MCID: NNT010
MIFTS: 36

Nontoxic Goiter

Categories: Endocrine diseases

Aliases & Classifications for Nontoxic Goiter

MalaCards integrated aliases for Nontoxic Goiter:

Name: Nontoxic Goiter 12 55 15 73
Nodule-Thyroid, Non Tox 12
Non-Toxic Simple Goitre 12
Goiter, Non-Toxic 12
Goitre, Non-Toxic 12
Non-Toxic Goitre 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13195
NCIt 50 C35271
UMLS 73 C0221777

Summaries for Nontoxic Goiter

MalaCards based summary : Nontoxic Goiter, also known as nodule-thyroid, non tox, is related to goiter, multinodular 1, with or without sertoli-leydig cell tumors and plummer's disease. An important gene associated with Nontoxic Goiter is TG (Thyroglobulin), and among its related pathways/superpathways are Aldosterone synthesis and secretion and Allograft rejection. The drugs Salmon Calcitonin and Calcitonin gene-related peptide have been mentioned in the context of this disorder. Affiliated tissues include thyroid, bone and testes, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Nontoxic Goiter

Diseases related to Nontoxic Goiter via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 77)
# Related Disease Score Top Affiliating Genes
1 goiter, multinodular 1, with or without sertoli-leydig cell tumors 32.6 TG TPO
2 plummer's disease 30.0 SHBG TG TPO
3 myxedema 29.7 TG TPO TSHR
4 nodular goiter 28.3 CALCA TG TPO TSHR
5 graves' disease 28.3 FASLG SERPINA7 TG TPO TSHR
6 thyroid cancer 28.2 CALCA TG TPO TSHR
7 goiter 28.1 BGLAP CALCA SERPINA7 TG TPO TSHR
8 hyperthyroidism 27.5 BGLAP SERPINA7 SHBG TG TPO TSHR
9 thyroiditis 27.2 CALCA FASLG SERPINA7 TG TPO TSHR
10 familial thyroid dyshormonogenesis 10.5 TG TPO
11 subacute lymphocytic thyroiditis 10.5 TG TPO
12 premature menopause 10.4 TG TPO
13 nutritional deficiency disease 10.4 BGLAP TG
14 hypothyroidism, congenital, nongoitrous, 4 10.4 TG TPO
15 pernicious anemia 10.4 TG TPO
16 hypothyroidism, thyroidal or athyroidal, with spiky hair and cleft palate 10.4 TG TPO
17 benign struma ovarii 10.4 TG TSHR
18 dyshormonogenic goiter 10.4 SERPINA7 TG
19 athyreosis 10.4 TG TSHR
20 struma ovarii 10.4 TG TSHR
21 exophthalmos 10.3 TG TSHR
22 anaplastic thyroid cancer 10.3 TG TPO
23 pendred syndrome 10.2 TG TPO
24 mucoepidermoid thyroid carcinoma 10.1 CALCA TG
25 suppurative thyroiditis 10.1 CALCA TG
26 thyroid sarcoma 10.1 CALCA TG
27 atypical follicular adenoma 10.0 CALCA TG
28 acute thyroiditis 10.0 CALCA TG
29 osteitis fibrosa 10.0 BGLAP CALCA
30 osteoporosis, juvenile 10.0 BGLAP CALCA
31 amyloid tumor 10.0 CALCA TG
32 ovarian cystic teratoma 10.0 CALCA TG
33 hypophosphatasia, adult 10.0 BGLAP CALCA
34 thyroid hormone resistance, generalized, autosomal dominant 10.0 SERPINA7 SHBG TG
35 glucocorticoid-induced osteoporosis 9.9 BGLAP CALCA
36 secondary hyperparathyroidism of renal origin 9.9 BGLAP CALCA
37 aging 9.9
38 respiratory failure 9.9
39 cervicitis 9.9
40 neonatal hypothyroidism 9.9 TG TPO TSHR
41 parathyroid gland disease 9.9 BGLAP CALCA
42 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 9.9 TG TPO TSHR
43 renal osteodystrophy 9.9 BGLAP CALCA
44 hypersensitivity reaction disease 9.9 TG TPO TSHR
45 congenital hypothyroidism 9.9 TG TPO TSHR
46 fibrous dysplasia 9.9 BGLAP CALCA
47 bone resorption disease 9.9 BGLAP CALCA
48 hemiplegia 9.9 BGLAP CALCA
49 bone remodeling disease 9.8 BGLAP CALCA
50 hypothyroidism, congenital, nongoitrous, 2 9.8 SERPINA7 TG TSHR

