Obstructive Jaundice

Categories: Gastrointestinal diseases, Genetic diseases

Aliases & Classifications for Obstructive Jaundice

MalaCards integrated aliases for Obstructive Jaundice:

Name: Obstructive Jaundice 12 15 17
Jaundice, Obstructive 43 71
Obstructive Hyperbilirubinemia 12
Cholestatic Jaundice Syndrome 12
Cholestatic Jaundice 12
Jaundice Obstructive 54
Jaundice Cholestatic 54


External Ids:

Disease Ontology 12 DOID:13603
MeSH 43 D041781
NCIt 49 C34742
SNOMED-CT 67 44018007
UMLS 71 C0022354

Summaries for Obstructive Jaundice

MalaCards based summary : Obstructive Jaundice, also known as jaundice, obstructive, is related to bile acid synthesis defect, congenital, 1 and acute kidney failure, and has symptoms including icterus and jaundice (not of newborn). An important gene associated with Obstructive Jaundice is GGT1 (Gamma-Glutamyltransferase 1), and among its related pathways/superpathways are Toll-Like receptor Signaling Pathways and Salmonella infection (KEGG). The drugs Lactulose and Ceftriaxone have been mentioned in the context of this disorder. Affiliated tissues include liver, pancreas and testes, and related phenotypes are cardiovascular system and homeostasis/metabolism

Related Diseases for Obstructive Jaundice

Diseases in the Obstructive Jaundice family:

Jaundice, Familial Obstructive, of Infancy

Diseases related to Obstructive Jaundice via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1023)
# Related Disease Score Top Affiliating Genes
1 bile acid synthesis defect, congenital, 1 32.2 TTR SLC25A13 GGT1 ALB
2 acute kidney failure 31.4 REN GPT F2 ALB
3 cholelithiasis 31.3 GPT GGT1 CRP ALB
4 cholecystitis 31.3 TLR4 GPT F2 ALB
5 pancreatitis 31.2 TNF SLC17A5 IL6 GGT1 CRP ALB
6 echinococcosis 31.2 TNF TLR4 IL6
7 biliary atresia 31.1 TNF GPT GGT1 F2 ALB
8 hepatic coma 31.0 GPT F2 ALB
9 choledocholithiasis 31.0 SLC17A5 GPT GGT1 F2 CRP ALPP
10 kidney disease 30.9 TTR REN IL6 EDN1 CRP ALB
11 duodenal ulcer 30.9 TNF TLR4 IL6 CXCL8
12 extrahepatic cholestasis 30.9 GPT GGT1 ALPP ABCC2
13 autoimmune pancreatitis 30.9 TNF TLR4 ALB
14 ileus 30.9 TNF IL6 F2 CRP
15 peptic ulcer disease 30.9 TNF CXCL8 ALB
16 hyperthyroidism 30.8 TNF IL6 GPT CRP ALPP ALB
17 pustulosis of palm and sole 30.8 TNF CXCL8 CRP
18 portal vein thrombosis 30.8 REN F2 CRP
19 volvulus of midgut 30.8 GPT CRP ALB
20 acute cholangitis 30.7 IL6 GPT GGT1 F2 CRP ALB
21 bilirubin metabolic disorder 30.7 SLC17A5 GPT GGT1 F2 CRP ALB
22 fatty liver disease, nonalcoholic 1 30.7 SLC17A5 GPT GGT1
23 fascioliasis 30.7 SLC17A5 GPT GGT1 ALPP ALB
24 gastric ulcer 30.7 TNF IL6 CXCL8
25 disseminated intravascular coagulation 30.7 TNF IL6 GPT F2 CRP
26 lymphadenitis 30.6 TNF TLR4 CXCL8 CRP
27 amyloidosis 30.6 TTR TNF IL6 CRP ALB
28 liver cirrhosis 30.6 TTR SLC17A5 REN GPT GGT1 F2
29 esophageal varix 30.6 GPT GGT1 F2 ALB
30 acute kidney tubular necrosis 30.6 TNF REN IL6 GGT1 ALB
31 anemia, x-linked, with or without neutropenia and/or platelet abnormalities 30.6 TTR CRP ALB
32 duodenitis 30.6 TNF CRP ALB
33 miliary tuberculosis 30.6 TNF CRP ALB
34 ascending cholangitis 30.5 GPT F2 CRP ALB
35 parenteral nutrition-associated cholestasis 30.5 SLC17A5 GPT GGT1 ALPP
36 hepatitis 30.5 TNF SLC17A5 GPT GGT1 F2
37 acute pancreatitis 30.5 TNF TLR4 IL6 GPT CXCL8 CRP
38 acute liver failure 30.5 SLC17A5 GPT F2 ALB
39 hepatorenal syndrome 30.5 REN GPT F2 EDN1 ALB
40 paracoccidioidomycosis 30.4 TNF TLR4 IL6 ALB
41 hydronephrosis 30.4 REN IL6 CXCL8 CRP ALB
42 pneumocystosis 30.4 TNF IL6 CRP ALB
43 varicose veins 30.4 TNF IL6 F2 CXCL8
44 temporal arteritis 30.4 TNF IL6 CRP
45 mental depression 30.4 TNF IL6 CRP
46 abdominal tuberculosis 30.4 TNF GPT F2 CRP ALB
47 autosomal dominant polycystic kidney disease 30.4 TNF REN EDN1 ALB
48 patent ductus arteriosus 1 30.4 REN EDN1 CRP ALB
49 portal hypertension 30.4 TNF TLR4 GPT F2 EDN1 CXCL8
50 thrombocytosis 30.4 IL6 F2 CRP ALB

Graphical network of the top 20 diseases related to Obstructive Jaundice:

Diseases related to Obstructive Jaundice

Symptoms & Phenotypes for Obstructive Jaundice

UMLS symptoms related to Obstructive Jaundice:

icterus, jaundice (not of newborn)

MGI Mouse Phenotypes related to Obstructive Jaundice:

# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.25 ALB CEACAM1 CLDN4 CRP EDN1 F2
2 homeostasis/metabolism MP:0005376 10.25 ABCC2 ALB CEACAM1 CLDN4 CRP EDN1
3 growth/size/body region MP:0005378 10.18 CEACAM1 CLDN4 EDN1 F2 GGT1 GPBAR1
4 digestive/alimentary MP:0005381 10.06 ALB CEACAM1 EDN1 F2 IL6 KIT
5 immune system MP:0005387 10 ALB CEACAM1 CRP F2 GGT1 GPBAR1
6 liver/biliary system MP:0005370 9.76 ABCC2 ALB GPBAR1 IL6 KIT SLC25A13
7 muscle MP:0005369 9.56 ALB CEACAM1 EDN1 IL6 KIT REN
8 renal/urinary system MP:0005367 9.4 ABCC2 ALB CLDN4 EDN1 GGT1 GPBAR1

Drugs & Therapeutics for Obstructive Jaundice

Drugs for Obstructive Jaundice (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 85)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Lactulose Approved Phase 4 4618-18-2 11333
Ceftriaxone Approved Phase 4 73384-59-5 5361919 5479530
Levofloxacin Approved, Investigational Phase 4 100986-85-4 149096
Ofloxacin Approved Phase 4 82419-36-1 4583
5 Anti-Bacterial Agents Phase 4
6 Antibiotics, Antitubercular Phase 4
7 Cytochrome P-450 Enzyme Inhibitors Phase 4
8 Anti-Infective Agents Phase 4
Trioxsalen Approved Phase 2, Phase 3 3902-71-4 5585
Nicotinamide Approved, Investigational Phase 3 98-92-0 936
Folic acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
Niacin Approved, Investigational, Nutraceutical Phase 3 59-67-6 938
Methionine Approved, Nutraceutical Phase 3 63-68-3 6137
14 Dihematoporphyrin Ether Phase 2, Phase 3
15 Hematoporphyrin Derivative Phase 2, Phase 3
16 Trace Elements Phase 3
17 Micronutrients Phase 3
18 Vitamins Phase 3
19 Vitamin B Complex Phase 3
20 Nicotinic Acids Phase 3
21 Vitamin B3 Phase 3
22 Vasodilator Agents Phase 3
23 Folate Phase 3
24 Lipid Regulating Agents Phase 3
25 Nutrients Phase 3
26 Hypolipidemic Agents Phase 3
27 Vitamin B9 Phase 3
28 Antimetabolites Phase 3
Neostigmine Approved, Vet_approved Phase 1, Phase 2 59-99-4 4456
Ursodeoxycholic acid Approved, Investigational Phase 2 128-13-2 31401
Disulfiram Approved Phase 2 97-77-8 3117
Copper Approved, Investigational Phase 2 7440-50-8 27099
Ethanol Approved Phase 2 64-17-5 702
Temoporfin Approved, Investigational Phase 2 122341-38-2
35 Cholinergic Agents Phase 1, Phase 2
36 Cholinesterase Inhibitors Phase 1, Phase 2
37 Gastrointestinal Agents Phase 2
38 Photosensitizing Agents Phase 2
39 Dermatologic Agents Phase 2
40 Copper Supplement Phase 2
41 Omega 3 Fatty Acid Phase 1, Phase 2
42 Olive Phase 1, Phase 2
43 Fat Emulsions, Intravenous Phase 1, Phase 2
44 Soy Bean Phase 1, Phase 2
Bilirubin Phase 1, Phase 2 69853-43-6, 635-65-4 21252250 5280352
Methylene blue Approved, Investigational Phase 1 61-73-4
Norepinephrine Approved Phase 1 51-41-2 439260
48 Neurotransmitter Agents Phase 1
49 Mitogens Phase 1
50 Analgesics, Opioid Phase 1

Interventional clinical trials:

(show top 50) (show all 88)
# Name Status NCT ID Phase Drugs
1 Distal Malignant Biliary Obstruction: A Prospective Randomised Trial Comparing Metal and Plastic Stents in Palliation of Symptomatic Jaundice Unknown status NCT00731419 Phase 4
2 Prospective Evaluation of Stent Patency in Patients With Benign Biliary Obstruction of the Wing Biliary Stent (Viaduct™) Unknown status NCT01818050 Phase 4
3 Phase 4 Study :Human Kidney Histopathology in Acute Obstructive Jaundice: a Prospective Study Completed NCT01090193 Phase 4
4 Re-intervention for Occluded Biliary Metal Stent in Malignant Distal Bile Duct Obstruction: a Prospective Randomized Multi-center Trial Comparing Covered and Uncovered Metal Stent Completed NCT01315522 Phase 4
5 Randomized Trial of Short Antibiotic Course to Decrease Post ERCP Cholangitis Recruiting NCT03087656 Phase 4 Ceftriaxone;Levofloxacin
6 Preoperative Biliary Drainage for the Lower Malignant Obstructive Jaundice: A Phase III, Randomized, Controlled, Single Center Study. Unknown status NCT01744938 Phase 3
7 Open-label Observational Study of Plastic Cylindrical Fiber Optic Diffuser (Pioneer Optics) in Photodynamic Therapy for the Management of Cholangiocarcinoma. Unknown status NCT01755013 Phase 2, Phase 3
8 Effect of Palliative Biliary Stenting Versus Conservative Treatment on the Quality of Life (QOL) of Patients With Unresectable Carcinoma of the Gallbladder With Hiliar Block: A Randomised Controlled Trial Completed NCT00391183 Phase 2, Phase 3
9 A Multicenter, Double-Blind, Placebo-Controlled, Randomized Trial of Efficacy and Safety of Remaxol®, a Solution for Intravenous Infusions Produced by STPF "POLYSAN" (Russia), in Patients With Mechanical Jaundice of Non-Malignant Origin Recruiting NCT03418935 Phase 3 Remaxol (succinate + methionine + inosine + nicotinamide);Ringer's Solution
10 A Multicenter, Double-blind, Placebo-controlled, Randomized Trial of the Efficacy and Safety of Remaxol®, a Solution for Infusions Produced by STPF POLYSAN (Russia), in Patients With Malignant Mechanical Jaundice Recruiting NCT03416062 Phase 3 Remaxol®;Ringer's Solution
11 Comparison Between Two Methods of Bilateral Stenting for Malignant Hilar Obstruction Withdrawn NCT01622803 Phase 3
12 The Prevention and Treatment of SIRS in Patients With Cholestatic Jaundice After Operation. Unknown status NCT02279147 Phase 1, Phase 2 neostigmine methylsulfate,raceanisodamine hydrochloride
13 The Effect of Ursodeoxycholic Acid in Liver Functional Restoration of Patients With Obstructive Jaundice After Endoscopic or Surgical Treatment Unknown status NCT01688375 Phase 2 Ursodeoxycholic Acid
14 A Double Blind, Randomized Controlled Prospective Trial of Endo-biliary Radio-frequency Ablation for Maintenance of Metal Stent Patency in Patients With Malignant Obstructive Jaundice Unknown status NCT01275768 Phase 1, Phase 2
15 Evaluation of Preoperative Biliary Drainage on Outcome of Pancreatoduodenectomy: A Multicenter Randomized Controlled Study Unknown status NCT01941342 Phase 2
16 Self Expanding Metal Stents (SEMS) or Plastic Stents to Relieve Obstruction of Obstructive Jaundice Prior to Resection of Periampullary Tumors. Completed NCT02166840 Phase 2
17 Investigation of the Effect of Intraductal Radiofrequency Ablation in Inoperable Biliopancreatic Tumors Complicated With Obstructive Jaundice Completed NCT02468076 Phase 2
18 Phase 2 Study of Randomized Controlled Trial of Pancreatic Enzyme Supplementation in Patients With Unresectable Pancreatic Cancer Completed NCT01587534 Phase 2 Norzyme
19 Phase II Open Labeled Trial of Disulfiram With Copper in Metastatic Breast Cancer Recruiting NCT03323346 Phase 2 Disulfiram
20 Safety and Tumoricidal Effect of Low Dose Temoporfin Photodynamic Therapy in Patients With Inoperable Bile Duct Cancers (Foscan® Study) Recruiting NCT03003065 Phase 2 Temoporfin
21 Compassionate Use of an Intravenous Fat Emulsion Comprised of Soy Oil, Medium Chain Triglycerides, Olive Oil, and Fish Oil for Neonates With Parenteral Nutrition Induced Liver Injury Terminated NCT02721277 Phase 1, Phase 2 SMOFlipid
22 Treatment of Unresectable Hepatocellular Cancer With Opioid Growth Factor: a Phase I Study Completed NCT00706576 Phase 1 Infusion of opioid growth factor
23 Effect of Methylene Blue on Perioperative Organ Function in Patients With Obstructive Jaundice Enrolling by invitation NCT04109859 Phase 1 Saline;Methylene Blue
24 The Preventive Effects of Pre-treatment With Methylene Blue for Vascular Paralysis of the Patients With Obstructive Jaundice During Operation Unknown status NCT03406676 Methylene Blue
25 The Role of Cholangioscopy and Biliary Radio Frequency Ablation in the Management of Occluded Biliary Self-expanding Metal Stent. Unknown status NCT03133026
26 Quorum Sensing Signal Molecules (QSSMs) and Immune Dysfunction in Patients Undergoing Endoscopic Retrograde Cholangiopancreatography (ERCP) for Obstructive Jaundice Unknown status NCT01367821
27 Endoscopic Retrograde Cholangiopancreatography, Endoscopic Ultrasound and Interventional Endoscopy in Pancreatico-biliary, Gastrointestinal and Esophageal Disorders Unknown status NCT01438385
28 Impaired T-Lymphocyte Proliferative Function in Biliary Atresia Children With Prolonged Jaundice Unknown status NCT00155194
29 Endoscopic Access Loop With Bilio-enteric Anastomosis: A Prospective Randomized Comparison Between Gastric and Subcutaneous Accesses Unknown status NCT03252379
30 Comparison Between Fully Covered and Partially Covered Self-expandable Metal Stents With Anti-migration System for Malignant Distal Biliary Obstruction Unknown status NCT02255669
31 Clinical Study of Abdominal Drainage in Laparoscopic Common Bile Duct Exploration With Primary Closure Unknown status NCT03120754
32 The Necessity of Bile Cultures in Patients With Acute Cholangitis Unknown status NCT02601417
33 Percutaneous Transhepatic Cholangiography Versus Endoscopic Ultrasound Guided Biliary Drainage in Advanced Biliary Tract Malignancy That Failed ERCP (PETRUS Study): A Randomized Pilot Study Unknown status NCT01686425
34 Feeding Tolerance in Preterm Infants: Randomized Trial of Bolus Feeding Every 4 Hours Versus Every 3 Hours Unknown status NCT00450697
35 Endoscopic Ultrasound-Guided Biliary Drainage (EUS-BD) Compared to Standard Transpapillary Biliary Drainage (ERCP-TP) for Palliation of Jaundice in Unresectable Cancer of the Head of the Pancreas (BILPAL TRIAL) Unknown status NCT03063554
36 Comparison Between Endoscopic Stenting and Cholecystojejunostomy for PreoperativeDrainage Before Pancreaticoduodenectomy Unknown status NCT01913275
37 Pancreatoduodenectomy With Mesopancreas Dissection.A Prospective Study Comparing Artery-first Approach Versus Standard Approach Unknown status NCT03224832
38 Multicenter Prospective Randomized Controlled Trial of the Nitinol ZILVER Expandable Endoprosthesis in the Palliation of Extrahepatic Malignant Biliary Obstruction Completed NCT00196105
39 Prospective Study on the Comparison Between the Clinicopathological Outcomes According to the Methods of Preoperative Biliary Drainage in Periampullary Cancers Causing Obstructive Jaundice Completed NCT01134276
40 A Double-blind, Randomized, Controlled Trial of Air Insufflation Versus Carbon Dioxide Insufflation During Endoscopic Retrograde Cholangiopancreatography (ERCP). Completed NCT01321203
41 Safety and Efficacy of n-3 Fatty Acid-based Parenteral Nutrition in Patients With Obstructive Jaundice: A Propensity-matched Study Completed NCT03376945 trail cohort;control cohort
42 Observational Study for Safety and Efficacy of Photodynamic Therapy for Bile Duct Invasion of Hepatocellular Carcinoma Completed NCT01506115 Photofrin
43 Endoscopic Ultrasound Evaluation of the Common Bile Duct in Patients With Obstructive Jaundice Due to Bilio-Pancreatic Malignancies: A Multicenter Prospective Study Completed NCT03494023
44 Biliary Cannulation During Endoscopic Retrograde Cholangiopancreatography: Precut Versus Conventional Cannulation. A Prospective Randomized Study Completed NCT02477228
45 Endoscopic Ultrasound-guided Biliary Drainage for Malignant Biliary Obstruction After Failed ERCP: a Single Italian Center Experience Completed NCT03510754
46 Endoscopic Versus Percutaneous Biliary Drainage For Hilar Block Due to Carcinoma Gall Bladder: A Randomized Prospective Trial and Quality Of Life Assessment Completed NCT00409864
47 Biliary Atresia, Hepatic Buffer Response and Sevoflurane Completed NCT02471209 Sevoflurane
48 Study of Stent Insertion Combined With or Without Brachytherapy in Patients With Inoperable Malignant Biliary Obstruction Completed NCT02001779
49 Early Versus Late Cholecystectomy After Clearance of Common Bile Duct Stones by Endoscopic Retrograde Cholangiopancreatography Completed NCT02460315
50 Predicting Acute-on-Chronic Liver Failure in Cirrhosis (PREDICT) Study Completed NCT03056612

Search NIH Clinical Center for Obstructive Jaundice

Cochrane evidence based reviews: jaundice, obstructive

Genetic Tests for Obstructive Jaundice

Anatomical Context for Obstructive Jaundice

MalaCards organs/tissues related to Obstructive Jaundice:

Liver, Pancreas, Testes, Kidney, Lung, Lymph Node, Colon

Publications for Obstructive Jaundice

Articles related to Obstructive Jaundice:

(show top 50) (show all 7308)
# Title Authors PMID Year
[Analysis of tear enzymes in the diagnosis of obstructive jaundice associated with subhepatic cholestasis]. 54 61
19143075 2008
CEA, CA 19-9, and CA 125 in the differential diagnosis of benign and malignant pancreatic diseases with or without jaundice. 61 54
17262731 2007
Contrasting liver function test patterns in obstructive jaundice due to biliary strictures [corrected] and stones. 54 61
15625352 2005
[Clinical study on the changes of growth hormone/insulin-like growth factor-I axis in patient with obstructive jaundice]. 61 54
11702667 2001
Factors predicting nutritional derangements in patients with obstructive jaundice: multivariate analysis. 61 54
11344390 2001
Activity of class I and II isoenzymes of alcohol dehydrogenase measured by a fluorometric method in the sera of patients with obstructive jaundice. 61 54
9247733 1997
Clinical values of CA19-9, CA125 and CEA in malignant obstructive jaundice. 54 61
7634181 1995
Discrepancies between lipoprotein(a) concentrations in icteric sera measured by immunonephelometry and electroimmunodiffusion. 54 61
8200119 1994
T-lymphocyte transformation in experimental obstructive jaundice: the role of serum-suppressive factors. 61 54
8109118 1993
Role of endogenous bile on basal and postprandial CCK release in humans. 54 61
8391974 1993
Human lymphocyte responsiveness is not enhanced by relief of biliary obstruction: an in-vitro study. 61 54
2025801 1991
Bile acids in human plasma interfere with cholecystokinin bioassay using dispersed pancreatic acini. 61 54
1995267 1991
[Reduction of erythrocyte membrane band 4.2 protein in patients with obstructive jaundice]. 54 61
2255052 1990
A combination of raised serum AST:ALT ratio and erythrocyte mean cell volume level detects excessive alcohol consumption. 61 54
2342668 1990
A case of peribiliary hepatic cysts in a cirrhotic liver: A mimicker of Klatskin Tumor. 61
32435324 2020
N-acetyl cysteine treatment mitigates biomarkers of oxidative stress in different tissues of bile duct ligated rats. 61
32510264 2020
Distribution of the organic anion transporters Oat1 and Oat3 between renal membrane microdomains in obstructive jaundice. 61
32451678 2020
European Guideline on IgG4-related digestive disease - UEG and SGF evidence-based recommendations. 61
32552502 2020
A Rare Cause of Obstructive Jaundice: Is Surgery the Only Option? 61
31945361 2020
The Lymphocyte-to-monocyte Ratio Is an Independent Prognostic Indicator in Pancreatic Head Cancer that Correlates With Obstructive Jaundice. 61
32487633 2020
Level of total bilirubin in the bile of the future remnant liver of patients with obstructive jaundice undergoing hepatectomy predicts postoperative liver failure. 61
32506707 2020
Two elder cases of hepatocellular carcinoma adjacent to intrahepatic vessels successfully treated by carbon ion radiotherapy. 61
32529487 2020
Prediction Efficacy for Clinical Outcome of Prognostic Nutritional Index in Patients with Resectable Biliary Tract Cancer Depends on Sex and Obstructive Jaundice Status. 61
32548755 2020
Biliary Ascariasis: An Unusual Case of Obstructive Jaundice. 61
30710698 2020
Langerhans cell histiocytosis confined to extrahepatic bile duct causing sclerosing cholangitis in child: a case report. 61
32548778 2020
Spontaneous lymphocele presenting with obstructive jaundice. 61
31866315 2020
Obstructive jaundice secondary to duodenal diverticulum (Lemmel's syndrome). 61
32389389 2020
A serious complicatıon of liver hydatid cysts in children: cystobiliary fistulas. 61
32206892 2020
Endometrial clear cell carcinoma with metastasis to the common hepatic duct: A rare aetiology of obstructive jaundice, diagnosed by biliary cytology brushing specimen. 61
32049406 2020
Endoscopic ultrasound-guided hepaticogastrostomy for intraductal papillary neoplasm of bile duct with obstructive jaundice and cholangitis due to mucus overproduction. 61
32285967 2020
Efficacy and Safety of Sorafenib in Unresectable Hepatocellular Carcinoma with Bile Duct Invasion. 61
32434180 2020
A direct peroral cholangioscopy-assisted therapy for a choledochojejunostomy anastomotic stricture via EUS-guided hepaticogastrostomy. 61
32462809 2020
A unusual case of multifocal pyogenic abscess formation following ERCP procedure. 61
32375832 2020
[Recent Updates of Immunoglobulin G4-related Pancreatobiliary Disease]. 61
32448857 2020
Diagnostic accuracy of ultrasound in evaluation of obstructive jaundice with MRCP as gold standard. 61
32494250 2020
Utilization of a new technology of 3D biliary CT for ERCP-related procedures: a case report. 61
32448154 2020
A Rare Association With Obstructive Jaundice. 61
31738922 2020
Preoperative biliary drainage of severely obstructive jaundiced patients decreases overall postoperative complications after pancreaticoduodenectomy: A retrospective and propensity score-matched analysis. 61
32107192 2020
Risk factors and management of different types of biliary injuries in blunt abdominal trauma: Single-center retrospective cohort study. 61
32211187 2020
Early malfunction of a biliary self-expandable metal stent with an antireflux valve: A case report. 61
32311973 2020
Cost Analysis of Biliary Drainage Using Metal versus Plastic Stents in Hepatocellular Carcinoma Patients with Obstructive Jaundice. 61
32399460 2020
Rotavirus Reassortant-Induced Murine Model of Liver Fibrosis Parallels Human Biliary Atresia. 61
31442322 2020
Obstructive jaundice caused by ulcerative duodenal stenosis: A case report. 61
32246671 2020
Multiple myeloma presenting as plasmacytoma causing obstructive jaundice. 61
32313483 2020
Health-Related Quality of Life evaluation in "left" versus "right" access for percutaneous transhepatic biliary drainage using EORTC QLQBIL-21 questionnaire: a randomized controlled trial. 61
31327040 2020
Lemmel's Syndrome: Usual Presentation of an Unusual Diagnosis. 61
32431977 2020
Hepatopancreatoduodenectomy for Multifocal Cholangiocarcinoma in the Setting of Biliary Papillomatosis. 61
32248378 2020
IgG4-related Sclerosing Cholangitis Mimicking Cholangiocarcinoma Diagnosed by Endoscopic Ultrasound-guided Fine-needle Aspiration. 61
31875638 2020
Obstructive jaundice caused by postsplenectomy cavernous transformation of the portal vein mimicking cholangiocarcinoma. 61
32320697 2020
De novo perihilar cholangiocarcinoma arising in the allograft liver 15 years post-transplantation for biliary atresia. 61
32350971 2020

Variations for Obstructive Jaundice

Expression for Obstructive Jaundice

Search GEO for disease gene expression data for Obstructive Jaundice.

Pathways for Obstructive Jaundice

Pathways related to Obstructive Jaundice according to GeneCards Suite gene sharing:

(show all 24)
# Super pathways Score Top Affiliating Genes
Show member pathways
2 12.23 TNF TLR4 IL6 CXCL8
Show member pathways
12.17 TNF TLR4 IL6 CXCL8
4 12.14 TNF TLR4 IL6 CXCL8
Show member pathways
12.09 TNF TLR4 IL6 CXCL8
Show member pathways
7 11.92 TNF TLR4 IL6 CXCL8
8 11.9 TNF TLR4 IL6 CXCL8
10 11.79 TNF TLR4 IL6 CXCL8
11 11.76 TNF IL6 EDN1 CXCL8
12 11.72 TNF TLR4 IL6 F2 CXCL8 CLDN4
13 11.7 TNF TLR4 IL6 CXCL8
14 11.66 TNF KIT IL6
15 11.59 TNF TLR4 IL6 CXCL8
Show member pathways
11.58 TNF IL6 CXCL8
17 11.47 TNF IL6 EDN1 CXCL8
18 11.44 TNF IL6 CXCL8
19 11.38 TTR F2 ALB
20 11.38 TNF TLR4 IL6 CXCL8
21 11.27 TNF TLR4 IL6
22 11.26 TNF TLR4 IL6 CXCL8
23 11.18 TNF IL6 ABCC2
24 10.2 TNF IL6 CXCL8 CRP

GO Terms for Obstructive Jaundice

Cellular components related to Obstructive Jaundice according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.76 TNF TLR4 SLC25A13 SLC17A5 KIT CLDN4
2 cell surface GO:0009986 9.73 TNF TLR4 KIT CEACAM1 ALPP ABCC2
3 extracellular region GO:0005576 9.65 TTR TNF REN IL6 F2 EDN1
4 extracellular space GO:0005615 9.4 TTR TNF REN KIT IL6 GPT

Biological processes related to Obstructive Jaundice according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.97 TNF TLR4 KIT IL6 CRP
2 cellular protein metabolic process GO:0044267 9.87 TTR IL6 F2 ALB
3 inflammatory response GO:0006954 9.8 TNF TLR4 KIT IL6 CXCL8 CRP
4 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.73 TNF KIT IL6
5 positive regulation of DNA-binding transcription factor activity GO:0051091 9.73 TNF KIT IL6 EDN1
6 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.71 TNF TLR4 EDN1
7 positive regulation of MAP kinase activity GO:0043406 9.7 TNF KIT EDN1
8 positive regulation of smooth muscle cell proliferation GO:0048661 9.69 TNF IL6 EDN1
9 positive regulation of interleukin-6 production GO:0032755 9.67 TNF TLR4 IL6
10 positive regulation of nitric oxide biosynthetic process GO:0045429 9.65 TNF TLR4 EDN1
11 cellular response to lipopolysaccharide GO:0071222 9.65 TNF TLR4 IL6 CXCL8 ABCC2
12 acute-phase response GO:0006953 9.63 IL6 F2 CRP
13 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.58 TNF TLR4 IL6
14 thyroid hormone transport GO:0070327 9.55 TTR ABCC2
15 response to lipopolysaccharide GO:0032496 9.55 TLR4 REN GGT1 EDN1 ABCC2
16 positive regulation of chemokine production GO:0032722 9.54 TNF TLR4 IL6
17 negative regulation of lipid storage GO:0010888 9.13 TNF IL6 CRP
18 positive regulation of JAK-STAT cascade GO:0046427 8.92 TNF KIT IL6 F2

Molecular functions related to Obstructive Jaundice according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.26 TNF IL6 EDN1 CXCL8
2 identical protein binding GO:0042802 9.23 TTR TNF TLR4 SLC25A13 CRP CLDN4

Sources for Obstructive Jaundice

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
54 Novoseek
57 OMIM via Orphanet
61 PubMed
70 Tocris
72 UMLS via Orphanet
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