CON
MCID: OBS082
MIFTS: 51

Obstructive Nephropathy (CON)

Categories: Nephrological diseases

Aliases & Classifications for Obstructive Nephropathy

MalaCards integrated aliases for Obstructive Nephropathy:

Name: Obstructive Nephropathy 12 15
Con 12 76
Congenital Obstructive Nephropathy 12
Nephropathy Obstructive 55

Classifications:



External Ids:

Disease Ontology 12 DOID:0070314

Summaries for Obstructive Nephropathy

Disease Ontology : 12 A kidney disease characterized by kidney damage and dysfunction resulting from urinary tract obstruction.

MalaCards based summary : Obstructive Nephropathy, also known as con, is related to renal fibrosis and kidney disease. An important gene associated with Obstructive Nephropathy is SKIL (SKI Like Proto-Oncogene), and among its related pathways/superpathways are TGF-Beta Pathway and PAK Pathway. The drugs Sevoflurane and Remifentanil have been mentioned in the context of this disorder. Affiliated tissues include kidney, liver and lung, and related phenotypes are growth/size/body region and homeostasis/metabolism

Wikipedia : 76 Jean Baptiste Point du Sable (before 1750 ? 1818) is honored as the first permanent non-Native-American... more...

Related Diseases for Obstructive Nephropathy

Diseases related to Obstructive Nephropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 312)
# Related Disease Score Top Affiliating Genes
1 renal fibrosis 30.6 HGF REN SMAD2 SMAD3 TGFB1
2 kidney disease 30.0 ACE AGT AGTR2 ALB REN TGFB1
3 hydronephrosis 30.0 ALB EGF TGFB1
4 aortic valve disease 1 29.7 ACE REN TGFB1
5 microvascular complications of diabetes 3 29.5 ACE AGT ALB
6 arteries, anomalies of 29.4 ACE AGT ALB REN
7 pulmonary fibrosis, idiopathic 29.4 AGT HGF SMAD2 SMAD3 TGFB1
8 iga glomerulonephritis 29.3 ACE ALB REN TGFB1
9 chronic kidney failure 29.2 ACE AGT ALB REN TGFB1
10 myocardial infarction 29.2 ACE AGT AGTR2 ALB REN
11 inflammatory bowel disease 29.0 AGT ALB SMAD2 SMAD3 TGFB1
12 autosomal dominant polycystic kidney disease 28.9 ACE AGT ALB EGF REN
13 breast reconstruction 11.1
14 degos 'en cocarde' erythrokeratoderma 10.6
15 xp22.3 microdeletion syndrome 10.4
16 hepatitis 10.3
17 hyporeninemic hypoaldosteronism 10.2 ACE REN
18 hypoaldosteronism 10.2 ACE REN
19 multicystic dysplastic kidney 10.2 AGTR2 REN
20 renal artery obstruction 10.2 ACE REN
21 pelger-huet anomaly 10.2
22 malignant secondary hypertension 10.2 AGTR2 REN
23 loeffler syndrome 10.2 ACE ALB
24 benign essential hypertension 10.1 ALB REN
25 familial vesicoureteral reflux 10.1 ACE AGTR2 TGFB1
26 hypertrophic scars 10.1 SMAD2 SMAD3 TGFB1
27 keloids 10.1 SMAD2 SMAD3 TGFB1
28 nephrogenic systemic fibrosis 10.1 SMAD2 SMAD3 TGFB1
29 kidney papillary necrosis 10.1 ALB REN
30 asthma 10.1
31 malignant essential hypertension 10.1 ACE AGTR2 REN
32 heart valve disease 10.1 ACE REN TGFB1
33 pediatric hypertension 10.1 ACE AGT
34 pseudohyperkalemia, familial, 2, due to red cell leak 10.1 ACE AGTR2 REN
35 hypertension, diastolic 10.1 ACE REN
36 biliary atresia 10.1 ALB HGF TGFB1
37 potter's syndrome 10.1 AGT REN
38 acute kidney tubular necrosis 10.1 ALB HAVCR1 HGF
39 hypertensive encephalopathy 10.1 ACE REN
40 obstructive jaundice 10.1 ALB HGF REN
41 hypertensive retinopathy 10.1 ACE REN
42 lung cancer 10.1
43 atrial fibrillation 10.1
44 chagas disease 10.1 ACE SMAD2 TGFB1
45 tricuspid valve prolapse 10.1 EGF SMAD3
46 orthostatic proteinuria 10.1 ACE ALB REN
47 congenital anomalies of kidney and urinary tract 2 10.1 EGF HAVCR1 TGFB1
48 kidney hypertrophy 10.0 ALB TGFB1
49 hepatorenal syndrome 10.0 ACE ALB REN
50 renal hypertension 10.0 ACE ALB REN

Graphical network of the top 20 diseases related to Obstructive Nephropathy:



Diseases related to Obstructive Nephropathy

Symptoms & Phenotypes for Obstructive Nephropathy

MGI Mouse Phenotypes related to Obstructive Nephropathy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.17 ACE AGT AGTR2 EGF GFER HGF
2 homeostasis/metabolism MP:0005376 10.14 ACE AGT AGTR2 ALB CLU GFER
3 cardiovascular system MP:0005385 10.13 ACE AGT AGTR2 CLU HGF REN
4 immune system MP:0005387 10.07 ACE AGT CLU EGF GFER REN
5 endocrine/exocrine gland MP:0005379 10.06 ACE AGTR2 ALB EGF SKIL SMAD2
6 mortality/aging MP:0010768 10 ACE AGT AGTR2 ALB GFER HGF
7 liver/biliary system MP:0005370 9.92 ACE AGT ALB GFER HGF SMAD2
8 neoplasm MP:0002006 9.76 ACE AGTR2 ALB GFER SKIL SMAD2
9 renal/urinary system MP:0005367 9.56 ACE AGT AGTR2 ALB CLU REN
10 reproductive system MP:0005389 9.23 ACE AGT EGF REN SKIL SMAD2

Drugs & Therapeutics for Obstructive Nephropathy

Drugs for Obstructive Nephropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sevoflurane Approved, Vet_approved Not Applicable 28523-86-6 5206
2
Remifentanil Approved Not Applicable 132875-61-7 60815
3
Etomidate Approved Not Applicable 33125-97-2 667484 36339
4
Propofol Approved, Investigational, Vet_approved Not Applicable 2078-54-8 4943
5
Sufentanil Approved, Investigational Not Applicable 56030-54-7 41693
6
Cisatracurium Approved Not Applicable 96946-41-7
7
Midazolam Approved, Illicit Not Applicable 59467-70-8 4192
8 GABA Modulators Not Applicable
9 Neuromuscular Blocking Agents Not Applicable
10 Adjuvants, Anesthesia Not Applicable
11 Analgesics Not Applicable
12 Psychotropic Drugs Not Applicable
13 Hypnotics and Sedatives Not Applicable
14 Central Nervous System Depressants Not Applicable
15 Tranquilizing Agents Not Applicable
16 Anesthetics Not Applicable
17 Narcotics Not Applicable
18 Neurotransmitter Agents Not Applicable
19 Anesthetics, General Not Applicable
20 Anesthetics, Intravenous Not Applicable
21 GABA Agents Not Applicable
22 Analgesics, Opioid Not Applicable
23 Anti-Anxiety Agents Not Applicable
24 Neuromuscular Agents Not Applicable
25 Peripheral Nervous System Agents Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Hemodynamics and Vital Organ Function in Intracerebral Hemorrhage Recruiting NCT03129009 Not Applicable Total intravenous anesthesia group;Balanced anesthesia group

Search NIH Clinical Center for Obstructive Nephropathy

Genetic Tests for Obstructive Nephropathy

Anatomical Context for Obstructive Nephropathy

MalaCards organs/tissues related to Obstructive Nephropathy:

41
Kidney, Liver, Lung, Heart, Brain, Testes, Bone

Publications for Obstructive Nephropathy

Articles related to Obstructive Nephropathy:

(show top 50) (show all 1272)
# Title Authors Year
1
Cryptotanshinone hinders renal fibrosis and epithelial transdifferentiation in obstructive nephropathy by inhibiting TGF-I^1/Smad3/integrin I^1 signal. ( 29928474 )
2018
2
Con: Tolvaptan for autosomal dominant polycystic kidney disease-do we know all the answers? ( 30312449 )
2018
3
Ureteral obstructive nephropathy due to compression by intrinsic endometriosis of the ovary. ( 30152447 )
2018
4
Glycyrrhizin alleviates Con A-induced hepatitis by differentially regulating the production of IL-17 and IL-25. ( 30553196 )
2018
5
CD8+ T cell/IL-33/ILC2 axis exacerbates the liver injury in Con A-induced hepatitis in T cell-transferred Rag2-deficient mice. ( 30430216 )
2018
6
Potential Novel Biomarkers of Obstructive Nephropathy in Children with Hydronephrosis. ( 30327688 )
2018
7
Acute obstructive nephropathy in a solitary kidney secondary to massive seminal vesicle cyst. ( 26471897 )
2018
8
Identification of key microRNAs, transcription factors and genes associated with congenital obstructive nephropathy in a mouse model of megabladder. ( 29410288 )
2018
9
Uromodulin deficiency alters tubular injury and interstitial inflammation but not fibrosis in experimental obstructive nephropathy. ( 29595914 )
2018
10
Ginsenoside-Rg1 Protects against Renal Fibrosis by Regulating the Klotho/TGF-β1/Smad Signaling Pathway in Rats with Obstructive Nephropathy. ( 29607931 )
2018
11
Legumain, an asparaginyl endopeptidase, mediates the effect of M2 macrophages on attenuating renal interstitial fibrosis in obstructive nephropathy. ( 29656902 )
2018
12
S100A8/A9 promotes parenchymal damage and renal fibrosis in obstructive nephropathy. ( 29746703 )
2018
13
Hypochlorite modified albumins promote cell death in the tubule interstitium in rats via mitochondrial damage in obstructive nephropathy and the protective effects of antioxidant peptides. ( 29781318 )
2018
14
Candidate gene and mechanism investigations in congenital obstructive nephropathy based on bioinformatics analysis. ( 30015886 )
2018
15
Application of normalized values of kidney clearance function in the diagnosis of bilateral obstructive nephropathy - a preliminary report. ( 30070348 )
2018
16
Lack of microRNA-155 ameliorates renal fibrosis by targeting PDE3A/TGF-β1/Smad signaling in mice with obstructive nephropathy. ( 30080287 )
2018
17
The TGFβ-ERK pathway contributes to Notch3 upregulation in the renal tubular epithelial cells of patients with obstructive nephropathy. ( 30081092 )
2018
18
Renal expression and urinary excretion of Na+/dicarboxylate cotransporter 1 (NaDC1) in obstructive nephropathy: a candidate biomarker for this pathology. ( 30140954 )
2018
19
Tamoxifen ameliorates obstructive nephropathy through Src and the PI3K/Akt/mTOR pathway. ( 30304547 )
2018
20
Biomarkers of obstructive nephropathy using a metabolomics approach in rat. ( 30339777 )
2018
21
Obstructive nephropathy: simple yet complicated! ( 30386975 )
2018
22
Protease-activated receptor-1 contributes to renal injury and interstitial fibrosis during chronic obstructive nephropathy. ( 30485646 )
2018
23
Pronóstico de pacientes con lupus eritematoso generalizado en una unidad de cuidados intensivos. ( 30250333 )
2018
24
Shall We Focus on the Eosinophil to Guide Treatment with Systemic Corticosteroids during Acute Exacerbations of Chronic Obstructive Pulmonary Disease (COPD)? CON. ( 29890705 )
2018
25
CON: Factor Concentrates Should Not Have an Expanded Role in the Routine Management of the Bleeding Cardiac Surgical Patient. ( 28918979 )
2018
26
Con: Factor Concentrate Usage in Cardiac Surgery-A Paucity of Data Limits Their Universal Adoption. ( 28943187 )
2018
27
Con: Liver transplantation for expanded criteria malignant diseases. ( 29125687 )
2018
28
Con: The role of diet for people with advanced Stage 5 CKD. ( 29165595 )
2018
29
Qualitative analysis of the capacity to consent to treatment in patients with a chronic neurodegenerative disease: Alzheimer's disease / Analisi qualitativa sulla capacità a prestare consenso al trattamento in pazienti con malattie cronico degenerative neuropsicoorganiche: Demenza di Alzheimer. ( 29183264 )
2018
30
Adrenal Vein Sampling Is the Preferred Method to Select Patients With Primary Aldosteronism for Adrenalectomy: Con Side of the Argument. ( 29229748 )
2018
31
Con: Routine Use of Embolic Filters in Transcatheter Aortic Valve Replacement Is not Indicated. ( 29277299 )
2018
32
Correction to: Valve-sparing aortic root surgery. CON: remodeling. ( 29313246 )
2018
33
Con: Activated Clotting Time Should Not Be Monitored During Heparinization for Vascular Surgery. ( 29336967 )
2018
34
Childhood Asthma: Is It All About Bacteria and Not About Viruses? A Pro/Con Debate. ( 29339131 )
2018
35
Maintaining Opioid Prescription for Chronic Back Pain: Pro Versus Con. ( 29413121 )
2018
36
Augmentation Therapy Nowadays: Con. ( 29422342 )
2018
37
HOMBRE: A randomized controlled trial to compare two approaches to weight loss for overweight and obese Latino men (Hombres con Opciones para Mejorar el Bienestar y bajar el Riesgo de Enfermedades crónicas; men with choices to improve well-being and decrease chronic disease risk). ( 29505867 )
2018
38
Lower ammoniation activation energy of CoN nanosheets by Mn doping with superior energy storage performance for secondary ion batteries. ( 29527601 )
2018
39
Is Kt/V useful in elderly dialysis patients? Pro and Con arguments. ( 29566211 )
2018
40
Reversible Concanavalin A (Con A) ligands immobilization on metal chelated macroporous cellulose monolith and its selective adsorption for glycoproteins. ( 29580801 )
2018
41
Molecular Med TRI-CON, 11-16 February 2018, San Francisco, USA. ( 29619772 )
2018
42
CMS Consideration of Rebate Overhaul Elicits Strong Opinions Both Pro and Con. ( 29622937 )
2018
43
Should Hypertension Be Treated in Late Life to Preserve Cognitive Function? Con Side of the Argument. ( 29643178 )
2018
44
My Patient the Ex-Con-An Evolution of Perspective. ( 29669153 )
2018
45
Con: Mechanical Ventilation During Cardiopulmonary Bypass Does Not Improve Outcomes After Cardiac Surgery. ( 29680491 )
2018
46
Con-debate: short circulatory arrest times in arch reconstructive surgery: is simple retrograde cerebral perfusion or hypothermic circulatory arrest as good or better than complex antegrade cerebral perfusion for open distal involvement or hemi-arch? ( 29682456 )
2018
47
Con: "Debate: does every ascending aorta repair require at least an open distal anastomosis at the innominate? Or not?" ( 29682459 )
2018
48
Multiple approaches to associations of physical activity and adherence to the Mediterranean diet with all-cause mortality in older adults: the PREvención con DIeta MEDiterránea study. ( 29696401 )
2018
49
When Predators Avoid Predation by Their Con- and Heterospecific Competitors: Non-consumptive Effects Mediate Foraging Behavior and Prey Handling Time of Predators. ( 29726947 )
2018
50
Femoro-jugular cannulation in veno-venous extracorporeal membrane oxygenation PRO/CON. ( 29732178 )
2018

Variations for Obstructive Nephropathy

Expression for Obstructive Nephropathy

Search GEO for disease gene expression data for Obstructive Nephropathy.

Pathways for Obstructive Nephropathy

Pathways related to Obstructive Nephropathy according to GeneCards Suite gene sharing:

(show all 47)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.3 AGT AGTR2 EGF GFER HGF PDGFD
2
Show member pathways
13.22 EGF GFER HGF PDGFD SMAD3 TGFB1
3
Show member pathways
12.99 EGF GFER HGF PDGFD TGFB1
4
Show member pathways
12.8 EGF PDGFD SMAD2 SMAD3 TGFB1
5 12.76 EGF HGF SMAD2 SMAD3 TGFB1
6
Show member pathways
12.68 EGF HGF SMAD2 SMAD3 TGFB1
7
Show member pathways
12.61 EGF GFER HGF PDGFD TGFB1
8
Show member pathways
12.49 ACE AGT AGTR2 EGF GFER HGF
9
Show member pathways
12.47 EGF SMAD2 SMAD3 TGFB1
10
Show member pathways
12.41 PDGFD SMAD2 SMAD3 TGFB1
11
Show member pathways
12.31 EGF GFER HGF PDGFD TGFB1
12
Show member pathways
12.21 SKIL SMAD2 SMAD3 TGFB1
13
Show member pathways
12.2 GFER HGF PDGFD TGFB1
14 12.16 SKIL SMAD2 SMAD3 TGFB1
15 12.08 EGF SMAD2 SMAD3 TGFB1
16 12.02 SKIL SMAD2 SMAD3
17 11.99 AGT SMAD3 TGFB1
18
Show member pathways
11.99 EGF SMAD2 SMAD3 TGFB1
19
Show member pathways
11.98 SMAD2 SMAD3 TGFB1
20 11.96 SKIL SMAD2 SMAD3 TGFB1
21 11.96 ALB EGF HGF TGFB1
22 11.95 SKIL SMAD2 SMAD3 TGFB1
23 11.85 SMAD2 SMAD3 TGFB1
24 11.83 SMAD2 SMAD3 TGFB1
25
Show member pathways
11.81 SMAD2 SMAD3 TGFB1
26 11.79 HGF REN TGFB1
27 11.76 SMAD2 SMAD3 TGFB1
28
Show member pathways
11.71 SMAD2 SMAD3 TGFB1
29 11.7 SKIL SMAD2 SMAD3
30
Show member pathways
11.65 SMAD2 SMAD3 TGFB1
31 11.62 EGF SMAD3 TGFB1
32 11.62 SKIL SMAD2 SMAD3 TGFB1
33 11.61 ACE AGT REN
34 11.6 SKIL SMAD2 SMAD3 TGFB1
35 11.6 EGF GFER HGF PDGFD TGFB1
36
Show member pathways
11.56 ACE AGT AGTR2 REN TGFB1
37 11.53 EGF HGF SKIL TGFB1
38
Show member pathways
11.49 EGF SMAD2 SMAD3 TGFB1
39 11.44 EGF HGF TGFB1
40 11.41 SKIL SMAD2 SMAD3 TGFB1
41 11.32 EGF SKIL SMAD2 SMAD3 TGFB1
42
Show member pathways
11.24 EGF GFER HGF PDGFD SKIL SMAD2
43 11.1 HGF SMAD2 SMAD3 TGFB1
44 10.97 SMAD2 SMAD3
45 10.95 EGF GFER HGF PDGFD TGFB1
46 10.92 HGF TGFB1
47 10.91 SMAD2 SMAD3 TGFB1

GO Terms for Obstructive Nephropathy

Cellular components related to Obstructive Nephropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.85 ACE AGT ALB CLU EGF HGF
2 protein-containing complex GO:0032991 9.8 ALB CLU SKIL SMAD2 SMAD3
3 blood microparticle GO:0072562 9.62 AGT ALB CLU TGFB1
4 extracellular region GO:0005576 9.4 ACE AGT AGTR2 ALB CLU EGF
5 SMAD protein complex GO:0071141 9.37 SMAD2 SMAD3
6 platelet alpha granule lumen GO:0031093 9.35 ALB CLU EGF HGF TGFB1
7 heteromeric SMAD protein complex GO:0071144 9.26 SMAD2 SMAD3

Biological processes related to Obstructive Nephropathy according to GeneCards Suite gene sharing:

(show top 50) (show all 66)
# Name GO ID Score Top Affiliating Genes
1 cell cycle arrest GO:0007050 9.91 SKIL SMAD3 TGFB1
2 kidney development GO:0001822 9.89 ACE AGT REN
3 negative regulation of cell growth GO:0030308 9.89 AGT AGTR2 SMAD3 TGFB1
4 wound healing GO:0042060 9.88 SMAD2 SMAD3 TGFB1
5 positive regulation of cell migration GO:0030335 9.88 EGF HGF PDGFD SMAD3 TGFB1
6 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.85 AGT HGF PDGFD
7 positive regulation of MAP kinase activity GO:0043406 9.85 EGF PDGFD TGFB1
8 cellular response to transforming growth factor beta stimulus GO:0071560 9.85 PDGFD SMAD3 TGFB1
9 SMAD protein signal transduction GO:0060395 9.84 SMAD2 SMAD3 TGFB1
10 transforming growth factor beta receptor signaling pathway GO:0007179 9.83 SKIL SMAD2 SMAD3 TGFB1
11 positive regulation of fibroblast proliferation GO:0048146 9.82 AGT PDGFD TGFB1
12 positive regulation of epithelial to mesenchymal transition GO:0010718 9.81 SMAD2 SMAD3 TGFB1
13 ureteric bud development GO:0001657 9.8 SMAD2 SMAD3 TGFB1
14 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.8 AGT EGF HGF TGFB1
15 positive regulation of protein tyrosine kinase activity GO:0061098 9.79 ACE AGT EGF
16 blood vessel remodeling GO:0001974 9.77 ACE AGT AGTR2
17 endoderm development GO:0007492 9.76 SMAD2 SMAD3 TGFB1
18 adrenal gland development GO:0030325 9.74 SMAD2 SMAD3
19 positive regulation of blood pressure GO:0045777 9.74 ACE AGT
20 embryonic pattern specification GO:0009880 9.73 SMAD2 SMAD3
21 signal transduction involved in regulation of gene expression GO:0023019 9.73 SMAD2 SMAD3
22 vasodilation GO:0042311 9.73 AGT AGTR2
23 negative regulation of release of cytochrome c from mitochondria GO:0090201 9.73 CLU HGF
24 nitric oxide mediated signal transduction GO:0007263 9.73 AGT AGTR2
25 negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 9.73 SKIL SMAD2 SMAD3 TGFB1
26 regulation of peptidyl-tyrosine phosphorylation GO:0050730 9.72 EGF PDGFD
27 activin receptor signaling pathway GO:0032924 9.72 SMAD2 SMAD3
28 cellular sodium ion homeostasis GO:0006883 9.72 AGT AGTR2
29 positive regulation of cellular protein metabolic process GO:0032270 9.72 AGT TGFB1
30 cell growth involved in cardiac muscle cell development GO:0061049 9.71 AGT AGTR2
31 positive regulation of superoxide anion generation GO:0032930 9.71 AGT TGFB1
32 positive regulation of ubiquitin-dependent protein catabolic process GO:2000060 9.71 CLU EGF
33 amyloid-beta metabolic process GO:0050435 9.71 ACE REN
34 positive regulation of renal sodium excretion GO:0035815 9.71 AGT AGTR2
35 regulation of blood vessel diameter GO:0097746 9.7 ACE AGTR2
36 angiotensin maturation GO:0002003 9.7 ACE REN
37 nodal signaling pathway GO:0038092 9.7 SMAD2 SMAD3
38 primary miRNA processing GO:0031053 9.69 SMAD2 SMAD3
39 response to cholesterol GO:0070723 9.69 SMAD2 TGFB1
40 regulation of transforming growth factor beta receptor signaling pathway GO:0017015 9.69 SMAD2 SMAD3 TGFB1
41 embryonic foregut morphogenesis GO:0048617 9.68 SMAD2 SMAD3
42 pericardium development GO:0060039 9.68 SMAD2 SMAD3
43 regulation of protein import into nucleus GO:0042306 9.68 AGTR2 TGFB1
44 regulation of blood pressure GO:0008217 9.67 ACE AGT AGTR2 REN
45 common-partner SMAD protein phosphorylation GO:0007182 9.66 SMAD2 TGFB1
46 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 9.66 ACE AGT
47 positive regulation of extracellular matrix assembly GO:1901203 9.64 SMAD3 TGFB1
48 negative regulation of neurotrophin TRK receptor signaling pathway GO:0051387 9.63 AGT AGTR2
49 regulation of striated muscle tissue development GO:0016202 9.63 SMAD3 TGFB1
50 positive regulation of branching involved in ureteric bud morphogenesis GO:0090190 9.63 AGT AGTR2 TGFB1

Molecular functions related to Obstructive Nephropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 tau protein binding GO:0048156 9.46 CLU SMAD2
2 enhancer binding GO:0035326 9.43 SMAD2 SMAD3
3 SMAD binding GO:0046332 9.43 SKIL SMAD2 SMAD3
4 co-SMAD binding GO:0070410 9.4 SMAD2 SMAD3
5 type I transforming growth factor beta receptor binding GO:0034713 9.37 SMAD2 TGFB1
6 primary miRNA binding GO:0070878 9.32 SMAD2 SMAD3
7 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity GO:0030618 9.16 SMAD2 SMAD3
8 transforming growth factor beta receptor binding GO:0005160 9.13 SMAD2 SMAD3 TGFB1
9 growth factor activity GO:0008083 9.1 AGT EGF GFER HGF PDGFD TGFB1

Sources for Obstructive Nephropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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