Nonsyndromic Deafness disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: NNS007 MIFTS: 35	Nonsyndromic Deafness Categories: Blood diseases, Cardiovascular diseases, Ear diseases, Fetal diseases, Genetic diseases, Neuronal diseases, Rare diseases
Genes Variations Tissues Related diseases Publications Expand all tables

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Aliases & Classifications for Nonsyndromic Deafness

MalaCards integrated aliases for Nonsyndromic Deafness:

Name: Nonsyndromic Deafness ⁷⁴ ²⁹ ⁶ ¹⁷ ⁷¹

Deafness, Nonsyndromic ³⁹

Classifications:

MalaCards categories:
Global: Genetic diseases Rare diseases Fetal diseases
Anatomical: Ear diseases Blood diseases Neuronal diseases Cardiovascular diseases

See all MalaCards categories (disease lists)

External Ids:

EFO ¹⁷ EFO_0009076

UMLS ⁷¹ C3711374

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Summaries for Nonsyndromic Deafness

MalaCards based summary : Nonsyndromic Deafness, also known as deafness, nonsyndromic, is related to autosomal recessive nonsyndromic deafness 3 and deafness, autosomal recessive 8. An important gene associated with Nonsyndromic Deafness is COL11A2 (Collagen Type XI Alpha 2 Chain). Affiliated tissues include testes, skin and retina, and related phenotypes are behavior/neurological and growth/size/body region

Wikipedia : ⁷⁴ Nonsyndromic deafness is hearing loss that is not associated with other signs and symptoms. In contrast,... more...

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Related Diseases for Nonsyndromic Deafness

Diseases in the Rare Deafness family:

Deafness, Autosomal Dominant 1	Deafness, Autosomal Recessive 1a
Deafness, Autosomal Recessive 2	Deafness, Autosomal Dominant 2a
Deafness, Autosomal Recessive 3	Deafness, Autosomal Dominant 4a
Deafness, Autosomal Recessive 5	Deafness, Autosomal Dominant 6
Deafness, Autosomal Recessive 6	Deafness, Autosomal Recessive 7
Deafness, Autosomal Dominant 5	Deafness, Autosomal Recessive 9
Deafness, Autosomal Recessive 8	Deafness, Autosomal Dominant 10
Deafness, Autosomal Dominant 11	Deafness, Autosomal Dominant 9
Deafness, Autosomal Recessive 12	Deafness, Autosomal Dominant 7
Deafness, Autosomal Dominant 12	Deafness, Autosomal Dominant 3a
Deafness, Autosomal Dominant 13	Deafness, Autosomal Recessive 15
Deafness, Autosomal Recessive 18a	Deafness, Autosomal Dominant 15
Deafness, Autosomal Recessive 17	Deafness, Autosomal Recessive 13
Deafness, Autosomal Dominant 17	Deafness, Autosomal Recessive 21
Deafness, Autosomal Recessive 14	Deafness, Autosomal Recessive 16
Deafness, Autosomal Dominant 16	Deafness, Autosomal Recessive 20
Deafness, Autosomal Dominant 20	Deafness, Autosomal Dominant 23
Deafness, Autosomal Recessive 26	Deafness, Autosomal Dominant 25
Deafness, Autosomal Recessive 27	Deafness, Autosomal Dominant 18
Deafness, Autosomal Dominant 24	Deafness, Autosomal Dominant 22
Deafness, Autosomal Dominant 30	Deafness, Autosomal Dominant 36
Deafness, Autosomal Dominant 21	Deafness, Autosomal Recessive 22
Deafness, Autosomal Recessive 31	Deafness, Autosomal Recessive 30
Deafness, Autosomal Recessive	Deafness, Autosomal Recessive 33
Deafness, Autosomal Dominant 44	Deafness, Autosomal Dominant 52
Deafness, Autosomal Recessive 37	Deafness, Autosomal Dominant 48
Deafness, Autosomal Recessive 38	Deafness, Autosomal Dominant 41
Deafness, Autosomal Recessive 40	Deafness, Autosomal Recessive 39
Deafness, Autosomal Dominant 49	Deafness, Autosomal Dominant 43
Deafness, Autosomal Recessive 35	Deafness, Autosomal Dominant 28
Deafness, Autosomal Dominant 31	Deafness, Autosomal Dominant 47
Deafness, Autosomal Recessive 48	Deafness, Autosomal Recessive 23
Deafness, Autosomal Recessive 42	Deafness, Autosomal Recessive 46
Deafness, Autosomal Recessive 53	Deafness, Autosomal Recessive 28
Deafness, Autosomal Recessive 51	Deafness, Autosomal Recessive 47
Deafness, Autosomal Recessive 55	Deafness, Autosomal Dominant 53
Deafness, Autosomal Recessive 62	Deafness, Autosomal Recessive 49
Deafness, Autosomal Recessive 44	Deafness, Autosomal Recessive 66
Deafness, Autosomal Recessive 59	Deafness, Autosomal Recessive 65
Deafness, Autosomal Recessive 67	Deafness, Autosomal Recessive 68
Deafness, Autosomal Recessive 24	Deafness, Autosomal Recessive 63
Deafness, Autosomal Dominant 27	Deafness, Autosomal Recessive 45
Deafness, Autosomal Dominant 59	Deafness, Autosomal Dominant 3b
Deafness, Autosomal Dominant 2b	Deafness, Autosomal Recessive 1b
Deafness, Autosomal Recessive 71	Deafness, Autosomal Dominant 50
Deafness, Autosomal Recessive 77	Deafness, Autosomal Recessive 25
Deafness, Autosomal Recessive 79	Deafness, Autosomal Recessive 84a
Deafness, Autosomal Recessive 85	Deafness, Autosomal Recessive 91
Deafness, Autosomal Dominant 51	Deafness, Autosomal Recessive 83
Deafness, Autosomal Recessive 74	Deafness, Autosomal Recessive 61
Deafness, Autosomal Recessive 89	Deafness, Autosomal Recessive 29
Deafness, Autosomal Dominant 64	Deafness, Autosomal Dominant 33
Deafness, Autosomal Recessive 96	Deafness, Autosomal Dominant 4b
Deafness, Autosomal Recessive 86	Deafness, Autosomal Recessive 98
Deafness, Autosomal Recessive 93	Deafness, Autosomal Recessive 70
Deafness, Autosomal Recessive 84b	Deafness, Autosomal Recessive 18b
Deafness, Autosomal Recessive 88	Deafness, Autosomal Recessive 76
Deafness, Autosomal Dominant 56	Deafness, Autosomal Dominant 54
Deafness, Autosomal Dominant 58	Deafness, Autosomal Recessive 101
Deafness, Autosomal Recessive 102	Deafness, Autosomal Recessive 103
Deafness, Autosomal Dominant 65	Deafness, Autosomal Dominant 67
Deafness, Autosomal Dominant 40	Deafness, Autosomal Recessive 104
Deafness, Autosomal Dominant 69	Deafness, Autosomal Recessive 97
Deafness, Autosomal Dominant 68	Deafness, Autosomal Dominant 70
Deafness, Autosomal Dominant 66	Deafness, Autosomal Dominant 71
Deafness, Autosomal Dominant 72	Deafness, Autosomal Recessive 106
Deafness, Autosomal Recessive 107	Deafness, Autosomal Recessive 108
Deafness, Autosomal Dominant 73	Deafness, Autosomal Recessive 57
Deafness, Autosomal Recessive 109	Deafness, Autosomal Recessive 110
Deafness, Autosomal Dominant 74	Deafness, Autosomal Recessive 111
Deafness, Autosomal Recessive 112	Deafness, Autosomal Recessive 113
Deafness, Autosomal Recessive 100	Deafness, Autosomal Recessive 94
Deafness, Autosomal Recessive 114	Deafness, Autosomal Recessive 115
Deafness, Autosomal Recessive 99	Deafness, Autosomal Dominant 37
Deafness, Autosomal Dominant 75	Deafness, Autosomal Dominant 76
Deafness, Autosomal Dominant 77	Autosomal Dominant Nonsyndromic Deafness
Autosomal Recessive Nonsyndromic Deafness	Autosomal Recessive Nonsyndromic Deafness 106
Autosomal Recessive Nonsyndromic Deafness 107	Autosomal Recessive Nonsyndromic Deafness 108
Autosomal Dominant Nonsyndromic Deafness 71	Autosomal Dominant Nonsyndromic Deafness 72
Autosomal Dominant Nonsyndromic Deafness 73	Autosomal Dominant Nonsyndromic Deafness 34
Autosomal Recessive Nonsyndromic Deafness 3	Autosomal Recessive Nonsyndromic Deafness 32
Autosomal Recessive Nonsyndromic Deafness 36	Nonsyndromic Deafness
Otof-Related Deafness	Familial Deafness

