Nonmucinous Bronchioloalveolar Adenocarcinoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Nonmucinous Bronchioloalveolar Adenocarcinoma

MalaCards integrated aliases for Nonmucinous Bronchioloalveolar Adenocarcinoma:

Name: Nonmucinous Bronchioloalveolar Adenocarcinoma ¹² ¹⁵

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Respiratory diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0080186

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Summaries for Nonmucinous Bronchioloalveolar Adenocarcinoma

Disease Ontology : ¹² A bronchiolo-alveolar adenocarcinoma that is characterized by cells with cuboidal or columnar morphology with eosinophilic or clear cytoplasm and shows Clara cell or type 2 pneumocyte differentiation.

MalaCards based summary : Nonmucinous Bronchioloalveolar Adenocarcinoma is related to mixed mucinous and nonmucinous bronchioloalveolar adenocarcinoma and colon adenocarcinoma. An important gene associated with Nonmucinous Bronchioloalveolar Adenocarcinoma is SLC27A5 (Solute Carrier Family 27 Member 5), and among its related pathways/superpathways are Relaxin signaling pathway and TGF-beta Signaling Pathways. Affiliated tissues include breast, lung and thyroid.

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Related Diseases for Nonmucinous Bronchioloalveolar Adenocarcinoma

Diseases related to Nonmucinous Bronchioloalveolar Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 75)

#	Related Disease	Score	Top Affiliating Genes
1	mixed mucinous and nonmucinous bronchioloalveolar adenocarcinoma	12.6
2	colon adenocarcinoma	10.3
3	adenocarcinoma	10.3
4	atrophic vulva	10.1	KRT20 ESR1
5	breast osteosarcoma	10.0	KRT20 ESR1
6	breast neuroendocrine neoplasm	10.0	KRT20 ESR1
7	in situ pulmonary adenocarcinoma	10.0	SLC27A5 NKX2-1
8	sweat gland cancer	10.0	KRT20 ESR1
9	endocervical adenocarcinoma	10.0	KRT20 ESR1
10	cervical adenocarcinoma	10.0	KRT20 ESR1
11	tubular adenocarcinoma	10.0	KRT20 ESR1
12	mammary paget's disease	10.0	KRT20 ESR1
13	clear cell adenocarcinoma	10.0	KRT20 ESR1
14	neuroendocrine carcinoma	10.0	NKX2-1 KRT20
15	small cell carcinoma	10.0	NKX2-1 KRT20
16	small cell carcinoma of the bladder	10.0	NKX2-1 KRT20
17	thymus clear cell carcinoma	10.0	NKX2-1 KRT20
18	thyroid angiosarcoma	10.0	NKX2-1 KRT20
19	lung acinar adenocarcinoma	10.0	NKX2-1 KRT20
20	horseshoe kidney	10.0	NKX2-1 KRT20
21	benign teratoma	10.0	NKX2-1 KRT20
22	papillary serous adenocarcinoma	10.0	NKX2-1 KRT20
23	ovary adenocarcinoma	9.9	KRT20 ESR1
24	cystic teratoma	9.9	NKX2-1 KRT20
25	thymic carcinoma	9.9	NKX2-1 KRT20
26	cavernous hemangioma	9.9	NKX2-1 KRT20
27	lung benign neoplasm	9.9	NKX2-1 KRT20
28	merkel cell carcinoma	9.9	NKX2-1 KRT20
29	large cell carcinoma	9.8	NKX2-1 KRT20
30	oncocytoma	9.8	NKX2-1 KRT20
31	alzheimer disease mitochondrial	9.8	ESR2 ESR1
32	progesterone resistance	9.8	ESR2 ESR1
33	gender identity disorder	9.8	ESR2 ESR1
34	estrogen excess	9.8	ESR2 ESR1
35	progesterone-receptor positive breast cancer	9.8	ESR2 ESR1
36	dental fluorosis	9.8	ESR2 ESR1
37	endometriosis of ovary	9.8	ESR2 ESR1
38	lobular neoplasia	9.8	ESR2 ESR1
39	vaginitis	9.8	ESR2 ESR1
40	testicular germ cell cancer	9.8	ESR2 ESR1
41	germ cell cancer	9.8	ESR2 ESR1
42	small cell cancer of the lung	9.8	NKX2-1 KRT20
43	uterine benign neoplasm	9.8	ESR2 ESR1
44	reproductive organ benign neoplasm	9.8	ESR2 ESR1
45	adenomyosis	9.8	ESR2 ESR1
46	pelvic organ prolapse	9.8	ESR2 ESR1
47	amelogenesis imperfecta, type ig	9.8	ESR2 ESR1
48	teeth hard tissue disease	9.8	ESR2 ESR1
49	colorectal adenocarcinoma	9.8	NKX2-1 KRT20
50	primary pigmented nodular adrenocortical disease	9.8	ESR2 ESR1

Graphical network of the top 20 diseases related to Nonmucinous Bronchioloalveolar Adenocarcinoma:

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Symptoms & Phenotypes for Nonmucinous Bronchioloalveolar Adenocarcinoma

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Drugs & Therapeutics for Nonmucinous Bronchioloalveolar Adenocarcinoma

Search Clinical Trials , NIH Clinical Center for Nonmucinous Bronchioloalveolar Adenocarcinoma

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Genetic Tests for Nonmucinous Bronchioloalveolar Adenocarcinoma

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Anatomical Context for Nonmucinous Bronchioloalveolar Adenocarcinoma

MalaCards organs/tissues related to Nonmucinous Bronchioloalveolar Adenocarcinoma:

⁴⁰

Breast, Lung, Thyroid, Ovary, Thymus, Colon, Kidney

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Publications for Nonmucinous Bronchioloalveolar Adenocarcinoma

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Genes for Nonmucinous Bronchioloalveolar Adenocarcinoma

Genes related to Nonmucinous Bronchioloalveolar Adenocarcinoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	SLC27A5	Solute Carrier Family 27 Member 5	Protein Coding	5.91	DISEASES inferred ¹⁵
2	KRT20	Keratin 20	Protein Coding	5.74	DISEASES inferred ¹⁵
3	NKX2-1	NK2 Homeobox 1	Protein Coding	5.45	DISEASES inferred ¹⁵
4	ESR2	Estrogen Receptor 2	Protein Coding	5.29	DISEASES inferred ¹⁵
5	ESR1	Estrogen Receptor 1	Protein Coding	4.37	DISEASES inferred ¹⁵

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Variations for Nonmucinous Bronchioloalveolar Adenocarcinoma

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Expression for Nonmucinous Bronchioloalveolar Adenocarcinoma

Search GEO for disease gene expression data for Nonmucinous Bronchioloalveolar Adenocarcinoma.

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Pathways for Nonmucinous Bronchioloalveolar Adenocarcinoma

Pathways related to Nonmucinous Bronchioloalveolar Adenocarcinoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Relaxin signaling pathway ³⁶ Show member pathways Estrogen signaling pathway ³⁶ Growth hormone synthesis, secretion and action ³⁶ Relaxin receptors ⁶⁵	12.09	KRT20 ESR2 ESR1
2	TGF-beta Signaling Pathways ⁶⁴	11.39	ESR2 ESR1
3	Nuclear Receptor transcription pathway ⁶⁵ Show member pathways Nuclear Receptors ¹	11.32	ESR2 ESR1
4	Apoptosis and survival_Anti-apoptotic action of nuclear ESR1 and ESR2 ²²	10.7	ESR2 ESR1
5	Plasma membrane estrogen receptor signaling ¹	10.57	ESR2 ESR1
6	MNAR-PELP1 and Estrogen Receptor Interaction ⁶³	10.32	ESR2 ESR1
7	Aromatase Inhibitor Pathway (Breast Cell), Pharmacodynamics ⁶⁰	9.23	ESR2 ESR1

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GO Terms for Nonmucinous Bronchioloalveolar Adenocarcinoma

Biological processes related to Nonmucinous Bronchioloalveolar Adenocarcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of DNA-binding transcription factor activity	GO:0051091	9.16	ESR2 ESR1
2	positive regulation of transcription, DNA-templated	GO:0045893	9.13	NKX2-1 ESR2 ESR1
3	intracellular estrogen receptor signaling pathway	GO:0030520	8.62	ESR2 ESR1

Molecular functions related to Nonmucinous Bronchioloalveolar Adenocarcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	sequence-specific DNA binding	GO:0043565	9.61	NKX2-1 ESR2 ESR1
2	RNA polymerase II proximal promoter sequence-specific DNA binding	GO:0000978	9.58	NKX2-1 ESR2 ESR1
3	enzyme binding	GO:0019899	9.43	NKX2-1 ESR2 ESR1
4	steroid hormone receptor activity	GO:0003707	9.37	ESR2 ESR1
5	nuclear receptor activity	GO:0004879	9.32	ESR2 ESR1
6	steroid binding	GO:0005496	9.16	ESR2 ESR1
7	estrogen receptor activity	GO:0030284	8.96	ESR2 ESR1
8	estrogen response element binding	GO:0034056	8.62	ESR2 ESR1

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Sources for Nonmucinous Bronchioloalveolar Adenocarcinoma

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