MCID: NNS019
MIFTS: 14

Nonsyndromic Holoprosencephaly

Categories: Genetic diseases, Neuronal diseases, Rare diseases, Endocrine diseases, Fetal diseases

Aliases & Classifications for Nonsyndromic Holoprosencephaly

MalaCards integrated aliases for Nonsyndromic Holoprosencephaly:

Name: Nonsyndromic Holoprosencephaly 25 73
Non-Syndromic, Non-Chromosomal Holoprosencephaly 25
Non-Syndromic, Non-Chromosomal Hpe 25
Holoprosencephaly Sequence 25
Isolated Holoprosencephaly 25
Nonsyndromic Hpe 25
Isolated Hpe 25

Classifications:



External Ids:

UMLS 73 C3711749

Summaries for Nonsyndromic Holoprosencephaly

Genetics Home Reference : 25 Nonsyndromic holoprosencephaly is an abnormality of brain development that also affects the head and face. Normally, the brain divides into two halves (hemispheres) during early development. Holoprosencephaly occurs when the brain fails to divide properly into the right and left hemispheres. This condition is called nonsyndromic to distinguish it from other types of holoprosencephaly caused by genetic syndromes, chromosome abnormalities, or substances that cause birth defects (teratogens). The severity of nonsyndromic holoprosencephaly varies widely among affected individuals, even within the same family.

MalaCards based summary : Nonsyndromic Holoprosencephaly, also known as non-syndromic, non-chromosomal holoprosencephaly, is related to holoprosencephaly. Affiliated tissues include brain.

Related Diseases for Nonsyndromic Holoprosencephaly

Diseases in the Holoprosencephaly family:

Holoprosencephaly 3 Holoprosencephaly 4
Holoprosencephaly 2 Holoprosencephaly 1
Holoprosencephaly 6 Holoprosencephaly 8
Holoprosencephaly 5 Holoprosencephaly 7
Holoprosencephaly 9 Holoprosencephaly 11
Nonsyndromic Holoprosencephaly

Diseases related to Nonsyndromic Holoprosencephaly via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 holoprosencephaly 10.1

Symptoms & Phenotypes for Nonsyndromic Holoprosencephaly

Drugs & Therapeutics for Nonsyndromic Holoprosencephaly

Search Clinical Trials , NIH Clinical Center for Nonsyndromic Holoprosencephaly

Genetic Tests for Nonsyndromic Holoprosencephaly

Anatomical Context for Nonsyndromic Holoprosencephaly

MalaCards organs/tissues related to Nonsyndromic Holoprosencephaly:

41
Brain

Publications for Nonsyndromic Holoprosencephaly

Articles related to Nonsyndromic Holoprosencephaly:

# Title Authors Year
1
Extracephalic manifestations of nonchromosomal, nonsyndromic holoprosencephaly. ( 29761634 )
2018
2
Risk factors for nonsyndromic holoprosencephaly: a Manitoba case-control study. ( 22419615 )
2012
3
Segregation analysis in nonsyndromic holoprosencephaly. ( 9605287 )
1998

Variations for Nonsyndromic Holoprosencephaly

Expression for Nonsyndromic Holoprosencephaly

Search GEO for disease gene expression data for Nonsyndromic Holoprosencephaly.

Pathways for Nonsyndromic Holoprosencephaly

GO Terms for Nonsyndromic Holoprosencephaly

Sources for Nonsyndromic Holoprosencephaly

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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