MCID: OBS168
MIFTS: 25

Obsolete: Atypical Teratoid/rhabdoid Tumor

Categories: Rare diseases

Aliases & Classifications for Obsolete: Atypical Teratoid/rhabdoid Tumor

MalaCards integrated aliases for Obsolete: Atypical Teratoid/rhabdoid Tumor:

Name: Obsolete: Atypical Teratoid/rhabdoid Tumor 59
at/rt 59

Classifications:



External Ids:

Orphanet 59 ORPHA251891

Summaries for Obsolete: Atypical Teratoid/rhabdoid Tumor

MalaCards based summary : Obsolete: Atypical Teratoid/rhabdoid Tumor, also known as at/rt, is related to atypical teratoid rhabdoid tumor and rhabdoid tumor predisposition syndrome 1. An important gene associated with Obsolete: Atypical Teratoid/rhabdoid Tumor is TP53 (Tumor Protein P53). The drugs Cisplatin and Methotrexate have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and whole blood.

Related Diseases for Obsolete: Atypical Teratoid/rhabdoid Tumor

Diseases related to Obsolete: Atypical Teratoid/rhabdoid Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 20)
# Related Disease Score Top Affiliating Genes
1 atypical teratoid rhabdoid tumor 12.3
2 rhabdoid tumor predisposition syndrome 1 11.6
3 rhabdoid cancer 10.4
4 medulloblastoma 10.1
5 ewing's family of tumors 10.0
6 hemangiopericytoma, malignant 9.9
7 astrocytoma 9.9
8 grade iii astrocytoma 9.9
9 lipid metabolism disorder 9.9
10 benign ependymoma 9.9
11 ependymoma 9.9
12 hydrocephalus 9.7
13 ganglioneuroblastoma 9.7
14 mutism 9.7
15 medulloepithelioma 9.7
16 supratentorial primitive neuroectodermal tumor 9.7
17 ependymoblastoma 9.7
18 fatty liver disease 9.7
19 congenital hydrocephalus 9.7
20 embryonal tumor with multilayered rosettes 9.7

Graphical network of the top 20 diseases related to Obsolete: Atypical Teratoid/rhabdoid Tumor:



Diseases related to Obsolete: Atypical Teratoid/rhabdoid Tumor

Symptoms & Phenotypes for Obsolete: Atypical Teratoid/rhabdoid Tumor

Drugs & Therapeutics for Obsolete: Atypical Teratoid/rhabdoid Tumor

Drugs for Obsolete: Atypical Teratoid/rhabdoid Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 79)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 3 15663-27-1 84093 441203 2767
2
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
3
leucovorin Approved Phase 3 58-05-9 143 6006
4
Vincristine Approved, Investigational Phase 3 57-22-7, 2068-78-2 5978
5
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
6
Etoposide Approved Phase 3 33419-42-0 36462
7
Carboplatin Approved Phase 3 41575-94-4 10339178 498142 38904
8
Levoleucovorin Approved, Investigational Phase 3 68538-85-2
9
Sargramostim Approved, Investigational Phase 3 83869-56-1, 123774-72-1
10
Thiotepa Approved, Investigational Phase 3 52-24-4 5453
11
Lenograstim Approved, Investigational Phase 3 135968-09-1
12
Folic acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
13
Calcium Approved, Nutraceutical Phase 3 7440-70-2 271
14
Emodepside Investigational, Vet_approved Phase 3 155030-63-0
15 Alkylating Agents Phase 3
16 Folic Acid Antagonists Phase 3
17 Antineoplastic Agents, Phytogenic Phase 3
18 Nucleic Acid Synthesis Inhibitors Phase 3
19 Tubulin Modulators Phase 3
20 Vitamin B9 Phase 3
21 Folate Phase 3
22 Immunosuppressive Agents Phase 3
23 Vitamin B Complex Phase 3
24 Topoisomerase Inhibitors Phase 3
25 Dermatologic Agents Phase 3
26 Immunologic Factors Phase 3
27 Antimitotic Agents Phase 3
28 Antimetabolites, Antineoplastic Phase 3
29 Etoposide phosphate Phase 3
30 Antirheumatic Agents Phase 3
31 Antimetabolites Phase 3
32 Antineoplastic Agents, Alkylating Phase 3
33 Trace Elements Phase 3
34 Hormones Phase 3
35 Micronutrients Phase 3
36 Antidotes Phase 3
37 Vitamins Phase 3
38 Adjuvants, Immunologic Phase 3
39 Hematinics Phase 3
40 Protective Agents Phase 3
41 Keratolytic Agents Phase 3
42 Nutrients Phase 3
43 Podophyllotoxin Phase 3 518-28-5
44 Calcium, Dietary Phase 3
45 Bone Density Conservation Agents Phase 3
46
Hydrocortisone Approved, Vet_approved Phase 2 50-23-7 5754
47
Cytarabine Approved, Experimental, Investigational Phase 2 147-94-4, 65-46-3 6253
48
Dactinomycin Approved, Investigational Phase 2 50-76-0 457193 2019
49
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
50
Hydrocortisone acetate Approved, Vet_approved Phase 2 50-03-3

Interventional clinical trials:

(show all 18)
# Name Status NCT ID Phase Drugs
1 Systemic Chemotherapy, Second Look Surgery and Conformal Radiation Therapy Limited to the Posterior Fossa and Primary Site for Children >/= to 8 Months and <3 Years With Non-metastatic Medulloblastoma: A Children&Apos;s Oncology Group Phase III Study Completed NCT00006461 Phase 3 cisplatin;cyclophosphamide;vincristine sulfate;etoposide
2 Treatment of Atypical Teratoid/Rhabdoid Tumors (AT/RT) of the Central Nervous System With Surgery, Intensive Chemotherapy, and 3-D Conformal Radiation Active, not recruiting NCT00653068 Phase 3 Carboplatin;Cisplatin;Cyclophosphamide;Etoposide;Leucovorin Calcium;Methotrexate;Thiotepa;Vincristine Sulfate
3 A Prospective, Multicentre Trial on the Value of 18F-FET PET in the Post-therapeutic Evaluation of Childhood Brain Tumours Unknown status NCT03216148 Phase 2
4 A Phase II Study of Intrathecal and Systemic Chemotherapy With Radiation Therapy for Children With Central Nervous System Atypical Teratoid/Rhabdoid Tumor (AT/RT) Tumor Completed NCT00084838 Phase 2 cisplatin;cyclophosphamide;cytarabine;dexrazoxane hydrochloride;doxorubicin hydrochloride;etoposide;leucovorin calcium;methotrexate;temozolomide;therapeutic hydrocortisone;vincristine sulfate;Dactinomycin
5 Phase 2 Study of Alisertib as a Single Agent in Recurrent or Progressive Central Nervous System (CNS) Atypical Teratoid Rhabdoid Tumors (AT/RT) and Extra-CNS Malignant Rhabdoid Tumors (MRT) and in Combination Therapy in Newly Diagnosed AT/RT Recruiting NCT02114229 Phase 2 alisertib;methotrexate;cisplatin;carboplatin;cyclophosphamide;etoposide;topotecan;vincristine
6 A Phase II Study of Intraventricular Methotrexate With Systemic Topotecan and Cyclophosphamide in Children With Recurrent or Progressive Malignant Brain Tumors Recruiting NCT02684071 Phase 2 Intra thecal methotrexate;topotecan;cyclophosphamide
7 NYU 05-40 PBMTC ONC-032P:High Dose Temozolomide,Thiotepa and Carboplatin With Autologous Stem Cell Rescue (ASCR) Followed by Continuation Therapy With 13-cis-retinoic Acid in Patients With Recurrent/Refractory Malignant Brain Tumors Active, not recruiting NCT00528437 Phase 2 temozolomide, thiotepa, carboplatin, 13-cis-retinoic acid
8 A Phase II Trial of Poly-ICLC in the Management of Recurrent Pediatric Low Grade Gliomas Active, not recruiting NCT01188096 Phase 2 Poly ICLC
9 Phase I Study of Methotrexate Infusion Into the Fourth Ventricle in Children With Recurrent Malignant Fourth Ventricular Brain Tumors Completed NCT02458339 Phase 1 Methotrexate
10 Vitrification Versus Slow Freezing of Human Day 3 Embryos Unknown status NCT00710723
11 Effects of Combined Resistance and Aerobic Training vs Aerobic Training on Cognition and Mobility Following Stroke Completed NCT01712724
12 Health Benefits of Aerobic and Resistance Training in Individuals With Type 2 Diabetes Completed NCT00458133
13 Cardiovascular and Cardiorespiratory Coupling After Different Types of Training and Detraining Completed NCT02441192
14 Enhancing Cognition and Functional Independence in Senior Women With Mild Cognitive Impairment: A Randomized Trial of Aerobic vs. Resistance Training Completed NCT00958867
15 Methotrexate Infusion Into the Fourth Ventricle in Children With Malignant Fourth Ventricular Brain Tumors: A Pilot Study Completed NCT01737671 Early Phase 1 Methotrexate;Leucovorin
16 Fetal Early Non-invasive Biomarkers of Chronic Maternal Stress During Pregnancy Resulting in Alterations of Infant Cognitive Development Recruiting NCT03389178
17 A Multi-centre, Controlled, Prospective Cohort Study Investigating the Accuracy of the Glycologic Limited Test Kit to Detect Bacterial Infection in Chronic and Delayed-healing Wounds. Recruiting NCT03883230
18 Relationship Between C. Difficile Toxins' Serum Level With C. Difficile Infection Not yet recruiting NCT03586206

Search NIH Clinical Center for Obsolete: Atypical Teratoid/rhabdoid Tumor

Genetic Tests for Obsolete: Atypical Teratoid/rhabdoid Tumor

Anatomical Context for Obsolete: Atypical Teratoid/rhabdoid Tumor

MalaCards organs/tissues related to Obsolete: Atypical Teratoid/rhabdoid Tumor:

41
Brain, Testes, Whole Blood, Prostate, Liver, Breast, Bone

Publications for Obsolete: Atypical Teratoid/rhabdoid Tumor

Articles related to Obsolete: Atypical Teratoid/rhabdoid Tumor:

(show top 50) (show all 1351)
# Title Authors PMID Year
1
Oxidation Behaviors of Co, Cr, and Ni Nanopowders: A Real-Time Synchrotron X-ray Scattering Study. 38
31383172 2020
2
Structural, magnetic, optical properties and cation distribution of nanosized Ni0.3Cu0.3Zn0.4TmxFe2-xO4 (0.0 ≤ x ≤ 0.10) spinel ferrites synthesized by ultrasound irradiation. 38
31085087 2019
3
Evaluation of Enterococcus faecium NRRL B-2354 as a surrogate for Salmonella during cocoa powder thermal processing. 38
31027767 2019
4
Effects of processing and storage conditions on volatile composition and odor characteristics of blackcurrant (Ribes nigrum) juices. 38
31151596 2019
5
Effect of α-Fe₂O₃ Phase on the Magnetic Interactions in Nickel Ferrite (NiFe₂O₄) Nanoparticles. 38
30961726 2019
6
Transition-Metal-Free Oxidative Cross-Coupling of Triorganoindium Reagents with Tetrahydroisoquinolines. 38
31294552 2019
7
Stability of Insulin Detemir Injection in Different Primary Packaging Systems at Room Temperature. 38
31409202 2019
8
Room-Temperature Stimulated Emission and Lasing in Recrystallized Cesium Lead Bromide Perovskite Thin Films. 38
31402527 2019
9
Effect of trehalose on the preservation of freeze-dried mice spermatozoa at room temperature. 38
31118350 2019
10
Guidelines for the Use of Deuterium Oxide (D2O) in 1H NMR Metabolomics. 38
31397558 2019
11
Low-Temperature Solution Synthesis of Au-Modified ZnO Nanowires for Highly Efficient Hydrogen Nanosensors. 38
31385698 2019
12
Tunable Giant Anomalous Hall Angle in Perpendicular Multilayers by Interfacial Orbital Hybridization. 38
31246392 2019
13
Bactericidal efficacies of food additive grade calcium hydroxide toward Legionella pneumophila. 38
31292348 2019
14
A microporous metal-organic framework with naphthalene diimide groups for high methane storage. 38
31267121 2019
15
Pre-analytical stability of novel cerebrospinal fluid biomarkers. 38
31348908 2019
16
The effects of six-week resistance, aerobic and combined exercises on the pro-inflammatory and anti-inflammatory markers in overweight patients with moderate haemophilia A: A randomized controlled trial. 38
31131517 2019
17
Cryopreserved cord blood mononuclear cells in DMSO are healthy for at least 6 hours after thawing. 38
31327732 2019
18
Variability of cytokine concentration in whole blood serum and bronchoalveolar lavage over time. 38
31276936 2019
19
Unbiased Metabolic Profiling Predicts Sensitivity of High MYC-Expressing Atypical Teratoid/Rhabdoid Tumors to Glutamine Inhibition with 6-Diazo-5-Oxo-L-Norleucine. 38
31300448 2019
20
Two-year-supervised resistance training prevented diabetes incidence in people with prediabetes: A randomised control trial. 38
30768758 2019
21
DNA integrity and methylation changes of mouse spermatozoa following prolonged incubation. 38
30920003 2019
22
A nanocomposite consisting of ZnO decorated graphene oxide nanoribbons for resistive sensing of NO2 gas at room temperature. 38
31327055 2019
23
Towards a unified protocol for handling of CSF before β-amyloid measurements. 38
31324260 2019
24
Superior triethylamine detection at room temperature by {-112} faceted WO3 gas sensor. 38
31325692 2019
25
Effect of protein cryoconcentration and processing conditions on kinetics of dimer formation for a monoclonal antibody: A case study on bioprocessing. 38
31063635 2019
26
Housing temperature affects the acute and chronic metabolic adaptations to exercise in mice. 38
31297830 2019
27
