MCID: NLL001
MIFTS: 30

Null-Cell Leukemia

Categories: Blood diseases, Cancer diseases, Immune diseases

Aliases & Classifications for Null-Cell Leukemia

MalaCards integrated aliases for Null-Cell Leukemia:

Name: Null-Cell Leukemia 12 15
Null Cell Acute Lymphoblastic Leukemia 12 71
Null Cell Acute Lymphoblastic Leukaemia 12
Null-Cell Leukaemia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9954
SNOMED-CT 67 277574007
UMLS 71 C0023483

Summaries for Null-Cell Leukemia

MalaCards based summary : Null-Cell Leukemia, also known as null cell acute lymphoblastic leukemia, is related to thymoma and liver lymphoma. An important gene associated with Null-Cell Leukemia is AKAP17A (A-Kinase Anchoring Protein 17A), and among its related pathways/superpathways are Herpes simplex virus 1 infection and Immune response IFN alpha/beta signaling pathway. Affiliated tissues include t cells, b cells and bone marrow, and related phenotype is liver/biliary system.

Related Diseases for Null-Cell Leukemia

Diseases related to Null-Cell Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 167)
# Related Disease Score Top Affiliating Genes
1 thymoma 28.8 TNF IL6 IFNA1
2 liver lymphoma 10.3 MME AKAP17A
3 leukemia 10.3
4 spondylarthropathy 10.2 TNF LTA
5 transient hypogammaglobulinemia 10.2 TNF LTA
6 chromophil adenoma of the kidney 10.1 TNF MME
7 lymphoma 10.1
8 micronodular basal cell carcinoma 10.0 MME IFNA1
9 skin sarcoidosis 10.0 TNF IFNA1
10 superficial basal cell carcinoma 10.0 TNF IFNA1
11 adult dermatomyositis 10.0 TNF IFNA1
12 squamous papillomatosis 9.9 MME IFNA1
13 thymoma, familial 9.9
14 leukemia, acute lymphoblastic 9.9
15 splenic manifestation of leukemia 9.9
16 t-cell lymphoblastic leukemia/lymphoma 9.9
17 leukemia, t-cell, chronic 9.9
18 lymphosarcoma 9.9
19 external pathological resorption 9.9 TNF IL6
20 scorpion envenomation 9.9 TNF IL6
21 idiopathic anterior uveitis 9.9 TNF IL6
22 angioimmunoblastic lymphadenopathy with dysproteinemia 9.9 TNF IL6
23 thyrotoxic exophthalmos 9.9 MME IL6
24 endocrine exophthalmos 9.9 MME IL6
25 anaerobic pneumonia 9.8 TNF IL6
26 macs syndrome 9.8 TNF IFNA1
27 posterior urethral valves 9.8 TNF IL6
28 post-cardiac arrest syndrome 9.8 TNF IL6
29 transverse myelitis 9.8 TNF IL6
30 eales disease 9.8 TNF IL6
31 tracheitis 9.8 TNF IL6
32 carbuncle 9.8 TNF IL6
33 chemical colitis 9.8 TNF IL6
34 heart aneurysm 9.8 TNF IL6
35 aortitis 9.8 TNF IL6
36 coronary aneurysm 9.8 TNF IL6
37 hypopyon 9.8 TNF IL6
38 tenosynovitis 9.8 TNF IL6
39 chondromalacia 9.8 TNF IL6
40 pneumonic tularemia 9.8 TNF IL6
41 blastomycosis 9.8 TNF IL6
42 retinitis pigmentosa 55 9.8 TNF IL6
43 scleral disease 9.8 TNF IL6
44 progressive myoclonus epilepsy 8 9.8 TNF IL6
45 lung abscess 9.8 TNF IL6
46 chlamydia pneumonia 9.8 TNF IL6
47 polyclonal hypergammaglobulinemia 9.8 MME IL6
48 peptic esophagitis 9.8 TNF IL6
49 idiopathic neutropenia 9.8 TNF IL6
50 irritant dermatitis 9.8 TNF IL6

Graphical network of the top 20 diseases related to Null-Cell Leukemia:



Diseases related to Null-Cell Leukemia

Symptoms & Phenotypes for Null-Cell Leukemia

MGI Mouse Phenotypes related to Null-Cell Leukemia:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 liver/biliary system MP:0005370 9.17 EMB IL6 LIF LTA MME PHYH

Drugs & Therapeutics for Null-Cell Leukemia

Search Clinical Trials , NIH Clinical Center for Null-Cell Leukemia

Genetic Tests for Null-Cell Leukemia

Anatomical Context for Null-Cell Leukemia

MalaCards organs/tissues related to Null-Cell Leukemia:

40
T Cells, B Cells, Bone Marrow, Bone, Monocytes

Publications for Null-Cell Leukemia

Articles related to Null-Cell Leukemia:

(show all 29)
# Title Authors PMID Year
1
Molecular analysis of a t(11;14)(q23;q11) from a patient with null-cell acute lymphoblastic leukemia. 61
7688554 1993
2
Initial characterization of a cytokine which induces differentiation and cytolytic activity in HL-60 promyelocytic leukemia cells: evidence that the cytokine is distinct from other known differentiation-active cytokines. 61
2152942 1990
3
P48 induces tumor necrosis factor and IL-1 secretion by human monocytes. 61
2809197 1989
4
Gene expression of terminal deoxynucleotidyl transferase in neoplastic cells of leukemia and lymphoma. 61
2501250 1989
5
Mesangiolytic glomerulopathy in a bone marrow allograft recipient. 61
2656494 1989
6
Synovial fluid involvement in null cell acute lymphoblastic leukemia diagnosed with monoclonal antibodies. 61
3164075 1988
7
The French-American-British (FAB) classification of leukemia. The Pediatric Oncology Group experience with lymphocytic leukemia. 61
3484662 1986
8
An analysis of the presence of Fc receptors on bone marrow lymphoblasts in acute lymphoblastic leukemia. A Pediatric Oncology Group study. 61
3875396 1985
9
[Leukemias]. 61
2937023 1985
10
Long-term relapse-free survival in adult acute lymphoblastic leukemia. 61
3855697 1985
11
Two new monoclonal antibodies (LN-1, LN-2) reactive in B5 formalin-fixed, paraffin-embedded tissues with follicular center and mantle zone human B lymphocytes and derived tumors. 61
6376628 1984
12
An Ia-like antigen positive null cell leukemia cell line (THP-5) lacking in the stimulating capacity in autologous and allogeneic mixed lymphocyte reaction. 61
6232734 1984
13
Heterogeneity of acute lymphocytic leukemia cell surface markers as detected by monoclonal antibodies. 61
6602900 1983
14
Clinical implications of glucocorticoid receptors in human leukemia. 61
6956240 1982
15
Immunoregulation by blasts from null cell and T-cell leukemias: help and suppression of T-cell proliferative responses to mitogens. 61
6459155 1982
16
Ataxia telangiectasia and acute lymphoblastic leukemia: report of a case. 61
6950588 1981
17
Adenosine deaminase activity in lymphoid subpopulations and leukemias. 61
6972803 1981
18
Cytogenetic abnormalities in a human null cell leukemia line (REH). 61
6942909 1981
19
Humoral helper activity for B-cell differentiation released from non-Hodgkin's lymphoma cells having both SRBC and complement receptors in the pokeweed mitogen system. 61
6971666 1981
20
Acute myeloblastic leukemia masquerading as null-cell acute lymphoblastic leukemia. 61
6938777 1981
21
Null-cell leukemia in course of T-cell lymphoma. 61
6970352 1981
22
Cell surface markers in acute lymphoblastic leukemia. 61
6967278 1980
23
Null cell (non-T, non-B) acute lymphoblastic leukemia terminating as malignant histiocytosis. 61
6929651 1980
24
A study of surface markers in acute lymphocytic leukemia by using anti-T and anti-B lymphocyte sera. 61
310335 1978
25
Helix pomatia A hemagglutinin: selectivity of binding to lymphocyte surface glycoproteins on T cells and certain B cells. 61
309819 1978
26
Correlation of adenosine deaminase activity with cell surface markers in acute lymphoblastic leukemia. 61
308513 1978
27
Characterization of a unique cell line (LAZ 221) from human acute lymphocytic ("null" cell) leukemia. 61
205365 1978
28
T and B lymphocyte antigen-positive null cell leukemias. 61
65190 1977
29
Establishment and characterization of leukemic T-cell lines, B-cell lines, and null-cell line: a progress report on surface antigen study of fresh lymphatic leukemias in man. 61
305398 1977

Variations for Null-Cell Leukemia

Expression for Null-Cell Leukemia

Search GEO for disease gene expression data for Null-Cell Leukemia.

Pathways for Null-Cell Leukemia

GO Terms for Null-Cell Leukemia

Biological processes related to Null-Cell Leukemia according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.85 TNF LTA LIF IL6
2 cytokine-mediated signaling pathway GO:0019221 9.67 TNF LIF IL6 IFNA1
3 defense response to Gram-positive bacterium GO:0050830 9.65 TNF LTA IL6
4 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.58 TNF LIF IL6
5 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.54 TNF IL6
6 positive regulation of peptidyl-serine phosphorylation of STAT protein GO:0033141 9.52 LIF IFNA1
7 positive regulation of chemokine production GO:0032722 9.51 TNF IL6
8 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.5 TNF LIF IL6
9 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.49 TNF IL6
10 positive regulation of neuroinflammatory response GO:0150078 9.46 TNF IL6
11 negative regulation of lipid storage GO:0010888 9.43 TNF IL6
12 positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0002925 9.26 TNF LTA
13 positive regulation of chronic inflammatory response to antigenic stimulus GO:0002876 9.16 TNF LTA
14 positive regulation of glial cell proliferation GO:0060252 9.13 TNF LTA IL6
15 humoral immune response GO:0006959 8.92 TNF LTA IL6 IFNA1

Molecular functions related to Null-Cell Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 TNF LTA LIF IL6 IFNA1

Sources for Null-Cell Leukemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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