Diseases related to Nonsyndromic Deafness via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 238)

#	Related Disease	Score	Top Affiliating Genes
1	autosomal recessive nonsyndromic deafness 3	33.7	MYO15A LRTOMT GJB2
2	deafness, autosomal recessive 8	33.3	MYO15A GJB2
3	deafness, autosomal dominant 2a	33.2	KCNQ4 GJB2
4	deafness, autosomal recessive 63	33.2	MYO15A LRTOMT
5	deafness, autosomal recessive 49	33.2	MYO15A GJB2
6	deafness, autosomal recessive 79	33.2	MYO15A GJB2
7	deafness, autosomal dominant 17	33.2	MYO15A MYH9 KCNQ4
8	deafness, autosomal dominant 2b	33.1	KCNQ4 GJB2
9	deafness, autosomal dominant 64	33.1	KCNQ4 GJB2
10	deafness, autosomal recessive 93	33.1	LRTOMT GJB2
11	deafness, autosomal recessive 18a	33.1	PCDH15 MYO15A
12	deafness, autosomal dominant 41	33.1	KCNQ4 GJB2
13	deafness, autosomal recessive 1a	33.0	KCNQ4 GJB2
14	deafness, autosomal recessive 30	33.0	PCDH15 MYO15A
15	deafness, autosomal recessive 9	33.0	MYO15A GJB2
16	deafness, autosomal dominant 1	33.0	WFS1 MYO15A GJB2
17	deafness, autosomal recessive 35	32.9	MYO15A LRTOMT
18	deafness, autosomal recessive 7	32.9	MYO15A LRTOMT GJB2
19	deafness, autosomal recessive 23	32.9	PCDH15 MYO15A
20	deafness, autosomal recessive 1b	32.9	MYO15A GJB2
21	deafness, autosomal recessive 67	32.9	PCDH15 LRTOMT
22	deafness, autosomal recessive 24	32.9	MYO15A LRTOMT
23	deafness, autosomal recessive 2	32.7	PCDH15 MYO15A GJB2
24	autosomal recessive nonsyndromic deafness	32.7	PCDH15 OTOG MYO15A LRTOMT GJB2
25	deafness, autosomal dominant 36	32.7	PCDH15 MYO15A GJB2
26	deafness, autosomal recessive 12	32.7	PCDH15 MYO15A GJB2
27	deafness, autosomal dominant 12	32.6	OTOG COL11A2
28	deafness, autosomal dominant 44	32.6	KCNQ4 COL11A2
29	deafness, autosomal dominant 13	32.6	KCNQ4 COL11A2
30	deafness, autosomal recessive 84b	32.5	OTOG COL11A2
31	deafness, autosomal dominant 15	32.5	KCNQ4 COL11A2
32	deafness, autosomal dominant 10	32.5	KCNQ4 COL11A2
33	deafness, autosomal recessive 16	32.4	PCDH15 MYO15A GJB2
34	deafness, autosomal dominant 11	32.4	PCDH15 MYO15A GJB2
35	deafness, autosomal recessive 66	32.3	DCDC2 COL11A2
36	deafness, autosomal dominant 9	32.2	WFS1 KCNQ4 GJB2 COL11A2
37	deafness, autosomal recessive 53	32.2	OTOG LRTOMT COL11A2
38	deafness, autosomal dominant 6	32.1	WFS1 KCNQ4 GJB2 COL11A2
39	y-linked deafness	32.0	PCDH15 KCNQ4
40	deafness, autosomal recessive 21	31.7	OTOG MYO15A GJB2 COL11A2
41	nonsyndromic hearing loss	31.3	WFS1 PCDH15 MYO15A KCNQ4 GJB2
42	autosomal dominant nonsyndromic deafness	31.2	WFS1 PCDH15 OTOG MYO15A MYH9 KCNQ4
43	branchiootic syndrome 1	31.1	OTOG GJB2
44	dfnb1	30.5	PCDH15 GJB2
45	deafness, autosomal recessive 4, with enlarged vestibular aqueduct	30.4	PCDH15 MYO15A KCNQ4 GJB2 COL11A2
46	usher syndrome, type i	30.2	PCDH15 MYO15A GJB2
47	deafness, autosomal recessive 3	30.1	MYO15A GJB2
48	usher syndrome	30.0	PCDH15 MYO15A MYH9 GJB2
49	usher syndrome, type if	29.9	PCDH15 MYO15A
50	pendred syndrome	29.4	MYO15A MITF GJB2

