Aliases & Classifications for Nut Allergy

MalaCards integrated aliases for Nut Allergy:

Name: Nut Allergy 12 74 15
Nut Allergic Reaction 12 17
Nut Hypersensitivity 43 71
Allergy to Nuts 12
Allergy Nut 54

Classifications:



External Ids:

Disease Ontology 12 DOID:4379
MeSH 43 D021184
SNOMED-CT 67 91934008
UMLS 71 C0577620

Summaries for Nut Allergy

Disease Ontology : 12 A food allergy that develops from exposure to and particularly consumption of nuts, and has symptom asthma, skin rashes, throat and eye irritation, and anaphylaxis.

MalaCards based summary : Nut Allergy, also known as nut allergic reaction, is related to peanut allergy and urticaria, and has symptoms including asthma An important gene associated with Nut Allergy is ENPP3 (Ectonucleotide Pyrophosphatase/Phosphodiesterase 3), and among its related pathways/superpathways are Akt Signaling and Cytokine Signaling in Immune system. The drugs Cefpodoxime and tannic acid have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and b cells, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 74 A tree nut allergy is a hypersensitivity to dietary substances from tree nuts and edible tree seeds... more...

Related Diseases for Nut Allergy

Diseases related to Nut Allergy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 330)
# Related Disease Score Top Affiliating Genes
1 peanut allergy 30.6 TMEM189 LCOR IL5 IL4 IL13 IL10
2 urticaria 29.9 IL5 IL4 IL13 IGHE ENPP3
3 exanthem 29.4 IL10 ICOSLG CD4 CCR6
4 allergic rhinitis 29.1 IL5 IL4 IL13 IL10 IGHE IGES
5 ige responsiveness, atopic 29.1 STAT6 IL5 IL4 IL13 IL10 IGHE
6 pollen allergy 28.8 TMEM189 SCP2 PDCL IL5 IL13 FOXP3
7 food allergy 28.3 STAT6 SCP2 IL5 IL4 IL13 IL10
8 dermatitis 28.1 TSLP IL5 IL4 IL13 IL10 IGHE
9 rhinitis 27.7 TSLP IL5 IL4 IL13 IL10 IGHE
10 egg allergy 27.4 TMEM189 PDCL IL5 IL4 IL10 IGHE
11 asthma 26.3 TSLP STAT6 IL5 IL4 IL13 IL10
12 allergic hypersensitivity disease 25.9 TSLP STAT6 SCP2 IL5 IL4 IL13
13 dermatitis, atopic 24.9 TSLP TMEM189 STAT6 PDCL IL5 IL4
14 apricot allergy 10.5 TMEM189 ENPP3
15 rocuronium allergy 10.5 TMEM189 CD63
16 cytokine deficiency 10.5 IL5 IL13
17 aztreonam allergy 10.5 IL5 IL13
18 carbapenem allergy 10.4 STAT6 IL13 ENPP3
19 co-trimoxazole allergy 10.4 STAT6 IL13 ENPP3
20 ceftriaxone allergy 10.4 IL5 IL13
21 shrimp allergy 10.4 TMEM189 CCR6
22 angioimmunoblastic lymphadenopathy with dysproteinemia 10.4 IL5 IL13
23 exercise-induced anaphylaxis 10.4 IGHE FLG ENPP3
24 respiratory syncytial virus infectious disease 10.4 IL5 IL13
25 cherry allergy 10.4 SCP2 IGHE
26 jak3-deficient severe combined immunodeficiency 10.4 STAT6 IL4
27 cefuroxime allergy 10.4 IL5 IL13
28 oxirane allergy 10.4 TMEM189 ENPP3 CD63
29 diclofenac allergy 10.4 ENPP3 CD63
30 loeffler syndrome 10.4 IL5 IL13
31 crustacean allergy 10.3 TMEM189 CCR6
32 dermatitis, atopic, 3 10.3 TSLP FLG
33 amoxicillin allergy 10.3 IGHE ENPP3 CD63
34 scleritis 10.3 IL5 IL4 CCR6
35 vernal conjunctivitis 10.3 IL4 IGHE CCR6
36 hyper ige syndrome 10.3 IL4 IGHE IGES
37 idiopathic nephrotic syndrome 10.3 IL4 IGHE
38 paragonimiasis 10.3 IL5 IL13 IGHE
39 timothy grass allergy 10.3 TMEM189 PDCL
40 atopic keratoconjunctivitis 10.3 IL5 IL4 IGHE
41 cefaclor allergy 10.3 IL5 IL13 CD63
42 angiostrongyliasis 10.3 IL5 IL4 IL13
43 eczema herpeticum 10.3 TSLP FLG CCR6
44 toxic oil syndrome 10.3 IL5 IL4 IGHE
45 cough variant asthma 10.3 IL5 IL4 IGHE
46 chronic rhinitis 10.3 IL5 IL4 IL13
47 aneruptive fever 10.3 IL13 FOXP3
48 eosinophilic pneumonia 10.3 IL5 IL4 IL13
49 pulmonary eosinophilia 10.2 IL5 IL4 IL13
50 irritant dermatitis 10.2 TSLP IL4 FLG

