and cardiovascular system

Wikipedia: 75 Nonbacterial thrombotic endocarditis (NBTE) is a form of endocarditis in which small sterile vegetations... more...

Related Diseases for Nonbacterial Thrombotic Endocarditis

Diseases related to Nonbacterial Thrombotic Endocarditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 501)
# Related Disease Score Top Affiliating Genes
1 endocarditis 31.0 SERPINC1 PLAT F2 CRP APOH
2 mitral valve insufficiency 30.9 F3 F2 CRP
3 infective endocarditis 30.7 VWF PLG F3 F2 CRP
4 hemiplegia 30.5 PLG PLAT CRP
5 aphasia 30.5 PLG PLAT CRP
6 hemophilia 30.5 VWF F2
7 pulmonary edema 30.4 SERPINC1 F2 CRP
8 heparin-induced thrombocytopenia 30.4 F3 F2
9 lateral medullary syndrome 30.3 PLG CRP
10 aortic valve insufficiency 30.3 VWF F3 F2 CRP
11 acute vascular insufficiency of intestine 30.3 SERPINC1 CRP
12 polycythemia 30.3 F3 F2 CRP
13 cellulitis 30.3 F3 F2 CRP
14 lymphangitis 30.3 CRP CEACAM5
15 urinary tract infection 30.3 F3 F2 CRP
16 inguinal hernia 30.3 F3 F2 CRP
17 central nervous system origin vertigo 30.2 SERPINC1 PLG F2
18 cerebral artery occlusion 30.2 PLG PLAT
19 ovarian cyst 30.1 CRP CEACAM5
20 cranial nerve palsy 30.1 SERPINC1 F2 CRP
21 brain stem infarction 30.0 PLG PLAT CRP
22 facial paralysis 30.0 PLG PLAT CRP
23 covid-19 29.9 PLG F3 F2 CRP
24 aortic dissection 29.9 PLG F3 F2 CRP
25 libman-sacks endocarditis 29.9 F2 CRP APOH
26 sneddon syndrome 29.9 SERPINC1 F2 APOH
27 vasculitis 29.8 VWF CRP APOH
28 vitamin k deficiency bleeding 29.8 SERPINC1 F7 F3 F2
29 hepatic veno-occlusive disease 29.8 SERPINC1 PLG PLAT F3
30 collagen disease 29.8 VWF CRP APOH
31 factor vii deficiency 29.7 SERPINC1 F7 F3 F2
32 heart valve disease 29.7 VWF F3 F2 CRP APOH
33 intracranial embolism 29.7 VWF SERPINC1 PLG PLAT F3 F2
34 qualitative platelet defect 29.7 VWF F7 F3 F2
35 severe pre-eclampsia 29.7 SERPINC1 F3 F2 APOH
36 antiphospholipid syndrome 29.7 VWF SERPINC1 PLAT F3 F2 CRP
37 limb ischemia 29.6 VWF SERPINC1 PLG F3 CRP
38 thrombotic thrombocytopenic purpura 29.6 VWF SERPINC1 F3 APOH
39 respiratory failure 29.6 VWF SERPINC1 PLG F3 F2 CRP
40 thrombophilia due to thrombin defect 29.6 VWF SERPINC1 PLAT F3 F2 APOH
41 disseminated intravascular coagulation 29.6 VWF SERPINC1 PLG PLAT F7 F3
42 cardiac tamponade 29.6 PLG PLAT F3 F2 CRP
43 hemopericardium 29.5 PLG PLAT F3 F2 CRP
44 splenic infarction 29.4 SERPINC1 F3 F2 CRP APOH
45 raynaud disease 29.4 VWF PLAT CRP APOH
46 cerebrovascular disease 29.4 PLG PLAT F2 CRP APOH
47 pulmonary embolism 29.3 VWF SERPINC1 PLAT F3 F2 CRP
48 bilirubin metabolic disorder 29.3 VWF SERPINC1 F3 F2 CRP CEACAM5
49 purpura 29.1 VWF SERPINC1 F3 F2 CRP APOH
50 acute myocardial infarction 29.1 VWF SERPINC1 PLAT F7 F3 F2

