Aliases & Classifications for Nut Allergy

MalaCards integrated aliases for Nut Allergy:

Name: Nut Allergy 12 76 15
Nut Hypersensitivity 44 73
Nut Allergic Reaction 12
Allergy to Nuts 12
Allergy Nut 55

Classifications:



External Ids:

Disease Ontology 12 DOID:4379
MeSH 44 D021184
SNOMED-CT 68 395654004 91934008
UMLS 73 C0577620

Summaries for Nut Allergy

MalaCards based summary : Nut Allergy, also known as nut hypersensitivity, is related to egg allergy and asthma. An important gene associated with Nut Allergy is STAT6 (Signal Transducer And Activator Of Transcription 6), and among its related pathways/superpathways are NF-kappaB Signaling and Th17 cell differentiation. The drugs English walnut and Cefpodoxime have been mentioned in the context of this disorder. Affiliated tissues include testes, skin and b cells, and related phenotype is immune system.

Wikipedia : 76 A tree nut allergy is a hypersensitivity to dietary substances from tree nuts and edible tree seeds... more...

Related Diseases for Nut Allergy

Diseases related to Nut Allergy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 36)
# Related Disease Score Top Affiliating Genes
1 egg allergy 30.3 IL5 IQCE
2 asthma 28.7 FLG IL5 STAT6 TLR9
3 peanut allergy 11.1
4 exercise-induced anaphylaxis 10.6 ENPP3 FLG
5 intestinal schistosomiasis 10.4 IL5 STAT6
6 urinary schistosomiasis 10.4 IL5 STAT6
7 primary amebic meningoencephalitis 10.4 IL5 STAT6
8 latex allergy 10.3 FLG IL5
9 nasal cavity disease 10.3 IL5 TLR9
10 nose disease 10.2 IL5 TLR9
11 common cold 10.2 IL5 TLR9
12 parasitic helminthiasis infectious disease 10.2 IL5 TLR9
13 lichen disease 10.2 FOXP3 TLR9
14 upper respiratory tract disease 10.1 IL5 TLR9
15 leukocyte disease 10.1 IL5 TLR9
16 bronchial disease 10.1 IL5 STAT6 TLR9
17 respiratory system disease 10.0 IL5 STAT6 TLR9
18 esophagitis, eosinophilic, 1 10.0 FLG IL5 STAT6
19 filariasis 10.0 IL5 TLR9
20 ige responsiveness, atopic 10.0 FLG IL5 STAT6
21 eosinophilic gastritis 10.0 FOXP3 IL5
22 pollen allergy 10.0 FOXP3 IL5
23 keratoconjunctivitis 9.9 IL5 TLR9
24 norwegian scabies 9.9 FOXP3 IL5
25 yellow fever 9.9 IL5 SCP2 TLR9
26 allergic contact dermatitis 9.8 FLG IL5
27 cutaneous leishmaniasis 9.7 FOXP3 IL5 TLR9
28 hypersensitivity reaction disease 9.6 FOXP3 IL5 TLR9
29 dermatitis, atopic 9.6 FLG IL5 STAT6 TLR9
30 immune system disease 9.6 FOXP3 IL5 TLR9
31 aspergillosis 9.6 IL5 TLR9
32 apple allergy 9.6 FOXP3 IL5 SCP2
33 autoimmune disease 9.5 FOXP3 IL5 TLR9
34 inflammatory bowel disease 9.2 FOXP3 IL5 STAT6 TLR9
35 allergic hypersensitivity disease 8.8 ENPP3 FLG IL5 SCP2 STAT6 TLR9
36 food allergy 8.8 FLG FOXP3 IL5 SCP2 STAT6

Graphical network of the top 20 diseases related to Nut Allergy:



Diseases related to Nut Allergy

Symptoms & Phenotypes for Nut Allergy

MGI Mouse Phenotypes related to Nut Allergy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.17 IL5 SCP2 STAT6 TLR9 TNS1 ENPP3

Drugs & Therapeutics for Nut Allergy

Drugs for Nut Allergy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 English walnut Approved, Nutraceutical Phase 1, Phase 2,Phase 2,Not Applicable
2
Cefpodoxime Approved, Vet_approved Not Applicable 82619-04-3, 80210-62-4 6335986
3 Cefpodoxime proxetil Not Applicable
4 Soy Bean Nutraceutical Not Applicable

Interventional clinical trials:

(show all 17)
# Name Status NCT ID Phase Drugs
1 Walnut Oral Immunotherapy for Tree Nut Allergy Active, not recruiting NCT01546753 Phase 1, Phase 2 Walnut Protein Powder;Oat Powder (placebo)
2 Walnut Oral Immunotherapy for Tree Nut Allergy Withdrawn NCT01834352 Phase 1, Phase 2 Walnut Protein Flour;Oat flour
3 Trichuris Suis Ova in Peanut and Tree Nut Allergy Completed NCT01070498 Phase 1 Trichuris suis ova (TSO)
4 Tree Nuts Allergies: Does a Single Nut Allergy Necessitate the Dietary Eviction of Other Tree Nuts? Unknown status NCT01744990 Not Applicable
5 Nut Allergy Study: Double-blind Challenge and Oral Desensitization Completed NCT01502878 Not Applicable
6 Visual Recognition of Allergens by Allergic Patients and/or Their Parents Completed NCT02966938
7 Phenotypical Characterization of Peanut Allergic Children Completed NCT02961452
8 Immunologic Profile of Children With Severe Allergies to Peanuts and Nuts After Induction of Tolerance Completed NCT01996774
9 One-year Survey of Anaphylaxis in Outpatient Children Allergic to Peanuts, Walnuts/Hazelnuts, Shellfish Completed NCT02640560
10 Potential Allergens in Wine: Double-blind Placebo-controlled Trial Completed NCT00163735 Not Applicable Administration of wine fined with potential food allergens
11 Peanut and Tree Nut Desensitization Recruiting NCT03532360 Not Applicable
12 Blood Samples for the Study of Peanut, Tree Nut and Other Food Allergies Recruiting NCT02192866
13 Anxiety About Casual Exposure to Food Allergens Recruiting NCT03349047 Not Applicable
14 Basophil Activation Test to Diagnose Food Allergy Recruiting NCT03309488
15 The Effect of Per Oral Immunotherapy in Severe IgE Mediated Egg, Milk, and Nut Allergy in Adults Active, not recruiting NCT01822353 Not Applicable
16 Mixed Tree Nut Food Challenges Enrolling by invitation NCT02070263
17 Walnut Oral Immunotherapy for Tree Nut Allergy Withdrawn NCT01918657 Not Applicable walnut powder;walnut powder

Search NIH Clinical Center for Nut Allergy

Cochrane evidence based reviews: nut hypersensitivity

Genetic Tests for Nut Allergy

Anatomical Context for Nut Allergy

MalaCards organs/tissues related to Nut Allergy:

41
Testes, Skin, B Cells

Publications for Nut Allergy

Articles related to Nut Allergy:

(show all 42)
# Title Authors Year
1
Pine nut allergy in Korean children: Clinical characteristics and diagnostic values of specific IgE against pine nuts. ( 29395441 )
2018
2
Current perspectives on tree nut allergy: a review. ( 29618933 )
2018
3
Management of nut allergy in primary care. ( 29371317 )
2018
4
Short term ibrutinib therapy suppresses skin test responses and eliminates IgE-mediated basophil activation in adults with peanut or tree nut allergy. ( 29360526 )
2018
5
Threshold dose distribution for cashew nut allergy in children. ( 29671917 )
2018
6
Clinical presentation of cashew nut allergy in a paediatric cohort attending an allergy clinic in the West of Ireland. ( 29623581 )
2018
7
Nut Allergy in Two Different Areas of Spain: Differences in Clinical and Molecular Pattern. ( 28825657 )
2017
8
Nut allergy guideline. ( 28574656 )
2017
9
Prediction of cashew nut allergy in sensitized children. ( 28423473 )
2017
10
B-FAHF-2 plus oral immunotherapy (OIT) is safer and more effective than OIT alone in a murine model of concurrent peanut/tree nut allergy. ( 28397379 )
2017
11
BSACI guideline for the diagnosis and management of peanut and tree nut allergy. ( 28836701 )
2017
12
Nut allergy guidelines discourage complete avoidance. ( 28584009 )
2017
13
Pistachio nut allergy: An updated overview. ( 28925724 )
2017
14
Managing Nut Allergy: A Remaining Clinical Challenge. ( 27793601 )
2016
15
Nut allergy prevalence and differences between Asian-born children and Australian-born children of Asian descent: a state-wide survey of children at primary school entry in Victoria, Australia. ( 26728850 )
2016
16
Cashew Nut Allergy: Clinical Relevance and Allergen Characterisation. ( 27585580 )
2016
17
Is Microarray Analysis Really Useful and Sufficient to Diagnose Nut Allergy in the Mediterranean Area? ( 27012014 )
2016
18
Development of sesame tolerance and cosensitization of sesame allergy with peanut and tree nut allergy in children. ( 28073703 )
2016
19
Specific IgE to recombinant protein (Ber e 1) for the diagnosis of Brazil nut allergy. ( 26684696 )
2016
20
Threshold dose distribution and eliciting dose of cashew nut allergy. ( 27773603 )
2016
21
A retrospective study of peanut and tree nut allergy: Sensitization and correlations with clinical manifestations. ( 25860169 )
2015
22
Peanut and tree nut allergy. ( 26022873 )
2015
23
Tree nut allergy: risk factors for development, mitigation of reaction risk and current efforts in desensitization. ( 25824522 )
2015
24
Dietary management of peanut and tree nut allergy: what exactly should patients avoid? ( 25443673 )
2015
25
High consumption of peanuts or tree nuts by non-allergic mothers around the time of pregnancy reduces the risk of nut allergy in the child. ( 24986044 )
2015
26
Cardiac mMCP-4+ mast cell expansion and elevation of IL-6, and CCR1/3 and CXCR2 signaling chemokines in an adjuvant-free mouse model of tree nut allergy. ( 25499102 )
2015
27
Oral immunotherapy initiation for multi-nut allergy: a case report. ( 25838098 )
2015
28
Usefulness of open mixed nut challenges to exclude tree nut allergy in children. ( 26034579 )
2015
29
A retrospective study of peanut and tree nut allergy: Sensitization and correlations with clinical manifestations. ( 25730137 )
2015
30
The Prevalence of Tree Nut Allergy: A Systematic Review. ( 26233427 )
2015
31
Particularities in a Child With Cashew Nut Allergy. ( 27335909 )
2014
32
Prospective study of peripregnancy consumption of peanuts or tree nuts by mothers and the risk of peanut or tree nut allergy in their offspring. ( 24366539 )
2014
33
Systematic review on cashew nut allergy. ( 24734868 )
2014
34
Identification of T- and B-Cell Subsets That Expand in the Central and Peripheral Lymphoid Organs during the Establishment of Nut Allergy in an Adjuvant-Free Mouse Model. ( 23724246 )
2013
35
"Dude! You mean you've never eaten a peanut butter and jelly sandwich?!?" Nut allergy as stigma in comic books. ( 22574889 )
2013
36
Lipids are required for the development of Brazil nut allergy: the role of mouse and human iNKT cells. ( 23137012 )
2013
37
Infant Feeding Practices and Nut Allergy over Time in Australian School Entrant Children. ( 22811733 )
2012
38
Pine nut allergy: clinical features and major allergens characterization. ( 23081934 )
2012
39
Tree nut allergy, egg allergy, and asthma in children. ( 21098525 )
2011
40
Basophil CD203c levels are increased at baseline and can be used to monitor omalizumab treatment in subjects with nut allergy. ( 20975283 )
2011
41
The diagnosis of Brazil nut allergy using history, skin prick tests, serum-specific immunoglobulin E and food challenges. ( 16433861 )
2006
42
Polymorphism in the STAT6 gene encodes risk for nut allergy. ( 12058257 )
2002

Variations for Nut Allergy

Expression for Nut Allergy

Search GEO for disease gene expression data for Nut Allergy.

Pathways for Nut Allergy

Pathways related to Nut Allergy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.77 ENPP3 FOXP3 STAT6 TLR9
2
Show member pathways
11.75 FOXP3 IL5 STAT6
3 10.46 FOXP3 IL5 STAT6

GO Terms for Nut Allergy

Biological processes related to Nut Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of B cell proliferation GO:0030890 8.96 IL5 TLR9
2 negative regulation of interleukin-6 production GO:0032715 8.62 FOXP3 TLR9

Sources for Nut Allergy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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