MCID: NNT049
MIFTS: 47

Nontuberculous Mycobacterial Lung Disease

Categories: Infectious diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Nontuberculous Mycobacterial Lung Disease

MalaCards integrated aliases for Nontuberculous Mycobacterial Lung Disease:

Name: Nontuberculous Mycobacterial Lung Disease 20
Pulmonary Non-Tuberculous Mycobacterial Infection 20 58
Non-Tuberculous Mycobacterial Lung Disease 20 58

Characteristics:

Orphanet epidemiological data:

58
pulmonary non-tuberculous mycobacterial infection
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

Orphanet: 58  
Rare respiratory diseases
Rare infectious diseases


Summaries for Nontuberculous Mycobacterial Lung Disease

GARD : 20 Nontuberculous mycobacterial (NTM) lung disease is an infectious condition caused by certain types of mycobacteria. Some people with NTM lung disease have no signs or symptoms, while others experience a severe cough, hemoptysis (coughing up blood), shortness of breath, fatigue, fever, night sweats and/or weightloss. Mycobacteria are found naturally in soil and water. Most people who are exposed to these bacteria do not become sick. However, people who have a weakened immune system or other health conditions (i.e. chronic obstructive pulmonary disease, bronchiectasis, pneumoconiosis, cystic fibrosis, and previous tuberculosis ) have an elevated risk of developing NTM lung disease. The condition is generally treated with a combination of antibiotics which is often continued until certain tests have been negative for 12 months. In some cases, surgery may be recommended if lung tissue is damaged.

MalaCards based summary : Nontuberculous Mycobacterial Lung Disease, also known as pulmonary non-tuberculous mycobacterial infection, is related to lung disease and bronchiectasis. An important gene associated with Nontuberculous Mycobacterial Lung Disease is TLR2 (Toll Like Receptor 2), and among its related pathways/superpathways are Allograft rejection and Th17 cell differentiation. The drug Nitric Oxide has been mentioned in the context of this disorder. Affiliated tissues include lung, heart and kidney, and related phenotypes are elevated erythrocyte sedimentation rate and cough

Related Diseases for Nontuberculous Mycobacterial Lung Disease

Diseases related to Nontuberculous Mycobacterial Lung Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 214)
# Related Disease Score Top Affiliating Genes
1 lung disease 31.5 TNF TLR2 CFTR BMP6
2 bronchiectasis 31.3 TNF TLR2 CFTR
3 mycobacterium abscessus 31.2 TNF TLR2 CFTR
4 bronchitis 30.2 TNF TLR2 CFTR
5 aspergillosis 30.2 TNF TLR2 CFTR
6 pneumonia 30.1 TNF TLR2 CFTR
7 pulmonary tuberculosis 30.0 TNF TLR2 SLC11A1 IL12B HLA-DRB1
8 mycobacterium tuberculosis 1 29.9 TNF TLR2 SLC11A1 IL12B
9 disease by infectious agent 29.8 TNF TLR2 SLC11A1 CFTR
10 rheumatoid arthritis 29.5 TNF TLR2 SLC11A1 HLA-DRB1 HLA-B
11 arthritis 29.3 TNF TLR2 SLC11A1 HLA-DRB1 HLA-B
12 mycobacterium kansasii 10.5
13 pectus excavatum 10.4
14 scoliosis 10.4
15 bronchiolitis 10.4
16 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.3
17 pulmonary disease, chronic obstructive 10.3
18 frontal fibrosing alopecia 10.3 HLA-B HLA-A
19 stevens-johnson syndrome/toxic epidermal necrolysis 10.3 HLA-B HLA-A
20 epstein-barr virus hepatitis 10.3 HLA-B HLA-A
21 caplan's syndrome 10.3 HLA-DRB1 HLA-A
22 selective igg deficiency disease 10.3 HLA-B HLA-A
23 colorectal cancer, hereditary nonpolyposis, type 8 10.3 HLA-B HLA-A
24 orthostatic intolerance 10.3
25 panbronchiolitis, diffuse 10.3
26 body mass index quantitative trait locus 1 10.3
27 mycobacterium fortuitum 10.3
28 chronic pyelonephritis 10.2 HLA-B HLA-A
29 haemophilus influenzae 10.2 TNF TLR2
30 drug reaction with eosinophilia and systemic symptoms 10.2 TNF HLA-B
31 autoimmune hepatitis type 1 10.2 HLA-DRB1 BMP6
32 superficial basal cell carcinoma 10.2 TNF TLR2
33 spondylarthropathy 10.2 TNF HLA-B
34 beryllium disease 10.2 TNF HLA-DRB1
35 pneumonic tularemia 10.2 TNF TLR2
36 pneumonic plague 10.2 TNF TLR2
37 chronic beryllium disease 10.2 TNF HLA-DRB1
38 tuberculous meningitis 10.2 TNF TLR2
39 hypopyon 10.2 TNF HLA-B
40 systemic onset juvenile idiopathic arthritis 10.2 TNF HLA-DRB1
41 salpingitis 10.2 TNF TLR2
42 actinic prurigo 10.1 TNF HLA-DRB1
43 contractural arachnodactyly, congenital 10.1
44 ear folding 10.1
45 carcinoid syndrome 10.1
46 eosinophilia-myalgia syndrome 10.1 HLA-DRB1 BMP6
47 rheumatoid vasculitis 10.1 TNF HLA-DRB1
48 postherpetic neuralgia 10.1 HLA-DRB1 HLA-B HLA-A
49 htlv-1 associated myelopathy/tropical spastic paraparesis 10.1 HLA-DRB1 HLA-B HLA-A
50 haemophilus meningitis 10.1 TNF HLA-A

Graphical network of the top 20 diseases related to Nontuberculous Mycobacterial Lung Disease:



Diseases related to Nontuberculous Mycobacterial Lung Disease

Symptoms & Phenotypes for Nontuberculous Mycobacterial Lung Disease

Human phenotypes related to Nontuberculous Mycobacterial Lung Disease:

58 31 (show all 22)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 elevated erythrocyte sedimentation rate 58 31 hallmark (90%) Very frequent (99-80%) HP:0003565
2 cough 58 31 frequent (33%) Frequent (79-30%) HP:0012735
3 bronchiectasis 58 31 frequent (33%) Frequent (79-30%) HP:0002110
4 asthenia 58 31 frequent (33%) Frequent (79-30%) HP:0025406
5 pulmonary opacity 58 31 frequent (33%) Frequent (79-30%) HP:0031457
6 fever 58 31 occasional (7.5%) Occasional (29-5%) HP:0001945
7 hemoptysis 58 31 occasional (7.5%) Occasional (29-5%) HP:0002105
8 chest pain 58 31 occasional (7.5%) Occasional (29-5%) HP:0100749
9 weight loss 58 31 occasional (7.5%) Occasional (29-5%) HP:0001824
10 respiratory distress 58 31 occasional (7.5%) Occasional (29-5%) HP:0002098
11 pleural effusion 58 31 occasional (7.5%) Occasional (29-5%) HP:0002202
12 diarrhea 58 31 occasional (7.5%) Occasional (29-5%) HP:0002014
13 lymphadenopathy 58 31 occasional (7.5%) Occasional (29-5%) HP:0002716
14 pericardial effusion 58 31 occasional (7.5%) Occasional (29-5%) HP:0001698
15 crackles 58 31 occasional (7.5%) Occasional (29-5%) HP:0030830
16 mycobacterium abscessus abscessus infection 58 31 occasional (7.5%) Occasional (29-5%) HP:0032130
17 disseminated nontuberculous mycobacterial infection 58 31 occasional (7.5%) Occasional (29-5%) HP:0032283
18 chronic pulmonary obstruction 31 occasional (7.5%) HP:0006510
19 pneumothorax 58 31 very rare (1%) Very rare (<4-1%) HP:0002107
20 dyspnea 58 Occasional (29-5%)
21 chronic obstructive pulmonary disease 58 Occasional (29-5%)
22 abnormal sputum 58 Frequent (79-30%)

MGI Mouse Phenotypes related to Nontuberculous Mycobacterial Lung Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.91 ADIPOQ CFTR FBN1 HLA-A IL12B LEP
2 endocrine/exocrine gland MP:0005379 9.87 ADIPOQ CFTR FBN1 HLA-A LEP TLR2
3 digestive/alimentary MP:0005381 9.85 CFTR IL12B LEP SLC11A1 TLR2 TNF
4 immune system MP:0005387 9.81 ADIPOQ CFTR FBN1 HLA-A IL12B LEP
5 neoplasm MP:0002006 9.43 ADIPOQ IL12B LEP SLC11A1 TLR2 TNF
6 respiratory system MP:0005388 9.17 ADIPOQ CFTR FBN1 IL12B LEP TLR2

Drugs & Therapeutics for Nontuberculous Mycobacterial Lung Disease

Drugs for Nontuberculous Mycobacterial Lung Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nitric Oxide Approved Phase 2 10102-43-9 145068

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Proof of Concept Study of Inhaled Nitric Oxide for Adults With Pulmonary Non-Tuberculous Mycobacterial Infection Completed NCT03748992 Phase 2 gNO
2 A Randomized, Double-Blind, Placebo-Controlled Study of Liposomal Amikacin for Inhalation in Patients With Recalcitrant Nontuberculous Mycobacterial Lung Disease Completed NCT01315236 Phase 2 Liposomal amikacin for inhalation (LAI);placebo
3 Recombinant Interleukin-7 (CYT107) to Treat Patients With Refractory Nontuberculous Mycobacterial Lung Disease. Two Doses Phase II, Single Center, Open-label Trial Recruiting NCT04154826 Phase 2 Recombinant human interleukin-7
4 Inhaled Amikacin for Treatment of Intractable Nontuberculous Mycobacterial Lung Disease Withdrawn NCT01528930 Phase 2 Amikacin
5 Elucidation of Genetic Susceptibility of Patients With Nontuberculous Mycobacterial Lung Disease Using Genome-Wide Association Study Completed NCT02832843
6 Diagnostic Accuracy and Inter-rater Agreement of Chest Computed Tomography in the Diagnosis of Nontuberculous Mycobacterial Lung Disease Completed NCT02340897
7 Identification of Host Susceptibility Factors and Development of Biomarkers for Diagnosis, Prognosis and Treatment of Nontuberculous Mycobacterial Lung Disease Recruiting NCT00970801

Search NIH Clinical Center for Nontuberculous Mycobacterial Lung Disease

Genetic Tests for Nontuberculous Mycobacterial Lung Disease

Anatomical Context for Nontuberculous Mycobacterial Lung Disease

MalaCards organs/tissues related to Nontuberculous Mycobacterial Lung Disease:

40
Lung, Heart, Kidney, Placenta, Endothelial, Bone, Liver

Publications for Nontuberculous Mycobacterial Lung Disease

Articles related to Nontuberculous Mycobacterial Lung Disease:

(show top 50) (show all 157)
# Title Authors PMID Year
1
Predictors of starting antimicrobial treatment in patients with nontuberculous mycobacterial lung disease in the Italian scenario: A SITA GIOVANI-IRENE promoted web-survey. 61
33618080 2021
2
Automated Lung Segmentation on Chest Computed Tomography Images with Extensive Lung Parenchymal Abnormalities Using a Deep Neural Network. 61
33169549 2021
3
Population Pharmacokinetic Evaluation of Amikacin Liposome Inhalation Suspension in Patients with Treatment-Refractory Nontuberculous Mycobacterial Lung Disease. 61
33595792 2021
4
Role of Soluble T-Cell Immunoglobulin Mucin Domain-3 in Differentiating Nontuberculous Mycobacterial Lung Disease from Pulmonary Colonization. 61
33745754 2021
5
A multidisciplinary approach to the management of nontuberculous mycobacterial lung disease: a clinical perspective. 61
33593217 2021
6
Symptom Burden and Medication Use Among Patients With Nontuberculous Mycobacterial Lung Disease. 61
33610137 2021
7
Inaugural nontuberculous mycobacterial lung disease education and research conference, Honolulu, Hawai'i, February 1-2, 2020. 61
33035706 2021
8
Is the Leicester Cough Questionnaire useful for nontuberculous mycobacterial lung disease? 61
32800755 2021
9
Extensive Lung Resection for Nontuberculous Mycobacterial Lung Disease With Multilobar Lesions. 61
32621813 2021
10
Serum Krebs von den Lungen-6 level in the disease progression and treatment of Mycobacterium avium complex lung disease. 61
32602203 2021
11
CD64 expression on neutrophils reflects the activity of nontuberculous mycobacterial lung disease. 61
33046420 2021
12
Novel Assays/Applications for Patients Suspected of Mycobacterial Diseases. 61
33121621 2020
13
Identification of potentially undiagnosed patients with nontuberculous mycobacterial lung disease using machine learning applied to primary care data in the UK. 61
32430411 2020
14
Real-world treatment patterns in patients with nontuberculous mycobacterial lung disease in general and pneumologist practices in Germany. 61
32802970 2020
15
Prognostic nutritional index as a predictor of mortality in nontuberculous mycobacterial lung disease. 61
32642232 2020
16
Time to be familiar with nontuberculous mycobacterial lung disease - An emerging disease with diverse clinical outcomes. 61
32600572 2020
17
Recent advances and controversies in surgical intervention of nontuberculous mycobacterial lung disease: A literature review. 61
32389416 2020
18
Nonpharmacological treatment for patients with nontuberculous mycobacterial lung disease. 61
32499207 2020
19
Nontuberculous mycobacterial lung disease epidemiology in Taiwan: A systematic review. 61
32482605 2020
20
Host immune response against environmental nontuberculous mycobacteria and the risk populations of nontuberculous mycobacterial lung disease. 61
32451216 2020
21
Comparison of the chest computed tomography findings between patients with pulmonary tuberculosis and those with Mycobacterium avium complex lung disease. 61
32102768 2020
22
Clinical features and treatment outcomes of Mycobacterium chimaera lung disease and antimicrobial susceptibility of the mycobacterial isolates. 61
31954743 2020
23
Incidence and Prevalence of Nontuberculous Mycobacterial Lung Disease in a Large U.S. Managed Care Health Plan, 2008-2015. 61
31830805 2020
24
The Quest for Systematic Epidemiology of Nontuberculous Mycobacterial Lung Disease in the United States: Closing in on an Elusive Goal. 61
32003606 2020
25
In reply-Amikacin Liposome Inhalation Suspension as a Treatment Option for Refractory Nontuberculous Mycobacterial Lung Disease Caused by Mycobacterium avium Complex. 61
31902420 2020
26
Amikacin Liposome Inhalation Suspension as a Treatment Option for Refractory Nontuberculous Mycobacterial Lung Disease Caused by Mycobacterium avium Complex. 61
31902419 2020
27
Incremental Shuttle Walk Distance as an Indicator for Functional Exercise Capacity of Pre-Surgical Patients with Nontuberculous Mycobacterial Lung Disease. 61
31996491 2020
28
The Use of Amikacin Liposome Inhalation Suspension (Arikayce) in the Treatment of Refractory Nontuberculous Mycobacterial Lung Disease in Adults. 61
32606598 2020
29
[Clinical characteristics and drug susceptibility test of nontuberculous mycobacterial lung disease]. 61
31826533 2019
30
[The clinical analysis of chronic obstructive pulmonary disease patients complicated with nontuberculous mycobacterial pulmonary disease]. 61
31694092 2019
31
Evaluating differences in tuberculosis and nontuberculous mycobacterial lung disease in Florida. 61
31204093 2019
32
Clinical and radiological features of pulmonary tuberculosis in patients with idiopathic pulmonary fibrosis. 61
31563638 2019
33
Guidelines-based treatment associated with improved economic outcomes in nontuberculous mycobacterial lung disease. 61
31094592 2019
34
Revisiting John Snow to Meet the Challenge of Nontuberculous Mycobacterial Lung Disease. 61
31683836 2019
35
Changing epidemiology of nontuberculous mycobacterial lung disease over the last two decades in a region of the Basque country. 61
31720298 2019
36
Genetic relatedness of Mycobacterium avium subsp. hominissuis isolates from bathrooms of healthy volunteers, rivers, and soils in Japan with human clinical isolates from different geographical areas. 61
31207401 2019
37
Inhaled Antibiotics for Mycobacterial Lung Disease. 61
31331119 2019
38
Hemoptysis requiring bronchial artery embolization in patients with nontuberculous mycobacterial lung disease. 61
31248409 2019
39
Assessment of 7 trace elements in serum of patients with nontuberculous mycobacterial lung disease. 61
30910213 2019
40
Infection Source and Epidemiology of Nontuberculous Mycobacterial Lung Disease. 61
30302953 2019
41
Development of lung cancer in patients with nontuberculous mycobacterial lung disease. 61
30598398 2019
42
Microbiome Diversity in Sputum of Nontuberculous Mycobacteria Infected Women with a History of Breast Cancer. 61
30816674 2019
43
Amikacin Liposome Inhalation Suspension for Treatment-Refractory Lung Disease Caused by Mycobacterium avium Complex (CONVERT). A Prospective, Open-Label, Randomized Study. 61
30216086 2018
44
A retrospective study of factors associated with treatment decision for nontuberculous mycobacterial lung disease in adults without altered systemic immunity. 61
30547753 2018
45
Relative risk of all-cause mortality in patients with nontuberculous mycobacterial lung disease in a US managed care population. 61
30509721 2018
46
Health Care Utilization and Expenditures Following Diagnosis of Nontuberculous Mycobacterial Lung Disease in the United States. 61
30028225 2018
47
Nontuberculous Mycobacterial Lung Diseases Caused by Mixed Infection with Mycobacterium avium Complex and Mycobacterium abscessus Complex. 61
30104265 2018
48
The cost of Mycobacterium avium complex lung disease in Canada, France, Germany, and the United Kingdom: a nationally representative observational study. 61
30200944 2018
49
Amikacin Inhalation as Salvage Therapy for Refractory Nontuberculous Mycobacterial Lung Disease. 61
29661870 2018
50
Sputum Detection of Predisposing Genetic Mutations in Women with Pulmonary Nontuberculous Mycobacterial Disease. 61
30054559 2018

Variations for Nontuberculous Mycobacterial Lung Disease

Expression for Nontuberculous Mycobacterial Lung Disease

Search GEO for disease gene expression data for Nontuberculous Mycobacterial Lung Disease.

Pathways for Nontuberculous Mycobacterial Lung Disease

Pathways related to Nontuberculous Mycobacterial Lung Disease according to GeneCards Suite gene sharing:

(show all 26)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.63 TNF IL12B HLA-DRB1 HLA-B HLA-A
2
Show member pathways
12.42 TNF TLR2 IL12B HLA-DRB1
3 12.17 TNF HLA-DRB1 HLA-B HLA-A
4
Show member pathways
12.14 TNF TLR2 IL12B HLA-DRB1 HLA-B HLA-A
5
Show member pathways
12.05 TNF TLR2 CFTR
6
Show member pathways
12.03 TNF TLR2 IL12B HLA-DRB1
7
Show member pathways
12 TNF TLR2 CFTR
8 11.99 TNF TLR2 IL12B HLA-DRB1
9 11.95 HLA-DRB1 HLA-B HLA-A
10
Show member pathways
11.93 TNF IL12B HLA-B HLA-A BMP6
11 11.9 TNF LEP ADIPOQ
12 11.89 TLR2 HLA-DRB1 HLA-B HLA-A
13
Show member pathways
11.82 IL12B HLA-DRB1 HLA-A
14 11.8 TNF TLR2 IL12B HLA-DRB1 HLA-B HLA-A
15 11.76 TNF TLR2 IL12B
16 11.72 TNF FBN1 BMP6
17 11.7 TNF TLR2 HLA-DRB1
18
Show member pathways
11.6 TNF TLR2 IL12B
19 11.55 TNF LEP ADIPOQ
20 11.44 TNF TLR2 IL12B
21 11.43 LEP HLA-A BMP6 ADIPOQ
22 11.33 TNF TLR2 IL12B
23 11.02 LEP ADIPOQ
24 11.02 HLA-B HLA-A
25 11.01 TNF IL12B HLA-DRB1
26 10.78 TNF LEP ADIPOQ

GO Terms for Nontuberculous Mycobacterial Lung Disease

Cellular components related to Nontuberculous Mycobacterial Lung Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.91 TNF LEP IL12B HLA-DRB1 FBN1 BMP6
2 integral component of plasma membrane GO:0005887 9.8 TNF TLR2 SLC11A1 HLA-DRB1 HLA-B HLA-A
3 early endosome membrane GO:0031901 9.63 HLA-B HLA-A CFTR
4 recycling endosome membrane GO:0055038 9.58 HLA-B HLA-A CFTR
5 ER to Golgi transport vesicle membrane GO:0012507 9.5 HLA-DRB1 HLA-B HLA-A
6 MHC class I protein complex GO:0042612 9.43 HLA-B HLA-A
7 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.33 HLA-DRB1 HLA-B HLA-A
8 phagocytic vesicle membrane GO:0030670 9.26 TLR2 SLC11A1 HLA-B HLA-A
9 cell surface GO:0009986 9.23 TNF TLR2 IL12B HLA-DRB1 HLA-B HLA-A

Biological processes related to Nontuberculous Mycobacterial Lung Disease according to GeneCards Suite gene sharing:

(show all 36)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.97 TNF TLR2 SLC11A1 BMP6
2 inflammatory response GO:0006954 9.94 TNF TLR2 SLC11A1 BMP6
3 response to hypoxia GO:0001666 9.85 TLR2 LEP ADIPOQ
4 defense response to Gram-positive bacterium GO:0050830 9.8 TNF TLR2 HLA-A
5 positive regulation of inflammatory response GO:0050729 9.79 TNF TLR2 IL12B
6 positive regulation of tumor necrosis factor production GO:0032760 9.77 TLR2 LEP IL12B
7 interferon-gamma-mediated signaling pathway GO:0060333 9.72 HLA-DRB1 HLA-B HLA-A
8 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.71 TNF LEP IL12B
9 positive regulation of protein phosphorylation GO:0001934 9.71 TNF LEP HLA-DRB1 ADIPOQ
10 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.7 TNF TLR2 IL12B
11 response to glucocorticoid GO:0051384 9.69 TNF BMP6 ADIPOQ
12 defense response to protozoan GO:0042832 9.66 SLC11A1 IL12B
13 positive regulation of osteoclast differentiation GO:0045672 9.66 TNF IL12B
14 regulation of fat cell differentiation GO:0045598 9.65 TNF LEP
15 leukocyte tethering or rolling GO:0050901 9.65 TNF LEP
16 negative regulation of phagocytosis GO:0050765 9.65 TLR2 ADIPOQ
17 glucose metabolic process GO:0006006 9.65 TNF LEP ADIPOQ
18 negative regulation of glucose import GO:0046325 9.64 TNF LEP
19 negative regulation of inflammatory response to antigenic stimulus GO:0002862 9.63 IL12B HLA-DRB1
20 positive regulation of interleukin-8 production GO:0032757 9.63 TNF TLR2 ADIPOQ
21 positive regulation of T-helper 1 type immune response GO:0002827 9.62 SLC11A1 IL12B
22 T-helper 1 type immune response GO:0042088 9.61 IL12B HLA-DRB1
23 sexual reproduction GO:0019953 9.61 LEP IL12B
24 positive regulation of cytokine production GO:0001819 9.61 TNF SLC11A1 LEP
25 positive regulation of memory T cell differentiation GO:0043382 9.59 IL12B HLA-DRB1
26 negative regulation of lipid storage GO:0010888 9.58 TNF LEP
27 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002480 9.58 HLA-B HLA-A
28 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent GO:0002486 9.57 HLA-B HLA-A
29 multicellular organismal iron ion homeostasis GO:0060586 9.56 SLC11A1 BMP6
30 response to activity GO:0014823 9.54 LEP BMP6 ADIPOQ
31 antigen processing and presentation GO:0019882 9.5 HLA-DRB1 HLA-B HLA-A
32 immune response GO:0006955 9.5 TNF TLR2 SLC11A1 HLA-DRB1 HLA-B HLA-A
33 protection from natural killer cell mediated cytotoxicity GO:0042270 9.49 HLA-B HLA-A
34 positive regulation of interferon-gamma production GO:0032729 9.46 TNF SLC11A1 IL12B HLA-A
35 detection of bacterium GO:0016045 9.43 HLA-DRB1 HLA-B HLA-A
36 positive regulation of T cell mediated cytotoxicity GO:0001916 8.92 IL12B HLA-DRB1 HLA-B HLA-A

Molecular functions related to Nontuberculous Mycobacterial Lung Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.67 LEP HLA-B HLA-A ADIPOQ
2 hormone activity GO:0005179 9.5 LEP FBN1 ADIPOQ
3 cytokine activity GO:0005125 9.46 TNF IL12B BMP6 ADIPOQ
4 T cell receptor binding GO:0042608 9.26 HLA-DRB1 HLA-A
5 TAP binding GO:0046977 8.96 HLA-B HLA-A
6 peptide antigen binding GO:0042605 8.8 HLA-DRB1 HLA-B HLA-A

Sources for Nontuberculous Mycobacterial Lung Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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