MCID: NNN001
MIFTS: 26

Nonencapsulated Sclerosing Carcinoma

Categories: Cancer diseases, Endocrine diseases

Aliases & Classifications for Nonencapsulated Sclerosing Carcinoma

MalaCards integrated aliases for Nonencapsulated Sclerosing Carcinoma:

Name: Nonencapsulated Sclerosing Carcinoma 12 15 71
Papillary Carcinoma, Diffuse Sclerosing 12
Nonencapsulated Sclerosing Neoplasm 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5914
NCIt 49 C7427
SNOMED-CT 67 62681000
UMLS 71 C0334330

Summaries for Nonencapsulated Sclerosing Carcinoma

MalaCards based summary : Nonencapsulated Sclerosing Carcinoma, also known as papillary carcinoma, diffuse sclerosing, is related to papillary carcinoma and thyroid carcinoma. An important gene associated with Nonencapsulated Sclerosing Carcinoma is LMNB2 (Lamin B2), and among its related pathways/superpathways are Cytoskeletal Signaling and Apoptosis and Autophagy. Affiliated tissues include thyroid, thymus and t cells, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Nonencapsulated Sclerosing Carcinoma

Diseases related to Nonencapsulated Sclerosing Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 92)
# Related Disease Score Top Affiliating Genes
1 papillary carcinoma 29.0 TPO TG RET CALCA
2 thyroid carcinoma 28.7 TPO TG RET CALCA
3 emery-dreifuss muscular dystrophy 1, x-linked 10.1 LMNB1 LMNA
4 mechanical strabismus 10.1 TPO TG
5 iodine hypothyroidism 10.1 TPO TG
6 familial thyroid dyshormonogenesis 10.1 TPO TG
7 thyroid crisis 10.1 TPO TG
8 toxic diffuse goiter 10.1 TPO TG
9 goiter, multinodular 1, with or without sertoli-leydig cell tumors 10.0 TPO TG
10 subacute lymphocytic thyroiditis 10.0 TPO TG
11 cardiomyopathy, dilated, 1h 10.0 LMNB2 LMNB1 LMNA
12 reynolds syndrome 10.0 LMNB2 LMNB1 LMNA
13 emery-dreifuss muscular dystrophy 3, autosomal recessive 10.0 LMNB2 LMNB1 LMNA
14 hypothyroidism, congenital, nongoitrous, 2 10.0 TPO TG
15 emery-dreifuss muscular dystrophy 10.0 LMNB2 LMNB1 LMNA
16 charcot-marie-tooth disease, axonal, type 2b1 10.0 LMNB2 LMNB1 LMNA
17 lipodystrophy, familial partial, type 5 10.0 LMNB2 LMNB1 LMNA
18 thyroid cancer, nonmedullary, 1 10.0
19 thyroid gland papillary carcinoma 10.0
20 leukodystrophy, demyelinating, adult-onset, autosomal dominant 10.0 LMNB2 LMNB1 LMNA
21 cardiomyopathy, dilated, 1a 10.0 LMNB2 LMNB1 LMNA
22 pelger-huet anomaly 10.0 LMNB2 LMNB1 LMNA
23 plummer's disease 10.0 TPO TG
24 emery-dreifuss muscular dystrophy 2, autosomal dominant 10.0 LMNB2 LMNB1 LMNA
25 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.0 TPO TG
26 thyroid gland mucoepidermoid carcinoma 10.0 TG CALCA
27 diabetes mellitus, insulin-dependent, 20 10.0 TPO TG
28 hutchinson-gilford progeria syndrome 10.0 LMNB2 LMNB1 LMNA
29 thyroid sarcoma 10.0 TG CALCA
30 myxedema 10.0 TPO TG
31 spindle epithelial tumor with thymus-like differentiation tumor 10.0 TG CALCA
32 fetal adenoma 9.9 TG CALCA
33 muscle tissue disease 9.9 LMNB2 LMNB1 LMNA
34 subacute thyroiditis 9.9 TPO TG
35 carotid body cancer 9.9 TG CALCA
36 premature menopause 9.9 TPO TG
37 hypoadrenalism 9.9 TG CALCA
38 postpartum depression 9.9 TPO CALCA
39 epithelial malignant thymoma 9.9 TG CALCA
40 ectopic thymus 9.9 TG CALCA
41 adrenal cortical hypofunction 9.9 TPO TG
42 muscular dystrophy, congenital, lmna-related 9.9 LMNB2 LMNB1 LMNA
43 nasal cavity olfactory neuroblastoma 9.9 TG CALCA
44 papillary thyroid microcarcinoma 9.9 TG CALCA
45 pernicious anemia 9.9 TPO TG
46 exophthalmos 9.9 TPO TG
47 malignant pheochromocytoma 9.8 TERT CALCA
48 laryngeal neuroendocrine tumor 9.8 RET CALCA
49 multiple mucosal neuroma 9.8 RET CALCA
50 multicentric papillary thyroid carcinoma 9.7 TG RET

