NMC
MCID: NTM002
MIFTS: 40

Nut Midline Carcinoma (NMC)

Categories: Cancer diseases, Rare diseases

Aliases & Classifications for Nut Midline Carcinoma

MalaCards integrated aliases for Nut Midline Carcinoma:

Name: Nut Midline Carcinoma 12 59 15 73
Nuclear Protein in Testis Midline Carcinoma 12
Nmc 59

Characteristics:

Orphanet epidemiological data:

59
nut midline carcinoma
Inheritance: Not applicable;

Classifications:



External Ids:

Disease Ontology 12 DOID:0060463
NCIt 50 C45716
Orphanet 59 ORPHA443167
ICD10 via Orphanet 34 C80.9
UMLS 73 C1707291

Summaries for Nut Midline Carcinoma

Disease Ontology : 12 A carcinoma that is characterized by a BRD4-NUT translocation involving the rearrangement of the bromodomain-containing protein 4 (BRD4) and the gene encoding nuclear protein of the testis (NUT) at 15q14, BRD4-NUT t(15;19)(q14;q13.1) and arises from midline epithelial structures, most commonly the head, neck, and mediastinum.

MalaCards based summary : Nut Midline Carcinoma, also known as nuclear protein in testis midline carcinoma, is related to lung cancer and neonatal leukemia. An important gene associated with Nut Midline Carcinoma is NUTM1 (NUT Midline Carcinoma Family Member 1), and among its related pathways/superpathways are Chromatin Regulation / Acetylation and Pathways Affected in Adenoid Cystic Carcinoma. The drugs Rucaparib and Paclitaxel have been mentioned in the context of this disorder. Affiliated tissues include testis, lung and tonsil, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : 76 NUT carcinoma (formerly NUT midline carcinoma), is a rare genetically defined, very aggressive squamous... more...

Related Diseases for Nut Midline Carcinoma

Diseases related to Nut Midline Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 23)
# Related Disease Score Top Affiliating Genes
1 lung cancer 10.2
2 neonatal leukemia 10.1 EP300 MYC
3 venous hemangioma 10.1 MYC SOX2
4 learning disability 10.1
5 heparin-induced thrombocytopenia 10.1
6 methylmalonic aciduria, cblb type 10.1 MYC SOX2
7 germ cell and embryonal cancer 10.0 MYC SOX2
8 extragonadal seminoma 10.0 BRD4 NUTM1 SOX2
9 acute leukemia 10.0
10 leukemia 10.0
11 adenoid cystic carcinoma 10.0
12 tonsillitis 10.0
13 sarcoma 10.0
14 thymus cancer 10.0
15 mucoepidermoid carcinoma 10.0
16 herpes zoster 10.0
17 germ cells tumors 10.0
18 medullomyoblastoma 10.0 MYC SMARCB1
19 t-cell prolymphocytic leukemia 9.9 MYC SMARCB1
20 infratentorial cancer 9.9 MYC SMARCB1
21 central nervous system cancer 9.9 MYC SMARCB1 SOX2
22 ewing sarcoma 9.8 BRD4 EP300 MYC SOX2
23 large intestine cancer 9.7 DCC MYC SOX2

Graphical network of the top 20 diseases related to Nut Midline Carcinoma:



Diseases related to Nut Midline Carcinoma

Symptoms & Phenotypes for Nut Midline Carcinoma

GenomeRNAi Phenotypes related to Nut Midline Carcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00221-A-1 10.55 BRDT SMARCB1 BRD4 MYC SOX2
2 Decreased viability GR00221-A-2 10.55 BRDT DCC EP300 SMARCB1
3 Decreased viability GR00221-A-3 10.55 BRDT DCC SMARCB1 BRD4 MYC
4 Decreased viability GR00221-A-4 10.55 BRDT DCC BRD4 SOX2 BRD3
5 Decreased viability GR00342-S-3 10.55 BRDT
6 Decreased viability GR00381-A-1 10.55 SMARCB1
7 Decreased viability GR00402-S-2 10.55 BRDT DCC EP300 SMARCB1 BRD4 MYC
8 Reduced mammosphere formation GR00396-S 9.1 BRD4 DCC EP300 MYC SMARCB1 SOX2

MGI Mouse Phenotypes related to Nut Midline Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.02 DCC EP300 MYC SMARCB1 SOX2

Drugs & Therapeutics for Nut Midline Carcinoma

Drugs for Nut Midline Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Rucaparib Approved, Investigational Phase 1, Phase 2 283173-50-2 9931954
2
Paclitaxel Approved, Vet_approved Phase 1, Phase 2 33069-62-4 36314
3
Azacitidine Approved, Investigational Phase 1, Phase 2 320-67-2 9444
4
Gemcitabine Approved Phase 1, Phase 2 95058-81-4 60750
5 Albumin-Bound Paclitaxel Phase 1, Phase 2
6 Antiviral Agents Phase 1, Phase 2
7 Immunosuppressive Agents Phase 1, Phase 2
8 Poly(ADP-ribose) Polymerase Inhibitors Phase 1, Phase 2
9 Immunologic Factors Phase 1, Phase 2
10 Anti-Infective Agents Phase 1, Phase 2
11 Antimetabolites Phase 1, Phase 2
12 Antimetabolites, Antineoplastic Phase 1, Phase 2
13 Pharmaceutical Solutions Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 An Open-Label, Dose-Escalation Study of INCB054329 in Patients With Advanced Malignancies Completed NCT02431260 Phase 1, Phase 2 INCB054329 Monotherapy
2 Open-Label Safety and Tolerability Study of INCB057643 in Subjects With Advanced Malignancies Active, not recruiting NCT02711137 Phase 1, Phase 2 INCB057643;INCB057643;Gemcitabine;Paclitaxel;Rucaparib;Abiraterone;Ruxolitinib;Azacitidine
3 A Dose-Finding Study of MK-8628, a Small Molecule Inhibitor of the Bromodomain and Extra-Terminal (BET) Proteins, in Adults With Selected Advanced Solid Tumors (MK-8628-003) Completed NCT02259114 Phase 1 MK-8628
4 A Study to Investigate the Safety, Pharmacokinetics, Pharmacodynamics, and Clinical Activity of GSK525762 in Subjects With NUT Midline Carcinoma (NMC) and Other Cancers Active, not recruiting NCT01587703 Phase 1 GSK525762
5 Open Label, Multi-center Study to Assess the Safety, Tolerability and Pharmacokinetics of CUDC-907 in Subjects With Advanced/Relapsed Solid Tumors Active, not recruiting NCT02307240 Phase 1 CUDC-907
6 A Dose Exploration Study With MK-8628 in Participants With Selected Advanced Solid Tumors (MK-8628-006) Terminated NCT02698176 Phase 1 MK-8628
7 BAY1238097, First in Man Terminated NCT02369029 Phase 1 BAY 1238097
8 Compassionate Use Individual Request Program for GSK525762 in NUT Midline Carcinoma Available NCT03702036 molibresib

Search NIH Clinical Center for Nut Midline Carcinoma

Genetic Tests for Nut Midline Carcinoma

Anatomical Context for Nut Midline Carcinoma

MalaCards organs/tissues related to Nut Midline Carcinoma:

41
Testis, Lung, Tonsil, T Cells, Thymus

Publications for Nut Midline Carcinoma

Articles related to Nut Midline Carcinoma:

(show top 50) (show all 86)
# Title Authors Year
1
Rediagnosis of Lung Cancer as NUT Midline Carcinoma Based on Clues From Tumor Genomic Profiling. ( 29752320 )
2018
2
Nut Midline Carcinoma in the Mediastinum in a Ten-Year-Old Boy. ( 29650254 )
2018
3
Patterns of care and impact of prognostic factors in the outcome of NUT midline carcinoma: a systematic review and individual patient data analysis of 119 cases. ( 29356890 )
2018
4
NUT midline carcinoma with leukemic presentation mimicking CD34-positive acute leukemia. ( 30049733 )
2018
5
NUT midline carcinoma causing critical stenosis of the coronary arteries: CT demonstration. ( 28797547 )
2018
6
Genetic modifiers of the BRD4-NUT dependency of NUT midline carcinoma uncovers a synergism between BETis and CDK4/6is. ( 30135075 )
2018
7
Alpha-fetoprotein elevation in NUT midline carcinoma: a case report. ( 28407756 )
2017
8
Uncommon somatic mutations in metastatic NUT midline carcinoma. ( 28967088 )
2017
9
Ectopic protein interactions within BRD4-chromatin complexes drive oncogenic megadomain formation in NUT midline carcinoma. ( 28484033 )
2017
10
Uncovering BRD4 hyperphosphorylation associated with cellular transformation in NUT midline carcinoma. ( 28630312 )
2017
11
NUT Midline Carcinoma: A Rare Malignancy. ( 28441376 )
2017
12
Cytopathologic and immunophenotypic changes in NUT midline carcinoma after targeted therapy. ( 27863099 )
2017
13
Systematic Kinase Inhibitor Profiling Identifies CDK9 as a Synthetic Lethal Target in NUT Midline Carcinoma. ( 28930680 )
2017
14
Complex chromosomal rearrangements by single catastrophic pathogenesis in NUT midline carcinoma. ( 28203693 )
2017
15
Deciphering the Role of microRNAs in BRD4-NUT Fusion Gene Induced NUT Midline Carcinoma. ( 28729764 )
2017
16
NUT Midline Carcinoma: A Series of Five Cases, Including One with Unusual Clinical Course. ( 28948459 )
2017
17
Pediatric NUT-midline carcinoma: Therapeutic success employing a sarcoma based multimodal approach. ( 29040054 )
2017
18
NUT Midline Carcinoma of the Sublingual Gland: Clinical Presentation and Review. ( 28349372 )
2017
19
NUT midline carcinoma as a primary lung tumor: a case report. ( 29312763 )
2017
20
NUT Midline Carcinoma of the Lung in a Six-Year-Old Child. ( 29220605 )
2017
21
Molecular-genetic profiling and high-throughput<i>in vitro</i>drug screening in NUT midline carcinoma-an aggressive and fatal disease. ( 29348827 )
2017
22
A 48-Year-Old Male with Cutaneous Metastases of NUT Midline Carcinoma Misdiagnosed as Herpes Zoster. ( 29279703 )
2017
23
NUT midline carcinoma of the lung, a rare form of lung cancer. ( 27263824 )
2016
24
Intensive treatment and survival outcomes in NUT midline carcinoma of the head and neck. ( 27509377 )
2016
25
Cytological features of NUT midline carcinoma arising in sino-nasal tract and parotid gland: Report of two new cases and review of the literature. ( 27338676 )
2016
26
NUT midline carcinoma of the larynx: An international series and review of the literature. ( 27926786 )
2016
27
The Gross Appearance of a NUT Midline Carcinoma. ( 26378054 )
2016
28
NUT midline carcinoma mimicking a germ cell tumor: a case report. ( 27855672 )
2016
29
Nuclear protein in testis (NUT) midline carcinoma with a novel three-way translocation (4;15;19)(q13;q14;p13.1). ( 27590195 )
2016
30
NUT Midline Carcinoma of the Nasal Cavity. ( 27757815 )
2016
31
Intrapericardial NUT Midline Carcinoma: Unusual Presentation of a Rare Tumor and Literature Review with Management Considerations. ( 26667959 )
2016
32
Cytopathologic features of NUT midline carcinoma: A series of 26 specimens from 13 patients. ( 27400194 )
2016
33
Orbital Involvement by NUT Midline Carcinoma. ( 24892275 )
2015
34
A case of endobronchial NUT midline carcinoma with intraluminal growth. ( 25750317 )
2015
35
NUT Midline Carcinoma: Morphoproteomic Characterization with Genomic and Therapeutic Correlates. ( 26663801 )
2015
36
A novel BRD4-NUT fusion in an undifferentiated sinonasal tumor highlights alternative splicing as a contributing oncogenic factor in NUT midline carcinoma. ( 26551281 )
2015
37
NUT Midline Carcinoma in Elderly Patients: Usefulness of 18F-FDG PET/CT for Treatment Assessment. ( 25899594 )
2015
38
Staging and evaluation of neoadjuvant chemotherapy response with A^a8,F-FDG PET/CT in NUT-midline carcinoma in a child: a case report and review of the literature. ( 25304847 )
2015
39
Primary Pulmonary NUT Midline Carcinoma: Clinical, Radiographic, and Pathologic Characterizations. ( 26001144 )
2015
40
NUT midline carcinoma presenting with bilateral ovarian metastases: a case report. ( 25675182 )
2015
41
Histone deacetylase inhibitor for NUT midline carcinoma. ( 25557064 )
2015
42
Retrospective analysis of nuclear protein in testis (NUT) midline carcinoma in the upper aerodigestive tract and mediastinum. ( 25434692 )
2015
43
Cytological Features of a Variant NUT Midline Carcinoma of the Lung Harboring the NSD3-NUT Fusion Gene: A Case Report and Literature Review. ( 25685583 )
2015
44
Cytologic findings of NUT midline carcinoma in the hilum of the lung. ( 26138851 )
2015
45
Sinonasal NUT-Midline Carcinoma - A Multimodality Approach to Diagnosis, Staging and Post-Surgical Restaging. ( 26244120 )
2015
46
NUT midline carcinoma of the mediastinum showing two types of poorly differentiated tumor cells: a case report and a literature review. ( 25433996 )
2015
47
Impressive Response to Dose-Dense Chemotherapy in a Patient with NUT Midline Carcinoma. ( 26140332 )
2015
48
A rare Japanese case with a NUT midline carcinoma in the nasal cavity: a case report with immunohistochemical and genetic analyses. ( 24655834 )
2014
49
NUT Midline Carcinoma Masquerading As a Thymic Carcinoma. ( 24733790 )
2014
50
Usefulness of Nuclear Protein in Testis (NUT) Immunohistochemistry in the Cytodiagnosis of NUT Midline Carcinoma: A Brief Case Report. ( 25214871 )
2014

