MCID: NNT010
MIFTS: 32

Nontoxic Goiter

Categories: Endocrine diseases

Aliases & Classifications for Nontoxic Goiter

MalaCards integrated aliases for Nontoxic Goiter:

Name: Nontoxic Goiter 12 54 15 70
Nodule-Thyroid, Non Tox 12
Non-Toxic Simple Goitre 12
Goiter, Non-Toxic 12
Goitre, Non-Toxic 12
Non-Toxic Goitre 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13195
NCIt 50 C35271
SNOMED-CT 67 267369002
ICD10 32 E04.8 E04.9
UMLS 70 C0221777

Summaries for Nontoxic Goiter

MalaCards based summary : Nontoxic Goiter, also known as nodule-thyroid, non tox, is related to goiter, multinodular 1, with or without sertoli-leydig cell tumors and nodular goiter. An important gene associated with Nontoxic Goiter is TG (Thyroglobulin), and among its related pathways/superpathways are Aldosterone synthesis and secretion and Allograft rejection. Affiliated tissues include thyroid, bone and breast, and related phenotype is endocrine/exocrine gland.

Related Diseases for Nontoxic Goiter

Diseases related to Nontoxic Goiter via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 147)
# Related Disease Score Top Affiliating Genes
1 goiter, multinodular 1, with or without sertoli-leydig cell tumors 32.3 TPO TG
2 nodular goiter 30.2 TSHR TPO TG CALCA
3 adenoma 30.1 TSHR TG PTH
4 goiter 30.1 TSHR TPO TG SERPINA7 CALCA BGLAP
5 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 30.1 TSHR TPO TG
6 postsurgical hypothyroidism 30.0 TPO TG PTH
7 thyroid carcinoma 29.8 TSHR TPO TG CALCA
8 hypoparathyroidism 29.8 TPO PTH CALCA BGLAP
9 substernal goiter 29.8 TG PTH CALCA
10 hyperparathyroidism 29.7 PTH CALCA BGLAP
11 breast disease 29.7 SHBG ICOSLG FASLG
12 bone resorption disease 29.7 PTH CALCA BGLAP
13 multinodular goiter 29.6 TSHR TPO TG PTH CALCA
14 papillary carcinoma 29.6 TSHR TPO TG CALCA
15 myxedema 29.4 TSHR TPO TG SERPINA7
16 autoimmune disease 29.4 TSHR TPO TG ICOSLG FASLG
17 graves' disease 29.2 TSHR TPO TG SERPINA7 ICOSLG FASLG
18 subacute thyroiditis 29.2 TSHR TPO TG SHBG SERPINA7
19 hypothyroidism 29.0 TSHR TPO TG SHBG SERPINA7 CALCA
20 thyroiditis 28.9 TSHR TPO TG SERPINA7 FASLG CALCA
21 endemic goiter 28.7 TSHR TPO TG SERPINA7 PTH CALCA
22 plummer's disease 28.7 TSHR TPO TG SHBG SERPINA7 PTH
23 hashimoto thyroiditis 28.6 TSHR TPO TG SERPINA7 FASLG CALCA
24 hyperthyroidism 28.6 TSHR TPO TG SHBG SERPINA7 PTH
25 graves disease 1 28.2 TSHR TPO TG SHBG SERPINA7 PTH
26 thyroid gland disease 27.8 TSHR TPO TG SHBG SERPINA7 PTH
27 mechanical strabismus 10.3 TPO TG
28 aspirin allergy 10.3 TPO TG
29 transient congenital hypothyroidism 10.2 TSHR TPO
30 type 1 diabetes mellitus 20 10.2 TPO TG
31 athyreosis 10.2 TSHR TG
32 hypotropia 10.2 TSHR TPO
33 adrenal cortical hypofunction 10.2 TPO TG
34 pernicious anemia 10.2 TPO TG
35 struma ovarii 10.2 TSHR TG
36 benign struma ovarii 10.2 TSHR TG
37 orbital disease 10.2 TSHR TG
38 clear cell adenoma 10.2 TG PTH
39 hypothyroidism, congenital, nongoitrous, 2 10.2 TSHR TG
40 thyroid cancer, nonmedullary, 1 10.2
41 tall cell variant papillary carcinoma 10.1 TG PTH
42 thyroid gland mucoepidermoid carcinoma 10.1 TG CALCA
43 anal spasm 10.1 TG PTH
44 spindle epithelial tumor with thymus-like differentiation tumor 10.1 TG CALCA
45 isthmus cancer 10.1 TG CALCA
46 atypical follicular adenoma 10.1 TG CALCA
47 thyroid sarcoma 10.1 TG CALCA
48 carotid body cancer 10.1 TG CALCA
49 vitamin d-dependent rickets 10.1 PTH BGLAP
50 adrenal cortex disease 10.1 TPO TG

