Obstructive Jaundice

Categories: Gastrointestinal diseases, Genetic diseases

Aliases & Classifications for Obstructive Jaundice

MalaCards integrated aliases for Obstructive Jaundice:

Name: Obstructive Jaundice 12 15 17
Jaundice, Obstructive 43 71
Obstructive Hyperbilirubinemia 12
Cholestatic Jaundice Syndrome 12
Cholestatic Jaundice 12
Jaundice Obstructive 54
Jaundice Cholestatic 54


External Ids:

Disease Ontology 12 DOID:13603
MeSH 43 D041781
NCIt 49 C34742
SNOMED-CT 67 44018007 59848001
UMLS 71 C0022354

Summaries for Obstructive Jaundice

MalaCards based summary : Obstructive Jaundice, also known as jaundice, obstructive, is related to bile acid synthesis defect, congenital, 1 and cholecystitis, and has symptoms including icterus and jaundice (not of newborn). An important gene associated with Obstructive Jaundice is GGT1 (Gamma-Glutamyltransferase 1), and among its related pathways/superpathways are IL-1 Family Signaling Pathways and Folate Metabolism. The drugs Lactulose and Ceftriaxone have been mentioned in the context of this disorder. Affiliated tissues include liver, pancreas and kidney, and related phenotypes are cardiovascular system and growth/size/body region

Related Diseases for Obstructive Jaundice

Diseases in the Obstructive Jaundice family:

Jaundice, Familial Obstructive, of Infancy

Diseases related to Obstructive Jaundice via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 966)
# Related Disease Score Top Affiliating Genes
1 bile acid synthesis defect, congenital, 1 32.0 TTR SLC25A13 GPT GGT1 ALB
2 cholecystitis 31.7 GPT F2 ALB
3 pancreatitis 31.4 TNF SLC17A5 IL6 GGT1 CRP
4 acute kidney failure 31.3 REN GPT F2 ALB
5 cholelithiasis 31.3 GPT GGT1 CRP ALB
6 biliary atresia 31.2 GPT GGT1 F2 ALB
7 bile duct cysts 31.1 SLC25A13 GPT GGT1
8 hepatic coma 31.0 GPT F2 ALB
9 hyperthyroidism 31.0 REN GPT CRP ALPP ALB
10 bile duct cancer 30.9 IL6 GPT ALB ABCC2
11 choledocholithiasis 30.9 SLC17A5 GPT GGT1 F2 CRP ALPP
12 extrahepatic cholestasis 30.9 GPT GGT1 ALPP ABCC2
13 ileus 30.8 TNF IL6 F2 CRP
14 duodenal ulcer 30.8 TNF IL6 GRP CXCL8
15 intestinal obstruction 30.8 IL6 GPT CRP ALB
16 acute kidney tubular necrosis 30.8 REN IL6 GGT1 ALB
17 acute pancreatitis 30.8 TNF IL6 GPT CXCL8 CRP ALB
18 lymphadenitis 30.7 TNF CXCL8 CRP
19 fatty liver disease, nonalcoholic 1 30.7 SLC17A5 GPT GGT1
20 acute cholangitis 30.7 IL6 GPT GGT1 F2 CRP ALB
21 kidney disease 30.7 TTR TNF REN IL6 EDN1 CRP
22 bilirubin metabolic disorder 30.7 SLC17A5 GPT GGT1 F2 CRP ALB
23 fascioliasis 30.6 SLC17A5 GPT GGT1 ALPP ALB
24 disseminated intravascular coagulation 30.6 TNF IL6 GPT F2 CRP
25 portal hypertension 30.6 TNF GPT F2 EDN1 CXCL8 ALB
26 gastric ulcer 30.6 TNF IL6 CXCL8
27 volvulus of midgut 30.6 GPT F2 CRP ALB
28 amyloidosis 30.6 TTR TNF IL6 CRP ALB
29 esophageal varix 30.6 GPT GGT1 F2 ALB
30 abdominal tuberculosis 30.6 TNF F2 CRP ALB
31 miliary tuberculosis 30.5 TNF CRP ALB
32 liver cirrhosis 30.5 TTR SLC17A5 REN GPT GGT1 F2
33 parenteral nutrition-associated cholestasis 30.5 SLC17A5 GPT GGT1 ALPP
34 ascending cholangitis 30.5 GPT F2 CRP ALB
35 hepatitis 30.5 TNF SLC17A5 GPT GGT1 F2
36 myeloma, multiple 30.5 TTR TNF IL6 CXCL8 CRP ALB
37 viral hepatitis 30.5 TNF SLC17A5 IL6 GPT GGT1 F2
38 acute liver failure 30.5 SLC17A5 GPT F2 ALB
39 temporal arteritis 30.5 TNF IL6 CRP
40 hepatorenal syndrome 30.4 REN GPT F2 EDN1 ALB
41 pneumocystosis 30.4 TNF IL6 CRP ALB
42 autoimmune hepatitis 30.4 TNF SLC17A5 GPT GGT1 F2 ALB
43 granulomatous hepatitis 30.4 GPT CRP ALPP ALB
44 anuria 30.4 REN F2 CRP ALB
45 bacterial infectious disease 30.4 TNF IL6 CXCL8 CRP
46 peritonitis 30.4 TNF IL6 F2 CXCL8 CRP ALB
47 drug-induced hepatitis 30.4 TNF GPT ALB
48 varicose veins 30.4 TNF IL6 F2 CXCL8
49 pulmonary tuberculosis 30.4 TNF IL6 CRP ALB
50 thrombocytosis 30.4 IL6 F2 CRP ALB

Graphical network of the top 20 diseases related to Obstructive Jaundice:

Diseases related to Obstructive Jaundice

Symptoms & Phenotypes for Obstructive Jaundice

UMLS symptoms related to Obstructive Jaundice:

icterus, jaundice (not of newborn)

MGI Mouse Phenotypes related to Obstructive Jaundice:

# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10 ALB CLDN4 CRP EDN1 F2 GPBAR1
2 growth/size/body region MP:0005378 9.93 CEACAM1 CLDN4 EDN1 F2 GGT1 GPBAR1
3 homeostasis/metabolism MP:0005376 9.86 ABCC2 ALB CEACAM1 CLDN4 CRP EDN1
4 renal/urinary system MP:0005367 9.36 ABCC2 ALB CLDN4 EDN1 GGT1 GPBAR1

Drugs & Therapeutics for Obstructive Jaundice

Drugs for Obstructive Jaundice (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 95)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Lactulose Approved Phase 4 4618-18-2 11333
Ceftriaxone Approved Phase 4 73384-59-5 5479530 5361919
Levofloxacin Approved, Investigational Phase 4 100986-85-4 149096
Ofloxacin Approved Phase 4 82419-36-1 4583
5 Antibiotics, Antitubercular Phase 4
6 Anti-Bacterial Agents Phase 4
7 Anti-Infective Agents Phase 4
8 Antitubercular Agents Phase 4
9 Renal Agents Phase 4
10 Cytochrome P-450 Enzyme Inhibitors Phase 4
11 Topoisomerase Inhibitors Phase 4
12 Anti-Infective Agents, Urinary Phase 4
13 Cytochrome P-450 CYP1A2 Inhibitors Phase 4
Trioxsalen Approved Phase 2, Phase 3 3902-71-4 5585
Nicotinamide Approved, Investigational Phase 3 98-92-0 936
Folic acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
Methionine Approved, Nutraceutical Phase 3 63-68-3 6137
Niacin Approved, Investigational, Nutraceutical Phase 3 59-67-6 938
19 Hematoporphyrin Derivative Phase 2, Phase 3
20 Dihematoporphyrin Ether Phase 2, Phase 3
21 Vitamins Phase 3
22 Micronutrients Phase 3
23 Trace Elements Phase 3
24 Vitamin B3 Phase 3
25 Hypolipidemic Agents Phase 3
26 Vitamin B9 Phase 3
27 Nutrients Phase 3
28 Vitamin B Complex Phase 3
29 Vasodilator Agents Phase 3
30 Folate Phase 3
31 Lipid Regulating Agents Phase 3
32 Antimetabolites Phase 3
33 Nicotinic Acids Phase 3
Neostigmine Approved, Vet_approved Phase 1, Phase 2 59-99-4 4456
Ursodeoxycholic acid Approved, Investigational Phase 2 128-13-2 31401
Ethanol Approved Phase 2 64-17-5 702
Copper Approved, Investigational Phase 2 7440-50-8 27099
Disulfiram Approved Phase 2 97-77-8 3117
Temoporfin Approved, Investigational Phase 2 122341-38-2
40 Cholinergic Agents Phase 1, Phase 2
41 Autonomic Agents Phase 1, Phase 2
42 Cholinesterase Inhibitors Phase 1, Phase 2
43 Cholagogues and Choleretics Phase 2
44 Gastrointestinal Agents Phase 2
45 Dermatologic Agents Phase 2
46 Photosensitizing Agents Phase 2
47 Omega 3 Fatty Acid Phase 1, Phase 2
48 Olive Phase 1, Phase 2
Bilirubin Phase 1, Phase 2 635-65-4, 69853-43-6 5280352 21252250
50 Fat Emulsions, Intravenous Phase 1, Phase 2

Interventional clinical trials:

(show top 50) (show all 82)
# Name Status NCT ID Phase Drugs
1 Distal Malignant Biliary Obstruction: A Prospective Randomised Trial Comparing Metal and Plastic Stents in Palliation of Symptomatic Jaundice Unknown status NCT00731419 Phase 4
2 Prospective Evaluation of Stent Patency in Patients With Benign Biliary Obstruction of the Wing Biliary Stent (Viaduct™) Unknown status NCT01818050 Phase 4
3 Phase 4 Study :Human Kidney Histopathology in Acute Obstructive Jaundice: a Prospective Study Completed NCT01090193 Phase 4
4 Re-intervention for Occluded Biliary Metal Stent in Malignant Distal Bile Duct Obstruction: a Prospective Randomized Multi-center Trial Comparing Covered and Uncovered Metal Stent Completed NCT01315522 Phase 4
5 Randomized Trial of Short Antibiotic Course to Decrease Post ERCP Cholangitis Recruiting NCT03087656 Phase 4 Ceftriaxone;Levofloxacin
6 Preoperative Biliary Drainage for the Lower Malignant Obstructive Jaundice: A Phase III, Randomized, Controlled, Single Center Study. Unknown status NCT01744938 Phase 3
7 Open-label Observational Study of Plastic Cylindrical Fiber Optic Diffuser (Pioneer Optics) in Photodynamic Therapy for the Management of Cholangiocarcinoma. Unknown status NCT01755013 Phase 2, Phase 3
8 Effect of Palliative Biliary Stenting Versus Conservative Treatment on the Quality of Life (QOL) of Patients With Unresectable Carcinoma of the Gallbladder With Hiliar Block: A Randomised Controlled Trial Completed NCT00391183 Phase 2, Phase 3
9 A Multicenter, Double-Blind, Placebo-Controlled, Randomized Trial of Efficacy and Safety of Remaxol®, a Solution for Intravenous Infusions Produced by STPF "POLYSAN" (Russia), in Patients With Mechanical Jaundice of Non-Malignant Origin Recruiting NCT03418935 Phase 3 Remaxol (succinate + methionine + inosine + nicotinamide);Ringer's Solution
10 A Multicenter, Double-blind, Placebo-controlled, Randomized Trial of the Efficacy and Safety of Remaxol®, a Solution for Infusions Produced by STPF POLYSAN (Russia), in Patients With Malignant Mechanical Jaundice Recruiting NCT03416062 Phase 3 Remaxol®;Ringer's Solution
11 Comparison Between Two Methods of Bilateral Stenting for Malignant Hilar Obstruction Withdrawn NCT01622803 Phase 3
12 The Prevention and Treatment of SIRS in Patients With Cholestatic Jaundice After Operation. Unknown status NCT02279147 Phase 1, Phase 2 neostigmine methylsulfate,raceanisodamine hydrochloride
13 The Effect of Ursodeoxycholic Acid in Liver Functional Restoration of Patients With Obstructive Jaundice After Endoscopic or Surgical Treatment Unknown status NCT01688375 Phase 2 Ursodeoxycholic Acid
14 A Double Blind, Randomized Controlled Prospective Trial of Endo-biliary Radio-frequency Ablation for Maintenance of Metal Stent Patency in Patients With Malignant Obstructive Jaundice Unknown status NCT01275768 Phase 1, Phase 2
15 Evaluation of Preoperative Biliary Drainage on Outcome of Pancreatoduodenectomy: A Multicenter Randomized Controlled Study Unknown status NCT01941342 Phase 2
16 Self Expanding Metal Stents (SEMS) or Plastic Stents to Relieve Obstruction of Obstructive Jaundice Prior to Resection of Periampullary Tumors. Completed NCT02166840 Phase 2
17 Investigation of the Effect of Intraductal Radiofrequency Ablation in Inoperable Biliopancreatic Tumors Complicated With Obstructive Jaundice Completed NCT02468076 Phase 2
18 Phase 2 Study of Randomized Controlled Trial of Pancreatic Enzyme Supplementation in Patients With Unresectable Pancreatic Cancer Completed NCT01587534 Phase 2 Norzyme
19 Phase II Open Labeled Trial of Disulfiram With Copper in Metastatic Breast Cancer Recruiting NCT03323346 Phase 2 Disulfiram
20 Safety and Tumoricidal Effect of Low Dose Temoporfin Photodynamic Therapy in Patients With Inoperable Bile Duct Cancers (Foscan® Study) Recruiting NCT03003065 Phase 2 Temoporfin
21 Prospective Evaluation of the Use of a Biodegradable Endoprothesis in the Prevention of Post-Endoscopic Retrograde CholoangioPancreatography Pancreatitis Not yet recruiting NCT03977779 Phase 2
22 Compassionate Use of an Intravenous Fat Emulsion Comprised of Soy Oil, Medium Chain Triglycerides, Olive Oil, and Fish Oil for Neonates With Parenteral Nutrition Induced Liver Injury Terminated NCT02721277 Phase 1, Phase 2 SMOFlipid
23 Treatment of Unresectable Hepatocellular Cancer With Opioid Growth Factor: a Phase I Study Completed NCT00706576 Phase 1 Infusion of opioid growth factor
24 Effect of Methylene Blue on Perioperative Organ Function in Patients With Obstructive Jaundice Enrolling by invitation NCT04109859 Phase 1 Saline;Methylene Blue
25 The Role of Cholangioscopy and Biliary Radio Frequency Ablation in the Management of Occluded Biliary Self-expanding Metal Stent. Unknown status NCT03133026
26 Quorum Sensing Signal Molecules (QSSMs) and Immune Dysfunction in Patients Undergoing Endoscopic Retrograde Cholangiopancreatography (ERCP) for Obstructive Jaundice Unknown status NCT01367821
27 Endoscopic Retrograde Cholangiopancreatography, Endoscopic Ultrasound and Interventional Endoscopy in Pancreatico-biliary, Gastrointestinal and Esophageal Disorders Unknown status NCT01438385
28 Impaired T-Lymphocyte Proliferative Function in Biliary Atresia Children With Prolonged Jaundice Unknown status NCT00155194
29 Clinical Study of Abdominal Drainage in Laparoscopic Common Bile Duct Exploration With Primary Closure Unknown status NCT03120754
30 Comparison Between Fully Covered and Partially Covered Self-expandable Metal Stents With Anti-migration System for Malignant Distal Biliary Obstruction Unknown status NCT02255669
31 The Necessity of Bile Cultures in Patients With Acute Cholangitis Unknown status NCT02601417
32 Percutaneous Transhepatic Cholangiography Versus Endoscopic Ultrasound Guided Biliary Drainage in Advanced Biliary Tract Malignancy That Failed ERCP (PETRUS Study): A Randomized Pilot Study Unknown status NCT01686425
33 Feeding Tolerance in Preterm Infants: Randomized Trial of Bolus Feeding Every 4 Hours Versus Every 3 Hours Unknown status NCT00450697
34 Endoscopic Ultrasound-Guided Biliary Drainage (EUS-BD) Compared to Standard Transpapillary Biliary Drainage (ERCP-TP) for Palliation of Jaundice in Unresectable Cancer of the Head of the Pancreas (BILPAL TRIAL) Unknown status NCT03063554
35 Comparison Between Endoscopic Stenting and Cholecystojejunostomy for PreoperativeDrainage Before Pancreaticoduodenectomy Unknown status NCT01913275
36 Continuous Transversus Abdominis Plane Blocks for Patients Undergoing Major Abdominal Surgery: A Prospective, Controlled, Randomized, Double-blind Trial Unknown status NCT01871168
37 Multicenter Prospective Randomized Controlled Trial of the Nitinol ZILVER Expandable Endoprosthesis in the Palliation of Extrahepatic Malignant Biliary Obstruction Completed NCT00196105
38 Prospective Study on the Comparison Between the Clinicopathological Outcomes According to the Methods of Preoperative Biliary Drainage in Periampullary Cancers Causing Obstructive Jaundice Completed NCT01134276
39 A Double-blind, Randomized, Controlled Trial of Air Insufflation Versus Carbon Dioxide Insufflation During Endoscopic Retrograde Cholangiopancreatography (ERCP). Completed NCT01321203
40 Safety and Efficacy of n-3 Fatty Acid-based Parenteral Nutrition in Patients With Obstructive Jaundice: A Propensity-matched Study Completed NCT03376945 trail cohort;control cohort
41 Observational Study for Safety and Efficacy of Photodynamic Therapy for Bile Duct Invasion of Hepatocellular Carcinoma Completed NCT01506115 Photofrin
42 Biliary Cannulation During Endoscopic Retrograde Cholangiopancreatography: Precut Versus Conventional Cannulation. A Prospective Randomized Study Completed NCT02477228
43 Endoscopic Ultrasound-guided Biliary Drainage for Malignant Biliary Obstruction After Failed ERCP: a Single Italian Center Experience Completed NCT03510754
44 Endoscopic Versus Percutaneous Biliary Drainage For Hilar Block Due to Carcinoma Gall Bladder: A Randomized Prospective Trial and Quality Of Life Assessment Completed NCT00409864
45 Biliary Atresia, Hepatic Buffer Response and Sevoflurane Completed NCT02471209 Sevoflurane
46 Study of Stent Insertion Combined With or Without Brachytherapy in Patients With Inoperable Malignant Biliary Obstruction Completed NCT02001779
47 Early Versus Late Cholecystectomy After Clearance of Common Bile Duct Stones by Endoscopic Retrograde Cholangiopancreatography Completed NCT02460315
48 Predicting Acute-on-Chronic Liver Failure in Cirrhosis (PREDICT) Study Completed NCT03056612
49 The Pre-operative Pathway in Pancreatic Head Malignancy-assessment of the Diagnostic Accuracy of Staging CT Scan Completed NCT02296736
50 Randomized Trial Comparing Endoscopic Ultrasound-guided Biliary Drainage (EUS-BD) and Endoscopic Retrograde Cholangiopancreatography (ERCP) for Malignant Distal Biliary Obstruction Completed NCT03054987

Search NIH Clinical Center for Obstructive Jaundice

Cochrane evidence based reviews: jaundice, obstructive

Genetic Tests for Obstructive Jaundice

Anatomical Context for Obstructive Jaundice

MalaCards organs/tissues related to Obstructive Jaundice:

Liver, Pancreas, Kidney, Testes, Lung, Heart, Lymph Node

Publications for Obstructive Jaundice

Articles related to Obstructive Jaundice:

(show top 50) (show all 7250)
# Title Authors PMID Year
[Analysis of tear enzymes in the diagnosis of obstructive jaundice associated with subhepatic cholestasis]. 54 61
19143075 2008
CEA, CA 19-9, and CA 125 in the differential diagnosis of benign and malignant pancreatic diseases with or without jaundice. 54 61
17262731 2007
Contrasting liver function test patterns in obstructive jaundice due to biliary strictures [corrected] and stones. 54 61
15625352 2005
[Clinical study on the changes of growth hormone/insulin-like growth factor-I axis in patient with obstructive jaundice]. 54 61
11702667 2001
Factors predicting nutritional derangements in patients with obstructive jaundice: multivariate analysis. 54 61
11344390 2001
Activity of class I and II isoenzymes of alcohol dehydrogenase measured by a fluorometric method in the sera of patients with obstructive jaundice. 54 61
9247733 1997
Clinical values of CA19-9, CA125 and CEA in malignant obstructive jaundice. 54 61
7634181 1995
Discrepancies between lipoprotein(a) concentrations in icteric sera measured by immunonephelometry and electroimmunodiffusion. 54 61
8200119 1994
T-lymphocyte transformation in experimental obstructive jaundice: the role of serum-suppressive factors. 54 61
8109118 1993
Role of endogenous bile on basal and postprandial CCK release in humans. 54 61
8391974 1993
Human lymphocyte responsiveness is not enhanced by relief of biliary obstruction: an in-vitro study. 54 61
2025801 1991
Bile acids in human plasma interfere with cholecystokinin bioassay using dispersed pancreatic acini. 54 61
1995267 1991
[Reduction of erythrocyte membrane band 4.2 protein in patients with obstructive jaundice]. 54 61
2255052 1990
A combination of raised serum AST:ALT ratio and erythrocyte mean cell volume level detects excessive alcohol consumption. 54 61
2342668 1990
Biliary tract bleeding with obstructive jaundice after endoscopic ultrasound-guided fine-needle aspiration of a pancreatic head tumor. 61
31165459 2020
Single-session multiple stent deployment using moving cell stent without dilating initial stent mesh to treat malignant hilar biliary obstruction (with videos). 61
31628892 2020
A rare cause of obstructive jaundice: Is surgery the only option? 61
31945361 2020
Involvement of the p38 MAPK-pHsp27 pathway in vascular hyporeactivity induced by obstructive jaundice in rats. 61
31810142 2020
Effect of N-acetylcysteine on liver and kidney function tests after surgical bypass in obstructive jaundice: A randomized controlled trial. 61
31280997 2020
Stent placement with iodine-125 seeds strand effectively extends the duration of stent patency and survival in patients with unresectable malignant obstructive jaundice. 61
31906735 2020
Life-threatening duodenal perforation complicating endoscopic retrograde cholangiopanceatography: A case series. 61
31978721 2020
The role of seed implantation in patients with unresectable pancreatic carcinoma after relief of obstructive jaundice using ERCP. 61
31564517 2020
A case of perihilar cholangiocarcinoma with bilateral ligamentum teres hepatis treated with hepatopancreatoduodenectomy. 61
32002706 2020
[Synchronous double primary cancers of a mixed adenoneuroendocrine carcinoma of the distal bile duct and a carcinoma in situ in the perihilar bile duct]. 61
32037364 2020
Primary Pancreatic lymphoma: a rare clinical entity. 61
31907215 2020
Endoscopic ultrasound-guided biliary drainage for malignant biliary obstruction after failed ERCP in low performance status patients. 61
31409577 2020
No Advantage of Expanded Polytetrafluoroethylene and Fluorinated Ethylene Propylene-Covered Stents over Uncovered Nitinol Stents for Percutaneous Palliation of Malignant Infrahilar Biliary Obstruction: Results of a Single-Center Prospective Randomized Trial. 61
31627908 2020
No evidence of improved efficacy of covered stents over uncovered stents in percutaneous palliation of malignant hilar biliary obstruction: results of a prospective randomized trial. 61
31385047 2020
The outcomes of biliary drainage by percutaneous transhepatic cholangiography for the palliation of malignant biliary obstruction in England between 2001 and 2014: a retrospective cohort study. 61
31980509 2020
Dexmedetomidine activates the PI3K/Akt pathway to inhibit hepatocyte apoptosis in rats with obstructive jaundice. 61
31772637 2019
Treatment of obstructive jaundice caused by hepatic artery pseudoaneurysm after liver transplantation: A case report. 61
31860951 2019
Silent time bomb: a case report of pancreatic head arteriovenous malformation presenting with obstructive jaundice. 61
31846563 2019
Clonorchis sinensis and clonorchiasis. 61
31862466 2019
A Case of IgG4-related Sclerosing Cholangitis Mimicking Cholangiocarcinoma Diagnosed by Endoscopic Ultrasound-guided Fine-needle Aspiration. 61
31875638 2019
Klatskin-mimicking neuroendocrine tumor. 61
31696723 2019
Spontaneous Lymphocele Presenting with Obstructive Jaundice. 61
31866315 2019
Retrograde Pancreatic Duct Stent Migration into the Biliary Tract Presenting as a Rare Early Complication of Pancreaticoduodenectomy (Whipple Procedure). 61
31831724 2019
Clinical Presentation, Diagnosis, and Management of Air Embolism During Endoscopic Retrograde Cholangiopancreatography. 61
31803307 2019
Yinchenhao decoction attenuates obstructive jaundice-induced liver injury and hepatocyte apoptosis by suppressing protein kinase RNA-like endoplasmic reticulum kinase-induced pathway. 61
31749592 2019
Metachronous Pancreatic Metastasis from Rectal Cancer that Masqueraded as a Primary Pancreatic Cancer: A Rare and Difficult-to-Diagnose Metastatic Tumor in the Pancreas. 61
31784503 2019
[Autoimmune pancreatitis]. 61
31791461 2019
Giant choledochal cyst. An unusual cause of obstructive jaundice in an adult. 61
31104867 2019
Respiratory failure and macrophage activation syndrome as an onset of systemic lupus erythematosus: A case report. 61
31799315 2019
A rare case of symptomatic grossly-visible biliary intraepithelial neoplasia mimicking cholangiocarcinoma. 61
31711502 2019
Validity and safety of endoscopic biliary stenting for biliary stricture associated with IgG4-related pancreatobiliary disease during steroid therapy. 61
31673612 2019
Obstructive jaundice - an exceedingly rare association. 61
31738922 2019
Screening acute cholangitis patients for sepsis. 61
31566288 2019
Serum MMP-7 in the Diagnosis of Biliary Atresia. 61
31604829 2019
EUS-guided hepaticogastrostomy. 61
31897377 2019
Therapeutic EUS: New tools, new devices, new applications. 61
31417067 2019

Variations for Obstructive Jaundice

Expression for Obstructive Jaundice

Search GEO for disease gene expression data for Obstructive Jaundice.

Pathways for Obstructive Jaundice

Pathways related to Obstructive Jaundice according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
Show member pathways
12.02 TNF IL6 EDN1 CXCL8
Show member pathways
3 11.74 TNF TJP1 IL6 F2 CXCL8 CLDN4
4 11.62 TJP1 IL6 CXCL8
5 11.62 TNF IL6 EDN1 CXCL8
6 11.58 TNF IL6 CXCL8
Show member pathways
11.49 TNF IL6 CXCL8
8 11.43 TNF IL6 CXCL8
9 11.36 TNF IL6 EDN1 CXCL8
10 11.33 TNF IL6 CXCL8
11 11.3 TNF IL6 CXCL8
12 11.22 TTR F2 ALB
13 11.04 TNF IL6 ABCC2
14 10.2 TNF IL6 CXCL8 CRP

GO Terms for Obstructive Jaundice

Cellular components related to Obstructive Jaundice according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 TTR TNF REN IL6 GRP F2
2 extracellular space GO:0005615 9.4 TTR TNF REN IL6 GRP GPT
3 intercellular canaliculus GO:0046581 9.16 TJP1 ABCC2

Biological processes related to Obstructive Jaundice according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.76 TTR IL6 F2 ALB
2 cellular response to lipopolysaccharide GO:0071222 9.67 TNF IL6 CXCL8 ABCC2
3 positive regulation of smooth muscle cell proliferation GO:0048661 9.58 TNF IL6 EDN1
4 thyroid hormone transport GO:0070327 9.43 TTR ABCC2
5 acute-phase response GO:0006953 9.43 IL6 F2 CRP
6 response to lipopolysaccharide GO:0032496 9.35 TJP1 REN GGT1 EDN1 ABCC2
7 positive regulation of JAK-STAT cascade GO:0046427 9.33 TNF IL6 F2
8 positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway GO:1900738 9.32 GRP F2
9 negative regulation of lipid storage GO:0010888 8.8 TNF IL6 CRP

Molecular functions related to Obstructive Jaundice according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.26 TNF IL6 EDN1 CXCL8
2 identical protein binding GO:0042802 9.17 TTR TNF SLC25A13 CRP CLDN4 CEACAM1

Sources for Obstructive Jaundice

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
54 Novoseek
57 OMIM via Orphanet
61 PubMed
70 Tocris
72 UMLS via Orphanet
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