MCID: NRW001
MIFTS: 45

Norwegian Scabies

Categories: Immune diseases, Infectious diseases, Neuronal diseases, Rare diseases, Skin diseases

Aliases & Classifications for Norwegian Scabies

MalaCards integrated aliases for Norwegian Scabies:

Name: Norwegian Scabies 12 53 15
Crusted Scabies 12 53 73
Seven Year Itch 53

Classifications:



External Ids:

Disease Ontology 12 DOID:14374
NCIt 50 C34855
SNOMED-CT 68 67172004
UMLS 73 C0028425

Summaries for Norwegian Scabies

NIH Rare Diseases : 53 Crusted scabies (also called Norwegian scabies) is a severe form of scabies that most often occurs in people who have a weakened immune system or a neurological disease, the elderly, the disabled, or those who are mentally impaired. The condition is characterized by thick crusts of skin that contain large numbers of scabies mites and eggs. The usual features of scabies (itching and a rash) may be absent. Crusted scabies is very contagious and can spread easily both by direct skin-to-skin contacts and through contaminated items such as clothing, bedding, and furniture. It is caused by superinfestation with Sarcoptes scabiei var hominis, but why the crusted scabies develops is unknown.  People with crusted scabies should receive quick and aggressive medical treatment for their infestation to prevent outbreaks of scabies.Ivermectin is commonly used for treatment.  

MalaCards based summary : Norwegian Scabies, also known as crusted scabies, is related to scabies and lupus erythematosus. An important gene associated with Norwegian Scabies is KCNE1 (Potassium Voltage-Gated Channel Subfamily E Regulatory Subunit 1), and among its related pathways/superpathways are Adipogenesis and Immune response IFN gamma signaling pathway. The drugs Permethrin and Ivermectin have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and bone, and related phenotypes are Reduced mammosphere formation and shRNA abundance <= 50%

Disease Ontology : 12 A scabies that involves infestation of human itch mite Sarcoptes scabiei type hominis in immunocompromised and elderly persons, which is characterized by vesicles and formation of thick crusts over the skin, accompanied by abundant mites but only slight itching.

Related Diseases for Norwegian Scabies

Diseases related to Norwegian Scabies via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 62)
# Related Disease Score Top Affiliating Genes
1 scabies 11.0
2 lupus erythematosus 10.3
3 leukemia 10.3
4 acquired immunodeficiency syndrome 10.3
5 systemic lupus erythematosus 10.3
6 hearing loss, noise-induced 10.2 GSTM1 KCNE1
7 paragonimiasis 10.2 IL5 MT-CO1
8 scleroderma, familial progressive 10.2
9 down syndrome 10.2
10 bullous pemphigoid 10.2
11 adult t-cell leukemia 10.2
12 t-cell leukemia 10.2
13 cercarial dermatitis 10.2 IL5 MT-CO1
14 atypical choroid plexus papilloma 10.1 NKX2-1 TWIST1
15 eosinophilia-myalgia syndrome 10.1 IL5 TGFB1
16 toxic oil syndrome 10.1 GSTM1 IL5
17 strongyloidiasis 10.1 IL5 TGFB1
18 intestinal volvulus 10.1 IL5 KCNE1 TWIST1
19 pityriasis rubra pilaris 10.1 ATP2A2 TNFRSF1B
20 rheumatoid arthritis 10.1
21 arthritis 10.1
22 herpes simplex 10.1
23 psoriasis 10.1
24 mite infestation 10.1 AADACL3 ATP2A2
25 respiratory system disease 10.1 IL5 NKX2-1 TGFB1
26 cardia cancer 10.0 GSTM1 WWOX
27 myelodysplastic syndrome 10.0
28 graft-versus-host disease 10.0
29 hepatitis 10.0
30 hepatitis b 10.0
31 liver disease 10.0
32 neutropenia 10.0
33 severe congenital neutropenia 10.0
34 immunoglobulin alpha deficiency 10.0
35 dermatomyositis 10.0
36 lepromatous leprosy 10.0
37 tinea corporis 10.0
38 astrocytoma 10.0
39 pustulosis of palm and sole 10.0
40 epidermolysis bullosa simplex 10.0
41 juvenile rheumatoid arthritis 10.0
42 chronic graft versus host disease 10.0
43 transient arthritis 10.0 TGFB1 TNFRSF1B
44 hymenolepiasis 10.0 MT-CO1 TRIM33
45 gastric cardia carcinoma 10.0 ANO1 WWOX
46 anterior scleritis 9.9 IL5 TNFRSF1B
47 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 9.9
48 asthma 9.9
49 langerhans cell histiocytosis 9.9
50 lymphoma 9.9

Graphical network of the top 20 diseases related to Norwegian Scabies:



Diseases related to Norwegian Scabies

Symptoms & Phenotypes for Norwegian Scabies

GenomeRNAi Phenotypes related to Norwegian Scabies according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.5 ATP2A2 GSTM1 HPGDS IL5 STAT1 TGFB1
2 shRNA abundance <= 50% GR00343-S 9.32 ATP2A2 HPGDS NKX2-1 NT5C STAT1 TGFB1

MGI Mouse Phenotypes related to Norwegian Scabies:

46 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.17 ANO1 ATP2A2 IL5 MT-CO1 NKX2-1 STAT1
2 behavior/neurological MP:0005386 10.16 ANO1 ATP2A2 HPGDS IL5 NKX2-1 STAT1
3 cellular MP:0005384 10.13 ATP2A2 HPGDS MT-CO1 NKX2-1 STAT1 TGFB1
4 digestive/alimentary MP:0005381 10.11 ANO1 ATP2A2 IL5 NKX2-1 STAT1 TGFB1
5 cardiovascular system MP:0005385 10.1 ANO1 ATP2A2 MT-CO1 NKX2-1 STAT1 TGFB1
6 homeostasis/metabolism MP:0005376 10.1 ANO1 ATP2A2 HPGDS IL5 MT-CO1 NKX2-1
7 immune system MP:0005387 10.02 ATP2A2 HPGDS IL5 MT-CO1 STAT1 TGFB1
8 neoplasm MP:0002006 9.91 ATP2A2 HPGDS IL5 NKX2-1 STAT1 TGFB1
9 muscle MP:0005369 9.87 ANO1 ATP2A2 MT-CO1 STAT1 TGFB1 TNFRSF1B
10 nervous system MP:0003631 9.85 ANO1 ATP2A2 HPGDS NKX2-1 STAT1 TGFB1
11 respiratory system MP:0005388 9.43 ANO1 ATP2A2 IL5 NKX2-1 TGFB1 TNFRSF1B
12 skeleton MP:0005390 9.23 ANO1 ATP2A2 NKX2-1 STAT1 TGFB1 TNFRSF1B

Drugs & Therapeutics for Norwegian Scabies

Drugs for Norwegian Scabies (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Permethrin Approved, Investigational Phase 3,Not Applicable 52645-53-1 40326
2
Ivermectin Approved, Investigational, Vet_approved Phase 3,Not Applicable 70288-86-7 6474909
3 Anti-Infective Agents Phase 3,Not Applicable
4 Antiparasitic Agents Phase 3,Not Applicable
5 Dermatologic Agents Phase 3
6 Emollients Phase 3
7
Diethylcarbamazine Approved, Investigational, Vet_approved Not Applicable 90-89-1 3052
8
Albendazole Approved, Vet_approved Not Applicable 54965-21-8 2082
9 Lipoxygenase Inhibitors Not Applicable
10 Antiprotozoal Agents Not Applicable
11 Liver Extracts Not Applicable
12 Antimitotic Agents Not Applicable
13 Anthelmintics Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficacy Study Between Two Different Dosages of an Antiparasitic in Patients With Crusted Scabies Not yet recruiting NCT02841215 Phase 3 Ivermectin 200 µg/kg;Ivermectin 400 µg/kg
2 Fiji Integrated Therapy (FIT) - Triple Therapy for Lymphatic Filariasis, Scabies and Soil Transmitted Helminths in Fiji Completed NCT03177993 Not Applicable 3 drug dose - IDA;3 drug dose - IDA with second dose of ivermectin;2 drug dose - DA