Graphical network of the top 20 diseases related to Nonbacterial Thrombotic Endocarditis:



Diseases related to Nonbacterial Thrombotic Endocarditis

Symptoms & Phenotypes for Nonbacterial Thrombotic Endocarditis

MGI Mouse Phenotypes related to Nonbacterial Thrombotic Endocarditis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.96 APOH CEACAM5 CRP F2 F3 F7
2 cardiovascular system MP:0005385 9.81 CEACAM5 CRP F2 F3 F7 PLAT
3 immune system MP:0005387 9.56 CEACAM5 CRP F2 F3 PLAT PLG
4 mortality/aging MP:0010768 9.28 APOH CEACAM5 F2 F3 F7 PLAT

Drugs & Therapeutics for Nonbacterial Thrombotic Endocarditis

Search Clinical Trials, NIH Clinical Center for Nonbacterial Thrombotic Endocarditis

Genetic Tests for Nonbacterial Thrombotic Endocarditis

Anatomical Context for Nonbacterial Thrombotic Endocarditis

Organs/tissues related to Nonbacterial Thrombotic Endocarditis:

MalaCards : Bone Marrow, Lung, Heart, Bone, Pancreas, Colon, Liver

Publications for Nonbacterial Thrombotic Endocarditis

Articles related to Nonbacterial Thrombotic Endocarditis:

(show top 50) (show all 560)
# Title Authors PMID Year
1
A Rare Case of Tricuspid Valve Libman-Sacks Endocarditis in a Pregnant Woman with Primary Antiphospholipid Syndrome. 62
36233742 2022
2
Cardiovascular Manifestations in Systemic Lupus Erythematosus-Focus on Valvular Heart Disease and Non-Bacterial Thrombotic Endocarditis. 62
35729855 2022
3
Quadrivalvular nonbacterial thrombotic endocarditis in a patient with clear cell cervical cancer. 62
36267820 2022
4
Non-surgical extirpation of a non-infectious expanding tricuspid valve mass by percutaneous aspiration thrombectomy. 62
36255148 2022
5
A New Insight Into Nonbacterial Thrombotic Endocarditis: A Systematic Review of Cases. 62
36052565 2022
6
Percutaneous Debulking of Mitral Valve Nonbacterial Thrombotic Endocarditis. 62
36265944 2022
7
Heartbeat: knowledge gaps for non-bacterial thrombotic endocarditis. 62
36162848 2022
8
A rare case of metastatic pancreatic adenocarcinoma presenting as a pulmonary embolism from nonbacterial thrombotic endocarditis. 62
35784781 2022
9
The marantic kiss: potential novel pathognomonic echocardiographic sign of non-bacterial thrombotic endocarditis. 62
36151865 2022
10
Non-bacterial thrombotic endocarditis: manifestations and diagnosis in the age of echocardiography. 62
35609961 2022
11
[Nonbacterial Thrombotic Endocarditis Caused by Antiphospholipid Antibody Syndrome:Report of a Case]. 62
36156522 2022
12
Nonbacterial Thrombotic Endocarditis Progressed Aortic Stenosis of a Bicuspid Aortic Valve in a Patient With Advanced Cancer. 62
35491181 2022
13
Unusual Presentation of Isolated Nonbacterial Thrombotic Tricuspid Valve Endocarditis in Systemic Lupus Erythematosus With Secondary Antiphospholipid Syndrome: A Case Report. 62
35949940 2022
14
Pancreatic cancer with multiple liver metastasis complicating multi-organ infarcts from marantic endocarditis and Trousseau's syndrome. 62
36220250 2022
15
Severe Aortic Regurgitation by Nonbacterial Thrombotic Endocarditis Treated with Anticoagulation Therapy. 62
35832824 2022
16
Nonbacterial Thrombotic Endocarditis With Leptomeningeal Carcinomatosis: A Rare Presentation of Advanced Rectal Adenocarcinoma. 62
35812530 2022
17
COVID19 INFECTION AND LIBMAN -SACKS ENDOCARDITIS IN PAST VALVE REPAIRED PATIENT. 62
36027029 2022
18
Heparin treatment ameliorates aortic regurgitation due to malignancy-associated non-bacterial thrombotic endocarditis. 62
35179570 2022
19
Extensive Vegetation on the Mitral Valve Due to Non-Bacterial Thrombotic Endocarditis. 62
35774076 2022
20
Cancer-associated non-bacterial thrombotic endocarditis. 62
36210554 2022
21
Left ventricular free-wall rupture: An unusual presentation of non-bacterial thrombotic endocarditis. 62
35575314 2022
22
Non-bacterial Thrombotic Endocarditis as a Rare Manifestation of Early Stage Gastric Cancer. 62
35747008 2022
23
Contemporary demographics, diagnostics and outcomes in non-bacterial thrombotic endocarditis. 62
35534050 2022
24
Recurrent Cardioembolic Strokes Due to Marantic Endocarditis As the Initial Presentation of Colorectal Adenocarcinoma. 62
35592190 2022
25
Nonbacterial Thrombotic Endocarditis with Multiple Systemic Emboli in a Patient with Primary Lung Cancer. 62
36249435 2022
26
A Patient's Six-Month Journey From Low Sodium to Blue Toes to Stroke: Non-infective Thrombotic Endocarditis Due to Non-small Cell Lung Cancer. 62
35475040 2022
27
Recurrent nonbacterial thrombotic endocarditis the day after mitral valve replacement. 62
35261691 2022
28
Reversibility of valve regurgitation due to cancer-related non-bacterial thrombotic endocarditis after switching direct oral anticoagulation for heparin. 62
35296493 2022
29
Causes of ischemic stroke in young adults versus non-young adults: A multicenter hospital-based observational study. 62
35830430 2022
30
A Review of Cardiac Manifestations in Patients With Systemic Lupus Erythematosus and Antiphospholipid Syndrome With Focus on Endocarditis. 62
35242470 2022
31
Atypical Presentation of Marantic Endocarditis. 62
35891698 2022
32
Splinters in the fingernails, heart and brain: thromboembolic complications of non-bacterial thrombotic endocarditis despite treatment with a direct-acting oral anticoagulant. 62
35083053 2022
33
Multimodality Imaging for the Evaluation of an Undifferentiated Pleomorphic Sarcoma Presenting as Cardioembolic Stroke. 62
35342650 2022
34
Marantic Endocarditis in a Long-Standing Untreated Rheumatoid Arthritis Patient. 62
32558680 2021
35
Case report: aortic bioprosthesis marantic endocarditis. 62
33047667 2021
36
[Non-bacterial thrombotic endocarditis]. 62
35129890 2021
37
Multi-territory stroke preceded by pulmonary embolism with asymptomatic coronavirus disease 2019: a case report. 62
34993406 2021
38
Non-bacterial thrombotic endocarditis in pancreatic cancer and other high-risk malignancies: the case for prophylactic treatment. 62
34858625 2021
39
Case report: marantic endocarditis in renal cell carcinoma: nephrectomy a treatment. 62
34859186 2021
40
Mesothelioma with Nonbacterial Thrombotic Endocarditis: A Case Report. 62
35199758 2021
41
Acute ischaemia of the lower limb due to non-bacterial thrombotic endocarditis with recent venous thrombo-embolic disease as the initial manifestation of lung adenocarcinoma: a case report. 62
34859183 2021
42
Nonbacterial Thrombotic Endocarditis Associated with Acute Promyelocytic Leukemia: An Autopsy Case Report. 62
34833482 2021
43
Cardiac involvement in Beh├žet disease presenting as non-bacterial thrombotic endocarditis: A case report. 62
35059048 2021
44
Recurrent Strokes as the First Presentation of Occult Pancreatic Cancer; Trousseau Syndrome: A Case Report. 62
35082634 2021
45
Malignancy-Associated Non-Bacterial Thrombotic Endocarditis Causing Aortic Regurgitation and Leading to Aortic Valve Replacement. 62
34261592 2021
46
Non-bacterial thrombotic endocarditis with cryptogenic stroke. 62
34552744 2021
47
Initial Presentation, Management, and Outcomes from a Contemporary 20-Year Cleveland Clinic Experience of Nonbacterial Thrombotic Endocarditis. 62
34340755 2021
48
Coronary embolism in a young patient with nonbacterial thrombotic endocarditis related to antiphospholipid syndrome. 62
32732516 2021
49
Antithrombotic Therapy for Stroke Patients with Cardiovascular Disease. 62
33851394 2021
50
Nonbacterial thrombotic endocarditis in a patient with gastric cancer and SARS-CoV-2 infection. 62
33835416 2021

