Aliases & Classifications for Nondisjunction

MalaCards integrated aliases for Nondisjunction:

Name: Nondisjunction 56 29 71
Mosaicism, Chromosomal 56
Mixoploidy, Familial 56

Characteristics:

OMIM:

56
Miscellaneous:
decreased fertility
increased tendency to chromosomal nondisjunction
increased aneuploidy in offspring
inheritance pattern is unclear

Inheritance:
autosomal recessive
autosomal dominant



Classifications:



External Ids:

OMIM 56 158250
MedGen 41 C1834741
SNOMED-CT via HPO 68 17276009 258211005 263681008
UMLS 71 C1834741

Summaries for Nondisjunction

OMIM : 56 Chromosomal mosaicism as described here refers to a tendency to chromosomal nondisjunction. See also premature chromatid separation (PCS; 176430), which may also predispose to chromosomal nondisjunction. (158250)

MalaCards based summary : Nondisjunction, also known as mosaicism, chromosomal, is related to down syndrome and gastrointestinal stromal tumor. An important gene associated with Nondisjunction is GART (Phosphoribosylglycinamide Formyltransferase, Phosphoribosylglycinamide Synthetase, Phosphoribosylaminoimidazole Synthetase), and among its related pathways/superpathways are Folate Metabolism and One carbon pool by folate. Affiliated tissues include testes, heart and thyroid, and related phenotypes are decreased fertility and abnormality of chromosome segregation

Wikipedia : 74 Nondisjunction is the failure of homologous chromosomes or sister chromatids to separate properly during... more...

Related Diseases for Nondisjunction

Diseases related to Nondisjunction via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 127)
# Related Disease Score Top Affiliating Genes
1 down syndrome 30.7 MTRR MTHFR GRIK1 GART
2 gastrointestinal stromal tumor 29.1 MTRR MTHFR KIT
3 chromosome 15, trisomy mosaicism 11.4
4 trisomy 17 mosaicism 11.2
5 premature chromatid separation trait 11.2
6 triple x syndrome 11.2
7 49, xxxxx 11.2
8 49, xxxyy syndrome 11.2
9 chromosomal triplication 10.9
10 patau syndrome 10.8
11 mosaic trisomy 8 10.7
12 47,xyy 10.5
13 47, xxy 10.3
14 angelman syndrome 10.3
15 orofaciodigital syndrome viii 10.2
16 total autosomal monosomy 10.2
17 autosomal monosomy 10.2
18 prader-willi syndrome 10.2
19 infertility 10.2
20 tetrasomy 18p 10.1
21 lymphocytic leukemia 10.1
22 gonadal dysgenesis 10.1
23 tetraploidy 10.1
24 triploidy 10.1
25 trisomy 22 10.1
26 maternal uniparental disomy 10.1
27 paternal uniparental disomy 10.1
28 chromosome 10, uniparental disomy 10.1
29 chromosome 16 trisomy 10.1
30 chromosome 20 trisomy 10.1
31 mosaic trisomy 13 10.1
32 mosaic trisomy 14 10.1
33 mosaic trisomy 22 10.1
34 mosaic trisomy 7 10.1
35 mosaic trisomy 9 10.1
36 trisomy 2 mosaicism 10.1
37 monosomy 21 10.1
38 mosaic trisomy 17 10.1
39 mosaic trisomy 1 10.1
40 mosaic trisomy 12 10.1
41 mosaic trisomy 15 10.1
42 monosomy 22 10.1
43 mosaic trisomy 4 10.1
44 mosaic trisomy 5 10.1
45 mosaic trisomy 3 10.1
46 dysgerminoma 10.0 LOC108348017 KIT
47 alzheimer disease 10.0
48 cat eye syndrome 10.0
49 polykaryocytosis inducer 10.0
50 silver-russell syndrome 10.0

Graphical network of the top 20 diseases related to Nondisjunction:



Diseases related to Nondisjunction

Symptoms & Phenotypes for Nondisjunction

Human phenotypes related to Nondisjunction:

31
# Description HPO Frequency HPO Source Accession
1 decreased fertility 31 HP:0000144
2 abnormality of chromosome segregation 31 HP:0002916

Symptoms via clinical synopsis from OMIM:

56
Laboratory Abnormalities:
chromosomal mosaicism in cultured cells

Clinical features from OMIM:

158250

Drugs & Therapeutics for Nondisjunction

Search Clinical Trials , NIH Clinical Center for Nondisjunction

Genetic Tests for Nondisjunction

Genetic tests related to Nondisjunction:

# Genetic test Affiliating Genes
1 Nondisjunction 29

Anatomical Context for Nondisjunction

MalaCards organs/tissues related to Nondisjunction:

40
Testes, Heart, Thyroid, Bone, Myeloid, Lung, Bone Marrow

Publications for Nondisjunction

Articles related to Nondisjunction:

(show top 50) (show all 1361)
# Title Authors PMID Year
1
Trisomy recurrence: a reconsideration based on North American data. 61 56
15248154 2004
2
Frequency of consanguineous marriages among parents and grandparents of Down patients. 61 56
3160646 1985
3
Evidence for genetic control of nondisjunction in man. 61 56
6446853 1980
4
Familial sex chromosomal mosaicism. 56
2240034 1990
5
The genetic basis of non-disjunction: increased incidence of hyperploidy in oocytes from F1 hybrid mice. 56
6642508 1983
6
Familial sex chromosome mosaicism (yes) and interchromosomal effects (no) 56
7460385 1981
7
The genetic control of meiosis. 56
797314 1976
8
Familial aneuploidy: what risk to sibs? 56
4407165 1974
9
Distributive pairing in man? 56
4999793 1971
10
Sex chromosome mosaicism in 3 sibs. Clinical and pathologic aspects. 56
4392643 1970
11
The presence of Turner's syndrome with 45,X karyotype in two generations. 56
5764188 1969
12
Satellite association and translocation mongolism. 56
4226331 1966
13
Satellite association (SA) in familial mosaicism. 56
5997618 1966
14
THE NONRANDOMNESS OF CHROMOSOMAL ABNORMALITIES. ASSOCIATION OF TRISOMY 18 AND DOWN'S SYNDROME. 56
14211000 1964
15
Mongolism. 56
13734151 1961
16
Hybridization Facilitates Adaptive Evolution in Two Major Fungal Pathogens. 61
31963231 2020
17
Multiregion exome sequencing of ovarian immature teratomas reveals 2N near-diploid genomes, paucity of somatic mutations, and extensive allelic imbalances shared across mature, immature, and disseminated components. 61
31911616 2020
18
The association between maternal occupation and down syndrome: A report from the national Down syndrome project. 61
31519426 2020
19
Mosaic Small Supernumerary Marker Chromosome Derived from Five Discontinuous Regions of Chromosome 8 in a Patient with Neutropenia and Oral Aphthous Ulcer. 61
31982875 2020
20
Resolvases, Dissolvases, and Helicases in Homologous Recombination: Clearing the Road for Chromosome Segregation. 61
31936378 2020
21
Evidence for the Oocyte Mosaicism Selection model on the origin of Patau syndrome (trisomy 13). 61
31464342 2019
22
A candidate gene analysis and GWAS for genes associated with maternal nondisjunction of chromosome 21. 61
31830031 2019
23
The maize B chromosome is capable of expressing microRNAs and altering the expression of microRNAs derived from A chromosomes. 61
31712937 2019
24
Characterization of Prevalence and Health Consequences of Uniparental Disomy in Four Million Individuals from the General Population. 61
31607426 2019
25
The failure of non-invasive prenatal testing due to maternal dermatomyositis. 61
31250459 2019
26
Adaptation by Loss of Heterozygosity in Saccharomyces cerevisiae Clones Under Divergent Selection. 61
31371407 2019
27
Increased levels of superoxide dismutase suppress meiotic segregation errors in aging oocytes. 61
31037468 2019
28
Chromosome errors in human eggs shape natural fertility over reproductive life span. 61
31604276 2019
29
Centromere-Proximal Meiotic Crossovers in Drosophila melanogaster Are Suppressed by Both Highly Repetitive Heterochromatin and Proximity to the Centromere. 61
31345993 2019
30
Nondisjunction and unequal spindle organization accompany the drive of Aegilops speltoides B chromosomes. 61
31038752 2019
31
Genome-wide Inference of Somatic Translocation Events During Potato Dihaploid Production. 61
31290929 2019
32
Site-specific transgenesis of the Drosophila melanogaster Y-chromosome using CRISPR/Cas9. 61
30079589 2019
33
Small supernumerary marker chromosomes: A legacy of trisomy rescue? 61
30412329 2019
34
Differentially expressed gene (DEG) based protein-protein interaction (PPI) network identifies a spectrum of gene interactome, transcriptome and correlated miRNA in nondisjunction Down syndrome. 61
30218739 2019
35
Meiotic nondisjunction and sperm aneuploidy in humans. 61
30390610 2019
36
Double Autosomal/Gonosomal Mosaic Trisomy 47,XXX/47,XX,+14 in a Newborn with Multiple Congenital Anomalies. 61
31786569 2019
37
In Vitro Mouse Lymphoma Cell (L5178Y Tk+/- -3.7.2.C) Forward Mutation Assay. 61
31473952 2019
38
Cryptococcus neoformans, Unlike Candida albicans, Forms Aneuploid Clones Directly from Uninucleated Cells under Fluconazole Stress. 61
30514783 2018
39
[Trisomy 18 in a bichorial-biamniotic twin pregnancy]. 61
30570236 2018
40
Risk of Down syndrome birth: Consanguineous marriage is associated with maternal meiosis-II nondisjunction at younger age and without any detectable recombination error. 61
30240118 2018
41
Spore-autonomous fluorescent protein expression identifies meiotic chromosome mis-segregation as the principal cause of hybrid sterility in yeast. 61
30419022 2018
42
Analysis of B chromosome nondisjunction induced by the r-X1 deficiency in maize. 61
29159670 2018
43
Reconstitution of anaphase DNA bridge recognition and disjunction. 61
30177760 2018
44
The budding yeast RSC complex maintains ploidy by promoting spindle pole body insertion. 61
29875260 2018
45
[Longer oral contraception history as a possible preventive factor against fetal trisomy 21 in advanced maternal age pregnancies]. 61
29983104 2018
46
Study of the effects of 0.15 terahertz radiation on genome integrity of adult fibroblasts. 61
29602275 2018
47
Regulation of the sperm-to-oocyte transition in Caenorhabditis briggsae hermaphrodites by the Cbr-met-2 and Cbr-fem-3 genes. 61
29693773 2018
48
Comparison of perinatal factors in deletion versus uniparental disomy in Prader-Willi syndrome. 61
29681103 2018
49
The Status of Genetic Screening in Recurrent Pregnancy Loss. 61
29428282 2018
50
A Genome Resequencing-Based Genetic Map Reveals the Recombination Landscape of an Outbred Parasitic Nematode in the Presence of Polyploidy and Polyandry. 61
29267942 2018

Variations for Nondisjunction

Expression for Nondisjunction

Search GEO for disease gene expression data for Nondisjunction.

Pathways for Nondisjunction

GO Terms for Nondisjunction

Biological processes related to Nondisjunction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 folic acid metabolic process GO:0046655 9.26 MTRR MTHFR
2 methionine biosynthetic process GO:0009086 9.16 MTRR MTHFR
3 homocysteine metabolic process GO:0050667 8.96 MTRR MTHFR
4 methionine metabolic process GO:0006555 8.62 MTRR MTHFR

Molecular functions related to Nondisjunction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 flavin adenine dinucleotide binding GO:0050660 9.16 MTRR MTHFR
2 NADP binding GO:0050661 8.96 MTRR MTHFR
3 FAD binding GO:0071949 8.62 MTRR MTHFR

Sources for Nondisjunction

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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