Search NIH Clinical Center for Norwegian Scabies

Genetic Tests for Norwegian Scabies

Anatomical Context for Norwegian Scabies

MalaCards organs/tissues related to Norwegian Scabies:

41
Skin, T Cells, Bone, Liver, Bone Marrow, Monocytes, Thyroid

Publications for Norwegian Scabies

Articles related to Norwegian Scabies:

(show top 50) (show all 182)
# Title Authors Year
1
Crusted (Norwegian) Scabies: Nine-Month Course With Iatrogenic Immunosuppression. ( 30365596 )
2018
2
Crusted scabies masquerading as psoriasis plaques in a patient suffering from burn scars. ( 30142723 )
2018
3
Crusted scabies in a patient with methamphetamine abuse. ( 29984289 )
2018
4
Scabies herpeticum, an emerging clinical form of crusted scabies in AIDS patient: case report and literature review. ( 30320440 )
2018
5
Noodle pattern: a new dermoscopic pattern for crusted scabies (Norwegian scabies). ( 28758268 )
2017
6
Scabies, crusted (Norwegian) scabies and the diagnosis of mite sensitisation. ( 29279260 )
2017
7
Norwegian scabies in a patient treated with Tripterygium glycoside for rheumatoid arthritis. ( 28954112 )
2017
8
Scabies herpeticum: crusted scabies with herpes simplex superinfection. ( 28166621 )
2017
9
More than a Mite Contagious: Crusted Scabies. ( 28601538 )
2017
10
Crusted scabies in northern and central Australia - now is the time for eradication. ( 28152357 )
2017
11
Misdiagnosed crusted scabies in an AIDS patient leads to hyperinfestation. ( 28398415 )
2017
12
The Brief Case: Crusted Scabies in a Leukemic Patient following a Stay in a Long-Term Acute Care Facility. ( 28442611 )
2017
13
Closing the Brief Case: Crusted Scabies in a Leukemic Patient following a Stay in a Long-Term Acute Care Facility. ( 28442617 )
2017
14
Norwegian scabies - rare case of atypical manifestation. ( 28099611 )
2016
15
Norwegian Scabies. ( 26265977 )
2015
16
Atypical presentation of crusted (Norwegian) scabies. ( 25819939 )
2015
17
Large Nosocomial Outbreak Associated with a Norwegian Scabies Index Case Undergoing TNF-I+ Inhibitor Treatment: Management and Control. ( 26288185 )
2015
18
Norwegian scabies: Rare cause of erythroderma. ( 25657922 )
2015
19
External ear canal lesions of crusted scabies: A pitfall of recurrence? ( 26134729 )
2015
20
A case of crusted scabies combined with bullous scabies. ( 26622520 )
2015
21
Crusted (Norwegian) scabies: an under-recognized infestation characterized by an atypical presentation and delayed diagnosis. ( 25428862 )
2014
22
Crusted scabies in a 15-year-old boy with congenital neutropenia and myelodysplastic syndrome. ( 24470010 )
2014
23
Crusted scabies of the scalp in a patient with systemic lupus erythematosus. ( 25526004 )
2014
24
Reflectance confocal microscopy for quantification of Sarcoptes scabiei in Norwegian scabies. ( 22621304 )
2013
25
Norwegian scabies. ( 23431220 )
2013
26
Norwegian scabies. ( 23958988 )
2013
27
Norwegian scabies mimicking rupioid psoriasis. ( 23197214 )
2012
28
Crusted scabies-associated immune reconstitution inflammatory syndrome. ( 23181485 )
2012
29
Crusted Norwegian scabies, an opportunistic infection, with tocilizumab in rheumatoid arthritis. ( 21441056 )
2011
30
Crusted (Norwegian) scabies following systemic and topical corticosteroid therapy. ( 20052371 )
2010
31
Generalized scaling and redness in a 2-month-old boy. Crusted (Norwegian) scabies (CS). ( 21182645 )
2010
32
Dermoscopy of Norwegian scabies in a patient with acquired immunodeficiency syndrome. ( 20520938 )
2010
33
Norwegian scabies in a malnourished young adult: a case report. ( 20539068 )
2010
34
Norwegian scabies in a renal transplant patient. ( 20835323 )
2010
35
Norwegian scabies associated with herpes simplex infection in a renal transplant patient. ( 19300201 )
2009
36
Images in clinical practice. Norwegian scabies presenting as erythroderma. ( 19915245 )
2009
37
Neonatal Norwegian scabies: three cooperating causes. ( 21886727 )
2009
38
Norwegian scabies in immunosuppressed patient misdiagnosed as an adverse drug reaction. ( 19750822 )
2009
39
Human T-cell lymphotrophic virus tropical paraparesis, hyperhidrosis and Norwegian scabies. ( 19747336 )
2009
40
Clinical images: Infestation by Norwegian scabies. ( 19620272 )
2009
41
Treatment of crusted scabies with albendazole: A case report. ( 19951635 )
2009
42
Atypically distributed cutaneous lesions of Norwegian scabies in an HIV-positive man in South India: a case report. ( 18341688 )
2008
43
New insights into disease pathogenesis in crusted (Norwegian) scabies: the skin immune response in crusted scabies. ( 18422789 )
2008
44
Norwegian scabies in a renal transplant patient. ( 18855794 )
2008
45
Crusted Norwegian scabies in an adult with Langerhans cell histiocytosis: mishaps leading to systemic chemotherapy. ( 17515513 )
2007
46
Norwegian scabies mimicking onychomycosis and scalp dermatitis in a child with IPEX syndrome. ( 17224384 )
2007
47
Norwegian scabies of the legs in a patient with paraplegia. ( 17239091 )
2007
48
Norwegian scabies in a healthy woman during oral cyclosporine therapy. ( 17337413 )
2007
49
A case of crusted scabies with a bullous pemphigoid-like eruption and nail involvement. ( 16620226 )
2006
50
Unusual laboratory findings in a case of Norwegian scabies provided a clue to diagnosis. ( 15872307 )
2005

Variations for Norwegian Scabies

Expression for Norwegian Scabies

Search GEO for disease gene expression data for Norwegian Scabies.

Pathways for Norwegian Scabies

Pathways related to Norwegian Scabies according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.45 STAT1 TGFB1 TWIST1
2
Show member pathways
11.27 IL5 STAT1 TGFB1 TNFRSF1B
3 10.98 STAT1 TGFB1 TNFRSF1B TWIST1
4 10.72 IL5 TGFB1

GO Terms for Norwegian Scabies

Biological processes related to Norwegian Scabies according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription by RNA polymerase II GO:0000122 9.73 NKX2-1 STAT1 TGFB1 TRIM33 TWIST1 WWOX
2 aging GO:0007568 9.67 MT-CO1 TGFB1 TNFRSF1B
3 cellular response to growth factor stimulus GO:0071363 9.5 TGFB1 TNFRSF1B TWIST1
4 endoderm development GO:0007492 9.48 NKX2-1 TGFB1
5 glutathione derivative biosynthetic process GO:1901687 9.46 GSTM1 HPGDS
6 regulation of transforming growth factor beta receptor signaling pathway GO:0017015 9.43 TGFB1 TRIM33
7 positive regulation of transcription regulatory region DNA binding GO:2000679 9.4 TGFB1 TWIST1
8 macrophage derived foam cell differentiation GO:0010742 9.37 STAT1 TGFB1
9 negative regulation of skeletal muscle tissue development GO:0048642 9.16 TGFB1 TWIST1
10 extrinsic apoptotic signaling pathway GO:0097191 9.13 TGFB1 TNFRSF1B WWOX
11 cytokine-mediated signaling pathway GO:0019221 9.02 IL5 STAT1 TGFB1 TNFRSF1B TWIST1

Molecular functions related to Norwegian Scabies according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein homodimerization activity GO:0042803 9.55 GSTM1 HPGDS STAT1 TGFB1 TWIST1
2 enzyme binding GO:0019899 9.1 ATP2A2 GSTM1 NKX2-1 STAT1 TGFB1 WWOX
3 glutathione transferase activity GO:0004364 8.96 GSTM1 HPGDS

Sources for Norwegian Scabies

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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