Nosophobia disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Nosophobia

MalaCards integrated aliases for Nosophobia:

Name: Nosophobia ¹² ¹⁵

Classifications:

MalaCards categories:
Anatomical: Mental diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0060048

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Summaries for Nosophobia

Disease Ontology : ¹² A specific phobia that involves an irrational fear of contracting a disease.

MalaCards based summary : Nosophobia is related to anxiety and hypochondriasis. An important gene associated with Nosophobia is MCIDAS (Multiciliate Differentiation And DNA Synthesis Associated Cell Cycle Protein), and among its related pathways/superpathways are Homologous DNA Pairing and Strand Exchange and Cell cycle Role of SCF complex in cell cycle regulation. The drugs Antibodies and Immunoglobulins have been mentioned in the context of this disorder. Affiliated tissues include heart, bone and ovary, and related phenotypes are Decreased homologous recombination repair frequency and Decreased homologous recombination repair frequency

Wikipedia : ⁷⁶ Nosophobia is the irrational fear of contracting a disease, a type of specific phobia. Primary fears of... more...

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Related Diseases for Nosophobia

Diseases related to Nosophobia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 49)

#	Related Disease	Score	Top Affiliating Genes
1	anxiety	10.1
2	hypochondriasis	10.1
3	breast medullary carcinoma	10.0	BRCA1 PGR
4	papillary serous adenocarcinoma	10.0	BRCA1 PGR
5	uterine corpus cancer	10.0	BRCA1 PGR
6	in situ carcinoma	10.0	BRCA1 PGR
7	estrogen-receptor negative breast cancer	10.0	BRCA1 PGR
8	hereditary site-specific ovarian cancer syndrome	9.9	BRCA1 BRCA2
9	breast reconstruction	9.9	BRCA1 BRCA2
10	tuberculous salpingitis	9.9	BRCA1 BRCA2
11	breast ductal carcinoma	9.9	BRCA1 PGR
12	breast-ovarian cancer, familial 1	9.9	BRCA1 BRCA2
13	fallopian tube adenocarcinoma	9.9	BRCA1 BRCA2
14	premature menopause	9.9	BRCA1 BRCA2
15	peritoneum cancer	9.9	BRCA1 BRCA2
16	fallopian tube disease	9.9	BRCA1 BRCA2
17	lynch syndrome	9.9	BRCA1 BRCA2
18	lynch syndrome i	9.9	BRCA1 BRCA2
19	mutagen sensitivity	9.9	BRCA1 BRCA2
20	fanconi anemia, complementation group q	9.9	BRCA1 BRCA2
21	ovarian cancer 1	9.8	BRCA1 BRCA2
22	hereditary breast ovarian cancer syndrome	9.8	BRCA1 BRCA2
23	gonadal disease	9.8	BRCA1 BRCA2
24	cowden disease	9.8	BRCA1 BRCA2
25	li-fraumeni syndrome	9.8	BRCA1 BRCA2
26	endocrine gland cancer	9.8	BRCA1 BRCA2
27	synchronous bilateral breast carcinoma	9.7	BRCA1 BRCA2 PGR
28	glycogen-rich clear cell breast carcinoma	9.7	BRCA1 BRCA2 PGR
29	bilateral breast cancer	9.7	BRCA1 BRCA2 PGR
30	primary peritoneal carcinoma	9.7	BRCA1 BRCA2 PGR
31	pre-malignant neoplasm	9.7	BRCA1 BRCA2 PGR
32	fallopian tube carcinoma	9.7	BRCA1 BRCA2 PGR
33	dysgerminoma of ovary	9.7	BRCA1 BRCA2 PGR
34	breast carcinoma in situ	9.7	BRCA1 BRCA2 PGR
35	malignant ovarian surface epithelial-stromal neoplasm	9.7	BRCA1 BRCA2 PGR
36	pancreas adenocarcinoma	9.7	BRCA1 BRCA2
37	ovary epithelial cancer	9.7	BRCA1 BRCA2 PGR
38	female breast cancer	9.7	BRCA1 BRCA2 PGR
39	ovarian cancer	9.7	BRCA1 BRCA2 PGR
40	sporadic breast cancer	9.7	BRCA1 BRCA2 PGR
41	ductal carcinoma in situ	9.7	BRCA1 BRCA2 PGR
42	female reproductive system disease	9.7	BRCA1 BRCA2 PGR
43	reproductive system disease	9.7	BRCA1 BRCA2 PGR
44	ovarian disease	9.7	BRCA1 BRCA2 PGR
45	breast disease	9.7	BRCA1 BRCA2 PGR
46	adamantinoma of long bones	9.7	BRCA1 BRCA2 PGR
47	fanconi anemia, complementation group a	9.6	BRCA1 BRCA2
48	endometrial cancer	9.6	BRCA1 BRCA2 PGR
49	cancerophobia	9.5	BRCA1 BRCA2 MCIDAS PGR

Graphical network of the top 20 diseases related to Nosophobia:

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Symptoms & Phenotypes for Nosophobia

GenomeRNAi Phenotypes related to Nosophobia according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased homologous recombination repair frequency	GR00151-A-1	10.4	BRCA1
2	Decreased homologous recombination repair frequency	GR00151-A-2	10.4	BRCA1
3	Decreased homologous recombination repair frequency	GR00236-A-1	10.4	BRCA1 BRCA2 PGR
4	Decreased homologous recombination repair frequency	GR00236-A-2	10.4	BRCA1 BRCA2 PGR
5	Decreased homologous recombination repair frequency	GR00236-A-3	10.4	BRCA1 BRCA2
6	Decreased viability after ionizing radiation	GR00232-A-2	9.16	BRCA1 BRCA2
7	Decreased viability with cisplatin	GR00101-A-4	8.96	BRCA1 BRCA2
8	Synthetic lethal with cisplatin	GR00101-A-1	8.62	BRCA1 BRCA2

MGI Mouse Phenotypes related to Nosophobia:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	limbs/digits/tail	MP:0005371	9.13	BRCA1 BRCA2 PGR
2	neoplasm	MP:0002006	8.8	BRCA1 BRCA2 PGR

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Drugs & Therapeutics for Nosophobia

Drugs for Nosophobia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

#	Name	Status	Phase	Clinical Trials	Cas Number	PubChem Id
1	Antibodies
2	Immunoglobulins

Interventional clinical trials:

#	Name	Status	NCT ID	Phase
1	Tool to Assess Psycho-Social-Spiritual Healing: Cognitive Interviewing	Completed	NCT02664402
2	Cognitively-Based Compassion Training for Breast Cancer Survivors	Recruiting	NCT03305952	Not Applicable
3	Deciding on Active Surveillance or Surgery for Primary Management of Low Risk Papillary Thyroid Cancer	Recruiting	NCT03271892
4	Retinoblastoma Survivor Study: Assessment of General Health and Quality of Life	Active, not recruiting	NCT00639301
5	Literacy and Smoking Risk Communications	Active, not recruiting	NCT00684437	Not Applicable
6	Treatment Alternatives in iSGS (NoAAC PR-02 Study)	Active, not recruiting	NCT02481817
7	Trial to Reduce Inappropriate Oesophagogastroduodenoscopies for Dyspepsia	Enrolling by invitation	NCT03205319	Not Applicable

Search NIH Clinical Center for Nosophobia

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Genetic Tests for Nosophobia

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Anatomical Context for Nosophobia

MalaCards organs/tissues related to Nosophobia:

⁴¹

Heart, Bone, Ovary, Pancreas

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Publications for Nosophobia

Articles related to Nosophobia:

#	Title	Authors	Year
1	NOSOPHOBIA AND HYPOCHONDRIASIS IN MEDICAL STUDENTS. ( 14206454 )	HUNTER R.C....SCHWARTZMAN A.E.	1964
2	Fear, anxiety and cardiac nosophobia (cardiac neurosis) associated with electrocardiographic T wave directional changes. ( 13657210 )		1959
3	Nosophobia. ( 18866779 )	RYLE J.A.	1948

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Genes for Nosophobia

Genes related to Nosophobia (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	MCIDAS	Multiciliate Differentiation And DNA Synthesis Associated Cell Cycle Protein	Protein Coding	16.43	DISEASES inferred ¹⁵
2	BRCA1	BRCA1, DNA Repair Associated	Protein Coding	14.66	DISEASES inferred ¹⁵
3	BRCA2	BRCA2, DNA Repair Associated	Protein Coding	13.91	DISEASES inferred ¹⁵
4	PGR	Progesterone Receptor	Protein Coding	13.71	DISEASES inferred ¹⁵

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Variations for Nosophobia

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Expression for Nosophobia

Search GEO for disease gene expression data for Nosophobia.

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Pathways for Nosophobia

Pathways related to Nosophobia according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Homologous DNA Pairing and Strand Exchange ⁶⁶ Show member pathways ATR Signaling ¹ HDR through Homologous Recombination (HRR) ⁶⁶ HDR through Single Strand Annealing (SSA) ⁶⁶ Presynaptic phase of homologous DNA pairing and strand exchange ⁶⁶	11.73	BRCA1 BRCA2
2	Cell cycle Role of SCF complex in cell cycle regulation ²² Show member pathways Cell cycle ESR1 regulation of G1/S transition ²² Cell cycle Regulation of G1/S transition (part 1) ²² Immune response MIF-JAB1 signaling ²²	11.61	BRCA1 PGR
3	Integrated Breast Cancer Pathway ¹	11.51	BRCA1 BRCA2
4	Gastric cancer ³⁷ Show member pathways Breast cancer ³⁷ Hepatocellular carcinoma ³⁷	11.47	BRCA1 BRCA2 PGR
5	Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) ⁶⁶ Show member pathways Homologous recombination ³⁷ Homologous recombination ¹ Resolution of D-Loop Structures ⁶⁶ Resolution of D-loop Structures through Holliday Junction Intermediates ⁶⁶	11.44	BRCA1 BRCA2
6	Fanconi anemia pathway ³⁷ ⁶⁶	11.13	BRCA1 BRCA2
7	DNA damage_Role of Brca1 and Brca2 in DNA repair ²²	11.01	BRCA1 BRCA2
8	BRCA1 Pathway ⁶⁴ Show member pathways Fanconi's Anaemia Pathway ⁶⁴	10.87	BRCA1 BRCA2

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GO Terms for Nosophobia

Cellular components related to Nosophobia according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	lateral element	GO:0000800	8.62	BRCA1 BRCA2

Biological processes related to Nosophobia according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of transcription by RNA polymerase II	GO:0045944	9.63	BRCA1 MCIDAS PGR
2	cell cycle	GO:0007049	9.54	BRCA1 BRCA2 MCIDAS
3	DNA recombination	GO:0006310	9.43	BRCA1 BRCA2
4	double-strand break repair via homologous recombination	GO:0000724	9.4	BRCA1 BRCA2
5	double-strand break repair	GO:0006302	9.32	BRCA1 BRCA2
6	intrinsic apoptotic signaling pathway in response to DNA damage	GO:0008630	9.26	BRCA1 BRCA2
7	mammary gland development	GO:0030879	9.16	BRCA2 PGR
8	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	GO:0006978	8.96	BRCA1 BRCA2
9	chordate embryonic development	GO:0043009	8.62	BRCA1 BRCA2

Molecular functions related to Nosophobia according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	identical protein binding	GO:0042802	8.92	BRCA1 BRCA2 MCIDAS PGR

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Sources for Nosophobia

¹ BioSystems

² BitterDB

³ CDC

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¹⁶ DrugBank

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¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

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³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

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⁴⁶ MGI

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⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia