MCID: NVL002
MIFTS: 17

Novelty Seeking Personality Trait

Aliases & Classifications for Novelty Seeking Personality Trait

MalaCards integrated aliases for Novelty Seeking Personality Trait:

Name: Novelty Seeking Personality Trait 57 29 55
Novelty Seeking, Personality Trait 40
Novelty Seeking Personality 57

Characteristics:

OMIM:

57
Inheritance:
? autosomal dominant.


External Ids:

OMIM 57 601696
MedGen 42 C1866430
SNOMED-CT via HPO 69 88425004

Summaries for Novelty Seeking Personality Trait

OMIM : 57 Human personality traits that can be reliably measured by rating scales show a considerable heritable component. One such instrument is the tridimensional personality questionnaire (TPQ), which was designed by Cloninger et al. (1993) to measure 4 distinct domains of temperament--novelty seeking, harm avoidance, reward dependence, and persistence--that are hypothesized to be based on distinct neurochemical and genetic substrates. Risk-taking is a characteristic of behaviors that occur under conditions of uncertainty and involves a tradeoff between beneficial versus detrimental outcomes, perceived or real. Risk-taking may or may not involve conscious evaluation of the probability and magnitude of possible outcomes (Anokhin et al., 2009). See also harm avoidance (607834) and pathologic gambling (606349), which may be related. (601696)

MalaCards based summary : Novelty Seeking Personality Trait, also known as novelty seeking, personality trait, is related to alcohol dependence and aging. An important gene associated with Novelty Seeking Personality Trait is DRD4 (Dopamine Receptor D4). Related phenotypes are abnormality of the nervous system and impulsivity

Related Diseases for Novelty Seeking Personality Trait

Diseases related to Novelty Seeking Personality Trait via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 alcohol dependence 10.1
2 aging 10.1
3 heroin dependence 10.1
4 fibromyalgia 10.1

Symptoms & Phenotypes for Novelty Seeking Personality Trait

Symptoms via clinical synopsis from OMIM:

57
Neuro:
novelty seeking personality trait
impulsive
exploratory
fickle
excitable
more
Misc:
mediated by variability in dopamine transmission


Clinical features from OMIM:

601696

Human phenotypes related to Novelty Seeking Personality Trait:

32
# Description HPO Frequency HPO Source Accession
1 abnormality of the nervous system 32 HP:0000707
2 impulsivity 32 HP:0100710

Drugs & Therapeutics for Novelty Seeking Personality Trait

Search Clinical Trials , NIH Clinical Center for Novelty Seeking Personality Trait

Genetic Tests for Novelty Seeking Personality Trait

Genetic tests related to Novelty Seeking Personality Trait:

# Genetic test Affiliating Genes
1 Novelty Seeking Personality Trait 29 DRD4

Anatomical Context for Novelty Seeking Personality Trait

Publications for Novelty Seeking Personality Trait

Articles related to Novelty Seeking Personality Trait:

# Title Authors Year
1
Role of novelty seeking personality traits as mediator of the association between COMT and onset age of drug use in Chinese heroin dependent patients. ( 21857968 )
2011
2
An interaction between the norepinephrine transporter and monoamine oxidase A polymorphisms, and novelty-seeking personality traits in Korean females. ( 17920180 )
2008
3
An association between fibromyalgia and the dopamine D4 receptor exon III repeat polymorphism and relationship to novelty seeking personality traits. ( 15052273 )
2004
4
Identification of a polymorphism in the promoter region of DRD4 associated with the human novelty seeking personality trait. ( 10673770 )
2000
5
Treatment attrition among alcohol-dependent men: is it related to novelty seeking personality traits? ( 9934943 )
1999
6
Human novelty-seeking personality traits and dopamine D4 receptor polymorphisms: a twin and genetic association study. ( 9514587 )
1998

Variations for Novelty Seeking Personality Trait

Expression for Novelty Seeking Personality Trait

Search GEO for disease gene expression data for Novelty Seeking Personality Trait.

Pathways for Novelty Seeking Personality Trait

GO Terms for Novelty Seeking Personality Trait

Sources for Novelty Seeking Personality Trait

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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