Aliases & Classifications for Nut Allergy

MalaCards integrated aliases for Nut Allergy:

Name: Nut Allergy 12 74 15
Nut Allergic Reaction 12 17
Nut Hypersensitivity 43 71
Allergy to Nuts 12
Allergy Nut 54

Classifications:



External Ids:

Disease Ontology 12 DOID:4379
MeSH 43 D021184
SNOMED-CT 67 91934008
UMLS 71 C0577620

Summaries for Nut Allergy

Disease Ontology : 12 A food allergy that develops from exposure to and particularly consumption of nuts, and has symptom asthma, skin rashes, throat and eye irritation, and anaphylaxis.

MalaCards based summary : Nut Allergy, also known as nut allergic reaction, is related to peanut allergy and allergic rhinitis, and has symptoms including asthma An important gene associated with Nut Allergy is STAT6 (Signal Transducer And Activator Of Transcription 6), and among its related pathways/superpathways are Interleukin-4 and 13 signaling and Innate Lymphoid Cells Differentiation. The drugs Cefpodoxime and tannic acid have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and testes, and related phenotype is immune system.

Wikipedia : 74 A tree nut allergy is a hypersensitivity to dietary substances from tree nuts and edible tree seeds... more...

Related Diseases for Nut Allergy

Diseases related to Nut Allergy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 138)
# Related Disease Score Top Affiliating Genes
1 peanut allergy 30.2 PEDS1 PDCL IL5 IL13 IGHE FLG
2 allergic rhinitis 29.2 IL5 IL13 IGHE IGES
3 ige responsiveness, atopic 29.1 STAT6 IL5 IL13 IGHE IGES
4 urticaria 29.0 IL5 IL13 IGHE ENPP3
5 allergic hypersensitivity disease 28.9 PEDS1 IL5 IL13 IGHE CCR6
6 dermatitis 28.9 IL5 IL13 IGHE FLG CCR6
7 rhinitis 28.8 IL5 IL13 IGHE FLG
8 food allergy 28.4 STAT6 SCP2 IL5 IL13 IGHE IGES
9 asthma 27.9 STAT6 IL5 IL13 IGHE IGES FLG
10 egg allergy 27.6 PEDS1 PDCL IL5 IL13 IGHE FLG
11 dermatitis, atopic 27.5 STAT6 PEDS1 IL5 IL13 IGHE IGES
12 pollen allergy 27.3 SCP2 PEDS1 PDCL IL5 IL13 IGHE
13 apricot allergy 10.4 PEDS1 ENPP3
14 chlorhexidine allergy 10.4 PEDS1 ENPP3
15 co-trimoxazole allergy 10.4 STAT6 ENPP3
16 cephalosporin allergy 10.4 PEDS1 ENPP3
17 crustacean allergy 10.3 PEDS1 CCR6
18 shrimp allergy 10.3 PEDS1 CCR6
19 vernal conjunctivitis 10.3 IGHE CCR6
20 celery allergy 10.3 SCP2 PEDS1
21 cherry allergy 10.3 SCP2 IGHE
22 timothy grass allergy 10.2 PEDS1 PDCL
23 low-grade astrocytoma 10.2 STAT6 IL13
24 breast implant-associated anaplastic large cell lymphoma 10.2 IL13 CCR6
25 melon allergy 10.2 PDCL ENPP3
26 scabies 10.1 FLG CCR6
27 rocuronium allergy 10.1 PEDS1 CD63
28 diclofenac allergy 10.1 ENPP3 CD63
29 dacryoadenitis 10.1 IL13 CCR6
30 seborrheic dermatitis 10.1 FLG CCR6
31 physical urticaria 10.1 ENPP3 CD63
32 exanthem 10.1
33 angioedema 10.1
34 eczema herpeticum 10.1 FLG CCR6
35 neurogenic bladder 10.1 IGHE IGES
36 carbapenem allergy 10.1 STAT6 IL13 ENPP3
37 exercise-induced anaphylaxis 10.1 IGHE FLG ENPP3
38 penicillin allergy 10.0 STAT6 IL13 IGHE
39 lymphoma, hodgkin, classic 10.0 STAT6 IL13 CCR6
40 fish allergy 10.0 PEDS1 PDCL IGHE
41 oxirane allergy 10.0 PEDS1 ENPP3 CD63
42 anxiety 10.0
43 helix syndrome 10.0
44 amoxicillin allergy 9.9 IGHE ENPP3 CD63
45 atopic keratoconjunctivitis 9.9 IL5 IGHE
46 vegetable allergy 9.9 SCP2 PEDS1 PDCL
47 apple allergy 9.9 SCP2 PEDS1 PDCL
48 toxic oil syndrome 9.9 IL5 IGHE
49 pustulosis palmaris et plantaris 9.9 IL5 CCR6
50 toxocariasis 9.9 IL5 IGHE

Graphical network of the top 20 diseases related to Nut Allergy:



Diseases related to Nut Allergy

Symptoms & Phenotypes for Nut Allergy

Symptoms:

12
  • asthma

MGI Mouse Phenotypes related to Nut Allergy:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.23 CCR6 ENPP3 IL13 IL5 NUTM1 PEDS1

Drugs & Therapeutics for Nut Allergy

Drugs for Nut Allergy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cefpodoxime Approved, Vet_approved 80210-62-4, 82619-04-3 6335986
2
tannic acid Approved 1401-55-4
3
Benzocaine Approved, Investigational 94-09-7, 1994-09-7 2337
4 Cefpodoxime proxetil
5 Soy Bean
6 Anti-Bacterial Agents
7 Anti-Infective Agents

Interventional clinical trials:

(show all 21)
# Name Status NCT ID Phase Drugs
1 Walnut Oral Immunotherapy for Tree Nut Allergy Active, not recruiting NCT01546753 Phase 1, Phase 2 Walnut Protein Powder;Oat Powder (placebo)
2 Walnut Oral Immunotherapy for Tree Nut Allergy Withdrawn NCT01834352 Phase 1, Phase 2 Walnut Protein Flour;Oat flour
3 Trichuris Suis Ova Therapy for Mild to Moderate Peanut and Tree Nut Allergy in Adults and Children Completed NCT01070498 Phase 1 Trichuris suis ova (TSO)
4 Nut Cross-Reactivity - ACuiring Knowledge for Elimination Recommendations (NUT-CRACKER) Study Unknown status NCT02786914
5 Nut Allergy Study: Improving Diagnosis And Treatment Of Nut Allergy Completed NCT01502878
6 The Effect of Per Oral Immunotherapy in Severe IgE Mediated Egg, Milk and Nut Allergy in Adults Completed NCT01822353
7 Tree Nuts Allergies: Does a Single Nut Allergy Necessitate the Dietary Eviction? Completed NCT01744990
8 Potential Allergens in Wine: Double Blind Placebo-controlled Trial and Basophil Activation Analysis Completed NCT00163735 Administration of wine fined with potential food allergens
9 Visual Recognition of Allergens by Allergic Patients and/or Their Parents Completed NCT02966938
10 Phenotypical Characterization of Peanut Allergic Children With Differences in Cross-allergy to Tree Nuts and Other Legumes Completed NCT02961452
11 Mucosal Immunity of Ulcerative Colitis Patients Undergoing Therapy With Trichuris Suis Ova Completed NCT01433471 Trichuris suis ova
12 Evaluating the Correlation Between the Results of the Allergy Work-up for Different Allergens of the Anacardiaceae Family Completed NCT04304586
13 Trial To Reduce Food Allergy Anxiety by Holding the Allergen (TOUCH Study) Completed NCT03349047
14 Clinical and Biological Efficacy of Peanut Oral Immunotherapy Completed NCT02979600
15 Basophil Activation Test to Diagnose Food Allergy Recruiting NCT03309488
16 Comparison of Protocols for Re-introducing Tree Nuts in Patients With Allergy to Tree Nuts Recruiting NCT04151069
17 Peanut/Tree Nut Desensitization and Induction of Tolerance in Children Recruiting NCT03532360
18 Assessing Tolerance to "May Contain Traces" Processed Foods in Tree Nuts or Peanut Allergic Children. Recruiting NCT03680066
19 Blood Samples for the Study of Peanut, Tree Nut and Other Food Allergies Recruiting NCT02192866
20 Mixed Tree Nut Food Challenges Enrolling by invitation NCT02070263
21 Walnut Oral Immunotherapy for Tree Nut Allergy-CHOP Withdrawn NCT01918657 walnut powder;walnut powder

Search NIH Clinical Center for Nut Allergy

Cochrane evidence based reviews: nut hypersensitivity

Genetic Tests for Nut Allergy

Anatomical Context for Nut Allergy

MalaCards organs/tissues related to Nut Allergy:

40
Skin, Eye, Testes, Liver, B Cells

Publications for Nut Allergy

Articles related to Nut Allergy:

(show top 50) (show all 197)
# Title Authors PMID Year
1
Identification of common allergenic structures in hazel pollen and hazelnuts: a possible explanation for sensitivity to hazelnuts in patients allergic to tree pollen. 61 54
1281178 1992
2
Prevalence and natural history of tree nut allergy. 61
32044450 2020
3
Co-sensitization to the fruit seeds and raw potato in children with cashew nut allergy. 61
32278325 2020
4
Children with nut allergies have impaired gene expression of Toll-like receptors pathway. 61
32173911 2020
5
The predominance of seafood allergy in Vietnamese adults: Results from the first population-based questionnaire survey. 61
32161634 2020
6
Real-world tree nut consumption in peanut-allergic individuals. 61
31805359 2020
7
IgE cross-reactivity measurement of cashew nut, hazelnut and peanut using a novel IMMULITE inhibition method. 61
32083439 2020
8
The influence of cultural attitudes to nut exposure on reported nut allergy: A pilot cross sectional study. 61
32559218 2020
9
Skin Prick Test Predictive Values for the Outcome of Cashew Challenges in Children. 61
31276826 2020
10
Cashew Nut Allergy: Clinical Relevance and Allergen Characterisation. 61
27585580 2019
11
Pistachio and cashew nut allergy in childhood: Predictive factors towards development of a decision tree. 61
31310145 2019
12
Incidence, clinical features, and outcomes of food allergy in children who underwent liver transplant: 16-year experience. 61
30884056 2019
13
Walnut oral immunotherapy for desensitisation of walnut and additional tree nut allergies (Nut CRACKER): a single-centre, prospective cohort study. 61
30926371 2019
14
Effects of thermal treatment on walnut detection and allergenicity. 61
30324619 2019
15
Patterns of tree nut sensitization and allergy in the first 6 years of life in a population-based cohort. 61
30171872 2019
16
Clinical presentation of cashew nut allergy in a paediatric cohort attending an allergy clinic in the West of Ireland. 61
29623581 2019
17
Pistachio nut allergy: An updated overview. 61
28925724 2019
18
An Approach to the Diagnostic Challenges of Tree Nut Allergy. 61
30973100 2019
19
IgE Cross-Reactivity of Cashew Nut Allergens. 61
30368491 2019
20
Tree nut allergy and anxiety related factors modulate food consumption behaviour in peanut-allergic patients: Results of the MIRABEL survey. 61
30253193 2018
21
Almond Allergy: An Overview on Prevalence, Thresholds, Regulations and Allergen Detection. 61
30412996 2018
22
Asian children living in Australia have a different profile of allergy and anaphylaxis than Australian-born children: A State-wide survey. 61
30025179 2018
23
Tree nut allergens. 61
29680588 2018
24
Tree nut allergies: Allergen homology, cross-reactivity, and implications for therapy. 61
29700869 2018
25
Cashew nut allergy in Singaporean children. 61
30079307 2018
26
Threshold dose distribution for cashew nut allergy in children. 61
29671917 2018
27
Component-resolved diagnostics demonstrates that most peanut-allergic individuals could potentially introduce tree nuts to their diet. 61
29377469 2018
28
How to diagnose food allergy. 61
29601353 2018
29
Poly(anhydride) nanoparticles containing cashew nut proteins can induce a strong Th1 and Treg immune response after oral administration. 61
29428795 2018
30
Short-term ibrutinib therapy suppresses skin test responses and eliminates IgE-mediated basophil activation in adults with peanut or tree nut allergy. 61
29360526 2018
31
Pine nut allergy in Korean children: Clinical characteristics and diagnostic values of specific IgE against pine nuts. 61
29395441 2018
32
Self-reported adverse food reactions and anaphylaxis in the SchoolNuts study: A population-based study of adolescents. 61
29174346 2018
33
NUT Co Reactivity - ACquiring Knowledge for Elimination Recommendations (NUT CRACKER) study. 61
29127694 2018
34
Management of nut allergy in primary care. 61
29371317 2018
35
Current perspectives on tree nut allergy: a review. 61
29618933 2018
36
Preliminary psychometric analyses and clinical performance of a caregiver self-efficacy scale for food allergy self-management. 61
29273132 2018
37
First reported case in Canada of anaphylaxis to lupine in a child with peanut allergy. 61
30386385 2018
38
Recent advances in understanding and preventing peanut and tree nut hypersensitivity. 61
30467518 2018
39
Coconut Allergy Revisited. 61
28961189 2017
40
B-FAHF-2 plus oral immunotherapy (OIT) is safer and more effective than OIT alone in a murine model of concurrent peanut/tree nut allergy. 61
28397379 2017
41
Nut Allergy in Two Different Areas of Spain: Differences in Clinical and Molecular Pattern. 61
28825657 2017
42
Prediction of cashew nut allergy in sensitized children. 61
28423473 2017
43
Nut allergy guidelines discourage complete avoidance. 61
28584009 2017
44
Nut allergy guideline. 61
28574656 2017
45
BSACI guideline for the diagnosis and management of peanut and tree nut allergy. 61
28836701 2017
46
Managing Nut Allergy: A Remaining Clinical Challenge. 61
27793601 2017
47
Comparison of the Performance of Skin Prick, ImmunoCAP, and ISAC Tests in the Diagnosis of Patients with Allergy. 61
28456812 2017
48
sIgE Ana o 1, 2 and 3 accurately distinguish tolerant from allergic children sensitized to cashew nuts. 61
27513566 2017
49
Identification, characterization, and initial epitope mapping of pine nut allergen Pin k 2. 61
29195881 2016
50
Threshold dose distribution and eliciting dose of cashew nut allergy. 61
27773603 2016

Variations for Nut Allergy

Expression for Nut Allergy

Search GEO for disease gene expression data for Nut Allergy.

Pathways for Nut Allergy

GO Terms for Nut Allergy

Cellular components related to Nut Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.92 IL13 IGHE ENPP3 CCR6

Biological processes related to Nut Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.26 IL5 IL13 IGHE CCR6
2 cytokine-mediated signaling pathway GO:0019221 8.92 STAT6 IL5 IL13 IGHE

Sources for Nut Allergy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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