MCID: OBS004
MIFTS: 46

Obstructive Hydrocephalus

Categories: Neuronal diseases

Aliases & Classifications for Obstructive Hydrocephalus

MalaCards integrated aliases for Obstructive Hydrocephalus:

Name: Obstructive Hydrocephalus 12 54 15 71 32

Classifications:



External Ids:

Disease Ontology 12 DOID:14159
ICD9CM 34 331.4
MeSH 43 D006849
NCIt 49 C116347
SNOMED-CT 67 230746009
ICD10 32 G91.1
UMLS 71 C0549423

Summaries for Obstructive Hydrocephalus

MalaCards based summary : Obstructive Hydrocephalus is related to cellular ependymoma and subependymal giant cell astrocytoma. An important gene associated with Obstructive Hydrocephalus is FOXJ1 (Forkhead Box J1), and among its related pathways/superpathways are Regulation of lipid metabolism Insulin signaling-generic cascades and Neuroscience. The drugs Pharmaceutical Solutions and Vincristine have been mentioned in the context of this disorder. Affiliated tissues include brain, pineal and pituitary, and related phenotypes are behavior/neurological and growth/size/body region

Related Diseases for Obstructive Hydrocephalus

Diseases related to Obstructive Hydrocephalus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 435)
# Related Disease Score Top Affiliating Genes
1 cellular ependymoma 32.8 SYP OLIG2 FOXJ1
2 subependymal giant cell astrocytoma 31.4 TSC2 TSC1 SYP GFAP ENO2
3 intracranial hypertension 31.3 PRL AQP4 AQP1
4 communicating hydrocephalus 31.0 ZIC3 AQP4 AQP1
5 chiari malformation 30.9 SYP GFAP AQP1
6 head injury 30.5 PRL ENO2
7 neurilemmoma of the fifth cranial nerve 30.4 NF2 CRLF1
8 pineoblastoma 30.3 SYP GFAP AFP
9 pineocytoma 30.1 SYP GFAP ENO2
10 intracranial cysts 30.1 GFAP ENO2
11 brain stem infarction 30.0 PLG PLAT CRLF1
12 arachnoiditis 30.0 RICTOR CRLF1 AQP4
13 hydrocephalus 30.0 ZIC3 SYP PRL PLAT GFAP FOXJ1
14 traumatic brain injury 29.9 GFAP ENO2 AQP4
15 brain edema 29.8 PLAT GFAP AQP4 AQP1
16 syringomyelia 29.7 RICTOR GFAP CRLF1 AQP4
17 juvenile pilocytic astrocytoma 29.7 SYP OLIG2 NF1 GFAP
18 hemangioblastoma 29.6 SYP GFAP ENO2 AQP1
19 spinal meningioma 29.6 NF2 NF1
20 neurilemmoma 29.6 NF2 NF1 GFAP ENO2
21 pineal gland cancer 29.5 SYP GFAP ENO2 AFP
22 acoustic neuroma 29.5 NF2 NF1 CRLF1 AQP4 AQP1
23 central neurocytoma 29.4 SYP OLIG2 GFAP ENO2
24 tuberous sclerosis 1 29.3 TSC2 TSC1 RICTOR
25 gastrointestinal stromal tumor 29.1 SYP NF2 NF1 ENO2
26 cerebral degeneration 29.0 ZIC3 SYP OLIG2 GFAP FOXJ1 AQP4
27 glioblastoma multiforme 28.4 TSC2 TSC1 SYP NF2 NF1 GFAP
28 meningioma, familial 28.2 SYP RICTOR PRL NF2 NF1 GFAP
29 benign ependymoma 28.2 TSC2 TSC1 SYP NF2 NF1 GFAP
30 medulloblastoma 27.9 TSC2 SYP RICTOR NF1 GFAP ENO2
31 tuberous sclerosis 27.6 TSC2 TSC1 SYP RICTOR NF2 NF1
32 hydrocephalus, congenital, 1 11.7
33 hydrocephalus due to congenital stenosis of aqueduct of sylvius 11.6
34 congenital hydrocephalus 11.5
35 ciliary dyskinesia, primary, 43 11.4
36 congenital communicating hydrocephalus 11.4
37 megalencephaly-capillary malformation-polymicrogyria syndrome 11.2
38 extraventricular neurocytoma 10.5 SYP GFAP
39 desmoplastic infantile ganglioglioma 10.5 SYP GFAP
40 dysferlinopathy 10.5 AQP4 AQP1
41 lung combined type small cell carcinoma 10.5 SYP GFAP
42 angiocentric glioma 10.5 SYP GFAP
43 non-gestational ovarian choriocarcinoma 10.5 PRL AFP
44 thymus sarcomatoid carcinoma 10.4 SYP AFP
45 rectum neuroendocrine neoplasm 10.4 SYP AFP
46 abducens nerve disease 10.4 PRL AQP4
47 medullomyoblastoma 10.4 SYP GFAP
48 hematocele of tunica vaginalis testis 10.4 CRLF1 AFP
49 papillary thymic adenocarcinoma 10.4 SYP AFP
50 urachal adenocarcinoma 10.4 NF1 AFP

Comorbidity relations with Obstructive Hydrocephalus via Phenotypic Disease Network (PDN): (show all 18)


Acute Cystitis Alzheimer Disease
Brain Cancer Brain Compression
Cerebellum Cancer Cerebral Degeneration
Communicating Hydrocephalus Decubitus Ulcer
Deficiency Anemia Epilepsy, Focal, with Speech Disorder and with or Without Mental Retardation
Hypertension, Essential Parkinson Disease, Late-Onset
Pineal Gland Cancer Protein-Energy Malnutrition
Respiratory Failure Schizophreniform Disorder
Swallowing Disorders Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Obstructive Hydrocephalus:



Diseases related to Obstructive Hydrocephalus

Symptoms & Phenotypes for Obstructive Hydrocephalus

MGI Mouse Phenotypes related to Obstructive Hydrocephalus:

45 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.44 AFP AQP1 AQP4 CRLF1 ENO2 FOXJ1
2 growth/size/body region MP:0005378 10.32 AQP1 AQP4 ENO2 FOXJ1 GFAP NF1
3 mortality/aging MP:0010768 10.31 AFP AQP1 AQP4 CCDC85C CRLF1 FOXJ1
4 cardiovascular system MP:0005385 10.3 AQP1 AQP4 CCDC85C FOXJ1 GFAP NF1
5 cellular MP:0005384 10.25 ENO2 FOXJ1 GFAP NF1 OLIG2 PLAT
6 nervous system MP:0003631 10.25 AQP1 AQP4 CCDC85C CRLF1 ENO2 FOXJ1
7 endocrine/exocrine gland MP:0005379 10.24 AFP AQP1 AQP4 NF1 NF2 PLAT
8 liver/biliary system MP:0005370 10.09 AFP NF1 NF2 PLG PRL RICTOR
9 neoplasm MP:0002006 10.02 AFP NF1 NF2 OLIG2 PLG PRL
10 hearing/vestibular/ear MP:0005377 9.93 AQP1 AQP4 NF1 NF2 PLAT ZIC3
11 reproductive system MP:0005389 9.93 AFP AQP1 FOXJ1 NF1 NF2 PLAT
12 renal/urinary system MP:0005367 9.86 AQP1 AQP4 NF1 NF2 PLG RICTOR
13 respiratory system MP:0005388 9.7 AQP1 AQP4 ENO2 FOXJ1 NF1 NF2
14 vision/eye MP:0005391 9.32 AQP1 AQP4 GFAP NF1 NF2 OLIG2

Drugs & Therapeutics for Obstructive Hydrocephalus

Drugs for Obstructive Hydrocephalus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Pharmaceutical Solutions Phase 1, Phase 2
2
Vincristine Approved, Investigational 57-22-7, 2068-78-2 5978
3
Mesna Approved, Investigational 3375-50-6 598
4
Etoposide Approved 33419-42-0 36462
5
Cisplatin Approved 15663-27-1 2767 441203 84093
6
Mannitol Approved, Investigational 69-65-8 6251 453
7
Cyclophosphamide Approved, Investigational 50-18-0, 6055-19-2 2907
8
Magnesium Sulfate Approved, Investigational, Vet_approved 7487-88-9 24083
9
Vitamin A Approved, Nutraceutical, Vet_approved 22737-96-8, 68-26-8, 11103-57-4 9904001 445354
10 Mafosfamide Investigational 88859-04-5
11 Anesthetics
12 Tissue Plasminogen Activator
13 Immunologic Factors
14 retinol
15 Retinol palmitate
16 Adjuvants, Immunologic
17 Etoposide phosphate
18 Alkylating Agents
19 Immunosuppressive Agents
20 Antirheumatic Agents

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 Effects of Intrathoracic Pressure Regulation Therapy in Patients With Elevated Intracranial Pressure Due to Brain Injury or Intracranial Pathology Terminated NCT01824589 Phase 4
2 Lumbar Drainage for Communicating Hydrocephalus After Intraventricular Hemorrhage: a Randomised, Controlled Trial(LUCAS-IVH: LUmbar CAtheter for Severe IntraVentricular Hemorrhage) Completed NCT01041950 Phase 2, Phase 3
3 Voices of Patients' Relatives to Support Weaning From Mechanical Ventilation in Patients With Severe Brain Injury - VOICE-WEANING, a Randomized Clinical Trial Recruiting NCT03795623 Phase 2, Phase 3
4 A Placebo-Controlled, Observer-Blinded, Crossover Study to Evaluate the Safety and Effectiveness of a Single, Autologous, Cord Blood Stem Cell Infusion for the Treatment of Cerebral Palsy in Children Terminated NCT01072370 Phase 1, Phase 2
5 A Prospective Randomized, Controlled Trial for Treatment of Intraventricular Hemorrhage: External Ventricular Drainage and Intraventricular Thrombolysis vs. External Ventricular Drainage and Endoscopic Evacuation Unknown status NCT01064011
6 A Randomized Controlled Trial of Endoscopic Third Ventriculostomy Versus Ventricular Shunt for Children With Communicating Hydrocephalus Completed NCT01801267
7 Pilot Study of Systemic and Intrathecal Chemotherapy Followed by Conformal Radiation for Infants With Brain Tumors Completed NCT00042367 Induction therapy (Regimen 1, Course 1, Cycle A1;Regimen 1, Course 1, Cycle A2 (Days 22 - 42);Cycle B;Regimen 1, Course 2;Intrathecal Mafosfamide;Regimen 1 Course 2, IT mafosfamide;Regimen 2, Course 1;Regimen 2, Course, 1, Cycle C1;Regimen 2, Course 2
8 Endoscopic Third Ventriculostomy Versus Ventriculo-peritoneal Shunting in Idiopathic Normal Pressure Hydrocephalus Recruiting NCT03245138
9 Assessment of Cerebrospinal Fluid Flow Related Disorders Using a Phase-contrast Magnetic Resonance Imaging Technique. Recruiting NCT03656016
10 Multimodal Sonographic Monitoring of Cerebral Perfusion, Ventricle Seize and Optic Nerve Diameter During Weaning of Cerebrospinal Fluid Drainage Catheters: a Single Centre Observational Trial Recruiting NCT02408757
11 Lumbar Drainage Compared With Extraventricular Drainage of Cerebral Spinal Fluid in Treatment of Patients With Subarachnoid Hemorrhage - a Prospective Randomized Controlled Trial Recruiting NCT03065231
12 Evaluating Raised Intracranial Pressure Using MR Elastography Active, not recruiting NCT03096743
13 Endoscopic Intraventricular Hematoma Evacuation Surgery Versus External Ventricular Drainage for the Treatment of Patients With Moderate to Severe Intraventricular Hemorrhage: a Multicenter, Randomized, Controlled Trial Not yet recruiting NCT04037267
14 Hypothalamic-pituitary Effects After Endoscopic Third Ventriculostomy Terminated NCT01675037

Search NIH Clinical Center for Obstructive Hydrocephalus

Genetic Tests for Obstructive Hydrocephalus

Anatomical Context for Obstructive Hydrocephalus

MalaCards organs/tissues related to Obstructive Hydrocephalus:

40
Brain, Pineal, Pituitary, Bone, Cerebellum, Spinal Cord, B Cells

Publications for Obstructive Hydrocephalus

Articles related to Obstructive Hydrocephalus:

(show top 50) (show all 1966)
# Title Authors PMID Year
1
Visual loss in tuberous sclerosis. 61 54
1745348 1991
2
A case of developing obstructive hydrocephalus following aqueductal stenosis caused by developmental venous anomalies. 61
31907600 2020
3
Spontaneous Third Ventriculostomy in Krabbe Disease. 61
32197817 2020
4
Aqueductal Compression by Dilated Virchow-Robin Spaces in the Mesencephalic-Pontine Region Presenting with Symptoms Mimicking Normal Pressure Hydrocephalus: A Case Report and Review of Literature. 61
32200017 2020
5
Obstructive hydrocephalus due to aqueductal stenosis from developmental venous anomaly draining bilateral medial thalami: a case report. 61
32300468 2020
6
Pre-operative headaches and obstructive hydrocephalus predict an extended length of stay following suboccipital decompression for pediatric Chiari I malformation. 61
32519127 2020
7
Risk Factors Portending Extended Length of Stay After Suboccipital Decompression for Adult Chiari I Malformation. 61
32147550 2020
8
Biventricular hydrocephalus secondary to aqueductal developmental venous anomaly. 61
32295747 2020
9
Endoscopic Third Ventriculostomy in an Untreated Vein of Galen Malformation Presenting Lately with Acute Obstructive Hydrocephalus. 61
32113993 2020
10
Flying with Colloid Cyst: A Cautionary Note. 61
32001391 2020
11
Central neurocytoma originating in third ventricle with expansion into the cerebral aqueduct and fourth ventricle: Case report and review of literature. 61
32502563 2020
12
Three-Dimensional Versus Two-Dimensional Endoscopic Third Ventriculostomy: Surgical Results Of A Preliminary Comparative Study. 61
32497846 2020
13
Delayed extensive brain edema caused by the growth of a giant basilar apex aneurysm treated with basilar artery obliteration: a case report. 61
32505180 2020
14
Excision of a Retrochiasmatic Craniopharyngioma by Transcallosal, Interforniceal Approach With Exoscope Assistance: 2-Dimensional Operative Video. 61
32497205 2020
15
Palliative ventriculoperitoneal shunting in dogs with obstructive hydrocephalus caused by tumors affecting the third ventricle. 61
32472726 2020
16
The effect of mTOR inhibition on obstructive hydrocephalus in patients with tuberous sclerosis complex (TSC) related subependymal giant cell astrocytoma (SEGA). 61
32285309 2020
17
"Two-Birds-One-Stone" Approach for Treating an Infant with Chiari I Malformation and Hydrocephalus: Is Cerebrospinal Fluid Diversion as Sole Treatment Enough? 61
32028005 2020
18
Too Much on Your "Plate"? Spectrum of Pathologies Involving the Tectal Plate. 61
32063011 2020
19
Spontaneous change in Density of colloid cyst - an unusual phenomenon. 61
32461180 2020
20
Acute Cerebellitis or Postinfectious Cerebellar Ataxia? Clinical and Imaging Features in Acute Cerebellitis. 61
32160830 2020
21
An aggressive extension of dumbbell-type pediatric skull base meningioma: a case report with a review of literature. 61
32371076 2020
22
Frame-Based Stereotactic Endoscopic Third Ventriculostomy-Toward Improved Precision and Minimizing Morbidities. 61
32437981 2020
23
Trochlear Schwannoma Arising from Transition Zone of Nerve Sheath in the Pineal Region: Case Report and Review of the Literature. 61
32059963 2020
24
Myxoid glioneuronal tumor, PDGFRA p.K385-mutant: clinical, radiologic, and histopathologic features. 61
31609499 2020
25
Hemorrhagic colloid cyst of the third ventricle: A rare cause of colloid cyst growth and progressive hydrocephalus. Case report. 61
32430243 2020
26
Iodine-123-Iomazenil SPECT Revealed Recovery of Neuronal Viability in Association with Improvement in Symptoms Following Treatment for Obstructive Hydrocephalus due to a Giant Posterior Cerebral Artery Aneurysm. 61
32084622 2020
27
Acute cerebellar edema after traumatic brain injury in a child. a case report. 61
31758241 2020
28
Clinical Outcomes in Patients with Renal Cell Carcinoma Metastases to the Choroid Plexus. 61
32251814 2020
29
High Prevalence of Developmental Venous Anomaly in Diffuse Intrinsic Pontine Gliomas: A Pediatric Control Study. 61
31342064 2020
30
Anaesthetic management of intracranial hypertension and pregnancy. A case report. 61
32192721 2020
31
Design and validation of a 3D-printed simulator for endoscopic third ventriculostomy. 61
31712902 2020
32
Obstructive Hydrocephalus in the Differential Diagnosis of Early Adolescent Depression. 61
32125901 2020
33
ETV in infancy and childhood below 2 years of age for treatment of hydrocephalus. 61
32222800 2020
34
A primary third ventricle mixed germ cell tumor with leptomeningeal dissemination of immature teratoma component. 61
31418081 2020
35
Postoperative Tetraplegia to a Child after Cerebellar Pilocytic Astrocytoma Excision at Prone Position: Case Report and Literature Review. 61
32161253 2020
36
[Analysis of misdiagnosis causes of suprasellar arachnoid cysts]. 61
32164116 2020
37
A rare case of intralesional haemorrhage of a benign aqueductal cyst after CSF diversion treatment. A case report and review of literature. 61
32202165 2020
38
Neocortical tissue recovery in severe congenital obstructive hydrocephalus after intraventricular administration of bone marrow-derived mesenchymal stem cells. 61
32183876 2020
39
Provider views on perioperative steroid use for patients with newly diagnosed pediatric brain tumors. 61
32026434 2020
40
Endoscopic-assisted surgery versus microsurgery for pineal region tumors: a single-center retrospective study. 61
32198566 2020
41
Overshunting-Associated Myelopathy Treated with Endoscopic Third Ventriculostomy. 61
31704357 2020
42
Obstruction of Ventriculoperitoneal Shunt After Myelography-Report of a Unique Case and Its Treatment. 61
31756508 2020
43
Second Window Indocyanine Green (SWIG) Near Infrared Fluorescent Transventricular Biopsy of Pineal Tumor. 61
31669685 2020
44
Letter to the Editor Regarding "Surgical Techniques and Long-term Outcomes of Flexible Neuroendoscopic Aqueductoplasty and Stenting in Infants with Obstructive Hydrocephalus: A Single-center Study". 61
32059271 2020
45
Post-shunting corpus callosal signal change and review of the literature. 61
31874812 2020
46
Ruptured Tentorial Arteriovenous Fistula: Endoscopic-Assisted Microsurgical Disconnection Using Indocyanine Green Videoangiography Guidance. 61
31726094 2020
47
Occipitocervical fusion complicated with cerebellar abscess: a case report. 61
32111221 2020
48
Unexpected phenotype in a frameshift mutation of PTCH1. 61
31578813 2020
49
Magnetic Resonance Imaging Findings in 13 Neurologic Pot-Bellied Pigs. 61
32076601 2020
50
ETV for successful treatment of holocord syrinx with hydrocephalus: a case report. 61
31994420 2020

Variations for Obstructive Hydrocephalus

Expression for Obstructive Hydrocephalus

Search GEO for disease gene expression data for Obstructive Hydrocephalus.

Pathways for Obstructive Hydrocephalus

Pathways related to Obstructive Hydrocephalus according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.21 TSC2 TSC1 PLG PLAT NF2 CRLF1
2 12.09 SYP NF2 NF1 GFAP ENO2
3 11.4 SYP OLIG2 GFAP
4 11.21 TSC2 TSC1 RICTOR
5 10.97 TSC2 TSC1 NF2 NF1
6 10.48 PLG PLAT

GO Terms for Obstructive Hydrocephalus

Cellular components related to Obstructive Hydrocephalus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 apical part of cell GO:0045177 9.43 PLAT NF2 AQP1
2 Schaffer collateral - CA1 synapse GO:0098685 9.33 SYP PLG PLAT
3 astrocyte end-foot GO:0097450 8.96 GFAP AQP4
4 TSC1-TSC2 complex GO:0033596 8.62 TSC2 TSC1

Biological processes related to Obstructive Hydrocephalus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.55 TSC2 TSC1 PLG NF2 NF1
2 negative regulation of protein kinase activity GO:0006469 9.54 TSC2 NF2 NF1
3 cerebral cortex development GO:0021987 9.5 TSC1 NF1 CCDC85C
4 regulation of cell-matrix adhesion GO:0001952 9.4 TSC1 NF1
5 multicellular organismal water homeostasis GO:0050891 9.26 AQP4 AQP1
6 cellular water homeostasis GO:0009992 8.96 AQP4 AQP1
7 trans-synaptic signaling by BDNF, modulating synaptic transmission GO:0099183 8.62 PLG PLAT

Molecular functions related to Obstructive Hydrocephalus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 water channel activity GO:0015250 8.62 AQP4 AQP1

Sources for Obstructive Hydrocephalus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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