Graphical network of the top 20 diseases related to Nontoxic Goiter:



Diseases related to Nontoxic Goiter

Symptoms & Phenotypes for Nontoxic Goiter

MGI Mouse Phenotypes related to Nontoxic Goiter:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.1 BGLAP FASLG PTH TG TPO TSHR

Drugs & Therapeutics for Nontoxic Goiter

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 ThyrOp: Individual Subclinical Hypothyroidism After Hemithyroidectomy for Benign Nontoxic Goiter - Focus on Weight Gain and Mitochondrial Dysfunction Unknown status NCT01358136

Search NIH Clinical Center for Nontoxic Goiter

Genetic Tests for Nontoxic Goiter

Anatomical Context for Nontoxic Goiter

MalaCards organs/tissues related to Nontoxic Goiter:

40
Thyroid, Bone, Breast, Thymus, Adrenal Gland, Cortex, Uterus

Publications for Nontoxic Goiter

Articles related to Nontoxic Goiter:

(show top 50) (show all 248)
# Title Authors PMID Year
1
Increased major histocompatibility complex (MHC) expression in nontoxic goiters is associated with iodide depletion, enhanced ability of the follicular thyroglobulin to increase MHC gene expression, and thyroid autoantibodies. 61 54
10690902 2000
2
[Apoptosis in Hashimoto's thyroiditis]. 61 54
9396343 1997
3
Thyrotropin receptor antibodies and Graves' disease, a side-effect of 131I treatment in patients with nontoxic goiter. 61 54
9284721 1997
4
Long-term observation of serum thyroglobulin after resection of nontoxic goiter and relation to ultrasonographically demonstrated relapse. 61 54
8661844 1996
5
Bispecific thyroglobulin and thyroperoxidase autoantibodies in patients with various thyroid and autoimmune diseases. 61 54
7962336 1994
6
Radioiodine uptake as a function of stored iodine and thyroglobulin in thyroid follicles: in vitro quantitative imaging approach with secondary ion mass spectrometry (SIMS) microscopy in human nontoxic goiter. 54 61
7920005 1994
7
Epitopes on thyroglobulin: a study of patients with thyroid disease. 61 54
7528064 1994
8
Bone Gla protein and sex hormone-binding globulin in nontoxic goiter: parameters for metabolic status at the tissue level. 54 61
2294139 1990
9
Association between various thyroid gland diseases, TSH values and thyroid cancer: a case-control study. 61
32518973 2020
10
When Alice Took Sertraline: A Case of Sertraline-Induced Alice in Wonderland Syndrome. 61
33005552 2020
11
The artist's wife with a simple nontoxic goiter. 61
32140859 2020
12
Elevated serum concentrations of IGF-1 and IGF-1R in patients with thyroid cancers. 61
31132076 2020
13
Benign Thyroid Diseases: Are There Gender-Specific Differences for Diagnosis and Treatment of Nontoxic Thyroid Nodules? Results from a 4-Year Retrospective Analysis of an Endocrine Tumor Board. 61
32110654 2020
14
The Influence of Diffuse Nontoxic Goiter on the State of Protective Mechanisms of the Oral Cavity in Children. 61
32341696 2020
15
A two kilograms euthyroid goiter in Singida Regional Referral Hospital, Central Tanzania: Case report. 61
33227691 2020
16
Concurrence of Myasthenia Gravis and Thyroid Disorders: A Retrospective Database Study. 61
33442150 2019
17
[Diagnoses of thyroid disorders in ENT and general practices in Germany between 2008 and 2016]. 61
30298217 2018
18
Alteration in the serum concentrations of FGF19, FGFR4 and ╬▓Klotho in patients with thyroid cancer. 61
29438906 2018
19
Nontoxic Goiter (NTG) and Radioiodine: What Do Patients Think About It? Quality of Life in Patients with NTG Before and After 131-I Therapy. 61
29713309 2018
20
Increased Cardiovascular Mortality and Morbidity in Patients Treated for Toxic Nodular Goiter Compared to Graves' Disease and Nontoxic Goiter. 61
28471268 2017
21
Elevated Concentrations of SERPINE2/Protease Nexin-1 and Secretory Leukocyte Protease Inhibitor in the Serum of Patients with Papillary Thyroid Cancer. 61
28255192 2017
22
Radioiodine Therapy Does Not Change the Atherosclerotic Burden of the Carotid Arteries. 61
27117943 2016
23
Graves' disease in a mediastinal mass presenting after total thyroidectomy for nontoxic multinodular goiter: a case report. 61
27029843 2016
24
Total Thyroidectomy versus Bilateral Subtotal Thyroidectomy for Bilateral Multinodular Nontoxic Goiter: A Meta-Analysis. 61
27256349 2016
25
[The problem of iodine deficiency and its solution in the republic of Belarus]. 61
29412546 2016
26
[IMPACT ON DIFFERENTIATED THERAPY OF SOMATIC AND SEXUAL DEVELOPMENT OF ADOLESCENTS WITH DIFFUSE NONTOXIC GOITER]. 61
