MCID: NNT010
MIFTS: 38

Nontoxic Goiter

Categories: Endocrine diseases
Data Licensing
For inquiries, contact:

Aliases & Classifications for Nontoxic Goiter

MalaCards integrated aliases for Nontoxic Goiter:

Name: Nontoxic Goiter 11 53 14 71
Retrosternal Thyroid Struma 33
Thyroid Gland Hypertrophy 33
Thyroid Gland Hyperplasia 33
Swelling of Thyroid Gland 33
Nodule-Thyroid, Non Tox 11
Non-Toxic Simple Goitre 11
Substernal Thyroid Mass 33
Sporadic Nodular Struma 33
Nontoxic Nodular Goitre 33
Enlarged Thyroid Gland 33
Hypertrophic Thyroid 33
Intrathoracic Goitre 33
Thyroid Hypertrophy 33
Thyroid Hyperplasia 33
Retrosternal Goitre 33
Hyperplastic Goitre 33
Substernal Thyroid 33
Goiter, Non-Toxic 11
Goitre, Non-Toxic 11
Substernal Goitre 33
Struma of Thyroid 33
Non-Toxic Goitre 11
Plunging Goitre 33
Nodular Goitre 33
Nodular Struma 33
Form of Goitre 33
Goitre Struma 33
Thyromegaly 33
Goitre Nos 33

Classifications:



External Ids:

Disease Ontology 11 DOID:13195
NCIt 49 C35271
SNOMED-CT 68 267369002
ICD10 31 E04.8 E04.9
UMLS 71 C0221777

Summaries for Nontoxic Goiter

MalaCards based summary: Nontoxic Goiter, also known as retrosternal thyroid struma, is related to goiter, multinodular 1, with or without sertoli-leydig cell tumors and hypothyroidism, congenital, nongoitrous, 2. An important gene associated with Nontoxic Goiter is TG (Thyroglobulin), and among its related pathways/superpathways are G alpha (s) signalling events and Development_Hedgehog and PTH signaling pathways in bone and cartilage development. The drugs Methimazole and Hormones have been mentioned in the context of this disorder. Affiliated tissues include thyroid, pituitary and bone, and related phenotype is skeleton.

Related Diseases for Nontoxic Goiter

Diseases related to Nontoxic Goiter via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 238)
# Related Disease Score Top Affiliating Genes
1 goiter, multinodular 1, with or without sertoli-leydig cell tumors 32.3 TPO TG
2 hypothyroidism, congenital, nongoitrous, 2 30.9 TSHR TG
3 congenital hypothyroidism 30.5 TSHR TPO TG SHBG SERPINA7 PTH
4 papillary thyroid microcarcinoma 30.2 TG CALCA
5 goiter 30.1 TSHR TPO TG SHBG SERPINA7 CALCA
6 horner's syndrome 30.0 TG CALCA
7 adenoma 30.0 TSHR TG PTH
8 hypothyroidism, congenital, nongoitrous, 1 29.9 TSHR TG PTH
9 thyroid cancer, nonmedullary, 2 29.8 TSHR TG CALCA
10 turner syndrome 29.8 TPO TG SHBG SERPINA7
11 fetal adenoma 29.8 TG CALCA
12 thyroid lymphoma 29.7 TPO TG CALCA
13 subacute thyroiditis 29.7 TSHR TPO TG SERPINA7
14 parathyroid adenoma 29.6 TG PTH CALCA
15 myxedema 29.6 TSHR TPO TG SERPINA7
16 thyroid crisis 29.6 TSHR TPO TG SERPINA7
17 hypoparathyroidism 29.6 TPO PTH CALCA BGLAP
18 thyroid dyshormonogenesis 2a 29.6 TSHR TPO TG CALCA
19 thyroid gland follicular carcinoma 29.5 TSHR TPO TG CALCA
20 papillary carcinoma 29.5 TSHR TPO TG CALCA
21 substernal goiter 29.5 TG PTH CALCA
22 hyperparathyroidism 29.5 PTH CALCA BGLAP
23 nodular goiter 29.5 TSHR TPO TG PTH CALCA
24 graves' disease 29.5 TSHR TPO TG SERPINA7 ICOSLG FASLG
25 thyroid gland anaplastic carcinoma 29.5 TSHR TPO TG CALCA
26 postsurgical hypothyroidism 29.5 TSHR TPO TG PTH
27 follicular adenoma 29.4 TSHR TPO TG CALCA
28 thyroid gland medullary carcinoma 29.4 TG PTH CALCA
29 multinodular goiter 29.4 TSHR TPO TG PTH CALCA
30 primary hyperparathyroidism 29.4 PTH CALCA BGLAP
31 hypothyroidism 29.4 TSHR TPO TG SHBG SERPINA7 CALCA
32 acute thyroiditis 29.3 TPO TG SERPINA7 CALCA
33 autoimmune disease 29.3 TSHR TPO TG ICOSLG FASLG
34 multiple endocrine neoplasia, type iia 29.2 PTH CALCA
35 thyroiditis 29.2 TSHR TPO TG SERPINA7 FASLG CALCA
36 multiple endocrine neoplasia 29.1 TG PTH CALCA
37 graves disease 1 29.1 TSHR TPO TG SHBG SERPINA7 PTH
38 thyroid gland cancer 28.9 TSHR TPO TG PTH CALCA
39 hashimoto thyroiditis 28.8 TSHR TPO TG SERPINA7 ICOSLG FASLG
40 type 2 diabetes mellitus 28.8 TPO SHBG PTH ICOSLG BGLAP
41 endemic goiter 28.8 TSHR TPO TG SERPINA7 PTH CALCA
42 hyperthyroidism 28.7 TSHR TPO TG SHBG SERPINA7 PTH
43 plummer's disease 28.5 TSHR TPO TG SHBG SERPINA7 PTH
44 thyroid gland disease 27.7 TSHR TPO TG SHBG SERPINA7 PTH
45 hyperthyroidism, nonautoimmune 11.5
46 permanent congenital hypothyroidism 11.3
47 hypothyroidism, congenital, nongoitrous, 3 10.4
48 mechanical strabismus 10.2 TPO TG
49 hypothyroidism, congenital, nongoitrous, 4 10.2 TPO TG
50 neonatal thyrotoxicosis 10.2 TSHR TG

Graphical network of the top 20 diseases related to Nontoxic Goiter:



Diseases related to Nontoxic Goiter

Symptoms & Phenotypes for Nontoxic Goiter

MGI Mouse Phenotypes related to Nontoxic Goiter:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 skeleton MP:0005390 9.17 BGLAP CALCA FASLG PTH TG TPO

Drugs & Therapeutics for Nontoxic Goiter

Drugs for Nontoxic Goiter (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methimazole Approved Phase 4 60-56-0 1349907
2 Hormones Phase 4
3 Hormone Antagonists Phase 4
4 Antithyroid Agents Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Influence of Continuous Treatment With Antithyroid Drugs on the Effect of Radioiodine in Patients With Hyperthyroidism Completed NCT00150137 Phase 4 Methimazole
2 The Influence of Continuous Block-replacement Therapy on the Effect of Radioiodine in Patients With Hyperthyroidism Completed NCT00150124 Phase 4 MTZ+LT4;Methimazole
3 ThyrOp: Individual Subclinical Hypothyroidism After Hemithyroidectomy for Benign Nontoxic Goiter - Focus on Weight Gain and Mitochondrial Dysfunction Unknown status NCT01358136
4 The Effect of Healthy Eating Index on Maternal Thyroid Volume in Hyperemesis Gravidarum Completed NCT04528186

Search NIH Clinical Center for Nontoxic Goiter

Genetic Tests for Nontoxic Goiter

Anatomical Context for Nontoxic Goiter

Organs/tissues related to Nontoxic Goiter:

MalaCards : Thyroid, Pituitary, Bone, Trachea, Thymus, Breast, Fetal Thyroid

Publications for Nontoxic Goiter

Articles related to Nontoxic Goiter:

(show top 50) (show all 1859)
# Title Authors PMID Year
1
Increased major histocompatibility complex (MHC) expression in nontoxic goiters is associated with iodide depletion, enhanced ability of the follicular thyroglobulin to increase MHC gene expression, and thyroid autoantibodies. 53 62
10690902 2000
2
[Apoptosis in Hashimoto's thyroiditis]. 53 62
9396343 1997
3
Thyrotropin receptor antibodies and Graves' disease, a side-effect of 131I treatment in patients with nontoxic goiter. 53 62
9284721 1997
4
Long-term observation of serum thyroglobulin after resection of nontoxic goiter and relation to ultrasonographically demonstrated relapse. 53 62
8661844 1996
5
Bispecific thyroglobulin and thyroperoxidase autoantibodies in patients with various thyroid and autoimmune diseases. 53 62
7962336 1994
6
Epitopes on thyroglobulin: a study of patients with thyroid disease. 53 62
7528064 1994
7
Radioiodine uptake as a function of stored iodine and thyroglobulin in thyroid follicles: in vitro quantitative imaging approach with secondary ion mass spectrometry (SIMS) microscopy in human nontoxic goiter. 53 62
7920005 1994
8
Bone Gla protein and sex hormone-binding globulin in nontoxic goiter: parameters for metabolic status at the tissue level. 53 62
2294139 1990
9
Impact of direct laryngoscopy vs. videolaryngoscopy on signal quality of recurrent laryngeal nerve monitoring in thyroid surgery: a randomised parallel group trial. 62
36166515 2023
10
Tension-free thyroidectomy (TFT): initial report. 62
35913529 2022
11
Chronic Myopathy as the Initial Manifestation of Thyrotoxicosis: A Report of 2 Cases. 62
36409340 2022
12
Transcriptome-metabolome-wide association study (TMWAS) in rats revealed a potential carcinogenic effect of DEHP in thyroid associated with eicosanoids. 62
35810816 2022
13
Depth of mediastinal extension can predict sternotomy need for substernal thyroid goiters. 62
36031445 2022
14
Long term outcome after toxic nodular goitre. 62
36316779 2022
15
Clinical usefulness of thyroid ultrasonography in patients with primary hypothyroidism. 62
36428205 2022
16
Loss of thyroid gland circadian PER2 rhythmicity in aged mice and its potential association with thyroid cancer development. 62
36284088 2022
17
Transcervical and robotic-assisted thoracoscopic resection of a substernal goiter. 62
36207056 2022
18
Morbidity Associated With Surgical Removal of Substernal Thyroid Goiters. 62
35504153 2022
19
Hyperthyroid cats and their kidneys: a literature review. 62
35711100 2022
20
HLA Class I Expression Changes in Different Types of Cultured Parathyroid Cells. 62
30995898 2022
21
Using the Random Forest Algorithm to Detect the Activity of Graves Orbitopathy. 62
35996213 2022
22
Case Report: Disseminated Burkholderia pseudomallei with Acute Suppurative Thyroiditis and Abscess Formation. 62
35914690 2022
23
New-Onset Graves' Disease in the Background of Hashimoto's Thyroiditis: Spectrums of the Same Disease With Changing Autoantibodies. 62
36158389 2022
24
Thyroidectomy via unilateral axillo-breast approach (UABA) with gas insufflation: prospective multicentre European study. 62
35799351 2022
25
Autoimmune thyroiditis a fibrous variant of Hashimoto's thyroiditis: A rare case. 62
35860079 2022
26
Out of sight, out of mind: retrosternal goitre as a rare cause of breathlessness. 62
35938758 2022
27
Cervicotomy using a hemi-clamshell approach for a rare enlarged substernal goitre. 62
35237808 2022
28
Ischemic stroke: a rare complication of a large multinodular goiter. 62
36103594 2022
29
Estimating short and longer-term exposure of domestic cats to dietary iodine fluctuation. 62
35643927 2022
30
Graves' disease in an adolescent presenting with increased intracranial pressure and bilateral papilledema. 62
35466085 2022
31
Use of Lithium in Hyperthyroidism Secondary to Graves' Disease: A Case Report. 62
35477705 2022
32
Predictors of Malignancy in Thyroid Nodules. 62
35383753 2022
33
Minimally invasive combined approach robotic thymectomy and transcervical total thyroidectomy. 62
35459655 2022
34
Prediction factors for the risk of diffuse non-toxic goiter development in type 2 diabetic patients. 62
35436270 2022
35
Thyroid Disease and Hepatocellular Carcinoma Survival: A Danish Nationwide Cohort Study. 62
35528746 2022
36
TSHRV656F Activating Variant of the Thyroid Stimulating Hormone Receptor Gene in Neonatal Onset Hyperthyroidism: A Case Review 62
33443352 2022
37
A Case of Severe Dilated Cardiomyopathy and Hyperthyroidism. 62
35415035 2022
38
Retro-sternal Goitre: an Overview. 62
35462655 2022
39
Retrosternal Goitre: Anatomical Aspects and Technical Notes. 62
35334525 2022
40
Presentation and Management Outcomes of Goitres at a District Hospital in Abuja, North Central Nigeria: A 15-Year-Review. 62
35278055 2022
41
Giant retrosternal goitre causing lung atelectasis. 62
36059170 2022
42
Comparison of Modified Rose Method of Thyroid Palpation Versus Other Methods for the Detection of Retrosternal and Nodular Goitre. 62
35800594 2022
43
New insights into thyroid dysfunction in patients with inactivating parathyroid hormone/parathyroid hormone-related protein signalling disorder (the hormonal and ultrasound aspects): One-centre preliminary results. 62
36213284 2022
44
Cellular and molecular basis of thyroid autoimmunity. 62
34981746 2022
45
The utility of 18F-fluorocholine PET/CT in the imaging of parathyroid adenomas. 62
35119087 2022
46
Serological Characteristics, Etiological Analysis, and Treatment Prognosis of Children with Congenital Hypothyroidism. 62
36204333 2022
47
Subacute thyroiditis during early pregnancy: a case report and literature review. 62
34996368 2022
48
Non-Toxic Multinodular Goiter: From Etiopathogenesis to Treatment. 62
35515961 2022
49
Is hemithyroidectomy sufficient in unilateral benign nodular goitre? 62
32969625 2021
50
Laryngeal varices: an atypical cause of globus. 62
34969797 2021

Variations for Nontoxic Goiter

Expression for Nontoxic Goiter

Search GEO for disease gene expression data for Nontoxic Goiter.

Pathways for Nontoxic Goiter

GO Terms for Nontoxic Goiter

Cellular components related to Nontoxic Goiter according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.8 TG SHBG SERPINA7 PTH FASLG CALCA
2 extracellular space GO:0005615 9.47 TPO TG SERPINA7 PTH FASLG CALCA

Biological processes related to Nontoxic Goiter according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 9.8 TSHR PTH CALCA
2 response to vitamin D GO:0033280 9.56 PTH BGLAP
3 thyroid hormone generation GO:0006590 9.46 TPO TG
4 hormone biosynthetic process GO:0042446 9.26 TPO TG
5 cell-cell signaling GO:0007267 9.17 TSHR PTH FASLG CALCA

Molecular functions related to Nontoxic Goiter according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.1 TG PTH CALCA

Sources for Nontoxic Goiter

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....