MCID: NLL001
MIFTS: 30

Null-Cell Leukemia

Categories: Blood diseases, Cancer diseases, Immune diseases

Aliases & Classifications for Null-Cell Leukemia

MalaCards integrated aliases for Null-Cell Leukemia:

Name: Null-Cell Leukemia 12 15
Null Cell Acute Lymphoblastic Leukemia 12 70
Null Cell Acute Lymphoblastic Leukaemia 12
Null-Cell Leukaemia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9954
SNOMED-CT 67 277574007
UMLS 70 C0023483

Summaries for Null-Cell Leukemia

MalaCards based summary : Null-Cell Leukemia, also known as null cell acute lymphoblastic leukemia, is related to leukemia, acute lymphoblastic and cerebral meningioma. An important gene associated with Null-Cell Leukemia is PHYH (Phytanoyl-CoA 2-Hydroxylase), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Allograft rejection. Affiliated tissues include bone marrow, monocytes and t cells, and related phenotype is liver/biliary system.

Related Diseases for Null-Cell Leukemia

Diseases related to Null-Cell Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 204)
# Related Disease Score Top Affiliating Genes
1 leukemia, acute lymphoblastic 10.4
2 cerebral meningioma 10.1 LIF IL6
3 leukemia 10.1
4 thyrotoxic exophthalmos 10.1 MME IL6
5 endocrine exophthalmos 10.1 MME IL6
6 necrotizing fasciitis 10.1 LTA IL6
7 polyclonal hypergammaglobulinemia 10.1 MME IL6
8 micronodular basal cell carcinoma 10.0 MME IFNA1
9 squamous papillomatosis 10.0 MME IFNA1
10 transient hypogammaglobulinemia 10.0 TNF LTA
11 external pathological resorption 9.9 TNF IL6
12 scorpion envenomation 9.9 TNF IL6
13 physiological polycythemia 9.9 TNF IL6
14 idiopathic anterior uveitis 9.9 TNF IL6
15 angioimmunoblastic lymphadenopathy with dysproteinemia 9.9 TNF IL6
16 cardiogenic shock 9.9 TNF IL6
17 chromophil adenoma of the kidney 9.9 TNF MME
18 ulcer of lower limbs 9.9 TNF IL6
19 systemic onset juvenile idiopathic arthritis 9.9 TNF IL6
20 posterior urethral valves 9.9 TNF IL6
21 bacterial conjunctivitis 9.9 TNF IL6
22 tracheitis 9.9 TNF IL6
23 carbuncle 9.9 TNF IL6
24 hypopyon 9.9 TNF IL6
25 enterocolitis 9.9 TNF IL6
26 eales disease 9.9 TNF IL6
27 tenosynovitis 9.9 TNF IL6
28 aortitis 9.9 TNF IL6
29 coronary aneurysm 9.9 TNF IL6
30 chondromalacia 9.9 TNF IL6
31 anthracosis 9.9 TNF IL6
32 progressive myoclonus epilepsy 8 9.9 TNF IL6
33 lung abscess 9.9 TNF IL6
34 heart aneurysm 9.9 TNF IL6
35 neurotic disorder 9.9 TNF IL6
36 peptic esophagitis 9.9 TNF IL6
37 bursitis 9.9 TNF IL6
38 scleral disease 9.9 TNF IL6
39 gingival recession 9.9 TNF IL6
40 retinitis pigmentosa 55 9.9 TNF IL6
41 combat disorder 9.9 TNF IL6
42 laryngitis 9.9 TNF IL6
43 salpingitis 9.9 TNF IL6
44 vaginal discharge 9.9 TNF IL6
45 irritant dermatitis 9.9 TNF IL6
46 iritis 9.9 TNF IL6
47 background diabetic retinopathy 9.9 TNF IL6
48 chorioretinitis 9.9 TNF IL6
49 periapical periodontitis 9.9 TNF IL6
50 trichomoniasis 9.9 TNF IL6

Graphical network of the top 20 diseases related to Null-Cell Leukemia:



Diseases related to Null-Cell Leukemia

Symptoms & Phenotypes for Null-Cell Leukemia

MGI Mouse Phenotypes related to Null-Cell Leukemia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 liver/biliary system MP:0005370 9.17 EMB IL6 LIF LTA MME PHYH

Drugs & Therapeutics for Null-Cell Leukemia

Search Clinical Trials , NIH Clinical Center for Null-Cell Leukemia

Genetic Tests for Null-Cell Leukemia

Anatomical Context for Null-Cell Leukemia

MalaCards organs/tissues related to Null-Cell Leukemia:

40
Bone Marrow, Monocytes, T Cells, B Cells

Publications for Null-Cell Leukemia

Articles related to Null-Cell Leukemia:

(show all 29)
# Title Authors PMID Year
1
Molecular analysis of a t(11;14)(q23;q11) from a patient with null-cell acute lymphoblastic leukemia. 61
7688554 1993
2
Initial characterization of a cytokine which induces differentiation and cytolytic activity in HL-60 promyelocytic leukemia cells: evidence that the cytokine is distinct from other known differentiation-active cytokines. 61
2152942 1990
3
P48 induces tumor necrosis factor and IL-1 secretion by human monocytes. 61
2809197 1989
4
Gene expression of terminal deoxynucleotidyl transferase in neoplastic cells of leukemia and lymphoma. 61
2501250 1989
5
Mesangiolytic glomerulopathy in a bone marrow allograft recipient. 61
2656494 1989
6
Synovial fluid involvement in null cell acute lymphoblastic leukemia diagnosed with monoclonal antibodies. 61
3164075 1988
7
The French-American-British (FAB) classification of leukemia. The Pediatric Oncology Group experience with lymphocytic leukemia. 61
3484662 1986
8
An analysis of the presence of Fc receptors on bone marrow lymphoblasts in acute lymphoblastic leukemia. A Pediatric Oncology Group study. 61
3875396 1985
9
[Leukemias]. 61
2937023 1985
10
Long-term relapse-free survival in adult acute lymphoblastic leukemia. 61
3855697 1985
11
Two new monoclonal antibodies (LN-1, LN-2) reactive in B5 formalin-fixed, paraffin-embedded tissues with follicular center and mantle zone human B lymphocytes and derived tumors. 61
6376628 1984
12
An Ia-like antigen positive null cell leukemia cell line (THP-5) lacking in the stimulating capacity in autologous and allogeneic mixed lymphocyte reaction. 61
6232734 1984
13
Heterogeneity of acute lymphocytic leukemia cell surface markers as detected by monoclonal antibodies. 61
6602900 1983
14
Clinical implications of glucocorticoid receptors in human leukemia. 61
6956240 1982
15
Immunoregulation by blasts from null cell and T-cell leukemias: help and suppression of T-cell proliferative responses to mitogens. 61
6459155 1982
16
Ataxia telangiectasia and acute lymphoblastic leukemia: report of a case. 61
6950588 1981
17
Adenosine deaminase activity in lymphoid subpopulations and leukemias. 61
6972803 1981
18
Humoral helper activity for B-cell differentiation released from non-Hodgkin's lymphoma cells having both SRBC and complement receptors in the pokeweed mitogen system. 61
6971666 1981
19
Cytogenetic abnormalities in a human null cell leukemia line (REH). 61
6942909 1981
20
Acute myeloblastic leukemia masquerading as null-cell acute lymphoblastic leukemia. 61
6938777 1981
21
Null-cell leukemia in course of T-cell lymphoma. 61
6970352 1981
22
Cell surface markers in acute lymphoblastic leukemia. 61
6967278 1980
23
Null cell (non-T, non-B) acute lymphoblastic leukemia terminating as malignant histiocytosis. 61
6929651 1980
24
A study of surface markers in acute lymphocytic leukemia by using anti-T and anti-B lymphocyte sera. 61
310335 1978
25
Helix pomatia A hemagglutinin: selectivity of binding to lymphocyte surface glycoproteins on T cells and certain B cells. 61
309819 1978
26
Correlation of adenosine deaminase activity with cell surface markers in acute lymphoblastic leukemia. 61
308513 1978
27
Characterization of a unique cell line (LAZ 221) from human acute lymphocytic ("null" cell) leukemia. 61
205365 1978
28
T and B lymphocyte antigen-positive null cell leukemias. 61
65190 1977
29
Establishment and characterization of leukemic T-cell lines, B-cell lines, and null-cell line: a progress report on surface antigen study of fresh lymphatic leukemias in man. 61
305398 1977

Variations for Null-Cell Leukemia

Expression for Null-Cell Leukemia

Search GEO for disease gene expression data for Null-Cell Leukemia.

Pathways for Null-Cell Leukemia

Pathways related to Null-Cell Leukemia according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.09 TNF LTA LIF IL6 IFNA1
2
Show member pathways
12.57 TNF LTA IL6 IFNA1
3 12.51 TNF LTA IL6 IFNA1
4 11.99 TNF IL6 IFNA1
5 11.98 TNF IL6 IFNA1
6
Show member pathways
11.88 TNF LTA IL6 IFNA1
7 11.77 TNF LIF IL6
8 11.7 TNF MME IL6
9 11.67 TNF LIF IL6
10 11.58 TNF MME IL6
11
Show member pathways
11.38 TNF LTA IL6
12 11.3 TNF MME IL6
13 11.15 TNF LTA IL6
14 11.04 TNF IL6
15 10.97 TNF LTA LIF IL6
16 10.88 TNF IL6
17 10.82 TNF LIF IL6
18 10.77 TNF LTA LIF IL6
19 10.77 TNF IL6

GO Terms for Null-Cell Leukemia

Biological processes related to Null-Cell Leukemia according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.83 TNF LTA LIF IL6
2 cytokine-mediated signaling pathway GO:0019221 9.71 TNF LIF IL6 IFNA1
3 defense response to Gram-positive bacterium GO:0050830 9.65 TNF LTA IL6
4 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.61 TNF LIF IL6
5 negative regulation of neurogenesis GO:0050768 9.56 TNF IL6
6 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.55 TNF IL6
7 positive regulation of peptidyl-serine phosphorylation of STAT protein GO:0033141 9.54 LIF IFNA1
8 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.51 TNF IL6
9 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.5 TNF LIF IL6
10 positive regulation of neuroinflammatory response GO:0150078 9.49 TNF IL6
11 negative regulation of lipid storage GO:0010888 9.46 TNF IL6
12 vascular endothelial growth factor production GO:0010573 9.37 TNF IL6
13 positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0002925 9.26 TNF LTA
14 positive regulation of chronic inflammatory response to antigenic stimulus GO:0002876 9.16 TNF LTA
15 positive regulation of glial cell proliferation GO:0060252 9.13 TNF LTA IL6
16 humoral immune response GO:0006959 8.92 TNF LTA IL6 IFNA1

Molecular functions related to Null-Cell Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 TNF LTA LIF IL6 IFNA1

Sources for Null-Cell Leukemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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