MCID: OBS004
MIFTS: 44

Obstructive Hydrocephalus

Categories: Neuronal diseases

Aliases & Classifications for Obstructive Hydrocephalus

MalaCards integrated aliases for Obstructive Hydrocephalus:

Name: Obstructive Hydrocephalus 12 54 15 70 32

Classifications:



External Ids:

Disease Ontology 12 DOID:14159
ICD9CM 34 331.4
MeSH 44 D006849
NCIt 50 C116347
SNOMED-CT 67 230746009
ICD10 32 G91.1
UMLS 70 C0549423

Summaries for Obstructive Hydrocephalus

MalaCards based summary : Obstructive Hydrocephalus is related to cellular ependymoma and subependymal giant cell astrocytoma. An important gene associated with Obstructive Hydrocephalus is FOXJ1 (Forkhead Box J1), and among its related pathways/superpathways are Neuroscience and Spinal Cord Injury. The drugs Cisplatin and Mesna have been mentioned in the context of this disorder. Affiliated tissues include pineal, brain and pituitary, and related phenotypes are behavior/neurological and growth/size/body region

Related Diseases for Obstructive Hydrocephalus

Diseases related to Obstructive Hydrocephalus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 442)
# Related Disease Score Top Affiliating Genes
1 cellular ependymoma 31.8 SYP NF2 GFAP
2 subependymal giant cell astrocytoma 31.3 TSC1 SYP MTOR GFAP ENO2
3 intracranial hypertension 31.2 PRL AQP4 AQP1
4 chiari malformation 30.7 SYP GFAP AQP1
5 head injury 30.4 PRL ENO2
6 neurilemmoma of the fifth cranial nerve 30.3 NF2 NF1
7 syringomyelia 30.2 NF1 GFAP AQP4
8 hydrocephalus 30.2 SYP PRL MTOR MPDZ GFAP FOXJ1
9 pineoblastoma 30.2 SYP GFAP AFP
10 brain edema 30.0 GFAP AQP4 AQP1
11 pineocytoma 30.0 SYP GFAP ENO2
12 intracranial cysts 30.0 GFAP ENO2
13 optic nerve disease 29.8 NF1 GFAP AQP4 AQP1
14 traumatic brain injury 29.8 GFAP ENO2 AQP4
15 brain injury 29.8 GFAP ENO2 AQP4
16 status epilepticus 29.7 MTOR GFAP ENO2
17 acoustic neuroma 29.7 NF2 NF1 AQP4 AQP1
18 hemangioblastoma 29.7 SYP GFAP ENO2
19 cowden syndrome 29.7 TSC1 NF2 NF1 MTOR
20 hemangioma 29.6 TSC1 SYP MTOR ENO2
21 neurilemmoma 29.5 NF2 NF1 GFAP ENO2
22 meningioma, familial 29.5 SYP NF2 NF1 GFAP
23 pilocytic astrocytoma 29.5 SYP OLIG2 NF1 MTOR GFAP
24 benign ependymoma 29.5 TSC1 SYP NF2 NF1 MTOR GFAP
25 central neurocytoma 29.4 SYP OLIG2 GFAP ENO2
26 cerebral degeneration 29.4 SYP OLIG2 GFAP FOXJ1 AQP4 AQP1
27 pineal gland cancer 29.1 SYP OLIG2 GFAP ENO2 AFP
28 tuberous sclerosis 29.1 TSC1 SYP NF2 NF1 MTOR GFAP
29 brain cancer 28.5 SYP OLIG2 NF2 NF1 GFAP ENO2
30 ciliary dyskinesia, primary, 43 11.2
31 hydrocephalus due to congenital stenosis of aqueduct of sylvius 11.2
32 hydrocephalus, congenital, 1 11.2
33 congenital communicating hydrocephalus 11.1
34 congenital hydrocephalus 11.1
35 megalencephaly-capillary malformation-polymicrogyria syndrome 11.0
36 arteriovenous malformation 10.4
37 meningitis 10.4
38 communicating hydrocephalus 10.4
39 extraventricular neurocytoma 10.3 SYP GFAP
40 desmoplastic infantile ganglioglioma 10.3 SYP GFAP
41 lung combined type small cell carcinoma 10.3 SYP GFAP
42 aneurysm 10.3
43 non-gestational ovarian choriocarcinoma 10.3 PRL AFP
44 dysferlinopathy 10.3 AQP4 AQP1
45 angiocentric glioma 10.3 SYP GFAP
46 ocular motor apraxia 10.3
47 thymus sarcomatoid carcinoma 10.3 SYP AFP
48 ovarian mixed germ cell neoplasm 10.3 MTOR AFP
49 medullomyoblastoma 10.3 SYP GFAP
50 hepatic angiomyolipoma 10.3 MTOR AFP

Comorbidity relations with Obstructive Hydrocephalus via Phenotypic Disease Network (PDN): (show all 18)


Acute Cystitis Alzheimer Disease
Brain Cancer Brain Compression
Cerebellum Cancer Cerebral Degeneration
Communicating Hydrocephalus Decubitus Ulcer
Deficiency Anemia Epilepsy, Focal, with Speech Disorder and with or Without Mental Retardation
Hypertension, Essential Parkinson Disease, Late-Onset
Pineal Gland Cancer Protein-Energy Malnutrition
Respiratory Failure Schizophreniform Disorder
Swallowing Disorders Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Obstructive Hydrocephalus:



Diseases related to Obstructive Hydrocephalus

Symptoms & Phenotypes for Obstructive Hydrocephalus

MGI Mouse Phenotypes related to Obstructive Hydrocephalus:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.35 AFP AQP1 AQP4 DUSP16 ENO2 FOXJ1
2 growth/size/body region MP:0005378 10.22 AQP1 AQP4 DUSP16 ENO2 FOXJ1 GFAP
3 cardiovascular system MP:0005385 10.2 AQP1 AQP4 CCDC85C DUSP16 FOXJ1 GFAP
4 mortality/aging MP:0010768 10.18 AFP AQP1 AQP4 CCDC85C DUSP16 FOXJ1
5 nervous system MP:0003631 10.1 AQP1 AQP4 CCDC85C ENO2 FOXJ1 GFAP
6 endocrine/exocrine gland MP:0005379 10.09 AFP AQP1 AQP4 MTOR NF1 NF2
7 neoplasm MP:0002006 9.87 AFP NF1 NF2 OLIG2 PLG PRL
8 renal/urinary system MP:0005367 9.7 AQP1 AQP4 MTOR NF1 NF2 PLG
9 respiratory system MP:0005388 9.65 AQP1 AQP4 ENO2 FOXJ1 MTOR NF1
10 vision/eye MP:0005391 9.28 AQP1 AQP4 GFAP MPDZ NF1 NF2

Drugs & Therapeutics for Obstructive Hydrocephalus

Drugs for Obstructive Hydrocephalus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved 15663-27-1 84093 441203 2767
2
Mesna Approved, Investigational 3375-50-6 598
3
Magnesium Sulfate Approved, Investigational, Vet_approved 7487-88-9 24083
4
Vincristine Approved, Investigational 2068-78-2, 57-22-7 5978
5
Mannitol Approved, Investigational 69-65-8 453 6251
6
Etoposide Approved 33419-42-0 36462
7
Cyclophosphamide Approved, Investigational 50-18-0, 6055-19-2 2907
8
Vitamin A Approved, Nutraceutical, Vet_approved 68-26-8, 11103-57-4 445354
9
Mafosfamide Investigational 88859-04-5
10 Retinol palmitate
11 Adjuvants, Immunologic
12 Alkylating Agents
13 Antirheumatic Agents
14 Immunosuppressive Agents
15 retinol
16 Etoposide phosphate
17 Immunologic Factors

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effects of Intrathoracic Pressure Regulation Therapy in Patients With Elevated Intracranial Pressure Due to Brain Injury or Intracranial Pathology Terminated NCT01824589 Phase 4
2 Pilot Study of Systemic and Intrathecal Chemotherapy Followed by Conformal Radiation for Infants With Brain Tumors Completed NCT00042367 Induction therapy (Regimen 1, Course 1, Cycle A1;Regimen 1, Course 1, Cycle A2 (Days 22 - 42);Cycle B;Regimen 1, Course 2;Intrathecal Mafosfamide;Regimen 1 Course 2, IT mafosfamide;Regimen 2, Course 1;Regimen 2, Course, 1, Cycle C1;Regimen 2, Course 2
3 Hypothalamic-pituitary Effects After Endoscopic Third Ventriculostomy Terminated NCT01675037

Search NIH Clinical Center for Obstructive Hydrocephalus

Genetic Tests for Obstructive Hydrocephalus

Anatomical Context for Obstructive Hydrocephalus

MalaCards organs/tissues related to Obstructive Hydrocephalus:

40
Pineal, Brain, Pituitary, Spinal Cord, Cerebellum, Lung, Prostate

Publications for Obstructive Hydrocephalus

Articles related to Obstructive Hydrocephalus:

(show top 50) (show all 2069)
# Title Authors PMID Year
1
Visual loss in tuberous sclerosis. 61 54
1745348 1991
2
Hydrocephalus Caused by Primary Fourth Ventricle Outlet Obstruction: Our Experience and Literature Review. 61
33444837 2021
3
Mis-diagnosed giant ovarian cyst and ventriculoperitoneal shunt malfunction. 61
33166567 2021
4
Transumbilical single-incision laparoscopically assisted ventriculoperitoneal shunting: a minimal invasive technique. 61
33452618 2021
5
Hemicraniectomy and externalized ventricular drain placement in a pediatric patient with myelin oligodendrocyte glycoprotein-associated tumefactive demyelinating disease. 61
33796928 2021
6
[Hydrocephalus]. 61
33762452 2021
7
Delayed Obstructive Hydrocephalus After Cardiac Surgery With Cardiopulmonary Bypass in a Patient With Cerebellar Infarction: A Case Report. 61
33783405 2021
8
Endoscopic Endonasal Transsphenoidal Approach for Third Ventriculostomy in the Management of Obstructive Hydrocephalus. 61
33710059 2021
9
Acute Presentation of Third Ventricular Cavernous Malformation following COVID-19 Infection in a Pregnant Woman: A Case Report. 61
33771616 2021
10
Paediatric arachnoid cysts: Surgical outcomes from a Singapore children's hospital. 61
33581782 2021
11
Endoscopic Third Ventriculostomy in Infants Less than One Year of Age: A Short Series of 14 Cases. 61
33652442 2021
12
Basilar artery occlusion presenting as sudden bilateral deafness: a case report. 61
33653404 2021
13
Acute Necrotizing Encephalopathy in a Four-Year-Old Boy. 61
33809853 2021
14
Acoustic neuroma presenting as a hypnic headache. 61
33687931 2021
15
Cerebellitis as a neurosurgical disease in pediatrics. 61
33581790 2021
16
The Third Eye Sees Double: Cohort Study of Clinical Presentation, Histology, Surgical Approaches, and Ophthalmic Outcomes in Pineal Region Germ Cell Tumors. 61
33722723 2021
17
A case of rapid deterioration in a subacute period after endoscopic third ventriculostomy. 61
33605824 2021
18
ETV for successful treatment of holocord syrinx with hydrocephalus: a case report. 61
31994420 2021
19
Risk Analysis and Management of Third Ventricular Colloid Cysts. 61
33246179 2021
20
Post-operative seizure after first time endoscopic third ventriculostomy in pediatric patients. 61
33599807 2021
21
Diagnosis and Therapeutic Management of Ventricular Gangliogliomas: An Illustrated Review. 61
33548530 2021
22
Diffusion Tensor Imaging-Based Analysis of Baseline Neurocognitive Function and Posttreatment White Matter Changes in Pediatric Patients With Craniopharyngioma Treated With Surgery and Proton Therapy. 61
32898610 2021
23
Management of Thromboembolic Complications During Aneurysm Coiling: 2-Dimensional Operative Video. 61
33571364 2021
24
Spinal Drop Metastasis of Glioblastoma-Two Case Reports, Clinicopathologic Features, Current Modalities of Evaluation, and Treatment with a Review of the Literature. 61
33161132 2021
25
Pineal Region Glioblastomas: Clinical Characteristics, Treatment, and Survival Outcome. 61
33186787 2021
26
Neuropsychiatric systemic lupus erythematosus with cerebellar vasculitis and obstructive hydrocephalus requiring decompressive craniectomy. 61
33021438 2021
27
Pre-operative headaches and obstructive hydrocephalus predict an extended length of stay following suboccipital decompression for pediatric Chiari I malformation. 61
32519127 2021
28
Choroid plexus NKCC1 mediates cerebrospinal fluid clearance during mouse early postnatal development. 61
33469018 2021
29
Visual acuity loss and sixth nerve palsy as the only manifestations of slit ventricle syndrome. 61
33478754 2021
30
Porencephalic cyst after endoscopic third ventriculostomy and Ommaya reservoir placement: case report and review of the literature. 61
33442758 2021
31
Fatal Distant Venous Epidural Hematoma Following Posterior Cranial Fossa Surgery in a Twelve-Year old Child. 61
33598375 2021
32
Management of Obstructive Hydrocephalus Associated with Pineal Region Cysts and Tumors and Its Implication in Long-Term Outcome. 61
33516866 2021
33
Expanding the Horizons of mTOR Inhibitors for Treating Subependymal Giant Cell Astrocytomas with Obstructive Hydrocephalus. 61
33508851 2021
34
[Diffuse subarachnoid haemorrhage with obstructive hydrocephalus in a 4-year-old girl]. 61
33526355 2021
35
Third Ventricle Cavernous Malformation and Obstructive Hydrocephalus Thought to Be a Colloid Cyst. 61
33010503 2021
36
Third ventricular colloid cyst causing acute hydrocephalus during early pregnancy: Clinical lessons from a case. 61
33654557 2021
37
Pediatric Fulminant Cerebellitis Is Still a Fatal Disease that We Know Little About! Two Case Reports and a Literature Review. 61
33454719 2021
38
Combined simultaneous endoscopic endonasal and microscopic transventricular surgery using a port retractor system for giant pituitary adenoma: A technical case report. 61
33767894 2021
39
Endoscopic Anatomy of Lateral and Third Ventricles: A must Know for Performing Endoscopic Third Ventriculostomy. 61
33642269 2021
40
Case Report: Untreatable Headache in a Child With Ventriculoperitoneal Shunt Managed by Use of New Non-invasive Intracranial Pressure Waveform. 61
33679296 2021
41
Endoscopic third ventriculostomy in children: problems and surgical outcome: analysis of 34 cases. 61
33407946 2021
42
Spontaneous regression of multiple intracranial capillary hemangiomas in a newborn-long-term follow-up and literature review. 61
33481102 2021
43
Artificial intelligence for automatic cerebral ventricle segmentation and volume calculation: a clinical tool for the evaluation of pediatric hydrocephalus. 61
33260138 2020
44
Fetal and postnatal MRI findings of Blake pouch remnant causing obstructive hydrocephalus. 61
33072233 2020
45
Acute Management of Gamma Knife Radiosurgery for Asymptomatic Obstructive Hydrocephalus Associated with Posterior Fossa Metastases. 61
32949796 2020
46
Unilateral mydriasis in a child with a ventriculoperitoneal shunt for obstructive hydrocephalus: a diagnostic dilemma. 61
33370982 2020
47
Pattern of head circumference growth following bidirectional Glenn in infants with single ventricle heart disease. 61
33303046 2020
48
Cranial Ultrasound Is an Important Tool in the Recognition of Life-Threatening Infratentorial Hemorrhage in Newborns. 61
33316833 2020
49
Entrapment of the temporal horn: case series and systematic review of literature. 61
33297607 2020
50
The one-step edge-to-edge technique in ventriculoperitoneal shunt. 61
33284048 2020

