MCID: NNT049
MIFTS: 46

Nontuberculous Mycobacterial Lung Disease

Categories: Infectious diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Nontuberculous Mycobacterial Lung Disease

MalaCards integrated aliases for Nontuberculous Mycobacterial Lung Disease:

Name: Nontuberculous Mycobacterial Lung Disease 54
Pulmonary Non-Tuberculous Mycobacterial Infection 54 60
Non-Tuberculous Mycobacterial Lung Disease 54 60

Characteristics:

Orphanet epidemiological data:

60
pulmonary non-tuberculous mycobacterial infection
Inheritance: Not applicable; Age of onset: All ages;

Classifications:



External Ids:

ICD10 via Orphanet 35 A31.0
Orphanet 60 ORPHA411703

Summaries for Nontuberculous Mycobacterial Lung Disease

NIH Rare Diseases : 54 Nontuberculous mycobacterial (NTM) lung disease is an infectious condition caused by certain types of mycobacteria. Some people with NTM lung disease have no signs or symptoms, while others experience a severe cough, hemoptysis (coughing up blood), shortness of breath, fatigue, fever, night sweats and/or weightloss. Mycobacteria are found naturally in soil and water. Most people who are exposed to these bacteria do not become sick. However, people who have a weakened immune system or other health conditions (i.e. chronic obstructive pulmonary disease, bronchiectasis, pneumoconiosis, cystic fibrosis, and previous tuberculosis) have an elevated risk of developing NTM lung disease. The condition is generally treated with a combination of antibiotics which is often continued until certain tests have been negative for 12 months. In some cases, surgery may be recommended if lung tissue is damaged.

MalaCards based summary : Nontuberculous Mycobacterial Lung Disease, also known as pulmonary non-tuberculous mycobacterial infection, is related to lung disease and mycobacterium abscessus. An important gene associated with Nontuberculous Mycobacterial Lung Disease is TLR2 (Toll Like Receptor 2), and among its related pathways/superpathways are Allograft rejection and Th17 cell differentiation. The drugs Amikacin and Nitric Oxide have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and endothelial, and related phenotypes are hematopoietic system and immune system

Related Diseases for Nontuberculous Mycobacterial Lung Disease

Diseases related to Nontuberculous Mycobacterial Lung Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 133)
# Related Disease Score Top Affiliating Genes
1 lung disease 31.8 CFTR TLR2 TNF
2 mycobacterium abscessus 30.7 CFTR TLR2 TNF
3 pulmonary tuberculosis 30.3 HLA-DRB1 SLC11A1 TLR2 TNF
4 aspergillosis 30.3 CFTR TLR2 TNF
5 rheumatoid arthritis 29.8 HLA-B HLA-DRB1 SLC11A1 TLR2 TNF
6 phenytoin or carbamazepine toxicity 10.3 HLA-A HLA-B
7 bronchiectasis 10.3
8 rheumatoid factor-negative juvenile idiopathic arthritis 10.3 HLA-DRB1 SLC11A1
9 atrial tachyarrhythmia with short pr interval 10.3 HLA-A HLA-B
10 htlv-1 associated myelopathy/tropical spastic paraparesis 10.3 HLA-A HLA-B
11 type 1 diabetes mellitus 12 10.3 HLA-DRB1 SLC11A1
12 tularemia 10.3 SLC11A1 TLR2
13 anterior uveitis 10.3 HLA-A HLA-B
14 chronic pyelonephritis 10.3 HLA-A HLA-B
15 trench fever 10.3 TLR2 TNF
16 idiopathic inflammatory myopathy 10.2 HLA-B HLA-DRB1
17 human herpesvirus 8 10.2 HLA-A HLA-B
18 lung cancer 10.2
19 arthritis 10.2
20 iron overload in africa 10.2 HLA-A SLC11A1
21 haemophilus influenzae 10.2 TLR2 TNF
22 congenital cytomegalovirus 10.2 TLR2 TNF
23 hemorrhagic fever 10.2 HLA-DRB1 TNF
24 drug reaction with eosinophilia and systemic symptoms 10.2 HLA-B TNF
25 penicilliosis 10.2 TLR2 TNF
26 cardiac sarcoidosis 10.2 IL12B TNF
27 periapical periodontitis 10.2 TLR2 TNF
28 microscopic polyangiitis 10.2 HLA-DRB1 TNF
29 beryllium disease 10.2 HLA-DRB1 TNF
30 chronic beryllium disease 10.2 HLA-DRB1 TNF
31 spondylarthropathy 10.2 TLR2 TNF
32 pure red-cell aplasia 10.1 HLA-A HLA-DRB1
33 actinic prurigo 10.1 HLA-DRB1 TNF
34 arthrogryposis, distal, type 9 10.1
35 carcinoid syndrome 10.1
36 periodontosis 10.1 HLA-A TNF
37 pulmonary hypertension, primary, 1 10.1
38 pulmonary hypertension, chronic thromboembolic, without deep vein thrombosis 10.1
39 pulmonary hypertension 10.1
40 chronic thromboembolic pulmonary hypertension 10.1
41 microscopic colitis 10.1 HLA-DRB1 TNF
42 leprosy 3 10.1 SLC11A1 TLR2 TNF
43 sympathetic ophthalmia 10.1 HLA-DRB1 TNF
44 testicular disease 10.1 SLC11A1 TLR2 TNF
45 primary bacterial infectious disease 10.1 SLC11A1 TLR2 TNF
46 postherpetic neuralgia 10.1 HLA-A HLA-B HLA-DRB1
47 cutaneous leishmaniasis 10.1 SLC11A1 TLR2 TNF
48 visceral leishmaniasis 10.1 SLC11A1 TLR2 TNF
49 pars planitis 10.1 HLA-A HLA-B HLA-DRB1
50 typhoid fever 10.1 CFTR SLC11A1 TNF

Graphical network of the top 20 diseases related to Nontuberculous Mycobacterial Lung Disease:



Diseases related to Nontuberculous Mycobacterial Lung Disease

Symptoms & Phenotypes for Nontuberculous Mycobacterial Lung Disease

MGI Mouse Phenotypes related to Nontuberculous Mycobacterial Lung Disease:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.92 ADIPOQ CFTR FBN1 IL12B LEP SLC11A1
2 immune system MP:0005387 9.86 ADIPOQ CFTR FBN1 IL12B LEP SLC11A1
3 digestive/alimentary MP:0005381 9.85 CFTR IL12B LEP SLC11A1 TLR2 TNF
4 adipose tissue MP:0005375 9.8 ADIPOQ FBN1 LEP TLR2 TNF
5 neoplasm MP:0002006 9.63 ADIPOQ IL12B LEP SLC11A1 TLR2 TNF
6 respiratory system MP:0005388 9.5 ADIPOQ CFTR FBN1 IL12B LEP TLR2
7 skeleton MP:0005390 9.17 ADIPOQ BMP6 FBN1 IL12B LEP TLR2

Drugs & Therapeutics for Nontuberculous Mycobacterial Lung Disease

Drugs for Nontuberculous Mycobacterial Lung Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amikacin Approved, Investigational, Vet_approved Phase 2 37517-28-5 37768
2
Nitric Oxide Approved Phase 1, Phase 2,Phase 2 10102-43-9 145068
3
Sodium Citrate Approved, Investigational Phase 1, Phase 2 68-04-2
4
Citric Acid Approved, Nutraceutical, Vet_approved Phase 1, Phase 2 77-92-9 311
5 Anti-Bacterial Agents Phase 2
6 Anti-Infective Agents Phase 2,Phase 1
7 Phosphodiesterase Inhibitors Phase 1, Phase 2
8 Citrate Phase 1, Phase 2
9 Phosphodiesterase 5 Inhibitors Phase 1, Phase 2
10 Sildenafil Citrate Phase 1, Phase 2 171599-83-0
11 Vasodilator Agents Phase 1, Phase 2,Phase 2
12 Antioxidants Phase 2
13 Peripheral Nervous System Agents Phase 2
14 Neurotransmitter Agents Phase 2
15 Anti-Asthmatic Agents Phase 2
16 Autonomic Agents Phase 2
17 Free Radical Scavengers Phase 2
18 Bronchodilator Agents Phase 2
19 Respiratory System Agents Phase 2
20 Endothelium-Dependent Relaxing Factors Phase 2
21 Protective Agents Phase 2
22 Antiviral Agents Phase 1
23 Interferon-gamma Phase 1
24 interferons Phase 1
25 Adjuvants, Immunologic Phase 1
26 Interleukin-12 Phase 1
27 Angiogenesis Inhibitors Phase 1
28 Angiogenesis Modulating Agents Phase 1
29 Immunologic Factors Phase 1

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Arikayce for Nontuberculous Mycobacteria Completed NCT01315236 Phase 2 Liposomal amikacin for inhalation (LAI);placebo
2 Sildenafil for PNTM Infection Completed NCT01853540 Phase 1, Phase 2 Sildenafil
3 A Proof of Concept Study of Inhaled Nitric Oxide for Adults With Pulmonary Non-Tuberculous Mycobacterial Infection Enrolling by invitation NCT03748992 Phase 2 gNO
4 Inhaled Amikacin Treatment for Nontuberculous Mycobacterial Lung Disease Withdrawn NCT01528930 Phase 2 Amikacin
5 Adjuvant Cytokine Therapy to Treat Pulmonary Mycobacterium Avium Complex Infection Completed NCT00111397 Phase 1 Interferon Gamma, GM-CSF
6 Interleukin-12 in the Treatment of Severe Nontuberculous Mycobacterial Infections Completed NCT00001911 Phase 1 Interleukin-12
7 Diagnostic Accuracy of Nontuberculous Mycobacterial Lung Disease Based on Chest CT Completed NCT02340897
8 Comparing Expectorated and Induced Sputum and Pharyngeal Swabs for Cultures, AFB Smears, and Cytokines in Pulmonary Nontuberculous Mycobacterial Infection Completed NCT01150721
9 Genetic Disorders of Mucociliary Clearance in Nontuberculous Mycobacterial Lung Disease Completed NCT00368446
10 Study of Nontuberculous Mycobacterial Lung Disease Recruiting NCT00970801
11 Genome-Wide Association Study in Patients With Nontuberculous Mycobacterial Lung Disease Recruiting NCT02832843

Search NIH Clinical Center for Nontuberculous Mycobacterial Lung Disease

Genetic Tests for Nontuberculous Mycobacterial Lung Disease

Anatomical Context for Nontuberculous Mycobacterial Lung Disease

MalaCards organs/tissues related to Nontuberculous Mycobacterial Lung Disease:

42
Lung, Testes, Endothelial, Placenta

Publications for Nontuberculous Mycobacterial Lung Disease

Articles related to Nontuberculous Mycobacterial Lung Disease:

(show top 50) (show all 83)
# Title Authors Year
1
Assessment of 7 trace elements in serum of patients with nontuberculous mycobacterial lung disease. ( 30910213 )
2019
2
Right extrapleural completion pneumonectomy for fibrocavitary nontuberculous mycobacterial lung disease. ( 29445484 )
2018
3
Nontuberculous mycobacterial lung disease in a patient with COPD and bronchiectasis, with radiological signs of lung tumor. ( 29490418 )
2018
4
The outcomes of anatomical lung resection for nontuberculous mycobacterial lung disease. ( 29607168 )
2018
5
Amikacin Inhalation as Salvage Therapy for Refractory Nontuberculous Mycobacterial Lung Disease. ( 29661870 )
2018
6
Elucidating the Pathogenesis of Nontuberculous Mycobacterial Lung Disease: Lesson from the Six Blind Men and the Elephant. ( 29388833 )
2018
7
Nontuberculous mycobacterial lung disease in a high tuberculosis incidence setting in Brazil. ( 29791549 )
2018
8
Development of lung cancer in patients with; nontuberculous mycobacterial lung disease. ( 30598398 )
2018
9
Infection Source and Epidemiology of Nontuberculous Mycobacterial Lung Disease. ( 30302953 )
2018
10
Relative risk of all-cause mortality in patients with nontuberculous mycobacterial lung disease in a US managed care population. ( 30509721 )
2018
11
Assessing Response to Therapy for Nontuberculous Mycobacterial Lung Disease: Quo Vadis? ( 30524407 )
2018
12
A retrospective study of factors associated with treatment decision for nontuberculous mycobacterial lung disease in adults without altered systemic immunity. ( 30547753 )
2018
13
Health Care Utilization and Expenditures Following Diagnosis of Nontuberculous Mycobacterial Lung Disease in the United States. ( 30028225 )
2018
14
Risk factors for the development of chronic pulmonary aspergillosis in patients with nontuberculous mycobacterial lung disease. ( 29190796 )
2017
15
Causative species of nontuberculous mycobacterial lung disease and comparative investigation on clinical features of Mycobacterium abscessus complex disease: A retrospective analysis for two major hospitals in a subtropical region of Japan. ( 29059250 )
2017
16
Characteristics associated with progression in patients with of nontuberculous mycobacterial lung disease : a prospective cohort study. ( 28056937 )
2017
17
A Laboratory-based Analysis of Nontuberculous Mycobacterial Lung Disease in Japan from 2012 to 2013. ( 27788025 )
2017
18
Epidemiology of Nontuberculous Mycobacterial Lung Disease and Tuberculosis, Hawaii, USA. ( 28221128 )
2017
19
Down-Regulation of Serum High-Mobility Group Box 1 Protein in Patients with Pulmonary Tuberculosis and Nontuberculous Mycobacterial Lung Disease. ( 28416955 )
2017
20
Prolonged use of tedizolid in a pulmonary non-tuberculous mycobacterial infection after linezolid-induced toxicity. ( 27999019 )
2017
21
Lung Function Decline According to Clinical Course in Nontuberculous Mycobacterial Lung Disease. ( 27298072 )
2016
22
Regimens for nontuberculous mycobacterial lung disease lack early bactericidal activity. ( 26647433 )
2016
23
The trend and the disease prediction of vascular endothelial growth factor and placenta growth factor in nontuberculous mycobacterial lung disease. ( 27876856 )
2016
24
Randomized Trial of Liposomal Amikacin for Inhalation in Nontuberculous Mycobacterial Lung Disease. ( 27748623 )
2016
25
Understanding nontuberculous mycobacterial lung disease: it's been a long time coming. ( 27990278 )
2016
26
Antibiotic treatment for nontuberculous mycobacterial lung disease. ( 26967761 )
2016
27
Diagnosis and Treatment of Nontuberculous Mycobacterial Lung Disease. ( 27134484 )
2016
28
Diagnosis and Treatment of Nontuberculous Mycobacterial Lung Disease: Clinicians' Perspectives. ( 27066084 )
2016
29
Pathogenesis and risk factors for nontuberculous mycobacterial lung disease. ( 25676515 )
2015
30
Factors associated with subsequent nontuberculous mycobacterial lung disease in patients with a single sputum isolate on initial examination. ( 25658545 )
2015
31
Preliminary Results of Bedaquiline as Salvage Therapy for Patients With Nontuberculous Mycobacterial Lung Disease. ( 25675393 )
2015
32
Nontuberculous Mycobacterial Lung Disease Caused by Mycobacterium simiae: The First Reported Case in South Korea. ( 26508940 )
2015
33
Nontuberculous mycobacterial lung disease accompanied by organizing pneumonia. ( 25876578 )
2015
34
Complications after video-assisted thoracic surgery in patients with pulmonary nontuberculous mycobacterial lung disease who underwent preoperative pulmonary rehabilitation. ( 26357436 )
2015
35
Treatment outcomes of adjuvant resectional surgery for nontuberculous mycobacterial lung disease. ( 25887191 )
2015
36
Nontuberculous Mycobacterial Lung Disease. Time to Get a Grip! ( 26448345 )
2015
37
Nontuberculous Mycobacterial Lung Disease Caused by Mycobacterium shinjukuense: The First Reported Case in Korea. ( 26508936 )
2015
38
Surgical treatment of nontuberculous mycobacterial lung disease. ( 24740640 )
2014
39
First case of nontuberculous mycobacterial lung disease caused by Mycobacterium marseillense in a patient with systemic lupus erythematosus. ( 24768296 )
2014
40
Comparison of clinical and laboratory findings between those with pulmonary tuberculosis and those with nontuberculous mycobacterial lung disease. ( 24964657 )
2014
41
The First Korean Case of Nontuberculous Mycobacterial Lung Disease Caused by Mycobacterium abscessus Subspecies bolletii in a Patient with Bronchiectasis. ( 24523815 )
2014
42
Diagnosis of pulmonary tuberculosis and nontuberculous mycobacterial lung disease in Korea. ( 25114696 )
2014
43
Lack of adherence to evidence-based treatment guidelines for nontuberculous mycobacterial lung disease. ( 24236749 )
2014
44
The impact of low subcutaneous fat in patients with nontuberculous mycobacterial lung disease. ( 24549334 )
2014
45
Clinical investigation of nontuberculous mycobacterial lung disease in Japanese patients with rheumatoid arthritis receiving biologic therapy. ( 24187100 )
2013
46
Phenotypic, immunologic, and clinical characteristics of patients with nontuberculous mycobacterial lung disease in Korea. ( 24274658 )
2013
47
Nontuberculous Mycobacterial Lung Disease Caused by Mycobacterium chelonae: A Case Report. ( 23678362 )
2013
48
Association of CFTR gene variants with nontuberculous mycobacterial lung disease in a Korean population with a low prevalence of cystic fibrosis. ( 23514810 )
2013
49
Nontuberculous Mycobacterial Lung Disease Caused by Mycobacterium lentiflavum in a Patient with Bronchiectasis. ( 23678361 )
2013
50
CT findings of pulmonary non-tuberculous mycobacterial infection in non-AIDS immunocompromised patients: a case-controlled comparison with immunocompetent patients. ( 23440166 )
2013

