MCID: NRW001
MIFTS: 46

Norwegian Scabies

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Norwegian Scabies

MalaCards integrated aliases for Norwegian Scabies:

Name: Norwegian Scabies 12 53 15
Crusted Scabies 12 53 73
Seven Year Itch 53

Classifications:



External Ids:

Disease Ontology 12 DOID:14374
NCIt 50 C34855
UMLS 73 C0028425

Summaries for Norwegian Scabies

NIH Rare Diseases : 53 Crusted scabies (also called Norwegian scabies) is a severe form of scabies that most often occurs in people who have a weakened immune system or a neurological disease, the elderly, the disabled, or those who are mentally impaired. The condition is characterized by thick crusts of skin that contain large numbers of scabies mites and eggs. The usual features of scabies (itching and a rash) may be absent. Crusted scabies is very contagious and can spread easily both by direct skin-to-skin contacts and through contaminated items such as clothing, bedding, and furniture. It is caused by superinfestation with Sarcoptes scabiei var hominis, but why the crusted scabies develops is unknown.  People with crusted scabies should receive quick and aggressive medical treatment for their infestation to prevent outbreaks of scabies.Ivermectin is commonly used for treatment.  

MalaCards based summary : Norwegian Scabies, also known as crusted scabies, is related to vasculitis and rheumatoid arthritis. An important gene associated with Norwegian Scabies is KCNE1 (Potassium Voltage-Gated Channel Subfamily E Regulatory Subunit 1), and among its related pathways/superpathways are Allograft rejection and Th17 cell differentiation. The drugs Ivermectin and Permethrin have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and liver, and related phenotypes are Increased caspase activity and Increased caspase activity

Disease Ontology : 12 A scabies that involves infestation of human itch mite Sarcoptes scabiei type hominis in immunocompromised and elderly persons, which is characterized by vesicles and formation of thick crusts over the skin, accompanied by abundant mites but only slight itching.

Related Diseases for Norwegian Scabies

Diseases related to Norwegian Scabies via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 116)
# Related Disease Score Top Affiliating Genes
1 vasculitis 30.4 CD40LG CD79A TNFRSF1B
2 rheumatoid arthritis 29.4 CD40LG CD79A FOXP3 TGFB1 TNFRSF1B
3 selective igg deficiency disease 11.0 CD40LG CD79A
4 c1q nephropathy 11.0 CD40LG CD79A
5 meningovascular neurosyphilis 11.0 CD40LG CD79A
6 alpha chain disease 11.0 CD40LG CD79A
7 brill-zinsser disease 11.0 CD40LG CD79A
8 exudative glomerulonephritis 10.9 CD40LG CD79A
9 cork-handlers' disease 10.9 CD40LG CD79A
10 salpingo-oophoritis 10.9 CD40LG CD79A
11 early yaws 10.9 CD40LG CD79A
12 ventilation pneumonitis 10.9 CD40LG CD79A
13 chronic interstitial cystitis 10.9 CD40LG CD79A
14 cryofibrinogenemia 10.9 CD40LG CD79A
15 hearing loss, noise-induced 10.9 GSTM1 KCNE1
16 trichostrongyloidiasis 10.9 CD40LG CD79A
17 subacute bacterial endocarditis 10.9 CD40LG CD79A
18 heterophyiasis 10.9 CD40LG CD79A
19 immunoglobulin g deficiency 10.9 CD40LG CD79A
20 orbital granuloma 10.9 CD40LG CD79A
21 transient hypogammaglobulinemia of infancy 10.9 CD40LG CD79A
22 hyperglobulinemic purpura 10.9 CD40LG CD79A
23 gastroduodenitis 10.9 CD40LG CD79A
24 bacterial conjunctivitis 10.9 CD40LG CD79A
25 heavy chain disease 10.9 CD40LG CD79A
26 scabies 10.9
27 ophthalmia neonatorum 10.9 CD40LG CD79A
28 zika fever 10.9 CD40LG STAT1
29 immunoglobulin a deficiency 1 10.8 CD40LG CD79A
30 parotid disease 10.8 CD40LG CD79A
31 cerebral arteritis 10.8 CD40LG CD79A
32 selective immunoglobulin deficiency disease 10.8 CD40LG CD79A
33 geniculate herpes zoster 10.8 CD40LG CD79A
34 erythema elevatum diutinum 10.8 CD40LG CD79A
35 taeniasis 10.8 CD40LG CD79A MT-CO1
36 sporotrichosis 10.8 CD40LG CD79A
37 fallopian tube disease 10.7 CD40LG CD79A
38 hyperimmunoglobulin syndrome 10.7 CD40LG CD79A
39 parasitic protozoa infectious disease 10.7 CD40LG CD79A MT-CO1
40 congenital syphilis 10.7 CD40LG CD79A
41 rheumatoid lung disease 10.7 CD40LG TNFRSF1B
42 axillary adenitis 10.7 CD40LG CD79A STAT1
43 polyclonal hypergammaglobulinemia 10.7 CD40LG CD79A
44 monoclonal paraproteinemia 10.7 CD40LG CD79A
45 opportunistic mycosis 10.7 CD40LG CD79A STAT1
46 chronic meningitis 10.6 IL5 MT-CO1
47 iritis 10.6 CD40LG TNFRSF1B
48 salpingitis 10.6 CD40LG CD79A
49 conjunctival disease 10.6 CD40LG CD79A IL5
50 acute salpingitis 10.6 CD40LG CD79A TNFRSF1B

Graphical network of the top 20 diseases related to Norwegian Scabies:



Diseases related to Norwegian Scabies

Symptoms & Phenotypes for Norwegian Scabies

GenomeRNAi Phenotypes related to Norwegian Scabies according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased caspase activity GR00400-S-1 9.7 ANO1 CD79A KCNE1 NKX2-1
2 Increased caspase activity GR00400-S-2 9.7 ANO1 CD79A NKX2-1
3 Reduced mammosphere formation GR00396-S 9.56 TGFB1 TNFRSF1B ATP2A2 CD79A GSTM1 HPGDS
4 shRNA abundance <= 50% GR00343-S 9.36 STAT1 TGFB1 TNFRSF1B TRIM33 TWIST1 WWOX

MGI Mouse Phenotypes related to Norwegian Scabies:

46 (show all 16)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.31 NKX2-1 HPGDS STAT1 MT-CO1 TGFB1 TWIST1
2 homeostasis/metabolism MP:0005376 10.31 TGFB1 NKX2-1 HPGDS STAT1 IL5 MT-CO1
3 growth/size/body region MP:0005378 10.29 TGFB1 NKX2-1 STAT1 IL5 MT-CO1 TRIM33
4 behavior/neurological MP:0005386 10.26 NKX2-1 HPGDS IL5 STAT1 TGFB1 TWIST1
5 immune system MP:0005387 10.26 HPGDS STAT1 IL5 MT-CO1 TGFB1 TRIM33
6 cardiovascular system MP:0005385 10.25 TGFB1 NKX2-1 STAT1 MT-CO1 TWIST1 TNFRSF1B
7 digestive/alimentary MP:0005381 10.22 STAT1 IL5 TGFB1 NKX2-1 TWIST1 TNFRSF1B
8 mortality/aging MP:0010768 10.18 NKX2-1 HPGDS STAT1 TRIM33 TGFB1 TWIST1
9 integument MP:0010771 10.06 HPGDS STAT1 TGFB1 TNFRSF1B ATP2A2 FOXP3
10 nervous system MP:0003631 10.03 NKX2-1 HPGDS STAT1 TGFB1 TRIM33 TWIST1
11 neoplasm MP:0002006 10.02 STAT1 IL5 TGFB1 NKX2-1 TNFRSF1B WWOX
12 liver/biliary system MP:0005370 9.98 IL5 STAT1 TGFB1 WWOX TNFRSF1B FOXP3
13 muscle MP:0005369 9.91 STAT1 MT-CO1 TGFB1 TWIST1 TNFRSF1B ATP2A2
14 renal/urinary system MP:0005367 9.7 TGFB1 TNFRSF1B FOXP3 ATP2A2 CD40LG ANO1
15 respiratory system MP:0005388 9.5 NKX2-1 IL5 TGFB1 TNFRSF1B ATP2A2 FOXP3
16 skeleton MP:0005390 9.28 TGFB1 NKX2-1 STAT1 TWIST1 TNFRSF1B WWOX

Drugs & Therapeutics for Norwegian Scabies

Drugs for Norwegian Scabies (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ivermectin Approved, Investigational, Vet_approved Phase 3,Not Applicable 70288-86-7 6474909
2
Permethrin Approved, Investigational Phase 3,Not Applicable 52645-53-1 40326
3 Anti-Infective Agents Phase 3,Not Applicable
4 Antiparasitic Agents Phase 3,Not Applicable
5 Dermatologic Agents Phase 3
6 Emollients Phase 3
7
Albendazole Approved, Vet_approved Not Applicable 54965-21-8 2082
8
Diethylcarbamazine Approved, Investigational, Vet_approved Not Applicable 90-89-1 3052
9 Anthelmintics Not Applicable
10 Liver Extracts Not Applicable
11 Antiprotozoal Agents Not Applicable
12 Lipoxygenase Inhibitors Not Applicable
13 Antimitotic Agents Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficacy Study Between Two Different Dosages of an Antiparasitic in Patients With Crusted Scabies Not yet recruiting NCT02841215 Phase 3 Ivermectin 200 µg/kg;Ivermectin 400 µg/kg
2 Fiji Integrated Therapy (FIT) - Triple Therapy for Lymphatic Filariasis, Scabies and Soil Transmitted Helminths in Fiji Recruiting NCT03177993 Not Applicable 3 drug dose - IDA;3 drug dose - IDA with second dose of ivermectin;2 drug dose - DA

Search NIH Clinical Center for Norwegian Scabies

Genetic Tests for Norwegian Scabies

Anatomical Context for Norwegian Scabies

MalaCards organs/tissues related to Norwegian Scabies:

41
Skin, T Cells, Liver, Monocytes, Bone, Testes, Brain

Publications for Norwegian Scabies

Articles related to Norwegian Scabies:

(show top 50) (show all 128)
# Title Authors Year
1
Noodle pattern: a new dermoscopic pattern for crusted scabies (Norwegian scabies). ( 28758268 )
2017
2
Scabies, crusted (Norwegian) scabies and the diagnosis of mite sensitisation. ( 29279260 )
2017
3
Norwegian scabies in a patient treated with Tripterygium glycoside for rheumatoid arthritis. ( 28954112 )
2017
4
Norwegian scabies - rare case of atypical manifestation. ( 28099611 )
2016
5
Norwegian Scabies. ( 26265977 )
2015
6
Atypical presentation of crusted (Norwegian) scabies. ( 25819939 )
2015
7
Large Nosocomial Outbreak Associated with a Norwegian Scabies Index Case Undergoing TNF-I+ Inhibitor Treatment: Management and Control. ( 26288185 )
2015
8
Norwegian scabies: Rare cause of erythroderma. ( 25657922 )
2015
9
Crusted (Norwegian) scabies: an under-recognized infestation characterized by an atypical presentation and delayed diagnosis. ( 25428862 )
2014
10
Reflectance confocal microscopy for quantification of Sarcoptes scabiei in Norwegian scabies. ( 22621304 )
2013
11
Norwegian scabies. ( 23431220 )
2013
12
Norwegian scabies. ( 23958988 )
2013
13
Norwegian scabies mimicking rupioid psoriasis. ( 23197214 )
2012
14
Crusted Norwegian scabies, an opportunistic infection, with tocilizumab in rheumatoid arthritis. ( 21441056 )
2011
15
Crusted (Norwegian) scabies following systemic and topical corticosteroid therapy. ( 20052371 )
2010
16
Generalized scaling and redness in a 2-month-old boy. Crusted (Norwegian) scabies (CS). ( 21182645 )
2010
17
Dermoscopy of Norwegian scabies in a patient with acquired immunodeficiency syndrome. ( 20520938 )
2010
18
Norwegian scabies in a malnourished young adult: a case report. ( 20539068 )
2010
19
Norwegian scabies in a renal transplant patient. ( 20835323 )
2010
20
Norwegian scabies associated with herpes simplex infection in a renal transplant patient. ( 19300201 )
2009
21
Images in clinical practice. Norwegian scabies presenting as erythroderma. ( 19915245 )
2009
22
Neonatal Norwegian scabies: three cooperating causes. ( 21886727 )
2009
23
Norwegian scabies in immunosuppressed patient misdiagnosed as an adverse drug reaction. ( 19750822 )
2009
24
Human T-cell lymphotrophic virus tropical paraparesis, hyperhidrosis and Norwegian scabies. ( 19747336 )
2009
25
Clinical images: Infestation by Norwegian scabies. ( 19620272 )
2009
26
Atypically distributed cutaneous lesions of Norwegian scabies in an HIV-positive man in South India: a case report. ( 18341688 )
2008
27
New insights into disease pathogenesis in crusted (Norwegian) scabies: the skin immune response in crusted scabies. ( 18422789 )
2008
28
Norwegian scabies in a renal transplant patient. ( 18855794 )
2008
29
Crusted Norwegian scabies in an adult with Langerhans cell histiocytosis: mishaps leading to systemic chemotherapy. ( 17515513 )
2007
30
Norwegian scabies mimicking onychomycosis and scalp dermatitis in a child with IPEX syndrome. ( 17224384 )
2007
31
Norwegian scabies in a healthy woman during oral cyclosporine therapy. ( 17337413 )
2007
32
Norwegian scabies of the legs in a patient with paraplegia. ( 17239091 )
2007
33
Unusual laboratory findings in a case of Norwegian scabies provided a clue to diagnosis. ( 15872307 )
2005
34
Norwegian scabies in Peru: the impact of human T cell lymphotropic virus type I infection. ( 15964976 )
2005
35
Localised genital Norwegian scabies in an AIDS patient. ( 14755042 )
2004
36
Norwegian scabies in the immunocompromised patient. ( 15547127 )
2004
37
Norwegian scabies in an elderly patient who died after treatment with gammaBHC. ( 12729329 )
2003
38
Control of transmission of Norwegian scabies. ( 12026155 )
2002
39
Crusted (Norwegian) scabies. ( 11932093 )
2002
40
Severe and Norwegian scabies are strongly associated with retroviral (HIV-1/HTLV-1) infection in Bahia, Brazil. ( 12045498 )
2002
41
Crusted (Norwegian) scabies in leprosy. ( 11326599 )
2001
42
Lesson of the week: Norwegian scabies misdiagnosed as an adverse drug reaction. ( 10617527 )
2000
43
Crusted (Norwegian) scabies in a patient with smoldering adult T-cell leukemia. ( 11092275 )
2000
44
Crusted (Norwegian) scabies in two old-age home residents. ( 11177168 )
2000
45
Crusted (Norwegian) scabies in a patient with dystrophic epidermolysis bullosa. ( 10583180 )
1999
46
Crusted (Norwegian) scabies induced by use of topical corticosteroids and treated successfully with ivermectin. ( 10393619 )
1999
47
Dermacase. Crusted Norwegian scabies. ( 10386207 )
1999
48
Crusted (Norwegian) scabies. A simple office test demystifies the 'great imitator'. ( 10335327 )
1999
49
Norwegian scabies and a toxic shock syndrome toxin 1-producing strain of Staphylococcus aureus endocarditis in a patient with trisomy 21. ( 9770170 )
1998
50
Norwegian scabies in a patient with acquired immunodeficiency syndrome. ( 9812044 )
1998

Variations for Norwegian Scabies

Expression for Norwegian Scabies

Search GEO for disease gene expression data for Norwegian Scabies.

Pathways for Norwegian Scabies

GO Terms for Norwegian Scabies

Biological processes related to Norwegian Scabies according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.95 FOXP3 IL5 NKX2-1 STAT1 TGFB1
2 negative regulation of transcription, DNA-templated GO:0045892 9.91 FOXP3 NKX2-1 TGFB1 TRIM33 TWIST1
3 cytokine-mediated signaling pathway GO:0019221 9.65 IL5 STAT1 TGFB1 TNFRSF1B TWIST1
4 cellular response to growth factor stimulus GO:0071363 9.58 TGFB1 TNFRSF1B TWIST1
5 positive regulation of transcription regulatory region DNA binding GO:2000679 9.54 TGFB1 TWIST1
6 regulation of regulatory T cell differentiation GO:0045589 9.52 FOXP3 TGFB1
7 extrinsic apoptotic signaling pathway GO:0097191 9.5 TGFB1 TNFRSF1B WWOX
8 negative regulation of interleukin-17 production GO:0032700 9.49 FOXP3 TGFB1
9 negative regulation of histone acetylation GO:0035067 9.48 FOXP3 TWIST1
10 positive regulation of regulatory T cell differentiation GO:0045591 9.46 FOXP3 TGFB1
11 macrophage derived foam cell differentiation GO:0010742 9.43 STAT1 TGFB1
12 negative regulation of skeletal muscle tissue development GO:0048642 9.37 TGFB1 TWIST1
13 negative regulation of transcription by RNA polymerase II GO:0000122 9.17 FOXP3 NKX2-1 STAT1 TGFB1 TRIM33 TWIST1
14 regulatory T cell differentiation GO:0045066 9.16 FOXP3 TGFB1
15 tolerance induction to self antigen GO:0002513 8.96 FOXP3 TGFB1

Molecular functions related to Norwegian Scabies according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein homodimerization activity GO:0042803 9.5 CD79A FOXP3 GSTM1 HPGDS STAT1 TGFB1
2 core promoter binding GO:0001047 9.33 FOXP3 NKX2-1 STAT1
3 enzyme binding GO:0019899 9.1 ATP2A2 GSTM1 NKX2-1 STAT1 TGFB1 WWOX
4 protein binding GO:0005515 10.19 ANO1 ATP2A2 CD40LG CD79A FOXP3 GSTM1

Sources for Norwegian Scabies

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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