Variations for Nonbacterial Thrombotic Endocarditis

Expression for Nonbacterial Thrombotic Endocarditis

Search GEO for disease gene expression data for Nonbacterial Thrombotic Endocarditis.

Pathways for Nonbacterial Thrombotic Endocarditis

Pathways related to Nonbacterial Thrombotic Endocarditis according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.67 VWF SERPINC1 PLG PLAT F7 F3
2
Show member pathways
12.38 SERPINC1 F7 F3 F2
3
Show member pathways
12.04 SERPINC1 PLG F2
4
Show member pathways
11.63 VWF SERPINC1 PLG PLAT F7 F3
5 11.52 CEACAM5 F3 PLG
6 11.12 PLG CEACAM5
7 11.08 F3 F2
8
Show member pathways
11 F7 F2
9 10.95 PLG F2
10 10.9 PLG PLAT
11 10.77 PLG PLAT
12 10.44 PLG PLAT
13 10 PLG F2

GO Terms for Nonbacterial Thrombotic Endocarditis

Cellular components related to Nonbacterial Thrombotic Endocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 10.11 APOH CRP F2 F3 F7 PLAT
2 cell surface GO:0009986 10.02 PLG PLAT F3 CEACAM5 APOH
3 extracellular region GO:0005576 9.93 APOH CEACAM5 CRP F2 F3 F7
4 serine-type endopeptidase complex GO:1905370 9.67 F7 F2
5 serine-type peptidase complex GO:1905286 9.56 F7 F3
6 collagen-containing extracellular matrix GO:0062023 9.5 VWF SERPINC1 PLG PLAT F7 F3

Biological processes related to Nonbacterial Thrombotic Endocarditis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 fibrinolysis GO:0042730 9.85 PLG PLAT F2
2 positive regulation of positive chemotaxis GO:0050927 9.8 F7 F3
3 positive regulation of blood coagulation GO:0030194 9.8 F7 F2 APOH
4 blood coagulation GO:0007596 9.8 VWF SERPINC1 PLG PLAT F7 F3
5 plasminogen activation GO:0031639 9.78 PLAT APOH
6 negative regulation of fibrinolysis GO:0051918 9.76 PLG PLAT F2 APOH
7 trans-synaptic signaling by BDNF, modulating synaptic transmission GO:0099183 9.73 PLG PLAT
8 positive regulation of platelet-derived growth factor receptor signaling pathway GO:0010641 9.71 F7 F3
9 regulation of blood coagulation GO:0030193 9.56 APOH F2 SERPINC1
10 regulation of body fluid levels GO:0050878 9.46 F7 F2
11 hemostasis GO:0007599 9.17 VWF SERPINC1 PLG F7 F3 F2

Molecular functions related to Nonbacterial Thrombotic Endocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 9.73 VWF SERPINC1 F3
2 peptidase activity GO:0008233 9.46 PLG PLAT F7 F2
3 serine-type peptidase activity GO:0008236 9.43 PLG PLAT F7 F2
4 serine-type endopeptidase activity GO:0004252 9.32 PLG PLAT F7 F3 F2

Sources for Nonbacterial Thrombotic Endocarditis

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 24-Oct-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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