MCID: NRS006
MIFTS: 20

Norse

Categories: Rare diseases, Neuronal diseases

Aliases & Classifications for Norse

MalaCards integrated aliases for Norse:

Name: Norse 53 59
New-Onset Refractory Status Epilepticus 53 59
De Novo Cryptogenic Refractory Multifocal Febrile Status Epilepticus 53
New Onset Refractory Status Epilepticus 53

Characteristics:

Orphanet epidemiological data:

59
new-onset refractory status epilepticus
Prevalence: <1/1000000 (Worldwide); Age of onset: Adult; Age of death: adult;

Classifications:

Orphanet: 59  
Rare neurological diseases


External Ids:

Orphanet 59 ORPHA363558
ICD10 via Orphanet 34 G41.8

Summaries for Norse

NIH Rare Diseases : 53 NORSE (New-Onset Refractory Status Epilepticus) is a condition characterized by the sudden onset of continuous seizures or a flurry of very frequent seizures that can not be controlled with seizure medications. In many cases people with NORSE experienced a cold or flu like illness days to weeks prior to the start of seizures. NORSE tends to affect otherwise healthy young adults, although it can affect people of any age. People with NORSE are often treated for weeks in an intensive care unit because they require prolonged anesthesia with coma-inducing drugs to control their seizures. NORSE is a life-threatening condition, with a death rate of around 30%. Survivors often have lasting brain damage and epilepsy. A minority of people with NORSE more fully recover and return to a normal lifestyle. Currently the cause of NORSE is not known.

MalaCards based summary : Norse, also known as new-onset refractory status epilepticus, is related to status epilepticus and encephalitis. An important gene associated with Norse is PAH (Phenylalanine Hydroxylase). Affiliated tissues include brain.

Related Diseases for Norse

Diseases related to Norse via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 status epilepticus 10.4
2 encephalitis 10.2
3 epilepsy 10.0
4 febrile infection-related epilepsy syndrome 10.0
5 limbic encephalitis 9.8
6 neurosyphilis 9.8
7 phenylketonuria 9.8
8 rabies 9.8
9 herpes simplex 9.8
10 herpes simplex encephalitis 9.8

Graphical network of the top 20 diseases related to Norse:



Diseases related to Norse

Symptoms & Phenotypes for Norse

Drugs & Therapeutics for Norse

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Overcoming Insomnia: Impact on Sleep, Health and Work of Online CBT-I Recruiting NCT02558647 Not Applicable

Search NIH Clinical Center for Norse

Genetic Tests for Norse

Anatomical Context for Norse

MalaCards organs/tissues related to Norse:

41
Brain

Publications for Norse

Articles related to Norse:

(show all 49)
# Title Authors Year
1
New-onset refractory status epilepticus (NORSE) and febrile infection-related epilepsy syndrome (FIRES): State of the art and perspectives. ( 29476535 )
2018
2
The NORSe: changing the way we communicate. ( 29493351 )
2018
3
Status epilepticus due to acute encephalitis: NORSE does not necessarily mean worse. ( 29938873 )
2018
4
Proposed consensus definitions for new-onset refractory status epilepticus (NORSE), febrile infection-related epilepsy syndrome (FIRES), and related conditions. ( 29399791 )
2018
5
Jamestown Canyon encephalitis with NORSE and electrographic response to ribavirin: a case report. ( 29881809 )
2018
6
Cryptogenic NORSE: Its distinctive clinical features and response to immunotherapy. ( 28959704 )
2017
7
Rabies encephalitis presenting with new-onset refractory status epilepticus (NORSE). ( 29620067 )
2017
8
New onset refractory status epilepticus due to primary angiitis of the central nervous system. ( 29062691 )
2017
9
Successful surgical management of New Onset Refractory Status Epilepticus (NORSE) presenting with gelastic seizures in a 3A year old girl. ( 28725554 )
2017
10
Plasma Exchange as a Therapeutic Modality in a Rare Case of Cryptogenic New Onset Refractory Status Epilepticus (NORSE). ( 28892919 )
2017
11
A NORSE With No Name. ( 27799856 )
2016
12
Northern exposure: Mandibular torus in the Greenlandic Norse and the whole wide world. ( 27447123 )
2016
13
New-Onset Refractory Status Epilepticus: More Investigations, More Questions. ( 27462243 )
2016
14
The lost norse. ( 27846587 )
2016
15
New-onset refractory status epilepticus: Etiology, clinical features, and outcome. ( 26296517 )
2015
16
'The great imitator': Neurosyphilis and new-onset refractory status epilepticus (NORSE) syndrome. ( 25859427 )
2015
17
New-onset refractory status epilepticus (NORSE)--The potential role for immunotherapy. ( 26010959 )
2015
18
Glacier maxima in Baffin Bay during the Medieval Warm Period coeval with Norse settlement. ( 26665173 )
2015
19
New-onset refractory status epilepticus in an adult with an atypical presentation of cat-scratch disease: successful treatment with high-dose corticosteroids. ( 26044784 )
2015
20
An Unusual Case of Triazophos Poisoning Presenting with New-Onset Refractory Status Epilepticus. ( 26862284 )
2015
21
A case of new-onset refractory status epilepticus (NORSE) with an autoimmune etiology. ( 26511026 )
2015
22
Treatment responsive GABA(B)-receptor limbic encephalitis presenting as new-onset super-refractory status epilepticus (NORSE) in a deployed U.S. soldier. ( 25465280 )
2014
23
New Onset Refractory Status Epilepticus in a Young Man with H1N1 Infection. ( 25379313 )
2014
24
New onset refractory status epilepticus as an unusual presentation of a suspected organophosphate poisoning. ( 25580311 )
2014
25
Plasma exchange in cryptogenic new onset refractory status epilepticus. ( 23068971 )
2013
26
Successful surgical treatment of an inflammatory lesion associated with new-onset refractory status epilepticus. ( 23724839 )
2013
27
New onset refractory status epilepticus (NORSE) as the heralding manifestation of herpes simplex encephalitis. ( 23887985 )
2013
28
Five cases of new onset refractory status epilepticus (NORSE) syndrome: outcomes with early immunotherapy. ( 23333762 )
2013
29
New-onset refractory status epilepticus mimicking herpes virus encephalitis. ( 24163672 )
2013
30
FIRES and NORSE are distinct entities. ( 22759241 )
2012
31
Tryggo: Old norse for truth: The real truth about ground truth: New insights into the challenges of generating ground truth maps for WSI CAD algorithm evaluation. ( 22530176 )
2012
32
Cultural adaptation, compounding vulnerabilities and conjunctures in Norse Greenland. ( 22371594 )
2012
33
NoRSE: noise reduction and state evaluator for high-frequency single event traces. ( 22088841 )
2012
34
Suicide in Old Norse and Finnish folk stories. ( 21879867 )
2011
35
AERRPS, DESC, NORSE, FIRES: multi-labeling or distinct epileptic entities? ( 22004046 )
2011
36
Two millennia of North Atlantic seasonality and implications for Norse colonies. ( 20212157 )
2010
37
New-onset refractory status epilepticus with restricted DWI and neuronophagia in the pulvinar. ( 20308685 )
2010
38
The Norse god of autophagy. Interviewed by Daniel J Klionsky. ( 20814236 )
2010
39
Cryptogenic New Onset Refractory Status Epilepticus (NORSE) in adults-Infectious or not? ( 19013586 )
2009
40
New onset refractory status epilepticus (NORSE). ( 19356770 )
2009
41
Fossil insect evidence for the end of the Western Settlement in Norse Greenland. ( 17216429 )
2007
42
Madness in the Old Norse society. Narratives and ideas. ( 17990192 )
2007
43
Comparing Norse animal husbandry practices: paleoethnobotanical analyses from Iceland and Greenland. ( 21847841 )
2007
44
Norse Greenland settlement: reflections on climate change, trade, and the contrasting fates of human settlements in the North Atlantic Islands. ( 21847839 )
2007
45
A Norse contribution to the history of neurological diseases. ( 16479124 )
2006
46
The Norse discovery of America. ( 16331154 )
2005
47
The economics of sheep and goat husbandry in Norse Greenland. ( 21774148 )
2005
48
The NORSE (new-onset refractory status epilepticus) syndrome: defining a disease entity. ( 16123813 )
2005
49
A molecular survey of phenylketonuria in Iceland: identification of a founding mutation and evidence of predominant Norse settlement. ( 9450182 )
1997

Variations for Norse

Expression for Norse

Search GEO for disease gene expression data for Norse.

Pathways for Norse

GO Terms for Norse

Sources for Norse

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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