MCID: NVL002
MIFTS: 13

Novelty Seeking Personality Trait

Aliases & Classifications for Novelty Seeking Personality Trait

MalaCards integrated aliases for Novelty Seeking Personality Trait:

Name: Novelty Seeking Personality Trait 58 30 56
Novelty Seeking, Personality Trait 41
Novelty Seeking Personality 58

Characteristics:

OMIM:

58
Inheritance:
? autosomal dominant.


HPO:

33
novelty seeking personality trait:
Inheritance autosomal dominant inheritance


External Ids:

OMIM 58 601696
MedGen 43 C1866430
SNOMED-CT via HPO 70 263681008 88425004

Summaries for Novelty Seeking Personality Trait

OMIM : 58 Human personality traits that can be reliably measured by rating scales show a considerable heritable component. One such instrument is the tridimensional personality questionnaire (TPQ), which was designed by Cloninger et al. (1993) to measure 4 distinct domains of temperament--novelty seeking, harm avoidance, reward dependence, and persistence--that are hypothesized to be based on distinct neurochemical and genetic substrates. Risk-taking is a characteristic of behaviors that occur under conditions of uncertainty and involves a tradeoff between beneficial versus detrimental outcomes, perceived or real. Risk-taking may or may not involve conscious evaluation of the probability and magnitude of possible outcomes (Anokhin et al., 2009). See also harm avoidance (607834) and pathologic gambling (606349), which may be related. (601696)

MalaCards based summary : Novelty Seeking Personality Trait, also known as novelty seeking, personality trait, is related to fibromyalgia. An important gene associated with Novelty Seeking Personality Trait is DRD4 (Dopamine Receptor D4). Related phenotypes are abnormality of the nervous system and impulsivity

Related Diseases for Novelty Seeking Personality Trait

Diseases related to Novelty Seeking Personality Trait via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 fibromyalgia 10.2

Symptoms & Phenotypes for Novelty Seeking Personality Trait

Human phenotypes related to Novelty Seeking Personality Trait:

33
# Description HPO Frequency HPO Source Accession
1 abnormality of the nervous system 33 HP:0000707
2 impulsivity 33 HP:0100710

Symptoms via clinical synopsis from OMIM:

58
Neuro:
novelty seeking personality trait
impulsive
exploratory
fickle
excitable
more
Misc:
mediated by variability in dopamine transmission

Clinical features from OMIM:

601696

Drugs & Therapeutics for Novelty Seeking Personality Trait

Search Clinical Trials , NIH Clinical Center for Novelty Seeking Personality Trait

Genetic Tests for Novelty Seeking Personality Trait

Genetic tests related to Novelty Seeking Personality Trait:

# Genetic test Affiliating Genes
1 Novelty Seeking Personality Trait 30 DRD4

Anatomical Context for Novelty Seeking Personality Trait

Publications for Novelty Seeking Personality Trait

Articles related to Novelty Seeking Personality Trait:

# Title Authors Year
1
Identification of a polymorphism in the promoter region of DRD4 associated with the human novelty seeking personality trait. ( 10673770 )
2000

Variations for Novelty Seeking Personality Trait

Expression for Novelty Seeking Personality Trait

Search GEO for disease gene expression data for Novelty Seeking Personality Trait.

Pathways for Novelty Seeking Personality Trait

GO Terms for Novelty Seeking Personality Trait

Sources for Novelty Seeking Personality Trait

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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