MCID: NCL001
MIFTS: 28

Nuclear Senile Cataract

Categories: Eye diseases, Genetic diseases, Neuronal diseases

Aliases & Classifications for Nuclear Senile Cataract

MalaCards integrated aliases for Nuclear Senile Cataract:

Name: Nuclear Senile Cataract 12 15
Senile Nuclear Cataract 12 32
Senile Nuclear Sclerosis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13963
ICD9CM 34 366.16
SNOMED-CT 67 193589009
ICD10 32 H25.1
UMLS 70 C0271166

Summaries for Nuclear Senile Cataract

Disease Ontology : 12 A senile cataract that is characterized by opacification of the lens nucleus and caused by changes related to aging.

MalaCards based summary : Nuclear Senile Cataract, also known as senile nuclear cataract, is related to senile cataract and cataract. An important gene associated with Nuclear Senile Cataract is CRYGS (Crystallin Gamma S), and among its related pathways/superpathways are Alzheimers Disease and NRF2 pathway. Affiliated tissues include eye, endothelial and breast, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Nuclear Senile Cataract

Graphical network of the top 20 diseases related to Nuclear Senile Cataract:



Diseases related to Nuclear Senile Cataract

Symptoms & Phenotypes for Nuclear Senile Cataract

GenomeRNAi Phenotypes related to Nuclear Senile Cataract according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-1 9.83 CAPN2
2 Decreased viability GR00055-A-2 9.83 CAPN2
3 Decreased viability GR00106-A-0 9.83 CAPN2
4 Decreased viability GR00240-S-1 9.83 MYOM2
5 Decreased viability GR00249-S 9.83 ATP2B1 CAPN2 GSR NQO1
6 Decreased viability GR00381-A-1 9.83 NQO1 P4HB
7 Decreased viability GR00386-A-1 9.83 CAPN2 EGR1 NQO1
8 Decreased viability GR00402-S-2 9.83 CRYGC TP53INP1
9 Increased the percentage of infected cells GR00402-S-1 8.32 CAPN1

MGI Mouse Phenotypes related to Nuclear Senile Cataract:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.65 ATP2A2 ATP2B1 BFSP1 CAPN1 CAPN2 CRYGC
2 growth/size/body region MP:0005378 9.4 ATP2A2 ATP2B1 BFSP1 CRYGC EGR1 GIP

Drugs & Therapeutics for Nuclear Senile Cataract

Search Clinical Trials , NIH Clinical Center for Nuclear Senile Cataract

Genetic Tests for Nuclear Senile Cataract

Anatomical Context for Nuclear Senile Cataract

MalaCards organs/tissues related to Nuclear Senile Cataract:

40
Eye, Endothelial, Breast

Publications for Nuclear Senile Cataract

Articles related to Nuclear Senile Cataract:

(show all 25)
# Title Authors PMID Year
1
Femtosecond Laser-Assisted Cataract Surgery in Soft and Hard Nuclear Cataracts: A Comparison of Effective Phacoemulsification Time. 61
33731984 2021
2
Comparative analysis of human γD-crystallin aggregation under physiological and low pH conditions. 61
25389780 2014
3
Determination of the density of human nuclear cataract lenses. 61
24026512 2013
4
[Comparative prospective study of 14% and 67% duty cycles of the ultrasound power with WhiteStar in the phacoemulsification cataract surgery using the nuclear preslice technique]. 61
19039466 2008
5
Ultrasound energy and endothelial cell loss with stop-and-chop and nuclear preslice phacoemulsification. 61
17010864 2006
6
Glutathione: a vital lens antioxidant. 61
10803423 2000
7
Non-oxidative modification of lens crystallins by kynurenine: a novel post-translational protein modification with possible relevance to ageing and cataract. 61
10669791 2000
8
Age-related changes in the kinetics of water transport in normal human lenses. 61
10620395 1999
9
Regulation of indoleamine 2,3-dioxygenase, the first enzyme in UV filter biosynthesis in the human lens. Relevance for senile nuclear cataract. 61
10721062 1999
10
Oxidation products of 3-hydroxykynurenine bind to lens proteins: relevance for nuclear cataract. 61
9245903 1997
11
An unusual coloured compound in digests of senile nuclear cataract lens proteins. 61
1376144 1992
12
Total lactate dehydrogenase and its isoenzyme pattern in lens, aqueous humour, and serum in cases of senile cataract. 61
2028768 1991
13
Development of fluorescence and cross-links in eye lens crystallin by interaction with lipid peroxy radicals. 61
2001425 1991
14
Decolouration of the lens pigment in senile nuclear cataract. 61
2128539 1990
15
The reaction of proteins with 3-hydroxyanthranilic acid as a possible model for senile nuclear cataract in man. 61
2515071 1989
16
[Trace element contents in the transparent lens and the senile cataract lens]. 61
2620619 1989
17
The state of sulphydryl groups in proteins isolated from normal and cataractous human lenses. 61
3665565 1987
18
Selenium-induced cataract--a correlation of dry mass content and light scattering. 61
3956603 1986
19
Conformational changes in soluble lens proteins during the development of senile nuclear cataract. 61
6713956 1984
20
Singlet oxygen as a possible factor in human senile nuclear cataract development. 61
6690229 1984
21
Availability of protein amino groups in senile nuclear cataract. 61
6406954 1983
22
Protein and electrolyte alterations in human senile cataract. 61
7151882 1982
23
A note on a possible relation between refraction and a disposition for senile nuclear cataract. 61
7437390 1980
24
Oxidative changes in human lens proteins during senile nuclear cataract formation. 61
861252 1977
25
Protein changes in the human lens during development of senile nuclear cataract. 61
938670 1976

Variations for Nuclear Senile Cataract

Expression for Nuclear Senile Cataract

Search GEO for disease gene expression data for Nuclear Senile Cataract.

Pathways for Nuclear Senile Cataract

Pathways related to Nuclear Senile Cataract according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.51 CAPN2 CAPN1 ATP2A2
2 11.29 NQO1 GSR EGR1
3 10.74 SLC8A1 MT-CO1 ATP2A2

GO Terms for Nuclear Senile Cataract

Biological processes related to Nuclear Senile Cataract according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.97 P4HB NQO1 MT-CO1 LDHC GSR
2 calcium ion transport GO:0006816 9.73 SLC8A1 ATP2B1 ATP2A2
3 calcium ion transmembrane transport GO:0070588 9.72 SLC8A1 ATP2B1 ATP2A2
4 response to oxidative stress GO:0006979 9.71 SELENOP NQO1 MT-CO1
5 cellular calcium ion homeostasis GO:0006874 9.69 SLC8A1 ATP2B1 ATP2A2
6 visual perception GO:0007601 9.62 CRYGS CRYGD CRYGC CRYGB
7 response to glucose GO:0009749 9.61 SLC8A1 GIP EGR1
8 regulation of the force of heart contraction GO:0002026 9.52 SLC8A1 ATP2A2
9 negative regulation of cytosolic calcium ion concentration GO:0051481 9.49 SLC8A1 ATP2B1
10 response to carbohydrate GO:0009743 9.48 NQO1 GIP
11 relaxation of cardiac muscle GO:0055119 9.46 SLC8A1 ATP2A2
12 cell redox homeostasis GO:0045454 9.43 P4HB NQO1 GSR
13 lens fiber cell development GO:0070307 9.4 CRYGB BFSP1
14 regulation of cardiac muscle contraction by calcium ion signaling GO:0010882 9.37 SLC8A1 ATP2A2
15 regulation of cardiac conduction GO:1903779 9.33 SLC8A1 ATP2B1 ATP2A2
16 calcium ion export GO:1901660 8.96 SLC8A1 ATP2B1
17 lens development in camera-type eye GO:0002088 8.92 CRYGS CRYGD CRYGC CRYGB

Molecular functions related to Nuclear Senile Cataract according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 calcium-dependent cysteine-type endopeptidase activity GO:0004198 9.16 CAPN2 CAPN1
2 structural constituent of eye lens GO:0005212 9.02 CRYGS CRYGD CRYGC CRYGB BFSP1
3 calcium-transporting ATPase activity GO:0005388 8.96 ATP2B1 ATP2A2

Sources for Nuclear Senile Cataract

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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