MCID: NRW001
MIFTS: 38

Norwegian Scabies

Categories: Immune diseases, Infectious diseases, Rare diseases, Skin diseases

Aliases & Classifications for Norwegian Scabies

MalaCards integrated aliases for Norwegian Scabies:

Name: Norwegian Scabies 12 52 15
Crusted Scabies 12 52 71
Seven Year Itch 52

Classifications:



External Ids:

Disease Ontology 12 DOID:14374
NCIt 49 C34855
SNOMED-CT 67 67172004
UMLS 71 C0028425

Summaries for Norwegian Scabies

NIH Rare Diseases : 52 Crusted scabies (also called Norwegian scabies) is an infestation characterized by thick crusts of skin that contain large numbers of scabies mites and eggs. It is a severe form of scabies that occurs most often in people who have a weakened immune system or a neurological disease, the elderly, and the disabled. The symptoms of the more common form of scabies, such as itching and a rash, may be absent. Crusted scabies is very contagious and can spread both by direct skin-to-skin contact and through contaminated items such as clothing, bedding, and furniture. It is caused by super-infestation with Sarcoptes scabiei var hominis, a mite that can only reproduce on humans. People with crusted scabies should receive quick and aggressive medical treatment for their infestation to prevent future outbreaks of scabies. Ivermectin , a drug used to treat parasitic infections, is commonly used for treatment.

MalaCards based summary : Norwegian Scabies, also known as crusted scabies, is related to scabies and dermatophytosis. An important gene associated with Norwegian Scabies is AADACL3 (Arylacetamide Deacetylase Like 3), and among its related pathways/superpathways are PAK Pathway and Th17 cell differentiation. The drugs Dermatologic Agents and Emollients have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and lung.

Disease Ontology : 12 A scabies that involves infestation of human itch mite Sarcoptes scabiei type hominis in immunocompromised and elderly persons, which is characterized by vesicles and formation of thick crusts over the skin, accompanied by abundant mites but only slight itching.

Related Diseases for Norwegian Scabies

Diseases related to Norwegian Scabies via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 405)
# Related Disease Score Top Affiliating Genes
1 scabies 32.1 IL5 CD4 AADACL3
2 dermatophytosis 31.0 IL17A CD4
3 t-cell adult acute lymphocytic leukemia 30.5 CD8A CD4
4 exanthem 30.4 CD8A CD40LG CD4
5 allergic contact dermatitis 30.2 IL5 IL17A CD4
6 contact dermatitis 30.2 IL5 IL17A CD4
7 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 30.1 IL17A CD8A CD4
8 immunoglobulin alpha deficiency 30.0 CD8A CD40LG CD4
9 chronic mucocutaneous candidiasis 30.0 IL5 IL17A CD8A CD4
10 psoriasis 29.9 IL5 IL17A IL13 CD4
11 mite infestation 29.9 IL5 CD40LG CD4 AADACL3
12 allergic hypersensitivity disease 29.8 IL5 IL17A IL13 CD4
13 bacterial infectious disease 29.6 IL17A CD8A CD40LG CD4
14 leprosy 3 29.4 IL5 IL17A CD8A CD40LG CD4
15 autoimmune disease 29.3 IL5 IL17A IL13 CD40LG
16 systemic lupus erythematosus 29.0 IL5 IL17A IL13 CD8A CD40LG CD4
17 skin disease 28.8 IL5 IL17A IL13 CD8A CD40LG CD4
18 dermatitis, atopic 28.5 IL5 IL17A IL13 CD8A CD40LG CD4
19 acquired immunodeficiency syndrome 10.4
20 immune deficiency disease 10.4
21 bare lymphocyte syndrome, type i 10.4 CD8A CD4
22 ventilation pneumonitis 10.4 CD8A CD4
23 diffuse infiltrative lymphocytosis syndrome 10.4 CD8A CD4
24 autoimmune lymphoproliferative syndrome, type iia 10.4 CD8A CD4
25 adult t-cell leukemia 10.4
26 t-cell leukemia 10.4
27 chromosome 14q11-q22 deletion syndrome 10.4 CD8A CD4
28 diabetes mellitus, insulin-dependent, 23 10.4 CD8A CD4
29 bird fancier's lung 10.4 CD8A CD4
30 hypopyon 10.3 IL17A CD4
31 parapsoriasis 10.3 CD8A CD4
32 variola major 10.3 CD8A CD4
33 follicular mucinosis 10.3 CD8A CD4
34 spongiotic dermatitis 10.3 CD8A CD4
35 neurosarcoidosis 10.3 CD8A CD4
36 cd3zeta deficiency 10.3 CD8A CD4
37 immunodeficiency 18 10.3 CD8A CD4
38 acute interstitial pneumonia 10.3 CD8A CD4
39 silo filler's disease 10.3 IL5 IL17A
40 superficial basal cell carcinoma 10.3 CD8A CD4
41 oral tuberculosis 10.3 CD8A CD4
42 keratosis 10.3
43 dermatitis 10.3
44 oral hairy leukoplakia 10.3 CD8A CD4
45 farmer's lung 10.3 CD8A CD4
46 esophageal candidiasis 10.3 CD8A CD4
47 myeloid and lymphoid neoplasms associated with fgfr1 abnormalities 10.3 CD8A CD4
48 immunodeficiency 19 10.3 CD8A CD4
49 cardiomyopathy, familial hypertrophic, 9 10.3 CD8A CD4
50 cytokine deficiency 10.3 IL5 IL13

Graphical network of the top 20 diseases related to Norwegian Scabies:



Diseases related to Norwegian Scabies

Symptoms & Phenotypes for Norwegian Scabies

Drugs & Therapeutics for Norwegian Scabies

Drugs for Norwegian Scabies (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Dermatologic Agents Phase 3
2 Emollients Phase 3
3
Permethrin Approved, Investigational 52645-53-1 40326
4
Ivermectin Approved, Investigational, Vet_approved 70288-86-7 6474909
5
Albendazole Approved, Vet_approved 54965-21-8 2082
6
Diethylcarbamazine Approved, Investigational, Vet_approved 90-89-1 3052
7 Antiparasitic Agents
8 Anti-Infective Agents
9 Liver Extracts
10 Antimitotic Agents
11 Antiprotozoal Agents
12 Anthelmintics

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Randomized Controlled Double-blind Trial Assessing the Efficacy of a 400 ug/kg Ivermectin Regime in Patients With Crusted Scabies as Compared to a 200 ug/kg Unknown status NCT02841215 Phase 3 Ivermectin 200 µg/kg;Ivermectin 400 µg/kg
2 Community Based Safety Study of 2-drug (Diethylcarbamazine and Albendazole) Versus 3-drug (Ivermectin, Diethylcarbamazine and Albendazole) Therapy for Lymphatic Filariasis, Scabies and Soil Transmitted Helminths in Fiji Completed NCT03177993 3 drug dose - IDA;3 drug dose - IDA with second dose of ivermectin;2 drug dose - DA

Search NIH Clinical Center for Norwegian Scabies

Genetic Tests for Norwegian Scabies

Anatomical Context for Norwegian Scabies

MalaCards organs/tissues related to Norwegian Scabies:

40
Skin, T Cells, Lung, Bone, Liver, B Cells, Monocytes

Publications for Norwegian Scabies

Articles related to Norwegian Scabies:

(show top 50) (show all 467)
# Title Authors PMID Year
1
Nosocomial outbreak of crusted scabies in immunosuppressed patients caused by Sarcoptes scabiei var. canis. 61
31535362 2020
2
Scabies herpeticum, an emerging clinical form of crusted scabies in AIDS patient: case report and literature review. 61
30320440 2019
3
Crusted scabies in a Pediatric Renal transplant recipient on immunosuppressants. 61
31605666 2019
4
Norwegian scabies presenting as erythroderma in HIV: A case report. 61
31545779 2019
5
Efficacy of methotrexate as anti-inflammatory and anti-proliferative drug in dermatology: Three case reports. 61
31384322 2019
6
Scabies: A Neglected Global Disease. 61
31544694 2019
7
Management of scabies. 61
31243462 2019
8
Norwegian Scabies in a Patient with Down Syndrome. 61
30853199 2019
9
Norwegian Scabies in Two Immune-Compromised Patients: A Case Report. 61
31341862 2019
10
Crusted scabies in a renal transplant recipient treated with daily ivermectin: A case report and literature review. 61
30873722 2019
11
Facial crusted scabies on renal transplant patient. 61
30718003 2019
12
Answer to Photo Quiz: To diagnose from scratch: crusted scabies mimicking a T-cell lymphoma. 61
31502551 2019
13
To diagnose from scratch: crusted scabies mimicking a T-cell lymphoma. 61
31502550 2019
14
Treatment, prevention and public health management of impetigo, scabies, crusted scabies and fungal skin infections in endemic populations: a systematic review. 61
30582783 2019
15
A systematic review of scabies transmission models and data to evaluate the cost-effectiveness of scabies interventions. 61
30849124 2019
16
Crusted (Norwegian) scabies as a strong marker of adult T-cell leukemia/lymphoma in HTLV-1 infection. 61
30899475 2019
17
Norwegian scabies. 61
30849040 2019
18
Crusted scabies mimicking an acrodermatitis continua of Hallopeau. 61
31303653 2019
19
Norwegian Scabies management after prolonged disease course: A case report. 61
31376739 2019
20
Pruritic Crusted Scabies in an Immunocompetent Infant. 61
31772809 2019
21
Concurrent Scabies Incognito and Crusted Scabies With Scalp Lesions Masquerading as Erythrodermic Dermatitis: Scabies Surrepticius in an Immunosuppressed Nonagenarian With Hyperkeratotic Plaques on her Head 61
30681808 2019
22
Subungual and ungual scabies: avoiding severe presentation in high-risk patients. 61
30567157 2018
23
Tackling scabies: novel agents for a neglected disease. 61
29663338 2018
24
Crusted (Norwegian) Scabies: Nine-Month Course With Iatrogenic Immunosuppression. 61
30365596 2018
25
Clinical diagnosis of crusted scabies: Reverse focal pattern of plantar keratoderma. 61
29243244 2018
26
Scabies outbreaks in ten care homes for elderly people: a prospective study of clinical features, epidemiology, and treatment outcomes. 61
30068499 2018
27
Crusted scabies in a patient with methamphetamine abuse. 61
29984289 2018
28
Crusted scabies masquerading as psoriasis plaques in a patient suffering from burn scars. 61
30142723 2018
29
Novel signal transducer and activator of transcription 1 mutation disrupts small ubiquitin-related modifier conjugation causing gain of function. 61
28859974 2018
30
Scabies, crusted (Norwegian) scabies and the diagnosis of mite sensitisation. 61
29279260 2018
31
Crusted Scabies in Systemic Sclerosis with Plasma Cell Dyscrasia. 61
29854644 2018
32
Leukocytoclastic vasculitis associated with crusted scabies. 61
29199154 2018
33
Atypical crusted scabies in a patient with chronic liver disease caused by hepatitis B and D viruses. 61
29723368 2018
34
[Norwegian Scabies]. 61
30130486 2018
35
Noodle pattern: a new dermoscopic pattern for crusted scabies (Norwegian scabies). 61
28758268 2018
36
A Case Report of Real-Time in vivo Demonstration of Sarcoptes scabiei. 61
29318996 2017
37
Norwegian or Crusted Sarcoptic Mange in Two Leishmanial Dogs. 61
28892427 2017
38
More than a Mite Contagious: Crusted Scabies. 61
28601538 2017
39
Crusted scabies 61
30512770 2017
40
Crusted Scabies. 61
28767353 2017
41
European guideline for the management of scabies. 61
28639722 2017
42
Host immune responses to the itch mite, Sarcoptes scabiei, in humans. 61
28797273 2017
43
Norwegian scabies in a patient treated with Tripterygium glycoside for rheumatoid arthritis. 61
28954112 2017
44
Scabies outbreak among healthcare workers in a German acute care hospital. 61
28989526 2017
45
The Brief Case: Crusted Scabies in a Leukemic Patient following a Stay in a Long-Term Acute Care Facility. 61
28442611 2017
46
Closing the Brief Case: Crusted Scabies in a Leukemic Patient following a Stay in a Long-Term Acute Care Facility. 61
28442617 2017
47
[Scabies of the nail unit in an infant]. 61
28063594 2017
48
Crusted scabies due to indiscriminate use of glucocorticoid therapy in infant. 61
29186253 2017
49
Topical phenothrin treatment in a case of crusted scabies with nail involvement. 61
27666132 2017
50
Scabies herpeticum: crusted scabies with herpes simplex superinfection. 61
28166621 2017

Variations for Norwegian Scabies

Expression for Norwegian Scabies

Search GEO for disease gene expression data for Norwegian Scabies.

Pathways for Norwegian Scabies

Pathways related to Norwegian Scabies according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.03 IL5 IL17A IL13 CD40LG CD4
2
Show member pathways
12.32 IL5 IL17A IL13 CD4
3
Show member pathways
12.17 IL5 IL17A IL13 CD8A CD40LG CD4
4
Show member pathways
12.1 IL5 IL17A CD8A CD40LG CD4
5 11.87 CD8A CD40LG CD4
6 11.74 IL5 CD8A CD4
7 11.63 IL5 CD8A CD4
8 11.24 IL5 IL13 CD4
9 11.12 CD8A CD40LG CD4
10 11 IL13 CD4
11 11 IL5 IL17A IL13
12 10.95 IL5 IL13
13 10.92 IL5 IL17A IL13 CD8A CD4
14 10.9 IL5 IL13 CD4
15 10.75 IL5 IL17A IL13 CD40LG
16 10.66 UGT2B7 UGT1A9
17 10.39 UGT2B7 UGT1A9

GO Terms for Norwegian Scabies

Cellular components related to Norwegian Scabies according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.02 IL17A IL13 CD8A CD40LG CD4

Biological processes related to Norwegian Scabies according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.46 CD40LG IL13 IL17A IL5
2 cellular glucuronidation GO:0052695 9.26 UGT1A9 UGT2B7
3 cytokine-mediated signaling pathway GO:0019221 9.26 CD4 IL13 IL17A IL5
4 immune response GO:0006955 9.17 IL5 IL17A IL13 CD8A CD40LG CD4

Molecular functions related to Norwegian Scabies according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 glucuronosyltransferase activity GO:0015020 9.16 UGT2B7 UGT1A9
2 retinoic acid binding GO:0001972 8.96 UGT2B7 UGT1A9
3 cytokine activity GO:0005125 8.92 IL5 IL17A IL13 CD40LG

Sources for Norwegian Scabies

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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