Graphical network of the top 20 diseases related to Nut Allergy:



Diseases related to Nut Allergy

Symptoms & Phenotypes for Nut Allergy

Symptoms:

12
  • asthma

MGI Mouse Phenotypes related to Nut Allergy:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.03 CCR6 CD4 ENPP3 FOXP3 IL10 IL13
2 homeostasis/metabolism MP:0005376 10 CCR6 CD4 CD63 FOXP3 IL10 IL13
3 digestive/alimentary MP:0005381 9.97 CD4 CD63 ENPP3 FOXP3 IL10 IL13
4 immune system MP:0005387 9.77 CCR6 CD4 ENPP3 FOXP3 IL10 IL13
5 respiratory system MP:0005388 9.23 ENPP3 FOXP3 IL10 IL13 IL4 IL5

Drugs & Therapeutics for Nut Allergy

Drugs for Nut Allergy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cefpodoxime Approved, Vet_approved 80210-62-4, 82619-04-3 6335986
2
tannic acid Approved 1401-55-4
3
Benzocaine Approved, Investigational 1994-09-7, 94-09-7 2337
4 Anti-Bacterial Agents
5 Cefpodoxime proxetil
6 Anti-Infective Agents
7 Soy Bean

Interventional clinical trials:

(show all 20)
# Name Status NCT ID Phase Drugs
1 Walnut Oral Immunotherapy for Tree Nut Allergy Active, not recruiting NCT01546753 Phase 1, Phase 2 Walnut Protein Powder;Oat Powder (placebo)
2 Walnut Oral Immunotherapy for Tree Nut Allergy Withdrawn NCT01834352 Phase 1, Phase 2 Walnut Protein Flour;Oat flour
3 Trichuris Suis Ova Therapy for Mild to Moderate Peanut and Tree Nut Allergy in Adults and Children Completed NCT01070498 Phase 1 Trichuris suis ova (TSO)
4 Nut Allergy Study: Improving Diagnosis And Treatment Of Nut Allergy Completed NCT01502878
5 The Effect of Per Oral Immunotherapy in Severe IgE Mediated Egg, Milk and Nut Allergy in Adults Completed NCT01822353
6 Tree Nuts Allergies: Does a Single Nut Allergy Necessitate the Dietary Eviction? Completed NCT01744990
7 Potential Allergens in Wine: Double Blind Placebo-controlled Trial and Basophil Activation Analysis Completed NCT00163735 Administration of wine fined with potential food allergens
8 Visual Recognition of Allergens by Allergic Patients and/or Their Parents Completed NCT02966938
9 Phenotypical Characterization of Peanut Allergic Children With Differences in Cross-allergy to Tree Nuts and Other Legumes Completed NCT02961452
10 Mucosal Immunity of Ulcerative Colitis Patients Undergoing Therapy With Trichuris Suis Ova Completed NCT01433471 Trichuris suis ova
11 Trial To Reduce Food Allergy Anxiety by Holding the Allergen (TOUCH Study) Completed NCT03349047
12 Clinical and Biological Efficacy of Peanut Oral Immunotherapy Completed NCT02979600
13 Basophil Activation Test to Diagnose Food Allergy Recruiting NCT03309488
14 Comparison of Protocols for Re-introducing Tree Nuts in Patients With Allergy to Tree Nuts Recruiting NCT04151069
15 Peanut/Tree Nut Desensitization and Induction of Tolerance in Children Recruiting NCT03532360
16 Assessing Tolerance to "May Contain Traces" Processed Foods in Tree Nuts or Peanut Allergic Children. Recruiting NCT03680066
17 Nut Cross-Reactivity - ACuiring Knowledge for Elimination Recommendations (NUT-CRACKER) Study Recruiting NCT02786914
18 Blood Samples for the Study of Peanut, Tree Nut and Other Food Allergies Recruiting NCT02192866
19 Mixed Tree Nut Food Challenges Enrolling by invitation NCT02070263
20 Walnut Oral Immunotherapy for Tree Nut Allergy-CHOP Withdrawn NCT01918657 walnut powder;walnut powder

Search NIH Clinical Center for Nut Allergy

Cochrane evidence based reviews: nut hypersensitivity

Genetic Tests for Nut Allergy

Anatomical Context for Nut Allergy

MalaCards organs/tissues related to Nut Allergy:

40
Skin, Eye, B Cells, Testes, T Cells, Thymus, Thyroid

Publications for Nut Allergy

Articles related to Nut Allergy:

(show top 50) (show all 191)
# Title Authors PMID Year
1
Identification of common allergenic structures in hazel pollen and hazelnuts: a possible explanation for sensitivity to hazelnuts in patients allergic to tree pollen. 54 61
1281178 1992
2
Skin Prick Test Predictive Values for the Outcome of Cashew Challenges in Children. 61
31276826 2020
3
Real-world tree nut consumption in peanut-allergic individuals. 61
31805359 2019
4
Cashew Nut Allergy: Clinical Relevance and Allergen Characterisation. 61
27585580 2019
5
Pistachio and cashew nut allergy in childhood: Predictive factors towards development of a decision tree. 61
31310145 2019
6
Incidence, clinical features, and outcomes of food allergy in children who underwent liver transplant: 16-year experience. 61
30884056 2019
7
Walnut oral immunotherapy for desensitisation of walnut and additional tree nut allergies (Nut CRACKER): a single-centre, prospective cohort study. 61
30926371 2019
8
Effects of thermal treatment on walnut detection and allergenicity. 61
30324619 2019
9
Patterns of tree nut sensitization and allergy in the first 6 years of life in a population-based cohort. 61
30171872 2019
10
Clinical presentation of cashew nut allergy in a paediatric cohort attending an allergy clinic in the West of Ireland. 61
29623581 2019
11
An Approach to the Diagnostic Challenges of Tree Nut Allergy. 61
30973100 2019
12
Pistachio nut allergy: An updated overview. 61
28925724 2019
13
IgE Cross-Reactivity of Cashew Nut Allergens. 61
30368491 2019
14
Tree nut allergy and anxiety related factors modulate food consumption behaviour in peanut-allergic patients: Results of the MIRABEL survey. 61
30253193 2018
15
Almond Allergy: An Overview on Prevalence, Thresholds, Regulations and Allergen Detection. 61
30412996 2018
16
Asian children living in Australia have a different profile of allergy and anaphylaxis than Australian-born children: A State-wide survey. 61
30025179 2018
17
Tree nut allergens. 61
29680588 2018
18
Tree nut allergies: Allergen homology, cross-reactivity, and implications for therapy. 61
29700869 2018
19
Cashew nut allergy in Singaporean children. 61
30079307 2018
20
Threshold dose distribution for cashew nut allergy in children. 61
29671917 2018
21
Component-resolved diagnostics demonstrates that most peanut-allergic individuals could potentially introduce tree nuts to their diet. 61
29377469 2018
22
How to diagnose food allergy. 61
29601353 2018
23
Poly(anhydride) nanoparticles containing cashew nut proteins can induce a strong Th1 and Treg immune response after oral administration. 61
29428795 2018
24
Pine nut allergy in Korean children: Clinical characteristics and diagnostic values of specific IgE against pine nuts. 61
29395441 2018
25
Short-term ibrutinib therapy suppresses skin test responses and eliminates IgE-mediated basophil activation in adults with peanut or tree nut allergy. 61
29360526 2018
26
Self-reported adverse food reactions and anaphylaxis in the SchoolNuts study: A population-based study of adolescents. 61
29174346 2018
27
NUT Co Reactivity - ACquiring Knowledge for Elimination Recommendations (NUT CRACKER) study. 61
29127694 2018
28
Management of nut allergy in primary care. 61
29371317 2018
29
Current perspectives on tree nut allergy: a review. 61
29618933 2018
30
Preliminary psychometric analyses and clinical performance of a caregiver self-efficacy scale for food allergy self-management. 61
29273132 2018
31
First reported case in Canada of anaphylaxis to lupine in a child with peanut allergy. 61
30386385 2018
32
Recent advances in understanding and preventing peanut and tree nut hypersensitivity. 61
30467518 2018
33
Coconut Allergy Revisited. 61
28961189 2017
34
Nut Allergy in Two Different Areas of Spain: Differences in Clinical and Molecular Pattern. 61
28825657 2017
35
Prediction of cashew nut allergy in sensitized children. 61
28423473 2017
36
B-FAHF-2 plus oral immunotherapy (OIT) is safer and more effective than OIT alone in a murine model of concurrent peanut/tree nut allergy. 61
28397379 2017
37
Nut allergy guidelines discourage complete avoidance. 61
28584009 2017
38
Nut allergy guideline. 61
28574656 2017
39
BSACI guideline for the diagnosis and management of peanut and tree nut allergy. 61
28836701 2017
40
Managing Nut Allergy: A Remaining Clinical Challenge. 61
27793601 2017
41
Comparison of the Performance of Skin Prick, ImmunoCAP, and ISAC Tests in the Diagnosis of Patients with Allergy. 61
28456812 2017
42
sIgE Ana o 1, 2 and 3 accurately distinguish tolerant from allergic children sensitized to cashew nuts. 61
27513566 2017
43
Identification, characterization, and initial epitope mapping of pine nut allergen Pin k 2. 61
29195881 2016
44
Development of sesame tolerance and cosensitization of sesame allergy with peanut and tree nut allergy in children. 61
28073703 2016
45
Threshold dose distribution and eliciting dose of cashew nut allergy. 61
27773603 2016
46
Hazelnut Allergens: Molecular Characterization, Detection, and Clinical Relevance. 61
25751378 2016
47
Asymptomatic LTP sensitisation is common in plant-food allergic children from the Northeast of Spain. 61
27040809 2016
48
Does providing written dietary advice improve the ingestion of non-allergic nuts in children with existing nut allergies? - A randomized controlled trial. 61
26892074 2016
49
Cross-sensitization profiles of edible nuts in a birch-endemic area. 61
26706253 2016
50
Nut allergy prevalence and differences between Asian-born children and Australian-born children of Asian descent: a state-wide survey of children at primary school entry in Victoria, Australia. 61
26728850 2016

Variations for Nut Allergy

Expression for Nut Allergy

Search GEO for disease gene expression data for Nut Allergy.

Pathways for Nut Allergy

Pathways related to Nut Allergy according to GeneCards Suite gene sharing:

(show all 21)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.28 STAT6 IL5 IL4 IL13 IL10 CD4
2
Show member pathways
13.23 STAT6 IL5 IL4 IL13 IL10 IGHE
3
Show member pathways
12.76 IL5 IL4 IL13 IL10 ICOSLG FOXP3
4
Show member pathways
12.49 IL4 IL10 IGHE ICOSLG CD4
5 12.49 STAT6 IL4 IL10 FOXP3 ENPP3 CD63
6
Show member pathways
12.49 STAT6 IL5 IL4 IL13 IL10 FOXP3
7
Show member pathways
12.16 TSLP STAT6 IL5 IL4 IL13 IL10
8 11.91 STAT6 IL4 IL13 IL10 IGHE
9 11.88 IL5 IL4 IL10 CD4
10 11.77 IL5 IL4 CD4
11 11.67 IL5 IL4 IL13
12
Show member pathways
11.62 IL5 IL4 FOXP3
13 11.59 IL4 IL13 IL10
14 11.52 IL5 IL4 IL13
15 11.45 STAT6 IL5 IL4 IL10 IGHE
16 11.4 TSLP IL5 IL4 IL13 IL10 CD4
17 11.39 IL4 IL13 IL10
18 11.24 TSLP IL5 IL4 IL13
19 11.08 IL5 IL4 IL13 IL10
20 11.02 IL5 IL4 IL13 IL10 CD4
21 10.83 STAT6 IL5 IL4 IL13 IL10 FOXP3

GO Terms for Nut Allergy

Cellular components related to Nut Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 TSLP TNXB IL5 IL4 IL13 IL10
2 external side of plasma membrane GO:0009897 9.1 IL13 IGHE ICOSLG ENPP3 CD4 CCR6

Biological processes related to Nut Allergy according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.13 TSLP STAT6 PDCL IL5 IL4 IL10
2 positive regulation of cold-induced thermogenesis GO:0120162 9.72 STAT6 IL4 IL13
3 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.69 TSLP IL4 IL13
4 positive regulation of B cell proliferation GO:0030890 9.58 IL5 IL4 IL13
5 immune response GO:0006955 9.56 IL5 IL4 IL13 IL10 IGHE ENPP3
6 positive regulation of MHC class II biosynthetic process GO:0045348 9.54 IL4 IL10
7 negative regulation of endothelial cell apoptotic process GO:2000352 9.54 IL4 IL13 IL10
8 negative regulation of tumor necrosis factor biosynthetic process GO:0042536 9.52 IL4 IL10
9 positive regulation of interleukin-13 production GO:0032736 9.49 TSLP IL4
10 type 2 immune response GO:0042092 9.46 IL4 IL10
11 T cell activation GO:0042110 9.46 IL4 ICOSLG FOXP3 CD4
12 regulation of isotype switching GO:0045191 9.43 IL4 IL10
13 negative regulation of complement-dependent cytotoxicity GO:1903660 9.32 IL4 IL13
14 positive regulation of isotype switching to IgE isotypes GO:0048295 9.26 STAT6 IL4
15 cytokine-mediated signaling pathway GO:0019221 9.17 STAT6 IL5 IL4 IL13 IL10 IGHE

Molecular functions related to Nut Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 TSLP IL5 IL4 IL13 IL10

Sources for Nut Allergy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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