Obstructive Jaundice disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: OBS001 MIFTS: 52	Obstructive Jaundice Categories: Gastrointestinal diseases, Genetic diseases
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Aliases & Classifications for Obstructive Jaundice

MalaCards integrated aliases for Obstructive Jaundice:

Name: Obstructive Jaundice ¹² ¹⁵

Jaundice, Obstructive ⁴⁴ ⁷³

Obstructive Hyperbilirubinemia ¹²

Cholestatic Jaundice Syndrome ¹²

Cholestatic Jaundice ¹²

Jaundice Obstructive ⁵⁵

Jaundice Cholestatic ⁵⁵

Classifications:

MalaCards categories:
Global: Genetic diseases
Anatomical: Gastrointestinal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:13603

MeSH ⁴⁴ D041781

NCIt ⁵⁰ C34742

SNOMED-CT ⁶⁸ 155832005 197452009 266545005 more

UMLS ⁷³ C0022354

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Summaries for Obstructive Jaundice

MalaCards based summary : Obstructive Jaundice, also known as jaundice, obstructive, is related to cholecystitis and abdominal tuberculosis, and has symptoms including icterus and jaundice (not of newborn). An important gene associated with Obstructive Jaundice is ALPP (Alkaline Phosphatase, Placental), and among its related pathways/superpathways are IL-1 Family Signaling Pathways and Folate Metabolism. The drugs Lactulose and Ceftriaxone have been mentioned in the context of this disorder. Affiliated tissues include liver, pancreas and lung, and related phenotypes are growth/size/body region and homeostasis/metabolism

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Related Diseases for Obstructive Jaundice

Diseases in the Obstructive Jaundice family:

Jaundice, Familial Obstructive, of Infancy

Diseases related to Obstructive Jaundice via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 410)

#	Related Disease	Score	Top Affiliating Genes
1	cholecystitis	30.6	ALB F2 GPT
2	abdominal tuberculosis	30.5	ALB F2
3	hepatitis	30.4	F2 GGT1 GPT SLC17A5 TNF
4	fascioliasis	29.9	ALB ALPP GPT SLC17A5
5	cholangiocarcinoma	29.9	ALB GGT1 HGF IL6
6	biliary atresia	29.8	ALB GPT HGF
7	hepatorenal syndrome	29.8	ALB EDN1 F2 REN
8	prostatitis	29.3	CXCL8 IL6 TNF
9	gastroenteritis	29.3	ALB CXCL8 IL6 TNF
10	monocytic leukemia	29.2	CXCL8 IL6 TNF
11	choledocholithiasis	29.2	ALB ALPP F2 GPT SLC17A5
12	portal hypertension	29.2	ALB EDN1 F2 GPT TNF
13	diabetes mellitus	29.1	ALB EDN1 IL6 REN TNF
14	sclerosing cholangitis	29.1	ALB GGT1 GPBAR1 TNF
15	hepatic tuberculosis	29.1	ALB ALPP F2 GGT1 GPT
16	clonorchiasis	29.0	CD79A CXCL8 TNF
17	ulcerative colitis	29.0	CXCL8 IL6 TNF
18	cholestasis	28.9	ALPP F2 GGT1 GPT SLC25A13
19	biliary tract disease	28.5	ALB F2 GGT1 GPBAR1 SLC25A13
20	cholangitis	28.4	ALB F2 GGT1 GPBAR1 GPT IL6
21	peritonitis	28.3	ALB CXCL8 F2 IL6 TNF
22	hepatocellular carcinoma	28.0	ALB CXCL8 F2 GGT1 HGF IL6
23	myeloma, multiple	27.7	ALB CD79A CXCL8 HGF IL6 TNF
24	liver disease	27.5	ALB F2 GGT1 GPT HGF SLC17A5
25	liver cirrhosis	27.5	ALB EDN1 F2 GGT1 GPT HGF
26	mirizzi syndrome	11.2
27	biliary malformation with renal tubular insufficiency	11.2
28	cholestasis, benign recurrent intrahepatic, 1	11.2
29	acth deficiency, isolated	11.0
30	cholestasis, benign recurrent intrahepatic, 2	11.0
31	bile acid synthesis defect, congenital, 1	11.0
32	congenital disorder of glycosylation, type ik	11.0
33	paraquat poisoning	11.0	GPT SLC17A5
34	acute adrenal insufficiency	10.9	IL6 REN
35	pyridoxine deficiency	10.9	GPT SLC17A5
36	paramyloidosis	10.9	ALB TTR
37	scorpion envenomation	10.9	IL6 TNF
38	benign essential hypertension	10.8	ALB REN
39	leukomalacia	10.8	IL6 TNF
40	angioimmunoblastic lymphadenopathy with dysproteinemia	10.8	IL6 TNF
41	alkaline phosphatase, plasma level of, quantitative trait locus 1	10.8	ALPP GGT1
42	antipyrine metabolism	10.8	ALB F2
43	non-a-e hepatitis	10.8	ALB F2
44	kidney papillary necrosis	10.8	ALB REN
45	malignant renovascular hypertension	10.8	EDN1 REN
46	hepatoportal sclerosis	10.8	F2 GPT
47	sudden sensorineural hearing loss	10.7	F2 IL6
48	null-cell leukemia	10.7	IL6 TNF
49	primary hepatic neuroendocrine carcinoma	10.7	ALPP GPT
50	intestinal impaction	10.7	F2 REN

Graphical network of the top 20 diseases related to Obstructive Jaundice:

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Symptoms & Phenotypes for Obstructive Jaundice

UMLS symptoms related to Obstructive Jaundice:

icterus, jaundice (not of newborn)

MGI Mouse Phenotypes related to Obstructive Jaundice:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	growth/size/body region	MP:0005378	9.96	EDN1 F2 GGT1 GPBAR1 HGF IL6
2	homeostasis/metabolism	MP:0005376	9.93	EDN1 TTR F2 GGT1 GPBAR1 IL6
3	liver/biliary system	MP:0005370	9.5	GPBAR1 HGF IL6 ALB SLC25A13 CD79A
4	renal/urinary system	MP:0005367	9.23	GGT1 GPBAR1 IL6 REN ALB SLC25A13

Sources

Drugs & Therapeutics for Obstructive Jaundice

Drugs for Obstructive Jaundice (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 81)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Lactulose

Approved

Phase 4

4618-18-2

11333

Ceftriaxone

Approved

Phase 4

73384-59-5

5479530 5361919

Ofloxacin

Approved

Phase 4

82419-36-1

4583

Levofloxacin

Approved, Investigational

Phase 4

100986-85-4

149096

Renal Agents

Phase 4

Cytochrome P-450 CYP1A2 Inhibitors

Phase 4

Cytochrome P-450 Enzyme Inhibitors

Phase 4

Topoisomerase Inhibitors

Phase 4

Anti-Bacterial Agents

Phase 4,Not Applicable

Antibiotics, Antitubercular

Phase 4,Not Applicable

Anti-Infective Agents

Phase 4,Not Applicable

Antitubercular Agents

Phase 4

Simvastatin

Approved

Phase 3

79902-63-9

54454

Ezetimibe

Approved

Phase 3

163222-33-1

150311

Trioxsalen

Approved

Phase 2, Phase 3,Not Applicable

3902-71-4

5585

Nicotinamide

Approved, Investigational, Nutraceutical

Phase 3

98-92-0

936

Niacin

Approved, Investigational, Nutraceutical

Phase 3

59-67-6

938

Methionine

Approved, Nutraceutical

Phase 3

63-68-3

6137

Folic Acid

Approved, Nutraceutical, Vet_approved

Phase 3

59-30-3

6037

Atorvastatin Calcium

Phase 3

134523-03-8

Rosuvastatin Calcium

Phase 3

147098-20-2

Hematoporphyrin Derivative

Phase 2, Phase 3,Not Applicable

Nicotinic Acids

Phase 3

Dihematoporphyrin Ether

Phase 2, Phase 3,Not Applicable

Hydroxymethylglutaryl-CoA Reductase Inhibitors

Phase 3

Hypolipidemic Agents

Phase 3

Vitamins

Phase 3

Anticholesteremic Agents

Phase 3

Lipid Regulating Agents

Phase 3

Antimetabolites

Phase 3

Calcium, Dietary

Phase 3

Micronutrients

Phase 3

Trace Elements

Phase 3

Vasodilator Agents

Phase 3

Vitamin B Complex

Phase 3

Pharmaceutical Solutions

Phase 3

Vitamin B3

Nutraceutical

Phase 3

Folate

Nutraceutical

Phase 3

Vitamin B9

Nutraceutical

Phase 3

Menthol

Approved

Phase 2

2216-51-5

16666

Ursodeoxycholic acid

Approved, Investigational

Phase 2

128-13-2

31401

Neostigmine

Approved, Vet_approved

Phase 1, Phase 2

59-99-4

4456

Pancrelipase

Approved, Investigational

Phase 2,Phase 1

53608-75-6

pancreatin

Phase 2,Phase 1

Bilirubin

Phase 2,Phase 1

635-65-4

5280352

Cholagogues and Choleretics

Phase 2

Cholinergic Agents

Phase 1, Phase 2

Cholinesterase Inhibitors

Phase 1, Phase 2

Gastrointestinal Agents

Phase 2

Neurotransmitter Agents

Phase 1, Phase 2,Not Applicable

Interventional clinical trials:

(show top 50) (show all 60)

#	Name	Status	NCT ID	Phase	Drugs
1	Randomised Trial Comparing Metal and Plastic Biliary Stents Stents for Palliating Malignant Jaundice	Unknown status	NCT00731419	Phase 4
2	Human Kidney Histopathology in Obstructive Jaundice	Completed	NCT01090193	Phase 4
3	Covered vs. Uncovered SEMS for Occluded Biliary Metal Stents	Completed	NCT01315522	Phase 4
4	Antibiotics to Decrease Post ERCP Cholangitis	Recruiting	NCT03087656	Phase 4	Ceftriaxone;Levofloxacin
5	Preoperative Biliary Drainage for the Lower Malignant Obstructive Jaundice	Unknown status	NCT01744938	Phase 3
6	Palliative Biliary Stenting on the Quality of Life of Patients With Unresectable Carcinoma Gallbladder With Hiliar Block.	Completed	NCT00391183	Phase 2, Phase 3
7	A Clinical Trial to Assess the Efficacy and Safety of MK-0653C in Japanese Participants With Hypercholesterolemia (MK-0653C-383)	Completed	NCT02550288	Phase 3	Ezetimibe 10 mg;Atorvastatin 10 mg;Placebo for Ezetimibe 10 mg tablet;Placebo for Atorvastatin 10 mg capsule
8	A Clinical Trial to Assess the Long Term Safety and Tolerability of MK-0653C in Japanese Participants With Hypercholesterolemia (MK-0653C-384)	Completed	NCT02460159	Phase 3	EZ 10 mg/Atorva 20 mg FDC;EZ 10 mg/Atorva 10 mg FDC
9	A Study of the Efficacy and Safety of MK-0653H in Japanese Participants With Hypercholesterolemia (MK-0653H-832)	Completed	NCT02741245	Phase 3	Ezetimibe 10 mg;Rosuvastatin 2.5 mg;Placebo for Ezetimibe;Placebo for Rosuvastatin
10	MK-0524B Lipid Study (MK-0524B-063)	Completed	NCT00479882	Phase 3	Comparator: simvastatin;MK-0524A;Placebo;MK-0524B
11	Lipid Efficacy and Safety in Participants With Mixed Hyperlipidemia (MK-0524B-024)	Completed	NCT00289900	Phase 3	MK-0524A;Atorvastatin;Simvastatin
12	Photodynamic Therapy (PDT) for Palliation of Cholangiocarcinoma	Recruiting	NCT01755013	Phase 2, Phase 3
13	Remaxol® in Mechanical Jaundice of Non-malignant Origin	Active, not recruiting	NCT03418935	Phase 3	Remaxol (succinate + methionine + inosine + nicotinamide);Ringer's Solution
14	Remaxol® in Malignant Mechanical Jaundice	Active, not recruiting	NCT03416062	Phase 3	Remaxol®;Ringer's Solution
15	A Study to Evaluate Efficacy and Safety of Extended-Release Niacin + Laropiprant + Simvastatin in Participants With Primary Hypercholesterolemia or Mixed Dyslipidemia (MK-0524B-118)	Terminated	NCT01294683	Phase 3	Simvastatin;Extended Release (ER) niacin/laropiprant/simvastatin (N/LRPT/SIM);Extended Release (ER) niacin/laropiprant (N/LRPT);Placebo
16	Comparison Between Two Methods of Bilateral Stenting for Malignant Hilar Obstruction	Withdrawn	NCT01622803	Phase 3
17	The Effect of Ursodeoxycholic Acid in Liver Functional Restoration of Patients With Obstructive Jaundice	Unknown status	NCT01688375	Phase 2	Ursodeoxycholic Acid
18	Role of Endoscopic RFA in Prolonging the Patency of Metal Stents in Patients With Malignant Obstructive Jaundice	Unknown status	NCT01275768	Phase 1, Phase 2
19	Cholinergic Anti-inflammatory Pathway in Prevention & Treatment of the SIRS in Patients With Jaundice After Operation.	Unknown status	NCT02279147	Phase 1, Phase 2	neostigmine methylsulfate，raceanisodamine hydrochloride
20	Evaluation of Preoperative Biliary Drainage Before Pancreatoduodenectomy	Unknown status	NCT01941342	Phase 2
21	Metal or Plastic Stents to Relieve Obstruction of Obstructive Jaundice Prior to Resection of Periampullary Tumors.	Completed	NCT02166840	Phase 2
22	Radiofrequency Ablation for Biliopancreatic Malignancy	Completed	NCT02468076	Phase 2
23	SMOFlipid to Lessen the Severity of Neonatal Cholestasis	Terminated	NCT02721277	Phase 1, Phase 2	SMOFlipid
24	C-VISA BikDD: Liposome in Advanced Pancreatic Cancer	Withdrawn	NCT00968604	Phase 1
25	Immune Function in Patients With Obstructive Jaundice	Unknown status	NCT01367821
26	Percutaneous Transhepatic Cholangiography Versus Endoscopic Ultrasound Guided Biliary Drainage	Unknown status	NCT01686425	Not Applicable
27	Efficacy and Safety of Endobiliary Radiofrequency Ablation by Using a Novel RF Catheter (ELRA®) on Maintaining the Patency of Endobiliary Metal Drainage in Patients With Malignant Biliary Strictures : A Double-arm Comparable Study	Unknown status	NCT02646514	Not Applicable
28	Intra-luminal Radiofrequency Ablation for Inoperable Malignant Biliary Stenosis	Unknown status	NCT02841800	Not Applicable
29	Evaluation of Immune Function in Biliary Atresia Children With Prolonged Jaundice	Unknown status	NCT00155194
30	Application of n-3 Fatty to Patient of Jaundice	Completed	NCT03376945		trail cohort;control cohort
31	Comparison Between Internal and External Preoperative Biliary Drainage in Periampullary Cancers	Completed	NCT01134276	Not Applicable
32	Safety and Efficacy of Photodynamic Therapy for Bile Duct Invasion of Hepatocellular Carcinoma	Completed	NCT01506115	Not Applicable	Photofrin
33	Endoscopic Versus Percutaneous Drainage For Hilar Block in Gall Bladder Cancer	Completed	NCT00409864	Not Applicable
34	Outcome of Carbon Dioxide Versus Air Insufflations During Endoscopic Retrograde Cholangiopancreatography (ERCP)	Completed	NCT01321203
35	Endoscopic Ultrasound-guided Biliary Drainage for Malignant Biliary Obstruction After Failed ERCP	Completed	NCT03510754
36	Malignant Obstruction ZILVER Against Routine Therapy (MOZART I)	Completed	NCT00196105	Not Applicable
37	Biliary Atresia, Hepatic Buffer Response and Sevoflurane	Completed	NCT02471209		Sevoflurane
38	Early Versus Late Cholecystectomy After Clearance of Common Bile Duct Stones	Completed	NCT02460315	Not Applicable
39	Endoscopic Retrograde Cholangiopancreatography (ERCP) Based Sampling of Indeterminate Bile Duct Strictures	Completed	NCT01580709	Not Applicable
40	Biliary Cannulation During Endoscopic Retrograde Cholangiopancreatography: Precut Versus Conventional Cannulation	Completed	NCT02477228	Not Applicable
41	Treatment of Obstructive Jaundice in Autoimmune Pancreatitis and/or Immunoglobulin G4-related Sclerosing Cholangitis by Corticosteroids	Recruiting	NCT02797665	Not Applicable	corticosteroids
42	Pre-treatment With Methylene Blue Prevent Peri-operative Reduced Systemic Vascular Resistance	Recruiting	NCT03406676	Not Applicable	Methylene Blue
43	EUS Evaluation of CBD Diameter in Malignant Obstructive Jaundice	Recruiting	NCT03494023
44	Comparison of Metal and Plastic Stents for Preoperative Biliary Decompression	Recruiting	NCT01191814	Not Applicable
45	Cholangioscopic Assessment of Occluded Biliary Stent and Role of Biliary Radiofrequency Ablation	Recruiting	NCT03133026	Not Applicable
46	Trial Comparing Metal Versus Plastic Stents for Preoperative Biliary Decompression	Recruiting	NCT01675908	Not Applicable
47	Efficacy of Partial Covered Double Bare Metal Stent Compared to Uncovered Double Bare Metal Stent in Malignant Biliary Obstruction	Recruiting	NCT02937246	Not Applicable
48	RFA RCT for Pancreatic or Bile Duct Cancer	Recruiting	NCT02166190	Not Applicable
49	Study of Abdominal Drainage in LCBDE+PC	Recruiting	NCT03120754	Not Applicable
50	The Necessity of Bile Cultures in Patients With Acute Cholangitis	Recruiting	NCT02601417	Not Applicable

Search NIH Clinical Center for Obstructive Jaundice

Cochrane evidence based reviews: jaundice, obstructive

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Genetic Tests for Obstructive Jaundice

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Anatomical Context for Obstructive Jaundice

MalaCards organs/tissues related to Obstructive Jaundice:

⁴¹

Liver, Pancreas, Lung, Kidney, Brain, Lymph Node, Myeloid

Sources

Publications for Obstructive Jaundice

Articles related to Obstructive Jaundice:

(show top 50) (show all 767)

#	Title	Authors	Year
1	A Case of Eosinophilic Gastroenteritis in Which Obstructive Jaundice Developed due to Invagination of the Duodenal Wall. ( 29434146 )	Hamamoto H....Ido A.	2018
2	Obstructive jaundice as primary presentation of a stage IIE Non-Hodgkin lymphoma: A decision making process between advanced lymphoma and locally advanced/metastatic pancreatic adenocarcinoma. ( 29547849 )	Blouhos K....Hatzigeorgiadis A.	2018
3	Efficacy of<sup>125</sup>I Versus Non-<sup>125</sup>I Combined with Transcatheter Arterial Chemoembolization for the Treatment of Unresectable Hepatocellular Carcinoma with Obstructive Jaundice. ( 29305738 )	Li S....Wang W.	2018
4	A Surgically Resected Pancreatic Schwannoma with Obstructive Jaundice with Special Reference to Differential Diagnosis from Other Cystic Lesions in the Pancreas. ( 29606941 )	Watanabe T....Shirabe K.	2018
5	Hepatobiliary and Pancreatic: Rare cause of obstructive jaundice by Trichosporon asahii. ( 29372610 )	Zhang L.H....Tang C.W.	2018
6	A Systematic Review and Meta-analysis of Intraluminal Brachytherapy Versus Stent Alone in the Treatment of Malignant Obstructive Jaundice. ( 29075881 )	Xu X....Ji W.	2018
7	A patient with abdominal pain and obstructive jaundice. ( 29749334 )	Dindar G....Turgut H.T.	2018
8	Post-operative care of interventional therapy for 40 liver cancer patients with obstructive jaundice. ( 29767833 )	Tong D.P....Li Y.	2018
9	Elevated endogenous opioids in obstructive jaundice: The possible skin mechanisms. ( 29857894 )	Li X....Tao K.	2018
10	MicroRNA-29a mitigation of endoplasmic reticulum and autophagy aberrance counteracts in obstructive jaundice-induced fibrosis in mice. ( 29105510 )	Huang Y.H....Wang F.S.	2018
11	Spontaneous remission of obstructive jaundice in rats: Selection of experimental models. ( 29904412 )	Lv Y....Li Y.	2018
12	Pancreatic Burkitt's lymphoma presenting as an unusual cause of obstructive jaundice. ( 29696783 )	Yoshizawa N....Takei Y.	2018
13	Bile and circulating HMGB1 contributes to systemic inflammation in obstructive jaundice. ( 29907203 )	Yang R....Tonnessen T.I.	2018
14	Obstructive jaundice caused by an adenoma of the common hepatic duct. ( 29980303 )	Curieses Luengo M....A8lvarez A8lvarez A.	2018
15	MicroRNA-29a mitigation of toll-like receptor 2 and 4 signaling and alleviation of obstructive jaundice-induced fibrosis in mice. ( 29366780 )	Lin Y.C....Huang Y.H.	2018
16	Combined Effectiveness of Honey and Immunonutrition on Bacterial Translocation Secondary to Obstructive Jaundice in Rats: Experimental Study. ( 29786675 )	Oguz S....Erenoglu C.	2018
17	Primary pancreatic lymphoma as a cause of obstructive jaundice. ( 29615287 )	RodrA-guez-Infante A....GarcA-a-FlA^rez L.J.	2018
18	Pancreatobiliary fistula associated with intraductal papillary mucinous carcinoma accompanying obstructive jaundice: A case report. ( 29890488 )	Komo T....Hirabayashi N.	2018
19	The Effect of Calcium Dobesilate on Liver Damage in Experimental Obstructive Jaundice. ( 29589984 )	Unal Y....Hucumenoglu S.	2018
20	Duodenal mucinous adenocarcinoma presenting as ileus, obstructive jaundice and massive ascites: A case report. ( 29456851 )	Ding D....Zhang S.	2018
21	Malignant obstructive jaundice treated with intraluminal placement of Iodine-125 seed strands and metal stents: An analysis of long-term outcomes and prognostic features. ( 29748084 )	Ma J....Yan Z.	2018
22	Spironolactone rescues renal dysfunction in obstructive jaundice rats by upregulating ACE2 expression. ( 29882088 )	Kong E.L....Wu F.X.	2018
23	Comparison of Endoscopic Ultrasonography Guided Biliary Drainage and Percutaneous Transhepatic Biliary Drainage in the Management of Malignant Obstructive Jaundice After Failed ERCP: Erratum. ( 29613967 )		2018
24	Pathophysiological consequences of obstructive jaundice and perioperative management. ( 29428098 )	Pavlidis E.T....Pavlidis T.E.	2018
25	Identification of bile survivin and carbohydrate antigen 199 in distinguishing cholangiocarcinoma from benign obstructive jaundice. ( 27874286 )	Liu Y....Zhang Z.	2017
26	Magnetic Resonance Cholangiopancreatography (MRCP) Evaluation of Obstructive Jaundice in Comparison with Endoscopic Retrograde Cholangiopancreatography (ERCP). ( 28588181 )	Imam S....Akhter P.	2017
27	Cholangiohydatidosis: an Infrequent Cause of Obstructive Jaundice and Acute Cholangitis. ( 28425414 )	Manterola C....Otzen T.	2017
28	An HIV-positive Case of Obstructive Jaundice Caused by Immune Reconstitution Inflammatory Syndrome of Tuberculous Lymphadenitis Successfully Treated with Corticosteroids. ( 28883243 )	Watanabe N....Ohta K.	2017
29	Comparison of Endoscopic Ultrasonography Guided Biliary Drainage and Percutaneous Transhepatic Biliary Drainage in the Management of Malignant Obstructive Jaundice After Failed ERCP. ( 29206804 )	Huang P....Lou S.	2017
30	Von Meyenburg complexes in a patient with obstructive jaundice. ( 28899322 )	Gupta V....Makharia G.	2017
31	Pseudohyponatraemia secondary to hyperlipidaemia in obstructive jaundice. ( 29196308 )	Igbinedion S.O....Boktor M.	2017
32	Clinical Study on Using (125)I Seeds Articles Combined with Biliary Stent Implantation in the Treatment of Malignant Obstructive Jaundice. ( 28739766 )	Wang T....Wang L.G.	2017
33	A new intraductal radiofrequency ablation device for inoperable biliopancreatic tumors complicated by obstructive jaundice: the IGNITE-1 study. ( 28732391 )	Laleman W....Verslype C.	2017
34	A simple rat model of in situ reversible obstructive jaundice in situ reversible obstructive jaundice model. ( 28580342 )	Huang X....Dong J.H.	2017
35	Clinical Interpretation of Elevated CA 19-9 Levels in Obstructive Jaundice Following Benign and Malignant Pancreatobiliary Disease. ( 28830135 )	Kim M.S....Kim Y.M.	2017
36	Embryonal rhabdomyosarcoma of the biliary tree: A rare cause of obstructive jaundice in children which can mimic choledochal cysts. ( 29089679 )	Kinariwala D.J....McCullough W.P.	2017
37	Lemmel's syndrome: Obstructive jaundice secondary to a duodenal diverticulum. ( 28341217 )	Carmona AgA_ndez M....Blanco FernA!ndez G.	2017
38	Primary extrahepatic bile duct neuroendocrine tumor with obstructive jaundice masquerading as a Klatskin tumor. ( 28596824 )	Hoepfner L....White J.A.	2017
39	A late unusual complication after an open cholecystectomy: Amputation neuroma of the CBD causing obstructive jaundice. ( 28837915 )	Sleiman Y.A....Allouch M.	2017
40	Altered expression of differential gene and lncRNA in the lower thoracic spinal cord on different time courses of experimental obstructive jaundice model accompanied with altered peripheral nociception in rats. ( 29285317 )	Wang Q....Xiang H.B.	2017
41	Obstructive Jaundice Caused by Hepatic Torsion in an Infant with Congenital Diaphragmatic Hernia. ( 28082781 )	Jan I.A....Mussa A.B.	2017
42	Endoscopic ultrasound-guided choledochoduodenostomy for obstructive jaundice with venous collaterals around the bile duct wall (with video). ( 28440241 )	Ogura T....Higuchi K.	2017
43	Fine-needle aspiration findings of a rare hematopoietic neoplasm presenting as obstructive jaundice. ( 28752676 )	Tracht J....Rosenblum Donath F.	2017
44	Comparison of efficacy and complications of endoscopic and percutaneous biliary drainage in malignant obstructive jaundice: a systematic review and meta-analysis. ( 29037223 )	Duan F....Liu X.	2017
45	Preventing oxygen free radical damage by proanthocyanidin in obstructive jaundice. ( 28740952 )	Savdan M....TavlA+ A.9.	2017
46	Autoimmune Hemolytic Anemia Obscured by the Obstructive Jaundice Associated with IgG4-related Sclerosing Cholangitis in a Patient with Type 1 Autoimmune Pancreatitis: A Case Report and Review of the Literature. ( 29269682 )	Yoshida M....Joh T.	2017
47	Effects of Different Palliative Jaundice Reducing Methods on Immunologic Functions in Patients with Advanced Malignant Obstructive Jaundice. ( 28739769 )	Tang K....Liu X.F.	2017
48	Advanced Roux-en-Y hepaticojejunostomy with magnetic compressive anastomats in obstructive jaundice dog models. ( 28779259 )	Fan C....Lv Y.	2017
49	Obstructive Jaundice Caused by Heterotopic Pancreas. ( 29215624 )	Li Y....Nie Y.	2017
50	My First Patient: More Than Obstructive Jaundice. ( 28027099 )	Holton-Burke R.C....Stewart D.	2017

Sources

Genes for Obstructive Jaundice

Genes related to Obstructive Jaundice (0 elite genes):

(show all 16)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	ALPP	Alkaline Phosphatase, Placental	Protein Coding	29.98	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	15625352 1995758 15813880
2	GPT	Glutamic--Pyruvic Transaminase	Protein Coding	25.43	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	1721943
3	SLC25A13	Solute Carrier Family 25 Member 13	Protein Coding	25.24	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : DISEASES inferred (show sections)	12692712 11343052
4	TTR	Transthyretin	Protein Coding	24.01	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	11702667
5	ALB	Albumin	Protein Coding	23.7	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
6	GGT1	Gamma-Glutamyltransferase 1	Protein Coding	23.22	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	18773671 19143075
7	IL6	Interleukin 6	Protein Coding	22.63	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
8	TNF	Tumor Necrosis Factor	Protein Coding	22.49	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
9	F2	Coagulation Factor II, Thrombin	Protein Coding	22.37	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
10	SLC17A5	Solute Carrier Family 17 Member 5	Protein Coding	21.86	Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	15625352 2342668
11	CD79A	CD79a Molecule	Protein Coding	21.86	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
12	EDN1	Endothelin 1	Protein Coding	21.19	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
13	REN	Renin	Protein Coding	20.97	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
14	HGF	Hepatocyte Growth Factor	Protein Coding	20.91	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
15	GPBAR1	G Protein-Coupled Bile Acid Receptor 1	Protein Coding	20.87	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
16	CXCL8	C-X-C Motif Chemokine Ligand 8	Protein Coding	20.72	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)

Sources

Variations for Obstructive Jaundice

Sources

Expression for Obstructive Jaundice

Search GEO for disease gene expression data for Obstructive Jaundice.

Sources

Pathways for Obstructive Jaundice

Pathways related to Obstructive Jaundice according to GeneCards Suite gene sharing:

(show all 18)

#	Super pathways	Score	Top Affiliating Genes
1	IL-1 Family Signaling Pathways ⁶⁵ Show member pathways Immune response IL-1 signaling pathway ²² Mucin expression in CF via TLRs, EGFR signaling pathways ²²	12.02	CXCL8 EDN1 IL6 TNF
2	Folate Metabolism ¹ Show member pathways Selenium Micronutrient Network ¹ thioredoxin pathway ¹ Vitamin B12 Metabolism ¹	11.89	ALB F2 GGT1 IL6 TNF
3	Spinal Cord Injury ¹	11.83	CXCL8 IL6 TNF
4	Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁵	11.83	ALB ALPP HGF IL6
5	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁵	11.81	CD79A IL6 TNF
6	TNF signaling pathway ³⁷	11.77	EDN1 IL6 TNF
7	Interleukin-4 and 13 signaling ⁶⁶	11.73	CXCL8 HGF IL6 TNF
8	Amoebiasis ³⁷	11.71	CXCL8 IL6 TNF
9	Rheumatoid arthritis ³⁷	11.67	CXCL8 IL6 TNF
10	AGE-RAGE signaling pathway in diabetic complications ³⁷	11.62	CXCL8 EDN1 IL6 TNF
11	Pertussis ³⁷	11.58	CXCL8 IL6 TNF
12	Photodynamic therapy-induced NF-kB survival signaling ¹ Show member pathways Immune response MIF-mediated glucocorticoid regulation ²²	11.49	CXCL8 IL6 TNF
13	Legionellosis ³⁷	11.41	CXCL8 IL6 TNF
14	Interleukin-10 signaling ⁶⁶	11.32	CXCL8 IL6 TNF
15	FOXA2 and FOXA3 transcription factor networks ¹	11.25	ALB F2 TTR
16	Malaria ³⁷	10.95	CXCL8 HGF IL6 TNF
17	Lung fibrosis ¹	10.82	CXCL8 EDN1 HGF IL6 TNF
18	Overview of nanoparticle effects ¹	10.71	CXCL8 IL6 TNF

Sources

GO Terms for Obstructive Jaundice

Cellular components related to Obstructive Jaundice according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:0005576	9.61	ALB CXCL8 EDN1 F2 HGF IL6
2	extracellular space	GO:0005615	9.36	ALB CXCL8 EDN1 F2 GGT1 GPT

Biological processes related to Obstructive Jaundice according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cytokine-mediated signaling pathway	GO:0019221	9.62	CXCL8 HGF IL6 TNF
2	positive regulation of DNA binding transcription factor activity	GO:0051091	9.54	EDN1 IL6 TNF
3	cellular protein metabolic process	GO:0044267	9.46	ALB F2 IL6 TTR
4	embryonic digestive tract development	GO:0048566	9.4	CXCL8 TNF
5	negative regulation of lipid storage	GO:0010888	9.26	IL6 TNF
6	regulation of signaling receptor activity	GO:0010469	9.17	CXCL8 EDN1 F2 HGF IL6 TNF
7	positive regulation of smooth muscle cell proliferation	GO:0048661	9.13	EDN1 IL6 TNF

Molecular functions related to Obstructive Jaundice according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cytokine activity	GO:0005125	8.92	CXCL8 EDN1 IL6 TNF

Sources

Sources for Obstructive Jaundice

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia