MCID: NNT049
MIFTS: 40

Nontuberculous Mycobacterial Lung Disease

Categories: Infectious diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Nontuberculous Mycobacterial Lung Disease

MalaCards integrated aliases for Nontuberculous Mycobacterial Lung Disease:

Name: Nontuberculous Mycobacterial Lung Disease 52
Pulmonary Non-Tuberculous Mycobacterial Infection 52 58
Non-Tuberculous Mycobacterial Lung Disease 52 58

Characteristics:

Orphanet epidemiological data:

58
pulmonary non-tuberculous mycobacterial infection
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

Orphanet: 58  
Rare respiratory diseases
Rare infectious diseases


External Ids:

ICD10 via Orphanet 33 A31.0
Orphanet 58 ORPHA411703

Summaries for Nontuberculous Mycobacterial Lung Disease

NIH Rare Diseases : 52 Nontuberculous mycobacterial (NTM) lung disease is an infectious condition caused by certain types of mycobacteria . Some people with NTM lung disease have no signs or symptoms, while others experience a severe cough, hemoptysis (coughing up blood), shortness of breath, fatigue, fever, night sweats and/or weightloss. Mycobacteria are found naturally in soil and water. Most people who are exposed to these bacteria do not become sick. However, people who have a weakened immune system or other health conditions (i.e. chronic obstructive pulmonary disease , bronchiectasis , pneumoconiosis , cystic fibrosis , and previous tuberculosis ) have an elevated risk of developing NTM lung disease. The condition is generally treated with a combination of antibiotics which is often continued until certain tests have been negative for 12 months. In some cases, surgery may be recommended if lung tissue is damaged.

MalaCards based summary : Nontuberculous Mycobacterial Lung Disease, also known as pulmonary non-tuberculous mycobacterial infection, is related to bronchiectasis and mycobacterium abscessus. An important gene associated with Nontuberculous Mycobacterial Lung Disease is TLR2 (Toll Like Receptor 2), and among its related pathways/superpathways are Allograft rejection and Th17 cell differentiation. The drugs Nitric Oxide and Neurotransmitter Agents have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and breast, and related phenotypes are hematopoietic system and immune system

Related Diseases for Nontuberculous Mycobacterial Lung Disease

Diseases related to Nontuberculous Mycobacterial Lung Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 212)
# Related Disease Score Top Affiliating Genes
1 bronchiectasis 31.3 TNF TLR2 CFTR
2 mycobacterium abscessus 31.2 TNF TLR2 CFTR
3 lung disease 31.1 TNF TLR2 SLC11A1 CFTR BMP6
4 bronchitis 30.2 TNF TLR2 CFTR
5 aspergillosis 30.2 TNF TLR2 CFTR
6 pulmonary tuberculosis 29.7 TNF TLR2 SLC11A1 IL12B HLA-DRB1
7 rheumatoid arthritis 29.3 TNF TLR2 SLC11A1 HLA-DRB1 HLA-B
8 mycobacterium kansasii 10.4
9 scoliosis 10.4
10 bronchiolitis 10.4
11 gastrointestinal tularemia 10.4 TLR2 SLC11A1
12 pectus excavatum 10.3
13 scleroderma, familial progressive 10.3 FBN1 BMP6
14 haemophilus influenzae 10.3 TNF TLR2
15 phenytoin or carbamazepine toxicity 10.2 HLA-B HLA-A
16 lung cancer 10.2
17 orthostatic intolerance 10.2
18 panbronchiolitis, diffuse 10.2
19 pulmonary disease, chronic obstructive 10.2
20 mycobacterium fortuitum 10.2
21 congenital cytomegalovirus 10.2 TNF TLR2
22 rheumatoid factor-negative juvenile idiopathic arthritis 10.2 SLC11A1 HLA-DRB1
23 spondylarthropathy 10.2 TNF TLR2
24 non-alcoholic steatohepatitis 10.2 TNF ADIPOQ
25 post-transplant lymphoproliferative disease 10.2 TNF SLC11A1
26 pneumonic tularemia 10.2 TNF TLR2
27 tuberculous meningitis 10.2 TNF TLR2
28 autoimmune hepatitis type 1 10.2 HLA-DRB1 BMP6
29 chlamydia pneumonia 10.2 TNF TLR2
30 colorectal cancer, hereditary nonpolyposis, type 8 10.2 HLA-B HLA-A
31 salpingitis 10.2 TNF TLR2
32 contractural arachnodactyly, congenital 10.1
33 ear folding 10.1
34 bronchiolitis obliterans 10.1
35 mycobacterium gordonae 10.1
36 drug reaction with eosinophilia and systemic symptoms 10.1 TNF HLA-B
37 stevens-johnson syndrome/toxic epidermal necrolysis 10.1 HLA-B HLA-A
38 pulmonary hypertension, primary, 1 10.1
39 pulmonary hypertension, chronic thromboembolic, without deep vein thrombosis 10.1
40 pulmonary hypertension 10.1
41 chronic thromboembolic pulmonary hypertension 10.1
42 periapical periodontitis 10.1 TNF TLR2
43 dental pulp disease 10.1 TNF TLR2
44 diffuse cutaneous systemic sclerosis 10.1 HLA-DRB1 FBN1
45 gastroesophageal reflux 10.1
46 systemic lupus erythematosus 10.1
47 marfan syndrome 10.1
48 cystic fibrosis 10.1
49 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.1
50 body mass index quantitative trait locus 1 10.1

Graphical network of the top 20 diseases related to Nontuberculous Mycobacterial Lung Disease:



Diseases related to Nontuberculous Mycobacterial Lung Disease

Symptoms & Phenotypes for Nontuberculous Mycobacterial Lung Disease

MGI Mouse Phenotypes related to Nontuberculous Mycobacterial Lung Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.92 ADIPOQ CFTR FBN1 IL12B LEP SLC11A1
2 immune system MP:0005387 9.86 ADIPOQ CFTR FBN1 IL12B LEP SLC11A1
3 digestive/alimentary MP:0005381 9.85 CFTR IL12B LEP SLC11A1 TLR2 TNF
4 neoplasm MP:0002006 9.63 ADIPOQ IL12B LEP SLC11A1 TLR2 TNF
5 respiratory system MP:0005388 9.5 ADIPOQ CFTR FBN1 IL12B LEP TLR2
6 skeleton MP:0005390 9.17 ADIPOQ BMP6 FBN1 IL12B LEP TLR2

Drugs & Therapeutics for Nontuberculous Mycobacterial Lung Disease

Drugs for Nontuberculous Mycobacterial Lung Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nitric Oxide Approved Phase 2 10102-43-9 145068
2 Neurotransmitter Agents Phase 2
3 Respiratory System Agents Phase 2
4 Anti-Asthmatic Agents Phase 2
5 Protective Agents Phase 2
6 Free Radical Scavengers Phase 2
7 Vasodilator Agents Phase 2
8 Autonomic Agents Phase 2
9 Bronchodilator Agents Phase 2
10 Antioxidants Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Randomized, Double-Blind, Placebo-Controlled Study of Liposomal Amikacin for Inhalation in Patients With Recalcitrant Nontuberculous Mycobacterial Lung Disease Completed NCT01315236 Phase 2 Liposomal amikacin for inhalation (LAI);placebo
2 A Proof of Concept Study of Inhaled Nitric Oxide for Adults With Pulmonary Non-Tuberculous Mycobacterial Infection Enrolling by invitation NCT03748992 Phase 2 gNO
3 Recombinant Interleukin-7 (CYT107) to Treat Patients With Refractory Nontuberculous Mycobacterial Lung Disease. Two Doses Phase II, Single Center, Open-label Trial Not yet recruiting NCT04154826 Phase 2 Recombinant human interleukin-7
4 Inhaled Amikacin for Treatment of Intractable Nontuberculous Mycobacterial Lung Disease Withdrawn NCT01528930 Phase 2 Amikacin
5 Identification of Host Susceptibility Factors and Development of Biomarkers for Diagnosis, Prognosis and Treatment of Nontuberculous Mycobacterial Lung Disease Unknown status NCT00970801
6 Diagnostic Accuracy and Inter-rater Agreement of Chest Computed Tomography in the Diagnosis of Nontuberculous Mycobacterial Lung Disease Completed NCT02340897
7 Elucidation of Genetic Susceptibility of Patients With Nontuberculous Mycobacterial Lung Disease Using Genome-Wide Association Study Completed NCT02832843
8 Genetic Disorders of Mucociliary Clearance Completed NCT00368446

Search NIH Clinical Center for Nontuberculous Mycobacterial Lung Disease

Genetic Tests for Nontuberculous Mycobacterial Lung Disease

Anatomical Context for Nontuberculous Mycobacterial Lung Disease

MalaCards organs/tissues related to Nontuberculous Mycobacterial Lung Disease:

40
Lung, Testes, Breast, Placenta, Endothelial

Publications for Nontuberculous Mycobacterial Lung Disease

Articles related to Nontuberculous Mycobacterial Lung Disease:

(show top 50) (show all 130)
# Title Authors PMID Year
1
[Clinical characteristics and drug susceptibility test of nontuberculous mycobacterial lung disease]. 61
31826533 2019
2
Incidence and Prevalence of Nontuberculous Mycobacterial Lung Disease in a Large United States Managed Care Health Plan, 2008-2015. 61
31830805 2019
3
Revisiting John Snow to Meet the Challenge of Nontuberculous Mycobacterial Lung Disease. 61
31683836 2019
4
Evaluating differences in tuberculosis and nontuberculous mycobacterial lung disease in Florida. 61
31204093 2019
5
Guidelines-based treatment associated with improved economic outcomes in nontuberculous mycobacterial lung disease. 61
31094592 2019
6
Clinical and radiological features of pulmonary tuberculosis in patients with idiopathic pulmonary fibrosis. 61
31563638 2019
7
[The clinical analysis of chronic obstructive pulmonary disease patients complicated with nontuberculous mycobacterial pulmonary disease]. 61
31694092 2019
8
Changing epidemiology of nontuberculous mycobacterial lung disease over the last two decades in a region of the Basque country. 61
31720298 2019
9
Genetic relatedness of Mycobacterium avium subsp. hominissuis isolates from bathrooms of healthy volunteers, rivers, and soils in Japan with human clinical isolates from different geographical areas. 61
31207401 2019
10
Inhaled Antibiotics for Mycobacterial Lung Disease. 61
31331119 2019
11
Hemoptysis requiring bronchial artery embolization in patients with nontuberculous mycobacterial lung disease. 61
31248409 2019
12
Assessment of 7 trace elements in serum of patients with nontuberculous mycobacterial lung disease. 61
30910213 2019
13
Infection Source and Epidemiology of Nontuberculous Mycobacterial Lung Disease. 61
30302953 2019
14
Development of lung cancer in patients with nontuberculous mycobacterial lung disease. 61
30598398 2019
15
Microbiome Diversity in Sputum of Nontuberculous Mycobacteria Infected Women with a History of Breast Cancer. 61
30816674 2019
16
Relative risk of all-cause mortality in patients with nontuberculous mycobacterial lung disease in a US managed care population. 61
30509721 2018
17
A retrospective study of factors associated with treatment decision for nontuberculous mycobacterial lung disease in adults without altered systemic immunity. 61
30547753 2018
18
Amikacin Liposome Inhalation Suspension for Treatment-Refractory Lung Disease Caused by Mycobacterium avium Complex (CONVERT). A Prospective, Open-Label, Randomized Study. 61
30216086 2018
19
Health Care Utilization and Expenditures Following Diagnosis of Nontuberculous Mycobacterial Lung Disease in the United States. 61
30028225 2018
20
Nontuberculous Mycobacterial Lung Diseases Caused by Mixed Infection with Mycobacterium avium Complex and Mycobacterium abscessus Complex. 61
30104265 2018
21
The cost of Mycobacterium avium complex lung disease in Canada, France, Germany, and the United Kingdom: a nationally representative observational study. 61
30200944 2018
22
Amikacin Inhalation as Salvage Therapy for Refractory Nontuberculous Mycobacterial Lung Disease. 61
29661870 2018
23
Sputum Detection of Predisposing Genetic Mutations in Women with Pulmonary Nontuberculous Mycobacterial Disease. 61
30054559 2018
24
Change in lung function in never-smokers with nontuberculous mycobacterial lung disease: A retrospective study. 61
31720386 2018
25
Nontuberculous mycobacterial lung disease in a high tuberculosis incidence setting in Brazil. 61
29791549 2018
26
Elucidating the Pathogenesis of Nontuberculous Mycobacterial Lung Disease: Lesson from the Six Blind Men and the Elephant. 61
29388833 2018
27
The outcomes of anatomical lung resection for nontuberculous mycobacterial lung disease. 61
29607168 2018
28
Changing Epidemiology of Nontuberculous Mycobacterial Lung Diseases in a Tertiary Referral Hospital in Korea between 2001 and 2015. 61
29441757 2018
29
Right extrapleural completion pneumonectomy for fibrocavitary nontuberculous mycobacterial lung disease. 61
29445484 2018
30
Nontuberculous mycobacterial lung disease in a patient with COPD and bronchiectasis, with radiological signs of lung tumor. 61
29490418 2018
31
[The Prevalence of Nontuberculous Mycobacterial Lung Disease with orwithout Reflux Esophagitis]. 61
29361809 2018
32
Endobronchial Watanabe Spigots for Treatment of Pyopneumothorax due to Nontuberculous Mycobacteriosis in a Patient with Rheumatoid Arthritis: A Case Report Based on Past Experience. 61
30356424 2018
33
Clinical significance and epidemiologic analyses of Mycobacterium avium and Mycobacterium intracellulare lung disease from post-marketing surveillance. 61
29325687 2018
34
Assessing Response to Therapy for Nontuberculous Mycobacterial Lung Disease: Quo Vadis? 61
30524407 2018
35
Effect of a 150 mg dose of rifabutin on serum itraconazole levels in patients with coexisting chronic pulmonary aspergillosis and Mycobacterium avium complex lung disease. 61
28284662 2017
36
Down-Regulation of Serum High-Mobility Group Box 1 Protein in Patients with Pulmonary Tuberculosis and Nontuberculous Mycobacterial Lung Disease. 61
28416955 2017
37
Epidemiology of Nontuberculous Mycobacterial Lung Disease and Tuberculosis, Hawaii, USA. 61
28221128 2017
38
Randomized Trial of Liposomal Amikacin for Inhalation in Nontuberculous Mycobacterial Lung Disease. 61
27748623 2017
39
Prolonged use of tedizolid in a pulmonary non-tuberculous mycobacterial infection after linezolid-induced toxicity. 61
27999019 2017
40
Causative species of nontuberculous mycobacterial lung disease and comparative investigation on clinical features of Mycobacterium abscessus complex disease: A retrospective analysis for two major hospitals in a subtropical region of Japan. 61
29059250 2017
41
A Laboratory-based Analysis of Nontuberculous Mycobacterial Lung Disease in Japan from 2012 to 2013. 61
27788025 2017
42
Characteristics associated with progression in patients with of nontuberculous mycobacterial lung disease : a prospective cohort study. 61
28056937 2017
43
Risk factors for the development of chronic pulmonary aspergillosis in patients with nontuberculous mycobacterial lung disease. 61
29190796 2017
44
Lung Function Decline According to Clinical Course in Nontuberculous Mycobacterial Lung Disease. 61
27298072 2016
45
The trend and the disease prediction of vascular endothelial growth factor and placenta growth factor in nontuberculous mycobacterial lung disease. 61
27876856 2016
46
Intractable Pneumothorax Treated With Endobronchial Watanabe Spigots. 61
27623418 2016
47
Diagnosis and Treatment of Nontuberculous Mycobacterial Lung Disease. 61
27134484 2016
48
Diagnosis and Treatment of Nontuberculous Mycobacterial Lung Disease: Clinicians' Perspectives. 61
27066084 2016
49
Regimens for nontuberculous mycobacterial lung disease lack early bactericidal activity. 61
26647433 2016
50
The antimicrobial susceptibility of non-tuberculous mycobacteria. 61
26723913 2016

Variations for Nontuberculous Mycobacterial Lung Disease

Expression for Nontuberculous Mycobacterial Lung Disease

Search GEO for disease gene expression data for Nontuberculous Mycobacterial Lung Disease.

Pathways for Nontuberculous Mycobacterial Lung Disease

Pathways related to Nontuberculous Mycobacterial Lung Disease according to GeneCards Suite gene sharing:

(show all 25)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.62 TNF IL12B HLA-DRB1 HLA-B HLA-A
2
Show member pathways
12.41 TNF TLR2 IL12B HLA-DRB1
3 12.15 TNF HLA-DRB1 HLA-B HLA-A
4
Show member pathways
12.14 TNF TLR2 IL12B HLA-DRB1 HLA-B HLA-A
5
Show member pathways
12.04 TNF TLR2 CFTR
6
Show member pathways
12.01 TNF TLR2 IL12B HLA-DRB1
7
Show member pathways
12 TNF TLR2 CFTR
8 11.96 TNF TLR2 IL12B HLA-DRB1
9 11.94 HLA-DRB1 HLA-B HLA-A
10 11.89 TNF LEP ADIPOQ
11
Show member pathways
11.87 TNF TLR2 IL12B
12
Show member pathways
11.86 TNF IL12B HLA-B HLA-A BMP6
13 11.85 TLR2 HLA-DRB1 HLA-B HLA-A
14
Show member pathways
11.81 IL12B HLA-DRB1 HLA-A
15 11.79 TNF TLR2 IL12B HLA-DRB1 HLA-B HLA-A
16 11.74 TNF TLR2 IL12B
17 11.7 TNF FBN1 BMP6
18 11.68 TNF TLR2 HLA-DRB1
19 11.54 TNF LEP ADIPOQ
20 11.43 TNF TLR2 IL12B
21 11.31 TNF TLR2 IL12B
22 11.02 LEP ADIPOQ
23 11.01 HLA-B HLA-A
24 10.96 TNF IL12B HLA-DRB1
25 10.67 TNF LEP ADIPOQ

GO Terms for Nontuberculous Mycobacterial Lung Disease

Cellular components related to Nontuberculous Mycobacterial Lung Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.91 TNF TLR2 SLC11A1 HLA-B HLA-A CFTR
2 extracellular space GO:0005615 9.87 TNF LEP IL12B HLA-B FBN1 BMP6
3 external side of plasma membrane GO:0009897 9.76 TNF IL12B HLA-DRB1 HLA-B
4 early endosome membrane GO:0031901 9.65 HLA-B HLA-A CFTR
5 recycling endosome membrane GO:0055038 9.54 HLA-B HLA-A CFTR
6 ER to Golgi transport vesicle membrane GO:0012507 9.43 HLA-DRB1 HLA-B HLA-A
7 MHC class I protein complex GO:0042612 9.4 HLA-B HLA-A
8 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.33 HLA-DRB1 HLA-B HLA-A
9 phagocytic vesicle membrane GO:0030670 9.26 TLR2 SLC11A1 HLA-B HLA-A
10 cell surface GO:0009986 9.23 TNF TLR2 IL12B HLA-DRB1 HLA-B HLA-A

Biological processes related to Nontuberculous Mycobacterial Lung Disease according to GeneCards Suite gene sharing:

(show all 33)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.93 TNF TLR2 SLC11A1 BMP6
2 inflammatory response GO:0006954 9.9 TNF TLR2 SLC11A1 BMP6
3 response to hypoxia GO:0001666 9.82 TLR2 LEP ADIPOQ
4 positive regulation of inflammatory response GO:0050729 9.75 TNF TLR2 IL12B
5 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.7 TNF LEP IL12B
6 interferon-gamma-mediated signaling pathway GO:0060333 9.69 HLA-DRB1 HLA-B HLA-A
7 response to glucocorticoid GO:0051384 9.67 TNF BMP6 ADIPOQ
8 defense response to protozoan GO:0042832 9.66 SLC11A1 IL12B
9 positive regulation of interleukin-12 production GO:0032735 9.65 TLR2 IL12B
10 positive regulation of T cell mediated cytotoxicity GO:0001916 9.65 IL12B HLA-B
11 positive regulation of interleukin-10 production GO:0032733 9.65 TLR2 IL12B
12 positive regulation of osteoclast differentiation GO:0045672 9.64 TNF IL12B
13 regulation of fat cell differentiation GO:0045598 9.63 TNF LEP
14 glucose metabolic process GO:0006006 9.63 TNF LEP ADIPOQ
15 positive regulation of chemokine production GO:0032722 9.62 TNF TLR2
16 leukocyte tethering or rolling GO:0050901 9.62 TNF LEP
17 negative regulation of phagocytosis GO:0050765 9.61 TLR2 ADIPOQ
18 negative regulation of glucose import GO:0046325 9.61 TNF LEP
19 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.61 TNF TLR2 IL12B
20 sexual reproduction GO:0019953 9.59 LEP IL12B
21 T-helper 1 type immune response GO:0042088 9.58 IL12B HLA-DRB1
22 positive regulation of tumor necrosis factor production GO:0032760 9.58 TLR2 LEP IL12B
23 multicellular organismal iron ion homeostasis GO:0060586 9.57 SLC11A1 BMP6
24 negative regulation of lipid storage GO:0010888 9.56 TNF LEP
25 positive regulation of T-helper 1 type immune response GO:0002827 9.55 SLC11A1 IL12B
26 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002480 9.54 HLA-B HLA-A
27 positive regulation of interferon-gamma production GO:0032729 9.54 TNF SLC11A1 IL12B
28 response to activity GO:0014823 9.5 LEP BMP6 ADIPOQ
29 protection from natural killer cell mediated cytotoxicity GO:0042270 9.48 HLA-B HLA-A
30 antigen processing and presentation GO:0019882 9.43 HLA-DRB1 HLA-B HLA-A
31 positive regulation of cytokine production GO:0001819 9.33 TNF SLC11A1 LEP
32 immune response GO:0006955 9.17 TNF TLR2 SLC11A1 HLA-DRB1 HLA-B HLA-A
33 positive regulation of interleukin-8 production GO:0032757 9.13 TNF TLR2 ADIPOQ

Molecular functions related to Nontuberculous Mycobacterial Lung Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.33 LEP FBN1 ADIPOQ
2 cytokine activity GO:0005125 9.26 TNF IL12B BMP6 ADIPOQ
3 peptide antigen binding GO:0042605 8.8 HLA-DRB1 HLA-B HLA-A

Sources for Nontuberculous Mycobacterial Lung Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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