MCID: NVL002
MIFTS: 14

Novelty Seeking Personality Trait

Categories: Mental diseases

Aliases & Classifications for Novelty Seeking Personality Trait

MalaCards integrated aliases for Novelty Seeking Personality Trait:

Name: Novelty Seeking Personality Trait 57 29 54
Novelty Seeking, Personality Trait 39

Characteristics:

OMIM®:

57 (Updated 20-May-2021)
Inheritance:
? autosomal dominant.


HPO:

31
novelty seeking personality trait:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM® 57 601696
SNOMED-CT via HPO 68 263681008 88425004

Summaries for Novelty Seeking Personality Trait

OMIM® : 57 Human personality traits that can be reliably measured by rating scales show a considerable heritable component. One such instrument is the tridimensional personality questionnaire (TPQ), which was designed by Cloninger et al. (1993) to measure 4 distinct domains of temperament--novelty seeking, harm avoidance, reward dependence, and persistence--that are hypothesized to be based on distinct neurochemical and genetic substrates. Risk-taking is a characteristic of behaviors that occur under conditions of uncertainty and involves a tradeoff between beneficial versus detrimental outcomes, perceived or real. Risk-taking may or may not involve conscious evaluation of the probability and magnitude of possible outcomes (Anokhin et al., 2009). See also harm avoidance (607834) and pathologic gambling (606349), which may be related. (601696) (Updated 20-May-2021)

MalaCards based summary : Novelty Seeking Personality Trait, is also known as novelty seeking, personality trait. An important gene associated with Novelty Seeking Personality Trait is DRD4 (Dopamine Receptor D4). Related phenotypes are abnormality of the nervous system and impulsivity

Related Diseases for Novelty Seeking Personality Trait

Symptoms & Phenotypes for Novelty Seeking Personality Trait

Human phenotypes related to Novelty Seeking Personality Trait:

31
# Description HPO Frequency HPO Source Accession
1 abnormality of the nervous system 31 HP:0000707
2 impulsivity 31 HP:0100710

Symptoms via clinical synopsis from OMIM®:

57 (Updated 20-May-2021)
Neuro:
novelty seeking personality trait
impulsive
exploratory
fickle
excitable
more
Misc:
mediated by variability in dopamine transmission

Clinical features from OMIM®:

601696 (Updated 20-May-2021)

Drugs & Therapeutics for Novelty Seeking Personality Trait

Search Clinical Trials , NIH Clinical Center for Novelty Seeking Personality Trait

Genetic Tests for Novelty Seeking Personality Trait

Genetic tests related to Novelty Seeking Personality Trait:

# Genetic test Affiliating Genes
1 Novelty Seeking Personality Trait 29

Anatomical Context for Novelty Seeking Personality Trait

Publications for Novelty Seeking Personality Trait

Articles related to Novelty Seeking Personality Trait:

(show all 25)
# Title Authors PMID Year
1
Heritability of risk-taking in adolescence: a longitudinal twin study. 57
19653837 2009
2
Financial and psychological risk attitudes associated with two single nucleotide polymorphisms in the nicotine receptor (CHRNA4) gene. 57
19693267 2009
3
Genetic determinants of financial risk taking. 57
19209222 2009
4
Genetic variants implicated in personality: a review of the more promising candidates. 57
15389772 2004
5
A meta-analysis of the association between DRD4 polymorphism and novelty seeking. 57
12192615 2002
6
Human novelty-seeking personality traits and dopamine D4 receptor polymorphisms: a twin and genetic association study. 57
9514587 1998
7
Population and familial association between the D4 dopamine receptor gene and measures of Novelty Seeking. 57
8528258 1996
8
Mapping genes for human personality. 57
8528246 1996
9
Dopamine D4 receptor (D4DR) exon III polymorphism associated with the human personality trait of Novelty Seeking. 57
8528256 1996
10
Modulation of intracellular cyclic AMP levels by different human dopamine D4 receptor variants. 57
7643093 1995
11
Neuroendocrine support for a relationship between "novelty seeking" and dopaminergic function in alcohol-dependent men. 57
8848521 1995
12
A psychobiological model of temperament and character. 57
8250684 1993
13
Association study of catechol-O-methyltransferase gene and dopamine D4 receptor gene polymorphisms and personality traits in healthy young chinese females. 54 61
15292670 2004
14
Identification of a polymorphism in the promoter region of DRD4 associated with the human novelty seeking personality trait. 54 61
10673770 2000
15
Effects of active exploration on novelty-related declarative memory enhancement. 61
33592311 2021
16
An analysis of genetic association in opioid dependence susceptibility. 61
28656735 2018
17
Higher sensitivity to the conditioned rewarding effects of cocaine and MDMA in High-Novelty-Seekers mice exposed to a cocaine binge during adolescence. 61
24908272 2015
18
Psychopathological aspects of dopaminergic gene polymorphisms in adolescence and young adulthood. 61
21527290 2011
19
Personality traits are differentially associated with patterns of reward and novelty processing in the human substantia nigra/ventral tegmental area. 61
18835480 2009
20
Modeling sensitization to stimulants in humans: an [11C]raclopride/positron emission tomography study in healthy men. 61
17146013 2006
21
An association between fibromyalgia and the dopamine D4 receptor exon III repeat polymorphism and relationship to novelty seeking personality traits. 54
15052273 2004
22
Failure to replicate an excess of the long dopamine D4 exon III repeat polymorphism in ADHD in a family-based study. 54
10898899 2000
23
Human dopamine D4 receptor allele genotyping by ultrathin agarose gel electrophoresis with To-Pro-3 complexation. 61
10217162 1999
24
Lack of association between dopamine D4 receptor gene and personality traits. 54
9723153 1998
25
Excess dopamine D4 receptor (D4DR) exon III seven repeat allele in opioid-dependent subjects. 54
9152990 1997

Variations for Novelty Seeking Personality Trait

Expression for Novelty Seeking Personality Trait

Search GEO for disease gene expression data for Novelty Seeking Personality Trait.

Pathways for Novelty Seeking Personality Trait

GO Terms for Novelty Seeking Personality Trait

Sources for Novelty Seeking Personality Trait

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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