Aliases & Classifications for Nosophobia

MalaCards integrated aliases for Nosophobia:

Name: Nosophobia 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060048

Summaries for Nosophobia

Disease Ontology : 12 A specific phobia that involves an irrational fear of contracting a disease.

MalaCards based summary : Nosophobia is related to breast medullary carcinoma and papillary serous adenocarcinoma. An important gene associated with Nosophobia is MCIDAS (Multiciliate Differentiation And DNA Synthesis Associated Cell Cycle Protein), and among its related pathways/superpathways are Homologous DNA Pairing and Strand Exchange and Cell cycle Role of SCF complex in cell cycle regulation. The drugs Antibodies and Immunoglobulins have been mentioned in the context of this disorder. Affiliated tissues include heart and thyroid, and related phenotypes are Decreased homologous recombination repair frequency and Decreased homologous recombination repair frequency

Wikipedia : 76 Nosophobia is the irrational fear of contracting a disease, a type of specific phobia. Primary fears of... more...

Related Diseases for Nosophobia

Diseases related to Nosophobia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 44)
# Related Disease Score Top Affiliating Genes
1 breast medullary carcinoma 10.0 BRCA1 PGR
2 papillary serous adenocarcinoma 10.0 BRCA1 PGR
3 anxiety 9.9
4 hypochondriasis 9.9
5 estrogen-receptor negative breast cancer 9.9 BRCA1 PGR
6 in situ carcinoma 9.9 BRCA1 PGR
7 breast ductal carcinoma 9.7 BRCA1 PGR
8 hereditary site-specific ovarian cancer syndrome 9.7 BRCA1 BRCA2
9 breast reconstruction 9.7 BRCA1 BRCA2
10 tuberculous salpingitis 9.7 BRCA1 BRCA2
11 uterine corpus serous adenocarcinoma 9.6 BRCA1 BRCA2
12 breast-ovarian cancer, familial 1 9.6 BRCA1 BRCA2
13 fallopian tube adenocarcinoma 9.6 BRCA1 BRCA2
14 peritoneum cancer 9.6 BRCA1 BRCA2
15 premature menopause 9.6 BRCA1 BRCA2
16 clear cell adenofibroma 9.6 BRCA1 BRCA2
17 cystadenofibroma 9.6 BRCA1 BRCA2
18 lynch syndrome i 9.6 BRCA1 BRCA2
19 mutagen sensitivity 9.6 BRCA1 BRCA2
20 ovarian cancer 1 9.5 BRCA1 BRCA2
21 hereditary breast ovarian cancer syndrome 9.5 BRCA1 BRCA2
22 cowden disease 9.4 BRCA1 BRCA2
23 li-fraumeni syndrome 9.4 BRCA1 BRCA2
24 lynch syndrome 9.2 BRCA1 BRCA2
25 wilms tumor 1 9.2 BRCA2 PGR
26 synchronous bilateral breast carcinoma 9.1 BRCA1 BRCA2 PGR
27 glycogen-rich clear cell breast carcinoma 9.1 BRCA1 BRCA2 PGR
28 dysgerminoma of ovary 9.1 BRCA1 BRCA2 PGR
29 bilateral breast cancer 9.1 BRCA1 BRCA2 PGR
30 primary peritoneal carcinoma 9.1 BRCA1 BRCA2 PGR
31 pre-malignant neoplasm 9.1 BRCA1 BRCA2 PGR
32 fallopian tube carcinoma 9.1 BRCA1 BRCA2 PGR
33 malignant ovarian surface epithelial-stromal neoplasm 9.1 BRCA1 BRCA2 PGR
34 ovary epithelial cancer 9.1 BRCA1 BRCA2 PGR
35 breast carcinoma in situ 9.1 BRCA1 BRCA2 PGR
36 female breast cancer 9.1 BRCA1 BRCA2 PGR
37 sporadic breast cancer 9.1 BRCA1 BRCA2 PGR
38 ductal carcinoma in situ 9.1 BRCA1 BRCA2 PGR
39 female reproductive organ cancer 9.1 BRCA1 BRCA2 PGR
40 adamantinoma of long bones 9.0 BRCA1 BRCA2 PGR
41 fanconi anemia, complementation group a 8.9 BRCA1 BRCA2
42 endometrial cancer 8.8 BRCA1 BRCA2 PGR
43 ovarian cancer 8.7 BRCA1 BRCA2 PGR
44 cancerophobia 8.5 BRCA1 BRCA2 MCIDAS PGR

Graphical network of the top 20 diseases related to Nosophobia:



Diseases related to Nosophobia

Symptoms & Phenotypes for Nosophobia

GenomeRNAi Phenotypes related to Nosophobia according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased homologous recombination repair frequency GR00151-A-1 10.4 BRCA1
2 Decreased homologous recombination repair frequency GR00151-A-2 10.4 BRCA1
3 Decreased homologous recombination repair frequency GR00236-A-1 10.4 BRCA2 PGR BRCA1
4 Decreased homologous recombination repair frequency GR00236-A-2 10.4 BRCA2 PGR BRCA1
5 Decreased homologous recombination repair frequency GR00236-A-3 10.4 BRCA2 BRCA1
6 Decreased viability after ionizing radiation GR00232-A-2 9.16 BRCA1 BRCA2
7 Decreased viability with cisplatin GR00101-A-4 8.96 BRCA1 BRCA2
8 Synthetic lethal with cisplatin GR00101-A-1 8.62 BRCA1 BRCA2

MGI Mouse Phenotypes related to Nosophobia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 limbs/digits/tail MP:0005371 9.13 BRCA1 BRCA2 PGR
2 neoplasm MP:0002006 8.8 BRCA1 BRCA2 PGR

Drugs & Therapeutics for Nosophobia

Drugs for Nosophobia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antibodies
2 Immunoglobulins

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Tool to Assess Psycho-Social-Spiritual Healing: Cognitive Interviewing Completed NCT02664402
2 Cognitively-Based Compassion Training for Breast Cancer Survivors Recruiting NCT03305952 Not Applicable
3 Deciding on Active Surveillance or Surgery for Primary Management of Low Risk Papillary Thyroid Cancer Recruiting NCT03271892
4 Retinoblastoma Survivor Study: Assessment of General Health and Quality of Life Active, not recruiting NCT00639301
5 Literacy and Smoking Risk Communications Active, not recruiting NCT00684437 Not Applicable
6 Treatment Alternatives in iSGS (NoAAC PR-02 Study) Active, not recruiting NCT02481817
7 Trial to Reduce Inappropriate Oesophagogastroduodenoscopies for Dyspepsia Enrolling by invitation NCT03205319 Not Applicable

Search NIH Clinical Center for Nosophobia

Genetic Tests for Nosophobia

Anatomical Context for Nosophobia

MalaCards organs/tissues related to Nosophobia:

41
Heart, Thyroid

Publications for Nosophobia

Articles related to Nosophobia:

# Title Authors Year
1
NOSOPHOBIA AND HYPOCHONDRIASIS IN MEDICAL STUDENTS. ( 14206454 )
1964
2
Fear, anxiety and cardiac nosophobia (cardiac neurosis) associated with electrocardiographic T wave directional changes. ( 13657210 )
1959
3
Nosophobia. ( 18866779 )
1948

Variations for Nosophobia

Expression for Nosophobia

Search GEO for disease gene expression data for Nosophobia.

Pathways for Nosophobia

GO Terms for Nosophobia

Cellular components related to Nosophobia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lateral element GO:0000800 8.62 BRCA1 BRCA2

Biological processes related to Nosophobia according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 regulation of transcription, DNA-templated GO:0006355 9.78 BRCA1 BRCA2 MCIDAS PGR
2 positive regulation of transcription by RNA polymerase II GO:0045944 9.67 BRCA1 MCIDAS PGR
3 cell cycle GO:0007049 9.61 BRCA1 BRCA2 MCIDAS
4 DNA recombination GO:0006310 9.46 BRCA1 BRCA2
5 double-strand break repair via homologous recombination GO:0000724 9.4 BRCA1 BRCA2
6 double-strand break repair GO:0006302 9.37 BRCA1 BRCA2
7 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.32 BRCA1 BRCA2
8 DNA synthesis involved in DNA repair GO:0000731 9.26 BRCA1 BRCA2
9 strand displacement GO:0000732 9.16 BRCA1 BRCA2
10 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 8.96 BRCA1 BRCA2
11 chordate embryonic development GO:0043009 8.62 BRCA1 BRCA2

Molecular functions related to Nosophobia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 8.8 BRCA2 MCIDAS PGR

Sources for Nosophobia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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