Construction of ZnO/SnO2 Heterostructure on Reduced Graphene Oxide for Enhanced Nitrogen Dioxide Sensitive Performances at Room Temperature. 38
31262171 2019
28
Vitrification of equine expanded blastocysts following puncture with or without aspiration of the blastocoele fluid. 38
30417442 2019
29
Structural, optical and magnetic properties of Tm3+ substituted cobalt spinel ferrites synthesized via sonochemical approach. 38
30833194 2019
30
Evaluation of a commercial liquid-chromatography high-resolution mass-spectrometry method for the determination of hepcidin-25. 38
31015783 2019
31
Platinum-catalyzed reactions between Si-H groups as a new method for cross-linking of silicones. 38
31107495 2019
32
Anti-epidermal growth factor receptor therapy in combination with chemoradiotherapy for the treatment of locally advanced anal canal carcinoma: Results of a phase I dose-escalation study with panitumumab (FFCD 0904). 38
31185328 2019
33
Role of early and aggressive post-operative radiation therapy in improving outcome for pediatric central nervous system atypical teratoid/rhabdoid tumor. 38
30982172 2019
34
Evaluation of fecal microRNA stability in healthy cats. 38
31241203 2019
35
Assessment of the impact of different fecal storage protocols on the microbiota diversity and composition: a pilot study. 38
31253096 2019
36
Effect of temperature and time delay in centrifugation on stability of select biomarkers of nutrition and non-communicable diseases in blood samples. 38
31223262 2019
37
Effect of time and storage on toxic or pseudo-toxic change in canine neutrophils. 38
31237714 2019
38
Indium thiospinel In1-x□xIn2S4- structural characterization and thermoelectric properties. 38
31112177 2019
39
Molecular Pathology of Tumors of the Central Nervous System. 38
31124566 2019
40
Identification of a novel biomarker for pyridoxine-dependent epilepsy: Implications for newborn screening. 38
30663059 2019
41
Case-based review: atypical teratoid/rhabdoid tumor. 38
31386032 2019
42
Spinal Atypical rhabdoid teratoid tumor in an adult woman. A rare case report and review of the literature. 38
31082562 2019
43
Short-term stability of free metanephrines in plasma and whole blood. 38
31348754 2019
44
Efficient hydrolytic cleavage of DNA and antiproliferative effect on human cancer cells by two dinuclear Cu(II) complexes containing a carbohydrazone ligand and 1,10-phenanthroline as a coligand. 38
30887122 2019
45
Characterization of Phosphate Buffered Saline (PBS) in Frozen State and after Freeze-Drying. 38
31087169 2019
46
[Effects of physical training in patients with type 2 diabetes mellitus: a systematic review]. 38
31344211 2019
47
AlN/InAlN thin-film transistors fabricated on glass substrates at room temperature. 38
31000767 2019
48
Platelet enhancement of bacterial growth during room temperature storage: mitigation through refrigeration. 38
30980761 2019
49
Alternating electric field application induced non-contact and enzyme-free cell detachment. 38
30783819 2019
50
Controllable synthesis of MoS2@MoO2 nanonetworks for enhanced NO2 room temperature sensing in air. 38
30990493 2019

Variations for Obsolete: Atypical Teratoid/rhabdoid Tumor

ClinVar genetic disease variations for Obsolete: Atypical Teratoid/rhabdoid Tumor:

6
# Gene Variation Type Significance SNP ID GRCh37 Pos GRCh38 Pos
1 TP53 NM_000546.5(TP53): c.733G> A (p.Gly245Ser) single nucleotide variant Pathogenic rs28934575 17:7577548-7577548 17:7674230-7674230
2 ATRX NM_000489.5(ATRX): c.5579A> G (p.Asn1860Ser) single nucleotide variant Benign/Likely benign rs45439799 X:76856021-76856021 X:77600552-77600552

Expression for Obsolete: Atypical Teratoid/rhabdoid Tumor

Search GEO for disease gene expression data for Obsolete: Atypical Teratoid/rhabdoid Tumor.

Pathways for Obsolete: Atypical Teratoid/rhabdoid Tumor

GO Terms for Obsolete: Atypical Teratoid/rhabdoid Tumor

Sources for Obsolete: Atypical Teratoid/rhabdoid Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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