Occipital Lobe Neoplasm disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Occipital Lobe Neoplasm

MalaCards integrated aliases for Occipital Lobe Neoplasm:

Name: Occipital Lobe Neoplasm ¹² ¹⁵

Neoplasm of Occipital Lobe ¹² ⁷⁰

Malignant Neoplasm of Occipital Lobe ¹²

Tumor of Occipital Lobe ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Neuronal diseases

See all MalaCards categories (disease lists)

ICD10: ³²

Neoplasms

Malignant neoplasms of eye, brain and other parts of central nervous system

Malignant neoplasm of brain

Malignant neoplasm: Occipital lobe

External Ids:

Disease Ontology ¹² DOID:910

ICD9CM ³⁴ 191.4

NCIt ⁵⁰ C5574

SNOMED-CT ⁶⁷ 126957005 93928006

ICD10 ³² C71.4

UMLS ⁷⁰ C0153638 C1263889

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Summaries for Occipital Lobe Neoplasm

MalaCards based summary : Occipital Lobe Neoplasm, also known as neoplasm of occipital lobe, is related to adenosquamous lung carcinoma and pulmonary large cell neuroendocrine carcinoma. An important gene associated with Occipital Lobe Neoplasm is TPR (Translocated Promoter Region, Nuclear Basket Protein), and among its related pathways/superpathways are Pathways in cancer and Glioma. Affiliated tissues include occipital lobe, brain and eye, and related phenotype is Decreased viability after Chlamydia trachomatis serovar L2 infection and TNF-alpha/CHX stimulation.

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Related Diseases for Occipital Lobe Neoplasm

Diseases related to Occipital Lobe Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 21)

#	Related Disease	Score	Top Affiliating Genes
1	adenosquamous lung carcinoma	10.0	KIF5B ALK
2	pulmonary large cell neuroendocrine carcinoma	10.0	KIF5B ALK
3	large cell neuroendocrine carcinoma	10.0	KIF5B ALK
4	signet ring lung adenocarcinoma	10.0	EML4 ALK
5	lung sarcomatoid carcinoma	9.9	EML4 ALK
6	malignant giant cell tumor of the tendon sheath	9.9	ROS1 ALK
7	lung carcinoma in situ	9.9	EML4 ALK
8	pulmonary adenocarcinoma in situ	9.9	EML4 ALK
9	familial renal papillary carcinoma	9.9	TPR MET
10	perinephritis	9.9	ROS1 ALK
11	spitzoid melanoma	9.8	ROS1 ALK
12	large cell medulloblastoma	9.7	MET ALK
13	congenital fibrosarcoma	9.7	TFG ROS1 ALK
14	mesenchymal cell neoplasm	9.6	ROS1 EML4 ALK
15	peritoneal mesothelioma	9.6	MET ALK
16	lung non-squamous non-small cell carcinoma	9.4	ROS1 KIF5B EML4 ALK
17	thyroid gland cancer	9.4	MET KIF5B ALK
18	pediatric fibrosarcoma	9.4	TFG ROS1 EML4 ALK
19	differentiated thyroid carcinoma	9.4	TPR TFG MET ALK
20	inflammatory myofibroblastic tumor	9.4	TFG ROS1 EML4 ALK
21	skin melanoma	9.1	ROS1 MET ALK

Graphical network of the top 20 diseases related to Occipital Lobe Neoplasm:

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Symptoms & Phenotypes for Occipital Lobe Neoplasm

GenomeRNAi Phenotypes related to Occipital Lobe Neoplasm according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased viability after Chlamydia trachomatis serovar L2 infection and TNF-alpha/CHX stimulation	GR00206-A	8.62	KIF5B MET

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Drugs & Therapeutics for Occipital Lobe Neoplasm

Search Clinical Trials , NIH Clinical Center for Occipital Lobe Neoplasm

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Genetic Tests for Occipital Lobe Neoplasm

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Anatomical Context for Occipital Lobe Neoplasm

MalaCards organs/tissues related to Occipital Lobe Neoplasm:

⁴⁰

Occipital Lobe, Brain, Eye

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Publications for Occipital Lobe Neoplasm

Articles related to Occipital Lobe Neoplasm:

#	Title	Authors	PMID	Year
1	Ocular motility testing in the evaluation of visual hallucinations. ⁶¹	Lessell S...Currie JN	6859186	1983

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Genes for Occipital Lobe Neoplasm

Genes related to Occipital Lobe Neoplasm (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	TPR	Translocated Promoter Region, Nuclear Basket Protein	Protein Coding	5.65	DISEASES inferred ¹⁵
2	SPTBN1	Spectrin Beta, Non-Erythrocytic 1	Protein Coding	5.6	DISEASES inferred ¹⁵
3	KLC1	Kinesin Light Chain 1	Protein Coding	5.5	DISEASES inferred ¹⁵
4	KIF5B	Kinesin Family Member 5B	Protein Coding	5.07	DISEASES inferred ¹⁵
5	TFG	Trafficking From ER To Golgi Regulator	Protein Coding	4.94	DISEASES inferred ¹⁵
6	EML4	EMAP Like 4	Protein Coding	4.35	DISEASES inferred ¹⁵
7	ROS1	ROS Proto-Oncogene 1, Receptor Tyrosine Kinase	Protein Coding	4.34	DISEASES inferred ¹⁵
8	MET	MET Proto-Oncogene, Receptor Tyrosine Kinase	Protein Coding	3.78	DISEASES inferred ¹⁵
9	ALK	ALK Receptor Tyrosine Kinase	Protein Coding	3.58	DISEASES inferred ¹⁵

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Variations for Occipital Lobe Neoplasm

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Expression for Occipital Lobe Neoplasm

Search GEO for disease gene expression data for Occipital Lobe Neoplasm.

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Pathways for Occipital Lobe Neoplasm

Pathways related to Occipital Lobe Neoplasm according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Pathways in cancer ³⁶	12.08	TPR TFG MET EML4 ALK
2	Glioma ³⁶ Show member pathways Endocrine resistance ³⁶ Melanoma ³⁶ Non-small cell lung cancer ³⁶ Signaling Pathways in Glioblastoma ¹	12.06	MET KIF5B EML4 ALK
3	Tyrosine Kinases / Adaptors ⁴	11.67	ROS1 MET ALK
4	Crizotinib Pathway, Pharmacokinetics/Pharmacodynamics ⁶⁰	10.5	ROS1 MET EML4 ALK
5	RHO GTPases activate KTN1 ⁶⁵	10.3	KLC1 KIF5B

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GO Terms for Occipital Lobe Neoplasm

Cellular components related to Occipital Lobe Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	microtubule	GO:0005874	9.43	KLC1 KIF5B EML4
2	cytoskeleton	GO:0005856	9.35	TPR SPTBN1 KLC1 KIF5B EML4
3	kinesin complex	GO:0005871	9.16	KLC1 KIF5B
4	receptor complex	GO:0043235	8.8	ROS1 MET ALK

Biological processes related to Occipital Lobe Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	peptidyl-tyrosine phosphorylation	GO:0018108	9.43	ROS1 MET ALK
2	hippocampus development	GO:0021766	9.4	KIF5B ALK
3	positive regulation of protein localization to plasma membrane	GO:1903078	9.37	SPTBN1 KIF5B
4	transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	9.33	ROS1 MET ALK
5	positive regulation of intracellular protein transport	GO:0090316	9.32	TPR KIF5B
6	positive regulation of kinase activity	GO:0033674	9.13	ROS1 MET ALK
7	stress granule disassembly	GO:0035617	8.62	KLC1 KIF5B

Molecular functions related to Occipital Lobe Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein tyrosine kinase activity	GO:0004713	9.13	ROS1 MET ALK
2	transmembrane receptor protein tyrosine kinase activity	GO:0004714	8.8	ROS1 MET ALK

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Sources for Occipital Lobe Neoplasm

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