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MCID: OBS001
MIFTS: 49

Obstructive Jaundice

Categories: Gastrointestinal diseases, Genetic diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Obstructive Jaundice

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MalaCards integrated aliases for Obstructive Jaundice:

Name: Obstructive Jaundice 12 15 17
Jaundice, Obstructive 44 70
Obstructive Hyperbilirubinemia 12
Cholestatic Jaundice Syndrome 12
Cholestatic Jaundice 12
Jaundice Obstructive 54
Jaundice Cholestatic 54

Classifications:

MalaCards categories:
Global: Genetic diseases
Anatomical: Gastrointestinal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:13603
MeSH 44 D041781
NCIt 50 C34742
SNOMED-CT 67 59848001
UMLS 70 C0022354
Sources

Summaries for Obstructive Jaundice

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MalaCards based summary : Obstructive Jaundice, also known as jaundice, obstructive, is related to bile acid synthesis defect, congenital, 1 and cholecystitis, and has symptoms including icterus and jaundice (not of newborn). An important gene associated with Obstructive Jaundice is GGT1 (Gamma-Glutamyltransferase 1), and among its related pathways/superpathways are Pathways in cancer and Salmonella infection (KEGG). The drugs Lactulose and Nicotinamide have been mentioned in the context of this disorder. Affiliated tissues include pancreas, liver and kidney, and related phenotypes are cardiovascular system and homeostasis/metabolism

Sources

Related Diseases for Obstructive Jaundice

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Diseases in the Obstructive Jaundice family:

Jaundice, Familial Obstructive, of Infancy

Diseases related to Obstructive Jaundice via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1111)
# Related Disease Score Top Affiliating Genes
1 bile acid synthesis defect, congenital, 1 31.9 TTR SLC25A13 ALB
2 cholecystitis 31.5 GPT F2 ALB
3 cholelithiasis 31.3 GPT CRP ALB
4 acute kidney failure 31.3 REN GPT F2 ALB
5 biliary atresia 31.2 GPT GGT1 F2 ALB
6 duodenal ulcer 31.1 TNF IL6 CXCL8
7 acute pancreatitis 31.1 TNF IL6 GPT CXCL8 CRP
8 choledocholithiasis 31.0 SLC17A5 GPT GGT1 F2 CRP ALPP
9 hyperthyroidism 31.0 GPT CRP ALPP ALB
10 extrahepatic cholestasis 31.0 GPT GGT1 ABCC2
11 klatskin's tumor 30.9 GPT F2 ALB
12 hepatic coma 30.9 GPT F2 ALB
13 bile duct cancer 30.9 IL6 GPT ALB ABCC2
14 acute cholangitis 30.9 IL6 GPT F2 CRP ALB
15 lymphadenitis 30.8 TNF CXCL8 CRP
16 ileus 30.8 TNF IL6 F2 CRP
17 portal hypertension 30.8 TNF GPT F2 EDN1 CXCL8 ALB
18 cholestasis 30.8 SLC25A13 SLC17A5 GPT GGT1 F2 ALPP
19 kidney disease 30.7 TTR TNF REN IL6 EDN1 CRP
20 volvulus of midgut 30.7 GPT CRP ALB
21 pustulosis of palm and sole 30.6 TNF CXCL8 CRP
22 gastric ulcer 30.6 TNF IL6 CXCL8
23 afferent loop syndrome 30.6 GPT ALB
24 esophageal varix 30.6 GPT F2 ALB
25 fascioliasis 30.6 SLC17A5 GPT GGT1 ALPP ALB
26 disseminated intravascular coagulation 30.6 TNF IL6 GPT F2 CRP
27 duodenitis 30.6 TNF CRP ALB
28 amyloidosis 30.6 TTR TNF IL6 CRP ALB
29 peritonitis 30.5 TNF IL6 F2 CXCL8 CRP ALB
30 ascending cholangitis 30.5 GPT F2 CRP ALB
31 miliary tuberculosis 30.5 TNF CRP ALB
32 hydronephrosis 30.5 REN IL6 CXCL8 CRP ALB
33 bacterial infectious disease 30.4 TNF IL6 CXCL8 CRP
34 hepatorenal syndrome 30.4 REN GPT F2 EDN1 ALB
35 varicose veins 30.4 TNF IL6 F2 CXCL8
36 myeloma, multiple 30.4 TNF KIT IL6 IL2 CXCL8 ALB
37 clonorchiasis 30.4 TNF IL2 CXCL8
38 abdominal tuberculosis 30.4 TNF GPT F2 CRP ALB
39 acute liver failure 30.4 SLC17A5 GPT F2
40 cholangitis 30.3 TNF IL6 IL2 GPT GPBAR1 GGT1
41 hepatitis a 30.3 TNF GPT F2 ALB
42 acute kidney tubular necrosis 30.3 TNF REN IL6 GPT F2 ALB
43 glucose intolerance 30.3 TNF IL6 GPT CRP ALB
44 autoimmune hepatitis 30.3 TNF SLC17A5 GPT GGT1 F2 ALB
45 parenteral nutrition-associated cholestasis 30.3 SLC17A5 GPT GGT1 ALPP
46 aortic aneurysm, familial abdominal, 1 30.3 TNF REN IL6 CXCL8 CRP ALB
47 viral hepatitis 30.3 TNF SLC17A5 IL6 IL2 GPT GGT1
48 mental depression 30.3 TNF IL6 CRP
49 intestinal obstruction 30.3 TNF KIT IL6 GPT CRP ALB
50 drug-induced hepatitis 30.3 TNF GPT ALB

Graphical network of the top 20 diseases related to Obstructive Jaundice:



Diseases related to Obstructive Jaundice
Sources

Symptoms & Phenotypes for Obstructive Jaundice

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UMLS symptoms related to Obstructive Jaundice:


icterus; jaundice (not of newborn)

MGI Mouse Phenotypes related to Obstructive Jaundice:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.25 ALB CEACAM1 CLDN4 CRP EDN1 F2
2 homeostasis/metabolism MP:0005376 10.19 ABCC2 ALB CEACAM1 CLDN4 CRP EDN1
3 growth/size/body region MP:0005378 10.17 ABCC2 CEACAM1 CLDN4 EDN1 F2 GGT1
4 endocrine/exocrine gland MP:0005379 10.07 ALB CEACAM1 EDN1 F2 GGT1 GPBAR1
5 digestive/alimentary MP:0005381 10.06 ALB CEACAM1 EDN1 F2 IL2 IL6
6 liver/biliary system MP:0005370 9.76 ABCC2 ALB GPBAR1 IL2 IL6 KIT
7 muscle MP:0005369 9.56 ALB CEACAM1 EDN1 F2 IL6 KIT
8 renal/urinary system MP:0005367 9.36 ABCC2 ALB CLDN4 EDN1 GGT1 GPBAR1
Sources

Drugs & Therapeutics for Obstructive Jaundice

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Drugs for Obstructive Jaundice (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 53)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lactulose Approved Phase 4 4618-18-2 11333
2
Nicotinamide Approved, Investigational Phase 3 98-92-0 936
3
Folic acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
4
Methionine Approved, Nutraceutical Phase 3 63-68-3 6137
5
Niacin Approved, Investigational, Nutraceutical Phase 3 59-67-6 938
6 Vitamins Phase 3
7 Micronutrients Phase 3
8 Antimetabolites Phase 3
9 Pharmaceutical Solutions Phase 3
10 Trace Elements Phase 3
11 Vasodilator Agents Phase 3
12 Vitamin B9 Phase 3
13 Nutrients Phase 3
14 Hypolipidemic Agents Phase 3
15 Vitamin B Complex Phase 3
16 Vitamin B3 Phase 3
17 Folate Phase 3
18 Lipid Regulating Agents Phase 3
19 Nicotinic Acids Phase 3
20
Ursodeoxycholic acid Approved, Investigational Phase 2 128-13-2 31401
21
Neostigmine Approved, Vet_approved Phase 1, Phase 2 59-99-4 4456
22 Gastrointestinal Agents Phase 2
23 Cholinergic Agents Phase 1, Phase 2
24 Cholinesterase Inhibitors Phase 1, Phase 2
25 Anti-Inflammatory Agents Phase 1, Phase 2
26 Neurotransmitter Agents Phase 1, Phase 2
27 Liver Extracts Phase 1, Phase 2
28 Omega 3 Fatty Acid Phase 1, Phase 2
29 Olive Phase 1, Phase 2
30 Soy Bean Phase 1, Phase 2
31 Fat Emulsions, Intravenous Phase 1, Phase 2
32
Bilirubin Phase 1, Phase 2 635-65-4 5280352
33
Methylene blue Approved, Investigational Phase 1 61-73-4
34
Norepinephrine Approved Phase 1 51-41-2 439260
35
Pancrelipase Approved, Investigational 53608-75-6
36
Trioxsalen Approved 3902-71-4 5585
37
Prednisone Approved, Vet_approved 53-03-2 5865
38
Ceftriaxone Approved 73384-59-5 5479530 5361919
39 pancreatin
40 Dihematoporphyrin Ether
41 Ether
42 Photosensitizing Agents
43 Hematoporphyrins
44 Dermatologic Agents
45 Hematoporphyrin Derivative
46 Immunoglobulin G
47 Immunoglobulins
48 Immunoglobulins, Intravenous
49 Antibodies
50 Anti-Bacterial Agents

Interventional clinical trials:

(show all 42)
# Name Status NCT ID Phase Drugs
1 Phase 4 Study :Human Kidney Histopathology in Acute Obstructive Jaundice: a Prospective Study Completed NCT01090193 Phase 4
2 Re-intervention for Occluded Biliary Metal Stent in Malignant Distal Bile Duct Obstruction: a Prospective Randomized Multi-center Trial Comparing Covered and Uncovered Metal Stent Completed NCT01315522 Phase 4
3 Preoperative Biliary Drainage for the Lower Malignant Obstructive Jaundice: A Phase III, Randomized, Controlled, Single Center Study. Unknown status NCT01744938 Phase 3
4 A Multicenter, Double-Blind, Placebo-Controlled, Randomized Trial of Efficacy and Safety of Remaxol®, a Solution for Intravenous Infusions Produced by STPF "POLYSAN" (Russia), in Patients With Mechanical Jaundice of Non-Malignant Origin Completed NCT03418935 Phase 3 Remaxol (succinate + methionine + inosine + nicotinamide);Ringer's Solution
5 A Multicenter, Double-blind, Placebo-controlled, Randomized Trial of the Efficacy and Safety of Remaxol®, a Solution for Infusions Produced by STPF POLYSAN (Russia), in Patients With Malignant Mechanical Jaundice Completed NCT03416062 Phase 3 Remaxol®;Ringer's Solution
6 Comparison Between Two Methods of Bilateral Stenting for Malignant Hilar Obstruction Withdrawn NCT01622803 Phase 3
7 The Effect of Ursodeoxycholic Acid in Liver Functional Restoration of Patients With Obstructive Jaundice After Endoscopic or Surgical Treatment Unknown status NCT01688375 Phase 2 Ursodeoxycholic Acid
8 The Prevention and Treatment of SIRS in Patients With Cholestatic Jaundice After Operation. Unknown status NCT02279147 Phase 1, Phase 2 neostigmine methylsulfate，raceanisodamine hydrochloride
9 A Double Blind, Randomized Controlled Prospective Trial of Endo-biliary Radio-frequency Ablation for Maintenance of Metal Stent Patency in Patients With Malignant Obstructive Jaundice Unknown status NCT01275768 Phase 1, Phase 2
10 Investigation of the Effect of Intraductal Radiofrequency Ablation in Inoperable Biliopancreatic Tumors Complicated With Obstructive Jaundice Completed NCT02468076 Phase 2
11 Self Expanding Metal Stents (SEMS) or Plastic Stents to Relieve Obstruction of Obstructive Jaundice Prior to Resection of Periampullary Tumors. Completed NCT02166840 Phase 2
12 Compassionate Use of an Intravenous Fat Emulsion Comprised of Soy Oil, Medium Chain Triglycerides, Olive Oil, and Fish Oil for Neonates With Parenteral Nutrition Induced Liver Injury Terminated NCT02721277 Phase 1, Phase 2 SMOFlipid
13 Effect of Methylene Blue on Perioperative Organ Function in Patients With Obstructive Jaundice Enrolling by invitation NCT04109859 Phase 1 Saline;Methylene Blue
14 The Preventive Effects of Pre-treatment With Methylene Blue for Vascular Paralysis of the Patients With Obstructive Jaundice During Operation Unknown status NCT03406676 Methylene Blue
15 Quorum Sensing Signal Molecules (QSSMs) and Immune Dysfunction in Patients Undergoing Endoscopic Retrograde Cholangiopancreatography (ERCP) for Obstructive Jaundice Unknown status NCT01367821
16 The Role of Cholangioscopy and Biliary Radio Frequency Ablation in the Management of Occluded Biliary Self-expanding Metal Stent. Unknown status NCT03133026
17 Endoscopic Access Loop With Bilio-enteric Anastomosis: A Prospective Randomized Comparison Between Gastric and Subcutaneous Accesses Unknown status NCT03252379
18 Endoscopic Retrograde Cholangiopancreatography, Endoscopic Ultrasound and Interventional Endoscopy in Pancreatico-biliary, Gastrointestinal and Esophageal Disorders Unknown status NCT01438385
19 Safety and Efficacy of n-3 Fatty Acid-based Parenteral Nutrition in Patients With Obstructive Jaundice: A Propensity-matched Study Completed NCT03376945 trail cohort;control cohort
20 Endoscopic Ultrasound Evaluation of the Common Bile Duct in Patients With Obstructive Jaundice Due to Bilio-Pancreatic Malignancies: A Multicenter Prospective Study Completed NCT03494023
21 Prospective Study on the Comparison Between the Clinicopathological Outcomes According to the Methods of Preoperative Biliary Drainage in Periampullary Cancers Causing Obstructive Jaundice Completed NCT01134276
22 Endoscopic Ultrasound-guided Biliary Drainage for Malignant Biliary Obstruction After Failed ERCP: a Single Italian Center Experience Completed NCT03510754
23 A Double-blind, Randomized, Controlled Trial of Air Insufflation Versus Carbon Dioxide Insufflation During Endoscopic Retrograde Cholangiopancreatography (ERCP). Completed NCT01321203
24 Biliary Cannulation During Endoscopic Retrograde Cholangiopancreatography: Precut Versus Conventional Cannulation. A Prospective Randomized Study Completed NCT02477228
25 Endoscopic Versus Percutaneous Biliary Drainage for Resectable Pancreatic Head Cancer With Hyperbilirubinemia and Impact on Pancreaticoduodenectomy: A Prospective Cohort Study Completed NCT04823832
26 Multicenter Prospective Randomized Controlled Trial of the Nitinol ZILVER Expandable Endoprosthesis in the Palliation of Extrahepatic Malignant Biliary Obstruction Completed NCT00196105
27 Endoscopic Versus Percutaneous Biliary Drainage For Hilar Block Due to Carcinoma Gall Bladder: A Randomized Prospective Trial and Quality Of Life Assessment Completed NCT00409864
28 The Status of Advanced Endoscopy in the Era of COVID-19: a Multicenter Study Completed NCT04385147
29 Full Data BDI Digestif RSCM Completed NCT04582240
30 Observational Study for Safety and Efficacy of Photodynamic Therapy for Bile Duct Invasion of Hepatocellular Carcinoma Completed NCT01506115 Photofrin
31 Influence of Percutaneous Biliary Drainage on the Change of Enzyme Activity of Matrix Metalloproteinases in the Serum of Patients With Malignant Obstructive Hyperbilirubinemia Recruiting NCT04801914
32 Treatment of Obstructive Jaundice in Autoimmune Pancreatitis and/or Immunoglobulin G4-related Sclerosing Cholangitis by Corticosteroids Recruiting NCT02797665 corticosteroids
33 The Influence of Antibiotics on the Incidence of Biliary Tract Infections After PTCD for Malignant Obstructive Jaundice Recruiting NCT04620577
34 Multicenter RCT Comparing Two Brushes of Different Diameters for Biliary Stenosis: RX Cytology Brush, BOSTON vs. Infinity® Brush, US Endoscopy. BIB Study (BIliary Brushing) Recruiting NCT04251013
35 Preoperative Portal Vein Embolization Using Coils Plus TAGM vs Multiple Coils for Patients With Perihilar Cholangiocarcinoma or Hepatocellular Carcinoma: a Randomized Controlled Study Recruiting NCT04386772
36 A Randomized Trial Comparing Covered Metal and Plastic Stents for Preoperative Biliary Decompression in Pancreatic Cancer Active, not recruiting NCT01191814
37 Multicenter Randomized Trial Comparing Covered Metal and Plastic Stents for Preoperative Biliary Decompression in Pancreatic Cancer Active, not recruiting NCT01675908
38 Process Optimization of Preoperative Biliary Drainage in Patients With Malignant Obstructive Jaundice of Extrahepatic Bile Duct: A Multi-center, Prospective, Open-labeled, Real World Study Based on Electronic Data Capture System Not yet recruiting NCT03527875
39 A Multisite, Open-label, Prospective Cohort Study Investigating Huaier Granule Combined With Biliary Drainage for Treatment of Malignant Obstructive Jaundice（MOJ） Not yet recruiting NCT03491254
40 Prospective Evaluation of the Use of a Biodegradable Endoprothesis in the Prevention of Post-Endoscopic Retrograde CholoangioPancreatography Pancreatitis Not yet recruiting NCT03977779
41 preGallstep: One-step Laparoscopic Cholecystectomy, Common Bile Duct Exploration and Stone Extraction Versus Two-step Endoscopic Retrograde Cholangiography and Stone Extraction Plus Laparoscopic Cholecystectomy for Common Bile Duct Stones Not yet recruiting NCT04801238
42 Preoperative Endoscopic Biliary Drainage With Self Expanding Metal Stents (SEMS) vs. Direct Surgical Resection for Patients With Severe Obstructive Jaundice Terminated NCT03820544

Search NIH Clinical Center for Obstructive Jaundice

Cochrane evidence based reviews: jaundice, obstructive

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Genetic Tests for Obstructive Jaundice

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Anatomical Context for Obstructive Jaundice

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MalaCards organs/tissues related to Obstructive Jaundice:

40
Pancreas, Liver, Kidney, Heart, Myeloid, Lymph Node, Skin
Sources

Publications for Obstructive Jaundice

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Articles related to Obstructive Jaundice:

(show top 50) (show all 7488)
# Title Authors PMID Year
1
[Analysis of tear enzymes in the diagnosis of obstructive jaundice associated with subhepatic cholestasis]. 54 61
19143075 2008
2
CEA, CA 19-9, and CA 125 in the differential diagnosis of benign and malignant pancreatic diseases with or without jaundice. 54 61
17262731 2007
3
Contrasting liver function test patterns in obstructive jaundice due to biliary strictures [corrected] and stones. 61 54
15625352 2005
4
[Clinical study on the changes of growth hormone/insulin-like growth factor-I axis in patient with obstructive jaundice]. 54 61
11702667 2001
5
Factors predicting nutritional derangements in patients with obstructive jaundice: multivariate analysis. 61 54
11344390 2001
6
Activity of class I and II isoenzymes of alcohol dehydrogenase measured by a fluorometric method in the sera of patients with obstructive jaundice. 61 54
9247733 1997
7
Clinical values of CA19-9, CA125 and CEA in malignant obstructive jaundice. 61 54
7634181 1995
8
Discrepancies between lipoprotein(a) concentrations in icteric sera measured by immunonephelometry and electroimmunodiffusion. 54 61
8200119 1994
9
T-lymphocyte transformation in experimental obstructive jaundice: the role of serum-suppressive factors. 54 61
8109118 1993
10
Role of endogenous bile on basal and postprandial CCK release in humans. 54 61
8391974 1993
11
Human lymphocyte responsiveness is not enhanced by relief of biliary obstruction: an in-vitro study. 61 54
2025801 1991
12
Bile acids in human plasma interfere with cholecystokinin bioassay using dispersed pancreatic acini. 61 54
1995267 1991
13
[Reduction of erythrocyte membrane band 4.2 protein in patients with obstructive jaundice]. 61 54
2255052 1990
14
A combination of raised serum AST:ALT ratio and erythrocyte mean cell volume level detects excessive alcohol consumption. 54 61
2342668 1990
15
Malignant Melanoma: a Rare Cause of Obstructive Jaundice. 61
32948962 2021
16
[Expert consensus on enhanced recovery concept for the application of standardized management on obstructive jaundice]. 61
33706439 2021
17
Sometimes the Best Solution Is Transit Bipartition: Video Case Report. 61
33471312 2021
18
Laparoscopic-assisted transjejunal endoscopic management of intrahepatic calculi and anastomotic stricture in a patient with Roux-en-Y hepaticojejunostomy. 61
32964874 2021
19
Hemosuccus Pancreaticus and Obstructive Jaundice: Two Rare Complications of Chronic Pancreatitis Treated by Arterial Embolization. 61
33728615 2021
20
Unresectable malignant obstructive jaundice: a 2-year experience of EUS-guided biliary drainage. 61
33653733 2021
21
An iodine-125 seed strand combined with a metal stent versus a metal stent alone for obstructive jaundice caused by pancreatic ductal adenocarcinoma. 61
33309002 2021
22
Limy Bile Syndrome Causing Obstructive Jaundice: A Case Series and Review of the Literature. 61
33761090 2021
23
Obstructive jaundice due to acute acalculous cholecystitis: 'Mirizzi-like syndrome'. 61
33785604 2021
24
A novel nomogram for predicting the risk of major complications after pancreaticoduodenectomy in patients with obstructive jaundice. 61
33711328 2021
25
An Elusive Cause of Recurrent Obstructive Jaundice Post-ERCP and Cholecystectomy. 61
33012485 2021
26
Inhibition of the norepinephrine transporter rescues vascular hyporeactivity to catecholamine in obstructive jaundice. 61
33775645 2021
27
Improving biliary stent patency for malignant obstructive jaundice using endobiliary radiofrequency ablation: experience in 150 patients. 61
33788032 2021
28
N-acetyl cysteine treatment mitigates biomarkers of oxidative stress in different tissues of bile duct ligated rats. 61
32510264 2021
29
Inhibition of heat shock protein 90 alleviates cholestatic liver injury by decreasing IL-1β and IL-18 expression. 61
33603849 2021
30
Treatment response and long-term outcomes in biliary ascariasis: A prospective study. 61
33752976 2021
31
Effect of COVID-19 pandemic on workflows and infection prevention strategies of endoscopy units in Hungary: a cross-sectional survey. 61
33657994 2021
32
Personalized Approach to the Role of Endoscopic Ultrasound in the Diagnosis and Management of Pancreaticobiliary Malignancies. 61
33806458 2021
33
Double rarity: malignant masquerade biliary stricture in a situs inversus totalis patient. 61
33743673 2021
34
Metastatic Infiltration of Anaplastic Carcinoma of the Pancreas Into the Portal Venous System: A Masquerading Cause of Expansive Portal Venous Thrombosis. 61
33767127 2021
35
Carbon ion radiotherapy for patients with hepatocellular carcinoma in the caudate lobe carbon ion radiotherapy for hepatocellular carcinoma in caudate lobe. 61
33350034 2021
36
An Unusual Etiology of Obstructive Jaundice in a Newly Diagnosed Celiac Disease Patient. 61
33723549 2021
37
Pancreaticoduodenectomy combined with splenectomy for a patient with pancreatic cancer and pancytopenia due to liver cirrhosis: Case report. 61
33689973 2021
38
Neutrophil extracellular traps enhance procoagulant activity and thrombotic tendency in patients with obstructive jaundice. 61
33159371 2021
39
Revisiting Quincke's Triad: A Case of Idiopathic Hepatic Artery Aneurysm Presenting with Obstructive Jaundice. 61
33157248 2021
40
A case of endoscopic ultrasound-guided hepaticogastrostomy for obstructive jaundice caused by intraductal papillary mucinous neoplasm-associated pancreatobiliary fistula. 61
33590462 2021
41
A cohort study of hepatectomy-related complications and prediction model for postoperative liver failure after major liver resection in 1,441 patients without obstructive jaundice. 61
33708932 2021
42
Cannabinoid Receptor-2 Activation in Keratinocytes Contributes to Elevated Peripheral β-Endorphin Levels in Patients With Obstructive Jaundice. 61
33560661 2021
43
Denture as an unexpected cause of obstructive jaundice. 61
33540442 2021
44
Emergency open surgery with a duodenotomy and successful removal of an impacted basket following a complicated endoscopic retrograde cholangiopancreatography procedure: a case report. 61
33618756 2021
45
Intraductal papillary neoplasm of intrahepatic bile ducts complicated by chronic disseminated intravascular coagulation and thrombosis: A case report. 61
33592896 2021
46
Retrospective analysis of T-lymphocyte subsets and cytokines in malignant obstructive jaundice before and after external and internal biliary drainage. 61
33641475 2021
47
Extrahepatic cholangiocarcinoma: Current status of endoscopic approach and additional therapies. 61
33708349 2021
48
Biliary stent combined with iodine-125 seed strand implantation in malignant obstructive jaundice. 61
33585626 2021
49
A case of mixed neuroendocrine non-neuroendocrine neoplasm of the distal bile duct with biliary intraepithelial neoplasia. 61
32643120 2021
50
Robotic Pancreaticoduodenectomy for a Technically Challenging Pancreatic Head Cancer. 61
33565012 2021
Sources

Variations for Obstructive Jaundice

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Expression for Obstructive Jaundice

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Search GEO for disease gene expression data for Obstructive Jaundice.
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Pathways for Obstructive Jaundice

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Pathways related to Obstructive Jaundice according to GeneCards Suite gene sharing:

(show all 26)
# Super pathways Score Top Affiliating Genes
1
Pathways in cancer 36
12.7 KIT IL6 IL2 F2 EDN1 CXCL8
2
Salmonella infection (KEGG) 36
Show member pathways
 12.64 TNF IL6 F2 CXCL8 CLDN4
3
Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions 64
Show member pathways
 12.23 TNF IL6 IL2 CXCL8
4
Immune response IFN alpha/beta signaling pathway 23
Show member pathways
 12.13 TNF KIT IL6 IL2 CXCL8
5
IL-1 Family Signaling Pathways 64
Show member pathways
 12.12 TNF IL6 EDN1 CXCL8
6
Yersinia infection 36
11.95 TNF IL6 IL2 CXCL8
7
Spinal Cord Injury 1
11.86 TNF IL6 IL2 CXCL8
8
Glucocorticoid receptor regulatory network 1
11.72 IL6 IL2 CXCL8
9
AGE-RAGE signaling pathway in diabetic complications 36
11.71 TNF IL6 EDN1 CXCL8
10
Innate Lymphoid Cell Differentiation Pathways 64
11.7 TNF KIT IL2
11
Th1 Differentiation Pathway 64
Show member pathways
 11.67 TNF IL6 IL2
12
Pertussis 36
11.67 TNF IL6 CXCL8
13
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 1
Show member pathways
 11.66 TNF IL2 CXCL8
14
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 64
11.62 TNF KIT IL6 IL2 CEACAM1
15
Dendritic Cells Developmental Lineage Pathway 64
11.54 TNF KIT IL6 IL2
16
Legionellosis 36
11.52 TNF IL6 CXCL8
17
Selenium Micronutrient Network 1
Show member pathways
 11.5 TNF IL6 IL2 GGT1 F2 CRP
18
Photodynamic therapy-induced AP-1 survival signaling. 1
11.45 TNF IL6 IL2
19
Malaria 36
11.43 TNF IL6 CXCL8
20
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.42 TNF IL6 IL2 CXCL8
21
Interleukin-10 signaling 65
11.41 TNF IL6 CXCL8
22
FOXA2 and FOXA3 transcription factor networks 1
11.36 TTR F2 ALB
23
Lung fibrosis 1
11.36 TNF IL6 EDN1 CXCL8
24
Antifolate resistance 36
11.12 TNF IL6 ABCC2
25
Cytokines and Inflammatory Response 1
11.07 TNF IL6 IL2
26
Overview of nanoparticle effects 1
10.54 TNF IL6 CXCL8 CRP
Sources

GO Terms for Obstructive Jaundice

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Cellular components related to Obstructive Jaundice according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 TTR TNF REN IL6 IL2 F2
2 extracellular space GO:0005615 9.44 TTR TNF REN KIT IL6 IL2

Biological processes related to Obstructive Jaundice according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.96 TNF KIT IL6 CXCL8 CRP
2 cellular protein metabolic process GO:0044267 9.84 TTR IL6 F2 ALB
3 cytokine-mediated signaling pathway GO:0019221 9.77 TNF KIT IL6 IL2 CXCL8
4 response to lipopolysaccharide GO:0032496 9.76 REN GGT1 EDN1 ABCC2
5 cellular response to lipopolysaccharide GO:0071222 9.73 TNF IL6 CXCL8 ABCC2
6 inflammatory response GO:0006954 9.73 TNF KIT IL6 CXCL8 CRP ABCC2
7 cellular response to drug GO:0035690 9.7 REN EDN1 ABCC2
8 positive regulation of smooth muscle cell proliferation GO:0048661 9.69 TNF IL6 EDN1
9 positive regulation of MAP kinase activity GO:0043406 9.65 TNF KIT EDN1
10 positive regulation of DNA-binding transcription factor activity GO:0051091 9.62 TNF KIT IL6 EDN1
11 acute-phase response GO:0006953 9.58 IL6 F2 CRP
12 thyroid hormone transport GO:0070327 9.55 TTR ABCC2
13 vascular endothelial growth factor production GO:0010573 9.49 TNF IL6
14 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.46 TNF KIT IL6 IL2
15 negative regulation of lipid storage GO:0010888 9.13 TNF IL6 CRP
16 positive regulation of JAK-STAT cascade GO:0046427 8.92 TNF KIT IL6 F2

Molecular functions related to Obstructive Jaundice according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 TNF IL6 IL2 EDN1 CXCL8
Sources

Sources for Obstructive Jaundice

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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