MCID: OBS001
MIFTS: 49

Obstructive Jaundice

Categories: Gastrointestinal diseases, Genetic diseases

Aliases & Classifications for Obstructive Jaundice

MalaCards integrated aliases for Obstructive Jaundice:

Name: Obstructive Jaundice 12 15 17
Jaundice, Obstructive 44 72
Obstructive Hyperbilirubinemia 12
Cholestatic Jaundice Syndrome 12
Cholestatic Jaundice 12
Jaundice Obstructive 55
Jaundice Cholestatic 55

Classifications:



External Ids:

Disease Ontology 12 DOID:13603
MeSH 44 D041781
NCIt 50 C34742
SNOMED-CT 68 44018007 59848001
UMLS 72 C0022354

Summaries for Obstructive Jaundice

MalaCards based summary : Obstructive Jaundice, also known as jaundice, obstructive, is related to cholecystitis and acute kidney failure, and has symptoms including icterus and jaundice (not of newborn). An important gene associated with Obstructive Jaundice is ALPP (Alkaline Phosphatase, Placental), and among its related pathways/superpathways are Immune response IFN alpha/beta signaling pathway and IL-1 Family Signaling Pathways. The drugs Lactulose and Ofloxacin have been mentioned in the context of this disorder. Affiliated tissues include liver, pancreas and testes, and related phenotypes are growth/size/body region and homeostasis/metabolism

Related Diseases for Obstructive Jaundice

Diseases in the Obstructive Jaundice family:

Jaundice, Familial Obstructive, of Infancy

Diseases related to Obstructive Jaundice via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 686)
# Related Disease Score Top Affiliating Genes
1 cholecystitis 31.4 GPT F2 ALB
2 acute kidney failure 31.2 REN HGF ALB
3 biliary atresia 31.1 HGF GPT ALB
4 hepatic coma 30.9 GPT F2 ALB
5 choledocholithiasis 30.8 SLC17A5 GPT F2 ALPP ALB
6 iga glomerulonephritis 30.8 REN IL6 ALB
7 abdominal tuberculosis 30.7 F2 ALB
8 pancreas disease 30.7 TNF IL6 ALB
9 bilirubin metabolic disorder 30.7 SLC17A5 GPT GGT1 F2 ALB
10 autoimmune hepatitis 30.6 GPT GGT1 F2
11 kidney disease 30.6 TTR REN IL6 EDN1 ALB
12 cholestasis 30.6 SLC25A13 GPT GGT1 F2 ALPP
13 fascioliasis 30.6 SLC17A5 GPT ALPP ALB
14 nutritional deficiency disease 30.6 TTR IL6 ALB
15 kawasaki disease 30.4 TNF IL6 ALB
16 sclerosing cholangitis 30.3 TNF GPBAR1 GGT1 ALB
17 portal hypertension 30.3 TNF GPT F2 EDN1 ALB
18 bacterial infectious disease 30.2 TNF IL6 CXCL8
19 acquired immunodeficiency syndrome 30.2 TNF IL6 ALB
20 viral hepatitis 30.2 TNF SLC17A5 GPT GGT1 F2 ALB
21 hepatorenal syndrome 30.2 REN F2 EDN1 ALB
22 acute pyelonephritis 30.1 IL6 CXCL8 ALB
23 hepatitis 30.1 TNF SLC17A5 GPT GGT1 F2
24 hepatitis e 30.0 TNF GPT F2 ALB
25 hepatitis a 30.0 TNF GPT F2 ALB
26 toxic shock syndrome 30.0 TNF IL6 CXCL8
27 cholangitis 30.0 TNF IL6 GPT GPBAR1 GGT1 F2
28 peripheral nervous system disease 30.0 TTR TNF IL6 ALB
29 cholangitis, primary sclerosing 30.0 GPT GPBAR1 GGT1 ALB
30 autosomal dominant polycystic kidney disease 29.9 REN EDN1 ALB
31 acute cystitis 29.9 IL6 CXCL8 ALB
32 gastroenteritis 29.8 TNF IL6 CXCL8 ALB
33 compartment syndrome 29.8 TNF SLC17A5 F2 ALB
34 opisthorchiasis 29.8 TNF GPT CXCL8
35 gastrointestinal system cancer 29.8 TNF IL6 F2 ALB
36 peritonitis 29.8 TNF IL6 F2 CXCL8 ALB
37 myeloma, multiple 29.8 TNF IL6 HGF CXCL8 ALB
38 monocytic leukemia 29.7 TNF IL6 CXCL8
39 intestinal disease 29.7 TNF IL6 CXCL8 ALB
40 diabetes mellitus 29.7 TNF REN IL6 EDN1 ALB
41 protein-energy malnutrition 29.7 TTR TNF IL6 GPT ALB
42 respiratory failure 29.6 TTR TNF CXCL8 ALB
43 biliary tract disease 29.5 SLC25A13 GPBAR1 GGT1 F2 ALB
44 short bowel syndrome 29.5 TTR NTS HGF
45 pyelonephritis 29.5 TNF IL6 CXCL8 ALB
46 appendicitis 29.5 TNF IL6 CXCL8 ALB
47 alcoholic liver cirrhosis 29.4 SLC17A5 F2 CXCL8 ALB
48 fatty liver disease 29.4 TNF SLC17A5 IL6 GGT1 CXCL8
49 hepatic tuberculosis 29.4 GPT GGT1 F2 ALPP ALB
50 lung disease 29.3 TNF IL6 EDN1 CXCL8

Graphical network of the top 20 diseases related to Obstructive Jaundice:



Diseases related to Obstructive Jaundice

Symptoms & Phenotypes for Obstructive Jaundice

UMLS symptoms related to Obstructive Jaundice:


icterus, jaundice (not of newborn)

MGI Mouse Phenotypes related to Obstructive Jaundice:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.9 EDN1 F2 GGT1 GPBAR1 HGF IL6
2 homeostasis/metabolism MP:0005376 9.73 ALB EDN1 F2 GGT1 GPBAR1 IL6
3 renal/urinary system MP:0005367 9.23 ALB EDN1 GGT1 GPBAR1 IL6 REN

Drugs & Therapeutics for Obstructive Jaundice

Drugs for Obstructive Jaundice (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 98)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lactulose Approved Phase 4 4618-18-2 11333
2
Ofloxacin Approved Phase 4 82419-36-1 4583
3
Ceftriaxone Approved Phase 4 73384-59-5 5479530 5361919
4
Levofloxacin Approved, Investigational Phase 4 100986-85-4 149096
5 Anti-Bacterial Agents Phase 4
6 Anti-Infective Agents Phase 4
7 Antibiotics, Antitubercular Phase 4
8 Cytochrome P-450 Enzyme Inhibitors Phase 4
9 Renal Agents Phase 4
10 Antitubercular Agents Phase 4
11 Topoisomerase Inhibitors Phase 4
12 Anti-Infective Agents, Urinary Phase 4
13 Cytochrome P-450 CYP1A2 Inhibitors Phase 4
14
Trioxsalen Approved Phase 2, Phase 3 3902-71-4 5585
15
Nicotinamide Approved, Investigational Phase 3 98-92-0 936
16
Folic acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
17
Methionine Approved, Nutraceutical Phase 3 63-68-3 6137
18
Niacin Approved, Investigational, Nutraceutical Phase 3 59-67-6 938
19 Dihematoporphyrin Ether Phase 2, Phase 3
20 Hematoporphyrin Derivative Phase 2, Phase 3
21 Micronutrients Phase 3
22 Trace Elements Phase 3
23 Lipid Regulating Agents Phase 3
24 Vitamins Phase 3
25 Vitamin B9 Phase 3
26 Nicotinic Acids Phase 3
27 Vitamin B3 Phase 3
28 Folate Phase 3
29 Vitamin B Complex Phase 3
30 Nutrients Phase 3
31 Hypolipidemic Agents Phase 3
32 Vasodilator Agents Phase 3
33 Antimetabolites Phase 3
34
Neostigmine Approved, Vet_approved Phase 1, Phase 2 59-99-4 4456
35
Ursodeoxycholic acid Approved, Investigational Phase 2 128-13-2 31401
36
Ethanol Approved Phase 2 64-17-5 702
37
Disulfiram Approved Phase 2 97-77-8 3117
38
Copper Approved, Investigational Phase 2 7440-50-8 27099
39
Temoporfin Approved, Investigational Phase 2 122341-38-2
40 Cholinergic Agents Phase 1, Phase 2
41 Cholinesterase Inhibitors Phase 1, Phase 2
42 Autonomic Agents Phase 1, Phase 2
43 Gastrointestinal Agents Phase 2
44 Cholagogues and Choleretics Phase 2
45 Dermatologic Agents Phase 2
46 Photosensitizing Agents Phase 2
47 Pharmaceutical Solutions Phase 1, Phase 2
48 Omega 3 Fatty Acid Phase 1, Phase 2
49 Olive Phase 1, Phase 2
50 Fat Emulsions, Intravenous Phase 1, Phase 2

Interventional clinical trials:

(show top 50) (show all 80)
# Name Status NCT ID Phase Drugs
1 Distal Malignant Biliary Obstruction: A Prospective Randomised Trial Comparing Metal and Plastic Stents in Palliation of Symptomatic Jaundice Unknown status NCT00731419 Phase 4
2 Prospective Evaluation of Stent Patency in Patients With Benign Biliary Obstruction of the Wing Biliary Stent (Viaduct™) Unknown status NCT01818050 Phase 4
3 Phase 4 Study :Human Kidney Histopathology in Acute Obstructive Jaundice: a Prospective Study Completed NCT01090193 Phase 4
4 Re-intervention for Occluded Biliary Metal Stent in Malignant Distal Bile Duct Obstruction: a Prospective Randomized Multi-center Trial Comparing Covered and Uncovered Metal Stent Completed NCT01315522 Phase 4
5 Randomized Trial of Short Antibiotic Course to Decrease Post ERCP Cholangitis Recruiting NCT03087656 Phase 4 Ceftriaxone;Levofloxacin
6 Preoperative Biliary Drainage for the Lower Malignant Obstructive Jaundice: A Phase III, Randomized, Controlled, Single Center Study. Unknown status NCT01744938 Phase 3
7 Open-label Observational Study of Plastic Cylindrical Fiber Optic Diffuser (Pioneer Optics) in Photodynamic Therapy for the Management of Cholangiocarcinoma. Unknown status NCT01755013 Phase 2, Phase 3
8 Effect of Palliative Biliary Stenting Versus Conservative Treatment on the Quality of Life (QOL) of Patients With Unresectable Carcinoma of the Gallbladder With Hiliar Block: A Randomised Controlled Trial Completed NCT00391183 Phase 2, Phase 3
9 A Multicenter, Double-Blind, Placebo-Controlled, Randomized Trial of Efficacy and Safety of Remaxol®, a Solution for Intravenous Infusions Produced by STPF "POLYSAN" (Russia), in Patients With Mechanical Jaundice of Non-Malignant Origin Recruiting NCT03418935 Phase 3 Remaxol (succinate + methionine + inosine + nicotinamide);Ringer's Solution
10 A Multicenter, Double-blind, Placebo-controlled, Randomized Trial of the Efficacy and Safety of Remaxol®, a Solution for Infusions Produced by STPF POLYSAN (Russia), in Patients With Malignant Mechanical Jaundice Recruiting NCT03416062 Phase 3 Remaxol®;Ringer's Solution
11 Comparison Between Two Methods of Bilateral Stenting for Malignant Hilar Obstruction Withdrawn NCT01622803 Phase 3
12 The Prevention and Treatment of SIRS in Patients With Cholestatic Jaundice After Operation. Unknown status NCT02279147 Phase 1, Phase 2 neostigmine methylsulfate,raceanisodamine hydrochloride
13 The Effect of Ursodeoxycholic Acid in Liver Functional Restoration of Patients With Obstructive Jaundice After Endoscopic or Surgical Treatment Unknown status NCT01688375 Phase 2 Ursodeoxycholic Acid
14 A Double Blind, Randomized Controlled Prospective Trial of Endo-biliary Radio-frequency Ablation for Maintenance of Metal Stent Patency in Patients With Malignant Obstructive Jaundice Unknown status NCT01275768 Phase 1, Phase 2
15 Evaluation of Preoperative Biliary Drainage on Outcome of Pancreatoduodenectomy: A Multicenter Randomized Controlled Study Unknown status NCT01941342 Phase 2
16 Self Expanding Metal Stents (SEMS) or Plastic Stents to Relieve Obstruction of Obstructive Jaundice Prior to Resection of Periampullary Tumors. Completed NCT02166840 Phase 2
17 Investigation of the Effect of Intraductal Radiofrequency Ablation in Inoperable Biliopancreatic Tumors Complicated With Obstructive Jaundice Completed NCT02468076 Phase 2
18 Phase 2 Study of Randomized Controlled Trial of Pancreatic Enzyme Supplementation in Patients With Unresectable Pancreatic Cancer Completed NCT01587534 Phase 2 Norzyme
19 Phase II Open Labeled Trial of Disulfiram With Copper in Metastatic Breast Cancer Recruiting NCT03323346 Phase 2 Disulfiram
20 Safety and Tumoricidal Effect of Low Dose Temoporfin Photodynamic Therapy in Patients With Inoperable Bile Duct Cancers (Foscan® Study) Recruiting NCT03003065 Phase 2 Temoporfin
21 Prospective Evaluation of the Use of a Biodegradable Endoprothesis in the Prevention of Post-Endoscopic Retrograde CholoangioPancreatography Pancreatitis Not yet recruiting NCT03977779 Phase 2
22 Compassionate Use of an Intravenous Fat Emulsion Comprised of Soy Oil, Medium Chain Triglycerides, Olive Oil, and Fish Oil for Neonates With Parenteral Nutrition Induced Liver Injury Terminated NCT02721277 Phase 1, Phase 2 SMOFlipid
23 Treatment of Unresectable Hepatocellular Cancer With Opioid Growth Factor: a Phase I Study Completed NCT00706576 Phase 1 Infusion of opioid growth factor
24 The Role of Cholangioscopy and Biliary Radio Frequency Ablation in the Management of Occluded Biliary Self-expanding Metal Stent. Unknown status NCT03133026
25 Quorum Sensing Signal Molecules (QSSMs) and Immune Dysfunction in Patients Undergoing Endoscopic Retrograde Cholangiopancreatography (ERCP) for Obstructive Jaundice Unknown status NCT01367821
26 Endoscopic Retrograde Cholangiopancreatography, Endoscopic Ultrasound and Interventional Endoscopy in Pancreatico-biliary, Gastrointestinal and Esophageal Disorders Unknown status NCT01438385
27 Clinical Study of Abdominal Drainage in Laparoscopic Common Bile Duct Exploration With Primary Closure Unknown status NCT03120754
28 Comparison Between Fully Covered and Partially Covered Self-expandable Metal Stents With Anti-migration System for Malignant Distal Biliary Obstruction Unknown status NCT02255669
29 The Pre-operative Pathway in Pancreatic Head Malignancy-assessment of the Diagnostic Accuracy of Staging CT Scan Unknown status NCT02296736
30 Percutaneous Transhepatic Cholangiography Versus Endoscopic Ultrasound Guided Biliary Drainage in Advanced Biliary Tract Malignancy That Failed ERCP (PETRUS Study): A Randomized Pilot Study Unknown status NCT01686425
31 Feeding Tolerance in Preterm Infants: Randomized Trial of Bolus Feeding Every 4 Hours Versus Every 3 Hours Unknown status NCT00450697
32 Endoscopic Ultrasound-Guided Biliary Drainage (EUS-BD) Compared to Standard Transpapillary Biliary Drainage (ERCP-TP) for Palliation of Jaundice in Unresectable Cancer of the Head of the Pancreas (BILPAL TRIAL) Unknown status NCT03063554
33 Comparison Between Endoscopic Stenting and Cholecystojejunostomy for PreoperativeDrainage Before Pancreaticoduodenectomy Unknown status NCT01913275
34 Continuous Transversus Abdominis Plane Blocks for Patients Undergoing Major Abdominal Surgery: A Prospective, Controlled, Randomized, Double-blind Trial Unknown status NCT01871168
35 Multicenter Prospective Randomized Controlled Trial of the Nitinol ZILVER Expandable Endoprosthesis in the Palliation of Extrahepatic Malignant Biliary Obstruction Completed NCT00196105
36 Prospective Study on the Comparison Between the Clinicopathological Outcomes According to the Methods of Preoperative Biliary Drainage in Periampullary Cancers Causing Obstructive Jaundice Completed NCT01134276
37 A Double-blind, Randomized, Controlled Trial of Air Insufflation Versus Carbon Dioxide Insufflation During Endoscopic Retrograde Cholangiopancreatography (ERCP). Completed NCT01321203
38 Safety and Efficacy of n-3 Fatty Acid-based Parenteral Nutrition in Patients With Obstructive Jaundice: A Propensity-matched Study Completed NCT03376945 trail cohort;control cohort
39 Observational Study for Safety and Efficacy of Photodynamic Therapy for Bile Duct Invasion of Hepatocellular Carcinoma Completed NCT01506115 Photofrin
40 Biliary Cannulation During Endoscopic Retrograde Cholangiopancreatography: Precut Versus Conventional Cannulation. A Prospective Randomized Study Completed NCT02477228
41 Endoscopic Ultrasound-guided Biliary Drainage for Malignant Biliary Obstruction After Failed ERCP: a Single Italian Center Experience Completed NCT03510754
42 Endoscopic Versus Percutaneous Biliary Drainage For Hilar Block Due to Carcinoma Gall Bladder: A Randomized Prospective Trial and Quality Of Life Assessment Completed NCT00409864
43 Biliary Atresia, Hepatic Buffer Response and Sevoflurane Completed NCT02471209 Sevoflurane
44 Study of Stent Insertion Combined With or Without Brachytherapy in Patients With Inoperable Malignant Biliary Obstruction Completed NCT02001779
45 Early Versus Late Cholecystectomy After Clearance of Common Bile Duct Stones by Endoscopic Retrograde Cholangiopancreatography Completed NCT02460315
46 Predicting Acute-on-Chronic Liver Failure in Cirrhosis (PREDICT) Study Completed NCT03056612
47 Randomized Trial Comparing Endoscopic Ultrasound-guided Biliary Drainage (EUS-BD) and Endoscopic Retrograde Cholangiopancreatography (ERCP) for Malignant Distal Biliary Obstruction Completed NCT03054987
48 Intra-luminal Radiofrequency Ablation for Inoperable Malignant Biliary Stenosis Completed NCT02841800
49 Colonization of Bile Ducts and Postoperative Infectious Complications of Pancreaticoduodenectomies Completed NCT03525067
50 Optimizing the Role of ERCP in Evaluating Indeterminate Bile Duct Strictures Completed NCT01580709

Search NIH Clinical Center for Obstructive Jaundice

Cochrane evidence based reviews: jaundice, obstructive

Genetic Tests for Obstructive Jaundice

Anatomical Context for Obstructive Jaundice

MalaCards organs/tissues related to Obstructive Jaundice:

41
Liver, Pancreas, Testes, Kidney, Lung, Colon, Lymph Node

Publications for Obstructive Jaundice

Articles related to Obstructive Jaundice:

(show top 50) (show all 7178)
# Title Authors PMID Year
1
[Analysis of tear enzymes in the diagnosis of obstructive jaundice associated with subhepatic cholestasis]. 9 38
19143075 2008
2
CEA, CA 19-9, and CA 125 in the differential diagnosis of benign and malignant pancreatic diseases with or without jaundice. 9 38
17262731 2007
3
Contrasting liver function test patterns in obstructive jaundice due to biliary strictures [corrected] and stones. 9 38
15625352 2005
4
[Clinical study on the changes of growth hormone/insulin-like growth factor-I axis in patient with obstructive jaundice]. 9 38
11702667 2001
5
Factors predicting nutritional derangements in patients with obstructive jaundice: multivariate analysis. 9 38
11344390 2001
6
Activity of class I and II isoenzymes of alcohol dehydrogenase measured by a fluorometric method in the sera of patients with obstructive jaundice. 9 38
9247733 1997
7
Clinical values of CA19-9, CA125 and CEA in malignant obstructive jaundice. 9 38
7634181 1995
8
Discrepancies between lipoprotein(a) concentrations in icteric sera measured by immunonephelometry and electroimmunodiffusion. 9 38
8200119 1994
9
T-lymphocyte transformation in experimental obstructive jaundice: the role of serum-suppressive factors. 9 38
8109118 1993
10
Role of endogenous bile on basal and postprandial CCK release in humans. 9 38
8391974 1993
11
Human lymphocyte responsiveness is not enhanced by relief of biliary obstruction: an in-vitro study. 9 38
2025801 1991
12
Bile acids in human plasma interfere with cholecystokinin bioassay using dispersed pancreatic acini. 9 38
1995267 1991
13
[Reduction of erythrocyte membrane band 4.2 protein in patients with obstructive jaundice]. 9 38
2255052 1990
14
A combination of raised serum AST:ALT ratio and erythrocyte mean cell volume level detects excessive alcohol consumption. 9 38
2342668 1990
15
Significance of biopsy with ERCP for diagnosis of bile duct invasion of DLBCL. 38
31093933 2019
16
Myeloid Sarcoma of the Parotid Gland and Stomach Presenting with Obstructive Jaundice: A Rare Presentation 38
30993960 2019
17
Acute kidney injury due to high-output external biliary drainage in a patient with malignant obstructive jaundice: a case report. 38
31405371 2019
18
A rare cause of obstructive jaundice: diagnosis by EUS and single-operator per-oral cholangioscopy. 38
31388616 2019
19
Functional changes of Paneth cells in the intestinal epithelium of mice with obstructive jaundice and after internal and external biliary drainage. 38
31429688 2019
20
Therapeutic EUS: New tools, new devices, new applications. 38
31417067 2019
21
Endoscopic ultrasound-guided biliary drainage for malignant biliary obstruction after failed ERCP in low performance status patients. 38
31409577 2019
22
Primary non-ampullary duodenal follicular lymphoma presenting with obstructive jaundice. 38
31401784 2019
23
No evidence of improved efficacy of covered stents over uncovered stents in percutaneous palliation of malignant hilar biliary obstruction: results of a prospective randomized trial. 38
31385047 2019
24
Diagnostic Evaluation of Isotropic 3D MRCP Images in the Diagnosis of Cholangiocarcinoma. 38
31391432 2019
25
The role of percutaneous transhepatic biliary biopsy in the diagnosis of patients with obstructive jaundice: an initial experience. 38
31435082 2019
26
Obstructive Jaundice Caused by a Strangulated Petersen's Hernia. 38
31367894 2019
27
Effect of N-acetylcysteine on liver and kidney function tests after surgical bypass in obstructive jaundice: A randomized controlled trial. 38
31280997 2019
28
Health-Related Quality of Life evaluation in "left" versus "right" access for percutaneous transhepatic biliary drainage using EORTC QLQBIL-21 questionnaire: a randomized controlled trial. 38
31327040 2019
29
Ruptured Pyogenic Liver Abscess with Pneumoperitoneum 19 Years After Pancreatoduodenectomy. 38
31316049 2019
30
Endoscopic Ultrasound for Early Diagnosis of Pancreatic Cancer. 38
31344904 2019
31
[Perioperative antibiotic prophylaxis for pancreas resections with and without preoperative bile drainage : Is there room for improvement?] 38
30635700 2019
32
A case report of cholangiocarcinoma combined with moderately differentiated gastric adenocarcinoma. 38
31348232 2019
33
Retrospective analysis of seven cases of pancreatic mixed adenoneuroendocrine carcinoma from a high-volume center and review of the literature. 38
31296197 2019
34
A Challenging Diagnosis of Eosinophilic Cholangitis Requiring Resection of Extrahepatic Bile Ducts. 38
31423401 2019
35
Combined treatment of nonresectable cholangiocarcinoma complicated by obstructive jaundice. 38
30965145 2019
36
Tumour stage and resection margin status are independent survival factors following partial pancreatoduodenectomy for duodenal adenocarcinoma. 38
30972486 2019
37
Cholangioscopy and probe-based confocal laser endomicroscopy for real-time diagnosis of intraductal papillary mucinous neoplasm of the bile duct. 38
31243819 2019
38
Biliary tract bleeding with obstructive jaundice after endoscopic ultrasound-guided fine-needle aspiration of a pancreatic head tumor. 38
31165459 2019
39
Effects of Probiotic Use on Bacterial Translocation in Created Rat Models with Biliary Obstructions. 38
31258347 2019
40
Endoscopic biliary drainage in patients with cholangiocarcinoma - self-expanding metal versus polyethylene stents. 38
31122083 2019
41
Transhepatic forceps biopsy combined with biliary drainage in obstructive jaundice: safety and accuracy. 38
30511177 2019
42
Obstructive jaundice caused by an adenoma of the common hepatic duct. 38
29980303 2019
43
Endoscopic Palliation for Biliary and Pancreatic Malignancies: Recent Advances. 38
30665289 2019
44
Infrequent intrahepatic cystic neoplasm: dilemmas in diagnosis and management. 38
31151975 2019
45
Endoscopic deployment of multiple (≥ 3) metal stents for unresectable malignant hilar biliary strictures. 38
31061879 2019
46
Endoscopic papillary large balloon dilatation for the extraction of common bile duct stones. 38
30810329 2019
47
Endoscopic ultrasound-guided transmural gallbladder drainage in malignant obstruction using a novel lumen-apposing stent: a case series (with video). 38
31058208 2019
48
ACR Appropriateness Criteria® Radiologic Management of Biliary Obstruction. 38
31054746 2019
49
Concurrent lymphoma and hemophilia B in a pediatric patient: A case report. 38
31083180 2019
50
Giant choledochal cyst. An unusual cause of obstructive jaundice in an adult. 38
31104867 2019

Variations for Obstructive Jaundice

Expression for Obstructive Jaundice

Search GEO for disease gene expression data for Obstructive Jaundice.

Pathways for Obstructive Jaundice

Pathways related to Obstructive Jaundice according to GeneCards Suite gene sharing:

(show all 20)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.09 TNF IL6 HGF CXCL8
2
Show member pathways
12 TNF IL6 EDN1 CXCL8
3
Show member pathways
11.89 TNF IL6 GGT1 F2 ALB
4
Show member pathways
11.87 TNF IL6 F2
5 11.84 TNF IL6 CXCL8
6 11.83 IL6 HGF ALPP ALB
7 11.79 TNF IL6 EDN1
8 11.74 TNF IL6 CXCL8
9 11.73 TNF IL6 HGF CXCL8
10 11.69 TNF IL6 CXCL8
11 11.62 TNF IL6 EDN1 CXCL8
12 11.59 TNF IL6 CXCL8
13
Show member pathways
11.5 TNF IL6 CXCL8
14 11.43 TNF IL6 CXCL8
15 11.34 TNF IL6 CXCL8
16 11.25 TTR F2 ALB
17 11.03 TNF IL6 HGF CXCL8
18 10.95 TNF IL6 HGF CXCL8
19 10.82 TNF IL6 HGF EDN1 CXCL8
20 10.71 TNF IL6 CXCL8

GO Terms for Obstructive Jaundice

Cellular components related to Obstructive Jaundice according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.65 TTR TNF REN NTS IL6 HGF
2 extracellular space GO:0005615 9.36 TTR TNF REN IL6 HGF GPT

Biological processes related to Obstructive Jaundice according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.67 TNF IL6 HGF CXCL8
2 positive regulation of DNA-binding transcription factor activity GO:0051091 9.58 TNF IL6 EDN1
3 regulation of blood vessel size GO:0050880 9.48 NTS EDN1
4 embryonic digestive tract development GO:0048566 9.46 TNF CXCL8
5 cellular protein metabolic process GO:0044267 9.46 TTR IL6 F2 ALB
6 positive regulation of glial cell proliferation GO:0060252 9.43 TNF IL6
7 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.43 TNF HGF F2
8 negative regulation of lipid storage GO:0010888 9.32 TNF IL6
9 positive regulation of neuroinflammatory response GO:0150078 8.96 TNF IL6
10 positive regulation of smooth muscle cell proliferation GO:0048661 8.8 TNF IL6 EDN1

Molecular functions related to Obstructive Jaundice according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.92 TNF IL6 EDN1 CXCL8

Sources for Obstructive Jaundice

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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