MCID: NRW001
MIFTS: 44

Norwegian Scabies

Categories: Immune diseases, Infectious diseases, Neuronal diseases, Rare diseases, Skin diseases

Aliases & Classifications for Norwegian Scabies

MalaCards integrated aliases for Norwegian Scabies:

Name: Norwegian Scabies 12 54 15
Crusted Scabies 12 54 74
Seven Year Itch 54

Classifications:



External Ids:

Disease Ontology 12 DOID:14374
NCIt 51 C34855
SNOMED-CT 69 67172004
UMLS 74 C0028425

Summaries for Norwegian Scabies

NIH Rare Diseases : 54 Crusted scabies (also called Norwegian scabies) is a severe form of scabies that most often occurs in people who have a weakened immune system or a neurological disease, the elderly, the disabled, or those who are mentally impaired. The condition is characterized by thick crusts of skin that contain large numbers of scabies mites and eggs. The usual features of scabies (itching and a rash) may be absent. Crusted scabies is very contagious and can spread easily both by direct skin-to-skin contacts and through contaminated items such as clothing, bedding, and furniture. It is caused by superinfestation with Sarcoptes scabiei var hominis, but why the crusted scabies develops is unknown.  People with crusted scabies should receive quick and aggressive medical treatment for their infestation to prevent outbreaks of scabies.Ivermectin is commonly used for treatment.  

MalaCards based summary : Norwegian Scabies, also known as crusted scabies, is related to scabies and lupus erythematosus. An important gene associated with Norwegian Scabies is KCNE1 (Potassium Voltage-Gated Channel Subfamily E Regulatory Subunit 1), and among its related pathways/superpathways are Pathways in cancer and Adipogenesis. The drugs Ivermectin and Permethrin have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and liver, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Disease Ontology : 12 A scabies that involves infestation of human itch mite Sarcoptes scabiei type hominis in immunocompromised and elderly persons, which is characterized by vesicles and formation of thick crusts over the skin, accompanied by abundant mites but only slight itching.

Related Diseases for Norwegian Scabies

Diseases related to Norwegian Scabies via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 79)
# Related Disease Score Top Affiliating Genes
1 scabies 11.0
2 lupus erythematosus 10.3
3 leukemia 10.3
4 acquired immunodeficiency syndrome 10.3
5 hearing loss, noise-induced 10.3 GSTM1 KCNE1
6 systemic lupus erythematosus 10.3
7 paragonimiasis 10.3 IL5 MT-CO1
8 atypical choroid plexus papilloma 10.3 NKX2-1 TWIST1
9 cercarial dermatitis 10.3 IL5 MT-CO1
10 adult t-cell leukemia 10.2
11 t-cell leukemia 10.2
12 toxic oil syndrome 10.2 GSTM1 IL5
13 scleroderma, familial progressive 10.2
14 human immunodeficiency virus type 1 10.2
15 bullous pemphigoid 10.2
16 dermatophytosis 10.2
17 eosinophilia-myalgia syndrome 10.2 IL5 TGFB1
18 strongyloidiasis 10.2 IL5 TGFB1
19 intestinal volvulus 10.1 IL5 KCNE1 TWIST1
20 anterior scleritis 10.1 IL5 TNFRSF1B
21 transient arthritis 10.1 TGFB1 TNFRSF1B
22 night blindness, congenital stationary, type 1a 10.1 IL5 MT-CO1
23 rheumatoid arthritis 10.1
24 down syndrome 10.1
25 arthritis 10.1
26 lymphoma 10.1
27 herpes simplex 10.1
28 psoriasis 10.1
29 pustulosis palmaris et plantaris 10.1 IL5 TGFB1
30 leprosy 3 10.0
31 myelodysplastic syndrome 10.0
32 graft-versus-host disease 10.0
33 burns 10.0
34 hepatitis 10.0
35 hepatitis b 10.0
36 liver disease 10.0
37 neutropenia 10.0
38 severe congenital neutropenia 10.0
39 immunoglobulin alpha deficiency 10.0
40 dermatomyositis 10.0
41 lepromatous leprosy 10.0
42 tinea corporis 10.0
43 astrocytoma 10.0
44 pustulosis of palm and sole 10.0
45 epidermolysis bullosa simplex 10.0
46 juvenile rheumatoid arthritis 10.0
47 impetigo 10.0
48 chronic graft versus host disease 10.0
49 hansen's disease 10.0
50 human t-cell leukemia virus type 1 10.0

Graphical network of the top 20 diseases related to Norwegian Scabies:



Diseases related to Norwegian Scabies

Symptoms & Phenotypes for Norwegian Scabies

GenomeRNAi Phenotypes related to Norwegian Scabies according to GeneCards Suite gene sharing:

27 (show all 26)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 10.27 TRIM33
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 10.27 TGFB1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-110 10.27 HPGDS
4 Increased shRNA abundance (Z-score > 2) GR00366-A-115 10.27 TRIM33
5 Increased shRNA abundance (Z-score > 2) GR00366-A-116 10.27 TGFB1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-120 10.27 TGFB1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-140 10.27 TGFB1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-143 10.27 TGFB1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-149 10.27 TRIM33
10 Increased shRNA abundance (Z-score > 2) GR00366-A-156 10.27 TRIM33
11 Increased shRNA abundance (Z-score > 2) GR00366-A-159 10.27 HPGDS
12 Increased shRNA abundance (Z-score > 2) GR00366-A-161 10.27 TRIM33
13 Increased shRNA abundance (Z-score > 2) GR00366-A-169 10.27 TGFB1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-178 10.27 TGFB1
15 Increased shRNA abundance (Z-score > 2) GR00366-A-19 10.27 TRIM33
16 Increased shRNA abundance (Z-score > 2) GR00366-A-198 10.27 TGFB1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-35 10.27 TGFB1
18 Increased shRNA abundance (Z-score > 2) GR00366-A-37 10.27 HPGDS
19 Increased shRNA abundance (Z-score > 2) GR00366-A-43 10.27 HPGDS
20 Increased shRNA abundance (Z-score > 2) GR00366-A-56 10.27 HPGDS TGFB1 TRIM33
21 Increased shRNA abundance (Z-score > 2) GR00366-A-7 10.27 TRIM33
22 Increased shRNA abundance (Z-score > 2) GR00366-A-83 10.27 TRIM33
23 Increased shRNA abundance (Z-score > 2) GR00366-A-85 10.27 TRIM33
24 Increased shRNA abundance (Z-score > 2) GR00366-A-88 10.27 HPGDS
25 Reduced mammosphere formation GR00396-S 9.43 GSTM1 HPGDS IL5 STAT1 TGFB1 TNFRSF1B
26 shRNA abundance <= 50% GR00343-S 9.23 HPGDS NKX2-1 NT5C STAT1 TGFB1 TNFRSF1B

MGI Mouse Phenotypes related to Norwegian Scabies:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.97 ANO1 HPGDS IL5 NKX2-1 STAT1 TGFB1
2 digestive/alimentary MP:0005381 9.92 ANO1 IL5 NKX2-1 STAT1 TGFB1 TNFRSF1B
3 growth/size/body region MP:0005378 9.91 ANO1 IL5 MT-CO1 NKX2-1 STAT1 TGFB1
4 muscle MP:0005369 9.63 ANO1 MT-CO1 STAT1 TGFB1 TNFRSF1B TWIST1
5 neoplasm MP:0002006 9.5 HPGDS IL5 NKX2-1 STAT1 TGFB1 TNFRSF1B
6 nervous system MP:0003631 9.23 ANO1 HPGDS NKX2-1 STAT1 TGFB1 TNFRSF1B

Drugs & Therapeutics for Norwegian Scabies

Drugs for Norwegian Scabies (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ivermectin Approved, Investigational, Vet_approved Phase 3,Not Applicable 70288-86-7 6474909
2
Permethrin Approved, Investigational Phase 3,Not Applicable 52645-53-1 40326
3 Antiparasitic Agents Phase 3,Not Applicable
4 Anti-Infective Agents Phase 3,Not Applicable
5 Emollients Phase 3
6 Dermatologic Agents Phase 3
7
Diethylcarbamazine Approved, Investigational, Vet_approved Not Applicable 90-89-1 3052
8
Albendazole Approved, Vet_approved Not Applicable 54965-21-8 2082
9 Antiprotozoal Agents Not Applicable
10 Liver Extracts Not Applicable
11 Lipoxygenase Inhibitors Not Applicable
12 Anthelmintics Not Applicable
13 Antimitotic Agents Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficacy Study Between Two Different Dosages of an Antiparasitic in Patients With Crusted Scabies Unknown status NCT02841215 Phase 3 Ivermectin 200 µg/kg;Ivermectin 400 µg/kg
2 Fiji Integrated Therapy (FIT) - Triple Therapy for Lymphatic Filariasis, Scabies and Soil Transmitted Helminths in Fiji Completed NCT03177993 Not Applicable 3 drug dose - IDA;3 drug dose - IDA with second dose of ivermectin;2 drug dose - DA

Search NIH Clinical Center for Norwegian Scabies

Genetic Tests for Norwegian Scabies

Anatomical Context for Norwegian Scabies

MalaCards organs/tissues related to Norwegian Scabies:

42
Skin, T Cells, Liver, Bone, Brain, Colon, Bone Marrow

Publications for Norwegian Scabies

Articles related to Norwegian Scabies:

(show top 50) (show all 253)
# Title Authors Year
1
Crusted (Norwegian) scabies as a strong marker of adult T-cell leukemia/lymphoma in HTLV-1 infection. ( 30899475 )
2019
2
Norwegian Scabies in a Patient with Down Syndrome. ( 30853199 )
2019
3
Concurrent Scabies Incognito and Crusted Scabies With Scalp Lesions Masquerading as Erythrodermic Dermatitis: Scabies Surrepticius in an Immunosuppressed Nonagenarian With Hyperkeratotic Plaques on her Head ( 30681808 )
2019
4
Norwegian scabies. ( 30849040 )
2019
5
Facial crusted scabies on renal transplant patient. ( 30718003 )
2019
6
Crusted scabies in a renal transplant recipient treated with daily ivermectin: A case report and literature review. ( 30873722 )
2019
7
Atypical crusted scabies in a patient with chronic liver disease caused by hepatitis B and D viruses. ( 29723368 )
2018
8
Treatment, prevention and public health management of impetigo, scabies, crusted scabies and fungal skin infections in endemic populations: a systematic review. ( 30582783 )
2018
9
Noodle pattern: a new dermoscopic pattern for crusted scabies (Norwegian scabies). ( 28758268 )
2018
10
Scabies, crusted (Norwegian) scabies and the diagnosis of mite sensitisation. ( 29279260 )
2018
11
Crusted (Norwegian) Scabies: Nine-Month Course With Iatrogenic Immunosuppression. ( 30365596 )
2018
12
Crusted scabies masquerading as psoriasis plaques in a patient suffering from burn scars. ( 30142723 )
2018
13
Leukocytoclastic vasculitis associated with crusted scabies. ( 29199154 )
2018
14
Clinical diagnosis of crusted scabies: Reverse focal pattern of plantar keratoderma. ( 29243244 )
2018
15
Crusted Scabies in Systemic Sclerosis with Plasma Cell Dyscrasia. ( 29854644 )
2018
16
Crusted scabies in a patient with methamphetamine abuse. ( 29984289 )
2018
17
Scabies herpeticum, an emerging clinical form of crusted scabies in AIDS patient: case report and literature review. ( 30320440 )
2018
18
Scabies herpeticum: crusted scabies with herpes simplex superinfection. ( 28166621 )
2017
19
Norwegian scabies in a patient treated with Tripterygium glycoside for rheumatoid arthritis. ( 28954112 )
2017
20
Crusted scabies due to indiscriminate use of glucocorticoid therapy in infant. ( 29186253 )
2017
21
Topical phenothrin treatment in a case of crusted scabies with nail involvement. ( 27666132 )
2017
22
Crusted scabies in northern and central Australia - now is the time for eradication. ( 28152357 )
2017
23
Misdiagnosed crusted scabies in an AIDS patient leads to hyperinfestation. ( 28398415 )
2017
24
The Brief Case: Crusted Scabies in a Leukemic Patient following a Stay in a Long-Term Acute Care Facility. ( 28442611 )
2017
25
Closing the Brief Case: Crusted Scabies in a Leukemic Patient following a Stay in a Long-Term Acute Care Facility. ( 28442617 )
2017
26
More than a Mite Contagious: Crusted Scabies. ( 28601538 )
2017
27
Crusted Scabies. ( 28767353 )
2017
28
An Itchy Problem: A Clinical Case of Crusted Scabies. ( 30755943 )
2017
29
Crusted scabies in a patient with lepromatous leprosy. ( 27183357 )
2016
30
Crusted (Norwegian) scabies: an under-recognized infestation characterized by an atypical presentation and delayed diagnosis. ( 25428862 )
2016
31
Norwegian scabies - rare case of atypical manifestation. ( 28099611 )
2016
32
Crusted Scabies: Presenting as erythroderma in a human immunodeficiency virus-seropositive patient. ( 27190417 )
2016
33
Crusted scabies in a liver transplant patient mimicking rupioid psoriasis. ( 27297820 )
2016
34
A case report of crusted scabies in an adult patient with Down syndrome. ( 26437167 )
2015
35
Norwegian scabies: Rare cause of erythroderma. ( 25657922 )
2015
36
Atypical presentation of crusted (Norwegian) scabies. ( 25819939 )
2015
37
Norwegian Scabies. ( 26265977 )
2015
38
Large Nosocomial Outbreak Associated with a Norwegian Scabies Index Case Undergoing TNF-α Inhibitor Treatment: Management and Control. ( 26288185 )
2015
39
A case of crusted scabies combined with bullous scabies. ( 26622520 )
2015
40
Treatment of crusted scabies with acitretin. ( 25781504 )
2015
41
An elderly long-term care resident with crusted scabies. ( 25798153 )
2015
42
Crusted scabies presenting as palmoplantar psoriasis in Down's syndrome. ( 25821745 )
2015
43
External ear canal lesions of crusted scabies: A pitfall of recurrence? ( 26134729 )
2015
44
Dermoscopy aids the diagnosis of crusted scabies in an erythrodermic patient. ( 26282822 )
2015
45
Crusted scabies diagnosed by reflectance confocal microscopy. ( 26515847 )
2015
46
Crusted scabies misdiagnosed as erythrodermic psoriasis in a 3-year-old girl with down syndrome. ( 24138478 )
2014
47
Crusted scabies in a 15-year-old boy with congenital neutropenia and myelodysplastic syndrome. ( 24470010 )
2014
48
Norwegian scabies. ( 23431220 )
2014
49
Norwegian crusted scabies: an unusual case presentation. ( 24370484 )
2014
50
Crusted scabies: a clinical marker of human T-lymphotropic virus type 1 infection in central Australia. ( 24938339 )
2014

Variations for Norwegian Scabies

Expression for Norwegian Scabies

Search GEO for disease gene expression data for Norwegian Scabies.

Pathways for Norwegian Scabies

Pathways related to Norwegian Scabies according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 12.35 GSTM1 IL5 STAT1 TGFB1
2 11.45 STAT1 TGFB1 TWIST1
3
Show member pathways
11.27 IL5 STAT1 TGFB1 TNFRSF1B
4 10.98 STAT1 TGFB1 TNFRSF1B TWIST1
5 10.89 IL5 TNFRSF1B
6 10.72 IL5 TGFB1

GO Terms for Norwegian Scabies

Biological processes related to Norwegian Scabies according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription, DNA-templated GO:0045892 9.8 NKX2-1 TGFB1 TRIM33 TWIST1
2 negative regulation of transcription by RNA polymerase II GO:0000122 9.77 NKX2-1 STAT1 TGFB1 TRIM33 TWIST1
3 aging GO:0007568 9.63 MT-CO1 TGFB1 TNFRSF1B
4 endoderm development GO:0007492 9.48 NKX2-1 TGFB1
5 glutathione derivative biosynthetic process GO:1901687 9.43 GSTM1 HPGDS
6 regulation of transforming growth factor beta receptor signaling pathway GO:0017015 9.4 TGFB1 TRIM33
7 cellular response to growth factor stimulus GO:0071363 9.33 TGFB1 TNFRSF1B TWIST1
8 positive regulation of transcription regulatory region DNA binding GO:2000679 9.32 TGFB1 TWIST1
9 macrophage derived foam cell differentiation GO:0010742 9.26 STAT1 TGFB1
10 cytokine-mediated signaling pathway GO:0019221 9.02 IL5 STAT1 TGFB1 TNFRSF1B TWIST1
11 negative regulation of skeletal muscle tissue development GO:0048642 8.96 TGFB1 TWIST1

Molecular functions related to Norwegian Scabies according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein homodimerization activity GO:0042803 9.35 GSTM1 HPGDS STAT1 TGFB1 TWIST1
2 glutathione transferase activity GO:0004364 9.16 GSTM1 HPGDS
3 enzyme binding GO:0019899 8.92 GSTM1 NKX2-1 STAT1 TGFB1

Sources for Norwegian Scabies

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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