Graphical network of the top 20 diseases related to Nonsyndromic Deafness:

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Symptoms & Phenotypes for Nonsyndromic Deafness

MGI Mouse Phenotypes related to Nonsyndromic Deafness:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	behavior/neurological	MP:0005386	9.86	COL11A2 DCDC2 LRTOMT MITF MYO15A OTOG
2	growth/size/body region	MP:0005378	9.76	COL11A2 GJB2 LRTOMT MITF MYH9 MYO15A
3	hearing/vestibular/ear	MP:0005377	9.61	COL11A2 GJB2 KCNQ4 LRTOMT MITF MYH9
4	nervous system	MP:0003631	9.28	DCDC2 GJB2 KCNQ4 LRTOMT MITF MYH9

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Drugs & Therapeutics for Nonsyndromic Deafness

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Genetic Analyses of Nonsyndromic and Syndromic Deafness in Pakistan	Recruiting	NCT00341874

Search NIH Clinical Center for Nonsyndromic Deafness

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Genetic Tests for Nonsyndromic Deafness

Genetic tests related to Nonsyndromic Deafness:

#	Genetic test	Affiliating Genes
1	Nonsyndromic Deafness ²⁹

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Anatomical Context for Nonsyndromic Deafness

MalaCards organs/tissues related to Nonsyndromic Deafness:

⁴⁰

Testes, Skin, Retina

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Publications for Nonsyndromic Deafness

Articles related to Nonsyndromic Deafness:

(show top 50) (show all 259)

