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NPH
MCID: NRM002
MIFTS: 56
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Normal Pressure Hydrocephalus (NPH)
Categories:
Genetic diseases, Mental diseases, Nephrological diseases, Neuronal diseases, Rare diseases
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MalaCards integrated aliases for Normal Pressure Hydrocephalus:
Characteristics:Orphanet epidemiological data:58
normal pressure hydrocephalus
Inheritance: Not applicable; Age of onset: Adult; Classifications:
MalaCards categories:
Global: Rare diseases Genetic diseases Anatomical: Neuronal diseases Nephrological diseases Mental diseases
ICD10:
32
33
Orphanet: 58
Rare neurological diseases |
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NINDS :
53
Normal pressure hydrocephalus (NPH) is an abnormal buildup of cerebrospinal fluid (CSF) in the brain's ventricles, or cavities. It occurs if the normal flow of CSF throughout the brain and spinal cord is blocked in some way. This causes the ventricles to enlarge, putting pressure on the brain. Normal pressure hydrocephalus can occur in people of any age, but it is most common in the elderly. It may result from a subarachnoid hemorrhage, head trauma, infection, tumor, or complications of surgery. However, many people develop NPH even when none of these factors are present. In these cases the cause of the disorder is unknown.
Symptoms of NPH include progressive mental impairment and dementia, problems with walking, and impaired bladder control. The person also may have a general slowing of movements or may complain that his or her feet feel "stuck." Because these symptoms are similar to those of other disorders such as Alzheimer's disease, Parkinson's disease, and Creutzfeldt-Jakob disease, the disorder is often misdiagnosed. Many cases go unrecognized and are never properly treated. Doctors may use a variety of tests, including brain scans (CT and/or MRI), a spinal tap or lumbar catheter, intracranial pressure monitoring, and neuropsychological tests, to help them diagnose NPH and rule out other conditions.
MalaCards based summary : Normal Pressure Hydrocephalus, also known as hydrocephalus - normal pressure, is related to vascular dementia and binswanger's disease. An important gene associated with Normal Pressure Hydrocephalus is CFAP43 (Cilia And Flagella Associated Protein 43), and among its related pathways/superpathways are Neuroscience and p75(NTR)-mediated signaling. The drugs Citalopram and Serotonin Uptake Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and spinal cord, and related phenotypes are progressive gait ataxia and poor fine motor coordination KEGG : 36 Normal pressure hydrocephalus (NPH) is a progressive brain disease characterized by gait impairment, urinary incontinence, and dementia, and by ventricular enlargement in the absence of elevated intracranial pressure. NPH can be secondary to disease processes that cause inflammation of the arachnoid, such as subarachnoid hemorrhage, traumatic brain injury, or meningitis. As many as half of patients with NPH have no identifiable risk factor, and it is called idiopathic normal pressure hydrocephalus (INPH). Although INPH is usually considered an acquired form of hydrocephalus because the onset of symptoms is not until late in life, it has been reported that a subset of patients with INPH may actually have congenital hydrocephalus. Symptoms can be alleviated with a cerebrospinal fluid (CSF) shunt. Wikipedia : 74 Normal-pressure hydrocephalus (NPH), also called communicating hydrocephalus[citation needed] and... more... |
Human phenotypes related to Normal Pressure Hydrocephalus:58 31 (show all 21)
MGI Mouse Phenotypes related to Normal Pressure Hydrocephalus:45
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Drugs for Normal Pressure Hydrocephalus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):(show all 21)
Interventional clinical trials:(show top 50) (show all 51)
Cochrane evidence based reviews: hydrocephalus, normal pressure |
MalaCards organs/tissues related to Normal Pressure Hydrocephalus:40
Brain,
Testes,
Spinal Cord,
Pituitary,
Bone,
Cortex,
T Cells
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Articles related to Normal Pressure Hydrocephalus:(show top 50) (show all 2548)
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Genes related to Normal Pressure Hydrocephalus (2 elite genes):(show all 30) - Elite gene
- Cancer Census gene in COSMIC
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ClinVar genetic disease variations for Normal Pressure Hydrocephalus:6
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Search
GEO
for disease gene expression data for Normal Pressure Hydrocephalus.
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Cellular components related to Normal Pressure Hydrocephalus according to GeneCards Suite gene sharing:(show all 17)
Biological processes related to Normal Pressure Hydrocephalus according to GeneCards Suite gene sharing:(show all 28)
Molecular functions related to Normal Pressure Hydrocephalus according to GeneCards Suite gene sharing:
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