27089722 2015
27
Quality of life in patients with benign nontoxic goiter: impact of disease and treatment response, and comparison with the general population. 61
25602312 2015
28
[Imbalance of microelements and vitamins in adolescents with diffuse nontoxic goiter and biliary dyskinesia]. 61
25528853 2014
29
Body weight changes in a large cohort of patients subjected to thyroidectomy for a wide spectrum of thyroid diseases. 61
24936565 2014
30
The thyroid-related quality of life measure ThyPRO has good responsiveness and ability to detect relevant treatment effects. 61
25004246 2014
31
[Distribution iodine deficiency diseases in coastal areas depending on geochemical conditions]. 61
25831939 2014
32
Increased risk of long-term sickness absence, lower rate of return to work, and higher risk of unemployment and disability pensioning for thyroid patients: a Danish register-based cohort study. 61
24937367 2014
33
Decreased birth weight, length, and head circumference in children born by women years after treatment for hyperthyroidism. 61
24878049 2014
34
Detection of heterozygous c.1708C>T and c.1978C>G thyroid peroxidase (TPO) mutations in Iraqi patients with toxic and nontoxic goiter. 61
24482635 2014
35
Lessons learned from the first 50 thyroidectomies with Harmonic Focus Curved Shears - technical note. 61
27057249 2014
36
Micronucleus frequency among Iraqi thyroid disorder patients. 61
24829552 2014
37
A cross-sectional study of subclinical and clinical thyroid disorders in women with microscopic colitis compared to controls. 61
24164462 2013
38
Incidental thyroid cancer in toxic and nontoxic goiter: Is TSH associated with malignanCy rate? Results of a meta-analysis. 61
23186976 2013
39
Overview of thyroid physiology: an essential for understanding familial euthyroid multinodular goiter. 61
23882995 2013
40
Incidental cancer in patients surgically treated for benign thyroid disease. Our experience at a single institution. 61
23463928 2013
41
[Application of herbal medicine alba in treatment of patients with the pathology of thyroid]. 61
23786024 2012
42
Management of an unusual presentation of Ascher syndrome. 61
23172481 2012
43
Effects of levothyroxine on bone mineral density, muscle force, and bone turnover markers: a cohort study. 61
22977269 2012
44
Prestimulation with recombinant human thyrotropin (rhTSH) improves the long-term outcome of radioiodine therapy for multinodular nontoxic goiter. 61
22577172 2012
45
[Peculiarities of thyroid pathology in the childhood]. 61
23534272 2012
46
The metabolic syndrome in thyroid disease: A report from Nigeria. 61
22629511 2012
47
Relationship between metabolic syndrome and multinodular non-toxic goiter in an inpatient population from a geographic area with moderate iodine deficiency. 61
21737999 2012
48
[Peculiarities of formation, clinical presentations and therapy of diffuse nontoxic goiter of children]. 61
23356134 2012
49
[Peculiar features of the clinical and metabolic status and its variations under the influence of rehabilitative treatment in the children with obesity and diffuse non-toxic goiter]. 61
22693739 2012
50
Patients with autoimmune thyroiditis. Prevalence of benign lymphadenopathy. 61
23042429 2012

Variations for Nontoxic Goiter

Expression for Nontoxic Goiter

Search GEO for disease gene expression data for Nontoxic Goiter.

Pathways for Nontoxic Goiter

GO Terms for Nontoxic Goiter

Cellular components related to Nontoxic Goiter according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.5 TG SHBG SERPINA7 PTH FASLG CALCA
2 extracellular space GO:0005615 9.17 TPO TG SERPINA7 PTH FASLG CALCA

Biological processes related to Nontoxic Goiter according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 activation of adenylate cyclase activity GO:0007190 9.37 TSHR CALCA
2 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 9.33 TSHR PTH CALCA
3 response to vitamin D GO:0033280 9.32 PTH BGLAP
4 thyroid hormone generation GO:0006590 9.26 TPO TG
5 hormone biosynthetic process GO:0042446 8.96 TPO TG
6 cell-cell signaling GO:0007267 8.92 TSHR PTH FASLG CALCA

Molecular functions related to Nontoxic Goiter according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.8 TG PTH CALCA

Sources for Nontoxic Goiter

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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