Graphical network of the top 20 diseases related to Nontoxic Goiter:



Diseases related to Nontoxic Goiter

Symptoms & Phenotypes for Nontoxic Goiter

GenomeRNAi Phenotypes related to Nontoxic Goiter according to GeneCards Suite gene sharing:

26 (show all 17)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-113 9.6 BGLAP
2 Increased shRNA abundance (Z-score > 2) GR00366-A-124 9.6 BGLAP
3 Increased shRNA abundance (Z-score > 2) GR00366-A-126 9.6 BGLAP
4 Increased shRNA abundance (Z-score > 2) GR00366-A-140 9.6 TPO
5 Increased shRNA abundance (Z-score > 2) GR00366-A-147 9.6 BGLAP
6 Increased shRNA abundance (Z-score > 2) GR00366-A-16 9.6 BGLAP
7 Increased shRNA abundance (Z-score > 2) GR00366-A-164 9.6 BGLAP
8 Increased shRNA abundance (Z-score > 2) GR00366-A-166 9.6 BGLAP
9 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.6 BGLAP SHBG TPO
10 Increased shRNA abundance (Z-score > 2) GR00366-A-178 9.6 BGLAP
11 Increased shRNA abundance (Z-score > 2) GR00366-A-207 9.6 SHBG
12 Increased shRNA abundance (Z-score > 2) GR00366-A-30 9.6 TPO
13 Increased shRNA abundance (Z-score > 2) GR00366-A-45 9.6 SHBG
14 Increased shRNA abundance (Z-score > 2) GR00366-A-46 9.6 SHBG
15 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.6 TPO
16 Increased shRNA abundance (Z-score > 2) GR00366-A-56 9.6 TPO
17 Increased shRNA abundance (Z-score > 2) GR00366-A-69 9.6 SHBG

Drugs & Therapeutics for Nontoxic Goiter

Drugs for Nontoxic Goiter (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Salmon Calcitonin Approved, Investigational Phase 2 47931-85-1 16129616
2
Calcitonin gene-related peptide Investigational Phase 2 83652-28-2
3 Bone Density Conservation Agents Phase 2
4 calcitonin Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 rhTSH, Thyroid Size, and Radioiodine Therapy in Benign Goiter Completed NCT00145366 Phase 2 Recombinant human thyrotropin (Thyrogen)
2 ThyrOp: A Study of Individual Subclinical Hypothyroidism After Hemithyroidectomy for Benign Nontoxic Goiter Unknown status NCT01358136
3 Changes in Quality of Life Following Surgical Treatment of Benign Non-toxic Goiter Completed NCT02651818
4 Outcomes of Different Thyroid Resections for Multinodular Non-toxic Goiter Completed NCT00946894 Not Applicable
5 Goitres Influence on Voice Function - The Impact of Surgery Active, not recruiting NCT02468921

Search NIH Clinical Center for Nontoxic Goiter

Genetic Tests for Nontoxic Goiter

Anatomical Context for Nontoxic Goiter

MalaCards organs/tissues related to Nontoxic Goiter:

41
Thyroid, Bone, Testes

Publications for Nontoxic Goiter

Articles related to Nontoxic Goiter:

(show top 50) (show all 64)
# Title Authors Year
1
Nontoxic Goiter (NTG) and Radioiodine: What Do Patients Think About It? Quality of Life in Patients with NTG Before and After 131-I Therapy. ( 29713309 )
2018
2
Increased Cardiovascular Mortality and Morbidity in Patients Treated for Toxic Nodular Goiter Compared to Graves' Disease and Nontoxic Goiter. ( 28471268 )
2017
3
Total Thyroidectomy versus Bilateral Subtotal Thyroidectomy for Bilateral Multinodular Nontoxic Goiter: A Meta-Analysis. ( 27256349 )
2016
4
Quality of life in patients with benign nontoxic goiter: impact of disease and treatment response, and comparison with the general population. ( 25602312 )
2015
5
Detection of heterozygous c.1708C>T and c.1978C>G thyroid peroxidase (TPO) mutations in Iraqi patients with toxic and nontoxic goiter. ( 24482635 )
2014
6
Incidental thyroid cancer in toxic and nontoxic goiter: Is TSH associated with malignanCy rate? Results of a meta-analysis. ( 23186976 )
2013
7
Prestimulation with recombinant human thyrotropin (rhTSH) improves the long-term outcome of radioiodine therapy for multinodular nontoxic goiter. ( 22577172 )
2012
8
Total thyroidectomy: is morbidity higher for Graves' disease than nontoxic goiter? ( 21550063 )
2011
9
Acute respiratory failure caused by neglected giant substernal nontoxic goiter. ( 21655873 )
2011
10
Does unilateral lobectomy suffice to manage unilateral nontoxic goiter? ( 19703811 )
2010
11
Five-year follow-up of a randomized clinical trial of total thyroidectomy versus Dunhill operation versus bilateral subtotal thyroidectomy for multinodular nontoxic goiter. ( 20174803 )
2010
12
Radioiodine treatment of Plummer and multinodular toxic and nontoxic goiter disease by the first approximation dosimetry method. ( 17600473 )
2007
13
Metastasis as presenting feature of thyroid follicular carcinoma; report of a patient thyroidectomized for benign multinodular nontoxic goiter. ( 16029132 )
2005
14
Evaluation and treatment of sporadic nontoxic goiter--some answers and more questions. ( 11238475 )
2001
15
A randomized trial comparing levothyroxine with radioactive iodine in the treatment of sporadic nontoxic goiter. ( 11238476 )
2001
16
The effect of iodine administration on the development of thyroid autoimmunity in patients with nontoxic goiter. ( 10907993 )
2000
17
Increased major histocompatibility complex (MHC) expression in nontoxic goiters is associated with iodide depletion, enhanced ability of the follicular thyroglobulin to increase MHC gene expression, and thyroid autoantibodies. ( 10690902 )
2000
18
Is routine thyroxine treatment to hinder postoperative recurrence of nontoxic goiter justified? ( 10022449 )
1999
19
Postural changes of the cervical spine in patients with nontoxic goiter. ( 9868630 )
1998
20
Thyrotropin receptor antibodies and Graves' disease, a side-effect of 131I treatment in patients with nontoxic goiter. ( 9284721 )
1997
21
Iodine-131 therapy in sporadic nontoxic goiter. ( 9074521 )
1997
22
Long-term observation of serum thyroglobulin after resection of nontoxic goiter and relation to ultrasonographically demonstrated relapse. ( 8661844 )
1996
23
Improvement of upper airway obstruction after 131I-treatment of multinodular nontoxic goiter evaluated by flow volume loop curves. ( 8778168 )
1996
24
Radioiodine uptake as a function of stored iodine and thyroglobulin in thyroid follicles: in vitro quantitative imaging approach with secondary ion mass spectrometry (SIMS) microscopy in human nontoxic goiter. ( 7920005 )
1994
25
Bone metabolism in premenopausal women with nontoxic goiter and reduced serum thyrotropin levels. ( 7536445 )
1994
26
Superior vena cava syndrome due to a substernal nontoxic goiter. ( 8004873 )
1994
27
Determinants of outcome in sporadic nontoxic goiter. ( 1284332 )
1992
28
Thyroid hormone suppressive therapy of sporadic nontoxic goiter. ( 1422239 )
1992
29
Hypervascularity of nontoxic goiter as shown by color-coded Doppler sonography. ( 1772472 )
1991
30
Bone Gla protein and sex hormone-binding globulin in nontoxic goiter: parameters for metabolic status at the tissue level. ( 2294139 )
1990
31
Interrelationships between age, thyroid volume, thyroid nodularity, and thyroid function in patients with sporadic nontoxic goiter. ( 2239979 )
1990
32
Transforming growth factor beta regulates thyroid growth. Role in the pathogenesis of nontoxic goiter. ( 2921318 )
1989
33
Pathogenetic relevance of HLA class II expressing thyroid follicular cells in nontoxic Goiter and in Graves' disease. ( 3130398 )
1988
34
Increased thyroidal T4/T3 ratio in nodular and paranodular tissues of nontoxic goiter following suppressive treatment with thyroid hormones. ( 3570153 )
1987
35
Serum thyroglobulin concentration in nontoxic goiter and response to surgery with special reference to risk of goiter relapse. ( 3092474 )
1986
36
Triiodothyronine suppression of diffuse nontoxic goiter. ( 6470438 )
1984
37
Seasonal variation of stable intrathyroidal iodine in nontoxic goiter disclosed by x-ray fluorescence. ( 7096913 )
1982
38
Serum thyroglobulin in patients undergoing subtotal thyroidectomy for toxic and nontoxic goiter. ( 7108151 )
1982
39
Thyroid blood flow rate in man. Electromagnetic flowmetry during operation in euthyroid normal gland, nontoxic goiter, and hyperthyroidism. ( 6459360 )
1981
40
Endemic and sporadic nontoxic goiter. ( 7033981 )
1981
41
Thyroid uptake on bone scan in a large, multinodular, nontoxic goiter with calcific degeneration. ( 7438651 )
1980
42
Thyroglobulin and calcitonin in patients with nontoxic goiter. ( 702754 )
1978
43
Different sensitivity of 131I uptake and TRH test during thyroxine treatment of nontoxic goiter. ( 122399 )
1978
44
Increased serum thyroglobulin levels in patients with nontoxic goiter. ( 755050 )
1978
45
Nontoxic goiter-diffuse or nodular. ( 1174255 )
1975
46
Deficient cytochrome b5 reductase activity in nontoxic goiter with iodide organification defect. ( 1165726 )
1975
47
Serum triiodothyronine in simple nontoxic goiter in Sicily. ( 1213666 )
1975
48
Suppressive therapy of nontoxic goiter. ( 4432862 )
1974
49
Thyrotropin response to synthetic thyrotropin-releasing hormone in normal subjects and in patients with nontoxic goiter. ( 4115461 )
1972
50
TSH production rate in nontoxic goiter. ( 5577165 )
1971

Variations for Nontoxic Goiter

Expression for Nontoxic Goiter

Search GEO for disease gene expression data for Nontoxic Goiter.

Pathways for Nontoxic Goiter

GO Terms for Nontoxic Goiter

Cellular components related to Nontoxic Goiter according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.43 BGLAP CALCA FASLG SERPINA7 SHBG TG
2 extracellular space GO:0005615 9.1 BGLAP CALCA FASLG SERPINA7 TG TPO

Biological processes related to Nontoxic Goiter according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.5 CALCA FASLG TG
2 cell-cell signaling GO:0007267 9.33 CALCA FASLG TSHR
3 adenylate cyclase-activating G-protein coupled receptor signaling pathway GO:0007189 9.26 CALCA TSHR
4 activation of adenylate cyclase activity GO:0007190 8.96 CALCA TSHR
5 hormone biosynthetic process GO:0042446 8.62 TG TPO

Sources for Nontoxic Goiter

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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