Variations for Obstructive Hydrocephalus

Expression for Obstructive Hydrocephalus

Search GEO for disease gene expression data for Obstructive Hydrocephalus.

Pathways for Obstructive Hydrocephalus

Pathways related to Obstructive Hydrocephalus according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.89 SYP NF2 NF1 GFAP ENO2
2 11.58 GFAP AQP4 AQP1
3 11.23 SYP OLIG2 GFAP
4 10.97 TSC1 NF2 NF1 MTOR
5 10.51 TSC1 MTOR

GO Terms for Obstructive Hydrocephalus

Cellular components related to Obstructive Hydrocephalus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 astrocyte end-foot GO:0097450 8.62 GFAP AQP4

Biological processes related to Obstructive Hydrocephalus according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 brain development GO:0007420 9.73 NF2 NF1 MTOR FOXJ1
2 positive regulation of glial cell proliferation GO:0060252 9.51 MTOR GFAP
3 response to nutrient levels GO:0031667 9.5 TSC1 PRL MTOR
4 water transport GO:0006833 9.49 AQP4 AQP1
5 negative regulation of macroautophagy GO:0016242 9.48 TSC1 MTOR
6 regulation of cell-matrix adhesion GO:0001952 9.46 TSC1 NF1
7 cerebral cortex development GO:0021987 9.43 TSC1 NF1 CCDC85C
8 multicellular organismal water homeostasis GO:0050891 9.4 AQP4 AQP1
9 negative regulation of cell size GO:0045792 9.37 TSC1 MTOR
10 cellular water homeostasis GO:0009992 9.16 AQP4 AQP1
11 positive regulation of stress fiber assembly GO:0051496 9.13 TSC1 NF2 MTOR
12 negative regulation of MAPK cascade GO:0043409 8.8 NF2 NF1 DUSP16

Molecular functions related to Obstructive Hydrocephalus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 water channel activity GO:0015250 8.62 AQP4 AQP1

Sources for Obstructive Hydrocephalus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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