#	Title	Authors	PMID	Year
1	The p.R206C Mutation in MYO7A Leads to Autosomal Dominant Nonsyndromic Hearing Loss. ⁶¹	Lu J...Wu H	32428919	2020
2	Whole exome sequencing identifies SCD5 as a novel causative gene for autosomal dominant nonsyndromic deafness. ⁶¹	Lu X...Liu Y	31972369	2020
3	Clinical and genetic study of 12 Chinese Han families with nonsyndromic deafness. ⁶¹	Wu D...Zhang L	32048449	2020
4	Noncoding Microdeletion in Mouse Hgf Disrupts Neural Crest Migration into the Stria Vascularis, Reduces the Endocochlear Potential, and Suggests the Neuropathology for Human Nonsyndromic Deafness DFNB39. ⁶¹	Morell RJ...Hoa M	32152201	2020
5	Functions of Vertebrate Ferlins. ⁶¹	Bulankina AV...Thoms S	32106631	2020
6	Tprn is essential for the integrity of stereociliary rootlet in cochlear hair cells in mice. ⁶¹	Men Y...Gao J	30159668	2019
7	Mutations in KARS cause a severe neurological and neurosensory disease with optic neuropathy. ⁶¹	Scheidecker S...Dollfus H	31116475	2019
8	A new microdeletion syndrome involving TBC1D24, ATP6V0C, and PDPK1 causes epilepsy, microcephaly, and developmental delay. ⁶¹	Mucha BE...Campeau PM	30245510	2019
9	Identification of four novel mutations in MYO7A gene and their association with nonsyndromic deafness and Usher Syndrome 1B. ⁶¹	Li Y...Zhu B	30826590	2019
10	Splice-altering variant in COL11A1 as a cause of nonsyndromic hearing loss DFNA37. ⁶¹	Booth KT...Smith SD	30245514	2019
11	A recurrent mutation in KCNQ4 in Korean families with nonsyndromic hearing loss and rescue of the channel activity by KCNQ activators. ⁶¹	Shin DH...Gee HY	30556268	2019
12	Mutational and phenotypic spectra of KCNE1 deficiency in Jervell and Lange-Nielsen Syndrome and Romano-Ward Syndrome. ⁶¹	Faridi R...Friedman TB	30461122	2019
13	Audiovestibular Phenotypes and Advanced Magnetic Resonance Imaging Features of Cochlin Gene Mutation Carriers. ⁶¹	Conte G...Di Berardino F	31390618	2019
14	Dysfunction of GRAP, encoding the GRB2-related adaptor protein, is linked to sensorineural hearing loss. ⁶¹	Li C...Tekin M	30610177	2019
15	Targeted next generation sequencing reveals OTOF mutations in auditory neuropathy spectrum disorder. ⁶¹	Chen K...Jiang H	30368385	2018
16	Whole-exome sequencing identifies two novel mutations in KCNQ4 in individuals with nonsyndromic hearing loss. ⁶¹	Jung J...Gee HY	30413759	2018
17	Aminoglycoside-associated nonsyndromic deafness and speech disorder in mitochondrial A1555G mutation in a family: A case report. ⁶¹	Ou YH...Liu CS	30335006	2018
18	[Analysis of audiological characteristics and genetic background in patients with nonsyndromic deafness and mitochondrial DNA 1555A>G mutation]. ⁶¹	Zhuo Y...Zheng B	30298482	2018
19	Structural plasticity of the HHD2 domain of whirlin. ⁶¹	Delhommel F...Wolff N	30053338	2018
20	Common and Founder Mutations for Monogenic Traits in Sub-Saharan African Populations. ⁶¹	Krause A...Ramsay M	30169122	2018
21	Chronic prenatal hypoxia impairs cochlear development, a mechanism involving connexin26 expression and promoter methylation. ⁶¹	Lin J...Zheng M	29207085	2018
22	Targeted Next-Generation Sequencing of a Deafness Gene Panel (MiamiOtoGenes) Analysis in Families Unsuitable for Linkage Analysis. ⁶¹	Shang H...Liu X	29568747	2018
23	A Novel p.G141R Mutation in ILDR1 Leads to Recessive Nonsyndromic Deafness DFNB42 in Two Chinese Han Families. ⁶¹	Wang X...Wu H	29849566	2018
24	Knock-In Mice with Myo3a Y137C Mutation Displayed Progressive Hearing Loss and Hair Cell Degeneration in the Inner Ear. ⁶¹	Li P...Gao J	30123247	2018
25	Prevalence of GJB2 Mutations in Affected Individuals from United Arab Emirates with Autosomal Recessive Nonsyndromic Hearing Loss. ⁶¹	Tlili A...Hadj Kacem H	29016196	2017
26	Hearing loss without overt metabolic acidosis in ATP6V1B1 deficient MRL mice, a new genetic model for non-syndromic deafness with enlarged vestibular aqueducts. ⁶¹	Tian C...Johnson KR	28934385	2017
