MCID: NTR005
MIFTS: 43

Nutritional Deficiency Disease

Categories: Immune diseases, Blood diseases, Metabolic diseases

Aliases & Classifications for Nutritional Deficiency Disease

MalaCards integrated aliases for Nutritional Deficiency Disease:

Name: Nutritional Deficiency Disease 12 15
Nutrition 43 3
Carbamoyl-Phosphate Synthase I Deficiency Disease 73
Nutritional Deficiency 55
Nutritional Disorder 55
Deficiency Diseases 73
Nutrition Disorders 73
Malnutrition 73

Classifications:



External Ids:

Disease Ontology 12 DOID:5113
MeSH 44 D003677

Summaries for Nutritional Deficiency Disease

MedlinePlus : 43 Food provides the energy and nutrients you need to be healthy. Nutrients include proteins, carbohydrates, fats, vitamins, minerals, and water. Healthy eating is not hard. The key is to Eat a variety of foods, including vegetables, fruits, and whole-grain products Eat lean meats, poultry, fish, beans, and low-fat dairy products Drink lots of water Limit salt, sugar, alcohol, saturated fat, and trans fat in your diet Saturated fats are usually fats that come from animals. Look for trans fat on the labels of processed foods, margarines, and shortenings. Centers for Disease Control and Prevention

MalaCards based summary : Nutritional Deficiency Disease, also known as nutrition, is related to marasmus and kwashiorkor, and has symptoms including abdominal pain, cachexia and constipation. An important gene associated with Nutritional Deficiency Disease is TF (Transferrin), and among its related pathways/superpathways are Folate Metabolism and HIF-1 signaling pathway. Affiliated tissues include skin, and related phenotypes are homeostasis/metabolism and cardiovascular system

Related Diseases for Nutritional Deficiency Disease

Diseases related to Nutritional Deficiency Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 136)
# Related Disease Score Top Affiliating Genes
1 marasmus 33.0 ALB IGFBP3 TF TTR
2 kwashiorkor 32.9 ALB F2 TF TTR
3 insulin-like growth factor i 32.0 BGLAP IGFBP3 LEP
4 beta-thalassemia 31.4 EPO HAMP TF TFRC
5 nutritional optic neuropathy 12.1
6 rickets 11.5
7 subacute cerebellar degeneration 11.4
8 cystic fibrosis 11.4
9 congenital short bowel syndrome 11.3
10 glossitis 11.1
11 paramyloidosis 11.0 ALB TTR
12 tropical sprue 10.9 ALB GIF
13 biotin deficiency 10.8
14 esophageal cancer 10.8
15 facial dysmorphism, immunodeficiency, livedo, and short stature 10.8
16 pica disease 10.8
17 alcoholic neuropathy 10.8
18 atrophic rhinitis 10.8
19 peripheral nervous system disease 10.8
20 chronic intestinal pseudoobstruction 10.8
21 marchiafava bignami disease 10.8
22 antipyrine metabolism 10.8 ALB F2
23 epstein-barr virus hepatitis 10.8 F2 TF
24 non-a-e hepatitis 10.8 ALB F2
25 testicular yolk sac tumor 10.8 ALB TF TTR
26 median rhomboid glossitis 10.8 TF TTR
27 ariboflavinosis 10.8 ALB MTHFR TF
28 fournier gangrene 10.7 ALB F2
29 burns 10.7 ALB TTR
30 spinal cord infarction 10.7 F2 MTHFR
31 mesenteric vascular occlusion 10.7 F2 MTHFR
32 livedoid vasculopathy 10.7 F2 MTHFR
33 sudden sensorineural hearing loss 10.7 F2 MTHFR
34 blood protein disease 10.6 F2 MTHFR
35 pure red-cell aplasia 10.5 ALB EPO TF
36 obstructive jaundice 10.5 ALB F2 TTR
37 protein-energy malnutrition 10.5 ALB LEP TF TTR
38 alcoholic liver cirrhosis 10.5 ALB F2 TF
39 hepatic vascular disease 10.5 ALB F2 MTHFR
40 vein disease 10.5 ALB F2 MTHFR
41 porphyria cutanea tarda 10.5 HAMP TF TFRC
42 wilson disease 10.5 ALB F2 TF
43 hemochromatosis, type 2a 10.5 HAMP HJV
44 hypogonadism, male 10.5 BGLAP LEP
45 hemoglobinopathy 10.5 EPO HAMP TF
46 hepatic tuberculosis 10.4 ALB F2
47 hemorrhagic fever 10.4 ALB F2 TFRC
48 hemochromatosis type 2 10.4 HAMP HJV
49 eclampsia 10.4 ALB F2 MTHFR
50 fetal erythroblastosis 10.4 ALB EPO TFRC

Comorbidity relations with Nutritional Deficiency Disease via Phenotypic Disease Network (PDN): (show all 12)


Active Peptic Ulcer Disease Acute Cystitis
Alzheimer Disease Decubitus Ulcer
Deficiency Anemia Familial Atrial Fibrillation
Heart Disease Iron Deficiency Anemia
Osteoporosis Protein-Energy Malnutrition
Schizophreniform Disorder Swallowing Disorders

Graphical network of the top 20 diseases related to Nutritional Deficiency Disease:



Diseases related to Nutritional Deficiency Disease

Symptoms & Phenotypes for Nutritional Deficiency Disease

UMLS symptoms related to Nutritional Deficiency Disease:


abdominal pain, cachexia, constipation, diarrhea, nausea and vomiting, decrease in appetite, abdominal symptom

MGI Mouse Phenotypes related to Nutritional Deficiency Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.06 IGFBP3 LEP MGP MTHFR ALB TF
2 cardiovascular system MP:0005385 9.91 HJV IGFBP3 LEP MGP CRP TFRC
3 integument MP:0010771 9.56 HJV IGFBP3 LEP MTHFR TFRC EPO
4 liver/biliary system MP:0005370 9.23 HJV IGFBP3 LEP ALB TFRC EPO

Drugs & Therapeutics for Nutritional Deficiency Disease

Genetic Tests for Nutritional Deficiency Disease

Anatomical Context for Nutritional Deficiency Disease

MalaCards organs/tissues related to Nutritional Deficiency Disease:

41
Skin

Publications for Nutritional Deficiency Disease

Articles related to Nutritional Deficiency Disease:

# Title Authors Year
1
Skin manifestations of nutritional deficiency disease in children: modern day contexts. ( 23171006 )
2012
2
Principles underlying the early diagnosis of nutritional deficiency disease. ( 21016693 )
1946

Variations for Nutritional Deficiency Disease

Expression for Nutritional Deficiency Disease

Search GEO for disease gene expression data for Nutritional Deficiency Disease.

Pathways for Nutritional Deficiency Disease

Pathways related to Nutritional Deficiency Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.1 ALB CRP F2 GIF MTHFR
2 11.58 EPO TF TFRC
3 11.37 EPO LEP TF TFRC
4 10.9 ALB F2 TFRC TTR
5 10.67 BGLAP F2 MGP
6 10.41 HAMP TF TFRC
7 9.64 HAMP HJV TMPRSS6

GO Terms for Nutritional Deficiency Disease

Cellular components related to Nutritional Deficiency Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.83 ALB BGLAP CRP EPO F2 GHRL
2 endoplasmic reticulum lumen GO:0005788 9.73 ALB BGLAP F2 GHRL IGFBP3 TF
3 blood microparticle GO:0072562 9.62 ALB F2 TF TFRC
4 extracellular space GO:0005615 9.53 ALB BGLAP CRP EPO F2 GHRL
5 HFE-transferrin receptor complex GO:1990712 9.33 HJV TF TFRC

Biological processes related to Nutritional Deficiency Disease according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.7 EPO F2 GHRL HAMP LEP TG
2 response to ethanol GO:0045471 9.67 BGLAP HAMP LEP
3 cellular protein metabolic process GO:0044267 9.65 ALB F2 IGFBP3 TF TTR
4 response to estrogen GO:0043627 9.58 BGLAP EPO GHRL
5 response to nutrient levels GO:0031667 9.54 BGLAP GHRL LEP
6 iron ion homeostasis GO:0055072 9.5 HJV TF TMPRSS6
7 peptidyl-glutamic acid carboxylation GO:0017187 9.48 BGLAP F2
8 adult feeding behavior GO:0008343 9.46 GHRL LEP
9 negative regulation of lipid storage GO:0010888 9.43 CRP LEP
10 acute-phase response GO:0006953 9.26 CRP EPO F2 HAMP
11 cellular iron ion homeostasis GO:0006879 9.02 HAMP HJV TF TFRC TMPRSS6

Molecular functions related to Nutritional Deficiency Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transferrin receptor binding GO:1990459 9.16 HJV TF
2 hormone activity GO:0005179 9.1 EPO GHRL HAMP LEP TG TTR
3 structural constituent of bone GO:0008147 8.96 BGLAP MGP

Sources for Nutritional Deficiency Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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