CON
MCID: OBS082
MIFTS: 44

Obstructive Nephropathy (CON)

Categories: Nephrological diseases

Aliases & Classifications for Obstructive Nephropathy

MalaCards integrated aliases for Obstructive Nephropathy:

Name: Obstructive Nephropathy 12 15
Con 12 75
Congenital Obstructive Nephropathy 12
Nephropathy Obstructive 55

Classifications:



External Ids:

Disease Ontology 12 DOID:0070314

Summaries for Obstructive Nephropathy

Disease Ontology : 12 A kidney disease characterized by kidney damage and dysfunction resulting from urinary tract obstruction.

MalaCards based summary : Obstructive Nephropathy, also known as con, is related to renal fibrosis and acute kidney failure. An important gene associated with Obstructive Nephropathy is SKIL (SKI Like Proto-Oncogene), and among its related pathways/superpathways are Metabolism of proteins and TGF-Beta Pathway. The drugs Acetylcysteine and carbamide peroxide have been mentioned in the context of this disorder. Affiliated tissues include kidney, endothelial and bone, and related phenotypes are homeostasis/metabolism and growth/size/body region

Related Diseases for Obstructive Nephropathy

Diseases related to Obstructive Nephropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 766)
# Related Disease Score Top Affiliating Genes
1 renal fibrosis 30.7 TGFB1 SMAD3 SMAD2 REN HGF
2 acute kidney failure 30.4 REN HGF ALB
3 urinary tract obstruction 30.2 TGFB1 SMAD3 SMAD2 REN ALB
4 multicystic dysplastic kidney 30.2 REN AGTR2
5 end stage renal failure 29.9 TGFB1 ALB AGT ACE
6 heart valve disease 29.9 TGFB1 REN ACE
7 hypertrophic scars 29.8 TGFB1 SMAD3 SMAD2
8 liver cirrhosis 29.8 TGFB1 REN HGF ALB
9 vesicoureteral reflux 1 29.7 REN AGTR2 AGT
10 aortic valve disease 1 29.6 TGFB1 REN ACE
11 posterior urethral valves 29.6 TGFB1 AGTR2 AGT ACE
12 obstructive jaundice 29.6 REN HGF ALB
13 microvascular complications of diabetes 3 29.4 ALB AGT ACE
14 iga glomerulonephritis 29.4 TGFB1 REN ALB ACE
15 anuria 29.3 REN ALB AGT ACE
16 renal dysplasia 29.3 REN AGT ACE
17 arteries, anomalies of 29.3 REN ALB AGT ACE
18 malignant hypertension 29.2 REN AGT ACE
19 pulmonary fibrosis, idiopathic 29.0 TGFB1 SMAD3 SMAD2 HGF AGT
20 kidney disease 28.9 TGFB1 REN ALB AGTR2 AGT ACE
21 hypertension, essential 28.6 REN ALB AGTR2 AGT ACE
22 autosomal dominant polycystic kidney disease 28.6 REN ALB AGT ACE
23 myocardial infarction 28.4 REN ALB AGTR2 AGT ACE
24 interstitial nephritis 28.2 TINAG REN ALB AGT ACE
25 dilated cardiomyopathy 27.9 TGFB1 REN ALB AGT ACE
26 pik3ca-related overgrowth syndrome 11.2
27 ureteral obstruction 10.8
28 fibrosis of extraocular muscles, congenital, 1 10.5
29 hydronephrosis 10.5
30 hypoaldosteronism 10.4 REN ACE
31 chronic kidney disease 10.4
32 renal artery obstruction 10.4 REN ACE
33 loeffler syndrome 10.3 ALB ACE
34 familial vesicoureteral reflux 10.3 TGFB1 AGTR2 ACE
35 nephrogenic systemic fibrosis 10.3 TGFB1 SMAD3 SMAD2
36 malignant secondary hypertension 10.3 REN AGTR2
37 benign essential hypertension 10.3 REN ALB
38 kidney papillary necrosis 10.3 REN ALB
39 congenital anomalies of kidney and urinary tract 2 10.2
40 malignant essential hypertension 10.2 REN AGTR2 ACE
41 cardiac arrest 10.2
42 acute kidney tubular necrosis 10.2 HGF HAVCR1 ALB
43 pseudohyperkalemia, familial, 2, due to red cell leak 10.2 REN AGTR2 ACE
44 biliary atresia 10.2 TGFB1 HGF ALB
45 hypertensive encephalopathy 10.1 REN ACE
46 lung cancer 10.1
47 autoimmune disease 10.1
48 multiple sclerosis 10.1
49 pain agnosia 10.1
50 pediatric hypertension 10.1 AGT ACE

Graphical network of the top 20 diseases related to Obstructive Nephropathy:



Diseases related to Obstructive Nephropathy

Symptoms & Phenotypes for Obstructive Nephropathy

MGI Mouse Phenotypes related to Obstructive Nephropathy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.15 ACE AGT AGTR2 ALB CLU GFER
2 growth/size/body region MP:0005378 10.14 ACE AGT AGTR2 GFER HGF REN
3 cardiovascular system MP:0005385 10.09 ACE AGT AGTR2 CLU HGF REN
4 immune system MP:0005387 10.02 ACE AGT CLU GFER REN SKIL
5 mortality/aging MP:0010768 9.9 ACE AGT AGTR2 ALB GFER HGF
6 liver/biliary system MP:0005370 9.86 ACE AGT ALB GFER HGF SMAD2
7 neoplasm MP:0002006 9.56 ACE AGTR2 ALB GFER SKIL SMAD2
8 renal/urinary system MP:0005367 9.23 ACE AGT AGTR2 ALB CLU REN

Drugs & Therapeutics for Obstructive Nephropathy

Drugs for Obstructive Nephropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcysteine Approved, Investigational 616-91-1 12035
2
carbamide peroxide Approved 124-43-6
3 Respiratory System Agents
4 Antidotes
5 Antioxidants
6 Free Radical Scavengers
7 Anti-Infective Agents
8 N-monoacetylcystine
9 Protective Agents
10 Expectorants
11 Antiviral Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Does Ultra-High Dose i.v. N-acetylcysteine Prevent Contrast Nephropathy in Patients With Chronic Kidney Disease Undergoing Emergency Contrast Tomography. Completed NCT01467154
2 Measurement of Renal Artery Resistive Index as a Predictor of Severity of Lupus Nephritis and Its Response to Treatment Not yet recruiting NCT03958851

Search NIH Clinical Center for Obstructive Nephropathy

Genetic Tests for Obstructive Nephropathy

Anatomical Context for Obstructive Nephropathy

MalaCards organs/tissues related to Obstructive Nephropathy:

41
Kidney, Endothelial, Bone, Monocytes, Prostate, Liver, Smooth Muscle

Publications for Obstructive Nephropathy

Articles related to Obstructive Nephropathy:

(show top 50) (show all 835)
# Title Authors PMID Year
1
Hepatocyte growth factor exerts its anti-inflammatory action by disrupting nuclear factor-kappaB signaling. 9 38
18502824 2008
2
Species differences in renal Src activity direct EGF receptor regulation in life or death response to EGF. 9 38
17626154 2007
3
Molecular basis for the cell type specific induction of SnoN expression by hepatocyte growth factor. 9 38
17625116 2007
4
Biochemical-molecular markers in unilateral ureteral obstruction. 9 38
17665634 2007
5
Downregulation of SnoN expression in obstructive nephropathy is mediated by an enhanced ubiquitin-dependent degradation. 9 38
16959829 2006
6
Implication of genetic variations in congenital obstructive nephropathy. 9 38
16133060 2005
7
Obstructive nephropathy: insights from genetically engineered animals. 9 38
16105023 2005
8
A novel mechanism by which hepatocyte growth factor blocks tubular epithelial to mesenchymal transition. 9 38
15537870 2005
9
Hepatocyte growth factor gene therapy and angiotensin II blockade synergistically attenuate renal interstitial fibrosis in mice. 9 38
12239235 2002
10
Hepatocyte growth factor suppresses interstitial fibrosis in a mouse model of obstructive nephropathy. 9 38
11260391 2001
11
MCP-1 and EGF renal expression and urine excretion in human congenital obstructive nephropathy. 9 38
10886563 2000
12
Obstructive nephropathy: lessons from cystic kidney disease. 9 38
10644902 2000
13
Increased expression of TGF-beta1 but not of its receptors contributes to human obstructive nephropathy. 9 38
10594789 1999
14
Urinary excretion of beta 2-glycoprotein-1 (apolipoprotein H) and other markers of tubular malfunction in "non-tubular" renal disease. 9 38
1381383 1992
15
Endothelial-specific deletion of Brahma-related gene 1 (BRG1) assuages unilateral ureteral obstruction induced renal injury in mice. 38
31349970 2019
16
Petchiether A attenuates obstructive nephropathy by suppressing TGF-β/Smad3 and NF-κB signalling. 38
31211499 2019
17
Losartan accelerates the repair process of renal fibrosis in UUO mouse after the surgical recanalization by upregulating the expression of Tregs. 38
31401712 2019
18
Diuresis renography in equivocal urinary tract obstruction. A historical perspective. 38
31136948 2019
19
Mechanisms of antimicrobial-induced nephrotoxicity in children. 38
31369087 2019
20
Peritoneal Dialysis Treatment in Small Children with Acute Kidney Injury: Experience in Northwest China. 38
31357204 2019
21
Krt5+ Urothelial Cells are Developmental and Tissue Repair Progenitors in the Kidney. 38
31322419 2019
22
Spectrum of chronic kidney disease in China: A national study based on hospitalized patients from 2010 to 2015. 38
30198082 2019
23
IgG4-related kidney disease (IgG4-RKD) with membranous nephropathy as its initial manifestation: report of one case and literature review. 38
31311519 2019
24
O bladder, where art thou? An unusual cause of obstructive nephropathy. 38
31085624 2019
25
Full age spectrum equation versus CKD-EPI and MDRD equations to estimate glomerular filtration rate in adults with obstructive nephropathy. 38
30991866 2019
26
Unilateral Ureteral Obstruction as a Model to Investigate Fibrosis-Attenuating Treatments. 38
30965656 2019
27
Effect of Quyu Chencuo Formula () on Renal Fibrosis in Obstructive Nephropathy Rats. 38
26142335 2019
28
Obstructive nephropathy: simple yet complicated! 38
30386975 2019
29
Symmetric nephromegaly. 38
30178235 2019
30
Blocking Tyr265 nitration of protein phosphatase 2A attenuates nitrosative stress-induced endothelial dysfunction in renal microvessels. 38
30521379 2019
31
Drug-induced Obstructive and Retrograde Nephropathy Associated with α2u-globulin in Male Rats. 38
30587097 2019
32
A Novel Biomarker for Acute Kidney Injury, Vanin-1, for Obstructive Nephropathy: A Prospective Cohort Pilot Study. 38
30791405 2019
33
Elevated urinary lipocalin-2, interleukin-6 and monocyte chemoattractant protein-1 levels in children with congenital ureteropelvic junction obstruction. 38
30420258 2019
34
Protease-activated receptor-1 contributes to renal injury and interstitial fibrosis during chronic obstructive nephropathy. 38
30485646 2019
35
Tamoxifen ameliorates obstructive nephropathy through Src and the PI3K/Akt/mTOR pathway. 38
30304547 2019
36
Protein kinase C inhibitor chelerythrine attenuates partial unilateral ureteral obstruction induced kidney injury in neonatal rats. 38
30439378 2019
37
Renal Fibrosis, Immune Cell Infiltration and Changes of TRPC Channel Expression after Unilateral Ureteral Obstruction in Trpc6-/- Mice. 38
31099508 2019
38
Shenkang injection, a modern preparation of Chinese patent medicine, diminishes tubulointerstitial fibrosis in obstructive nephropathy via targeting pericyte-myofibroblast transition. 38
31105812 2019
39
The Effect of Arabic Gum on Renal Function in Reversible Unilateral Ureteric Obstruction. 38
30641998 2019
40
Changes in cell fate determine the regenerative and functional capacity of the developing kidney before and after release of obstruction. 38
30442812 2018
41
Renal expression and urinary excretion of Na+/dicarboxylate cotransporter 1 (NaDC1) in obstructive nephropathy: a candidate biomarker for this pathology. 38
30140954 2018
42
Biomarkers of obstructive nephropathy using a metabolomics approach in rat. 38
30339777 2018
43
Ultrasound and color Doppler applications in chronic kidney disease. 38
30191413 2018
44
Dicer deficiency in proximal tubules exacerbates renal injury and tubulointerstitial fibrosis and upregulates Smad2/3. 38
30280598 2018
45
The TGFβ-ERK pathway contributes to Notch3 upregulation in the renal tubular epithelial cells of patients with obstructive nephropathy. 38
30081092 2018
46
Lack of microRNA-155 ameliorates renal fibrosis by targeting PDE3A/TGF-β1/Smad signaling in mice with obstructive nephropathy. 38
30080287 2018
47
Higher Incidence of Renal Allograft Glomerulonephritis in Living-Related Donor Kidney Transplantation. 38
30316370 2018
48
Blood Pressure Variability and Autonomic Dysfunction. 38
30361834 2018
49
S100A8/A9 promotes parenchymal damage and renal fibrosis in obstructive nephropathy. 38
29746703 2018
50
Candidate gene and mechanism investigations in congenital obstructive nephropathy based on bioinformatics analysis. 38
30015886 2018

Variations for Obstructive Nephropathy

Expression for Obstructive Nephropathy

Search GEO for disease gene expression data for Obstructive Nephropathy.

Pathways for Obstructive Nephropathy

Pathways related to Obstructive Nephropathy according to GeneCards Suite gene sharing:

(show all 35)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.69 VNN1 TGFB1 SMAD3 SMAD2 REN GFER
2
Show member pathways
13.32 TGFB1 SMAD3 SMAD2 SKIL PDGFD HGF
3
Show member pathways
12.64 TGFB1 REN PDGFD HGF GFER AGTR2
4
Show member pathways
12.34 TGFB1 SMAD3 SMAD2 PDGFD
5
Show member pathways
12.14 TGFB1 PDGFD HGF GFER
6
Show member pathways
12.13 TGFB1 SMAD3 SMAD2 SKIL
7 12.07 TGFB1 SMAD3 SMAD2 SKIL
8 11.99 SMAD3 SMAD2 SKIL
9
Show member pathways
11.98 TGFB1 SMAD3 SMAD2
10 11.95 TGFB1 HGF ALB
11 11.95 TGFB1 SMAD3 AGT
12
Show member pathways
11.94 TGFB1 SMAD3 SMAD2
13 11.88 TGFB1 SMAD3 SMAD2 SKIL
14 11.86 TGFB1 SMAD3 SMAD2 SKIL
15 11.79 TGFB1 SMAD3 SMAD2
16 11.77 TGFB1 SMAD3 SMAD2
17
Show member pathways
11.75 TGFB1 SMAD3 SMAD2
18 11.73 TGFB1 SMAD3 SMAD2
19 11.72 TGFB1 REN HGF
20 11.64 SMAD3 SMAD2 SKIL
21
Show member pathways
11.63 TGFB1 SMAD3 SMAD2
22 11.61 TGFB1 PDGFD HGF GFER
23
Show member pathways
11.58 TGFB1 SMAD3 SMAD2
24 11.56 REN AGT ACE
25 11.53 TGFB1 SMAD3 SMAD2 SKIL
26 11.53 TGFB1 SMAD3 SMAD2 SKIL
27 11.51 TGFB1 SKIL HGF
28
Show member pathways
11.5 TGFB1 SMAD3 SMAD2
29 11.39 TGFB1 SMAD3 SMAD2 SKIL
30 11.27 TGFB1 SMAD3 SMAD2 SKIL
31
Show member pathways
11.18 TGFB1 SMAD3 SMAD2 SKIL PDGFD HGF
32 10.92 SMAD3 SMAD2
33 10.86 TGFB1 HGF
34 10.84 TGFB1 SMAD3 SMAD2
35 10.73 TGFB1 SMAD3 SMAD2 HGF

GO Terms for Obstructive Nephropathy

Cellular components related to Obstructive Nephropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.81 TINAG TGFB1 REN PDGFD HGF CLU
2 protein-containing complex GO:0032991 9.8 SMAD3 SMAD2 SKIL CLU ALB
3 blood microparticle GO:0072562 9.62 TGFB1 CLU ALB AGT
4 SMAD protein complex GO:0071141 9.37 SMAD3 SMAD2
5 extracellular region GO:0005576 9.36 VNN1 TINAG TGFB1 REN PDGFD HGF
6 heteromeric SMAD protein complex GO:0071144 9.26 SMAD3 SMAD2
7 platelet alpha granule lumen GO:0031093 9.26 TGFB1 HGF CLU ALB

Biological processes related to Obstructive Nephropathy according to GeneCards Suite gene sharing:

(show top 50) (show all 61)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell migration GO:0030335 9.95 TGFB1 SMAD3 PDGFD HGF
2 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.9 TGFB1 CLU AGT
3 cell cycle arrest GO:0007050 9.9 TGFB1 SMAD3 SKIL
4 kidney development GO:0001822 9.88 REN AGT ACE
5 platelet degranulation GO:0002576 9.88 TGFB1 HGF CLU ALB
6 negative regulation of cell growth GO:0030308 9.87 TGFB1 SMAD3 AGTR2 AGT
7 wound healing GO:0042060 9.86 TGFB1 SMAD3 SMAD2
8 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.86 TGFB1 HGF AGT
9 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.83 PDGFD HGF AGT
10 cellular response to transforming growth factor beta stimulus GO:0071560 9.82 TGFB1 SMAD3 PDGFD
11 SMAD protein signal transduction GO:0060395 9.82 TGFB1 SMAD3 SMAD2
12 positive regulation of fibroblast proliferation GO:0048146 9.8 TGFB1 PDGFD AGT
13 positive regulation of epithelial to mesenchymal transition GO:0010718 9.79 TGFB1 SMAD3 SMAD2
14 transforming growth factor beta receptor signaling pathway GO:0007179 9.78 TGFB1 SMAD3 SMAD2 SKIL
15 ureteric bud development GO:0001657 9.77 TGFB1 SMAD3 SMAD2
16 blood vessel remodeling GO:0001974 9.76 AGTR2 AGT ACE
17 regulation of vasoconstriction GO:0019229 9.73 AGT ACE
18 positive regulation of blood pressure GO:0045777 9.73 AGT ACE
19 endoderm development GO:0007492 9.73 TGFB1 SMAD3 SMAD2
20 adrenal gland development GO:0030325 9.72 SMAD3 SMAD2
21 embryonic pattern specification GO:0009880 9.72 SMAD3 SMAD2
22 vasodilation GO:0042311 9.72 AGTR2 AGT
23 signal transduction involved in regulation of gene expression GO:0023019 9.72 SMAD3 SMAD2
24 negative regulation of release of cytochrome c from mitochondria GO:0090201 9.71 HGF CLU
25 nitric oxide mediated signal transduction GO:0007263 9.71 AGTR2 AGT
26 positive regulation of cellular protein metabolic process GO:0032270 9.71 TGFB1 AGT
27 cellular sodium ion homeostasis GO:0006883 9.71 AGTR2 AGT
28 activin receptor signaling pathway GO:0032924 9.71 SMAD3 SMAD2
29 negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 9.71 TGFB1 SMAD3 SMAD2 SKIL
30 positive regulation of superoxide anion generation GO:0032930 9.7 TGFB1 AGT
31 cell growth involved in cardiac muscle cell development GO:0061049 9.7 AGTR2 AGT
32 regulation of blood vessel diameter GO:0097746 9.7 AGTR2 ACE
33 positive regulation of renal sodium excretion GO:0035815 9.69 AGTR2 AGT
34 amyloid-beta metabolic process GO:0050435 9.69 REN ACE
35 angiotensin maturation GO:0002003 9.68 REN ACE
36 response to cholesterol GO:0070723 9.68 TGFB1 SMAD2
37 primary miRNA processing GO:0031053 9.67 SMAD3 SMAD2
38 nodal signaling pathway GO:0038092 9.67 SMAD3 SMAD2
39 pericardium development GO:0060039 9.67 SMAD3 SMAD2
40 embryonic foregut morphogenesis GO:0048617 9.66 SMAD3 SMAD2
41 regulation of protein import into nucleus GO:0042306 9.65 TGFB1 AGTR2
42 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 9.64 AGT ACE
43 common-partner SMAD protein phosphorylation GO:0007182 9.63 TGFB1 SMAD2
44 regulation of transforming growth factor beta receptor signaling pathway GO:0017015 9.63 TGFB1 SMAD3 SMAD2
45 positive regulation of extracellular matrix assembly GO:1901203 9.62 TGFB1 SMAD3
46 regulation of blood pressure GO:0008217 9.62 REN AGTR2 AGT ACE
47 regulation of striated muscle tissue development GO:0016202 9.61 TGFB1 SMAD3
48 negative regulation of neurotrophin TRK receptor signaling pathway GO:0051387 9.61 AGTR2 AGT
49 positive regulation of branching involved in ureteric bud morphogenesis GO:0090190 9.61 TGFB1 AGTR2 AGT
50 regulation of blood volume by renin-angiotensin GO:0002016 9.59 REN AGT

Molecular functions related to Obstructive Nephropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 R-SMAD binding GO:0070412 9.48 SMAD3 SMAD2
2 tau protein binding GO:0048156 9.46 SMAD2 CLU
3 enhancer binding GO:0035326 9.43 SMAD3 SMAD2
4 SMAD binding GO:0046332 9.43 SMAD3 SMAD2 SKIL
5 type I transforming growth factor beta receptor binding GO:0034713 9.4 TGFB1 SMAD2
6 co-SMAD binding GO:0070410 9.37 SMAD3 SMAD2
7 primary miRNA binding GO:0070878 9.32 SMAD3 SMAD2
8 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity GO:0030618 9.16 SMAD3 SMAD2
9 transforming growth factor beta receptor binding GO:0005160 9.13 TGFB1 SMAD3 SMAD2
10 growth factor activity GO:0008083 9.02 TGFB1 PDGFD HGF GFER AGT

Sources for Obstructive Nephropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
Content
Loading form....