Nosophobia disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Nosophobia

MalaCards integrated aliases for Nosophobia:

Name: Nosophobia ¹² ¹⁵ ¹⁷

Classifications:

MalaCards categories:
Anatomical: Mental diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0060048

EFO ¹⁷ EFO_1001903

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Summaries for Nosophobia

Disease Ontology : ¹² A specific phobia that involves an irrational fear of contracting a disease.

MalaCards based summary : Nosophobia is related to hypochondriasis and neurotic disorder. An important gene associated with Nosophobia is MCIDAS (Multiciliate Differentiation And DNA Synthesis Associated Cell Cycle Protein), and among its related pathways/superpathways is BRCA1 Pathway. Affiliated tissues include breast, heart and ovary, and related phenotypes are Negative genetic interaction between KRASG13D/+ and KRAS+/- and Decreased viability with cisplatin

Wikipedia : ⁷⁴ Nosophobia is the irrational fear of contracting a disease, a type of specific phobia. Primary fears of... more...

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Related Diseases for Nosophobia

Diseases related to Nosophobia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 43)

#	Related Disease	Score	Top Affiliating Genes
1	hypochondriasis	10.2
2	neurotic disorder	10.2
3	hereditary site-specific ovarian cancer syndrome	10.1	BRCA2 BRCA1
4	rare malignant breast tumor	10.1	BRCA2 BRCA1
5	synchronous bilateral breast carcinoma	10.1	BRCA2 BRCA1
6	breast juvenile papillomatosis	10.1	BRCA2 BRCA1
7	familial ovarian cancer	10.1	BRCA2 BRCA1
8	tetraploidy	10.1	BRCA2 BRCA1
9	breast-ovarian cancer, familial 2	10.1	BRCA2 BRCA1
10	endosalpingiosis	10.1	BRCA2 BRCA1
11	breast-ovarian cancer, familial 1	10.1	BRCA2 BRCA1
12	mutagen sensitivity	10.1	BRCA2 BRCA1
13	primary peritoneal carcinoma	10.1	BRCA2 BRCA1
14	intracystic papillary adenoma	10.1	BRCA2 BRCA1
15	hypertrophy of breast	10.1	BRCA2 BRCA1
16	dysplastic nevus syndrome	10.1	BRCA2 BRCA1
17	peritoneum cancer	10.1	BRCA2 BRCA1
18	female reproductive endometrioid cancer	10.1	BRCA2 BRCA1
19	premature menopause	10.1	BRCA2 BRCA1
20	papillary serous adenocarcinoma	10.1	BRCA2 BRCA1
21	fallopian tube disease	10.1	BRCA2 BRCA1
22	lobular neoplasia	10.1	BRCA2 BRCA1
23	thoracic benign neoplasm	10.1	BRCA2 BRCA1
24	breast benign neoplasm	10.1	BRCA2 BRCA1
25	fanconi anemia, complementation group d1	10.1	BRCA2 BRCA1
26	myasthenic syndrome, congenital, 6, presynaptic	10.1	BRCA2 BRCA1
27	fanconi anemia, complementation group j	10.0	BRCA2 BRCA1
28	bilateral breast cancer	10.0	BRCA2 BRCA1
29	uterine corpus cancer	10.0	BRCA2 BRCA1
30	ovarian cystadenocarcinoma	10.0	BRCA2 BRCA1
31	papillary adenocarcinoma	10.0	BRCA2 BRCA1
32	dysgerminoma	10.0	BRCA2 BRCA1
33	fallopian tube carcinoma	10.0	BRCA2 BRCA1
34	congenital hypoplastic anemia	10.0	BRCA2 BRCA1
35	female breast cancer	10.0	BRCA2 BRCA1
36	pre-malignant neoplasm	9.9	BRCA2 BRCA1
37	sporadic breast cancer	9.9	BRCA2 BRCA1
38	serous cystadenocarcinoma	9.9	BRCA2 BRCA1
39	in situ carcinoma	9.9	BRCA2 BRCA1
40	ovary adenocarcinoma	9.8	BRCA2 BRCA1
41	breast carcinoma in situ	9.7	BRCA2 BRCA1
42	bloom syndrome	9.6	BRCA2 BRCA1
43	cancerophobia	8.3	SFTA3 SCN2B POGLUT1 MCIDAS MAPK8IP1 BRCA2

Graphical network of the top 20 diseases related to Nosophobia:

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Symptoms & Phenotypes for Nosophobia

GenomeRNAi Phenotypes related to Nosophobia according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Negative genetic interaction between KRASG13D/+ and KRAS+/-	GR00255-A-5	9.26	BRCA1 BRCA2 EXOC1 MAPK8IP1
2	Decreased viability with cisplatin	GR00101-A-4	9.16	BRCA1 BRCA2
3	Synthetic lethal with cisplatin	GR00101-A-1	8.62	BRCA1 BRCA2

MGI Mouse Phenotypes related to Nosophobia:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	nervous system	MP:0003631	9.1	BRCA1 BRCA2 MAPK8IP1 MCIDAS POGLUT1 SCN2B

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Drugs & Therapeutics for Nosophobia

Search Clinical Trials , NIH Clinical Center for Nosophobia

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Genetic Tests for Nosophobia

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Anatomical Context for Nosophobia

MalaCards organs/tissues related to Nosophobia:

⁴⁰

Breast, Heart, Ovary

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Publications for Nosophobia

Articles related to Nosophobia:

(show all 12)

#	Title	Authors	PMID	Year
1	Illness behavior. ⁶¹	Sirri L...Grandi S	22056904	2012
2	[Anxiety, depression, panic disorder and bronchial asthma]. ⁶¹	Vashadze Sh	22201083	2011
3	Psychosomatic characterization of adjustment disorders in the medical setting: some suggestions for DSM-V. ⁶¹	Grassi L...Sonino N	17196662	2007
4	[Thanatophobia in the patients on dialysis]. ⁶¹	Novakovic M...Gajic M	16683410	2006
5	[Management of chronic headache]. ⁶¹	Henry P...Creac'h C	11139742	2000
6	PET study and neuropsychological assessment of a long-lasting post-encephalitic parkinsonism. ⁶¹	Caparros-Lefebvre D...Petit H	9720976	1998
7	A tentative classification of "neuroses" based on behavioristic consideration of the pathogenetic mechanisms. ⁶¹	Maeda H	8201788	1993
8	[Therapeutic neglect omission of individual treatment of secondary defective developments]. ⁶¹	Leonhard K	549047	1979
9	[Relationship between the unconscious and motivation in establishing a therapeutic program]. ⁶¹	Seidel K...Kulawik H	652866	1978
10	NOSOPHOBIA AND HYPOCHONDRIASIS IN MEDICAL STUDENTS. ⁶¹	HUNTER RC...SCHWARTZMAN AE	14206454	1964
11	Fear, anxiety and cardiac nosophobia (cardiac neurosis) associated with electrocardiographic T wave directional changes. ⁶¹	TORTORA AR	13657210	1959
12	Nosophobia. ⁶¹	RYLE JA	18866779	1948

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Genes for Nosophobia

Genes related to Nosophobia (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	MCIDAS	Multiciliate Differentiation And DNA Synthesis Associated Cell Cycle Protein	Protein Coding	5.78	DISEASES inferred ¹⁵
2	BRCA1	BRCA1 DNA Repair Associated	Protein Coding	4.94	DISEASES inferred ¹⁵
3	SFTA3	Surfactant Associated 3	RNA Gene	4.83	DISEASES inferred ¹⁵
4	MAPK8IP1	Mitogen-Activated Protein Kinase 8 Interacting Protein 1	Protein Coding	4.83	DISEASES inferred ¹⁵
5	POGLUT1	Protein O-Glucosyltransferase 1	Protein Coding	4.83	DISEASES inferred ¹⁵
6	SCN2B	Sodium Voltage-Gated Channel Beta Subunit 2	Protein Coding	4.75	DISEASES inferred ¹⁵
7	EXOC1	Exocyst Complex Component 1	Protein Coding	4.72	DISEASES inferred ¹⁵
8	BRCA2	BRCA2 DNA Repair Associated	Protein Coding	4.72	DISEASES inferred ¹⁵

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Variations for Nosophobia

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Expression for Nosophobia

Search GEO for disease gene expression data for Nosophobia.

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Pathways for Nosophobia

Pathways related to Nosophobia according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	BRCA1 Pathway ⁶³ Show member pathways Fanconi's Anaemia Pathway ⁶³	10.54	BRCA2 BRCA1

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GO Terms for Nosophobia

Cellular components related to Nosophobia according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	lateral element	GO:0000800	8.62	BRCA2 BRCA1

Biological processes related to Nosophobia according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	double-strand break repair	GO:0006302	9.26	BRCA2 BRCA1
2	intrinsic apoptotic signaling pathway in response to DNA damage	GO:0008630	9.16	BRCA2 BRCA1
3	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	GO:0006978	8.96	BRCA2 BRCA1
4	chordate embryonic development	GO:0043009	8.62	BRCA2 BRCA1

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Sources for Nosophobia

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NIH Rare Diseases

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia