Nonmucinous Bronchioloalveolar Adenocarcinoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Nonmucinous Bronchioloalveolar Adenocarcinoma

MalaCards integrated aliases for Nonmucinous Bronchioloalveolar Adenocarcinoma:

Name: Nonmucinous Bronchioloalveolar Adenocarcinoma ¹² ¹⁵

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Respiratory diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0080186

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Summaries for Nonmucinous Bronchioloalveolar Adenocarcinoma

Disease Ontology : ¹² A bronchiolo-alveolar adenocarcinoma that is characterized by cells with cuboidal or columnar morphology with eosinophilic or clear cytoplasm and shows Clara cell or type 2 pneumocyte differentiation.

MalaCards based summary : Nonmucinous Bronchioloalveolar Adenocarcinoma is related to colon adenocarcinoma and mixed mucinous and nonmucinous bronchioloalveolar adenocarcinoma. An important gene associated with Nonmucinous Bronchioloalveolar Adenocarcinoma is SLC27A5 (Solute Carrier Family 27 Member 5), and among its related pathways/superpathways are Circadian entrainment and TGF-beta Signaling Pathways.

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Related Diseases for Nonmucinous Bronchioloalveolar Adenocarcinoma

Diseases related to Nonmucinous Bronchioloalveolar Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 48)

#	Related Disease	Score	Top Affiliating Genes
1	colon adenocarcinoma	29.7	KRT20 ESR2
2	mixed mucinous and nonmucinous bronchioloalveolar adenocarcinoma	12.6
3	adenocarcinoma	10.3
4	glycogen-rich clear cell breast carcinoma	10.1	KRT20 ESR1
5	mammary paget's disease	10.1	KRT20 ESR1
6	small cell carcinoma	10.1	NKX2-1 KRT20
7	tubular adenocarcinoma	10.1	KRT20 ESR1
8	small cell carcinoma of the bladder	10.1	NKX2-1 KRT20
9	colloid adenoma	10.1	NKX2-1 KRT20
10	lung acinar adenocarcinoma	10.1	NKX2-1 KRT20
11	papillary serous adenocarcinoma	10.0	NKX2-1 KRT20
12	rete testis adenocarcinoma	10.0	NKX2-1 KRT20
13	cervical adenocarcinoma	10.0	KRT20 ESR1
14	sweat gland cancer	10.0	KRT20 ESR1
15	mucinous bronchioloalveolar adenocarcinoma	10.0	NKX2-1 KRT20
16	rete testis neoplasm	10.0	NKX2-1 KRT20
17	ovarian cystic teratoma	10.0	NKX2-1 KRT20
18	cystic teratoma	10.0	NKX2-1 KRT20
19	horseshoe kidney	10.0	NKX2-1 KRT20
20	hidradenocarcinoma	10.0	NKX2-1 ESR1
21	large cell neuroendocrine carcinoma	10.0	NKX2-1 KRT20
22	mucinous adenocarcinoma	10.0	NKX2-1 KRT20
23	bronchiolo-alveolar adenocarcinoma	10.0	NKX2-1 KRT20
24	merkel cell carcinoma	9.9	NKX2-1 KRT20
25	papillary carcinoma	9.9	NKX2-1 KRT20
26	postmenopausal atrophic vaginitis	9.9	ESR2 ESR1
27	vaginitis	9.9	ESR2 ESR1
28	progesterone-receptor positive breast cancer	9.9	ESR2 ESR1
29	progesterone resistance	9.9	ESR2 ESR1
30	gender identity disorder	9.9	ESR2 ESR1
31	estrogen excess	9.9	ESR2 ESR1
32	dental fluorosis	9.8	ESR2 ESR1
33	lobular neoplasia	9.8	ESR2 ESR1
34	endometriosis of ovary	9.8	ESR2 ESR1
35	endometriosis	9.8	ESR2 ESR1
36	mesothelioma, malignant	9.8	NKX2-1 KRT20
37	sporadic breast cancer	9.7	ESR2 ESR1
38	female reproductive system disease	9.7	ESR2 ESR1
39	neuroendocrine tumor	9.7	NKX2-1 KRT20
40	reproductive system disease	9.7	ESR2 ESR1
41	germ cell cancer	9.7	ESR2 ESR1
42	small cell cancer of the lung	9.7	NKX2-1 KRT20
43	endometrial adenocarcinoma	9.7	ESR2 ESR1
44	leiomyoma	9.6	ESR2 ESR1
45	thyroid carcinoma, familial medullary	9.5	NKX2-1 ESR2
46	ovarian disease	9.4	ESR2 ESR1
47	lung cancer susceptibility 3	9.2	NKX2-1 KRT20 ESR2
48	breast disease	9.2	ESR2 ESR1

Graphical network of the top 20 diseases related to Nonmucinous Bronchioloalveolar Adenocarcinoma:

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Symptoms & Phenotypes for Nonmucinous Bronchioloalveolar Adenocarcinoma

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Drugs & Therapeutics for Nonmucinous Bronchioloalveolar Adenocarcinoma

Search Clinical Trials , NIH Clinical Center for Nonmucinous Bronchioloalveolar Adenocarcinoma

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Genetic Tests for Nonmucinous Bronchioloalveolar Adenocarcinoma

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Anatomical Context for Nonmucinous Bronchioloalveolar Adenocarcinoma

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Publications for Nonmucinous Bronchioloalveolar Adenocarcinoma

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Genes for Nonmucinous Bronchioloalveolar Adenocarcinoma

Genes related to Nonmucinous Bronchioloalveolar Adenocarcinoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	SLC27A5	Solute Carrier Family 27 Member 5	Protein Coding	15.5	DISEASES inferred ¹⁵
2	KRT20	Keratin 20	Protein Coding	14.91	DISEASES inferred ¹⁵
3	NKX2-1	NK2 Homeobox 1	Protein Coding	14.69	DISEASES inferred ¹⁵
4	ESR2	Estrogen Receptor 2	Protein Coding	14.16	DISEASES inferred ¹⁵
5	ESR1	Estrogen Receptor 1	Protein Coding	13.4	DISEASES inferred ¹⁵

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Variations for Nonmucinous Bronchioloalveolar Adenocarcinoma

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Expression for Nonmucinous Bronchioloalveolar Adenocarcinoma

Search GEO for disease gene expression data for Nonmucinous Bronchioloalveolar Adenocarcinoma.

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Pathways for Nonmucinous Bronchioloalveolar Adenocarcinoma

Pathways related to Nonmucinous Bronchioloalveolar Adenocarcinoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Circadian entrainment ³⁷ Show member pathways Cholinergic synapse ³⁷ Dopaminergic synapse ³⁷ Estrogen signaling pathway ³⁷ Glutamatergic synapse ³⁷ Relaxin receptors ⁶⁶ Relaxin signaling pathway ³⁷ Synaptic Neurotransmission Pathways: Glutamatergic Excitation ⁶⁵	12.45	KRT20 ESR2 ESR1
2	TGF-beta Signaling Pathways ⁶⁵	11.35	ESR2 ESR1
3	Nuclear Receptor transcription pathway ⁶⁶ Show member pathways Nuclear Receptors ¹	11.28	ESR2 ESR1
4	Apoptosis and survival_Anti-apoptotic action of nuclear ESR1 and ESR2 ²²	10.7	ESR2 ESR1
5	Plasma membrane estrogen receptor signaling ¹	10.57	ESR2 ESR1
6	MNAR-PELP1 and Estrogen Receptor Interaction ⁶⁴	10.32	ESR2 ESR1
7	Aromatase Inhibitor Pathway (Breast Cell), Pharmacodynamics ⁶¹	9.23	ESR2 ESR1

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GO Terms for Nonmucinous Bronchioloalveolar Adenocarcinoma

Biological processes related to Nonmucinous Bronchioloalveolar Adenocarcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of transcription by RNA polymerase II	GO:0000122	9.43	NKX2-1 ESR2 ESR1
2	positive regulation of DNA-binding transcription factor activity	GO:0051091	9.16	ESR2 ESR1
3	positive regulation of transcription, DNA-templated	GO:0045893	9.13	NKX2-1 ESR2 ESR1
4	intracellular estrogen receptor signaling pathway	GO:0030520	8.62	ESR2 ESR1

Molecular functions related to Nonmucinous Bronchioloalveolar Adenocarcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	sequence-specific DNA binding	GO:0043565	9.61	NKX2-1 ESR2 ESR1
2	RNA polymerase II proximal promoter sequence-specific DNA binding	GO:0000978	9.58	NKX2-1 ESR2 ESR1
3	enzyme binding	GO:0019899	9.43	NKX2-1 ESR2 ESR1
4	steroid hormone receptor activity	GO:0003707	9.37	ESR2 ESR1
5	nuclear receptor activity	GO:0004879	9.32	ESR2 ESR1
6	steroid binding	GO:0005496	9.16	ESR2 ESR1
7	estrogen receptor activity	GO:0030284	8.96	ESR2 ESR1
8	estrogen response element binding	GO:0034056	8.62	ESR2 ESR1

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Sources for Nonmucinous Bronchioloalveolar Adenocarcinoma

¹ BioSystems

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