MCID: OBS004
MIFTS: 38

Obstructive Hydrocephalus

Categories: Neuronal diseases

Aliases & Classifications for Obstructive Hydrocephalus

MalaCards integrated aliases for Obstructive Hydrocephalus:

Name: Obstructive Hydrocephalus 12 55 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:14159
ICD10 33 G91.1
ICD9CM 35 331.4
MeSH 44 D006849
NCIt 50 C116347
SNOMED-CT 68 230746009 82346000
UMLS 73 C0549423

Summaries for Obstructive Hydrocephalus

MalaCards based summary : Obstructive Hydrocephalus is related to ependymoma and chiari malformation. An important gene associated with Obstructive Hydrocephalus is PRL (Prolactin), and among its related pathways/superpathways is Neuroscience. The drugs Amphotericin B and deoxycholic acid have been mentioned in the context of this disorder. Affiliated tissues include brain, pituitary and bone, and related phenotypes are behavior/neurological and nervous system

Related Diseases for Obstructive Hydrocephalus

Diseases related to Obstructive Hydrocephalus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 185)
# Related Disease Score Top Affiliating Genes
1 ependymoma 31.4 GFAP SYP
2 chiari malformation 30.3 GFAP SYP
3 subependymal giant cell astrocytoma 29.9 GFAP SYP
4 hemangioblastoma 28.9 GFAP SYP
5 tuberous sclerosis 28.9 GFAP NF1 SYP
6 subependymoma 28.5 AQP4 GFAP SYP
7 pilocytic astrocytoma 28.0 GFAP NF1 SRGAP3 SYP
8 congenital non-communicating hydrocephalus 11.4
9 hydrocephalus due to congenital stenosis of aqueduct of sylvius 11.3
10 congenital communicating hydrocephalus 11.0
11 congenital hydrocephalus 10.9
12 hydrocephalus 10.9
13 sella turcica neoplasm 10.5 PRL SYP
14 tuberculum sellae meningioma 10.5 PRL SYP
15 vestibular disease 10.5 CRLF1 GJB6
16 central nervous system organ benign neoplasm 10.5 PRL SYP
17 cogan syndrome 10.4 CRLF1 GFAP
18 desmoplastic infantile ganglioglioma 10.4 GFAP SYP
19 extraventricular neurocytoma 10.4 GFAP SYP
20 lung combined type small cell carcinoma 10.4 GFAP SYP
21 cellular ependymoma 10.4 GFAP SYP
22 gangliocytoma 10.4 GFAP SYP
23 rhabdoid meningioma 10.4 GFAP SYP
24 pilomyxoid astrocytoma 10.4 GFAP SYP
25 chordoid meningioma 10.4 GFAP SYP
26 central nervous system primitive neuroectodermal neoplasm 10.4 GFAP SYP
27 subependymal glioma 10.4 GFAP SYP
28 granulosa cell tumor of the ovary 10.4 PRL SYP
29 dysembryoplastic neuroepithelial tumor 10.4 GFAP SYP
30 cerebral neuroblastoma 10.4 GFAP SYP
31 benign ependymoma 10.4 GFAP SYP
32 astroblastoma 10.4 GFAP SYP
33 cerebral ventricle cancer 10.4 GFAP SYP
34 cerebrum cancer 10.4 GFAP SYP
35 pineal gland cancer 10.4 GFAP SYP
36 melanotic neuroectodermal tumor 10.4 GFAP SYP
37 angiocentric glioma 10.4 GFAP SYP
38 supratentorial cancer 10.4 GFAP SYP
39 medulloepithelioma 10.4 GFAP SYP
40 pineocytoma 10.4 GFAP SYP
41 anaplastic ependymoma 10.3 GFAP SYP
42 childhood oligodendroglioma 10.3 GFAP SYP
43 tanycytic ependymoma 10.3 GFAP SYP
44 papillary ependymoma 10.3 GFAP SYP
45 pleomorphic xanthoastrocytoma 10.3 GFAP SYP
46 pineoblastoma 10.3 GFAP SYP
47 papilloma of choroid plexus 10.3 GFAP SYP
48 central neurocytoma 10.3 GFAP SYP
49 binswanger's disease 10.3 GFAP SYP
50 cystic teratoma 10.3 GFAP SYP

Comorbidity relations with Obstructive Hydrocephalus via Phenotypic Disease Network (PDN): (show all 18)


Acute Cystitis Alzheimer Disease
Brain Cancer Brain Compression
Cerebellum Cancer Cerebral Degeneration
Communicating Hydrocephalus Decubitus Ulcer
Deficiency Anemia Epilepsy, Focal, with Speech Disorder and with or Without Mental Retardation
Hypertension, Essential Parkinson Disease, Late-Onset
Pineal Gland Cancer Protein-Energy Malnutrition
Respiratory Failure Schizophreniform Disorder
Swallowing Disorders Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Obstructive Hydrocephalus:



Diseases related to Obstructive Hydrocephalus

Symptoms & Phenotypes for Obstructive Hydrocephalus

MGI Mouse Phenotypes related to Obstructive Hydrocephalus:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.56 AQP4 CRLF1 GFAP GJB6 NF1 PRL
2 nervous system MP:0003631 9.28 AQP4 CCDC85C CRLF1 GFAP GJB6 NF1

Drugs & Therapeutics for Obstructive Hydrocephalus

Drugs for Obstructive Hydrocephalus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 36)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amphotericin B Approved, Investigational Phase 1, Phase 2 1397-89-3 14956 5280965
2
deoxycholic acid Approved Phase 1, Phase 2 83-44-3 222528
3
Fluconazole Approved, Investigational Phase 1, Phase 2 86386-73-4 3365
4
Miconazole Approved, Investigational, Vet_approved Phase 1, Phase 2 22916-47-8 4189
5 Amphotericin B, deoxycholate drug combination Phase 1, Phase 2
6 Anti-Bacterial Agents Phase 1, Phase 2
7 Antifungal Agents Phase 1, Phase 2
8 Anti-Infective Agents Phase 1, Phase 2
9 Antiparasitic Agents Phase 1, Phase 2
10 Antiprotozoal Agents Phase 1, Phase 2
11 Cytochrome P-450 CYP2C9 Inhibitors Phase 1, Phase 2
12 Cytochrome P-450 Enzyme Inhibitors Phase 1, Phase 2
13 Hormone Antagonists Phase 1, Phase 2
14 Hormones Phase 1, Phase 2
15 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 1, Phase 2
16 Liposomal amphotericin B Phase 1, Phase 2
17 Steroid Synthesis Inhibitors Phase 1, Phase 2
18
Cisplatin Approved Not Applicable 15663-27-1 84093 441203 2767
19
Cyclophosphamide Approved, Investigational Not Applicable 50-18-0, 6055-19-2 2907
20
Etoposide Approved Not Applicable 33419-42-0 36462
21
Magnesium Sulfate Approved, Investigational, Vet_approved Not Applicable 7487-88-9 24083
22
Mannitol Approved, Investigational Not Applicable 69-65-8 453 6251
23
Mesna Approved, Investigational Not Applicable 3375-50-6 598
24
Vincristine Approved, Investigational Not Applicable 2068-78-2, 57-22-7 5978
25
Vitamin A Approved, Nutraceutical, Vet_approved Not Applicable 11103-57-4, 68-26-8 445354
26 Mafosfamide Investigational Not Applicable 88859-04-5
27 Anesthetics Not Applicable
28 Tissue Plasminogen Activator Not Applicable
29 Adjuvants, Immunologic Not Applicable
30 Alkylating Agents Not Applicable
31 Antineoplastic Agents, Alkylating Not Applicable
32 Antirheumatic Agents Not Applicable
33 Etoposide phosphate Not Applicable
34 Immunosuppressive Agents Not Applicable
35 Retinol palmitate Not Applicable
36 retinol Nutraceutical Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effect of Intrathoracic Pressure Regulation on Traumatic Brain Injury Terminated NCT01824589 Phase 4
2 A Randomised Controlled Trial of Lumbar Drainage to Treat Communicating Hydrocephalus After Severe Intraventricular Hemorrhage Completed NCT01041950 Phase 2, Phase 3
3 High-Dose Fluconazole for the Treatment of Cryptococcal Meningitis in HIV-Infected Individuals Completed NCT00885703 Phase 1, Phase 2 Fluconazole;Amphotericin B
4 Prospective Randomized, Controlled Trial for Treatment of Intraventricular Hemorrhage Unknown status NCT01064011 Not Applicable
5 Third Ventriculostomy Versus Shunt for Children With Hydrocephalus Completed NCT01801267 Not Applicable
6 Study of Systemic and Spinal Chemotherapy Followed by Radiation for Infants With Brain Tumors Completed NCT00042367 Not Applicable Induction therapy (Regimen 1, Course 1, Cycle A1;Regimen 1, Course 1, Cycle A2 (Days 22 - 42);Cycle B;Regimen 1, Course 2;Intrathecal Mafosfamide;Regimen 1 Course 2, IT mafosfamide;Regimen 2, Course 1;Regimen 2, Course, 1, Cycle C1;Regimen 2, Course 2
7 Hypothalamic-pituitary Effects After Endoscopic Third Ventriculostomy Terminated NCT01675037

Search NIH Clinical Center for Obstructive Hydrocephalus

Genetic Tests for Obstructive Hydrocephalus

Anatomical Context for Obstructive Hydrocephalus

MalaCards organs/tissues related to Obstructive Hydrocephalus:

41
Brain, Pituitary, Bone, Pineal, Hypothalamus, Lung, Cortex

Publications for Obstructive Hydrocephalus

Articles related to Obstructive Hydrocephalus:

(show top 50) (show all 363)
# Title Authors Year
1
Intraventricular haemorrhage and obstructive hydrocephalus in a term neonate: an uncommon presentation of haemophilia B. ( 29848541 )
2018
2
A case of a mobile choroid plexus cyst presenting with different types of obstructive hydrocephalus. ( 29541488 )
2018
3
Management of Obstructive Hydrocephalus in Pregnant Patient. ( 29492141 )
2018
4
Obstructive hydrocephalus and facial nerve palsy secondary to vertebrobasilar dolichoectasia: Case Report. ( 29629227 )
2018
5
Posterior fossa metastasis-associated obstructive hydrocephalus in adult patients: literature review and practical considerations from the Neuro-Oncology Club of the French Society of Neurosurgery. ( 29935321 )
2018
6
Corrigendum: Dusp16 Deficiency Causes Congenital Obstructive Hydrocephalus and Brain Overgrowth by Expansion of the Neural Progenitor Pool. ( 29417959 )
2018
7
Obstructive hydrocephalus secondary to odontoid pannus: case report and review of literature. ( 29644037 )
2018
8
Amenorrhoea and reversible infertility due to obstructive hydrocephalus: literature review and case report. ( 29430977 )
2018
9
Phase-contrast and three-dimensional driven equilibrium (3D-DRIVE) sequences in the assessment of paediatric obstructive hydrocephalus. ( 29850941 )
2018
10
Obstructive hydrocephalus caused by colloid cyst presenting as a schizophrenia-like psychosis. ( 29884711 )
2018
11
Obstructive Hydrocephalus in Newborn Due to Cerebral Atrium Diverticulum Formation: Complete Resolution After Subdural Hematoma Evacuation. ( 29751185 )
2018
12
Iatrogenic obstructive hydrocephalus resulting from Gelfoam accumulation within the cerebral aqueduct: a case report. ( 29946809 )
2018
13
Influenza A(H5N1) Virus Infection in a Child With Encephalitis Complicated by Obstructive Hydrocephalus. ( 29020163 )
2018
14
Acute Obstructive Hydrocephalus due to a Giant Posterior Cerebral Artery Aneurysm in a Pediatric Patient. ( 29719303 )
2018
15
Unusual location of developmental venous anomaly within fourth ventricle causing obstructive hydrocephalus - A case report. ( 29248318 )
2018
16
Ventriculostomy and Risk of Upward Herniation in Patients with Obstructive Hydrocephalus from Posterior Fossa Mass Lesions. ( 29305758 )
2018
17
Case Report of an Obstructive Hydrocephalus Caused by an Unruptured Mesencephalic Arteriovenous Malformation in a Boy and a Review of Literature. ( 29541280 )
2018
18
Non-obstructive hydrocephalus in a giant hemorrhagic prolactinoma. ( 29480687 )
2018
19
Posterior reversible encephalopathy syndrome (PRES) with obstructive hydrocephalus. ( 28408184 )
2017
20
Parkinsonism after chronic subdural haematoma followed by ventriculoperitoneal shunt for obstructive hydrocephalus: a case report. ( 28658987 )
2017
21
Subclinical meningoventriculitis as a cause of obstructive hydrocephalus. ( 29025781 )
2017
22
Management of quadrigeminal arachnoid cyst associated with obstructive hydrocephalus: report on stereotactic ventricular - cystic stenting. ( 28643523 )
2017
23
Obstructive Hydrocephalus due to Intracerebral Alveolar Echinococcosis. ( 29228350 )
2017
24
Obstructive Hydrocephalus Secondary to Enlarged Virchow-Robin Spaces: A Rare Cause of Pulsatile Tinnitus. ( 28268131 )
2017
25
Obstructive Hydrocephalus in Pyridoxine-Dependent Epilepsy: An Uncommon Complication. ( 28216032 )
2017
26
Dusp16 Deficiency Causes Congenital Obstructive Hydrocephalus and Brain Overgrowth by Expansion of the Neural Progenitor Pool. ( 29170629 )
2017
27
Lateral Ventricle to Sylvian Fissure Shunt for Obstructive Hydrocephalus: First Report. ( 28427106 )
2017
28
A case of acute acquired obstructive hydrocephalus in a cat with suspected ischaemic cerebellar infarct. ( 28491457 )
