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MCID: OBS004
MIFTS: 38

Obstructive Hydrocephalus

Categories: Neuronal diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Obstructive Hydrocephalus

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MalaCards integrated aliases for Obstructive Hydrocephalus:

Name: Obstructive Hydrocephalus 12 55 15 73

Classifications:

MalaCards categories:
Anatomical: Neuronal diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:14159
ICD10 33 G91.1
ICD9CM 35 331.4
MeSH 44 D006849
NCIt 50 C116347
SNOMED-CT 68 82346000
UMLS 73 C0549423
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Summaries for Obstructive Hydrocephalus

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MalaCards based summary : Obstructive Hydrocephalus is related to ependymoma and hydrocephalus. An important gene associated with Obstructive Hydrocephalus is PRL (Prolactin), and among its related pathways/superpathways is Neuroscience. The drugs Fluconazole and Amphotericin B have been mentioned in the context of this disorder. Affiliated tissues include brain, pituitary and bone, and related phenotypes are behavior/neurological and cardiovascular system

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Related Diseases for Obstructive Hydrocephalus

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Diseases related to Obstructive Hydrocephalus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 178)
# Related Disease Score Top Affiliating Genes
1 ependymoma 31.6 GFAP SYP
2 hydrocephalus 31.3 GFAP PRL SYP
3 chiari malformation 29.9 GFAP SYP
4 pilocytic astrocytoma 29.7 GFAP NF1
5 neurilemmoma of the fifth cranial nerve 29.5 CRLF1 GFAP NF1
6 hemangioblastoma 29.3 GFAP SYP
7 tuberous sclerosis 29.3 GFAP NF1 SYP
8 congenital non-communicating hydrocephalus 11.5
9 congenital hydrocephalus 11.4
10 hydrocephalus due to congenital stenosis of aqueduct of sylvius 11.4
11 congenital communicating hydrocephalus 11.2
12 meningitis 10.3
13 vestibular disease 10.2 CRLF1 GJB6
14 arteriovenous malformation 10.1
15 neurilemmoma 10.1 GFAP NF1
16 cogan syndrome 10.1 CRLF1 GFAP
17 gliofibroma 10.1 GFAP NF1
18 exophthalmos 10.1 NF1 PRL
19 plexiform schwannoma 10.1 GFAP NF1
20 nodular medulloblastoma 10.1 GFAP SUFU
21 atypical neurofibroma 10.1 GFAP NF1
22 encephalopathy 10.1
23 brachial plexus lesion 10.1 CRLF1 NF1
24 moyamoya disease 1 10.1 CRLF1 NF1
25 mutism 10.1
26 akinetic mutism 10.1
27 bacterial meningitis 10.1
28 arachnoid cysts 10.1
29 sella turcica neoplasm 10.0 PRL SYP
30 tuberculum sellae meningioma 10.0 PRL SYP
31 juvenile pilocytic astrocytoma 10.0 GFAP NF1
32 traumatic brain injury 10.0 AQP4 GFAP
33 abducens nerve disease 10.0 PRL SYP
34 internuclear ophthalmoplegia 10.0 AQP4 NF1
35 granulosa cell tumor of the ovary 10.0 PRL SYP
36 desmoplastic infantile ganglioglioma 10.0 GFAP SYP
37 ganglioglioma 10.0 GFAP SYP
38 extraventricular neurocytoma 10.0 GFAP SYP
39 lung combined type small cell carcinoma 10.0 GFAP SYP
40 trigeminal nerve neoplasm 10.0 CRLF1 GFAP NF1
41 cellular ependymoma 10.0 GFAP SYP
42 chordoid meningioma 10.0 GFAP SYP
43 central nervous system primitive neuroectodermal neoplasm 10.0 GFAP SYP
44 clear cell ependymoma 10.0 GFAP SYP
45 dysembryoplastic neuroepithelial tumor 10.0 GFAP SYP
46 cerebral neuroblastoma 10.0 GFAP SYP
47 subependymal glioma 10.0 GFAP SYP
48 astroblastoma 10.0 GFAP SYP
49 cerebral ventricle cancer 10.0 GFAP SYP
50 pineal gland cancer 10.0 GFAP SYP

Comorbidity relations with Obstructive Hydrocephalus via Phenotypic Disease Network (PDN): (show all 18)


Acute Cystitis Alzheimer Disease
Brain Cancer Brain Compression
Cerebellum Cancer Cerebral Degeneration
Communicating Hydrocephalus Decubitus Ulcer
Deficiency Anemia Epilepsy, Focal, with Speech Disorder and with or Without Mental Retardation
Hypertension, Essential Parkinson Disease, Late-Onset
Pineal Gland Cancer Protein-Energy Malnutrition
Respiratory Failure Schizophreniform Disorder
Swallowing Disorders Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Obstructive Hydrocephalus:



Diseases related to Obstructive Hydrocephalus
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Symptoms & Phenotypes for Obstructive Hydrocephalus

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MGI Mouse Phenotypes related to Obstructive Hydrocephalus:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.7 AQP4 CRLF1 GFAP GJB6 NF1 PRL
2 cardiovascular system MP:0005385 9.43 AQP4 CCDC85C GFAP GJB6 NF1 SUFU
3 nervous system MP:0003631 9.28 AQP4 CCDC85C CRLF1 GFAP GJB6 NF1
Sources

Drugs & Therapeutics for Obstructive Hydrocephalus

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Drugs for Obstructive Hydrocephalus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 38)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fluconazole Approved, Investigational Phase 1, Phase 2 86386-73-4 3365
2
Amphotericin B Approved, Investigational Phase 1, Phase 2 1397-89-3 5280965 14956
3
deoxycholic acid Approved Phase 1, Phase 2 83-44-3 222528
4
Miconazole Approved, Investigational, Vet_approved Phase 1, Phase 2 22916-47-8 4189
5 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 1, Phase 2
6 Hormone Antagonists Phase 1, Phase 2
7 Anti-Bacterial Agents Phase 1, Phase 2
8 Antiparasitic Agents Phase 1, Phase 2
9 Liposomal amphotericin B Phase 1, Phase 2
10 Cytochrome P-450 Enzyme Inhibitors Phase 1, Phase 2
11 Steroid Synthesis Inhibitors Phase 1, Phase 2
12 Amphotericin B, deoxycholate drug combination Phase 1, Phase 2
13 Hormones Phase 1, Phase 2
14 Antiprotozoal Agents Phase 1, Phase 2
15 Antifungal Agents Phase 1, Phase 2
16 Anti-Infective Agents Phase 1, Phase 2
17 Cytochrome P-450 CYP2C9 Inhibitors Phase 1, Phase 2
18 Cytochrome P-450 CYP2C19 Inhibitors Phase 1, Phase 2
19
Magnesium Sulfate Approved, Investigational, Vet_approved Not Applicable 7487-88-9 24083
20
Mannitol Approved, Investigational Not Applicable 69-65-8 453 6251
21
Cyclophosphamide Approved, Investigational Not Applicable 6055-19-2, 50-18-0 2907
22
Mesna Approved, Investigational Not Applicable 3375-50-6 598
23
Vincristine Approved, Investigational Not Applicable 57-22-7, 2068-78-2 5978
24
Etoposide Approved Not Applicable 33419-42-0 36462
25
Cisplatin Approved Not Applicable 15663-27-1 2767 441203 84093
26
Vitamin A Approved, Nutraceutical, Vet_approved Not Applicable 11103-57-4, 68-26-8 445354
27 Mafosfamide Investigational Not Applicable 88859-04-5
28 Tissue Plasminogen Activator Not Applicable
29 Anesthetics Not Applicable
30 Alkylating Agents Not Applicable
31 Antirheumatic Agents Not Applicable
32 Immunologic Factors Not Applicable
33 Retinol palmitate Not Applicable
34 Etoposide phosphate Not Applicable
35 Immunosuppressive Agents Not Applicable
36 Antineoplastic Agents, Alkylating Not Applicable
37 retinol Not Applicable
38 Adjuvants, Immunologic Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effect of Intrathoracic Pressure Regulation on Traumatic Brain Injury Terminated NCT01824589 Phase 4
2 A Randomised Controlled Trial of Lumbar Drainage to Treat Communicating Hydrocephalus After Severe Intraventricular Hemorrhage Completed NCT01041950 Phase 2, Phase 3
3 High-Dose Fluconazole for the Treatment of Cryptococcal Meningitis in HIV-Infected Individuals Completed NCT00885703 Phase 1, Phase 2 Fluconazole;Amphotericin B
4 Prospective Randomized, Controlled Trial for Treatment of Intraventricular Hemorrhage Unknown status NCT01064011 Not Applicable
5 Third Ventriculostomy Versus Shunt for Children With Hydrocephalus Completed NCT01801267 Not Applicable
6 Study of Systemic and Spinal Chemotherapy Followed by Radiation for Infants With Brain Tumors Completed NCT00042367 Not Applicable Induction therapy (Regimen 1, Course 1, Cycle A1;Regimen 1, Course 1, Cycle A2 (Days 22 - 42);Cycle B;Regimen 1, Course 2;Intrathecal Mafosfamide;Regimen 1 Course 2, IT mafosfamide;Regimen 2, Course 1;Regimen 2, Course, 1, Cycle C1;Regimen 2, Course 2
7 Hypothalamic-pituitary Effects After Endoscopic Third Ventriculostomy Terminated NCT01675037

Search NIH Clinical Center for Obstructive Hydrocephalus

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Genetic Tests for Obstructive Hydrocephalus

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Anatomical Context for Obstructive Hydrocephalus

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MalaCards organs/tissues related to Obstructive Hydrocephalus:

41
Brain, Pituitary, Bone, Pineal, Lung, Ovary, Spinal Cord
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Publications for Obstructive Hydrocephalus

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Articles related to Obstructive Hydrocephalus:

(show top 50) (show all 374)
# Title Authors Year
1
Intraventricular haemorrhage and obstructive hydrocephalus in a term neonate: an uncommon presentation of haemophilia B. ( 29848541 )
2018
2
A case of a mobile choroid plexus cyst presenting with different types of obstructive hydrocephalus. ( 29541488 )
2018
3
Management of Obstructive Hydrocephalus in Pregnant Patient. ( 29492141 )
2018
4
Obstructive hydrocephalus and facial nerve palsy secondary to vertebrobasilar dolichoectasia: Case Report. ( 29629227 )
2018
5
Posterior fossa metastasis-associated obstructive hydrocephalus in adult patients: literature review and practical considerations from the Neuro-Oncology Club of the French Society of Neurosurgery. ( 29935321 )
2018
6
Corrigendum: Dusp16 Deficiency Causes Congenital Obstructive Hydrocephalus and Brain Overgrowth by Expansion of the Neural Progenitor Pool. ( 29417959 )
2018
7
Obstructive hydrocephalus secondary to odontoid pannus: case report and review of literature. ( 29644037 )
2018
8
Amenorrhoea and reversible infertility due to obstructive hydrocephalus: literature review and case report. ( 29430977 )
2018
9
Phase-contrast and three-dimensional driven equilibrium (3D-DRIVE) sequences in the assessment of paediatric obstructive hydrocephalus. ( 29850941 )
2018
10
Obstructive hydrocephalus caused by colloid cyst presenting as a schizophrenia-like psychosis. ( 29884711 )
2018
11
Obstructive Hydrocephalus in Newborn Due to Cerebral Atrium Diverticulum Formation: Complete Resolution After Subdural Hematoma Evacuation. ( 29751185 )
2018
12
Iatrogenic obstructive hydrocephalus resulting from Gelfoam accumulation within the cerebral aqueduct: a case report. ( 29946809 )
2018
13
Influenza A(H5N1) Virus Infection in a Child With Encephalitis Complicated by Obstructive Hydrocephalus. ( 29020163 )
2018
14
Acute Obstructive Hydrocephalus due to a Giant Posterior Cerebral Artery Aneurysm in a Pediatric Patient. ( 29719303 )
2018
15
Unusual location of developmental venous anomaly within fourth ventricle causing obstructive hydrocephalus - A case report. ( 29248318 )
2018
16
Ventriculostomy and Risk of Upward Herniation in Patients with Obstructive Hydrocephalus from Posterior Fossa Mass Lesions. ( 29305758 )
2018
17
Case Report of an Obstructive Hydrocephalus Caused by an Unruptured Mesencephalic Arteriovenous Malformation in a Boy and a Review of Literature. ( 29541280 )
2018
18
Non-obstructive hydrocephalus in a giant hemorrhagic prolactinoma. ( 29480687 )
2018
19
Cryptococcal meningitis in an immunocompetent patient with obstructive hydrocephalus: A case report. ( 30195720 )
2018
20
Early Surgical Outcome of Endoscopic Third Ventriculostomy in the Management of Obstructive Hydrocephalus: A Randomized Control Trial. ( 30459856 )
2018
21
Controlled Trial to Compare Therapeutic Efficacy of Endoscopic Third Ventriculostomy Plus Choroid Plexus Cauterization with Ventriculoperitoneal Shunt in Infants with Obstructive Hydrocephalus. ( 30459864 )
2018
22
A Giant Tumefactive Perivascular Space: A Rare Cause of Obstructive Hydrocephalus and Monoparesis. ( 30459922 )
2018
23
Neurosarcoidosis Presenting with Obstructive Hydrocephalus Successfully Treated with Endoscopic Third Ventriculostomy. ( 30146586 )
2018
24
Rehabilitation for a complex patient following cerebellar hemorrhage and obstructive hydrocephalus: A case report. ( 30198821 )
2018
25
Aneurysmal dilation of the vein of Galen and straight sinus with resultant obstructive hydrocephalus. ( 30262543 )
2018
26
Posterior reversible encephalopathy syndrome (PRES) with obstructive hydrocephalus. ( 28408184 )
2017
27
Parkinsonism after chronic subdural haematoma followed by ventriculoperitoneal shunt for obstructive hydrocephalus: a case report. ( 28658987 )
2017
28
Subclinical meningoventriculitis as a cause of obstructive hydrocephalus. ( 29025781 )
2017
29
Management of quadrigeminal arachnoid cyst associated with obstructive hydrocephalus: report on stereotactic ventricular - cystic stenting. ( 28643523 )
2017
30
Obstructive Hydrocephalus due to Intracerebral Alveolar Echinococcosis. ( 29228350 )
2017
31
Obstructive Hydrocephalus Secondary to Enlarged Virchow-Robin Spaces: A Rare Cause of Pulsatile Tinnitus. ( 28268131 )
2017
32
Obstructive Hydrocephalus in Pyridoxine-Dependent Epilepsy: An Uncommon Complication. ( 28216032 )
2017
33
Dusp16 Deficiency Causes Congenital Obstructive Hydrocephalus and Brain Overgrowth by Expansion of the Neural Progenitor Pool. ( 29170629 )
2017
34
Lateral Ventricle to Sylvian Fissure Shunt for Obstructive Hydrocephalus: First Report. ( 28427106 )
2017
35
A case of acute acquired obstructive hydrocephalus in a cat with suspected ischaemic cerebellar infarct. ( 28491457 )
2017
36
Cerebellar ataxia and obstructive hydrocephalus, rare neurologic presentations in patients with systemic lupus erythematosus. ( 28707035 )
2017
37
Multiple supratentorial subependymomas causing obstructive hydrocephalus. ( 28578305 )
2017
38
Ventricular pseudodiverticula from intraparenchymal cerebrospinal fluid dissection secondary to high-grade obstructive hydrocephalus in children: magnetic resonance imaging findings. ( 28644065 )
2017
39
Emergent presentation of Langerhans cell histiocytosis in a pediatric patient: Acute cerebellar involvement causing obstructive hydrocephalus requiring posterior fossa decompression. ( 29379238 )
2017
40
Everolimus Alleviates Obstructive Hydrocephalus due to Subependymal Giant Cell Astrocytomas. ( 28162859 )
2017
41
Cryptococcal meningitis causing obstructive hydrocephalus in a patient on fingolimod. ( 28687690 )
2017
42
A new shunt for obstructive hydrocephalus: ventricle-Sylvian fissure shunt A preliminary report. ( 28264582 )
2017
43
Long-Term Follow-Up of Repeat Endoscopic Third Ventriculostomy in Obstructive Hydrocephalus. ( 28034816 )
2017
44
Complicated acute cerebellitis with obstructive hydrocephalus and tonsillar herniation in a child. ( 28446490 )
2017
45
Medulloblastoma With Obstructive Hydrocephalus in a Young Infant. ( 26555306 )
2017
46
Cysticerci located in the fourth ventricle causing obstructive hydrocephalus: a radiological emergency requiring prompt diagnosis. ( 27192602 )
2016
47
Comparison of 3 and 7 Tesla Magnetic Resonance Imaging of Obstructive Hydrocephalus Caused by Tectal Glioma. ( 27867929 )
2016
48
Acute obstructive hydrocephalus complicating decompression surgery of the craniovertebral junction. ( 27366268 )
2016
49
Obstructive Hydrocephalus Caused by an Unruptured Arteriovenous Malformation Successfully Treated by Endoscopic Third Ventriculostomy After Shunt Dysfunction. ( 28127723 )
2016
50
Transient Obstructive Hydrocephalus in Patients with Intracerebral Hemorrhage: Report of Two Cases ( 29046016 )
2016
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Variations for Obstructive Hydrocephalus

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Expression for Obstructive Hydrocephalus

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Search GEO for disease gene expression data for Obstructive Hydrocephalus.
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Pathways for Obstructive Hydrocephalus

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Pathways related to Obstructive Hydrocephalus according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Neuroscience 4
11.33 GFAP NF1 SYP
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GO Terms for Obstructive Hydrocephalus

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Biological processes related to Obstructive Hydrocephalus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell communication GO:0007154 9.26 GJB6 NF1
2 negative regulation of endothelial cell proliferation GO:0001937 9.16 NF1 PRL
3 regulation of long-term neuronal synaptic plasticity GO:0048169 8.96 NF1 SYP
4 negative regulation of protein import into nucleus GO:0042308 8.62 NF1 SUFU
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Sources for Obstructive Hydrocephalus

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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