Graphical network of the top 20 diseases related to Nonencapsulated Sclerosing Carcinoma:



Diseases related to Nonencapsulated Sclerosing Carcinoma

Symptoms & Phenotypes for Nonencapsulated Sclerosing Carcinoma

GenomeRNAi Phenotypes related to Nonencapsulated Sclerosing Carcinoma according to GeneCards Suite gene sharing:

26 (show all 13)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-118 9.5 TNS1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-131 9.5 LMNA LMNB1 TNS1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-151 9.5 LMNA
4 Increased shRNA abundance (Z-score > 2) GR00366-A-173 9.5 LMNB1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-185 9.5 TNS1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-198 9.5 TNS1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-201 9.5 LMNB1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-208 9.5 LMNB1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.5 TNS1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-76 9.5 TNS1
11 Increased shRNA abundance (Z-score > 2) GR00366-A-81 9.5 LMNB1
12 Increased shRNA abundance (Z-score > 2) GR00366-A-88 9.5 LMNB1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-90 9.5 LMNA

MGI Mouse Phenotypes related to Nonencapsulated Sclerosing Carcinoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.5 LMNA LMNB1 LMNB2 RET TERT TG
2 respiratory system MP:0005388 9.02 LMNA LMNB1 LMNB2 RET TERT

Drugs & Therapeutics for Nonencapsulated Sclerosing Carcinoma

Search Clinical Trials , NIH Clinical Center for Nonencapsulated Sclerosing Carcinoma

Genetic Tests for Nonencapsulated Sclerosing Carcinoma

Anatomical Context for Nonencapsulated Sclerosing Carcinoma

MalaCards organs/tissues related to Nonencapsulated Sclerosing Carcinoma:

40
Thyroid, Thymus, T Cells

Publications for Nonencapsulated Sclerosing Carcinoma

Articles related to Nonencapsulated Sclerosing Carcinoma:

# Title Authors PMID Year
1
Surgically Treated Pediatric Nonpapillary Thyroid Carcinoma. 61
26683804 2016
2
[Metastatic cardiac tamponade as initial manifestation of papillary thyroid carcinoma]. 61
22167730 2011
3
[Diffuse sclerosing papillary carcinoma mimicking chronic lymphocytic thyroiditis. A unusual neoplasm variant]. 61
16910389 2006
4
[Diffuse sclerosing papillary thyroid carcinoma. Report of two cases]. 61
9778875 1998
5
Clinical forms of presentation and evolution of diffuse sclerosing variant of papillary carcinoma and insular variant of follicular carcinoma of the thyroid. 61
9623728 1998

Variations for Nonencapsulated Sclerosing Carcinoma

Expression for Nonencapsulated Sclerosing Carcinoma

Search GEO for disease gene expression data for Nonencapsulated Sclerosing Carcinoma.

Pathways for Nonencapsulated Sclerosing Carcinoma

GO Terms for Nonencapsulated Sclerosing Carcinoma

Cellular components related to Nonencapsulated Sclerosing Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear membrane GO:0031965 9.43 LMNB2 LMNB1 LMNA
2 intermediate filament GO:0005882 9.33 LMNB2 LMNB1 LMNA
3 nuclear inner membrane GO:0005637 9.32 LMNB2 LMNB1
4 nuclear envelope GO:0005635 9.13 LMNB2 LMNB1 LMNA
5 lamin filament GO:0005638 8.8 LMNB2 LMNB1 LMNA

Biological processes related to Nonencapsulated Sclerosing Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to pain GO:0048265 8.96 RET CALCA
2 hormone biosynthetic process GO:0042446 8.62 TPO TG

Sources for Nonencapsulated Sclerosing Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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