MCID: NTL003
MIFTS: 19

Notalgia Paresthetica

Categories: Neuronal diseases, Rare diseases, Skin diseases

Aliases & Classifications for Notalgia Paresthetica

MalaCards integrated aliases for Notalgia Paresthetica:

Name: Notalgia Paresthetica 20 70

Classifications:



External Ids:

UMLS 70 C0457010

Summaries for Notalgia Paresthetica

GARD : 20 Notalgia paresthetica is a common chronic, localized itch, that usually affects patches of skin on the upper back. Occasionally it can be more widespread and involve other parts of the back, the shoulders and upper chest. People feel both the sensation of an itch and paresthesia (a sensation of tingling, pricking, or numbness of the skin). There are no signs on the skin except for signs of chronic scratching and rubbing. Amyloid deposits (a collection of a specific type of protein ) may be found in skin biopsies, but this is thought to be a secondary event. The cause of the itch in notalgia paresthetica may be due to the compression of spinal nerves by bones or muscles as the nerves emerge through the vertebrae to the back muscles. Sometimes degenerative changes in the area of the vertebrae that innervate the affected back muscles can be seen, but not always. Symptoms of notalgia paresthetica may respond to topical capsaicin treatment.

MalaCards based summary : Notalgia Paresthetica is related to pruritus, hereditary localized and sensory peripheral neuropathy. The drugs Acetylcholine and Neurotransmitter Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, thyroid and spinal cord.

Wikipedia : 73 Notalgia paraesthetica (NP) or notalgia paresthetica (also known as "Hereditary localized pruritus",... more...

Related Diseases for Notalgia Paresthetica

Diseases related to Notalgia Paresthetica via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 24)
# Related Disease Score Top Affiliating Genes
1 pruritus, hereditary localized 11.2
2 sensory peripheral neuropathy 10.7
3 paresthesia 10.6
4 dowling-degos disease 1 10.5
5 amyloidosis 10.5
6 mononeuropathy 10.4
7 macular amyloidosis 10.4
8 multiple endocrine neoplasia 10.4
9 multiple endocrine neoplasia, type iia 10.3
10 thyroid carcinoma, familial medullary 10.1
11 body mass index quantitative trait locus 1 10.1
12 exanthem 10.1
13 amyotrophic neuralgia 10.1
14 epidural abscess 10.1
15 neuritis 10.1
16 dermatitis 10.1
17 thyroid gland medullary carcinoma 10.1
18 nerve compression syndrome 10.1
19 spinal stenosis 10.1
20 neuropathy 10.1
21 degenerative disc disease 10.1
22 spinal cord injury 10.1
23 lichen amyloidosis 10.1
24 thyroid carcinoma 10.1

Graphical network of the top 20 diseases related to Notalgia Paresthetica:



Diseases related to Notalgia Paresthetica

Symptoms & Phenotypes for Notalgia Paresthetica

Drugs & Therapeutics for Notalgia Paresthetica

Drugs for Notalgia Paresthetica (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved, Investigational Phase 3 51-84-3 187
2 Neurotransmitter Agents Phase 3
3 abobotulinumtoxinA Phase 3
4 Cholinergic Agents Phase 3
5 Botulinum Toxins, Type A Phase 3
6 Botulinum Toxins Phase 3
7 incobotulinumtoxinA Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficacy and Safety of Xeomin for the Treatment of Notalgia Paresthetica Completed NCT01098019 Phase 3 Xeomin;Placebo / Xeomin
2 A Randomized, Double-blind, Placebo-controlled, Proof-of-concept Study to Evaluate the Efficacy and Safety of Oral Difelikefalin (CR845) for Moderate to Severe Pruritus in Adult Subjects With Notalgia Paresthetica Recruiting NCT04706975 Phase 2 difelikefalin 2.0 mg;Placebo

Search NIH Clinical Center for Notalgia Paresthetica

Genetic Tests for Notalgia Paresthetica

Anatomical Context for Notalgia Paresthetica

MalaCards organs/tissues related to Notalgia Paresthetica:

40
Skin, Thyroid, Spinal Cord

Publications for Notalgia Paresthetica

Articles related to Notalgia Paresthetica:

(show top 50) (show all 97)
# Title Authors PMID Year
1
Notalgia paresthetica: a review for dermatologists. 20 61
29243804 2018
2
Therapeutic Use of Botulinum Neurotoxins in Dermatology: Systematic Review. 61
33562846 2021
3
Effectiveness of 308-nm excimer lamp in the treatment of notalgia paresthetica. 61
33043494 2021
4
Notalgia Paresthetica: Cervical Spine Disease and Neuropathic Pruritus. 61
33654636 2021
5
A minimal invasive treatment option in notalgia paresthetica: Dry needling. 61
32542876 2020
6
The etiology of notalgia paresthetica: a descriptive study of 117 patients. 61
32086681 2020
7
Intralesional triamcinolone acetonide in notalgia paresthetica: Treatment outcomes in five patients. 61
32338414 2020
8
Use of Botulinum Toxin Type A in a Patient With Refractory Itch From Notalgia Paresthetica. 61
32453101 2020
9
Notalgia paresthetica: treatment review and algorithmic approach. 61
30942103 2020
10
Notalgia paresthetica: clinical features, radiological evaluation, and a novel therapeutic option. 61
32416719 2020
11
[Notalgia paresthetica: Treatment with botulinum toxin type A]. 61
32370829 2020
12
Alleviation of notalgia paresthetica with duloxetine after several lines offailed treatment: A case report. 61
32274333 2020
13
Gabapentin treatment in notalgia paresthetica: a preliminary report. 61
31646616 2020
14
Notalgia paresthetica treated with low dose of gabapentin: Case report and literature review. 61
32017311 2020
15
Treatment of Notalgia Paresthetica with Bee Venom and Capsaicin: A Pilot Study with 20 Patients. 61
31904325 2019
16
Physical Medicine and Rehabilitation Role on Notalgia Paresthetica: Case Report and Treatment Review. 61
30439740 2018
17
NOTALGIA PARESTHETICA. 61
31168209 2018
18
Concurrent notalgia paresthetica and brachioradial pruritus associated with cervical degenerative disc disease. 61
30372709 2018
19
An alternative in the treatment of notalgia paresthetica: neural therapy. 61
29911324 2018
20
Notalgia paresthetica: cryolipolysis as a novel potential treatment. 61
29732538 2018
21
Notalgia Paresthetica Relieved by Cervical Traction. 61
29180561 2017
22
A Case Report of Refractory Notalgia Paresthetica Treated with Lidocaine Infusions. 61
29151570 2017
23
Notalgia paresthetica: factors associated with its perceived severity, duration, side, and localization. 61
28646529 2017
24
Laser treatment of medical skin disease in women. 61
28831422 2017
25
Notalgia Paresthetica: A Novel Approach to Treatment with Cryolipolysis. 61
29188163 2017
26
Dorsal scapular nerve neuropathy: a narrative review of the literature. 61
28928496 2017
27
Fluoroscopy induced chronic radiation dermatitis should be included in the differential diagnosis of notalgia paresthetica. 61
28329575 2016
28
Notalgia Paresthetica and Multiple Endocrine Neoplasia Syndrome 2A: A Case Report. 61
27396529 2016
29
Notalgia Paresthetica, A Clinical Series and Review. 61
27260118 2016
30
Notalgia paresthetica: treatment with topical tacrolimus. 61
25388817 2016
31
A Rare Cause of Neuropathic Pain in the Back: Notalgia Paresthetica. 61
28360775 2016
32
Considerable Variability in the Efficacy of 8% Capsaicin Topical Patches in the Treatment of Chronic Pruritus in 3 Patients with Notalgia Paresthetica. 61
26848223 2016
33
Neurocutaneous disease: Neurocutaneous dysesthesias. 61
26775772 2016
34
[An overlooked clinical entity: notalgia paresthetica]. 61
26860498 2015
35
Inverse notalgia paresthetica: a strange case of professional disease. 61
25311242 2015
36
Efficacy of gabapentin in the improvement of pruritus and quality of life of patients with notalgia paresthetica. 61
25054742 2014
37
Neuropathic itch of the back: a case of notalgia paresthetica. 61
24966642 2014
38
Treatment of notalgia paresthetica with botulinum toxin A: a double-blind randomized controlled trial. 61
24831319 2014
39
Notalgia paresthetica: treatment using intradermal botulinum toxin A. 61
24378421 2014
40
The role of capsaicin in dermatology. 61
24941674 2014
41
Effective treatment of notalgia paresthetica with amitriptyline. 61
23621865 2013
42
Neuropathic itch: diagnosis and management. 61
23551367 2013
43
Scalp dysesthesia related to cervical spine disease. 61
23565509 2013
44
Notalgia paresthetica: the unreachable itch. 61
23785628 2013
45
General features and treatment of notalgia paresthetica. 61
22256623 2011
46
Neuropathic itch. 61
21767768 2011
47
Notalgia paresthetica: successful treatment with exercises. 61
21279307 2011
48
Systematic review of topical capsaicin in the treatment of pruritus. 61
21128913 2010
49
Notalgia paresthesica successfully treated with narrow-band UVB: report of five cases. 61
19925596 2010
50
Notalgia paresthetica associated with cervical spinal stenosis and cervicothoracic disk disease at C4 through C7. 61
20349681 2010

Variations for Notalgia Paresthetica

Expression for Notalgia Paresthetica

Search GEO for disease gene expression data for Notalgia Paresthetica.

Pathways for Notalgia Paresthetica

GO Terms for Notalgia Paresthetica

Sources for Notalgia Paresthetica

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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