MCID: OBS004
MIFTS: 43

Obstructive Hydrocephalus

Categories: Neuronal diseases
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Aliases & Classifications for Obstructive Hydrocephalus

MalaCards integrated aliases for Obstructive Hydrocephalus:

Name: Obstructive Hydrocephalus 11 53 14 71 31

Classifications:



External Ids:

Disease Ontology 11 DOID:14159
ICD9CM 34 331.4
MeSH 43 D006849
NCIt 49 C116347
SNOMED-CT 68 230746009
ICD10 31 G91.1
UMLS 71 C0549423

Summaries for Obstructive Hydrocephalus

MalaCards based summary: Obstructive Hydrocephalus is related to cellular ependymoma and diffuse midline glioma, h3 k27m-mutant. An important gene associated with Obstructive Hydrocephalus is FOXJ1 (Forkhead Box J1), and among its related pathways/superpathways are Signal Transduction and Neuroscience. Affiliated tissues include pineal, pituitary and brain, and related phenotypes are nervous system and growth/size/body region

Related Diseases for Obstructive Hydrocephalus

Diseases related to Obstructive Hydrocephalus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 548)
# Related Disease Score Top Affiliating Genes
1 cellular ependymoma 31.8 SYP NF2 GFAP
2 diffuse midline glioma, h3 k27m-mutant 31.7 OLIG2 H3-3B H3-3A
3 hydrocephalus 31.1 SYP PLAT GFAP FOXJ1 ENO2 CCDC85C
4 chiari malformation 30.8 SYP GFAP AQP1
5 arteriovenous malformation 30.5 PLG PLAT NF1
6 tuberous sclerosis 1 30.4 TSC2 TSC1
7 arachnoiditis 30.4 GFAP AQP4
8 intracranial hypertension 30.4 PLG GFAP ENO2 AQP4 AQP1
9 syringomyelia 30.4 NF1 GFAP AQP4
10 hemangioblastoma 30.2 SYP GFAP ENO2
11 neurilemmoma of the fifth cranial nerve 30.2 NF2 NF1
12 pineocytoma 30.1 SYP GFAP ENO2
13 brain stem infarction 30.1 PLG PLAT
14 brain edema 30.0 GFAP AQP4 AQP1
15 meningocele 30.0 SHH NF1 AFP
16 benign teratoma 30.0 SYP ENO2 AFP
17 optic nerve disease 30.0 NF1 GFAP AQP4 AQP1
18 malignant teratoma 29.9 SYP GFAP ENO2 AFP
19 von hippel-lindau syndrome 29.8 TSC2 SYP NF1 ENO2
20 neurilemmoma 29.8 SYP NF2 NF1 GFAP ENO2
21 hemiplegia 29.7 PLG PLAT ENO2
22 central neurocytoma 29.7 SYP OLIG2 KIAA1549 GFAP ENO2
23 neural tube defects 29.7 SYP SHH NF1 GFAP ENO2 AFP
24 teratoma 29.6 SYP SHH GFAP ENO2 AFP
25 pineoblastoma 29.6 SYP SHH OLIG2 GFAP ENO2
26 hemangioma 29.6 TSC2 TSC1 SYP SHH ENO2
27 cowden syndrome 29.6 TSC2 TSC1 NF2 NF1
28 subependymal giant cell astrocytoma 29.6 TSC2 TSC1 SYP NF1 KIAA1549 GFAP
29 gastrointestinal stromal tumor 29.5 SYP NF2 NF1 ENO2
30 pineal gland cancer 29.5 SYP SHH OLIG2 GFAP ENO2 AFP
31 medulloblastoma 29.5 TSC2 SYP SHH OLIG2 NF1 GFAP
32 tuberous sclerosis 29.4 TSC2 TSC1 SYP NF2 NF1 GFAP
33 stroke, ischemic 29.4 PLG PLAT GFAP ENO2 AQP4
34 cerebral degeneration 29.3 SYP SHH OLIG2 NF1 GFAP FOXJ1
35 meningioma, familial 29.0 TSC1 SYP SHH OLIG2 NF2 NF1
36 pilocytic astrocytoma 29.0 TSC1 SYP OLIG2 NF1 KIAA1549 H3-3B
37 low grade glioma 28.8 TSC2 TSC1 SYP OLIG2 NF1 KIAA1549
38 spinal cancer 28.6 OLIG2 NF2 NF1 KIAA1549 H3-3B H3-3A
39 atypical teratoid rhabdoid tumor 28.4 SYP SHH OLIG2 NF2 NF1 KIAA1549
40 brain cancer 28.2 TSC1 SYP SHH PLG OLIG2 NF2
41 spinal cord disease 28.1 TSC2 TSC1 SYP OLIG2 NF2 NF1
42 hydrocephalus, congenital, 1 11.2
43 odontochondrodysplasia 1 11.2
44 ciliary dyskinesia, primary, 43 11.2
45 hydrocephalus due to congenital stenosis of aqueduct of sylvius 11.2
46 congenital communicating hydrocephalus 11.2
47 congenital hydrocephalus 11.1
48 chiari malformation type ii 11.1
49 papillary tumor of the pineal region 11.1
50 pineal parenchymal tumor of intermediate differentiation 11.1

Comorbidity relations with Obstructive Hydrocephalus via Phenotypic Disease Network (PDN): (show all 18)


Acute Cystitis Alzheimer Disease, Familial, 1
Brain Cancer Brain Compression
Cerebellum Cancer Cerebral Degeneration
Communicating Hydrocephalus Decubitus Ulcer
Deficiency Anemia Epilepsy, Focal, with Speech Disorder and with or Without Impaired Intellectual Development
Hypertension, Essential Parkinson Disease, Late-Onset
Pineal Gland Cancer Protein-Energy Malnutrition
Respiratory Failure Schizophreniform Disorder
Swallowing Disorders Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Obstructive Hydrocephalus:



Diseases related to Obstructive Hydrocephalus

Symptoms & Phenotypes for Obstructive Hydrocephalus

MGI Mouse Phenotypes related to Obstructive Hydrocephalus:

45 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 10.43 AQP1 AQP4 CCDC85C DUSP16 ENO2 FOXJ1
2 growth/size/body region MP:0005378 10.38 AQP1 AQP4 DUSP16 ENO2 FOXJ1 GFAP
3 homeostasis/metabolism MP:0005376 10.37 AFP AQP1 AQP4 DUSP16 GFAP H3-3A
4 behavior/neurological MP:0005386 10.25 AFP AQP1 AQP4 ENO2 FOXJ1 GFAP
5 renal/urinary system MP:0005367 10.21 AQP1 AQP4 H3-3A H3-3B NF1 NF2
6 cellular MP:0005384 10.18 ENO2 FOXJ1 GFAP H3-3A H3-3B NF1
7 endocrine/exocrine gland MP:0005379 10.16 AFP AQP1 AQP4 NF1 NF2 PLAT
8 cardiovascular system MP:0005385 10.15 AQP1 AQP4 CCDC85C DUSP16 FOXJ1 GFAP
9 neoplasm MP:0002006 10.14 AFP NF1 NF2 OLIG2 PLG SHH
10 digestive/alimentary MP:0005381 10.03 AQP4 FOXJ1 GFAP NF1 NF2 PLAT
11 respiratory system MP:0005388 10 AQP1 AQP4 ENO2 FOXJ1 NF1 NF2
12 reproductive system MP:0005389 10 AFP AQP1 AQP4 DUSP16 FOXJ1 H3-3A
13 vision/eye MP:0005391 9.65 AQP1 AQP4 GFAP NF1 NF2 OLIG2
14 mortality/aging MP:0010768 9.53 AQP1 AQP4 CCDC85C DUSP16 FOXJ1 GFAP

Drugs & Therapeutics for Obstructive Hydrocephalus

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Lumbar Drainage for Communicating Hydrocephalus After Intraventricular Hemorrhage: a Randomised, Controlled Trial(LUCAS-IVH: LUmbar CAtheter for Severe IntraVentricular Hemorrhage) Completed NCT01041950 Phase 2, Phase 3
2 Hypothalamic-pituitary Effects After Endoscopic Third Ventriculostomy Terminated NCT01675037

