Aliases & Classifications for Nut Allergy

MalaCards integrated aliases for Nut Allergy:

Name: Nut Allergy 12 76 15
Nut Hypersensitivity 44 73
Nut Allergic Reaction 12
Allergy to Nuts 12
Allergy Nut 55

Classifications:



External Ids:

Disease Ontology 12 DOID:4379
MeSH 44 D021184
SNOMED-CT 68 91934008
UMLS 73 C0577620

Summaries for Nut Allergy

MalaCards based summary : Nut Allergy, also known as nut hypersensitivity, is related to egg allergy and allergic hypersensitivity disease. An important gene associated with Nut Allergy is STAT6 (Signal Transducer And Activator Of Transcription 6), and among its related pathways/superpathways are NF-kappaB Signaling and Th2 Differentiation Pathway. The drugs English walnut and Cefpodoxime have been mentioned in the context of this disorder. Affiliated tissues include testes, skin and liver, and related phenotypes are homeostasis/metabolism and immune system

Wikipedia : 76 A tree nut allergy is a hypersensitivity to dietary substances from tree nuts and edible tree seeds... more...

Related Diseases for Nut Allergy

Diseases related to Nut Allergy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 46)
# Related Disease Score Top Affiliating Genes
1 egg allergy 30.1 IL5 IQCE
2 allergic hypersensitivity disease 29.6 ENPP3 IL5 SCP2 TLR9
3 asthma 29.4 FLG IL5 PTGDR2 STAT6 TLR9
4 peanut allergy 11.2
5 exercise-induced anaphylaxis 10.2 ENPP3 FLG
6 intestinal schistosomiasis 10.1 IL5 STAT6
7 urinary schistosomiasis 10.1 IL5 STAT6
8 filarial elephantiasis 10.1 IL5 TLR9
9 anxiety 10.1
10 latex allergy 10.1 FLG IL5
11 stevens-johnson syndrome/toxic epidermal necrolysis 10.1 IL5 TLR9
12 ige responsiveness, atopic 10.1 IL5 STAT6
13 common cold 10.1 IL5 TLR9
14 autoimmune disease of eyes, ear, nose and throat 10.1 FOXP3 TLR9
15 parasitic helminthiasis infectious disease 10.1 IL5 TLR9
16 filariasis 10.0 IL5 TLR9
17 mikulicz disease 10.0 IL5 PTGDR2
18 keratoconjunctivitis 10.0 IL5 TLR9
19 respiratory allergy 10.0 IL5 STAT6 TLR9
20 bronchial disease 10.0 IL5 STAT6 TLR9
21 folliculitis 10.0 IL5 PTGDR2
22 esophagitis, eosinophilic, 1 10.0 FLG IL5 STAT6
23 dermatitis 10.0 FLG IL5 TLR9
24 allergic conjunctivitis 10.0 IL5 PTGDR2
25 eosinophilic gastritis 10.0 FOXP3 IL5
26 autoimmune disease of musculoskeletal system 10.0 FOXP3 TLR9
27 pollen allergy 10.0 FOXP3 IL5
28 autoimmune disease of central nervous system 10.0 FOXP3 TLR9
29 yellow fever 10.0 IL5 SCP2 TLR9
30 allergic contact dermatitis 10.0 FLG IL5
31 lichen disease 10.0 FLG FOXP3 TLR9
32 skin disease 9.9 FLG IL5 TLR9
33 nose disease 9.9 IL5 PTGDR2 TLR9
34 contact dermatitis 9.9 FLG IL5
35 cutaneous leishmaniasis 9.9 FOXP3 IL5 TLR9
36 leishmaniasis 9.9 FOXP3 IL5 TLR9
37 immune system disease 9.9 FOXP3 IL5 TLR9
38 common variable immunodeficiency 9.9 FOXP3 IL5 TLR9
39 autoimmune disease 9.9 FOXP3 IL5 TLR9
40 apple allergy 9.9 FOXP3 IL5 SCP2
41 autoimmune disease of the nervous system 9.8 FOXP3 TLR9
42 nasal cavity disease 9.8 FLG IL5 PTGDR2 TLR9
43 inflammatory bowel disease 9.7 FOXP3 IL5 STAT6 TLR9
44 upper respiratory tract disease 9.7 FOXP3 IL5 PTGDR2 TLR9
45 food allergy 9.6 FLG FOXP3 IL5 SCP2 STAT6
46 dermatitis, atopic 9.5 FLG FOXP3 IL5 PTGDR2 STAT6 TLR9

Graphical network of the top 20 diseases related to Nut Allergy:



Diseases related to Nut Allergy

Symptoms & Phenotypes for Nut Allergy

MGI Mouse Phenotypes related to Nut Allergy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.56 FOXP3 IL5 IQCE PTGDR2 RRAGA SCP2
2 immune system MP:0005387 9.23 ENPP3 FOXP3 IL5 PTGDR2 SCP2 STAT6

Drugs & Therapeutics for Nut Allergy

Drugs for Nut Allergy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 English walnut Approved Phase 1, Phase 2,Phase 2,Not Applicable
2
Cefpodoxime Approved, Vet_approved Not Applicable 82619-04-3, 80210-62-4 6335986
3 tannic acid Approved Not Applicable
4
Benzocaine Approved, Investigational Not Applicable 94-09-7, 1994-09-7 2337
5 Cefpodoxime proxetil Not Applicable
6 Soy Bean Not Applicable

Interventional clinical trials:

(show all 18)
# Name Status NCT ID Phase Drugs
1 Walnut Oral Immunotherapy for Tree Nut Allergy Active, not recruiting NCT01546753 Phase 1, Phase 2 Walnut Protein Powder;Oat Powder (placebo)
2 Walnut Oral Immunotherapy for Tree Nut Allergy Withdrawn NCT01834352 Phase 1, Phase 2 Walnut Protein Flour;Oat flour
3 Trichuris Suis Ova in Peanut and Tree Nut Allergy Completed NCT01070498 Phase 1 Trichuris suis ova (TSO)
4 Tree Nuts Allergies: Does a Single Nut Allergy Necessitate the Dietary Eviction of Other Tree Nuts? Completed NCT01744990 Not Applicable
5 Nut Allergy Study: Double-blind Challenge and Oral Desensitization Completed NCT01502878 Not Applicable
6 Visual Recognition of Allergens by Allergic Patients and/or Their Parents Completed NCT02966938
7 Phenotypical Characterization of Peanut Allergic Children Completed NCT02961452
8 Immunologic Profile of Children With Severe Allergies to Peanuts and Nuts After Induction of Tolerance Completed NCT01996774
9 One-year Survey of Anaphylaxis in Outpatient Children Allergic to Peanuts, Walnuts/Hazelnuts, Shellfish Completed NCT02640560
10 Potential Allergens in Wine: Double-blind Placebo-controlled Trial Completed NCT00163735 Not Applicable Administration of wine fined with potential food allergens
11 Peanut and Tree Nut Desensitization Recruiting NCT03532360 Not Applicable
12 Study to Assess Tolerance of Traces in Peanut/Tree Nut Allergic Children. Recruiting NCT03680066 Not Applicable
13 Blood Samples for the Study of Peanut, Tree Nut and Other Food Allergies Recruiting NCT02192866
14 Anxiety About Casual Exposure to Food Allergens Recruiting NCT03349047 Not Applicable
15 Basophil Activation Test to Diagnose Food Allergy Recruiting NCT03309488
16 The Effect of Per Oral Immunotherapy in Severe IgE Mediated Egg, Milk, and Nut Allergy in Adults Active, not recruiting NCT01822353 Not Applicable
17 Mixed Tree Nut Food Challenges Enrolling by invitation NCT02070263
18 Walnut Oral Immunotherapy for Tree Nut Allergy Withdrawn NCT01918657 Not Applicable walnut powder;walnut powder

Search NIH Clinical Center for Nut Allergy

Cochrane evidence based reviews: nut hypersensitivity

Genetic Tests for Nut Allergy

Anatomical Context for Nut Allergy

MalaCards organs/tissues related to Nut Allergy:

41
Testes, Skin, Liver, B Cells, Eye

Publications for Nut Allergy

Articles related to Nut Allergy:

(show top 50) (show all 95)
# Title Authors Year
1
Pine nut allergy in Korean children: Clinical characteristics and diagnostic values of specific IgE against pine nuts. ( 29395441 )
2018
2
Current perspectives on tree nut allergy: a review. ( 29618933 )
2018
3
Management of nut allergy in primary care. ( 29371317 )
2018
4
Short term ibrutinib therapy suppresses skin test responses and eliminates IgE-mediated basophil activation in adults with peanut or tree nut allergy. ( 29360526 )
2018
5
Threshold dose distribution for cashew nut allergy in children. ( 29671917 )
2018
6
Clinical presentation of cashew nut allergy in a paediatric cohort attending an allergy clinic in the West of Ireland. ( 29623581 )
2018
7
Tree nut allergy and anxiety related factors modulate food consumption behaviour in peanut-allergic patients: Results of the MIRABEL survey. ( 30253193 )
2018
8
Cashew nut allergy in Singaporean children. ( 30079307 )
2018
9
Recent advances in understanding and preventing peanut and tree nut hypersensitivity. ( 30467518 )
2018
10
Nut Allergy in Two Different Areas of Spain: Differences in Clinical and Molecular Pattern. ( 28825657 )
2017
11
Nut allergy guideline. ( 28574656 )
2017
12
Prediction of cashew nut allergy in sensitized children. ( 28423473 )
2017
13
B-FAHF-2 plus oral immunotherapy (OIT) is safer and more effective than OIT alone in a murine model of concurrent peanut/tree nut allergy. ( 28397379 )
2017
14
BSACI guideline for the diagnosis and management of peanut and tree nut allergy. ( 28836701 )
2017
15
Nut allergy guidelines discourage complete avoidance. ( 28584009 )
2017
16
Pistachio nut allergy: An updated overview. ( 28925724 )
2017
17
Managing Nut Allergy: A Remaining Clinical Challenge. ( 27793601 )
2016
18
Nut allergy prevalence and differences between Asian-born children and Australian-born children of Asian descent: a state-wide survey of children at primary school entry in Victoria, Australia. ( 26728850 )
2016
19
Cashew Nut Allergy: Clinical Relevance and Allergen Characterisation. ( 27585580 )
2016
20
Is Microarray Analysis Really Useful and Sufficient to Diagnose Nut Allergy in the Mediterranean Area? ( 27012014 )
2016
21
Development of sesame tolerance and cosensitization of sesame allergy with peanut and tree nut allergy in children. ( 28073703 )
2016
22
Specific IgE to recombinant protein (Ber e 1) for the diagnosis of Brazil nut allergy. ( 26684696 )
2016
23
Threshold dose distribution and eliciting dose of cashew nut allergy. ( 27773603 )
2016
24
A retrospective study of peanut and tree nut allergy: Sensitization and correlations with clinical manifestations. ( 25860169 )
2015
25
Peanut and tree nut allergy. ( 26022873 )
2015
26
Tree nut allergy: risk factors for development, mitigation of reaction risk and current efforts in desensitization. ( 25824522 )
2015
27
Dietary management of peanut and tree nut allergy: what exactly should patients avoid? ( 25443673 )
2015
28
High consumption of peanuts or tree nuts by non-allergic mothers around the time of pregnancy reduces the risk of nut allergy in the child. ( 24986044 )
2015
29
Cardiac mMCP-4+ mast cell expansion and elevation of IL-6, and CCR1/3 and CXCR2 signaling chemokines in an adjuvant-free mouse model of tree nut allergy. ( 25499102 )
2015
30
Oral immunotherapy initiation for multi-nut allergy: a case report. ( 25838098 )
2015
31
Usefulness of open mixed nut challenges to exclude tree nut allergy in children. ( 26034579 )
2015
32
A retrospective study of peanut and tree nut allergy: Sensitization and correlations with clinical manifestations. ( 25730137 )
2015
33
The Prevalence of Tree Nut Allergy: A Systematic Review. ( 26233427 )
2015
34
Particularities in a Child With Cashew Nut Allergy. ( 27335909 )
2014
35
Prospective study of peripregnancy consumption of peanuts or tree nuts by mothers and the risk of peanut or tree nut allergy in their offspring. ( 24366539 )
2014
36
Systematic review on cashew nut allergy. ( 24734868 )
2014
37
Identification of T- and B-Cell Subsets That Expand in the Central and Peripheral Lymphoid Organs during the Establishment of Nut Allergy in an Adjuvant-Free Mouse Model. ( 23724246 )
2013
38
"Dude! You mean you've never eaten a peanut butter and jelly sandwich?!?" Nut allergy as stigma in comic books. ( 22574889 )
2013
39
Lipids are required for the development of Brazil nut allergy: the role of mouse and human iNKT cells. ( 23137012 )
2013
40
Infant Feeding Practices and Nut Allergy over Time in Australian School Entrant Children. ( 22811733 )
2012
41
Pine nut allergy: clinical features and major allergens characterization. ( 23081934 )
2012
42
The psychological impact of diagnostic food challenges to confirm the resolution of peanut or tree nut allergy. ( 22093150 )
2012
43
Tree nut allergy, egg allergy, and asthma in children. ( 21098525 )
2011
44
Basophil CD203c levels are increased at baseline and can be used to monitor omalizumab treatment in subjects with nut allergy. ( 20975283 )
2011
45
A qualitative study of families of a child with a nut allergy. ( 21846662 )
2011
46
Management of nut allergy influences quality of life and anxiety in children and their mothers. ( 20088863 )
2010
47
Macadamia nut allergy: potentially misleading specific IgE results. ( 20337625 )
2010
48
Macadamia nut allergy: 2 case reports and a review of the literature. ( 20491364 )
2010
49
How do we know when peanut and tree nut allergy have resolved, and how do we keep it resolved? ( 20645999 )
2010
50
Characterizing the relationship between sesame, coconut, and nut allergy in children. ( 21073539 )
2010

Variations for Nut Allergy

Expression for Nut Allergy

Search GEO for disease gene expression data for Nut Allergy.

Pathways for Nut Allergy

Pathways related to Nut Allergy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.77 ENPP3 FOXP3 STAT6 TLR9
2 10.46 FOXP3 IL5 STAT6

GO Terms for Nut Allergy

Biological processes related to Nut Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of B cell proliferation GO:0030890 9.16 IL5 TLR9
2 negative regulation of interleukin-6 production GO:0032715 8.96 FOXP3 TLR9
3 immune response GO:0006955 8.92 ENPP3 IL5 PTGDR2 TLR9

Sources for Nut Allergy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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