MCID: NNN001
MIFTS: 25

Nonencapsulated Sclerosing Carcinoma

Categories: Cancer diseases, Endocrine diseases

Aliases & Classifications for Nonencapsulated Sclerosing Carcinoma

MalaCards integrated aliases for Nonencapsulated Sclerosing Carcinoma:

Name: Nonencapsulated Sclerosing Carcinoma 12 15 71
Papillary Carcinoma, Diffuse Sclerosing 12
Nonencapsulated Sclerosing Neoplasm 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5914
SNOMED-CT 67 62681000
UMLS 71 C0334330

Summaries for Nonencapsulated Sclerosing Carcinoma

MalaCards based summary : Nonencapsulated Sclerosing Carcinoma, also known as papillary carcinoma, diffuse sclerosing, is related to papillary carcinoma and mechanical strabismus. An important gene associated with Nonencapsulated Sclerosing Carcinoma is LMNB2 (Lamin B2), and among its related pathways/superpathways are Cytoskeletal Signaling and Apoptosis and Autophagy. Affiliated tissues include thyroid, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Nonencapsulated Sclerosing Carcinoma

Diseases related to Nonencapsulated Sclerosing Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 105)
# Related Disease Score Top Affiliating Genes
1 papillary carcinoma 29.1 TPO TG RET CALCA
2 mechanical strabismus 10.2 TPO TG
3 familial thyroid dyshormonogenesis 10.1 TPO TG
4 iodine hypothyroidism 10.1 TPO TG
5 osteopoikilosis 10.1 LMNB2 LMNA
6 thyroid crisis 10.1 TPO TG
7 toxic diffuse goiter 10.1 TPO TG
8 goiter, multinodular 1, with or without sertoli-leydig cell tumors 10.1 TPO TG
9 subacute lymphocytic thyroiditis 10.1 TPO TG
10 plummer's disease 10.1 TPO TG
11 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.1 TPO TG
12 diabetes mellitus, insulin-dependent, 20 10.1 TPO TG
13 myxedema 10.1 TPO TG
14 subacute thyroiditis 10.1 TPO TG
15 hyperthyroxinemia 10.1 TPO TG
16 thyroid gland mucoepidermoid carcinoma 10.1 TG CALCA
17 premature menopause 10.0 TPO TG
18 spindle epithelial tumor with thymus-like differentiation tumor 10.0 TG CALCA
19 substernal goiter 10.0 TG CALCA
20 isthmus cancer 10.0 TG CALCA
21 fetal adenoma 10.0 TG CALCA
22 adrenal cortical hypofunction 10.0 TPO TG
23 carotid body cancer 10.0 TG CALCA
24 cardiomyopathy, dilated, 1h 10.0 LMNB2 LMNB1 LMNA
25 hypothyroidism, congenital, nongoitrous, 2 10.0 TPO TG
26 reynolds syndrome 10.0 LMNB2 LMNB1 LMNA
27 emery-dreifuss muscular dystrophy 3, autosomal recessive 10.0 LMNB2 LMNB1 LMNA
28 emery-dreifuss muscular dystrophy 10.0 LMNB2 LMNB1 LMNA
29 epithelial malignant thymoma 10.0 TG CALCA
30 charcot-marie-tooth disease, axonal, type 2b1 10.0 LMNB2 LMNB1 LMNA
31 pernicious anemia 10.0 TPO TG
32 emery-dreifuss muscular dystrophy 1, x-linked 10.0 LMNB2 LMNB1 LMNA
33 lipodystrophy, familial partial, type 5 10.0 LMNB2 LMNB1 LMNA
34 dendritic cell thymoma 10.0 TG CALCA
35 greenberg dysplasia 10.0 LMNB2 LMNB1 LMNA
36 leukodystrophy, demyelinating, adult-onset, autosomal dominant 10.0 LMNB2 LMNB1 LMNA
37 ectopic thymus 10.0 TG CALCA
38 cardiomyopathy, dilated, 1a 10.0 LMNB2 LMNB1 LMNA
39 buschke-ollendorff syndrome 10.0 LMNB2 LMNB1 LMNA
40 pelger-huet anomaly 10.0 LMNB2 LMNB1 LMNA
41 exophthalmos 10.0 TPO TG
42 nasal cavity olfactory neuroblastoma 10.0 TG CALCA
43 emery-dreifuss muscular dystrophy 2, autosomal dominant 10.0 LMNB2 LMNB1 LMNA
44 papillary thyroid microcarcinoma 10.0 TG CALCA
45 uterus leiomyosarcoma 10.0 TG CALCA
46 hutchinson-gilford progeria syndrome 10.0 LMNB2 LMNB1 LMNA
47 adrenal cortex disease 10.0 TPO TG
48 muscle tissue disease 9.9 LMNB2 LMNB1 LMNA
49 muscular dystrophy, congenital, lmna-related 9.9 LMNB2 LMNB1 LMNA
50 skin lipoma 9.9 TNS1 RET

Graphical network of the top 20 diseases related to Nonencapsulated Sclerosing Carcinoma:



Diseases related to Nonencapsulated Sclerosing Carcinoma

Symptoms & Phenotypes for Nonencapsulated Sclerosing Carcinoma

GenomeRNAi Phenotypes related to Nonencapsulated Sclerosing Carcinoma according to GeneCards Suite gene sharing:

26 (show all 12)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-112 9.44 LMNB1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-119 9.44 LMNA
3 Increased shRNA abundance (Z-score > 2) GR00366-A-131 9.44 LMNA LMNB1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-151 9.44 LMNA
5 Increased shRNA abundance (Z-score > 2) GR00366-A-171 9.44 TNS1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-173 9.44 LMNB1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-198 9.44 TNS1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-34 9.44 LMNA
9 Increased shRNA abundance (Z-score > 2) GR00366-A-72 9.44 TNS1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-75 9.44 TNS1
11 Increased shRNA abundance (Z-score > 2) GR00366-A-76 9.44 TNS1
12 Increased shRNA abundance (Z-score > 2) GR00366-A-91 9.44 LMNA

MGI Mouse Phenotypes related to Nonencapsulated Sclerosing Carcinoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.7 LMNA LMNB1 LMNB2 RET TERT TG
2 reproductive system MP:0005389 9.43 LMNA LMNB2 RET TERT TG TNS1
3 respiratory system MP:0005388 9.02 LMNA LMNB1 LMNB2 RET TERT

Drugs & Therapeutics for Nonencapsulated Sclerosing Carcinoma

Search Clinical Trials , NIH Clinical Center for Nonencapsulated Sclerosing Carcinoma

Genetic Tests for Nonencapsulated Sclerosing Carcinoma

Anatomical Context for Nonencapsulated Sclerosing Carcinoma

MalaCards organs/tissues related to Nonencapsulated Sclerosing Carcinoma:

40
Thyroid

Publications for Nonencapsulated Sclerosing Carcinoma

Articles related to Nonencapsulated Sclerosing Carcinoma:

# Title Authors PMID Year
1
Surgically Treated Pediatric Nonpapillary Thyroid Carcinoma. 61
26683804 2016
2
[Metastatic cardiac tamponade as initial manifestation of papillary thyroid carcinoma]. 61
22167730 2011
3
[Diffuse sclerosing papillary carcinoma mimicking chronic lymphocytic thyroiditis. A unusual neoplasm variant]. 61
16910389 2006
4
[Diffuse sclerosing papillary thyroid carcinoma. Report of two cases]. 61
9778875 1998
5
Clinical forms of presentation and evolution of diffuse sclerosing variant of papillary carcinoma and insular variant of follicular carcinoma of the thyroid. 61
9623728 1998

Variations for Nonencapsulated Sclerosing Carcinoma

Expression for Nonencapsulated Sclerosing Carcinoma

Search GEO for disease gene expression data for Nonencapsulated Sclerosing Carcinoma.

Pathways for Nonencapsulated Sclerosing Carcinoma

GO Terms for Nonencapsulated Sclerosing Carcinoma

Cellular components related to Nonencapsulated Sclerosing Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear membrane GO:0031965 9.43 LMNB2 LMNB1 LMNA
2 intermediate filament GO:0005882 9.33 LMNB2 LMNB1 LMNA
3 nuclear inner membrane GO:0005637 9.32 LMNB2 LMNB1
4 nuclear envelope GO:0005635 9.13 LMNB2 LMNB1 LMNA
5 lamin filament GO:0005638 8.8 LMNB2 LMNB1 LMNA

Biological processes related to Nonencapsulated Sclerosing Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to pain GO:0048265 9.16 RET CALCA
2 thyroid hormone generation GO:0006590 8.96 TPO TG
3 hormone biosynthetic process GO:0042446 8.62 TPO TG

Sources for Nonencapsulated Sclerosing Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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