2017
29
Cerebellar ataxia and obstructive hydrocephalus, rare neurologic presentations in patients with systemic lupus erythematosus. ( 28707035 )
2017
30
Multiple supratentorial subependymomas causing obstructive hydrocephalus. ( 28578305 )
2017
31
Ventricular pseudodiverticula from intraparenchymal cerebrospinal fluid dissection secondary to high-grade obstructive hydrocephalus in children: magnetic resonance imaging findings. ( 28644065 )
2017
32
Emergent presentation of Langerhans cell histiocytosis in a pediatric patient: Acute cerebellar involvement causing obstructive hydrocephalus requiring posterior fossa decompression. ( 29379238 )
2017
33
Everolimus Alleviates Obstructive Hydrocephalus due to Subependymal Giant Cell Astrocytomas. ( 28162859 )
2017
34
Cryptococcal meningitis causing obstructive hydrocephalus in a patient on fingolimod. ( 28687690 )
2017
35
A new shunt for obstructive hydrocephalus: ventricle-Sylvian fissure shunt A preliminary report. ( 28264582 )
2017
36
Complicated acute cerebellitis with obstructive hydrocephalus and tonsillar herniation in a child. ( 28446490 )
2017
37
Cysticerci located in the fourth ventricle causing obstructive hydrocephalus: a radiological emergency requiring prompt diagnosis. ( 27192602 )
2016
38
Comparison of 3 and 7 Tesla Magnetic Resonance Imaging of Obstructive Hydrocephalus Caused by Tectal Glioma. ( 27867929 )
2016
39
Acute obstructive hydrocephalus complicating decompression surgery of the craniovertebral junction. ( 27366268 )
2016
40
Obstructive Hydrocephalus Caused by an Unruptured Arteriovenous Malformation Successfully Treated by Endoscopic Third Ventriculostomy After Shunt Dysfunction. ( 28127723 )
2016
41
Transient Obstructive Hydrocephalus in Patients with Intracerebral Hemorrhage: Report of Two Cases ( 29046016 )
2016
42
Spontaneous third ventriculostomy 8A years after diagnosis of obstructive hydrocephalus. ( 27107889 )
2016
43
Case Report: Acute obstructive hydrocephalus associated with infratentorial extra-axial fluid collection following foramen magnum decompression and durotomy for Chiari malformation type I. ( 27303624 )
2016
44
Locked-in syndrome in a patient with acute obstructive hydrocephalus, caused by large unruptured aneurysm of the basilar artery (BA). ( 27633006 )
2016
45
Grossly calcified choroid plexus concealing foramen of Monro meningiomas as an unusual cause of obstructive hydrocephalus. ( 26889294 )
2016
46
Rhombencephalosynapsis: A rare cerebellar malformation associated with aqueductal stenosis and obstructive hydrocephalus. ( 27841240 )
2016
47
Dual-Channel Minimally Invasive Endoscopic Port for Evacuation of Deep-Seated Spontaneous Intracerebral Hemorrhage with Obstructive Hydrocephalus. ( 27132183 )
2016
48
Changes in Rat Brain Tissue Microstructure and Stiffness during the Development of Experimental Obstructive Hydrocephalus. ( 26848844 )
2016
49
Endoscopic third ventriculostomy for obstructive hydrocephalus: Outcome analysis of 120 consecutively treated patients from a developing country. ( 26700200 )
2016
50
Experience with Lumbar Puncture Following Endoscopic Third Ventriculostomy for Obstructive Hydrocephalus. ( 27490647 )
2016

Variations for Obstructive Hydrocephalus

Expression for Obstructive Hydrocephalus

Search GEO for disease gene expression data for Obstructive Hydrocephalus.

Pathways for Obstructive Hydrocephalus

Pathways related to Obstructive Hydrocephalus according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.33 GFAP NF1 SYP

GO Terms for Obstructive Hydrocephalus

Biological processes related to Obstructive Hydrocephalus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell communication GO:0007154 9.16 GJB6 NF1
2 negative regulation of endothelial cell proliferation GO:0001937 8.96 NF1 PRL
3 regulation of long-term neuronal synaptic plasticity GO:0048169 8.62 NF1 SYP

Sources for Obstructive Hydrocephalus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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