Aliases & Classifications for Nut Allergy

MalaCards integrated aliases for Nut Allergy:

Name: Nut Allergy 12 75 15
Nut Allergic Reaction 12 17
Nut Hypersensitivity 44 72
Allergy to Nuts 12
Allergy Nut 55

Classifications:



External Ids:

Disease Ontology 12 DOID:4379
MeSH 44 D021184
SNOMED-CT 68 91934008
UMLS 72 C0577620

Summaries for Nut Allergy

Disease Ontology : 12 A food allergy that develops from exposure to and particularly consumption of nuts, and has symptom asthma, skin rashes, throat and eye irritation, and anaphylaxis.

MalaCards based summary : Nut Allergy, also known as nut allergic reaction, is related to ige responsiveness, atopic and dermatitis, and has symptoms including asthma An important gene associated with Nut Allergy is STAT6 (Signal Transducer And Activator Of Transcription 6), and among its related pathways/superpathways are Th17 cell differentiation and NF-kappaB Signaling. The drugs Cefpodoxime and tannic acid have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and testes, and related phenotypes are growth/size/body region and liver/biliary system

Wikipedia : 75 A tree nut allergy is a hypersensitivity to dietary substances from tree nuts and edible tree seeds... more...

Related Diseases for Nut Allergy

Diseases related to Nut Allergy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 71)
# Related Disease Score Top Affiliating Genes
1 ige responsiveness, atopic 30.3 STAT6 IL5 IL4
2 dermatitis 30.2 IL5 IL4 FLG
3 egg allergy 30.1 IQCE IL5 IL4
4 pollen allergy 29.8 IL5 FOXP3 ENPP3
5 allergic hypersensitivity disease 29.7 SCP2 IL5 IL4 ENPP3
6 asthma 29.4 STAT6 IL5 IL4 FLG
7 food allergy 28.8 STAT6 SCP2 IL5 IL4 FOXP3 FLG
8 dermatitis, atopic 28.4 STAT6 IL5 IL4 FOXP3 FLG
9 peanut allergy 11.7
10 exercise-induced anaphylaxis 10.6 FLG ENPP3
11 jak3-deficient severe combined immunodeficiency 10.4 STAT6 IL4
12 penicillin allergy 10.4 STAT6 IL4
13 beta-lactam allergy 10.3 STAT6 IL4
14 orofacial granulomatosis 10.2 IL4 FLG
15 nickel allergic contact dermatitis 10.2 IL5 IL4
16 cough variant asthma 10.2 IL5 IL4
17 scleritis 10.2 IL5 IL4
18 atopic keratoconjunctivitis 10.2 IL5 IL4
19 sulfamethoxazole allergy 10.2 IL5 IL4
20 inflammatory bowel disease 4 10.2 IL5 IL4
21 trichinosis 10.2 IL5 IL4
22 intrinsic asthma 10.2 IL5 IL4
23 angiostrongyliasis 10.2 IL5 IL4
24 gaucher disease, type ii 10.2 IL5 IL4
25 non-suppurative otitis media 10.1 IL5 IL4
26 eosinophilic meningitis 10.1 IL5 IL4
27 chronic conjunctivitis 10.1 IL5 IL4
28 filarial elephantiasis 10.1 IL5 IL4
29 chronic tic disorder 10.1 IL5 IL4
30 kimura disease 10.1 IL5 IL4
31 allergic rhinitis 10.1
32 exanthem 10.1
33 angioedema 10.1
34 toxic oil syndrome 10.1 IL5 IL4
35 vernal keratoconjunctivitis 10.1 IL5 IL4
36 folliculitis 10.1 IL5 IL4
37 enterobiasis 10.1 IL5 IL4
38 conjunctival disease 10.0 IL5 IL4
39 milk allergy 10.0 IL5 IL4
40 allergic bronchopulmonary aspergillosis 10.0 IL5 IL4
41 intestinal schistosomiasis 10.0 STAT6 IL5 IL4
42 schistosomiasis 10.0 STAT6 IL5 IL4
43 urinary schistosomiasis 10.0 STAT6 IL5 IL4
44 respiratory allergy 10.0 STAT6 IL5 IL4
45 latex allergy 10.0 IL5 IL4 FLG
46 bronchial disease 10.0 STAT6 IL5 IL4
47 allergic asthma 10.0 STAT6 IL5 IL4
48 nasal cavity disease 10.0 IL5 IL4 FLG
49 pulmonary eosinophilia 10.0 IL5 IL4
50 anxiety 9.9

Graphical network of the top 20 diseases related to Nut Allergy:



Diseases related to Nut Allergy

Symptoms & Phenotypes for Nut Allergy

Symptoms:

12
  • asthma

MGI Mouse Phenotypes related to Nut Allergy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.56 ENPP3 FOXP3 IL4 IL5 IQCE RRAGA
2 liver/biliary system MP:0005370 9.02 FOXP3 IL4 IL5 SCP2 STAT6

Drugs & Therapeutics for Nut Allergy

Drugs for Nut Allergy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cefpodoxime Approved, Vet_approved 80210-62-4, 82619-04-3 6335986
2
tannic acid Approved 1401-55-4
3
Benzocaine Approved, Investigational 94-09-7, 1994-09-7 2337
4 Cefpodoxime proxetil
5 Soy Bean

Interventional clinical trials:

(show all 19)
# Name Status NCT ID Phase Drugs
1 Walnut Oral Immunotherapy for Tree Nut Allergy Active, not recruiting NCT01546753 Phase 1, Phase 2 Walnut Protein Powder;Oat Powder (placebo)
2 Walnut Oral Immunotherapy for Tree Nut Allergy Withdrawn NCT01834352 Phase 1, Phase 2 Walnut Protein Flour;Oat flour
3 Trichuris Suis Ova Therapy for Mild to Moderate Peanut and Tree Nut Allergy in Adults and Children Completed NCT01070498 Phase 1 Trichuris suis ova (TSO)
4 Nut Allergy Study: Improving Diagnosis And Treatment Of Nut Allergy Completed NCT01502878
5 The Effect of Per Oral Immunotherapy in Severe IgE Mediated Egg, Milk and Nut Allergy in Adults Completed NCT01822353
6 Tree Nuts Allergies: Does a Single Nut Allergy Necessitate the Dietary Eviction? Completed NCT01744990
7 Potential Allergens in Wine: Double Blind Placebo-controlled Trial and Basophil Activation Analysis Completed NCT00163735 Administration of wine fined with potential food allergens
8 Visual Recognition of Allergens by Allergic Patients and/or Their Parents Completed NCT02966938
9 Phenotypical Characterization of Peanut Allergic Children With Differences in Cross-allergy to Tree Nuts and Other Legumes Completed NCT02961452
10 Mucosal Immunity of Ulcerative Colitis Patients Undergoing Therapy With Trichuris Suis Ova Completed NCT01433471 Trichuris suis ova
11 Trial To Reduce Food Allergy Anxiety by Holding the Allergen (TOUCH Study) Completed NCT03349047
12 Clinical and Biological Efficacy of Peanut Oral Immunotherapy Completed NCT02979600
13 Basophil Activation Test to Diagnose Food Allergy Recruiting NCT03309488
14 Peanut/Tree Nut Desensitization and Induction of Tolerance in Children Recruiting NCT03532360
15 Assessing Tolerance to "May Contain Traces" Processed Foods in Tree Nuts or Peanut Allergic Children. Recruiting NCT03680066
16 Nut Cross-Reactivity - ACuiring Knowledge for Elimination Recommendations (NUT-CRACKER) Study Recruiting NCT02786914
17 Blood Samples for the Study of Peanut, Tree Nut and Other Food Allergies Recruiting NCT02192866
18 Mixed Tree Nut Food Challenges Enrolling by invitation NCT02070263
19 Walnut Oral Immunotherapy for Tree Nut Allergy-CHOP Withdrawn NCT01918657 walnut powder;walnut powder

Search NIH Clinical Center for Nut Allergy

Cochrane evidence based reviews: nut hypersensitivity

Genetic Tests for Nut Allergy

Anatomical Context for Nut Allergy

MalaCards organs/tissues related to Nut Allergy:

41
Skin, Eye, Testes, Liver, B Cells

Publications for Nut Allergy

Articles related to Nut Allergy:

(show top 50) (show all 190)
# Title Authors PMID Year
1
Identification of common allergenic structures in hazel pollen and hazelnuts: a possible explanation for sensitivity to hazelnuts in patients allergic to tree pollen. 9 38
1281178 1992
2
Cashew Nut Allergy: Clinical Relevance and Allergen Characterisation. 38
27585580 2019
3
SPT predictive values for the outcome of cashew challenges in children. 38
31276826 2019
4
Pistachio and cashew nut allergy in childhood: Predictive factors towards development of a decision tree. 38
31310145 2019
5
Incidence, clinical features, and outcomes of food allergy in children who underwent liver transplant: 16-year experience. 38
30884056 2019
6
Walnut oral immunotherapy for desensitisation of walnut and additional tree nut allergies (Nut CRACKER): a single-centre, prospective cohort study. 38
30926371 2019
7
Effects of thermal treatment on walnut detection and allergenicity. 38
30324619 2019
8
Patterns of tree nut sensitization and allergy in the first 6 years of life in a population-based cohort. 38
30171872 2019
9
Clinical presentation of cashew nut allergy in a paediatric cohort attending an allergy clinic in the West of Ireland. 38
29623581 2019
10
An Approach to the Diagnostic Challenges of Tree Nut Allergy. 38
30973100 2019
11
Pistachio nut allergy: An updated overview. 38
28925724 2019
12
IgE Cross-Reactivity of Cashew Nut Allergens. 38
30368491 2019
13
Tree nut allergy and anxiety related factors modulate food consumption behaviour in peanut-allergic patients: Results of the MIRABEL survey. 38
30253193 2018
14
Almond Allergy: An Overview on Prevalence, Thresholds, Regulations and Allergen Detection. 38
30412996 2018
15
Asian children living in Australia have a different profile of allergy and anaphylaxis than Australian-born children: A State-wide survey. 38
30025179 2018
16
Tree nut allergens. 38
29680588 2018
17
Tree nut allergies: Allergen homology, cross-reactivity, and implications for therapy. 38
29700869 2018
18
Cashew nut allergy in Singaporean children. 38
30079307 2018
19
Threshold dose distribution for cashew nut allergy in children. 38
29671917 2018
20
Component-resolved diagnostics demonstrates that most peanut-allergic individuals could potentially introduce tree nuts to their diet. 38
29377469 2018
21
How to diagnose food allergy. 38
29601353 2018
22
Poly(anhydride) nanoparticles containing cashew nut proteins can induce a strong Th1 and Treg immune response after oral administration. 38
29428795 2018
23
Short-term ibrutinib therapy suppresses skin test responses and eliminates IgE-mediated basophil activation in adults with peanut or tree nut allergy. 38
29360526 2018
24
Pine nut allergy in Korean children: Clinical characteristics and diagnostic values of specific IgE against pine nuts. 38
29395441 2018
25
Self-reported adverse food reactions and anaphylaxis in the SchoolNuts study: A population-based study of adolescents. 38
29174346 2018
26
NUT Co Reactivity - ACquiring Knowledge for Elimination Recommendations (NUT CRACKER) study. 38
29127694 2018
27
Management of nut allergy in primary care. 38
29371317 2018
28
Current perspectives on tree nut allergy: a review. 38
29618933 2018
29
Preliminary psychometric analyses and clinical performance of a caregiver self-efficacy scale for food allergy self-management. 38
29273132 2018
30
First reported case in Canada of anaphylaxis to lupine in a child with peanut allergy. 38
30386385 2018
31
Recent advances in understanding and preventing peanut and tree nut hypersensitivity. 38
30467518 2018
32
Coconut Allergy Revisited. 38
28961189 2017
33
B-FAHF-2 plus oral immunotherapy (OIT) is safer and more effective than OIT alone in a murine model of concurrent peanut/tree nut allergy. 38
28397379 2017
34
Nut Allergy in Two Different Areas of Spain: Differences in Clinical and Molecular Pattern. 38
28825657 2017
35
Prediction of cashew nut allergy in sensitized children. 38
28423473 2017
36
Nut allergy guidelines discourage complete avoidance. 38
28584009 2017
37
Nut allergy guideline. 38
28574656 2017
38
BSACI guideline for the diagnosis and management of peanut and tree nut allergy. 38
28836701 2017
39
Managing Nut Allergy: A Remaining Clinical Challenge. 38
27793601 2017
40
Comparison of the Performance of Skin Prick, ImmunoCAP, and ISAC Tests in the Diagnosis of Patients with Allergy. 38
28456812 2017
41
sIgE Ana o 1, 2 and 3 accurately distinguish tolerant from allergic children sensitized to cashew nuts. 38
27513566 2017
42
Identification, characterization, and initial epitope mapping of pine nut allergen Pin k 2. 38
29195881 2016
43
Threshold dose distribution and eliciting dose of cashew nut allergy. 38
27773603 2016
44
Development of sesame tolerance and cosensitization of sesame allergy with peanut and tree nut allergy in children. 38
28073703 2016
45
Hazelnut Allergens: Molecular Characterization, Detection, and Clinical Relevance. 38
25751378 2016
46
Asymptomatic LTP sensitisation is common in plant-food allergic children from the Northeast of Spain. 38
27040809 2016
47
Does providing written dietary advice improve the ingestion of non-allergic nuts in children with existing nut allergies? - A randomized controlled trial. 38
26892074 2016
48
Cross-sensitization profiles of edible nuts in a birch-endemic area. 38
26706253 2016
49
Nut allergy prevalence and differences between Asian-born children and Australian-born children of Asian descent: a state-wide survey of children at primary school entry in Victoria, Australia. 38
26728850 2016
50
Cor a 14 is the superior serological marker for hazelnut allergy in children, independent of concomitant peanut allergy. 38
26666993 2016

Variations for Nut Allergy

Expression for Nut Allergy

Search GEO for disease gene expression data for Nut Allergy.

Pathways for Nut Allergy

GO Terms for Nut Allergy

Biological processes related to Nut Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of B cell proliferation GO:0030890 8.96 IL5 IL4
2 positive regulation of isotype switching to IgE isotypes GO:0048295 8.62 STAT6 IL4

Molecular functions related to Nut Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.36 TNS1 STAT6 SCP2 RRAGA LCOR KCTD1

Sources for Nut Allergy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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