MCID: NNM008
MIFTS: 18

Nonmucinous Bronchioloalveolar Adenocarcinoma

Categories: Cancer diseases, Respiratory diseases

Aliases & Classifications for Nonmucinous Bronchioloalveolar Adenocarcinoma

MalaCards integrated aliases for Nonmucinous Bronchioloalveolar Adenocarcinoma:

Name: Nonmucinous Bronchioloalveolar Adenocarcinoma 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0080186

Summaries for Nonmucinous Bronchioloalveolar Adenocarcinoma

Disease Ontology : 12 A bronchiolo-alveolar adenocarcinoma that is characterized by cells with cuboidal or columnar morphology with eosinophilic or clear cytoplasm and shows Clara cell or type 2 pneumocyte differentiation.

MalaCards based summary : Nonmucinous Bronchioloalveolar Adenocarcinoma is related to mixed mucinous and nonmucinous bronchioloalveolar adenocarcinoma and atrophic vulva. An important gene associated with Nonmucinous Bronchioloalveolar Adenocarcinoma is KRT20 (Keratin 20), and among its related pathways/superpathways are Relaxin signaling pathway and TGF-beta Signaling Pathways. Related phenotype is Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435).

Related Diseases for Nonmucinous Bronchioloalveolar Adenocarcinoma

Diseases related to Nonmucinous Bronchioloalveolar Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 88)
# Related Disease Score Top Affiliating Genes
1 mixed mucinous and nonmucinous bronchioloalveolar adenocarcinoma 11.4
2 atrophic vulva 10.1 KRT20 ESR1
3 breast osteosarcoma 10.1 KRT20 ESR1
4 urethral benign neoplasm 10.1 KRT20 ESR1
5 breast neuroendocrine neoplasm 10.1 KRT20 ESR1
6 sweat gland cancer 10.1 KRT20 ESR1
7 tubular adenocarcinoma 10.0 KRT20 ESR1
8 mammary paget's disease 10.0 KRT20 ESR1
9 endocervical adenocarcinoma 10.0 KRT20 ESR1
10 cervical adenocarcinoma 10.0 KRT20 ESR1
11 mucinous bronchioloalveolar adenocarcinoma 10.0 NKX2-1 KRT20
12 thyroid angiosarcoma 10.0 NKX2-1 KRT20
13 thymus clear cell carcinoma 10.0 NKX2-1 KRT20
14 lung leiomyosarcoma 10.0 NKX2-1 KRT20
15 peritoneal serous adenocarcinoma 10.0 NKX2-1 KRT20
16 horseshoe kidney 10.0 NKX2-1 KRT20
17 papillary serous adenocarcinoma 10.0 NKX2-1 KRT20
18 cystic teratoma 10.0 NKX2-1 KRT20
19 teratoma 10.0 NKX2-1 KRT20
20 benign mesothelioma 10.0 NKX2-1 KRT20
21 large cell neuroendocrine carcinoma 10.0 NKX2-1 KRT20
22 neuroendocrine carcinoma 10.0 NKX2-1 KRT20
23 benign teratoma 10.0 NKX2-1 KRT20
24 bronchiolo-alveolar adenocarcinoma 10.0 NKX2-1 KRT20
25 cavernous hemangioma 10.0 NKX2-1 KRT20
26 thymic carcinoma 10.0 NKX2-1 KRT20
27 lung benign neoplasm 10.0 NKX2-1 KRT20
28 small cell carcinoma 10.0 NKX2-1 KRT20
29 merkel cell carcinoma 9.9 NKX2-1 KRT20
30 large cell carcinoma 9.9 NKX2-1 KRT20
31 oncocytoma 9.9 NKX2-1 KRT20
32 small cell cancer of the lung 9.9 NKX2-1 KRT20
33 follicular adenoma 9.9 NKX2-1 KRT20
34 bile duct cystadenoma 9.9 ESR2 ESR1
35 postmenopausal atrophic vaginitis 9.9 ESR2 ESR1
36 vaginitis 9.9 ESR2 ESR1
37 vaginal adenoma 9.9 KRT20 ESR2
38 vaginal benign neoplasm 9.9 KRT20 ESR2
39 gender identity disorder 9.9 ESR2 ESR1
40 progesterone resistance 9.9 ESR2 ESR1
41 vaginal cancer 9.9 ESR2 ESR1
42 progesterone-receptor positive breast cancer 9.9 ESR2 ESR1
43 estrogen excess 9.9 ESR2 ESR1
44 colorectal adenocarcinoma 9.9 NKX2-1 KRT20
45 dental fluorosis 9.9 ESR2 ESR1
46 endometriosis of ovary 9.9 ESR2 ESR1
47 lobular neoplasia 9.9 ESR2 ESR1
48 thoracic benign neoplasm 9.9 ESR2 ESR1
49 breast benign neoplasm 9.9 ESR2 ESR1
50 uterine benign neoplasm 9.9 ESR2 ESR1

Graphical network of the top 20 diseases related to Nonmucinous Bronchioloalveolar Adenocarcinoma:



Diseases related to Nonmucinous Bronchioloalveolar Adenocarcinoma

Symptoms & Phenotypes for Nonmucinous Bronchioloalveolar Adenocarcinoma

GenomeRNAi Phenotypes related to Nonmucinous Bronchioloalveolar Adenocarcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) GR00104-A-0 8.62 ESR1 ESR2

Drugs & Therapeutics for Nonmucinous Bronchioloalveolar Adenocarcinoma

Search Clinical Trials , NIH Clinical Center for Nonmucinous Bronchioloalveolar Adenocarcinoma

Genetic Tests for Nonmucinous Bronchioloalveolar Adenocarcinoma

Anatomical Context for Nonmucinous Bronchioloalveolar Adenocarcinoma

Publications for Nonmucinous Bronchioloalveolar Adenocarcinoma

Variations for Nonmucinous Bronchioloalveolar Adenocarcinoma

Expression for Nonmucinous Bronchioloalveolar Adenocarcinoma

Search GEO for disease gene expression data for Nonmucinous Bronchioloalveolar Adenocarcinoma.

Pathways for Nonmucinous Bronchioloalveolar Adenocarcinoma

GO Terms for Nonmucinous Bronchioloalveolar Adenocarcinoma

Biological processes related to Nonmucinous Bronchioloalveolar Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription by RNA polymerase II GO:0000122 9.54 NKX2-1 ESR2 ESR1
2 positive regulation of transcription, DNA-templated GO:0045893 9.43 NKX2-1 ESR2 ESR1
3 positive regulation of DNA-binding transcription factor activity GO:0051091 9.32 ESR2 ESR1
4 cellular response to estradiol stimulus GO:0071392 9.16 ESR2 ESR1
5 intracellular estrogen receptor signaling pathway GO:0030520 8.96 ESR2 ESR1
6 intracellular steroid hormone receptor signaling pathway GO:0030518 8.62 ESR2 ESR1

Molecular functions related to Nonmucinous Bronchioloalveolar Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription factor activity GO:0003700 9.61 NKX2-1 ESR2 ESR1
2 sequence-specific DNA binding GO:0043565 9.54 NKX2-1 ESR2 ESR1
3 enzyme binding GO:0019899 9.5 NKX2-1 ESR2 ESR1
4 nuclear receptor activity GO:0004879 9.4 ESR2 ESR1
5 steroid binding GO:0005496 9.26 ESR2 ESR1
6 steroid hormone receptor activity GO:0003707 9.16 ESR2 ESR1
7 estrogen receptor activity GO:0030284 8.96 ESR2 ESR1
8 estrogen response element binding GO:0034056 8.62 ESR2 ESR1

Sources for Nonmucinous Bronchioloalveolar Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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