Nonmucinous Bronchioloalveolar Adenocarcinoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Nonmucinous Bronchioloalveolar Adenocarcinoma

MalaCards integrated aliases for Nonmucinous Bronchioloalveolar Adenocarcinoma:

Name: Nonmucinous Bronchioloalveolar Adenocarcinoma ¹² ¹⁵

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Respiratory diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0080186

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Summaries for Nonmucinous Bronchioloalveolar Adenocarcinoma

Disease Ontology : ¹² A bronchiolo-alveolar adenocarcinoma that is characterized by cells with cuboidal or columnar morphology with eosinophilic or clear cytoplasm and shows Clara cell or type 2 pneumocyte differentiation.

MalaCards based summary : Nonmucinous Bronchioloalveolar Adenocarcinoma is related to mixed mucinous and nonmucinous bronchioloalveolar adenocarcinoma and atrophic vulva. An important gene associated with Nonmucinous Bronchioloalveolar Adenocarcinoma is KRT20 (Keratin 20), and among its related pathways/superpathways are Relaxin signaling pathway and TGF-beta Signaling Pathways. Related phenotype is Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435).

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Related Diseases for Nonmucinous Bronchioloalveolar Adenocarcinoma

Diseases related to Nonmucinous Bronchioloalveolar Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 88)

#	Related Disease	Score	Top Affiliating Genes
1	mixed mucinous and nonmucinous bronchioloalveolar adenocarcinoma	11.4
2	atrophic vulva	10.1	KRT20 ESR1
3	breast osteosarcoma	10.1	KRT20 ESR1
4	urethral benign neoplasm	10.1	KRT20 ESR1
5	breast neuroendocrine neoplasm	10.1	KRT20 ESR1
6	sweat gland cancer	10.1	KRT20 ESR1
7	tubular adenocarcinoma	10.0	KRT20 ESR1
8	mammary paget's disease	10.0	KRT20 ESR1
9	endocervical adenocarcinoma	10.0	KRT20 ESR1
10	cervical adenocarcinoma	10.0	KRT20 ESR1
11	mucinous bronchioloalveolar adenocarcinoma	10.0	NKX2-1 KRT20
12	thyroid angiosarcoma	10.0	NKX2-1 KRT20
13	thymus clear cell carcinoma	10.0	NKX2-1 KRT20
14	lung leiomyosarcoma	10.0	NKX2-1 KRT20
15	peritoneal serous adenocarcinoma	10.0	NKX2-1 KRT20
16	horseshoe kidney	10.0	NKX2-1 KRT20
17	papillary serous adenocarcinoma	10.0	NKX2-1 KRT20
18	cystic teratoma	10.0	NKX2-1 KRT20
19	teratoma	10.0	NKX2-1 KRT20
20	benign mesothelioma	10.0	NKX2-1 KRT20
21	large cell neuroendocrine carcinoma	10.0	NKX2-1 KRT20
22	neuroendocrine carcinoma	10.0	NKX2-1 KRT20
23	benign teratoma	10.0	NKX2-1 KRT20
24	bronchiolo-alveolar adenocarcinoma	10.0	NKX2-1 KRT20
25	cavernous hemangioma	10.0	NKX2-1 KRT20
26	thymic carcinoma	10.0	NKX2-1 KRT20
27	lung benign neoplasm	10.0	NKX2-1 KRT20
28	small cell carcinoma	10.0	NKX2-1 KRT20
29	merkel cell carcinoma	9.9	NKX2-1 KRT20
30	large cell carcinoma	9.9	NKX2-1 KRT20
31	oncocytoma	9.9	NKX2-1 KRT20
32	small cell cancer of the lung	9.9	NKX2-1 KRT20
33	follicular adenoma	9.9	NKX2-1 KRT20
34	bile duct cystadenoma	9.9	ESR2 ESR1
35	postmenopausal atrophic vaginitis	9.9	ESR2 ESR1
36	vaginitis	9.9	ESR2 ESR1
37	vaginal adenoma	9.9	KRT20 ESR2
38	vaginal benign neoplasm	9.9	KRT20 ESR2
39	gender identity disorder	9.9	ESR2 ESR1
40	progesterone resistance	9.9	ESR2 ESR1
41	vaginal cancer	9.9	ESR2 ESR1
42	progesterone-receptor positive breast cancer	9.9	ESR2 ESR1
43	estrogen excess	9.9	ESR2 ESR1
44	colorectal adenocarcinoma	9.9	NKX2-1 KRT20
45	dental fluorosis	9.9	ESR2 ESR1
46	endometriosis of ovary	9.9	ESR2 ESR1
47	lobular neoplasia	9.9	ESR2 ESR1
48	thoracic benign neoplasm	9.9	ESR2 ESR1
49	breast benign neoplasm	9.9	ESR2 ESR1
50	uterine benign neoplasm	9.9	ESR2 ESR1

