CON
MCID: OBS082
MIFTS: 52

Obstructive Nephropathy (CON)

Categories: Nephrological diseases

Aliases & Classifications for Obstructive Nephropathy

MalaCards integrated aliases for Obstructive Nephropathy:

Name: Obstructive Nephropathy 12 15
Con 12 77
Congenital Obstructive Nephropathy 12
Nephropathy Obstructive 56

Classifications:



External Ids:

Disease Ontology 12 DOID:0070314

Summaries for Obstructive Nephropathy

Disease Ontology : 12 A kidney disease characterized by kidney damage and dysfunction resulting from urinary tract obstruction.

MalaCards based summary : Obstructive Nephropathy, also known as con, is related to renal fibrosis and hydronephrosis. An important gene associated with Obstructive Nephropathy is SKIL (SKI Like Proto-Oncogene), and among its related pathways/superpathways are TGF-Beta Pathway and PAK Pathway. The drugs Remifentanil and Midazolam have been mentioned in the context of this disorder. Affiliated tissues include kidney, t cells and liver, and related phenotypes are growth/size/body region and homeostasis/metabolism

Wikipedia : 77 The killdeer (Charadrius vociferus) is a large plover found in the Americas. It was described and given... more...

Related Diseases for Obstructive Nephropathy

Diseases related to Obstructive Nephropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 387)
# Related Disease Score Top Affiliating Genes
1 renal fibrosis 30.5 TGFB1 SMAD3 SMAD2 REN HGF
2 hydronephrosis 30.0 ALB EGF TGFB1
3 kidney disease 29.9 ACE AGT AGTR2 ALB REN TGFB1
4 arteries, anomalies of 29.5 ACE AGT ALB REN
5 iga glomerulonephritis 29.5 ACE ALB REN TGFB1
6 microvascular complications of diabetes 3 29.5 ACE AGT ALB
7 end stage renal failure 29.3 ACE AGT ALB TGFB1
8 pulmonary fibrosis, idiopathic 29.2 AGT HGF SMAD2 SMAD3 TGFB1
9 myocardial infarction 29.1 ACE AGT AGTR2 ALB REN
10 chronic kidney failure 29.0 ACE AGT ALB REN TGFB1
11 large intestine cancer 29.0 ALB EGF HGF SMAD2
12 autosomal dominant polycystic kidney disease 28.6 REN EGF ALB AGT ACE
13 breast reconstruction 11.2
14 degos 'en cocarde' erythrokeratoderma 10.6
15 xp22.3 microdeletion syndrome 10.4
16 pelger-huet anomaly 10.4
17 multicystic dysplastic kidney 10.3 AGTR2 REN
18 hypoaldosteronism 10.3 ACE REN
19 hepatitis 10.3
20 renal artery obstruction 10.2 ACE REN
21 malignant secondary hypertension 10.2 AGTR2 REN
22 loeffler syndrome 10.2 ACE ALB
23 familial vesicoureteral reflux 10.2 ACE AGTR2 TGFB1
24 benign essential hypertension 10.2 ALB REN
25 hypertrophic scars 10.2 SMAD2 SMAD3 TGFB1
26 keloids 10.2 SMAD2 SMAD3 TGFB1
27 nephrogenic systemic fibrosis 10.2 SMAD2 SMAD3 TGFB1
28 kidney papillary necrosis 10.2 ALB REN
29 asthma 10.1
30 hypertension, diastolic 10.1 ACE REN
31 malignant essential hypertension 10.1 ACE AGTR2 REN
32 pediatric hypertension 10.1 ACE AGT
33 heart valve disease 10.1 ACE REN TGFB1
34 acute kidney tubular necrosis 10.1 ALB HAVCR1 HGF
35 biliary atresia 10.1 ALB HGF TGFB1
36 hypertensive encephalopathy 10.1 ACE REN
37 pseudohyperkalemia, familial, 2, due to red cell leak 10.1 ACE AGTR2 REN
38 potter's syndrome 10.1 AGT REN
39 hypertensive retinopathy 10.1 ACE REN
40 burns 10.1 ALB HGF
41 obstructive jaundice 10.1 ALB HGF REN
42 tricuspid valve prolapse 10.1 EGF SMAD3
43 congenital anomalies of kidney and urinary tract 2 10.1 EGF HAVCR1 TGFB1
44 chagas disease 10.1 ACE SMAD2 TGFB1
45 kidney hypertrophy 10.1 ALB TGFB1
46 orthostatic proteinuria 10.1 ACE ALB REN
47 lung cancer 10.1
48 diabetes mellitus 10.1
49 atrial fibrillation 10.1
50 hepatorenal syndrome 10.1 ACE ALB REN

Graphical network of the top 20 diseases related to Obstructive Nephropathy:



Diseases related to Obstructive Nephropathy

Symptoms & Phenotypes for Obstructive Nephropathy

MGI Mouse Phenotypes related to Obstructive Nephropathy:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.17 ACE AGT AGTR2 EGF GFER HGF
2 homeostasis/metabolism MP:0005376 10.14 ACE AGT AGTR2 ALB CLU GFER
3 cardiovascular system MP:0005385 10.13 ACE AGT AGTR2 CLU HGF REN
4 immune system MP:0005387 10.07 ACE AGT CLU EGF GFER REN
5 endocrine/exocrine gland MP:0005379 10.06 ACE AGTR2 ALB EGF SKIL SMAD2
6 mortality/aging MP:0010768 10 ACE AGT AGTR2 ALB GFER HGF
7 liver/biliary system MP:0005370 9.92 ACE AGT ALB GFER HGF SMAD2
8 neoplasm MP:0002006 9.76 ACE AGTR2 ALB GFER SKIL SMAD2
9 renal/urinary system MP:0005367 9.56 ACE AGT AGTR2 ALB CLU REN
10 reproductive system MP:0005389 9.23 ACE AGT EGF REN SKIL SMAD2

Drugs & Therapeutics for Obstructive Nephropathy

Drugs for Obstructive Nephropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Remifentanil Approved Not Applicable 132875-61-7 60815
2
Midazolam Approved, Illicit Not Applicable 59467-70-8 4192
3
Cisatracurium Approved Not Applicable 96946-41-7
4
Sufentanil Approved, Investigational Not Applicable 56030-54-7 41693
5
Sevoflurane Approved, Vet_approved Not Applicable 28523-86-6 5206
6
Propofol Approved, Investigational, Vet_approved Not Applicable 2078-54-8 4943
7
Etomidate Approved Not Applicable 33125-97-2 36339 667484
8 Anesthetics, Intravenous Not Applicable
9 GABA Agents Not Applicable
10 Neurotransmitter Agents Not Applicable
11 Narcotics Not Applicable
12 Tranquilizing Agents Not Applicable
13 Neuromuscular Agents Not Applicable
14 Adjuvants, Anesthesia Not Applicable
15 Peripheral Nervous System Agents Not Applicable
16 Central Nervous System Depressants Not Applicable
17 Analgesics Not Applicable
18 GABA Modulators Not Applicable
19 Anesthetics, General Not Applicable
20 Neuromuscular Blocking Agents Not Applicable
21 Hypnotics and Sedatives Not Applicable
22 Psychotropic Drugs Not Applicable
23 Anesthetics Not Applicable
24 Anti-Anxiety Agents Not Applicable
25 Analgesics, Opioid Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Hemodynamics and Vital Organ Function in Intracerebral Hemorrhage Unknown status NCT03129009 Not Applicable Total intravenous anesthesia group;Balanced anesthesia group

Search NIH Clinical Center for Obstructive Nephropathy

Genetic Tests for Obstructive Nephropathy

Anatomical Context for Obstructive Nephropathy

MalaCards organs/tissues related to Obstructive Nephropathy:

42
Kidney, T Cells, Liver, Testes, Spleen, Lung, Heart

Publications for Obstructive Nephropathy

Articles related to Obstructive Nephropathy:

(show top 50) (show all 2193)
# Title Authors Year
1
Pro-Con Debate: Component resolved diagnostic testing is not useful for making food allergy diagnoses. ( 30772391 )
2019
2
Protease-activated receptor-1 contributes to renal injury and interstitial fibrosis during chronic obstructive nephropathy. ( 30485646 )
2019
3
A Novel Biomarker for Acute Kidney Injury, Vanin-1, for Obstructive Nephropathy: A Prospective Cohort Pilot Study. ( 30791405 )
2019
4
Oligometastatic Prostate Cancer Should Be Studied and Treated Differently to High-volume Disease. Con: The Underlying Biology is the Same, so They Should Not Be Treated Differently. ( 30803925 )
2019
5
Plasma metabolites predict both insulin resistance and incident type 2 diabetes: a metabolomics approach within the Prevención con Dieta Mediterránea (PREDIMED) study. ( 30796776 )
2019
6
Early Integration of Palliative and Oncological Care: Con. ( 30572330 )
2019
7
Con: Modified Ultrafiltration in Pediatric Cardiac Surgery Is No Longer Necessary. ( 30587424 )
2019
8
Glycosylated naphthalimides and naphthalimide Tröger's bases as fluorescent aggregation probes for Con A. ( 30629076 )
2019
9
Correction: Glycosylated naphthalimides and naphthalimide Tröger's bases as fluorescent aggregation probes for Con A. ( 30702731 )
2019
10
Nasal high-flow preoxygenation for endotracheal intubation in the critically ill patient? Con. ( 30747252 )
2019
11
Con: vascular access surveillance in mature fistulas: is it worthwhile? ( 30768169 )
2019
12
Are Slings Still the Gold Standard for Female Stress Urinary Incontinence? Con: Artificial Urinary Sphincter for Female Incontinence. ( 30772361 )
2019
13
Con: OIT is safe/better than food avoidance. ( 30772390 )
2019
14
Effect of early experience on neuronal and behavioral responses to con- and heterospecific odors in closely related Mus taxa: epigenetic contribution in formation of precopulatory isolation. ( 30813903 )
2019
15
Opioid-free anaesthesia: Con: it is too early to adopt opioid-free anaesthesia today. ( 30817360 )
2019
16
Importance of diastolic pressure in septic shock: Con - Response. ( 30826175 )
2019
17
Con: should asymptomatic patients with moderate-to-severe 
OSA be treated? ( 30838055 )
2019
18
Del Nido Cardioplegia Should Be Used in All Adults Undergoing Cardiac Surgery: Con. ( 30852089 )
2019
19
CON: Levosimendan should be used in clinical practice for patients with significantly impaired left ventricular function undergoing cardiac surgery. ( 30857925 )
2019
20
Con: Critical Care Ultrasound Should Not Be a Priority First-Line Assessment Tool in the Management of Neurocritically Ill Patients. ( 30889021 )
2019
21
Con: Hyperoxia Should Not Be Used Routinely in the Management of Cardiopulmonary Bypass. ( 30890393 )
2019
22
Características otorrinolaringológicas en niños con trisomía 21: un estudio de 171 pacientes en el Hospital Infantil de México Federico Gómez. ( 30907388 )
2019
23
Factores asociados con la picadura de alacrán en escolares: estudio transversal en dos comunidades rurales de Guerrero, México. ( 30907390 )
2019
24
Valve-sparing aortic root surgery. CON: remodeling. ( 28918516 )
2019
25
PRO-CON debate: valve sparing aortic root surgery. PRO: reimplantation. ( 29019069 )
2019
26
Conflicts and con-fusions confounding compassion in acute care: Creating dialogical moral space. ( 29281923 )
2019
27
Cryptotanshinone hinders renal fibrosis and epithelial transdifferentiation in obstructive nephropathy by inhibiting TGF-I^1/Smad3/integrin I^1 signal. ( 29928474 )
2018
28
Aplasia cutis congénita con defecto óseo subyacente: evolución favorable tras manejo conservador. ( 30677836 )
2018
29
NOAC in "real world" patients with atrial fibrillation in Italy: results from the ISPAF-2 (Indagine Sicoa Paziente Con Fibrillazione Atriale) survey study. ( 29956065 )
2018
30
Con: Tolvaptan for autosomal dominant polycystic kidney disease-do we know all the answers? ( 30312449 )
2018
31
Ureteral obstructive nephropathy due to compression by intrinsic endometriosis of the ovary. ( 30152447 )
2018
32
Glycyrrhizin alleviates Con A-induced hepatitis by differentially regulating the production of IL-17 and IL-25. ( 30553196 )
2018
33
CD8+ T cell/IL-33/ILC2 axis exacerbates the liver injury in Con A-induced hepatitis in T cell-transferred Rag2-deficient mice. ( 30430216 )
2018
34
Potential Novel Biomarkers of Obstructive Nephropathy in Children with Hydronephrosis. ( 30327688 )
2018
35
Con: Contrast-induced nephropathy-should we try to avoid contrast media in patients with chronic kidney disease? ( 29868835 )
2018
36
Acute obstructive nephropathy in a solitary kidney secondary to massive seminal vesicle cyst. ( 26471897 )
2018
37
Identification of key microRNAs, transcription factors and genes associated with congenital obstructive nephropathy in a mouse model of megabladder. ( 29410288 )
2018
38
Uromodulin deficiency alters tubular injury and interstitial inflammation but not fibrosis in experimental obstructive nephropathy. ( 29595914 )
2018
39
Ginsenoside-Rg1 Protects against Renal Fibrosis by Regulating the Klotho/TGF-β1/Smad Signaling Pathway in Rats with Obstructive Nephropathy. ( 29607931 )
2018
40
Legumain, an asparaginyl endopeptidase, mediates the effect of M2 macrophages on attenuating renal interstitial fibrosis in obstructive nephropathy. ( 29656902 )
2018
41
S100A8/A9 promotes parenchymal damage and renal fibrosis in obstructive nephropathy. ( 29746703 )
2018
42
Hypochlorite modified albumins promote cell death in the tubule interstitium in rats via mitochondrial damage in obstructive nephropathy and the protective effects of antioxidant peptides. ( 29781318 )
2018
43
Candidate gene and mechanism investigations in congenital obstructive nephropathy based on bioinformatics analysis. ( 30015886 )
2018
44
Application of normalized values of kidney clearance function in the diagnosis of bilateral obstructive nephropathy - a preliminary report. ( 30070348 )
2018
45
Lack of microRNA-155 ameliorates renal fibrosis by targeting PDE3A/TGF-β1/Smad signaling in mice with obstructive nephropathy. ( 30080287 )
2018
46
The TGFβ-ERK pathway contributes to Notch3 upregulation in the renal tubular epithelial cells of patients with obstructive nephropathy. ( 30081092 )
2018
47
Renal expression and urinary excretion of Na+/dicarboxylate cotransporter 1 (NaDC1) in obstructive nephropathy: a candidate biomarker for this pathology. ( 30140954 )
2018
48
Tamoxifen ameliorates obstructive nephropathy through Src and the PI3K/Akt/mTOR pathway. ( 30304547 )
2018
49
Biomarkers of obstructive nephropathy using a metabolomics approach in rat. ( 30339777 )
2018
50
Obstructive nephropathy: simple yet complicated! ( 30386975 )
2018

Variations for Obstructive Nephropathy

Expression for Obstructive Nephropathy

Search GEO for disease gene expression data for Obstructive Nephropathy.

Pathways for Obstructive Nephropathy

Pathways related to Obstructive Nephropathy according to GeneCards Suite gene sharing:

(show all 45)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.3 AGT AGTR2 EGF GFER HGF PDGFD
2
Show member pathways
13.22 EGF GFER HGF PDGFD SMAD3 TGFB1
3
Show member pathways
12.98 EGF GFER HGF PDGFD TGFB1
4
Show member pathways
12.79 EGF PDGFD SMAD2 SMAD3 TGFB1
5 12.76 EGF HGF SMAD2 SMAD3 TGFB1
6
Show member pathways
12.68 EGF HGF SMAD2 SMAD3 TGFB1
7
Show member pathways
12.61 EGF GFER HGF PDGFD TGFB1
8
Show member pathways
12.49 ACE AGT AGTR2 EGF GFER HGF
9
Show member pathways
12.4 PDGFD SMAD2 SMAD3 TGFB1
10
Show member pathways
12.31 EGF GFER HGF PDGFD TGFB1
11
Show member pathways
12.21 SKIL SMAD2 SMAD3 TGFB1
12
Show member pathways
12.19 GFER HGF PDGFD TGFB1
13 12.16 SKIL SMAD2 SMAD3 TGFB1
14 12.08 EGF SMAD2 SMAD3 TGFB1
15 12.01 SKIL SMAD2 SMAD3
16 11.99 AGT SMAD3 TGFB1
17
Show member pathways
11.99 EGF SMAD2 SMAD3 TGFB1
18
Show member pathways
11.98 SMAD2 SMAD3 TGFB1
19 11.96 SKIL SMAD2 SMAD3 TGFB1
20 11.96 ALB EGF HGF TGFB1
21 11.95 SKIL SMAD2 SMAD3 TGFB1
22 11.85 SMAD2 SMAD3 TGFB1
23 11.83 SMAD2 SMAD3 TGFB1
24
Show member pathways
11.81 SMAD2 SMAD3 TGFB1
25 11.79 HGF REN TGFB1
26 11.79 SMAD2 SMAD3 TGFB1
27 11.7 SKIL SMAD2 SMAD3
28
Show member pathways
11.65 SMAD2 SMAD3 TGFB1
29 11.64 ACE AGT REN
30 11.62 EGF SMAD3 TGFB1
31 11.62 SKIL SMAD2 SMAD3 TGFB1
32 11.6 SKIL SMAD2 SMAD3 TGFB1
33 11.6 EGF GFER HGF PDGFD TGFB1
34
Show member pathways
11.56 ACE AGT AGTR2 REN TGFB1
35 11.53 EGF HGF SKIL TGFB1
36
Show member pathways
11.49 EGF SMAD2 SMAD3 TGFB1
37 11.44 EGF HGF TGFB1
38 11.41 SKIL SMAD2 SMAD3 TGFB1
39 11.32 EGF SKIL SMAD2 SMAD3 TGFB1
40
Show member pathways
11.24 EGF GFER HGF PDGFD SKIL SMAD2
41 11.1 HGF SMAD2 SMAD3 TGFB1
42 10.96 SMAD2 SMAD3
43 10.95 EGF GFER HGF PDGFD TGFB1
44 10.91 HGF TGFB1
45 10.91 SMAD2 SMAD3 TGFB1

GO Terms for Obstructive Nephropathy

Cellular components related to Obstructive Nephropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.85 ACE AGT ALB CLU EGF HGF
2 protein-containing complex GO:0032991 9.8 ALB CLU SKIL SMAD2 SMAD3
3 blood microparticle GO:0072562 9.62 AGT ALB CLU TGFB1
4 extracellular region GO:0005576 9.4 ACE AGT AGTR2 ALB CLU EGF
5 SMAD protein complex GO:0071141 9.37 SMAD2 SMAD3
6 platelet alpha granule lumen GO:0031093 9.35 ALB CLU EGF HGF TGFB1
7 heteromeric SMAD protein complex GO:0071144 9.26 SMAD2 SMAD3

Biological processes related to Obstructive Nephropathy according to GeneCards Suite gene sharing:

(show top 50) (show all 66)
# Name GO ID Score Top Affiliating Genes
1 cell cycle arrest GO:0007050 9.91 SKIL SMAD3 TGFB1
2 kidney development GO:0001822 9.89 ACE AGT REN
3 negative regulation of cell growth GO:0030308 9.89 AGT AGTR2 SMAD3 TGFB1
4 wound healing GO:0042060 9.88 SMAD2 SMAD3 TGFB1
5 positive regulation of cell migration GO:0030335 9.88 EGF HGF PDGFD SMAD3 TGFB1
6 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.85 AGT HGF PDGFD
7 positive regulation of MAP kinase activity GO:0043406 9.85 EGF PDGFD TGFB1
8 cellular response to transforming growth factor beta stimulus GO:0071560 9.85 PDGFD SMAD3 TGFB1
9 SMAD protein signal transduction GO:0060395 9.84 SMAD2 SMAD3 TGFB1
10 transforming growth factor beta receptor signaling pathway GO:0007179 9.83 SKIL SMAD2 SMAD3 TGFB1
11 positive regulation of fibroblast proliferation GO:0048146 9.82 AGT PDGFD TGFB1
12 positive regulation of epithelial to mesenchymal transition GO:0010718 9.81 SMAD2 SMAD3 TGFB1
13 ureteric bud development GO:0001657 9.8 SMAD2 SMAD3 TGFB1
14 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.8 AGT EGF HGF TGFB1
15 positive regulation of protein tyrosine kinase activity GO:0061098 9.79 ACE AGT EGF
16 blood vessel remodeling GO:0001974 9.77 ACE AGT AGTR2
17 endoderm development GO:0007492 9.76 SMAD2 SMAD3 TGFB1
18 adrenal gland development GO:0030325 9.74 SMAD2 SMAD3
19 positive regulation of blood pressure GO:0045777 9.74 ACE AGT
20 embryonic pattern specification GO:0009880 9.73 SMAD2 SMAD3
21 signal transduction involved in regulation of gene expression GO:0023019 9.73 SMAD2 SMAD3
22 vasodilation GO:0042311 9.73 AGT AGTR2
23 negative regulation of release of cytochrome c from mitochondria GO:0090201 9.73 CLU HGF
24 nitric oxide mediated signal transduction GO:0007263 9.73 AGT AGTR2
25 negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 9.73 SKIL SMAD2 SMAD3 TGFB1
26 regulation of peptidyl-tyrosine phosphorylation GO:0050730 9.72 EGF PDGFD
27 activin receptor signaling pathway GO:0032924 9.72 SMAD2 SMAD3
28 cellular sodium ion homeostasis GO:0006883 9.72 AGT AGTR2
29 positive regulation of cellular protein metabolic process GO:0032270 9.72 AGT TGFB1
30 cell growth involved in cardiac muscle cell development GO:0061049 9.71 AGT AGTR2
31 positive regulation of superoxide anion generation GO:0032930 9.71 AGT TGFB1
32 positive regulation of ubiquitin-dependent protein catabolic process GO:2000060 9.71 CLU EGF
33 amyloid-beta metabolic process GO:0050435 9.71 ACE REN
34 positive regulation of renal sodium excretion GO:0035815 9.71 AGT AGTR2
35 regulation of blood vessel diameter GO:0097746 9.7 ACE AGTR2
36 angiotensin maturation GO:0002003 9.7 ACE REN
37 nodal signaling pathway GO:0038092 9.7 SMAD2 SMAD3
38 primary miRNA processing GO:0031053 9.69 SMAD2 SMAD3
39 response to cholesterol GO:0070723 9.69 SMAD2 TGFB1
40 regulation of transforming growth factor beta receptor signaling pathway GO:0017015 9.69 SMAD2 SMAD3 TGFB1
41 embryonic foregut morphogenesis GO:0048617 9.68 SMAD2 SMAD3
42 pericardium development GO:0060039 9.68 SMAD2 SMAD3
43 regulation of protein import into nucleus GO:0042306 9.68 AGTR2 TGFB1
44 regulation of blood pressure GO:0008217 9.67 ACE AGT AGTR2 REN
45 common-partner SMAD protein phosphorylation GO:0007182 9.66 SMAD2 TGFB1
46 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 9.66 ACE AGT
47 positive regulation of extracellular matrix assembly GO:1901203 9.64 SMAD3 TGFB1
48 negative regulation of neurotrophin TRK receptor signaling pathway GO:0051387 9.63 AGT AGTR2
49 regulation of striated muscle tissue development GO:0016202 9.63 SMAD3 TGFB1
50 positive regulation of branching involved in ureteric bud morphogenesis GO:0090190 9.63 AGT AGTR2 TGFB1

Molecular functions related to Obstructive Nephropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 tau protein binding GO:0048156 9.46 CLU SMAD2
2 enhancer binding GO:0035326 9.43 SMAD2 SMAD3
3 SMAD binding GO:0046332 9.43 SKIL SMAD2 SMAD3
4 co-SMAD binding GO:0070410 9.4 SMAD2 SMAD3
5 type I transforming growth factor beta receptor binding GO:0034713 9.37 SMAD2 TGFB1
6 primary miRNA binding GO:0070878 9.32 SMAD2 SMAD3
7 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity GO:0030618 9.16 SMAD2 SMAD3
8 transforming growth factor beta receptor binding GO:0005160 9.13 SMAD2 SMAD3 TGFB1
9 growth factor activity GO:0008083 9.1 AGT EGF GFER HGF PDGFD TGFB1

Sources for Obstructive Nephropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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