Variations for Nut Midline Carcinoma

Copy number variations for Nut Midline Carcinoma from CNVD:

7
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 125781 19 15209300 15304342 Translate BRD4 NUT midline carcinoma

Expression for Nut Midline Carcinoma

Search GEO for disease gene expression data for Nut Midline Carcinoma.

Pathways for Nut Midline Carcinoma

Pathways related to Nut Midline Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.43 BRD4 BRDT EP300 NUTM1 SMARCB1
2 10.95 EP300 KMT2C MYC
3 10.94 EP300 MYC
4 10.72 EP300 MYC

GO Terms for Nut Midline Carcinoma

Cellular components related to Nut Midline Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.36 BRD3 BRD4 BRDT EP300 KLLN KMT2C

Biological processes related to Nut Midline Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.73 BRD4 EP300 MYC SOX2
2 cell cycle arrest GO:0007050 9.54 KLLN MYC SOX2
3 cellular response to UV GO:0034644 9.46 EP300 MYC
4 positive regulation of transcription by RNA polymerase II GO:0045944 9.43 BRD4 EP300 KMT2C MYC SMARCB1 SOX2
5 beta-catenin-TCF complex assembly GO:1904837 9.4 EP300 MYC
6 chromatin remodeling GO:0006338 9.33 BRDT MYC SMARCB1
7 positive regulation by host of viral transcription GO:0043923 9.32 EP300 SMARCB1
8 response to growth factor GO:0070848 9.26 MYC SOX2
9 chromatin organization GO:0006325 9.1 BRD3 BRD4 BRDT KMT2C SMARCB1 SOX2

Molecular functions related to Nut Midline Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA binding GO:0003677 9.8 EP300 KLLN KMT2C MYC SMARCB1 SOX2
2 transcription coactivator activity GO:0003713 9.46 BRDT EP300 KMT2C SMARCB1
3 activating transcription factor binding GO:0033613 9.32 EP300 MYC
4 p53 binding GO:0002039 9.13 BRD4 EP300 SMARCB1
5 lysine-acetylated histone binding GO:0070577 8.8 BRD3 BRD4 BRDT

Sources for Nut Midline Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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