Obstructive Jaundice disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: OBS001 MIFTS: 43	Obstructive Jaundice Categories: Gastrointestinal diseases, Genetic diseases	Data Licensing For inquiries, contact: [email protected]
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Aliases & Classifications for Obstructive Jaundice

MalaCards integrated aliases for Obstructive Jaundice:

Name: Obstructive Jaundice ¹¹ ¹⁴ ¹⁶

Jaundice, Obstructive ⁴³ ⁷¹

Obstructive Hyperbilirubinemia ¹¹

Cholestatic Jaundice Syndrome ¹¹

Cholestatic Jaundice ¹¹

Jaundice Obstructive ⁵³

Jaundice Cholestatic ⁵³

Classifications:

MalaCards categories:
Global: Genetic diseases
Anatomical: Gastrointestinal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:13603

MeSH ⁴³ D041781

NCIt ⁴⁹ C34742

SNOMED-CT ⁶⁸ 59848001

EFO ¹⁶ EFO_1001068

UMLS ⁷¹ C0022354

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Summaries for Obstructive Jaundice

Disease Ontology: ¹¹ A cholestasis characterized by yellowish pigmentation of the skin and sclera due to high bilirubin levels resulting from biliary tract obstruction.

MalaCards based summary: Obstructive Jaundice, also known as jaundice, obstructive, is related to cholestasis and cholangiocarcinoma, and has symptoms including icterus and jaundice (not of newborn). An important gene associated with Obstructive Jaundice is ALPP (Alkaline Phosphatase, Placental), and among its related pathways/superpathways is FOXA2 and FOXA3 transcription factor networks. The drugs Lactulose and Nicotinamide have been mentioned in the context of this disorder. Affiliated tissues include liver, skin and pancreas, and related phenotypes are renal/urinary system and homeostasis/metabolism

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Related Diseases for Obstructive Jaundice

Diseases in the Obstructive Jaundice family:

Jaundice, Familial Obstructive, of Infancy

Diseases related to Obstructive Jaundice via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1069)

#	Related Disease	Score	Top Affiliating Genes
1	cholestasis	32.6	SLC25A13 SLC17A5 GPT GGT1 F2 CCK
2	cholangiocarcinoma	31.4	KRT7 GGT1 CEACAM5 AFP
3	hemochromatosis, neonatal	31.3	SLC25A13 SLC17A5 GGT1
4	acute kidney failure	31.2	GPT F2 ALB
5	pancreatitis	31.1	SERPINA3 GGT1 CRP CCK ALB
6	cholelithiasis	31.1	GPT CRP CCK ALB
7	cholecystitis	31.0	GPT F2 CRP CCK ALB
8	cholangitis	30.9	KRT7 GPT GGT1 F2 CRP CEACAM5
9	bile duct cysts	30.8	KRT7 GPT CEACAM5 ALB AFP
10	hyperthyroidism	30.8	GPT F2 CRP ALB
11	biliary atresia	30.8	KRT7 GPT GGT1 F2 ALB
12	ovarian serous cystadenocarcinoma	30.8	SERPINA3 MUC16 CEACAM5
13	portal hypertension	30.8	SLC17A5 GPT GGT1 F2 ALB AFP
14	bile duct cancer	30.8	KRT7 GPT CEACAM5 ALB AFP
15	cystadenoma	30.7	SERPINA3 MUC16 KRT7 CEACAM5 AFP
16	exanthem	30.7	GPT F2 CRP ALB
17	amyloidosis	30.7	TTR SERPINA3 CRP ALB
18	disseminated intravascular coagulation	30.7	GPT F2 CRP
19	gallbladder cancer	30.7	MUC16 KRT7 GPT CEACAM5 ALB AFP
20	acute cholangitis	30.7	GPT F2 CRP CEACAM5 ALB
21	peritonitis	30.7	MUC16 F2 CRP ALB
22	lymph node tuberculosis	30.6	CRP ALB
23	choledocholithiasis	30.6	SLC17A5 GPT GGT1 F2 CRP CEACAM5
24	appendix adenocarcinoma	30.6	KRT7 CEACAM5
25	fascioliasis	30.6	SLC17A5 GPT GGT1 ALPP ALB
26	acute kidney tubular necrosis	30.5	GPT CRP ALB
27	kidney disease	30.5	TTR LCAT GGT1 F2 CRP ALB
28	suppurative cholangitis	30.5	GPT F2 CRP ALB
29	klatskin's tumor	30.5	KRT7 GPT F2 CEACAM5 ALB AFP
30	aortic aneurysm, familial abdominal, 1	30.5	SERPINA3 MIR122 CRP ALB
31	hepatorenal syndrome	30.5	GPT F2 ALB AFP
32	duodenal obstruction	30.5	GPT CRP CEACAM5 CCK ALB
33	sclerosing cholangitis	30.5	GPT F2 CRP ALB AFP
34	viral infectious disease	30.5	SLC17A5 SERPINA3 MIR122 GPT
35	portal vein thrombosis	30.5	GPT F2 CRP ALB AFP
36	hepatic encephalopathy	30.5	TTR SLC25A13 SLC17A5 GPT F2 ALB
37	miliary tuberculosis	30.5	GPT CRP ALB
38	duodenitis	30.5	CRP CCK ALB
39	ascending cholangitis	30.4	GPT F2 CRP ALB
40	bilirubin metabolic disorder	30.4	SLC25A13 SLC17A5 GPT GGT1 F2 CRP
41	xanthogranulomatous cholecystitis	30.4	SERPINA3 CEACAM5
42	cystadenocarcinoma	30.4	SERPINA3 MUC16 KRT7 CEACAM5 ALPP
43	pancreatic cancer	30.4	SERPINA3 PSG2 MUC16 KRT7 GPT GGT1
44	hypercholesterolemia, familial, 1	30.4	LCAT GPT GHR CRP
45	cavernous hemangioma	30.4	SERPINA3 F2 CEACAM5 ALB AFP
46	intrahepatic cholestasis	30.4	SLC25A13 SLC17A5 GPT GGT1 ALPP ALB
47	viral hepatitis	30.4	SLC17A5 MIR122 GPT GGT1 F2 CRP
48	autoimmune hepatitis	30.4	SLC17A5 GPT GGT1 F2 ALB
49	hydrops of gallbladder	30.3	GPT CRP ALB
50	superior mesenteric artery syndrome	30.3	CRP ALB

Graphical network of the top 20 diseases related to Obstructive Jaundice:

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Symptoms & Phenotypes for Obstructive Jaundice

UMLS symptoms related to Obstructive Jaundice:

icterus; jaundice (not of newborn)

MGI Mouse Phenotypes related to Obstructive Jaundice:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	renal/urinary system	MP:0005367	9.56	ALB CCK GGT1 GHR KRT7 LCAT
2	homeostasis/metabolism	MP:0005376	9.53	AFP ALB BLVRB CCK CEACAM5 CRP

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Drugs & Therapeutics for Obstructive Jaundice

Drugs for Obstructive Jaundice (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 55)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Lactulose

Approved

Phase 4

4618-18-2

11333

Nicotinamide

Approved, Investigational

Phase 3

98-92-0

936

Folic acid

Approved, Nutraceutical, Vet_approved

Phase 3

59-30-3

6037

Niacin

Approved, Investigational, Nutraceutical

Phase 3

59-67-6

938

Racemethionine

Approved, Experimental, Investigational, Nutraceutical

Phase 3

59-51-8, 63-68-3, 348-67-4

6137

Vitamins

Phase 3

Pharmaceutical Solutions

Phase 3

Folate

Phase 3

Vitamin B9

Phase 3

Vitamin B3

Phase 3

Trace Elements

Phase 3

Nicotinic Acids

Phase 3

Antimetabolites

Phase 3

Vasodilator Agents

Phase 3

Vitamin B Complex

Phase 3

Hypolipidemic Agents

Phase 3

Lipid Regulating Agents

Phase 3

Micronutrients

Phase 3

Ursodeoxycholic acid

Approved, Investigational

Phase 2

128-13-2

31401

Neostigmine

Approved, Vet_approved

Phase 1, Phase 2

59-99-4

4456 5824

Gastrointestinal Agents

Phase 2

Neurotransmitter Agents

Phase 1, Phase 2

Anti-Inflammatory Agents

Phase 1, Phase 2

Cholinesterase Inhibitors

Phase 1, Phase 2

Cholinergic Agents

Phase 1, Phase 2

Liver Extracts

Phase 1, Phase 2

Omega 3 Fatty Acid

Phase 1, Phase 2

Parenteral Nutrition Solutions

Phase 1, Phase 2

bilirubin

Phase 1, Phase 2

635-65-4

5280352

SMOFlipid

Phase 1, Phase 2

Fat Emulsions, Intravenous

Phase 1, Phase 2

Soy Bean

Phase 1, Phase 2

Olive

Phase 1, Phase 2

Norepinephrine

Approved

Phase 1

51-41-2

439260

Methylene blue

Approved, Investigational

Phase 1

61-73-4

6099

Prednisone

Approved, Vet_approved

53-03-2

5865

Pancrelipase

Approved, Investigational

53608-75-6

8519

Trioxsalen

Approved

3902-71-4

5585

Ceftriaxone

Approved

73384-59-5

5479530

Dihematoporphyrin ether

Investigational

97067-70-4

Diethyl ether

Experimental

60-29-7

3283

Immunoglobulins, Intravenous

Immunoglobulins

Immunoglobulin G

Antibodies

Pancreatin

Photosensitizing Agents

Hematoporphyrins

Hematoporphyrin Derivative

Dermatologic Agents

Interventional clinical trials:

(show all 45)

#	Name	Status	NCT ID	Phase	Drugs
1	Phase 4 Study :Human Kidney Histopathology in Acute Obstructive Jaundice: a Prospective Study	Completed	NCT01090193	Phase 4
2	Re-intervention for Occluded Biliary Metal Stent in Malignant Distal Bile Duct Obstruction: a Prospective Randomized Multi-center Trial Comparing Covered and Uncovered Metal Stent	Completed	NCT01315522	Phase 4
3	Preoperative Biliary Drainage for the Lower Malignant Obstructive Jaundice: A Phase III, Randomized, Controlled, Single Center Study.	Unknown status	NCT01744938	Phase 3
4	A Multicenter, Double-Blind, Placebo-Controlled, Randomized Trial of Efficacy and Safety of Remaxol®, a Solution for Intravenous Infusions Produced by STPF "POLYSAN" (Russia), in Patients With Mechanical Jaundice of Non-Malignant Origin	Completed	NCT03418935	Phase 3	Remaxol (succinate + methionine + inosine + nicotinamide);Ringer's Solution
5	A Multicenter, Double-blind, Placebo-controlled, Randomized Trial of the Efficacy and Safety of Remaxol®, a Solution for Infusions Produced by STPF POLYSAN (Russia), in Patients With Malignant Mechanical Jaundice	Completed	NCT03416062	Phase 3	Remaxol®;Ringer's Solution
6	Comparison Between Two Methods of Bilateral Stenting for Malignant Hilar Obstruction	Withdrawn	NCT01622803	Phase 3
7	The Effect of Ursodeoxycholic Acid in Liver Functional Restoration of Patients With Obstructive Jaundice After Endoscopic or Surgical Treatment	Unknown status	NCT01688375	Phase 2	Ursodeoxycholic Acid
8	A Double Blind, Randomized Controlled Prospective Trial of Endo-biliary Radio-frequency Ablation for Maintenance of Metal Stent Patency in Patients With Malignant Obstructive Jaundice	Unknown status	NCT01275768	Phase 1, Phase 2
9	The Prevention and Treatment of SIRS in Patients With Cholestatic Jaundice After Operation.	Unknown status	NCT02279147	Phase 1, Phase 2	neostigmine methylsulfate，raceanisodamine hydrochloride
10	Investigation of the Effect of Intraductal Radiofrequency Ablation in Inoperable Biliopancreatic Tumors Complicated With Obstructive Jaundice	Completed	NCT02468076	Phase 2
11	Self Expanding Metal Stents (SEMS) or Plastic Stents to Relieve Obstruction of Obstructive Jaundice Prior to Resection of Periampullary Tumors.	Completed	NCT02166840	Phase 2
12	Compassionate Use of an Intravenous Fat Emulsion Comprised of Soy Oil, Medium Chain Triglycerides, Olive Oil, and Fish Oil for Neonates With Parenteral Nutrition Induced Liver Injury	Terminated	NCT02721277	Phase 1, Phase 2	SMOFlipid
13	Effect of Methylene Blue on Perioperative Organ Function in Patients With Obstructive Jaundice	Unknown status	NCT04109859	Phase 1	Saline;Methylene Blue
14	Treatment of Obstructive Jaundice in Autoimmune Pancreatitis and/or Immunoglobulin G4-related Sclerosing Cholangitis by Corticosteroids	Unknown status	NCT02797665		corticosteroids
15	Process Optimization of Preoperative Biliary Drainage in Patients With Malignant Obstructive Jaundice of Extrahepatic Bile Duct: A Multi-center, Prospective, Open-labeled, Real World Study Based on Electronic Data Capture System	Unknown status	NCT03527875
16	The Preventive Effects of Pre-treatment With Methylene Blue for Vascular Paralysis of the Patients With Obstructive Jaundice During Operation	Unknown status	NCT03406676		Methylene Blue
17	Quorum Sensing Signal Molecules (QSSMs) and Immune Dysfunction in Patients Undergoing Endoscopic Retrograde Cholangiopancreatography (ERCP) for Obstructive Jaundice	Unknown status	NCT01367821
18	A Multisite, Open-label, Prospective Cohort Study Investigating Huaier Granule Combined With Biliary Drainage for Treatment of Malignant Obstructive Jaundice（MOJ）	Unknown status	NCT03491254
19	The Role of Cholangioscopy and Biliary Radio Frequency Ablation in the Management of Occluded Biliary Self-expanding Metal Stent.	Unknown status	NCT03133026
20	A Randomized Trial Comparing Covered Metal and Plastic Stents for Preoperative Biliary Decompression in Pancreatic Cancer	Unknown status	NCT01191814
21	Endoscopic Retrograde Cholangiopancreatography, Endoscopic Ultrasound and Interventional Endoscopy in Pancreatico-biliary, Gastrointestinal and Esophageal Disorders	Unknown status	NCT01438385
22	Endoscopic Access Loop With Bilio-enteric Anastomosis: A Prospective Randomized Comparison Between Gastric and Subcutaneous Accesses	Unknown status	NCT03252379
23	Safety and Efficacy of n-3 Fatty Acid-based Parenteral Nutrition in Patients With Obstructive Jaundice: A Propensity-matched Study	Completed	NCT03376945		trail cohort;control cohort
24	Prospective Study on the Comparison Between the Clinicopathological Outcomes According to the Methods of Preoperative Biliary Drainage in Periampullary Cancers Causing Obstructive Jaundice	Completed	NCT01134276
25	Endoscopic Ultrasound Evaluation of the Common Bile Duct in Patients With Obstructive Jaundice Due to Bilio-pancreatic Malignancies: a Multicenter Prospective Study (ECCO Trial)	Completed	NCT05155475
26	Endoscopic Ultrasound Evaluation of the Common Bile Duct in Patients With Obstructive Jaundice Due to Bilio-Pancreatic Malignancies: A Multicenter Prospective Study	Completed	NCT03494023
27	Endoscopic Versus Percutaneous Biliary Drainage For Hilar Block Due to Carcinoma Gall Bladder: A Randomized Prospective Trial and Quality Of Life Assessment	Completed	NCT00409864
28	The Status of Advanced Endoscopy in the Era of COVID-19: a Multicenter Study	Completed	NCT04385147
29	Multicenter Randomized Trial Comparing Covered Metal and Plastic Stents for Preoperative Biliary Decompression in Pancreatic Cancer	Completed	NCT01675908
30	Endoscopic Versus Percutaneous Biliary Drainage for Resectable Pancreatic Head Cancer With Hyperbilirubinemia and Impact on Pancreaticoduodenectomy: A Prospective Cohort Study	Completed	NCT04823832
31	Endoscopic Ultrasound-guided Biliary Drainage for Malignant Biliary Obstruction After Failed ERCP: a Single Italian Center Experience	Completed	NCT03510754
32	A Double-blind, Randomized, Controlled Trial of Air Insufflation Versus Carbon Dioxide Insufflation During Endoscopic Retrograde Cholangiopancreatography (ERCP).	Completed	NCT01321203
33	Observational Study for Safety and Efficacy of Photodynamic Therapy for Bile Duct Invasion of Hepatocellular Carcinoma	Completed	NCT01506115		Photofrin
34	Multicenter RCT Comparing Two Brushes of Different Diameters for Biliary Stenosis: RX Cytology Brush, BOSTON vs. Infinity® Brush, US Endoscopy. BIB Study (BIliary Brushing)	Completed	NCT04251013
35	Full Data BDI Digestif RSCM	Completed	NCT04582240
36	Biliary Cannulation During Endoscopic Retrograde Cholangiopancreatography: Precut Versus Conventional Cannulation. A Prospective Randomized Study	Completed	NCT02477228
37	Multicenter Prospective Randomized Controlled Trial of the Nitinol ZILVER Expandable Endoprosthesis in the Palliation of Extrahepatic Malignant Biliary Obstruction	Completed	NCT00196105
38	The Influence of Antibiotics on the Incidence of Biliary Tract Infections After PTCD for Malignant Obstructive Jaundice	Recruiting	NCT04620577
39	Role of Ultrasonography as a Single Tool for Guidance of Percutaneous Transhepatic Biliary Drainage in Obstructive Jaundice	Recruiting	NCT05246176
40	Prospective Evaluation of the Use of a Biodegradable Endoprothesis in the Prevention of Post-Endoscopic Retrograde CholoangioPancreatography Pancreatitis	Recruiting	NCT03977779
41	Influence of Percutaneous Biliary Drainage on the Change of Enzyme Activity of Matrix Metalloproteinases in the Serum of Patients With Malignant Obstructive Hyperbilirubinemia	Recruiting	NCT04801914
42	Role of Biodegradable Polydioxanone Biliary Stents for the Percutaneous Treatment of Benign Biliary Strictures.	Active, not recruiting	NCT05556668
43	Comparison of Efficacy and Safety of Endoscopic Biliary Drainage and Percutaneous Transhepatic Biliary Drainage for the Management of Perihilar Malignant Biliary Obstruction: a Monocentric Retrospective Study	Active, not recruiting	NCT05078801
44	preGallstep: One-step Laparoscopic Cholecystectomy, Common Bile Duct Exploration and Stone Extraction Versus Two-step Endoscopic Retrograde Cholangiography and Stone Extraction Plus Laparoscopic Cholecystectomy for Common Bile Duct Stones	Not yet recruiting	NCT04801238
45	Preoperative Endoscopic Biliary Drainage With Self Expanding Metal Stents (SEMS) vs. Direct Surgical Resection for Patients With Severe Obstructive Jaundice	Terminated	NCT03820544

Search NIH Clinical Center for Obstructive Jaundice

Cochrane evidence based reviews: jaundice, obstructive

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Genetic Tests for Obstructive Jaundice

Sources

Anatomical Context for Obstructive Jaundice

Organs/tissues related to Obstructive Jaundice:

MalaCards : Liver, Skin, Pancreas, Kidney, Lymph Node, Neutrophil, Lung

Sources

Publications for Obstructive Jaundice

Articles related to Obstructive Jaundice:

(show top 50) (show all 8864)

#	Title	Authors	PMID	Year
1	[Analysis of tear enzymes in the diagnosis of obstructive jaundice associated with subhepatic cholestasis]. ⁵³ ⁶²	Terekhina NA...Soldatenko NV	19143075	2008
2	Improvement in accuracy of gamma-glutamyl transferase for differential diagnosis of biliary atresia by correlation with age. ⁵³ ⁶²	Rendon-Macias ME...Sandoval-Mex AM	18773671	2008
3	CEA, CA 19-9, and CA 125 in the differential diagnosis of benign and malignant pancreatic diseases with or without jaundice. ⁵³ ⁶²	Duraker N...Urhan N	17262731	2007
4	Autoimmune hepatitis/primary sclerosing cholangitis overlap syndrome in a child: diagnostic usefulness of magnetic resonance cholangiopancreatography. ⁵³ ⁶²	Lee WS...Sarji SA	15813880	2005
5	Contrasting liver function test patterns in obstructive jaundice due to biliary strictures [corrected] and stones. ⁵³ ⁶²	Hayat JO...Gorard DA	15625352	2005
6	A novel inborn error of metabolism detected by elevated methionine and/or galactose in newborn screening: neonatal intrahepatic cholestasis caused by citrin deficiency. ⁵³ ⁶²	Ohura T...Iinuma K	12692712	2003
7	[Clinical study on the changes of growth hormone/insulin-like growth factor-I axis in patient with obstructive jaundice]. ⁵³ ⁶²	An Y...Liu B	11702667	2001
8	Infantile cholestatic jaundice associated with adult-onset type II citrullinemia. ⁵³ ⁶²	Tazawa Y...Saheki T	11343052	2001
9	Factors predicting nutritional derangements in patients with obstructive jaundice: multivariate analysis. ⁵³ ⁶²	Padillo FJ...Pera-Madrazo C	11344390	2001
10	Activity of class I and II isoenzymes of alcohol dehydrogenase measured by a fluorometric method in the sera of patients with obstructive jaundice. ⁵³ ⁶²	Chrostek L...Szmitkowski M	9247733	1997
11	Clinical values of CA19-9, CA125 and CEA in malignant obstructive jaundice. ⁵³ ⁶²	Ng WW...Lee SD	7634181	1995
12	Discrepancies between lipoprotein(a) concentrations in icteric sera measured by immunonephelometry and electroimmunodiffusion. ⁵³ ⁶²	Beaudeux JL...Legrand A	8200119	1994
13	T-lymphocyte transformation in experimental obstructive jaundice: the role of serum-suppressive factors. ⁵³ ⁶²	Thompson RL...Rowlands BJ	8109118	1993
14	Role of endogenous bile on basal and postprandial CCK release in humans. ⁵³ ⁶²	Koide M...Otsuki M	8391974	1993
15	Human lymphocyte responsiveness is not enhanced by relief of biliary obstruction: an in-vitro study. ⁵³ ⁶²	Pace RF...Benjamin IS	2025801	1991
16	Bile acids in human plasma interfere with cholecystokinin bioassay using dispersed pancreatic acini. ⁵³ ⁶²	Miyasaka K...Kitani K	1995267	1991
17	Changes in plasma high density lipoprotein cholesterol and phospholipid in acute viral hepatitis and cholestatic jaundice. ⁵³ ⁶²	Ahaneku JE...Taylor GO	1995758	1991
18	[Reduction of erythrocyte membrane band 4.2 protein in patients with obstructive jaundice]. ⁵³ ⁶²	Inoue F...Tokumine J	2255052	1990
19	A combination of raised serum AST:ALT ratio and erythrocyte mean cell volume level detects excessive alcohol consumption. ⁵³ ⁶²	Kawachi I...Stace NH	2342668	1990
20	A case of obstructive jaundice caused by metastasis of breast cancer to the intra/extrahepatic bile duct. ⁶²	Suzuki Y...Irisawa A	35898837	2023
21	A rare cause of obstructive jaundice in a patient with hepatocellular carcinoma. ⁶²	Ryou SY...Sung PS	35999137	2022
22	A child with pancreatic hemangiomatosis presenting as obstructive jaundice: A rare case report. ⁶²	Wang B...Hao J	35753913	2022
23	Impact of biliary drainage prior to pancreatectomy. ⁶²	Bademci R...Raventos VA	33929304	2022
24	Role of biliary drainage before pancreatoduodenectomy for pancreatic adenocarcinoma: a retrospective study. ⁶²	Scherber PR...Glanemann M	35230040	2022
25	Time progression and regional expression of brain oxidative stress induced by obstructive jaundice in rats. ⁶²	Lilimpakis K...Georgiou CD	36434681	2022
26	A Rare Cause of Obstructive Jaundice. ⁶²	Wu R...Zhang B	36372221	2022
27	Hilar tuberculosis versus Klatskin tumour: a diagnostic challenge. ⁶²	Biswas J...Ray S	36332934	2022
28	A rare synchrony of adenocarcinoma of the ampulla with an ileal gastrointestinal stromal tumor: A case report. ⁶²	Matli VVK...Morris J	36438708	2022
29	Successful Treatment of Pediatric Acute Myeloid Leukemia Presenting with Hyperbilirubinemia Secondary to Myeloid Sarcoma: A Case Report. ⁶²	Shash HA...Khairy AM	36360428	2022
30	Improvement of cholestatic episodes in patients with benign recurrent intrahepatic cholestasis (BRIC) treated with rifampicin. A long-term follow-up. ⁶²	Helgadottir H...Vesterhus M	36369734	2022
31	Conjugated Bile Acids Accelerate Progression of Pancreatic Cancer Metastasis via S1PR2 Signaling in Cholestasis. ⁶²	Sarkar J...Takabe K	36396870	2022
32	Fully covered metal stents vs plastic stents for preoperative biliary drainage in patients with resectable pancreatic cancer without neoadjuvant chemotherapy: A multicenter, prospective, randomized controlled trial. ⁶²	Mandai K...Itoi T	34860467	2022
33	Vater Papilla-preserving Strategy for Advanced Hepatocellular Carcinoma With Excessive Bile Duct Tumor Thrombus. ⁶²	Yamamura K...Isiko T	36288845	2022
34	Left hepatic lobe agenesis, a rare anatomical condition. ⁶²	Gomez Facundo H...Gonzalez Martinez S	35255698	2022
35	Obstructive jaundice secondary to a pseudoaneurysm in anatomical variant of the hepatic artery. ⁶²	Dopazo MS...Carlos Fernandez Fernandez J	36435377	2022
36	EUS-guided hepaticogastrostomy in patients with obstructive jaundice after failed or impossible endoscopic retrograde drainage: A multicenter, randomized phase II Study. ⁶²	Marx M...Giovannini M	36204790	2022
37	An unusual cause of obstructive jaundice in childhood: Intra-choledochal malignant neuroendocrine tumour. ⁶²	Gopan A...Yachha SK	35716114	2022
38	Percutaneous transluminal forceps biopsy with an adjustable curved sheath for obstructive jaundice. ⁶²	Tian Y...Niu H	35616175	2022
39	Eosinophilic gastroenteritis: A case series of a rare disease from an apex Tertiary Care Center in South India. ⁶²	Janardhanan S...Ardhanari R	36412352	2022
40	Successful endoscopic treatment of huge infected biloma and hepatic abscess after endoscopic ultrasound-guided hepaticogastrostomy with brain abscess. ⁶²	Takahashi K...Kato N	35763152	2022
41	Spontaneous retroperitoneal haemorrhage from pancreatoduodenal artery (PDA) rupture and associated complications. ⁶²	Tan EWK...Low JK	36253011	2022
42	Biliary cystadenoma: Case report with MRI findings and surgical confirmation. ⁶²	Hoti KD...Choudhary J	35991384	2022
43	Outcome of primary ERCP versus primary PTC for biliary drainage in malignant hilar biliary strictures: a systematic review and meta-analysis. ⁶²	Van Eecke E...Hindryckx P	35941311	2022
44	Gastrojejunostomy versus endoscopic duodenal stent placement for gastric outlet obstruction in patients with unresectable pancreatic cancer: a propensity score-matched analysis. ⁶²	Tamura T...Kitano M	36258002	2022
45	Reply to letter to the editor "Re: Identification of Preoperative Risk Factors for Poor Survival in Patients with Resectable Pancreatic Cancer Treated with Upfront Surgery". ⁶²	Kondo N	36315986	2022
46	Acute Chest Syndrome Masquerading As Sepsis: A Rare Presentation of Sickle Cell Anemia Complication. ⁶²	Mohan B...Bairwa M	36381895	2022
47	The Laparoscopic Cholecystectomy and Common Bile Duct Exploration: A Single-Step Treatment of Pediatric Cholelithiasis and Choledocholithiasis. ⁶²	Pogorelic Z...Perko Z	36291520	2022
48	Malignant Neuroendocrine Tumor of Gall Bladder: An Incidental Finding. ⁶²	Chowdhury MM...Karim R	36189571	2022
49	High rates of recurrence of gallstone associated episodes following acute cholecystitis during long term follow-up: a retrospective comparative study of patients who did not receive surgery. ⁶²	Handler C...Kopelman D	36197463	2022
50	Pathogenic Novel Heterozygous Variant c.1076c>T p. (Ser359Phe) chr1: 120512166 in NOTCH2 Gene, Type 2 Alagille Syndrome Causing Neonatal Cholestasis: A Case Report. ⁶²	Uddin MS...Al Hatlani MM	36201396	2022

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Genes for Obstructive Jaundice

Genes related to Obstructive Jaundice (0 elite genes):

(show all 27)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	ALPP	Alkaline Phosphatase, Placental	Protein Coding	19.6	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	15625352 1995758 15813880
2	GGT1	Gamma-Glutamyltransferase 1	Protein Coding	15.69	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	18773671 19143075
3	SLC25A13	Solute Carrier Family 25 Member 13	Protein Coding	15.17	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	12692712 11343052
4	GPT	Glutamic--Pyruvic Transaminase	Protein Coding	12.2	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	1721943
5	SLC17A5	Solute Carrier Family 17 Member 5	Protein Coding	12.01	Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	15625352 2342668
6	MUC16	Mucin 16, Cell Surface Associated	Protein Coding	10.74	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
7	PSG2	Pregnancy Specific Beta-1-Glycoprotein 2	Protein Coding	9.43	Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	7634181 17262731
8	SERPINA3	Serpin Family A Member 3	Protein Coding	8.59	DISEASES inferred ¹⁴ ¹⁴
9	CCK	Cholecystokinin	Protein Coding	7.8	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	11344390 1995267 8391974
10	TTR	Transthyretin	Protein Coding	7.5	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	11702667
11	CEACAM5	CEA Cell Adhesion Molecule 5	Protein Coding	7.33	DISEASES inferred ¹⁴
12	ALB	Albumin	Protein Coding	7.09	DISEASES inferred ¹⁴
13	MIR122	MicroRNA 122	RNA Gene	6.94	DISEASES inferred ¹⁴ ¹⁴
14	BLVRB	Biliverdin Reductase B	Protein Coding	6.93	GeneCards inferred via : Publications (show sections)
15	GHR	Growth Hormone Receptor	Protein Coding	6.93	GeneCards inferred via : Publications (show sections)
16	AFP	Alpha Fetoprotein	Protein Coding	6.86	DISEASES inferred ¹⁴
17	LCAT	Lecithin-Cholesterol Acyltransferase	Protein Coding	6.86	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	8200119
18	F2	Coagulation Factor II, Thrombin	Protein Coding	6.71	DISEASES inferred ¹⁴
19	CRP	C-Reactive Protein	Protein Coding	6.28	DISEASES inferred ¹⁴
20	KRT7	Keratin 7	Protein Coding	6.2	DISEASES inferred ¹⁴
21	ABCB11	ATP Binding Cassette Subfamily B Member 11	Protein Coding	6.1	DISEASES inferred ¹⁴
22	NPC1	NPC Intracellular Cholesterol Transporter 1	Protein Coding	5.99	DISEASES inferred ¹⁴
23	VPS33B	VPS33B Late Endosome And Lysosome Associated	Protein Coding	5.92	DISEASES inferred ¹⁴
24	NPC2	NPC Intracellular Cholesterol Transporter 2	Protein Coding	5.89	DISEASES inferred ¹⁴
25	VIPAS39	VPS33B Interacting Protein, Apical-Basolateral Polarity Regulator, Spe-39 Homolog	Protein Coding	5.87	DISEASES inferred ¹⁴
26	SST	Somatostatin	Protein Coding	5.87	DISEASES inferred ¹⁴
27	SYP	Synaptophysin	Protein Coding	5.8	DISEASES inferred ¹⁴

Sources

Variations for Obstructive Jaundice

Sources

Expression for Obstructive Jaundice

Search GEO for disease gene expression data for Obstructive Jaundice.

Sources

Pathways for Obstructive Jaundice

Pathways related to Obstructive Jaundice according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	FOXA2 and FOXA3 transcription factor networks ⁶¹ Show member pathways FOXA transcription factor networks ⁶¹	10.56	TTR F2 ALB AFP

Sources

GO Terms for Obstructive Jaundice

Cellular components related to Obstructive Jaundice according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:0005576	10.2	TTR SERPINA3 PSG2 MUC16 LCAT GHR
2	extracellular exosome	GO:0070062	10.02	ALB BLVRB CEACAM5 F2 GGT1 GPT
3	extracellular space	GO:0005615	9.68	TTR SERPINA3 MUC16 MIR122 LCAT GPT