Graphical network of the top 20 diseases related to Nonmucinous Bronchioloalveolar Adenocarcinoma:

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Symptoms & Phenotypes for Nonmucinous Bronchioloalveolar Adenocarcinoma

GenomeRNAi Phenotypes related to Nonmucinous Bronchioloalveolar Adenocarcinoma according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435)	GR00104-A-0	8.62	ESR1 ESR2

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Drugs & Therapeutics for Nonmucinous Bronchioloalveolar Adenocarcinoma

Search Clinical Trials , NIH Clinical Center for Nonmucinous Bronchioloalveolar Adenocarcinoma

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Genetic Tests for Nonmucinous Bronchioloalveolar Adenocarcinoma

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Anatomical Context for Nonmucinous Bronchioloalveolar Adenocarcinoma

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Publications for Nonmucinous Bronchioloalveolar Adenocarcinoma

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Genes for Nonmucinous Bronchioloalveolar Adenocarcinoma

Genes related to Nonmucinous Bronchioloalveolar Adenocarcinoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	KRT20	Keratin 20	Protein Coding	5.79	DISEASES inferred ¹⁵
2	NKX2-1	NK2 Homeobox 1	Protein Coding	5.49	DISEASES inferred ¹⁵
3	ESR2	Estrogen Receptor 2	Protein Coding	5.06	DISEASES inferred ¹⁵
4	ESR1	Estrogen Receptor 1	Protein Coding	4.33	DISEASES inferred ¹⁵

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Variations for Nonmucinous Bronchioloalveolar Adenocarcinoma

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Expression for Nonmucinous Bronchioloalveolar Adenocarcinoma

Search GEO for disease gene expression data for Nonmucinous Bronchioloalveolar Adenocarcinoma.

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Pathways for Nonmucinous Bronchioloalveolar Adenocarcinoma

Pathways related to Nonmucinous Bronchioloalveolar Adenocarcinoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Relaxin signaling pathway ³⁶ Show member pathways Estrogen signaling pathway ³⁶ Growth hormone synthesis, secretion and action ³⁶ Relaxin receptors ⁶⁵	12.09	KRT20 ESR2 ESR1
2	TGF-beta Signaling Pathways ⁶⁴	11.39	ESR2 ESR1
3	Nuclear Receptor transcription pathway ⁶⁵ Show member pathways Nuclear Receptors ¹	11.32	ESR2 ESR1
4	Apoptosis and survival_Anti-apoptotic action of nuclear ESR1 and ESR2 ²³	10.7	ESR2 ESR1
5	Plasma membrane estrogen receptor signaling ¹	10.57	ESR2 ESR1
6	MNAR-PELP1 and Estrogen Receptor Interaction ⁶³	10.32	ESR2 ESR1
7	Aromatase Inhibitor Pathway (Breast Cell), Pharmacodynamics ⁶⁰	9.23	ESR2 ESR1

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GO Terms for Nonmucinous Bronchioloalveolar Adenocarcinoma

Biological processes related to Nonmucinous Bronchioloalveolar Adenocarcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of transcription by RNA polymerase II	GO:0000122	9.54	NKX2-1 ESR2 ESR1
2	positive regulation of transcription, DNA-templated	GO:0045893	9.43	NKX2-1 ESR2 ESR1
3	positive regulation of DNA-binding transcription factor activity	GO:0051091	9.32	ESR2 ESR1
4	cellular response to estradiol stimulus	GO:0071392	9.16	ESR2 ESR1
5	intracellular estrogen receptor signaling pathway	GO:0030520	8.96	ESR2 ESR1
6	intracellular steroid hormone receptor signaling pathway	GO:0030518	8.62	ESR2 ESR1

Molecular functions related to Nonmucinous Bronchioloalveolar Adenocarcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	DNA-binding transcription factor activity	GO:0003700	9.61	NKX2-1 ESR2 ESR1
2	sequence-specific DNA binding	GO:0043565	9.54	NKX2-1 ESR2 ESR1
3	enzyme binding	GO:0019899	9.5	NKX2-1 ESR2 ESR1
4	nuclear receptor activity	GO:0004879	9.4	ESR2 ESR1
5	steroid binding	GO:0005496	9.26	ESR2 ESR1
6	steroid hormone receptor activity	GO:0003707	9.16	ESR2 ESR1
7	estrogen receptor activity	GO:0030284	8.96	ESR2 ESR1
8	estrogen response element binding	GO:0034056	8.62	ESR2 ESR1

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Sources for Nonmucinous Bronchioloalveolar Adenocarcinoma

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