Nonencapsulated Sclerosing Carcinoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Nonencapsulated Sclerosing Carcinoma

MalaCards integrated aliases for Nonencapsulated Sclerosing Carcinoma:

Name: Nonencapsulated Sclerosing Carcinoma ¹² ¹⁵ ⁷¹

Papillary Carcinoma, Diffuse Sclerosing ¹²

Nonencapsulated Sclerosing Neoplasm ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Endocrine diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:5914

SNOMED-CT ⁶⁷ 62681000

UMLS ⁷¹ C0334330

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Summaries for Nonencapsulated Sclerosing Carcinoma

MalaCards based summary : Nonencapsulated Sclerosing Carcinoma, also known as papillary carcinoma, diffuse sclerosing, is related to papillary carcinoma and mechanical strabismus. An important gene associated with Nonencapsulated Sclerosing Carcinoma is LMNB2 (Lamin B2), and among its related pathways/superpathways are Cytoskeletal Signaling and Apoptosis and Autophagy. Affiliated tissues include thyroid, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

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Related Diseases for Nonencapsulated Sclerosing Carcinoma

Diseases related to Nonencapsulated Sclerosing Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 105)

#	Related Disease	Score	Top Affiliating Genes
1	papillary carcinoma	29.1	TPO TG RET CALCA
2	mechanical strabismus	10.2	TPO TG
3	familial thyroid dyshormonogenesis	10.1	TPO TG
4	iodine hypothyroidism	10.1	TPO TG
5	osteopoikilosis	10.1	LMNB2 LMNA
6	thyroid crisis	10.1	TPO TG
7	toxic diffuse goiter	10.1	TPO TG
8	goiter, multinodular 1, with or without sertoli-leydig cell tumors	10.1	TPO TG
9	subacute lymphocytic thyroiditis	10.1	TPO TG
10	plummer's disease	10.1	TPO TG
11	alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity	10.1	TPO TG
12	diabetes mellitus, insulin-dependent, 20	10.1	TPO TG
13	myxedema	10.1	TPO TG
14	subacute thyroiditis	10.1	TPO TG
15	hyperthyroxinemia	10.1	TPO TG
16	thyroid gland mucoepidermoid carcinoma	10.1	TG CALCA
17	premature menopause	10.0	TPO TG
18	spindle epithelial tumor with thymus-like differentiation tumor	10.0	TG CALCA
19	substernal goiter	10.0	TG CALCA
20	isthmus cancer	10.0	TG CALCA
21	fetal adenoma	10.0	TG CALCA
22	adrenal cortical hypofunction	10.0	TPO TG
23	carotid body cancer	10.0	TG CALCA
24	cardiomyopathy, dilated, 1h	10.0	LMNB2 LMNB1 LMNA
25	hypothyroidism, congenital, nongoitrous, 2	10.0	TPO TG
26	reynolds syndrome	10.0	LMNB2 LMNB1 LMNA
27	emery-dreifuss muscular dystrophy 3, autosomal recessive	10.0	LMNB2 LMNB1 LMNA
28	emery-dreifuss muscular dystrophy	10.0	LMNB2 LMNB1 LMNA
29	epithelial malignant thymoma	10.0	TG CALCA
30	charcot-marie-tooth disease, axonal, type 2b1	10.0	LMNB2 LMNB1 LMNA
31	pernicious anemia	10.0	TPO TG
32	emery-dreifuss muscular dystrophy 1, x-linked	10.0	LMNB2 LMNB1 LMNA
33	lipodystrophy, familial partial, type 5	10.0	LMNB2 LMNB1 LMNA
34	dendritic cell thymoma	10.0	TG CALCA
35	greenberg dysplasia	10.0	LMNB2 LMNB1 LMNA
36	leukodystrophy, demyelinating, adult-onset, autosomal dominant	10.0	LMNB2 LMNB1 LMNA
37	ectopic thymus	10.0	TG CALCA
38	cardiomyopathy, dilated, 1a	10.0	LMNB2 LMNB1 LMNA
39	buschke-ollendorff syndrome	10.0	LMNB2 LMNB1 LMNA
40	pelger-huet anomaly	10.0	LMNB2 LMNB1 LMNA
41	exophthalmos	10.0	TPO TG
42	nasal cavity olfactory neuroblastoma	10.0	TG CALCA
43	emery-dreifuss muscular dystrophy 2, autosomal dominant	10.0	LMNB2 LMNB1 LMNA
44	papillary thyroid microcarcinoma	10.0	TG CALCA
45	uterus leiomyosarcoma	10.0	TG CALCA
46	hutchinson-gilford progeria syndrome	10.0	LMNB2 LMNB1 LMNA
47	adrenal cortex disease	10.0	TPO TG
48	muscle tissue disease	9.9	LMNB2 LMNB1 LMNA
49	muscular dystrophy, congenital, lmna-related	9.9	LMNB2 LMNB1 LMNA
50	skin lipoma	9.9	TNS1 RET

Graphical network of the top 20 diseases related to Nonencapsulated Sclerosing Carcinoma:

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Symptoms & Phenotypes for Nonencapsulated Sclerosing Carcinoma

GenomeRNAi Phenotypes related to Nonencapsulated Sclerosing Carcinoma according to GeneCards Suite gene sharing:

²⁶ (show all 12)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased shRNA abundance (Z-score > 2)	GR00366-A-112	9.44	LMNB1
2	Increased shRNA abundance (Z-score > 2)	GR00366-A-119	9.44	LMNA
3	Increased shRNA abundance (Z-score > 2)	GR00366-A-131	9.44	LMNA LMNB1
4	Increased shRNA abundance (Z-score > 2)	GR00366-A-151	9.44	LMNA
5	Increased shRNA abundance (Z-score > 2)	GR00366-A-171	9.44	TNS1
6	Increased shRNA abundance (Z-score > 2)	GR00366-A-173	9.44	LMNB1
7	Increased shRNA abundance (Z-score > 2)	GR00366-A-198	9.44	TNS1
8	Increased shRNA abundance (Z-score > 2)	GR00366-A-34	9.44	LMNA
9	Increased shRNA abundance (Z-score > 2)	GR00366-A-72	9.44	TNS1
10	Increased shRNA abundance (Z-score > 2)	GR00366-A-75	9.44	TNS1
11	Increased shRNA abundance (Z-score > 2)	GR00366-A-76	9.44	TNS1
12	Increased shRNA abundance (Z-score > 2)	GR00366-A-91	9.44	LMNA

MGI Mouse Phenotypes related to Nonencapsulated Sclerosing Carcinoma:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	growth/size/body region	MP:0005378	9.7	LMNA LMNB1 LMNB2 RET TERT TG
2	reproductive system	MP:0005389	9.43	LMNA LMNB2 RET TERT TG TNS1
3	respiratory system	MP:0005388	9.02	LMNA LMNB1 LMNB2 RET TERT

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Drugs & Therapeutics for Nonencapsulated Sclerosing Carcinoma

Search Clinical Trials , NIH Clinical Center for Nonencapsulated Sclerosing Carcinoma

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Genetic Tests for Nonencapsulated Sclerosing Carcinoma

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Anatomical Context for Nonencapsulated Sclerosing Carcinoma

MalaCards organs/tissues related to Nonencapsulated Sclerosing Carcinoma:

⁴⁰

Thyroid

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Publications for Nonencapsulated Sclerosing Carcinoma

Articles related to Nonencapsulated Sclerosing Carcinoma:

#	Title	Authors	PMID	Year
1	Surgically Treated Pediatric Nonpapillary Thyroid Carcinoma. ⁶¹	Golpanian S...Perez EA	26683804	2016
2	[Metastatic cardiac tamponade as initial manifestation of papillary thyroid carcinoma]. ⁶¹	Riva V...Caballero Escuti G	22167730	2011
3	[Diffuse sclerosing papillary carcinoma mimicking chronic lymphocytic thyroiditis. A unusual neoplasm variant]. ⁶¹	Pino Rivero V...Blasco Huelva A	16910389	2006
4	[Diffuse sclerosing papillary thyroid carcinoma. Report of two cases]. ⁶¹	Trincado P...Michaud P	9778875	1998
5	Clinical forms of presentation and evolution of diffuse sclerosing variant of papillary carcinoma and insular variant of follicular carcinoma of the thyroid. ⁶¹	Albareda M...De Leiva A	9623728	1998

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Genes for Nonencapsulated Sclerosing Carcinoma

Genes related to Nonencapsulated Sclerosing Carcinoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	LMNB2	Lamin B2	Protein Coding	4.94	DISEASES inferred ¹⁵
2	LMNB1	Lamin B1	Protein Coding	4.58	DISEASES inferred ¹⁵
3	TPO	Thyroid Peroxidase	Protein Coding	4.54	DISEASES inferred ¹⁵
4	TNS1	Tensin 1	Protein Coding	4.46	DISEASES inferred ¹⁵
5	LMNA	Lamin A/C	Protein Coding	4.21	DISEASES inferred ¹⁵
6	TG	Thyroglobulin	Protein Coding	4.02	DISEASES inferred ¹⁵
7	TERT	Telomerase Reverse Transcriptase	Protein Coding	3.92	DISEASES inferred ¹⁵
8	RET	Ret Proto-Oncogene	Protein Coding	3.91	DISEASES inferred ¹⁵
9	CALCA	Calcitonin Related Polypeptide Alpha	Protein Coding	3.77	DISEASES inferred ¹⁵

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Variations for Nonencapsulated Sclerosing Carcinoma

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Expression for Nonencapsulated Sclerosing Carcinoma

Search GEO for disease gene expression data for Nonencapsulated Sclerosing Carcinoma.

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Pathways for Nonencapsulated Sclerosing Carcinoma

Pathways related to Nonencapsulated Sclerosing Carcinoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Cytoskeletal Signaling ⁴	12.07	LMNB2 LMNB1 LMNA
2	Apoptosis and Autophagy ⁴	11.7	LMNB2 LMNB1 LMNA
3	Apoptosis and survival Caspase cascade ²² Show member pathways Apoptosis and survival FAS signaling cascades ²² Breakdown of the nuclear lamina ⁶⁵ Caspase cascade in apoptosis ¹ Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation ¹ FasL/ CD95L signaling ⁶⁵ Influenza A virus infection ¹	11.59	LMNB2 LMNB1 LMNA
4	Neurodegenerative Diseases ⁶⁵ Show member pathways Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimers disease models ⁶⁵	11.03	LMNB1 LMNA
5	Initiation of Nuclear Envelope Reformation ⁶⁵ Show member pathways Clearance of Nuclear Envelope Membranes from Chromatin ⁶⁵ Nuclear Envelope Reassembly ⁶⁵	10.84	LMNB1 LMNA
6	Granzyme Pathway ⁶³ Show member pathways Granzyme-B Pathway ⁶³	10.52	LMNB2 LMNB1 LMNA
7	Thyroxine (Thyroid Hormone) Production ¹	9.73	TPO TG

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GO Terms for Nonencapsulated Sclerosing Carcinoma

Cellular components related to Nonencapsulated Sclerosing Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	nuclear membrane	GO:0031965	9.43	LMNB2 LMNB1 LMNA
2	intermediate filament	GO:0005882	9.33	LMNB2 LMNB1 LMNA
3	nuclear inner membrane	GO:0005637	9.32	LMNB2 LMNB1
4	nuclear envelope	GO:0005635	9.13	LMNB2 LMNB1 LMNA
5	lamin filament	GO:0005638	8.8	LMNB2 LMNB1 LMNA

Biological processes related to Nonencapsulated Sclerosing Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	response to pain	GO:0048265	9.16	RET CALCA
2	thyroid hormone generation	GO:0006590	8.96	TPO TG
3	hormone biosynthetic process	GO:0042446	8.62	TPO TG

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