MCID: OBS037
MIFTS: 47

Obesity-Hypoventilation Syndrome

Categories: Blood diseases, Cardiovascular diseases, Metabolic diseases, Respiratory diseases
Data Licensing
For inquiries, contact:

Aliases & Classifications for Obesity-Hypoventilation Syndrome

MalaCards integrated aliases for Obesity-Hypoventilation Syndrome:

Name: Obesity-Hypoventilation Syndrome 57 53
Obesity Hypoventilation Syndrome 63 16 71 75 33
Pickwickian Syndrome 57 33
Extreme Obesity with Alveolar Hypoventilation with Body-Mass-Index Unspecified 33
Ohs - [obesity Hypoventilation Syndrome] 33
Alveolar Hypoventilation Syndrome 33
Alveolus Hypoventilation Syndrome 33
Cardiopulmonary Obesity Syndrome 33

Characteristics:


Inheritance:

Autosomal recessive 57

Classifications:



External Ids:

OMIM® 57 257500
MedGen 40 C0031880
ICD11 33 1514276050
UMLS 71 C0031880

Summaries for Obesity-Hypoventilation Syndrome

PubMed Health : 63 Obesity hypoventilation syndrome: Obesity hypoventilation (HI-po-ven-tih-LA-shun) syndrome (OHS) is a breathing disorder that affects some obese people. In OHS, poor breathing results in too much carbon dioxide (hypoventilation) and too little oxygen in the blood (hypoxemia). OHS sometimes is called Pickwickian syndrome.

MalaCards based summary: Obesity-Hypoventilation Syndrome, also known as obesity hypoventilation syndrome, is related to apnea, obstructive sleep and sleep disorder, and has symptoms including obesity, metabolically benign An important gene associated with Obesity-Hypoventilation Syndrome is ADIPOQ (Adiponectin, C1Q And Collagen Domain Containing), and among its related pathways/superpathways are IL-9 Signaling Pathways and Spinal cord injury. The drugs Acetazolamide and Carbonic Anhydrase Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and medulla oblongata, and related phenotypes are obesity and hypoventilation

Wikipedia: 75 Obesity hypoventilation syndrome (OHS) is a condition in which severely overweight people fail to... more...

More information from OMIM: 257500

Related Diseases for Obesity-Hypoventilation Syndrome

Diseases related to Obesity-Hypoventilation Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 249)
# Related Disease Score Top Affiliating Genes
1 apnea, obstructive sleep 30.5 RETN LEP IL6 ADIPOQ
2 sleep disorder 30.4 LEP IL6 ADIPOQ
3 sleep apnea 30.4 RETN LEP IL6 ADIPOQ
4 leptin deficiency or dysfunction 30.1 RETN LEP IL6 ADIPOQ
5 acanthosis nigricans 30.0 LEP ADIPOQ
6 body mass index quantitative trait locus 11 30.0 RETN LEP IL6 CCL5 ADIPOQ
7 retinal vein occlusion 29.9 IL6 CCL5
8 hypothyroidism 29.8 RETN LEP ADIPOQ
9 bronchitis 29.7 IL6 CCL5
10 non-alcoholic steatohepatitis 29.6 LEP IL6 ADIPOQ
11 chronic kidney disease 29.6 LEP IL6 ADIPOQ
12 peripheral nervous system disease 29.4 LEP IL6 CCL5
13 prader-willi syndrome 29.3 RETN LEP IL6 ADIPOQ
14 uremia 29.3 RETN LEP IL6
15 nutritional deficiency disease 29.0 RETN LEP IL6 ADIPOQ
16 non-alcoholic fatty liver disease 29.0 RETN LEP IL6 ADIPOQ
17 cardiovascular system disease 29.0 RETN LEP IL6 ADIPOQ
18 hypertension, essential 28.8 RETN LEP IL6 CCL5 ADIPOQ
19 idiopathic alveolar hypoventilation syndrome 11.3
20 body mass index quantitative trait locus 9 10.9
21 body mass index quantitative trait locus 8 10.9
22 body mass index quantitative trait locus 4 10.9
23 body mass index quantitative trait locus 10 10.9
24 body mass index quantitative trait locus 7 10.9
25 body mass index quantitative trait locus 12 10.9
26 body mass index quantitative trait locus 14 10.9
27 body mass index quantitative trait locus 18 10.9
28 body mass index quantitative trait locus 19 10.9
29 body mass index quantitative trait locus 20 10.9
30 respiratory failure 10.8
31 pulmonary hypertension 10.7
32 pulmonary disease, chronic obstructive 10.4
33 leptin receptor deficiency 10.4
34 body mass index quantitative trait locus 1 10.3
35 congestive heart failure 10.3
36 polycythemia 10.3
37 neuromuscular disease 10.3
38 lung disease 10.3
39 hyperuricemia, pulmonary hypertension, renal failure, and alkalosis syndrome 10.2
40 papilledema 10.2
41 hirschsprung disease 1 10.1
42 autonomic nervous system disease 10.1
43 myopathy 10.1
44 congenital central hypoventilation syndrome 10.1
45 patent foramen ovale 10.1
46 acquired polycythemia 10.1
47 pulmonary embolism 10.1
48 complete generalized lipodystrophy 10.1 LEP ADIPOQ
49 lipodystrophy, congenital generalized, type 2 10.1 LEP ADIPOQ
50 narcolepsy 10.1

Graphical network of the top 20 diseases related to Obesity-Hypoventilation Syndrome:



Diseases related to Obesity-Hypoventilation Syndrome

Symptoms & Phenotypes for Obesity-Hypoventilation Syndrome

Human phenotypes related to Obesity-Hypoventilation Syndrome:

30
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 obesity 30 HP:0001513
2 hypoventilation 30 HP:0002791
3 cyanosis 30 HP:0000961
4 excessive daytime somnolence 30 HP:0001262

Symptoms via clinical synopsis from OMIM®:

57 (Updated 08-Dec-2022)
Growth:
obesity

Neuro:
somnolence
muscular twitching

Skin:
cyanosis

Resp:
periodic breathing

Clinical features from OMIM®:

257500 (Updated 08-Dec-2022)

UMLS symptoms related to Obesity-Hypoventilation Syndrome:


obesity, metabolically benign

MGI Mouse Phenotypes related to Obesity-Hypoventilation Syndrome:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 muscle MP:0005369 9.56 ADIPOQ IL6 LEP RETN
2 liver/biliary system MP:0005370 9.46 ADIPOQ IL6 LEP RETN
3 adipose tissue MP:0005375 9.26 ADIPOQ IL6 LEP RETN
4 immune system MP:0005387 9.02 ADIPOQ CCL5 IL6 LEP RETN

Drugs & Therapeutics for Obesity-Hypoventilation Syndrome

PubMed Health treatment related to Obesity-Hypoventilation Syndrome: 63

Treatments for obesity hypoventilation syndrome (OHS) include breathing support, weight loss, and medicines. The goals of treating OHS may include: Supporting and aiding your breathing Achieving major weight loss Treating underlying and related conditions

Drugs for Obesity-Hypoventilation Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetazolamide Approved, Vet_approved Phase 3 59-66-5, 1424-27-7 1986
2 Carbonic Anhydrase Inhibitors Phase 3
3 Anticonvulsants Phase 3
4 diuretics Phase 3
5
Ethanol Approved 64-17-5 702
6
Benzocaine Approved, Investigational 1994-09-7, 94-09-7 2337
7
Tannic acid Approved 1401-55-4 16129878 16129778
8
Chlorhexidine Approved, Vet_approved, Withdrawn 55-56-1 2713 9552079
9 Anesthetics
10 Central Nervous System Stimulants
11 Hypnotics and Sedatives
12 Pharmaceutical Solutions
13 Chlorhexidine gluconate

Interventional clinical trials:

(show top 50) (show all 58)
# Name Status NCT ID Phase Drugs
1 Medium Cost Effectiveness of Automated Non-Invasive Ventilation Outpatient Set Up vs Standard Fixed Level Non-Invasive Ventilation Inpatient Set Up In Obese Patients With Chronic Respiratory Failure Completed NCT02342899 Phase 3
2 Effects of Acetazolamide on the Duration of Mechanical Ventilation in Patients With Metabolic Alkalosis. Phase III Multicenter Double-blinded Clinical Trial. Completed NCT01499485 Phase 3 Acetazolamide;Placebo
3 A Clinical Trial to Optimise Patient-ventilator Interaction in Patients With Chronic Respiratory Failure Completed NCT01371149 Phase 2
4 Crossover, Double-blind, Phase 2 Study of AD981 Versus Placebo in Obesity Hypoventilation Syndrome Recruiting NCT05448443 Phase 2 AD981
5 Randomized Trial Comparing Telemedicine Monitoring and Titration in Patients Initiating Non-invasive Ventilation With Usual Care (TELEMOTINIV Study) Unknown status NCT01560741 Phase 1
6 Postoperative Complications in Patients With Obesity Hypoventilation Syndrome Based on Base Excess- OHBE Study: A National, Multicenter, Observational Cohort Study Unknown status NCT02980770
7 Interest of Using Nocturnal Polysomnography for Non-Invasive Ventilation (NIV) Settings' Optimization in Obesity-Hypoventilation Syndrome (OHS) Unknown status NCT00603096
8 Response to NonInvasive Mechanical Ventilation According to the Breathing Pattern Unknown status NCT01991535
9 PHOX2B Mutation-Confirmed Congenital Central Hypoventilation Syndrome in A Chinese Family: Presentations From Newborn to Adulthood Unknown status NCT00652964
10 Ketogenic Diet for Obesity Hypoventilation Syndrome Completed NCT04108819
11 Prevalence of Obesity Hypoventilation Syndrome in Subjects With Obesity Referred to Clinical (Medical Analysis) Laboratories for Regular Follow-up Completed NCT01903135
12 Improvement of Cardiac Function and Neural Respiratory Drive Following Set up of Non-invasive Ventilation in Patients With Hypercapnic Respiratory Failure Caused by Obesity Hypoventilation Syndrome Completed NCT02699112
13 Respiratory Muscle Endurance in Obesity Hypoventilation Syndrome; Evaluation by Incremental Load Test Completed NCT04835558
14 The Obesity-Hypoventilation Syndrome: A Study Of Clinical Characteristics And Predictive Factors Of Response To Treatment With Continuous Positive Airway Pressure (CPAP) And Non-Invasive Ventilation (NIV) Completed NCT00938977
15 Impact of Non-intentional Leaks on Breathing Pattern and Work of Breathing During Non-invasive Ventilation: Study in Awakened Healthy Subjects and Awakened Obesity Hypoventilation Syndrome(OHS)Patients and During the Sleep in OHS Patients. Completed NCT00983411
16 Randomized Controlled Trial Evaluating the Feasibility of AVAPS-AE vs. CPAP vs.Bilevel Pressure Support Ventilation in Obesity Hypoventilation Syndrome Completed NCT01368614
17 Clinical Benefits and Tolerance to a New Ventilatory Mode in Patients With Obesity Hypoventilation Syndrome (OHS). Completed NCT01757444
18 Comparison of Two Noninvasive Positive Pressure Ventilation Devices Using Target Volume Modes in Obesity Hypoventilation Syndrome (OHS): A Pilot Randomized Crossover Controlled Trial Completed NCT01748656
19 A Trial of Rehabilitation in Obesity Hypoventilation Syndrome (OHS) Completed NCT01483716
20 Mid-and Long-term Efficacy of Ventilation Non-invasive and Continuos Positive Airway Pressure in Obesity Hypoventilation Syndrome Completed NCT01405976
21 Prevalence Rate, and Clinical Characteristics of Obesity Hypoventilation Syndrome Via Screening Patients Admitted to Medical Intensive Care Units Completed NCT02934581
22 PAP Therapy Compliance in Patients With Obesity Hypoventilation Syndrome Completed NCT03449641
23 Multi-center, National, Randomized, Exploratory Study Evaluating Telemonitoring and Experimentation in Telemedicine for the Improvement of Healthcare Pathways (ETAPES Program) Compared to Standard of Care in Patients With Chronic Respiratory Failure Receiving Non-invasive Home Ventilation (e-VENT) Completed NCT04615078
24 Obesity in Sleep Medicine - Focusing on OHS Phenotypes Completed NCT04570540
25 Effectiveness Monitoring of Home Non-invasive Mechanical Ventilation by Pressure and Flow-time Signals Analysis Integrated on Digital Diagnosis Platform. Completed NCT03085537
26 Contribution of Average Volume Assured Pressure Support (AVAPS) to Efficacy of bi-Level Pressure Support Nocturnal Ventilation and Impact on Sleep Structure Completed NCT00479284
27 Use of Ventilator Monitoring for Early Detection of Exacerbations of Chronic Lung Disease Completed NCT01644162
28 Usefulness of Transcutaneous Capnography to Assess Residual Hypoventilation in Obesity-Hypoventilation Syndrom Treated by Non Invasive Ventilation at Home : a Prospective Study Completed NCT03572712
29 Effect of Auto-trilevel Ventilator on Patients With Obstructive Sleep Apnea Hypopnea Syndrome and Obesity Completed NCT01553227
30 Factors Associated With Chronic Respiratory Failure in Obesity: A Cross-sectional Study Completed NCT01380418
31 A Pilot Study to Investigate the Physiological and Clinical Effects of Heated Humidification During Non-Invasive Ventilation Completed NCT01372072
32 The Debated Role of Sleep Studies in Patients Under Established Home Mechanical Ventilation Completed NCT03506906
33 Multimodal Measurement of Respiratory Muscle Strength by Using Volitional and Non-volitional Tests in Patients With Obesity Hypoventilation Syndrome (OHS), Obesity-associated Hypoventilation and OHS-Risk-Patients to Evaluate Pathophysiological Determinants and Predictors for the Presence of a Sleep-related Hypoventilation Requiring Treatment in Obese Patients Recruiting NCT03854058
34 PREVALENCE OF OBESITY-HYPOVENTILATION SYNDROME IN PATIENTS WITH METABOLIC SYNDROME Recruiting NCT04839419
35 Effects of Exercise Training on Exercise Capacity and Sleep Quality in Patients With Obesity Hypoventilation Syndrome Recruiting NCT05398068
36 Evaluation of An Optical Measurement Algorithm Combined With Patient and Provider Input to Reduce Mask Exchanges During Initial Positive Airway Pressure Therapy Recruiting NCT04688125
37 A Non-Interventional Pilot Study to Explore the Role of Gut Flora in Obesity Recruiting NCT04100616
38 Prevalence of Right Ventricular Dysfunction in Acute Exacerbation of Chronic Respiratory Diseases and Its Impact on Outcomes Recruiting NCT04098094
39 Medico-economic and Quality of Life Evaluations in Obese Patients Followed by Medical Analysis Laboratories Recruiting NCT03861468
40 Pathophysiology of Hypoventilation in Obesity and Effects of Bariatric Intervention: PHOEBI Study Recruiting NCT04025528
41 Remote Monitoring to Improve Low Adherence in Non-invasive Ventilation: READ-NIV Trial Recruiting NCT04884165
42 Does Domiciliary Nasal High Flow (NHF) Therapy Improve Patient Outcomes in Chronic Hypercapnic Respiratory Failure (CHRF) in the United Kingdom (UK): A Pre and Post Interventional Study Recruiting NCT05167201
43 Effectiveness of Noninvasive Ventilation Adjusted Automatically in the Obesity Hypoventilation Syndrome Active, not recruiting NCT04327336
44 Evaluation of Effects of Positive End-expiratory Pressure (PEEP) on Lung and Heart Functions in Spontaneous Breathing Obese Subjects. Enrolling by invitation NCT02523352
45 "Mid- and Long-term Effectiveness of Positive Airway Pressure in OHS After an Acute-on-chronic Hypercapnic Respiratory Failure" Not yet recruiting NCT04317326
46 Evaluation of High Velocity Nasal Insufflation in Management of Respiratory Failure in Patients With Overlap Syndrome. Not yet recruiting NCT05190458
47 Impact of Noninvasive Ventilation on Resting Energy Expenditure in Patients With Obesity Hypoventilation Syndrome Treated by Long-term Home Noninvasive Ventilation. Suspended NCT04474587
48 Predictive Factors of Obesity-hypoventilation Syndrome (OHS) Among Obese Subjects- ETUDE COHYPOB - Terminated NCT02021448
49 Obesity Hypoventilation Syndrome Prevalence Study Terminated NCT01964339
50 Toffee Full Face and Toffee Nasal Mask Evaluation in Obesity Hypoventilation Syndrome (NZ) Terminated NCT02486380

Search NIH Clinical Center for Obesity-Hypoventilation Syndrome

Genetic Tests for Obesity-Hypoventilation Syndrome

Anatomical Context for Obesity-Hypoventilation Syndrome

Organs/tissues related to Obesity-Hypoventilation Syndrome:

MalaCards : Heart, Lung, Medulla Oblongata, Spinal Cord, Tonsil, Brain, Hypothalamus

Publications for Obesity-Hypoventilation Syndrome

Articles related to Obesity-Hypoventilation Syndrome:

(show top 50) (show all 905)
# Title Authors PMID Year
1
OBESITY-HYPOVENTILATION SYNDROME IN SIBLINGS. 62 57
14178614 1964
2
[Obesity and respiratory disorders]. 53 62
19127895 2008
3
Hyperleptinaemia, respiratory drive and hypercapnic response in obese patients. 53 62
17459895 2007
4
Long-term non-invasive ventilation increases chemosensitivity and leptin in obesity-hypoventilation syndrome. 53 62
17189682 2007
5
Leptin prevents respiratory depression in obesity. 53 62
10228114 1999
6
Obesity-associated sleep hypoventilation and increased adverse postoperative bariatric surgery outcomes in a large clinical retrospective cohort. 62
35959952 2022
7
Use of Positive Airway Pressure in the Treatment of Hypoventilation. 62
36333077 2022
8
Noninvasive ventilation in New Zealand: a national prevalence survey. 62
36326217 2022
9
A late presentation of TPM3 myopathy presenting as sleep hypoventilation in the setting of acute demyelinating encephalomyelitis. 62
35912694 2022
10
A Novel Nomogram and Online Calculator for Predicting the Risk of Obesity Hypoventilation Syndrome in Bariatric Surgery Candidates. 62
36334251 2022
11
Veno-venous extracorporeal membrane oxygenation rescue for pulmonary hypertension and hypoxemic respiratory failure to obesity hypoventilation syndrome: a case report. 62
35610191 2022
12
Plasma exosomes in obesity hypoventilation syndrome patients drive lung cancer cell malignant properties: Effect of long-term adherent CPAP treatment. 62
35811031 2022
13
Gender differences in obesity hypoventilation syndrome: a concise narrative review. 62
36315241 2022
14
[FROM OPTIC NERVE EDEMA TO POLYSOMNOGRAPHY - ANOTHER WAY TO DIAGNOSE OBSTRUCTIVE SLEEP APNEA]. 62
36315213 2022
15
Domiciliary noninvasive ventilation for chronic respiratory diseases. 62
36267521 2022
16
A Clinical Encounter With Pickwickian Syndrome. 62
36225419 2022
17
Comparing the influence of foot reflexology and fasting mimicking diet on quality of life and sleep quality in obesity hypoventilation syndrome. 62
36173670 2022
18
Leptin-mediated neural targets in obesity hypoventilation syndrome. 62
35778900 2022
19
Novel Treatment of Ventilator Dyssynchrony From Central Alveolar Hypoventilation Syndrome Utilizing Scheduled 5-Hydroxytryptamine-3 Receptor Antagonist. 62
36258708 2022
20
Cost-effectiveness of outpatient versus inpatient non-invasive ventilation setup in obesity hypoventilation syndrome: the OPIP trial. 62
36342884 2022
21
A novel case of central hypoventilation syndrome or just heavy breathing? 62
35713175 2022
22
Residual hypoxemia in obesity-hypoventilation syndrome: quantification of the ventilation/perfusion imbalance. 62
34514514 2022
23
Obesity hypoventilation syndrome in bariatric surgery patients: an underestimated disease. 62
35644806 2022
24
Obesity Hypoventilation Syndrome and Postsurgical Outcomes in a Bariatric Surgery Cohort. 62
35538187 2022
25
Tracheobronchomalacia and Excessive Dynamic Airway Collapse: Current Concepts and Future Directions. 62
35522576 2022
26
The Overlap of Obesity-Hypoventilation Syndrome and Obstructive Sleep Apnea: How to Treat? 62
35312564 2022
27
Non-invasive ventilation using a novel ventilator and non-vented full-face mask for patients with respiratory failure during the COVID-19 pandemic: Report of three cases. 62
35431171 2022
28
Portuguese adaptation of the S3-non-invasive ventilation (S3-NIV) questionnaire for home mechanically ventilated patients. 62
33388296 2022
29
The prevalence of non-invasive ventilation and long-term oxygen treatment in Helsinki University Hospital area, Finland. 62
35752824 2022
30
Mutations of PHOX2B Gene in Patients of Obesity Hypoventilation Syndrome in Central India. 62
35982870 2022
31
Respiratory Muscle Endurance in Obesity Hypoventilation Syndrome. 62
35318239 2022
32
The Influence of Obesity Hypoventilation Syndrome on the Outcomes of Patients With Diabetic Ketoacidosis. 62
35733497 2022
33
Comparison of Percutaneous Coronary Intervention Outcomes Among Patients With Obstructive Sleep Apnea, Chronic Obstructive Pulmonary Disease Overlap, and Pickwickian Syndrome (Obesity Hypoventilation Syndrome). 62
35686280 2022
34
Usefulness of P0.1 in the Follow-Up of Individuals With Air Trapping and Home Noninvasive Ventilation and CPAP. 62
35610030 2022
35
Cardiopulmonary coupling and serum cardiac biomarkers in obesity hypoventilation syndrome and obstructive sleep apnea with morbid obesity. 62
34879904 2022
36
Risk factors associated with pulmonary hypertension in obesity hypoventilation syndrome. 62
34755598 2022
37
Effectiveness of CPAP vs. Noninvasive Ventilation Based on Disease Severity in Obesity Hypoventilation Syndrome and Concomitant Severe Obstructive Sleep Apnea. 62
35312607 2022
38
Haematocrit level in obesity hypoventilation syndrome: a predictor of mortality? 62
34047903 2022
39
Effect of different modes of positive airway pressure treatment on obesity hypoventilation syndrome: a systematic review and network meta-analysis. 62
35272117 2022
40
Obstructive sleep apnoea/hypopnoea syndrome and obesity hypoventilation syndrome in over 16s: summary of NICE guidance. 62
35264334 2022
41
Severity stages of obesity-related breathing disorders - a cross-sectional cohort study. 62
35051737 2022
42
Interactive Effect of Combined Intermittent and Sustained Hypoxia and High-Fat Diet on the Colonic Mucosal Microbiome and Host Gene Expression in Mice. 62
36111259 2022
43
Results of CPAP Titration and Short-Term Adherence Rates in Patients with Obesity Hypoventilation Syndrome and Mild/Moderate Obstructive Sleep Apnea. 62
35733818 2022
44
The Combination of Betahistine and Oxybutynin Increases Respiratory Control Sensitivity (Loop Gain) in People with Obstructive Sleep Apnea: A Randomized, Placebo-Controlled Trial. 62
35698591 2022
45
Evaluation of the Effects of Noninvasive Ventilation on Blood Gas and Depression Levels of Patients with Obesity Hypoventilation Syndrome. 62
36393827 2022
46
Characteristics of Obese Patients with Acute Hypercapnia Respiratory Failure Admitted in the Department of Pneumology: An Observational Study of a North African Population. 62
35223103 2022
47
A pilot randomized trial comparing CPAP vs bilevel PAP spontaneous mode in the treatment of hypoventilation disorder in patients with obesity and obstructive airway disease. 62
34170241 2022
48
Monitoring Long Term Noninvasive Ventilation: Benefits, Caveats and Perspectives. 62
35665357 2022
49
Sex differences in patients with obesity hypoventilation syndrome: Do they really exist? 62
35229038 2022
50
Impact of Obesity in Critical Illness. 62
34364868 2021

Variations for Obesity-Hypoventilation Syndrome

Expression for Obesity-Hypoventilation Syndrome

Search GEO for disease gene expression data for Obesity-Hypoventilation Syndrome.

Pathways for Obesity-Hypoventilation Syndrome

Pathways related to Obesity-Hypoventilation Syndrome according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.36 RETN LEP IL6 ADIPOQ
2 11.54 LEP IL6
3 11.41 LEP IL6 ADIPOQ
4 11.36 LEP IL6
5 11.23 IL6 CCL5
6 11.08 IL6 CCL5
7 11.04 RETN LEP IL6 ADIPOQ
8 10.99 LEP IL6 ADIPOQ
9 10.77 LEP ADIPOQ
10 10.47 LEP IL6 ADIPOQ

GO Terms for Obesity-Hypoventilation Syndrome

Cellular components related to Obesity-Hypoventilation Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.65 RETN LEP IL6 CCL5 ADIPOQ
2 extracellular space GO:0005615 9.32 RETN LEP IL6 CCL5 ADIPOQ

Biological processes related to Obesity-Hypoventilation Syndrome according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10 RETN LEP IL6 CCL5 ADIPOQ
2 glucose homeostasis GO:0042593 9.91 ADIPOQ IL6 LEP
3 glucose metabolic process GO:0006006 9.85 LEP ADIPOQ
4 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.85 LEP IL6 CCL5
5 negative regulation of fat cell differentiation GO:0045599 9.84 IL6 ADIPOQ
6 positive regulation of smooth muscle cell proliferation GO:0048661 9.83 IL6 CCL5
7 fatty acid beta-oxidation GO:0006635 9.81 LEP ADIPOQ
8 monocyte chemotaxis GO:0002548 9.8 IL6 CCL5
9 positive regulation of interleukin-8 production GO:0032757 9.8 LEP IL6 ADIPOQ
10 regulation of angiogenesis GO:0045765 9.78 LEP IL6
11 response to nutrient GO:0007584 9.73 LEP ADIPOQ
12 positive regulation of T cell proliferation GO:0042102 9.73 CCL5 IL6 LEP
13 negative regulation of lipid storage GO:0010888 9.71 LEP IL6
14 regulation of insulin secretion GO:0050796 9.63 LEP IL6 CCL5
15 response to nutrient levels GO:0031667 9.57 LEP ADIPOQ
16 response to activity GO:0014823 9.43 LEP IL6 ADIPOQ
17 positive regulation of receptor signaling pathway via JAK-STAT GO:0046427 9.1 LEP IL6 CCL5

Molecular functions related to Obesity-Hypoventilation Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.35 IL6 CCL5 ADIPOQ
2 hormone activity GO:0005179 9.1 RETN LEP ADIPOQ

Sources for Obesity-Hypoventilation Syndrome

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....