27	Next-generation sequencing reveals the mutational landscape of clinically diagnosed Usher syndrome: copy number variations, phenocopies, a predominant target for translational read-through, and PEX26 mutated in Heimler syndrome. ⁶¹	Neuhaus C...Bolz HJ	28944237	2017
28	WFS1 and GJB2 mutations in patients with bilateral low-frequency sensorineural hearing loss. ⁶¹	Kasakura-Kimura N...Matsunaga T	28271504	2017
29	Mutation analysis of common GJB2, SCL26A4 and 12S rRNA genes among 380 deafness patients in northern China. ⁶¹	Pan J...Wang C	28583500	2017
30	Loss of CIB2 Causes Profound Hearing Loss and Abolishes Mechanoelectrical Transduction in Mice. ⁶¹	Wang Y...Xu Z	29255404	2017
31	Different Phenotypes of the Two Chinese Probands with the Same c.889G>A (p.C162Y) Mutation in COCH Gene Verify Different Mechanisms Underlying Autosomal Dominant Nonsyndromic Deafness 9. ⁶¹	Wang Q...Liu Y	28099493	2017
32	Noninvasive Test for Mitochondrial DNA A1555G Mutation Associated with Deafness. ⁶¹	Fan W...Xue L	28164482	2017
33	[Autosomal dominant hearing loss resulting from mutation in the GJB2 gene:nonsyndromic presentation in a Chinese family]. ⁶¹	Dai X...Cai WQ	29798269	2016
34	Progressive hearing loss and degeneration of hair cell stereocilia in taperin gene knockout mice. ⁶¹	Chen M...Xie DH	27693694	2016
35	Mutational Spectrum of MYO15A and the Molecular Mechanisms of DFNB3 Human Deafness. ⁶¹	Rehman AU...Friedman TB	27375115	2016
36	Reduction of Cellular Expression Levels Is a Common Feature of Functionally Affected Pendrin (SLC26A4) Protein Variants. ⁶¹	de Moraes VCS...Dossena S	26752218	2016
37	CORRIGENDUM: Comprehensive analysis via exome sequencing uncovers genetic etiology in autosomal recessive nonsyndromic deafness in a large multiethnic cohort. ⁶¹		27494218	2016
38	Genotypes and phenotypes of a family with a deaf child carrying combined heterozygous mutations in SLC26A4 and GJB3 genes. ⁶¹	Li Y...Zhu B	27176802	2016
39	Mutations in CDC14A, Encoding a Protein Phosphatase Involved in Hair Cell Ciliogenesis, Cause Autosomal-Recessive Severe to Profound Deafness. ⁶¹	Delmaghani S...Petit C	27259055	2016
40	Analysis of mitochondrial alterations in Brazilian patients with sensorineural hearing loss using MALDI-TOF mass spectrometry. ⁶¹	Alves RM...Sartorato EL	27230773	2016
41	Comprehensive analysis via exome sequencing uncovers genetic etiology in autosomal recessive nonsyndromic deafness in a large multiethnic cohort. ⁶¹	Bademci G...Tekin M	26226137	2016
42	Novel and recurrent CIB2 variants, associated with nonsyndromic deafness, do not affect calcium buffering and localization in hair cells. ⁶¹	Seco CZ...Kremer H	26173970	2016
43	Tauroursodeoxycholic acid prevents hearing loss and hair cell death in Cdh23(erl/erl) mice. ⁶¹	Hu J...Zheng QY	26748055	2016
44	A novel frameshift variant of COCH supports the hypothesis that haploinsufficiency is not a cause of autosomal dominant nonsyndromic deafness 9. ⁶¹	Masuda M...Matsunaga T	26631968	2016
45	NLRP3 Is Expressed in the Spiral Ganglion Neurons and Associated with Both Syndromic and Nonsyndromic Sensorineural Deafness. ⁶¹	Chen P...Wu H	27965898	2016
46	Auditory Pathology in a Transgenic mtTFB1 Mouse Model of Mitochondrial Deafness. ⁶¹	McKay SE...Shadel GS	26552864	2015
47	Prevalence of Deafness-Associated Connexin-26 (GJB2) and Connexin-30 (GJB6) Pathogenic Alleles in a Large Patient Cohort from Eastern Sicily. ⁶¹	Amorini M...Rigoli L	26096904	2015
48	Diversity of the causal genes in hearing impaired Algerian individuals identified by whole exome sequencing. ⁶¹	Ammar-Khodja F...Petit C	26029705	2015
49	Mutations of human NARS2, encoding the mitochondrial asparaginyl-tRNA synthetase, cause nonsyndromic deafness and Leigh syndrome. ⁶¹	Simon M...Riazuddin S	25807530	2015
50	Early-onset epileptic encephalopathy with hearing loss in two siblings with TBC1D24 recessive mutations. ⁶¹	Strazisar BG...Writzl K	25557349	2015

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Genes for Nonsyndromic Deafness

Genes related to Nonsyndromic Deafness (2 elite genes):

(show all 11)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	COL11A2	Collagen Type XI Alpha 2 Chain	Protein Coding	406.76	Pathogenic ⁶ GeneCards inferred via : Variants (show sections)
2	DCDC2	Doublecortin Domain Containing 2	Protein Coding	406.76	Pathogenic ⁶ GeneCards inferred via : Variants (show sections)
3	MYH9	Myosin Heavy Chain 9	Protein Coding	18.9	GeneCards inferred via : Publications Variants (show sections)
4	KCNQ4	Potassium Voltage-Gated Channel Subfamily Q Member 4	Protein Coding	17.21	GeneCards inferred via : Publications Variants (show sections)
5	LRTOMT	Leucine Rich Transmembrane And O-Methyltransferase Domain Containing	Protein Coding	15.82	GeneCards inferred via : Publications Summaries (show sections)
6	GJB2	Gap Junction Protein Beta 2	Protein Coding	15.81	GeneCards inferred via : Publications Variants (show sections)
7	OTOG	Otogelin	Protein Coding	15.66	GeneCards inferred via : Publications Summaries (show sections)
8	PCDH15	Protocadherin Related 15	Protein Coding	14.96	GeneCards inferred via : Publications Variants (show sections)
9	MITF	Melanocyte Inducing Transcription Factor	Protein Coding	14.47	GeneCards inferred via : Publications Variants (show sections)
10	WFS1	Wolframin ER Transmembrane Glycoprotein	Protein Coding	9.44	GeneCards inferred via : Variants (show sections)
11	MYO15A	Myosin XVA	Protein Coding	7.83	GeneCards inferred via : Publications (show sections)

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Variations for Nonsyndromic Deafness

ClinVar genetic disease variations for Nonsyndromic Deafness:

⁶ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎

#	Gene	Name	Type	Significance	ClinVarId	dbSNP ID	GRCh37 Pos	GRCh38 Pos
1	COL11A2	NM_080680.3(COL11A2):c.109G>T (p.Ala37Ser)	SNV	Pathogenic	160366	rs606231410	6:33157220-33157220	6:33189443-33189443
2	DCDC2	NM_016356.5(DCDC2):c.1271A>C (p.Gln424Pro)	SNV	Pathogenic	161160	rs794729665	6:24178613-24178613	6:24178385-24178385
3	PCDH15	NM_033056.4(PCDH15):c.4462_4469dup (p.Glu1491fs)	duplication	Likely pathogenic	432938	rs774056663	10:55583016-55583017	10:53823256-53823257
4	GJB2	NM_004004.6(GJB2):c.478G>A (p.Gly160Ser)	SNV	Conflicting interpretations of pathogenicity	44755	rs34988750	13:20763243-20763243	13:20189104-20189104
5	GJB2	NM_004004.6(GJB2):c.265C>T (p.Leu89Phe)	SNV	Uncertain significance	437829	rs765921870	13:20763456-20763456	13:20189317-20189317
6	MITF	NM_001354604.2(MITF):c.1031C>T (p.Pro344Leu)	SNV	Uncertain significance	800541		3:70005681-70005681	3:69956530-69956530

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Expression for Nonsyndromic Deafness

Search GEO for disease gene expression data for Nonsyndromic Deafness.

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Pathways for Nonsyndromic Deafness

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GO Terms for Nonsyndromic Deafness

Cellular components related to Nonsyndromic Deafness according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	myosin complex	GO:0016459	8.96	MYO15A MYH9
2	stereocilium	GO:0032420	8.62	PCDH15 MYO15A

Biological processes related to Nonsyndromic Deafness according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	sensory perception of sound	GO:0007605	9.28	WFS1 PCDH15 OTOG MYO15A LRTOMT KCNQ4
2	inner ear development	GO:0048839	8.96	PCDH15 GJB2

Molecular functions related to Nonsyndromic Deafness according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	microfilament motor activity	GO:0000146	9.16	MYO15A MYH9
2	actin-dependent ATPase activity	GO:0030898	8.96	MYO15A MYH9
3	calmodulin binding	GO:0005516	8.92	WFS1 MYO15A MYH9 KCNQ4

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Sources for Nonsyndromic Deafness

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NIH Rare Diseases

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia