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MCID: NRM002
MIFTS: 54

Normal Pressure Hydrocephalus

Categories: Genetic diseases, Mental diseases, Nephrological diseases, Neuronal diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Normal Pressure Hydrocephalus

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MalaCards integrated aliases for Normal Pressure Hydrocephalus:

Name: Normal Pressure Hydrocephalus 12 53 36 29 6 15 17
Hydrocephalus - Normal Pressure 53
Hydrocephalus, Normal Pressure 43
Hydrocephalus Normal Pressure 54
Low Pressure Hydrocephalus 12

Classifications:

MalaCards categories:
Global: Genetic diseases
Anatomical: Neuronal diseases Nephrological diseases Mental diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:1572
KEGG 36 H01676
MeSH 43 D006850
SNOMED-CT 67 30753002
ICD10 32 G91.2
UMLS 71 C0020258
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Summaries for Normal Pressure Hydrocephalus

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NINDS : 53 Normal pressure hydrocephalus (NPH) is an abnormal buildup of cerebrospinal fluid (CSF) in the brain's ventricles, or cavities. It occurs if the normal flow of CSF throughout the brain and spinal cord is blocked in some way. This causes the ventricles to enlarge, putting pressure on the brain. Normal pressure hydrocephalus can occur in people of any age, but it is most common in the elderly. It may result from a subarachnoid hemorrhage, head trauma, infection, tumor, or complications of surgery. However, many people develop NPH even when none of these factors are present. In these cases the cause of the disorder is unknown. Symptoms of NPH include progressive mental impairment and dementia, problems with walking, and impaired bladder control. The person also may have a general slowing of movements or may complain that his or her feet feel "stuck." Because these symptoms are similar to those of other disorders such as Alzheimer's disease, Parkinson's disease, and Creutzfeldt-Jakob disease, the disorder is often misdiagnosed. Many cases go unrecognized and are never properly treated. Doctors may use a variety of tests, including brain scans (CT and/or MRI), a spinal tap or lumbar catheter, intracranial pressure monitoring, and neuropsychological tests, to help them diagnose NPH and rule out other conditions.

MalaCards based summary : Normal Pressure Hydrocephalus, also known as hydrocephalus - normal pressure, is related to vascular dementia and cerebrovascular disease. An important gene associated with Normal Pressure Hydrocephalus is CFAP43 (Cilia And Flagella Associated Protein 43), and among its related pathways/superpathways are Neuroscience and Alzheimers Disease. The drugs Citalopram and Cholinergic Agents have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and spinal cord, and related phenotypes are progressive gait ataxia and ventriculomegaly

KEGG : 36 Normal pressure hydrocephalus (NPH) is a progressive brain disease characterized by gait impairment, urinary incontinence, and dementia, and by ventricular enlargement in the absence of elevated intracranial pressure. NPH can be secondary to disease processes that cause inflammation of the arachnoid, such as subarachnoid hemorrhage, traumatic brain injury, or meningitis. As many as half of patients with NPH have no identifiable risk factor, and it is called idiopathic normal pressure hydrocephalus (INPH). Although INPH is usually considered an acquired form of hydrocephalus because the onset of symptoms is not until late in life, it has been reported that a subset of patients with INPH may actually have congenital hydrocephalus. Symptoms can be alleviated with a cerebrospinal fluid (CSF) shunt.

Wikipedia : 74 Normal-pressure hydrocephalus (NPH), also called communicating hydrocephalus[citation needed] and... more...

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Related Diseases for Normal Pressure Hydrocephalus

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Diseases in the Normal Pressure Hydrocephalus family:

Hydrocephalus, Normal-Pressure, 1

Diseases related to Normal Pressure Hydrocephalus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 315)
# Related Disease Score Top Affiliating Genes
1 vascular dementia 31.3 SERPINA3 PSEN1 MAPT APP APOE
2 cerebrovascular disease 31.2 TTR SERPINA3 MAPT APP APOE
3 binswanger's disease 31.2 VIP MAPT APP APOE
4 hydrocephalus, normal-pressure, 1 31.1 PMPCA CFAP43
5 apraxia 31.1 PSEN1 MAPT C9orf72 APOE
6 sleep apnea 31.1 HCRT BDNF APOE
7 traumatic brain injury 31.0 BDNF AQP4 APOE
8 hydrocephalus 31.0 VIP TTR SFMBT1 SERPINA3 PTGDS PSEN1
9 movement disease 30.7 SERPINA3 MAPT C9orf72
10 obsessive-compulsive disorder 30.7 NPY C9orf72 BDNF APOE
11 amnestic disorder 30.6 PSEN1 MAPT BDNF APP APOE
12 supranuclear palsy, progressive, 1 30.6 SERPINA3 PSEN1 MAPT HCRT C9orf72 APP
13 alzheimer disease 10 30.5 MAPT APOE
14 meningoencephalitis 30.5 SERPINA3 PSEN1 BDNF APP
15 frontotemporal dementia 30.5 PSEN1 NPY MAPT HCRT C9orf72 APP
16 dysgraphia 30.5 MAPT C9orf72
17 anosognosia 30.4 C9orf72 APOE
18 huntington disease 30.4 PSEN1 NPY MAPT HCRT BDNF APP
19 dementia 30.4 TTR SERPINA3 PSEN1 MAPT HCRT C9orf72
20 sleep disorder 30.3 MAPT HCRT BDNF APOE
21 communicating hydrocephalus 30.3 SFMBT1 SERPINA3 PTGDS PSEN1 MIR4274 MAPT
22 agraphia 30.3 MAPT C9orf72
23 essential tremor 30.3 MAPT C9orf72 BDNF
24 parkinson disease, late-onset 30.1 TTR SERPINA3 PSEN1 MAPT HCRT BDNF
25 alzheimer disease 30.1 TTR SERPINA3 PSEN1 NPY MAPT HCRT
26 creutzfeldt-jakob disease 30.1 SERPINA3 MAPT CLU BDNF AQP4 APP
27 cerebral amyloid angiopathy, cst3-related 30.1 TTR SERPINA3 PSEN1 MAPT CLU APP
28 peripheral nervous system disease 30.0 TTR SERPINA3 BDNF AQP4 APP
29 aphasia 29.9 PSEN1 MAPT C9orf72 BDNF APP APOE
30 amyloidosis 29.8 TTR SERPINA3 PSEN1 MAPT CLU APP
31 dementia, lewy body 29.8 SERPINA3 PSEN1 MAPT CLU C9orf72 BDNF
32 amyotrophic lateral sclerosis 1 29.6 SERPINA3 PSEN1 MAPT C9orf72 BDNF APP
33 schizophrenia 29.5 SERPINA3 NPY MAPT HCRT CLU C9orf72
34 pick disease of brain 29.4 SERPINA3 PSEN1 MAPT CLU C9orf72 BDNF
35 tremor, hereditary essential, and idiopathic normal pressure hydrocephalus 12.8
36 congenital hydrocephalus 11.5
37 hydrocephalus, congenital, 1 10.9
38 cerebral atrophy 10.6
39 residual stage of open angle glaucoma 10.6 APP APOE
40 senile plaque formation 10.6 APP APOE
41 leprosy 2 10.6 VIP NPY
42 posterior cortical atrophy 10.6 MAPT APOE
43 gerstmann syndrome 10.6 MAPT APOE
44 simultanagnosia 10.6 MAPT APOE
45 amyloid neuropathy 10.5 VIP TTR
46 chromosome 17q21.31 duplication syndrome 10.5 MAPT APP
47 alzheimer's disease 1 10.5 APP APOE
48 alzheimer disease 14 10.5 MAPT CFAP43
49 ataxia and polyneuropathy, adult-onset 10.5
50 adjustment disorder 10.5 NPY HCRT BDNF

Graphical network of the top 20 diseases related to Normal Pressure Hydrocephalus:



Diseases related to Normal Pressure Hydrocephalus
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Symptoms & Phenotypes for Normal Pressure Hydrocephalus

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Human phenotypes related to Normal Pressure Hydrocephalus:

31 (show all 18)
# Description HPO Frequency HPO Source Accession
1 progressive gait ataxia 31 hallmark (90%) HP:0007240
2 ventriculomegaly 31 frequent (33%) HP:0002119
3 weak voice 31 frequent (33%) HP:0001621
4 broad-based gait 31 frequent (33%) HP:0002136
5 dementia 31 frequent (33%) HP:0000726
6 apathy 31 frequent (33%) HP:0000741
7 poor fine motor coordination 31 frequent (33%) HP:0007010
8 urinary incontinence 31 frequent (33%) HP:0000020
9 postural instability 31 frequent (33%) HP:0002172
10 hand tremor 31 frequent (33%) HP:0002378
11 bradykinesia 31 frequent (33%) HP:0002067
12 inertia 31 frequent (33%) HP:0030216
13 shuffling gait 31 frequent (33%) HP:0002362
14 impaired visuospatial constructive cognition 31 frequent (33%) HP:0010794
15 poor gross motor coordination 31 frequent (33%) HP:0007015
16 short attention span 31 occasional (7.5%) HP:0000736
17 deficit in phonologic short-term memory 31 occasional (7.5%) HP:0002549
18 personality disorder 31 occasional (7.5%) HP:0012075

MGI Mouse Phenotypes related to Normal Pressure Hydrocephalus:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.25 APOE APP AQP4 BDNF C9orf72 CLU
2 homeostasis/metabolism MP:0005376 10.17 APOE APP AQP4 BDNF C9orf72 CLU
3 cardiovascular system MP:0005385 10.07 APOE APP AQP4 C9orf72 CLU HCRT
4 nervous system MP:0003631 10.03 APOE APP AQP4 BDNF C9orf72 CLU
5 no phenotypic analysis MP:0003012 9.76 APOE APP AQP4 BDNF C9orf72 MAPT
6 renal/urinary system MP:0005367 9.5 APOE AQP4 CLU MAPT NPY PSEN1
7 respiratory system MP:0005388 9.17 APOE AQP4 BDNF C9orf72 HCRT PSEN1
Sources

Drugs & Therapeutics for Normal Pressure Hydrocephalus

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Drugs for Normal Pressure Hydrocephalus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Citalopram Approved Phase 4 59729-33-8 2771
2 Cholinergic Agents Phase 4
3 Serotonin Receptor Agonists Phase 4
4 Muscarinic Antagonists Phase 4
5 Serotonin Uptake Inhibitors Phase 4
6 Cholinergic Antagonists Phase 4
7 Neurotransmitter Agents Phase 4
8
Serotonin Investigational, Nutraceutical Phase 4 50-67-9 5202
9
Acetazolamide Approved, Vet_approved Phase 3 59-66-5 1986
10 Flutemetamol Investigational Phase 3 637003-10-2
11 Anesthetics Phase 2, Phase 3
12 Pharmaceutical Solutions Phase 2, Phase 3
13 Anti-Infective Agents, Local Phase 2, Phase 3
14 Radiopharmaceuticals Phase 3
15 Anticonvulsants Phase 3
16 diuretics Phase 3
17 Carbonic Anhydrase Inhibitors Phase 3
18 Liver Extracts Phase 2
19 Mitogens

Interventional clinical trials:

(show top 50) (show all 54)
# Name Status NCT ID Phase Drugs
1 A Double- Blinded Comparison of the Accuracy of ShuntCheck, a Non-Invasive Device, to Radionuclide Shunt Patency Test in Evaluating Shunt Function in Patients With Adult Hydrocephalus With Possible Shunt Obstruction Completed NCT01323764 Phase 4
2 Efficacy and Safety of SSRI in Overactive Bladder Patients; a 3-month, Prospective, Open-label, Comparative Study Completed NCT00902421 Phase 4 Selective serotonin reuptake inhibitors;Antimuscarinics
3 Accuracy of ShuntCheck and MRI in Detection of Shunt Obstruction in Patients Receiving Shunt Patency Test Withdrawn NCT00793416 Phase 4
4 Scientific Research and Development of Innovative Evidence Based Non-invasive Brain Diagnostic and Monitoring Solutions for Neurological and Traumatic Brain Injury Patients Unknown status NCT02130219 Phase 2, Phase 3
5 A Principal, Open-Label, Single Center Study to Validate the Detection of Cerebral Cortical Amyloid With Flutemetamol (18F) Injection in Subjects Previously Biopsied Completed NCT01053312 Phase 3 [18F] Flutemetamol
6 A Precision and Accuracy Study of the Codman Valve Position Verification (VPV) System. Completed NCT00196196 Phase 3
7 A Principal, Prospective, Open-label Biopsy Study to Validate Detection of Cerebral Cortical Amyloid With Flutemetamol (18F) Injection in Normal Pressure Hydrocephalus (NPH) Subjects. Terminated NCT01092546 Phase 3 [18F]Flutemetamol
8 Normal Pressure Hydrocephalus Treatment by Acetazolamide Terminated NCT02163330 Phase 3 Acetazolamide;sugar pill
9 Clinical Study of Idiopathic Normal Pressure Hydrocephalus for Neurological Improvement Completed NCT00221091 Phase 2
10 Acetazolamide for Treating NPH in Shunt-candidates Patients: an Open Label Feasibility Trial Recruiting NCT03779594 Phase 2 Acetazolamide
11 Computerised Testing of Cognitive Response to Cerebrospinal Fluid Shunting in Idiopathic Normal Pressure Hydrocephalus Unknown status NCT01618500
12 The Brain Structure and Neural Network Changing the Before and After Ventriculo-peritoneal Shunting in the Normal Pressure Hydrocephalus Patients Unknown status NCT03092804
13 A Prospective Single-centre Trial Investigating Novel Parameters for the Prediction of Ventriculoperitoneal Shunting Efficacy in Patients With Idiopathic Normal Pressure Hydrocephalus Unknown status NCT02495610
14 European Multicenter Study on the Prediction of Outcome in Patients With Idiopathic Normal Pressure Hydrocephalus Unknown status NCT00874198
15 Transcranial and Rapid Magnetic Stimulation for Gait Apraxia Due to Normal Pressure Hydrocephalus and Cerebral Ischemia Unknown status NCT00494689
16 Are Intracranial Pressure Waves Measurable Through Lumbar Puncture? Completed NCT01374048
17 Evaluation of a Computerised Neuropsychological Test Battery for Idiopathic Normal Pressure Hydrocephalus (INPH) Completed NCT01265251
18 Vascular Risk Factors, Subclinical and Manifest Vascular Disease in Patients With Idiopathic Normal Pressure Hydrocephalus Completed NCT01850914
19 Normal Pressure Hydrocephalus (NPH) Registry Completed NCT00233701
20 Novel Infusion Method for Describing CSF Dynamics Completed NCT01319136
21 Predictive Value of Flow MRI in Normal Pressure Hydrocephalus Surgery Completed NCT01815775 Early Phase 1
22 Prognostic Value of Transforming Growth Factor-Beta 1 in Normal Pressure Hydrocephalus Completed NCT00600795
23 Cerebrospinal Fluid Proteome in Hydrocephalus Completed NCT02016352
24 Effects of Physical Training in Shunt-operated Patients With Idiopathic Normal Pressure Hydrocephalus Completed NCT02659111
25 A Study Comparing Shunt Placement Versus Endoscopic Third Ventriculostomy in the Treatment of Hydrocephalus Completed NCT01115270
26 Efficacy of Shunt Surgery in Normal Pressure Hydrocephalus: a Randomized Cross-over Study Completed NCT01798641
27 A Randomized Trial of High and Low Pressure Level Settings on a Programmable Ventriculoperitoneal Shunt Valve for Idiopathic Normal Pressure Hydrocephalus. Results of the Dutch Evaluation Program Strata Shunt (DEPSS) Trial Completed NCT01570257
28 VALUE OF RADIONUCLIDE CISTERNOGRAPHY IN PATIENTS WITH CEREBROSPINAL FLUID LEAK Completed NCT02876614
29 The Pathogenesis of Terson Syndrome and the Role of CSF Tau / Amyloid-ß 40 and 42 in Patients With Aneurysmatic Subarachnoid Hemorrhage Completed NCT02129010
30 Comparison of Continuous Noninvasive and Invasive Intracranial Pressure Measurement--Celda Infusion Subprotocol Completed NCT01976559
31 Diagnostic Accuracy of ShuntCheck Compared With Radionuclide Shunt Patency Test to Detect Shunt Flow Obstruction in Patients With Normal Pressure Hydrocephalus - A Cross-sectional Analytic Study Recruiting NCT04309487
32 Endoscopic Third Ventriculostomy Versus Ventriculo-peritoneal Shunting in Idiopathic Normal Pressure Hydrocephalus Recruiting NCT03245138
33 Effect of Depletive Lumbar Puncture and Cerebrospinal Fluid Shunt Surgery on Lower Urinary Tract Dysfunction in Normal Pressure Hydrocephalus Recruiting NCT03877107
34 Assessment of Cerebrospinal Fluid Flow Related Disorders Using a Phase-contrast Magnetic Resonance Imaging Technique. Recruiting NCT03656016
35 Post-Market Clinical Follow-up Registry of Patients With CODMAN CERTAS Plus Programmable Valves Recruiting NCT04207229
36 Neuropsychometric Testing With Conner's Continual Performance Test -3 in Normal Pressure Hydrocephalus Recruiting NCT03521518
37 Adjustable Gravitational vs. Adjustable Differential Pressure Valves in Patients With Idiopathic Normal Pressure Hydrocephalus. Prospective Randomized Study. Recruiting NCT04434053
38 The Effect of Hericium Erinaceus Mycelium in Non-motor Symptoms of Parkinson's Disease Recruiting NCT04428983
39 Benefit of Flow Magnetic Resonance Imaging in the Management of Normal Pressure Hydrocephalus Active, not recruiting NCT01909960
40 A Placebo-Controlled Effectiveness in INPH Shunting (PENS) Trial: Proof of Concept Active, not recruiting NCT03350750
41 Neurology Inpatient Clinical Education Trial Active, not recruiting NCT03826056
42 Magnetic Resonance Elastography in Hydrocephalus Active, not recruiting NCT02230124
43 Estimation of Intracranial Pressure Using Non-invasive Fundus Videos Active, not recruiting NCT03382860
44 Assessment of ShuntCheck Performance Characteristics in Asymptomatic Patients With Normal Pressure Hydrocephalus Enrolling by invitation NCT04011566
45 Using Cerebrospinal Fluid Dynamics to Identify Shunt Responders in Idiopathic Normal Pressure Hydrocephalus and to Optimize Postoperative Clinical Improvement While Minimizing Overdrainage Related Complications - A Double Blind Randomized Study Enrolling by invitation NCT03076723
46 Mapping Functional Networks of Brain Activity (Brain Network Activation, BNA) Based on Analysis of Evoked Response Potential (ERP) EEG Signals in Patients With Movement Disorders Not yet recruiting NCT03269201
47 Conservative Versus Surgical Management of Idiopathic Normal Pressure Hydrocephalus Terminated NCT00727142
48 Endoscopic Third Ventriculostomy (ETV) Versus Ventriculoperitoneal Shunting (VPS) for the Surgical Management of Normal Pressure Hydrocephalus Terminated NCT00946127
49 Prognostic Value of Aβ Imaging in NPH Prior to Shunt Placement Terminated NCT01834625
50 Factors Predicting Response to Shunting in Normal Pressure Hydrocephalus Terminated NCT00613886

Search NIH Clinical Center for Normal Pressure Hydrocephalus

Cochrane evidence based reviews: hydrocephalus, normal pressure

Sources

Genetic Tests for Normal Pressure Hydrocephalus

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Genetic tests related to Normal Pressure Hydrocephalus:

# Genetic test Affiliating Genes
1 Normal Pressure Hydrocephalus 29 CFAP43
Sources

Anatomical Context for Normal Pressure Hydrocephalus

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MalaCards organs/tissues related to Normal Pressure Hydrocephalus:

40
Brain, Testes, Spinal Cord, Pituitary, Cortex, Liver, Bone
Sources

Publications for Normal Pressure Hydrocephalus

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Articles related to Normal Pressure Hydrocephalus:

(show top 50) (show all 2606)
# Title Authors PMID Year
1
Quantitative analysis of transthyretin, tau and amyloid-beta in patients with dementia. 54 61
18525124 2008
2
Alzheimer's disease-related changes in diseases characterized by elevation of intracranial or intraocular pressure. 54 61
18061341 2008
3
Cerebrospinal fluid tau, phospho-tau181 and beta-amyloid1-42 in idiopathic normal pressure hydrocephalus: a discrimination from Alzheimer's disease. 54 61
17250725 2007
4
Cerebrospinal fluid orexin in aneurysmal subarachnoid haemorrhage - a pilot study. 54 61
16150596 2005
5
Immunoreactivities of amyloid beta peptide((1-42)) and total tau protein in lumbar cerebrospinal fluid of patients with normal pressure hydrocephalus. 54 61
14991454 2004
6
Lipocalin-type prostaglandin D synthase (beta-trace) in cerebrospinal fluid: a useful marker for the diagnosis of normal pressure hydrocephalus. 54 61
14630351 2003
7
[Biological markers for Alzheimer disease]. 54 61
12806899 2003
8
Shunt related changes in somatostatin, neuropeptide Y, and corticotropin releasing factor concentrations in patients with normal pressure hydrocephalus. 61 54
11181849 2001
9
Neuropeptide Y cerebrospinal fluid levels in patients with normal pressure hydrocephalus syndrome. 61 54
8080906 1994
10
Outcomes Following LSVT BIG in a Person With Idiopathic Normal Pressure Hydrocephalus: A Case Report. 61
32516302 2020
11
Intracerebral hematoma at the basal ganglia following lumbar puncture. 61
32389558 2020
12
Abdominal Insufflation Is Associated With Increase of Intracranial Pressure in Patients With Normal Pressure Hydrocephalus. 61
31620775 2020
13
Ventriculoperitoneal shunt malfunction due to chronic cholecystitis: A case report. 61
32569180 2020
14
An elderly patient with Alzheimer's disease, normal pressure hydrocephalus and traumatic brain injury: presented with behavioural symptoms similar to behavioural variant frontotemporal dementia? 61
31822154 2020
15
Role of psychiatric, cardiovascular, socioeconomic, and demographic risk factors on idiopathic normal pressure hydrocephalus: A retrospective case-control study. 61
32371292 2020
16
Aqueductal Compression by Dilated Virchow-Robin Spaces in the Mesencephalic-Pontine Region Presenting with Symptoms Mimicking Normal Pressure Hydrocephalus: A Case Report and Review of Literature. 61
32200017 2020
17
Association Between Cerebrospinal Fluid Biomarkers and Age-related Brain Changes in Patients with Normal Pressure Hydrocephalus. 61
32499567 2020
18
Prevalence of possible idiopathic normal pressure hydrocephalus in older inpatients with schizophrenia: a replication study. 61
32487126 2020
19
A venous mechanism of ventriculomegaly shared between traumatic brain injury and normal ageing. 61
32372102 2020
20
The dilemma of hydrocephalus in prolonged disorders of consciousness. 61
32484029 2020
21
Letter: Cerebrospinal Fluid Shunting Improves Long-Term Quality of Life in Idiopathic Normal Pressure Hydrocephalus. 61
32542388 2020
22
The efficacy and limitation of lumboperitoneal shunt in normal pressure hydrocephalus. 61
32155527 2020
23
Mechanisms behind altered pulsatile intracranial pressure in idiopathic normal pressure hydrocephalus: role of vascular pulsatility and systemic hemodynamic variables. 61
32533412 2020
24
Thirty-Day Hospital Readmission and Surgical Complication Rates for Shunting in Normal Pressure Hydrocephalus: A Large National Database Analysis. 61
31420654 2020
25
A new index for assessing cerebral ventricular volume in idiopathic normal-pressure hydrocephalus: a comparison with Evans' index. 61
32008047 2020
26
Ventricular Volume Is More Strongly Associated with Clinical Improvement Than the Evans Index after Shunting in Idiopathic Normal Pressure Hydrocephalus. 61
32527841 2020
27
Ventricular volumetry and free-water corrected diffusion tensor imaging of the anterior thalamic radiation in idiopathic normal pressure hydrocephalus. 61
31034894 2020
28
Biomechanical response of the CNS is associated with frailty in NPH-suspected patients. 61
31997040 2020
29
Novel, clinically applicable, method to measure step-width during the swing phase of gait. 61
32442989 2020
30
[Diagnosis and treatment of normal pressure hydrocephalus]. 61
32400383 2020
31
Commentary: Idiopathic Normal-Pressure Hydrocephalus: Diagnostic Accuracy of Automated Sulcal Morphometry in Patients With Ventriculomegaly. 61
32412589 2020
32
Prevalence of Alternative Diagnoses and Implications for Management in Idiopathic Normal Pressure Hydrocephalus Patients. 61
32472677 2020
33
ACR Appropriateness Criteria® Dementia. 61
32370954 2020
34
Creutzfeldt-Jakob Disease: A single center experience and systemic analysis of cases in Turkey. 61
32579307 2020
35
Frontal Behavior Syndromes in Idiopathic Normal Pressure Hydrocephalus as a Function of Alzheimer's Disease Biomarker Status. 61
32430087 2020
36
Neural circuits of idiopathic Normal Pressure Hydrocephalus: A perspective review of brain connectivity and symptoms meta-analysis. 61
32088348 2020
37
Progressive supranuclear palsy often develops idiopathic normal pressure hydrocephalus-like MRI features. 61
32416639 2020
38
Magnetic Resonance Imaging Biomarkers Distinguish Normal Pressure Hydrocephalus From Progressive Supranuclear Palsy. 61
32396693 2020
39
Our Efforts in Understanding Normal Pressure Hydrocephalus: Learning from the 100 Most Cited Articles by Bibliometric Analysis. 61
32059972 2020
40
Cerebral Perfusion Does Not Increase after Shunt Surgery for Normal Pressure Hydrocephalus. 61
32374437 2020
41
Progressive Parkinsonism Three Years after Shunt Surgery in a Patient with Idiopathic Normal Pressure Hydrocephalus. 61
32461527 2020
42
Commentary: Prevalence of Alternative Diagnoses and Implications for Management in Idiopathic Normal Pressure Hydrocephalus Patients. 61
32470984 2020
43
Timing of intraventricular infusion test for diagnosing idiopathic normal pressure hydrocephalus. 61
31912355 2020
44
Lumboperitoneal shunt in idiopathic normal pressure hydrocephalus: a prospective controlled study. 61
32372182 2020
45
The Utility of Serial Cerebrospinal Fluid Removal in Elderly Patients with Idiopathic Normal-Pressure Hydrocephalus? 61
32498500 2020
46
Intracranial pressure elevation alters CSF clearance pathways. 61
32299464 2020
47
Spontaneous Migration of a Ventriculoperitoneal Shunt into the Venous System: A Multidisciplinary Approach. 61
32455085 2020
48
Midbrain morphology in idiopathic normal pressure hydrocephalus: A progressive supranuclear palsy mimic. 61
31856297 2020
49
Poroelastic Mechanical Properties of the Brain Tissue of Normal Pressure Hydrocephalus Patients During Lumbar Drain Treatment Using Intrinsic Actuation MR Elastography. 61
32331966 2020
50
Anterior Callosal Angle: A New Marker of Idiopathic Normal Pressure Hydrocephalus? 61
32348895 2020
Sources

Variations for Normal Pressure Hydrocephalus

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ClinVar genetic disease variations for Normal Pressure Hydrocephalus:

6 ‎‎ ‎‎ ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 CFAP43 CFAP43, TRP1502TERSNV Pathogenic 805993
2 PMPCA NM_015160.3(PMPCA):c.1066G>A (p.Gly356Ser)SNV Pathogenic 221553 rs768643552 9:139313082-139313082 9:136418630-136418630
3 PMPCA NM_015160.3(PMPCA):c.1129G>A (p.Ala377Thr)SNV Pathogenic 221552 rs753611141 9:139313299-139313299 9:136418847-136418847
Sources

Expression for Normal Pressure Hydrocephalus

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Search GEO for disease gene expression data for Normal Pressure Hydrocephalus.
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Pathways for Normal Pressure Hydrocephalus

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Pathways related to Normal Pressure Hydrocephalus according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Neuroscience 4
11.76 VIP PSEN1 NPY MAPT HCRT CLU
2
Alzheimers Disease 1
11.63 PSEN1 MAPT APP APOE
3
p75(NTR)-mediated signaling 1
Show member pathways
 11.25 PSEN1 BDNF APP
4
Alzheimers Disease Pathway 63
10.91 PSEN1 MAPT APP APOE
Sources

GO Terms for Normal Pressure Hydrocephalus

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Cellular components related to Normal Pressure Hydrocephalus according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 cell GO:0005623 10.02 PSEN1 NPY MAPT HCRT AQP4 APP
2 dendrite GO:0030425 9.93 PSEN1 MAPT C9orf72 BDNF APOE
3 perinuclear region of cytoplasm GO:0048471 9.93 PTGDS PSEN1 HCRT CLU BDNF APP
4 neuron projection GO:0043005 9.92 VIP PSEN1 MAPT C9orf72 APP
5 extracellular space GO:0005615 9.9 TTR SERPINA3 PTGDS PMPCA NPY LRG1
6 axon GO:0030424 9.89 PSEN1 MAPT C9orf72 BDNF APP
7 cytoplasmic vesicle GO:0031410 9.87 PSEN1 NPY HCRT CLU C9orf72 BDNF
8 growth cone GO:0030426 9.71 PSEN1 MAPT C9orf72 APP
9 platelet alpha granule lumen GO:0031093 9.69 SERPINA3 CLU APP
10 synaptic vesicle GO:0008021 9.67 PSEN1 HCRT BDNF APP
11 rough endoplasmic reticulum GO:0005791 9.56 PTGDS PSEN1 HCRT APP
12 ciliary rootlet GO:0035253 9.55 PSEN1 APP
13 extracellular region GO:0005576 9.47 VIP TTR SERPINA3 PTGDS NPY MAPT
14 neurofibrillary tangle GO:0097418 9.43 MAPT CLU
15 main axon GO:0044304 9.13 MAPT C9orf72 APP

Biological processes related to Normal Pressure Hydrocephalus according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 9.92 PSEN1 MAPT APP APOE
2 cellular protein metabolic process GO:0044267 9.87 TTR PSEN1 APP APOE
3 memory GO:0007613 9.78 PSEN1 MAPT BDNF
4 neuron projection development GO:0031175 9.73 NPY MAPT APP APOE
5 synapse organization GO:0050808 9.72 PSEN1 MAPT APP
6 regulation of synaptic plasticity GO:0048167 9.7 PSEN1 MAPT BDNF
7 reverse cholesterol transport GO:0043691 9.63 CLU APOE
8 central nervous system neuron development GO:0021954 9.63 NPY MAPT
9 negative regulation of amyloid-beta formation GO:1902430 9.62 CLU APOE
10 negative regulation of long-term synaptic potentiation GO:1900272 9.61 APP APOE
11 amyloid fibril formation GO:1990000 9.6 MAPT APP
12 amyloid precursor protein metabolic process GO:0042982 9.59 PSEN1 APOE
13 neuron projection maintenance GO:1990535 9.58 PSEN1 APP
14 negative regulation of potassium ion transport GO:0043267 9.58 VIP HCRT
15 feeding behavior GO:0007631 9.58 NPY HCRT BDNF
16 modulation of age-related behavioral decline GO:0090647 9.56 PSEN1 APP
17 negative regulation of low-density lipoprotein receptor activity GO:1905598 9.54 PSEN1 APP
18 negative regulation of amyloid fibril formation GO:1905907 9.51 CLU APOE
19 microglial cell activation GO:0001774 9.5 MAPT CLU APP
20 protein import GO:0017038 9.49 CLU APOE
21 regulation of epidermal growth factor-activated receptor activity GO:0007176 9.48 PSEN1 APP
22 astrocyte activation involved in immune response GO:0002265 9.46 PSEN1 APP
23 regulation of amyloid-beta clearance GO:1900221 9.37 CLU APOE
24 astrocyte activation GO:0048143 9.33 PSEN1 MAPT APP
25 smooth endoplasmic reticulum calcium ion homeostasis GO:0051563 9.26 PSEN1 APP
26 learning or memory GO:0007611 9.26 VIP PSEN1 BDNF APP
27 positive regulation of amyloid fibril formation GO:1905908 8.92 PSEN1 CLU APP APOE

Molecular functions related to Normal Pressure Hydrocephalus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.35 NPY CLU BDNF APP APOE
2 growth factor receptor binding GO:0070851 9.26 PSEN1 APP
3 lipoprotein particle binding GO:0071813 9.16 MAPT APOE
4 neuropeptide hormone activity GO:0005184 8.8 VIP NPY HCRT
Sources

Sources for Normal Pressure Hydrocephalus

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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