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MCID: NSP004
MIFTS: 30

Nosophobia

Categories: Mental diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Nosophobia

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MalaCards integrated aliases for Nosophobia:

Name: Nosophobia 12 15 17

Classifications:

MalaCards categories:
Anatomical: Mental diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:0060048
Sources

Summaries for Nosophobia

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Disease Ontology : 12 A specific phobia that involves an irrational fear of contracting a disease.

MalaCards based summary : Nosophobia is related to anxiety and hypochondriasis. An important gene associated with Nosophobia is MCIDAS (Multiciliate Differentiation And DNA Synthesis Associated Cell Cycle Protein), and among its related pathways/superpathways are Homologous DNA Pairing and Strand Exchange and Cell cycle Role of SCF complex in cell cycle regulation. The drugs Antibodies and Immunoglobulins have been mentioned in the context of this disorder. Affiliated tissues include heart, breast and thyroid, and related phenotypes are Decreased homologous recombination repair frequency and Decreased homologous recombination repair frequency

Wikipedia : 77 Nosophobia is the irrational fear of contracting a disease, a type of specific phobia. Primary fears of... more...

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Related Diseases for Nosophobia

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Diseases related to Nosophobia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 48)
# Related Disease Score Top Affiliating Genes
1 anxiety 10.1
2 hypochondriasis 10.1
3 breast medullary carcinoma 10.0 BRCA1 PGR
4 papillary serous adenocarcinoma 10.0 BRCA1 PGR
5 uterine corpus cancer 10.0 BRCA1 PGR
6 in situ carcinoma 9.9 BRCA1 PGR
7 estrogen-receptor negative breast cancer 9.9 BRCA1 PGR
8 hereditary site-specific ovarian cancer syndrome 9.8 BRCA1 BRCA2
9 tuberculous salpingitis 9.8 BRCA1 BRCA2
10 breast reconstruction 9.8 BRCA1 BRCA2
11 breast ductal carcinoma 9.8 BRCA1 PGR
12 breast-ovarian cancer, familial 1 9.8 BRCA1 BRCA2
13 fallopian tube adenocarcinoma 9.8 BRCA1 BRCA2
14 premature menopause 9.8 BRCA1 BRCA2
15 peritoneum cancer 9.8 BRCA1 BRCA2
16 fallopian tube disease 9.8 BRCA1 BRCA2
17 lynch syndrome 9.8 BRCA1 BRCA2
18 lynch syndrome i 9.8 BRCA1 BRCA2
19 mutagen sensitivity 9.8 BRCA1 BRCA2
20 fanconi anemia, complementation group q 9.8 BRCA1 BRCA2
21 ovarian cancer 1 9.7 BRCA1 BRCA2
22 hereditary breast ovarian cancer syndrome 9.7 BRCA1 BRCA2
23 gonadal disease 9.7 BRCA1 BRCA2
24 li-fraumeni syndrome 9.7 BRCA1 BRCA2
25 endocrine gland cancer 9.6 BRCA1 BRCA2
26 synchronous bilateral breast carcinoma 9.6 BRCA1 BRCA2 PGR
27 glycogen-rich clear cell breast carcinoma 9.6 BRCA1 BRCA2 PGR
28 bilateral breast cancer 9.6 BRCA1 BRCA2 PGR
29 primary peritoneal carcinoma 9.6 BRCA1 BRCA2 PGR
30 pre-malignant neoplasm 9.6 BRCA1 BRCA2 PGR
31 fallopian tube carcinoma 9.6 BRCA1 BRCA2 PGR
32 dysgerminoma of ovary 9.6 BRCA1 BRCA2 PGR
33 breast carcinoma in situ 9.6 BRCA1 BRCA2 PGR
34 pancreas adenocarcinoma 9.6 BRCA1 BRCA2
35 malignant ovarian surface epithelial-stromal neoplasm 9.6 BRCA1 BRCA2 PGR
36 ovary epithelial cancer 9.6 BRCA1 BRCA2 PGR
37 female breast cancer 9.5 BRCA1 BRCA2 PGR
38 ovarian cancer 9.5 BRCA1 BRCA2 PGR
39 sporadic breast cancer 9.5 BRCA1 BRCA2 PGR
40 ductal carcinoma in situ 9.5 BRCA1 BRCA2 PGR
41 female reproductive system disease 9.5 BRCA1 BRCA2 PGR
42 reproductive system disease 9.5 BRCA1 BRCA2 PGR
43 ovarian disease 9.5 BRCA1 BRCA2 PGR
44 breast disease 9.5 BRCA1 BRCA2 PGR
45 adamantinoma of long bones 9.5 BRCA1 BRCA2 PGR
46 fanconi anemia, complementation group a 9.4 BRCA1 BRCA2
47 endometrial cancer 9.4 BRCA1 BRCA2 PGR
48 cancerophobia 9.3 BRCA1 BRCA2 MCIDAS PGR

Graphical network of the top 20 diseases related to Nosophobia:



Diseases related to Nosophobia
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Symptoms & Phenotypes for Nosophobia

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GenomeRNAi Phenotypes related to Nosophobia according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased homologous recombination repair frequency GR00151-A-1 10.4 BRCA1
2 Decreased homologous recombination repair frequency GR00151-A-2 10.4 BRCA1
3 Decreased homologous recombination repair frequency GR00236-A-1 10.4 BRCA1 BRCA2 PGR
4 Decreased homologous recombination repair frequency GR00236-A-2 10.4 BRCA1 BRCA2 PGR
5 Decreased homologous recombination repair frequency GR00236-A-3 10.4 BRCA1 BRCA2
6 Decreased viability after ionizing radiation GR00232-A-2 9.16 BRCA1 BRCA2
7 Decreased viability with cisplatin GR00101-A-4 8.96 BRCA1 BRCA2
8 Synthetic lethal with cisplatin GR00101-A-1 8.62 BRCA1 BRCA2

MGI Mouse Phenotypes related to Nosophobia:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 limbs/digits/tail MP:0005371 9.13 BRCA1 BRCA2 PGR
2 neoplasm MP:0002006 8.8 BRCA1 BRCA2 PGR
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Drugs & Therapeutics for Nosophobia

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Drugs for Nosophobia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antibodies
2 Immunoglobulins

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Cognitively-Based Compassion Training for Breast Cancer Survivors Recruiting NCT03305952 Not Applicable
2 Trial to Reduce Inappropriate Oesophagogastroduodenoscopies for Dyspepsia Enrolling by invitation NCT03205319 Not Applicable
3 Retinoblastoma Survivor Study: Assessment of General Health and Quality of Life Active, not recruiting NCT00639301
4 Tool to Assess Psycho-Social-Spiritual Healing: Cognitive Interviewing Completed NCT02664402
5 Literacy and Smoking Risk Communications Active, not recruiting NCT00684437 Not Applicable
6 Deciding on Active Surveillance or Surgery for Primary Management of Low Risk Papillary Thyroid Cancer Recruiting NCT03271892
7 Treatment Alternatives in iSGS (NoAAC PR-02 Study) Active, not recruiting NCT02481817

Search NIH Clinical Center for Nosophobia

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Genetic Tests for Nosophobia

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Anatomical Context for Nosophobia

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MalaCards organs/tissues related to Nosophobia:

42
Heart, Breast, Thyroid
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Publications for Nosophobia

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Articles related to Nosophobia:

# Title Authors Year
1
NOSOPHOBIA AND HYPOCHONDRIASIS IN MEDICAL STUDENTS. ( 14206454 )
1964
2
Fear, anxiety and cardiac nosophobia (cardiac neurosis) associated with electrocardiographic T wave directional changes. ( 13657210 )
1959
3
Nosophobia. ( 18866779 )
1948
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Variations for Nosophobia

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Expression for Nosophobia

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Search GEO for disease gene expression data for Nosophobia.
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Pathways for Nosophobia

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Pathways related to Nosophobia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Homologous DNA Pairing and Strand Exchange 67
Show member pathways
 11.73 BRCA1 BRCA2
2
Cell cycle Role of SCF complex in cell cycle regulation 23
Show member pathways
 11.61 BRCA1 PGR
3
Integrated Breast Cancer Pathway 1
11.51 BRCA1 BRCA2
4
Gastric cancer 38
Show member pathways
 11.47 BRCA1 BRCA2 PGR
5
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 67
Show member pathways
 11.44 BRCA1 BRCA2
6
Fanconi anemia pathway 67 38
11.13 BRCA1 BRCA2
7
DNA damage_Role of Brca1 and Brca2 in DNA repair 23
11.01 BRCA1 BRCA2
8
BRCA1 Pathway 65
Show member pathways
 10.87 BRCA1 BRCA2
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GO Terms for Nosophobia

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Cellular components related to Nosophobia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lateral element GO:0000800 8.62 BRCA1 BRCA2

Biological processes related to Nosophobia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.63 BRCA1 MCIDAS PGR
2 cell cycle GO:0007049 9.54 BRCA1 BRCA2 MCIDAS
3 DNA recombination GO:0006310 9.43 BRCA1 BRCA2
4 double-strand break repair via homologous recombination GO:0000724 9.4 BRCA1 BRCA2
5 double-strand break repair GO:0006302 9.32 BRCA1 BRCA2
6 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.26 BRCA1 BRCA2
7 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 8.96 BRCA1 BRCA2
8 mammary gland development GO:0030879 8.85 PGR
9 chordate embryonic development GO:0043009 8.62 BRCA1 BRCA2

Molecular functions related to Nosophobia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 8.92 BRCA1 BRCA2 MCIDAS PGR
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Sources for Nosophobia

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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