Search NIH Clinical Center for Obstructive Hydrocephalus

Genetic Tests for Obstructive Hydrocephalus

Anatomical Context for Obstructive Hydrocephalus

Organs/tissues related to Obstructive Hydrocephalus:

MalaCards : Pineal, Pituitary, Brain, Medulla Oblongata, Spinal Cord, Bone Marrow, Cerebellum

Publications for Obstructive Hydrocephalus

Articles related to Obstructive Hydrocephalus:

(show top 50) (show all 2281)
# Title Authors PMID Year
1
Visual loss in tuberous sclerosis. 53 62
1745348 1991
2
Fatal fentanyl-associated cerebellitis in a young man. 62
36192246 2023
3
Pineal anlage tumor: a case report and the literature review. 62
36471063 2022
4
Tumefactive Perivascular Spaces Causing Obstructive Hydrocephalus. 62
36472539 2022
5
Bifocal pineal and suprasellar germinomas with posterior fossa metastases in an adolescent patient. 62
36189158 2022
6
[Pediatric Posterior Fossa Tumors]. 62
36426530 2022
7
Clinical manifestations and outcomes of 20 Korean hypochondroplasia patients with the FGFR3 N540K variant. 62
36442838 2022
8
Comparison of primary and secondary endoscopic third ventriculostomy for patients with obstructive hydrocephalus: A meta-analysis and systematic review. 62
36334995 2022
9
Evaluation of developmental profiles of children with hydrocephalus. 62
36333085 2022
10
Intracranial aneurysms mimicking third ventricular masses: case series and systematic review. 62
36458318 2022
11
Incidental and Clinical Significance of Slit Ventricles in Fixed Pressure Valves. 62
36465732 2022
12
Long-term quality of life after ETV or ETV with consecutive VP shunt placement in hydrocephalic pediatric patients. 62
35790573 2022
13
Isolated pediatric retroclival epidural hematoma following a minor blunt head trauma: a case report with review of the literature. 62
36195676 2022
14
Clinical Comparison of FD-CT and MS-CT in Aneurysmal Subarachnoid Haemorrhage: A Single Center Experience. 62
36292131 2022
15
Percutaneous construction of ventriculo-atrial (VA) shunt - Case report. 62
36113370 2022
16
On Natural History and Management of Colloid Cysts: Time to Rethink? 62
36323347 2022
17
3-Dimensional Exoscope for Far Lateral Approach to Pontomedullary Cavernous Malformation. 62
35953042 2022
18
Adult Primary Pineal Alveolar Rhabdomyosarcoma with FOXO1 Gene Rearrangement and OLIG2 Expression: A Rare Case Report and Literature Review. 62
35188829 2022
19
Factors Associated with Acute Obstructive Hydrocephalus After Retrosigmoid Approach for Extra-Axial Cerebellopontine Angle Tumors. 62
35489600 2022
20
Papillary Tumor of the Pineal Region Rare Pediatric CNS Tumor Case Series Treated in King Fahad Medical City (KFMC). 62
36290872 2022
21
Obstructive hydrocephalus secondary to a perianeurysmal cyst: a case report. 62
30688108 2022
22
A hidden infection: Racemose neurocysticercosis causing hydrocephalus; a case report. 62
35987027 2022
23
Pineal germinoma in a young adult: A case report. 62
35347869 2022
24
External ventricular drain placement is associated with lower mortality after intracerebral hemorrhage with intraventricular hemorrhage. 62
36109697 2022
25
Characteristics and Long-Term Outcome of Cerebellar Strokes in a Single Health Care Facility in Mexico. 62
36259000 2022
26
Endoscopic biopsy of pineal tumors: two burr hole trans-foramen of Monro approach and endonasal trans-tuber cinereum approach. 62
36112201 2022
27
Complications Associated With Ventriculoperitoneal Shunt Surgery for Normal Pressure Hydrocephalus Using Stereotactic Navigation and Abdominal Laparoscopy: A Single-Institution Case Series. 62
35972080 2022
28
Racemose Fourth Ventricle Neurocysticercosis Excision Through Telovelar Approach and Hydrodissection. 62
35717015 2022
29
Tectal Plate Gliomas Masquerading as Idiopathic Aqueduct Stenosis. 62
35752420 2022
30
Arterial Spin-Labeling Perfusion Metrics in Pediatric Posterior Fossa Tumor Surgery. 62
36137658 2022
31
Upfront Radiosurgery for Treatment of Symptomatic Obstructive Hydrocephalus due to Brain Tumors. 62
36258982 2022
32
[Ocular symptoms in cerebellitis caused by COVID-19 : Cerebellitis, a less noticed disease with neuro-ophthalmological findings]. 62
36169716 2022
33
Giant Colloid Cyst. 62
35803569 2022
34
[A somnolent man]. 62
36036692 2022
35
Transcortical Endoscopic Removal of Residual Craniopharyngioma in the Third Ventricle: Surgical Video. 62
35568124 2022
36
Giant occipital encephalocele complicated with obstructive hydrocephalus: A case report. 62
35855875 2022
37
Concurrent cardiac and central nervous system complications of acute infective endocarditis: case report. 62
36004042 2022
38
Late Manifestation of Subependymal Giant Cell Astrocytoma With Hydrocephalus in an Adult Patient With Tuberous Sclerosis Complex. 62
36176856 2022
39
De novo brain AVM following radiotherapy for cerebral cavernous malformation in a child: A 15-year clinical course. 62
35100907 2022
40
Intra-Parenchymal Cerebellar Metastasis-A Rare Presentation of Castration-Resistant Prostate Cancer. 62
35946005 2022
41
Outcomes of Endoscopic Third Ventriculostomy in Pediatric Patients With Hydrocephalus. 62
35936164 2022
42
Diagnosis and Surgical Management of Neonatal Hydrocephalus. 62
35868728 2022
43
Ruptured Intracranial Dermoid Cyst - Unusual Cause of Obstructive Hydrocephalus. 62
36076702 2022
44
Cerebellar primary central nervous system lymphoma: Case series report. 62
35901552 2022
45
Diagnosis and Treatment of Pineal Region Tumors in Adults: A EURACAN Overview. 62
35954310 2022
46
Neuroimaging Findings in CHANTER Syndrome: A Case Series. 62
35798385 2022
47
Late-onset obstructive hydrocephalus associated with occipital encephalocele with large skull defect successfully treated by endoscopic third ventriculostomy. 62
35904586 2022
48
Comments on "Neonatal infratentorial subdural hematoma contributing to obstructive hydrocephalus in the setting of therapeutic cooling: A case report". 62
35978975 2022
49
Delayed hydrocephalus after excision of a colloid cyst: a case report. 62
35668448 2022
50
First reported case of hydrocephalus in jointly diagnosed bacterial meningitis and a colloid cyst: how Ockham's razor became Hickam's dictum. 62
35608085 2022

Variations for Obstructive Hydrocephalus

Expression for Obstructive Hydrocephalus

Search GEO for disease gene expression data for Obstructive Hydrocephalus.

Pathways for Obstructive Hydrocephalus

GO Terms for Obstructive Hydrocephalus

Cellular components related to Obstructive Hydrocephalus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 astrocyte end-foot GO:0097450 9.26 GFAP AQP4
2 TSC1-TSC2 complex GO:0033596 8.92 TSC2 TSC1

Biological processes related to Obstructive Hydrocephalus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of MAPK cascade GO:0043409 9.8 NF2 NF1 DUSP16
2 lung epithelium development GO:0060428 9.76 SHH FOXJ1
3 negative regulation of Schwann cell proliferation GO:0010626 9.73 NF2 NF1
4 cellular water homeostasis GO:0009992 9.71 AQP4 AQP1
5 negative regulation of T cell differentiation in thymus GO:0033085 9.67 SHH FOXJ1
6 oligodendrocyte differentiation GO:0048709 9.65 SHH OLIG2 NF1
7 water homeostasis GO:0030104 9.33 AQP4 AQP1
8 trans-synaptic signaling by BDNF, modulating synaptic transmission GO:0099183 9.26 PLG PLAT
9 Schwann cell proliferation GO:0014010 9.1 NF2 NF1 GFAP

Sources for Obstructive Hydrocephalus

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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