Variations for Nontuberculous Mycobacterial Lung Disease

Expression for Nontuberculous Mycobacterial Lung Disease

Search GEO for disease gene expression data for Nontuberculous Mycobacterial Lung Disease.

Pathways for Nontuberculous Mycobacterial Lung Disease

Pathways related to Nontuberculous Mycobacterial Lung Disease according to GeneCards Suite gene sharing:

(show all 25)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.65 HLA-A HLA-B HLA-DRB1 IL12B TNF
2
Show member pathways
12.39 HLA-DRB1 IL12B TLR2 TNF
3 12.14 HLA-A HLA-B HLA-DRB1 TNF
4
Show member pathways
12.03 CFTR TLR2 TNF
5
Show member pathways
11.98 CFTR TLR2 TNF
6
Show member pathways
11.98 HLA-DRB1 IL12B TLR2 TNF
7 11.92 HLA-A HLA-B HLA-DRB1
8 11.92 HLA-DRB1 IL12B TLR2 TNF
9 11.87 ADIPOQ LEP TNF
10
Show member pathways
11.86 IL12B TLR2 TNF
11 11.8 HLA-A HLA-B HLA-DRB1 TLR2
12
Show member pathways
11.79 HLA-A HLA-DRB1 IL12B
13
Show member pathways
11.76 BMP6 HLA-A HLA-B IL12B TNF
14 11.69 IL12B TLR2 TNF
15 11.66 HLA-DRB1 TLR2 TNF
16
Show member pathways
11.58 HLA-A HLA-B HLA-DRB1 IL12B TLR2 TNF
17 11.49 ADIPOQ LEP TNF
18 11.37 IL12B TLR2 TNF
19 11.29 IL12B TLR2 TNF
20 11.02 BMP6 IL12B TNF
21 11 HLA-A HLA-B
22 11 ADIPOQ LEP
23 10.9 HLA-DRB1 IL12B TNF
24 10.83 BMP6 FBN1 IL12B TNF
25 10.47 ADIPOQ LEP TNF

GO Terms for Nontuberculous Mycobacterial Lung Disease

Cellular components related to Nontuberculous Mycobacterial Lung Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.93 ADIPOQ BMP6 FBN1 IL12B LEP TNF
2 integral component of plasma membrane GO:0005887 9.88 CFTR HLA-A HLA-B SLC11A1 TLR2 TNF
3 early endosome membrane GO:0031901 9.61 CFTR HLA-A HLA-B
4 recycling endosome membrane GO:0055038 9.5 CFTR HLA-A HLA-B
5 ER to Golgi transport vesicle membrane GO:0012507 9.43 HLA-A HLA-B HLA-DRB1
6 MHC class I protein complex GO:0042612 9.37 HLA-A HLA-B
7 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.33 HLA-A HLA-B HLA-DRB1
8 phagocytic vesicle membrane GO:0030670 9.26 HLA-A HLA-B SLC11A1 TLR2
9 cell surface GO:0009986 9.23 ADIPOQ CFTR HLA-A HLA-B HLA-DRB1 IL12B

Biological processes related to Nontuberculous Mycobacterial Lung Disease according to GeneCards Suite gene sharing:

(show all 36)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.91 BMP6 SLC11A1 TLR2 TNF
2 response to hypoxia GO:0001666 9.84 ADIPOQ LEP TLR2
3 positive regulation of inflammatory response GO:0050729 9.73 IL12B TLR2 TNF
4 interferon-gamma-mediated signaling pathway GO:0060333 9.71 HLA-A HLA-B HLA-DRB1
5 response to glucocorticoid GO:0051384 9.7 ADIPOQ BMP6 TNF
6 glucose metabolic process GO:0006006 9.69 ADIPOQ LEP TNF
7 antigen processing and presentation of peptide antigen via MHC class I GO:0002474 9.67 HLA-A HLA-B
8 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002479 9.67 HLA-A HLA-B
9 positive regulation of interleukin-12 production GO:0032735 9.66 IL12B TLR2
10 positive regulation of interleukin-10 production GO:0032733 9.65 IL12B TLR2
11 positive regulation of osteoclast differentiation GO:0045672 9.65 IL12B TNF
12 defense response to protozoan GO:0042832 9.65 IL12B SLC11A1
13 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.65 IL12B TLR2 TNF
14 positive regulation of chemokine production GO:0032722 9.64 TLR2 TNF
15 microglial cell activation GO:0001774 9.64 TLR2 TNF
16 leukocyte tethering or rolling GO:0050901 9.63 LEP TNF
17 negative regulation of glucose import GO:0046325 9.63 LEP TNF
18 positive regulation of tumor necrosis factor production GO:0032760 9.63 IL12B LEP TLR2
19 negative regulation of growth of symbiont in host GO:0044130 9.62 IL12B TNF
20 negative regulation of phagocytosis GO:0050765 9.62 ADIPOQ TLR2
21 sexual reproduction GO:0019953 9.61 IL12B LEP
22 positive regulation of interferon-gamma production GO:0032729 9.61 IL12B SLC11A1 TNF
23 positive regulation of T-helper 1 type immune response GO:0002827 9.6 IL12B SLC11A1
24 T-helper 1 type immune response GO:0042088 9.59 HLA-DRB1 IL12B
25 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002480 9.58 HLA-A HLA-B
26 multicellular organismal iron ion homeostasis GO:0060586 9.58 BMP6 SLC11A1
27 response to activity GO:0014823 9.58 ADIPOQ BMP6 LEP
28 negative regulation of lipid storage GO:0010888 9.57 LEP TNF
29 antigen processing and presentation of endogenous peptide antigen via MHC class Ib GO:0002476 9.55 HLA-A HLA-B
30 antigen processing and presentation GO:0019882 9.54 HLA-A HLA-B HLA-DRB1
31 positive regulation of cytokine production GO:0001819 9.5 LEP SLC11A1 TNF
32 protection from natural killer cell mediated cytotoxicity GO:0042270 9.49 HLA-A HLA-B
33 positive regulation of interleukin-8 production GO:0032757 9.43 ADIPOQ TLR2 TNF
34 regulation of signaling receptor activity GO:0010469 9.43 ADIPOQ BMP6 FBN1 IL12B LEP TNF
35 positive regulation of T cell mediated cytotoxicity GO:0001916 9.33 HLA-A HLA-B IL12B
36 immune response GO:0006955 9.17 BMP6 HLA-A HLA-B HLA-DRB1 SLC11A1 TLR2

Molecular functions related to Nontuberculous Mycobacterial Lung Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.72 ADIPOQ FBN1 IL12B TLR2 TNF
2 signaling receptor binding GO:0005102 9.56 ADIPOQ HLA-A HLA-B LEP
3 hormone activity GO:0005179 9.33 ADIPOQ FBN1 LEP
4 cytokine activity GO:0005125 9.26 ADIPOQ BMP6 IL12B TNF
5 peptide antigen binding GO:0042605 8.8 HLA-A HLA-B HLA-DRB1

Sources for Nontuberculous Mycobacterial Lung Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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