MCID: NCL001
MIFTS: 19

Nuclear Senile Cataract

Categories: Eye diseases

Aliases & Classifications for Nuclear Senile Cataract

MalaCards integrated aliases for Nuclear Senile Cataract:

Name: Nuclear Senile Cataract 12 15
Senile Nuclear Sclerosis 12
Senile Nuclear Cataract 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13963
ICD9CM 35 366.16
SNOMED-CT 68 193589009 46129005
ICD10 33 H25.1
UMLS 73 C0271166

Summaries for Nuclear Senile Cataract

MalaCards based summary : Nuclear Senile Cataract, also known as senile nuclear sclerosis, is related to cataract and mature cataract. An important gene associated with Nuclear Senile Cataract is CRYAA (Crystallin Alpha A). Affiliated tissues include eye, and related phenotype is vision/eye.

Related Diseases for Nuclear Senile Cataract

Diseases related to Nuclear Senile Cataract via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 cataract 28.5 CRYAA CRYGD CRYGS
2 mature cataract 10.2 CRYAA CRYGS
3 eye accommodation disease 10.2 CRYAA CRYGS
4 presbyopia 10.1 CRYAA CRYGS
5 early-onset nuclear cataract 10.0 CRYAA CRYGD
6 cataract microcornea syndrome 10.0 CRYAA CRYGD
7 blood group, globoside system 9.9 CRYAA CRYGS
8 cataract 16, multiple types 9.7 CRYAA CRYGD CRYGS
9 lens disease 9.6 CRYAA CRYGS LAMA3

Graphical network of the top 20 diseases related to Nuclear Senile Cataract:



Diseases related to Nuclear Senile Cataract

Symptoms & Phenotypes for Nuclear Senile Cataract

MGI Mouse Phenotypes related to Nuclear Senile Cataract:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 vision/eye MP:0005391 8.92 CRYGD CRYGS LGI1 TYR

Drugs & Therapeutics for Nuclear Senile Cataract

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Resident-Performed Laser-Assisted vs Manual Traditional Phacoemulsification Cataract Surgery Recruiting NCT02561104 Not Applicable

Search NIH Clinical Center for Nuclear Senile Cataract

Genetic Tests for Nuclear Senile Cataract

Anatomical Context for Nuclear Senile Cataract

MalaCards organs/tissues related to Nuclear Senile Cataract:

41
Eye

Publications for Nuclear Senile Cataract

Articles related to Nuclear Senile Cataract:

# Title Authors Year
1
Decolouration of the lens pigment in senile nuclear cataract. ( 2128539 )
1990

Variations for Nuclear Senile Cataract

Expression for Nuclear Senile Cataract

Search GEO for disease gene expression data for Nuclear Senile Cataract.

Pathways for Nuclear Senile Cataract

GO Terms for Nuclear Senile Cataract

Biological processes related to Nuclear Senile Cataract according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lens development in camera-type eye GO:0002088 8.96 CRYGD CRYGS
2 visual perception GO:0007601 8.8 CRYAA CRYGD TYR

Molecular functions related to Nuclear Senile Cataract according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of eye lens GO:0005212 8.8 CRYAA CRYGD CRYGS

Sources for Nuclear Senile Cataract

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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