MCID: NLL001
MIFTS: 32

Null-Cell Leukemia

Categories: Blood diseases, Cancer diseases, Immune diseases

Aliases & Classifications for Null-Cell Leukemia

MalaCards integrated aliases for Null-Cell Leukemia:

Name: Null-Cell Leukemia 12 15
Null Cell Acute Lymphoblastic Leukemia 12 74

Classifications:



External Ids:

Disease Ontology 12 DOID:9954
UMLS 74 C0023483

Summaries for Null-Cell Leukemia

MalaCards based summary : Null-Cell Leukemia, also known as null cell acute lymphoblastic leukemia, is related to leukemia, acute lymphoblastic and lymphocytic leukemia. An important gene associated with Null-Cell Leukemia is LTA (Lymphotoxin Alpha), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Allograft rejection. Affiliated tissues include t cells, lymph node and eye, and related phenotypes are liver/biliary system and respiratory system

Related Diseases for Null-Cell Leukemia

Diseases related to Null-Cell Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 106)
# Related Disease Score Top Affiliating Genes
1 leukemia, acute lymphoblastic 10.3
2 lymphocytic leukemia 10.3
3 necrotizing fasciitis 10.3 IL6 LTA
4 transient hypogammaglobulinemia 10.3 LTA TNF
5 idiopathic achalasia 10.3 LTA TNF
6 encephalitozoonosis 10.3 PHYH TNF
7 listeria meningitis 10.3 LTA TNF
8 sympathetic ophthalmia 10.3 LTA TNF
9 spondylarthropathy 10.2 LTA TNF
10 leukemia 10.2
11 jejunoileitis 10.2 ALDH7A1 TNF
12 scorpion envenomation 10.2 IL6 TNF
13 leukomalacia 10.2 IL6 TNF
14 angioimmunoblastic lymphadenopathy with dysproteinemia 10.2 IL6 TNF
15 autoimmune myocarditis 10.2 IL6 TNF
16 critical limb ischemia 10.2 IL6 TNF
17 juvenile ankylosing spondylitis 10.2 IL6 TNF
18 cardiogenic shock 10.2 IL6 TNF
19 retinitis pigmentosa 55 10.2 IL6 TNF
20 glossitis 10.2 IL6 TNF
21 laryngitis 10.2 IL6 TNF
22 acute vascular insufficiency of intestine 10.2 IL6 TNF
23 posterior urethral valves 10.2 IL6 TNF
24 osteosclerotic myeloma 10.2 IL6 TNF
25 poems syndrome 10.2 IL6 TNF
26 periapical periodontitis 10.2 IL6 TNF
27 autoimmune gastritis 10.2 IL6 TNF
28 meconium aspiration syndrome 10.2 IL6 TNF
29 burning mouth syndrome 10.2 IL6 TNF
30 central nervous system vasculitis 10.2 IL6 TNF
31 ileitis 10.2 IL6 TNF
32 louse-borne relapsing fever 10.2 IL6 TNF
33 endometrial disease 10.1 IL6 TNF
34 listeriosis 10.1 IL6 TNF
35 fasciitis 10.1 IL6 TNF
36 ischemic heart disease 10.1 IL6 TNF
37 autoimmune disease of eyes, ear, nose and throat 10.1 IL6 TNF
38 intermediate uveitis 10.1 IL6 TNF
39 transverse myelitis 10.1 IL6 TNF
40 myelitis 10.1 IL6 TNF
41 crimean-congo hemorrhagic fever 10.1 IL6 TNF
42 posterior uveitis 10.1 IL6 TNF
43 mycoplasma pneumoniae pneumonia 10.1 IL6 TNF
44 hypersensitivity reaction type iii disease 10.1 IL6 TNF
45 eales disease 10.1 IL6 TNF
46 stromal keratitis 10.1 IL6 TNF
47 hematopoietic stem cell transplantation 10.1 IL6 TNF
48 endometritis 10.1 IL6 TNF
49 pulpitis 10.1 IL6 TNF
50 joint disorders 10.1 IL6 TNF

Graphical network of the top 20 diseases related to Null-Cell Leukemia:



Diseases related to Null-Cell Leukemia

Symptoms & Phenotypes for Null-Cell Leukemia

MGI Mouse Phenotypes related to Null-Cell Leukemia:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 liver/biliary system MP:0005370 9.35 IL6 LIF LTA PHYH TNF
2 respiratory system MP:0005388 9.02 CHL1 IL6 LIF LTA TNF

Drugs & Therapeutics for Null-Cell Leukemia

Search Clinical Trials , NIH Clinical Center for Null-Cell Leukemia

Genetic Tests for Null-Cell Leukemia

Anatomical Context for Null-Cell Leukemia

MalaCards organs/tissues related to Null-Cell Leukemia:

42
T Cells, Lymph Node, Eye, Spinal Cord, Prostate, Tonsil

Publications for Null-Cell Leukemia

Articles related to Null-Cell Leukemia:

# Title Authors Year
1
Molecular analysis of a t(11;14)(q23;q11) from a patient with null-cell acute lymphoblastic leukemia. ( 7688554 )
1993
2
Synovial fluid involvement in null cell acute lymphoblastic leukemia diagnosed with monoclonal antibodies. ( 3164075 )
1988
3
An Ia-like antigen positive null cell leukemia cell line (THP-5) lacking in the stimulating capacity in autologous and allogeneic mixed lymphocyte reaction. ( 6232734 )
1984
4
Cytogenetic abnormalities in a human null cell leukemia line (REH). ( 6942909 )
1981
5
Null-cell leukemia in course of T-cell lymphoma. ( 6970352 )
1981
6
Acute myeloblastic leukemia masquerading as null-cell acute lymphoblastic leukemia. ( 6938777 )
1981
7
Characterization of a unique cell line (LAZ 221) from human acute lymphocytic ("null" cell) leukemia. ( 205365 )
1978

Variations for Null-Cell Leukemia

Expression for Null-Cell Leukemia

Search GEO for disease gene expression data for Null-Cell Leukemia.

Pathways for Null-Cell Leukemia

Pathways related to Null-Cell Leukemia according to GeneCards Suite gene sharing:

(show all 20)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.03 IFNA1 IL6 LIF LTA TNF
2
Show member pathways
12.58 IFNA1 IL6 LTA TNF
3 12.11 IL6 LTA TNF
4 11.91 IFNA1 IL6 TNF
5
Show member pathways
11.77 IFNA1 IL6 LTA TNF
6 11.7 IL6 LIF TNF
7
Show member pathways
11.66 IL6 LTA TNF
8 11.55 IL6 LIF TNF
9 11.15 IL6 TNF
10 11.12 IL6 TNF
11 11.1 IL6 LIF
12 11.06 IL6 TNF
13 11.04 IL6 TNF
14 11.02 IL6 LIF TNF
15 10.97 IL6 TNF
16 10.97 IL6 LIF LTA TNF
17 10.8 IL6 TNF
18 10.71 IL6 TNF
19 10.7 IL6 LIF LTA TNF
20 10.49 IL6 LIF LTA TNF

GO Terms for Null-Cell Leukemia

Cellular components related to Null-Cell Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.1 CHL1 IFNA1 IL6 LIF LTA TNF

Biological processes related to Null-Cell Leukemia according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.84 IL6 LIF LTA TNF
2 cytokine-mediated signaling pathway GO:0019221 9.71 IFNA1 IL6 LIF TNF
3 defense response to Gram-positive bacterium GO:0050830 9.65 IL6 LTA TNF
4 regulation of signaling receptor activity GO:0010469 9.65 IFNA1 IL6 LIF LTA TNF
5 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.61 IL6 LIF TNF
6 response to exogenous dsRNA GO:0043330 9.56 IFNA1 SLC3A2
7 negative regulation of neurogenesis GO:0050768 9.55 IL6 TNF
8 positive regulation of chemokine production GO:0032722 9.52 IL6 TNF
9 positive regulation of peptidyl-serine phosphorylation of STAT protein GO:0033141 9.51 IFNA1 LIF
10 negative regulation of growth of symbiont in host GO:0044130 9.49 LTA TNF
11 negative regulation of lipid storage GO:0010888 9.46 IL6 TNF
12 positive regulation of neuroinflammatory response GO:0150078 9.37 IL6 TNF
13 positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0002925 9.32 LTA TNF
14 positive regulation of chronic inflammatory response to antigenic stimulus GO:0002876 9.16 LTA TNF
15 positive regulation of glial cell proliferation GO:0060252 9.13 IL6 LTA TNF
16 humoral immune response GO:0006959 8.92 IFNA1 IL6 LTA TNF

Molecular functions related to Null-Cell Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 IFNA1 IL6 LIF LTA TNF
2 tumor necrosis factor receptor binding GO:0005164 8.96 LTA TNF

Sources for Null-Cell Leukemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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