MCID: OCC005
MIFTS: 30

Occlusion Precerebral Artery

Categories: Cardiovascular diseases, Neuronal diseases

Aliases & Classifications for Occlusion Precerebral Artery

MalaCards integrated aliases for Occlusion Precerebral Artery:

Name: Occlusion Precerebral Artery 12 15 17
Occlusion and Stenosis of Multiple and Bilateral Precerebral Arteries 12 32
Occlusion and Stenosis of Precerebral Artery 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5976
ICD9CM 34 433.9
ICD10 32 I65.3 I65.9
UMLS 70 C0155727

Summaries for Occlusion Precerebral Artery

MalaCards based summary : Occlusion Precerebral Artery, also known as occlusion and stenosis of multiple and bilateral precerebral arteries, is related to basal ganglia cerebrovascular disease and ligneous conjunctivitis. An important gene associated with Occlusion Precerebral Artery is PLG (Plasminogen), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Measles. Affiliated tissues include brain, spinal cord and heart, and related phenotypes are growth/size/body region and behavior/neurological

Related Diseases for Occlusion Precerebral Artery

Diseases related to Occlusion Precerebral Artery via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 184)
# Related Disease Score Top Affiliating Genes
1 basal ganglia cerebrovascular disease 10.4 PLG PLAT
2 ligneous conjunctivitis 10.4 PLG PLAT
3 basilar artery insufficiency 10.4 PLG PLAT
4 medulloadrenal hyperfunction 10.4 PLG F3
5 femoral neuropathy 10.4 PLAT F3
6 acquired hemophilia 10.4 F3 F11
7 acquired hemophilia a 10.4 F3 F11
8 cerebellar liponeurocytoma 10.4 RBFOX3 MAP2
9 brown-sequard syndrome 10.4 PLG AIF1
10 brain stem infarction 10.4 PLG PLAT
11 acute anterolateral myocardial infarction 10.4 PLG ITGA2B
12 vertebral artery occlusion 10.4 PLG PLAT
13 lateral myocardial infarction 10.3 PLG ITGA2B
14 anterior cerebral artery infarction 10.3 RBFOX3 PLG PLAT
15 neonatal hypoxic and ischemic brain injury 10.3 MBP BDNF
16 cerebral falx meningioma 10.3 PLG PLAT F3
17 acute pulmonary heart disease 10.3 PLG PLAT F3
18 intracranial sinus thrombosis 10.3 PLG F3
19 acute cor pulmonale 10.3 PLG PLAT F3
20 posterior cerebral artery infarction 10.3 PLG PLAT F3
21 inferior myocardial infarction 10.3 PLG PLAT
22 hemopericardium 10.3 PLG F3
23 cardiac tamponade 10.3 PLG PLAT F3
24 post-thrombotic syndrome 10.3 PLG PLAT F3
25 thrombophlebitis 10.3 PLG PLAT F3
26 plasminogen deficiency, type i 10.3 PLG PLAT
27 conversion disorder 10.3 PLG PLAT BDNF
28 basilar artery occlusion 10.3 PLG PLAT ITGA2B
29 autoimmune optic neuritis 10.3 MBP AIF1
30 hepatic veno-occlusive disease 10.3 PLG PLAT F3
31 chiari malformation 10.3 MBP MAP2 GFAP
32 endocardium disease 10.3 PLG IL1B F3
33 platelet aggregation, spontaneous 10.3 SELP PLAT
34 autoimmune disease of cardiovascular system 10.3 PLG IL1B F3
35 middle ear adenocarcinoma 10.3 GFAP AIF1
36 alveolar periostitis 10.3 PLG KNG1
37 dysembryoplastic neuroepithelial tumor 10.3 RBFOX3 MAP2 GFAP
38 cerebral hypoxia 10.3 FOS CASP3
39 central neurocytoma 10.3 RBFOX3 MAP2 GFAP
40 leech infestation 10.2 PLG F3
41 disseminated intravascular coagulation 10.2 PLG PLAT F3
42 moyamoya disease 1 10.2 PLG PLAT F3
43 actinomycosis 10.2 IL1B CASP3 AIF1
44 spinal cord oligodendroglioma 10.2 RBFOX3 GFAP
45 diabetic encephalopathy 10.2 IL1B CASP3 BDNF
46 spinal cord disease 10.2 MBP IL1B GFAP
47 retinal vascular disease 10.2 PLG IL1B CASP3
48 neuromyelitis optica 10.2 MBP IL1B GFAP
49 transient cerebral ischemia 10.2 MAP2 IL1B CASP3
50 acquired thrombocytopenia 10.2 ITGA2B F11

Graphical network of the top 20 diseases related to Occlusion Precerebral Artery:



Diseases related to Occlusion Precerebral Artery

Symptoms & Phenotypes for Occlusion Precerebral Artery

MGI Mouse Phenotypes related to Occlusion Precerebral Artery:

46 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.39 ADCYAP1 BDNF CASP3 CYCS F11 F3
2 behavior/neurological MP:0005386 10.36 ADCYAP1 BDNF CASP3 CYCS F11 F3
3 homeostasis/metabolism MP:0005376 10.33 ADCYAP1 AIF1 BDNF CASP3 EPO F11
4 cellular MP:0005384 10.32 ADCYAP1 BDNF CASP3 CYCS EPO F11
5 cardiovascular system MP:0005385 10.31 AIF1 CASP3 CYCS EPO F11 F3
6 hematopoietic system MP:0005397 10.28 ADCYAP1 AIF1 CASP3 CYCS EPO F11
7 immune system MP:0005387 10.24 ADCYAP1 AIF1 CASP3 CYCS EPO F11
8 mortality/aging MP:0010768 10.19 ADCYAP1 BDNF CASP3 CYCS EPO F11
9 nervous system MP:0003631 10.09 ADCYAP1 AIF1 BDNF CASP3 CYCS F11
10 integument MP:0010771 10.02 BDNF CASP3 EPO F3 FOS IL1B
11 respiratory system MP:0005388 9.56 BDNF CASP3 EPO F11 F3 PLAT
12 vision/eye MP:0005391 9.36 ADCYAP1 AIF1 BDNF CASP3 F3 FOS

Drugs & Therapeutics for Occlusion Precerebral Artery

Search Clinical Trials , NIH Clinical Center for Occlusion Precerebral Artery

Genetic Tests for Occlusion Precerebral Artery

Anatomical Context for Occlusion Precerebral Artery

MalaCards organs/tissues related to Occlusion Precerebral Artery:

40
Brain, Spinal Cord, Heart, Colon, Liver, Myeloid

Publications for Occlusion Precerebral Artery

Variations for Occlusion Precerebral Artery

Expression for Occlusion Precerebral Artery

Search GEO for disease gene expression data for Occlusion Precerebral Artery.

Pathways for Occlusion Precerebral Artery

Pathways related to Occlusion Precerebral Artery according to GeneCards Suite gene sharing:

(show all 27)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.19 SELP PLG PLAT KNG1 ITGA2B F3
2
Show member pathways
12.71 PLG IL1B FOS CYCS CASP3
3 12.66 KNG1 ITGA2B FOS EPO CYCS CASP3
4 12.46 RBFOX3 MBP MAP2 GRIN2B GFAP
5 12.21 GRIN2B FOS BDNF ADCYAP1
6
Show member pathways
12.16 MBP MAP2 FOS CASP3
7
Show member pathways
12.14 IL1B FOS CYCS CASP3
8 11.98 IL1B GRIN2B CYCS CASP3
9 11.98 MAP2 IL1B CASP3 BDNF ADCYAP1
10 11.95 GRIN2B FOS CASP3 BDNF
11 11.92 PLAT ITGA2B IL1B FOS
12
Show member pathways
11.92 PLG PLAT KNG1 F3 F11
13 11.82 PLG PLAT KNG1 F3 F11
14 11.81 IL1B F3 CASP3
15 11.8 ITGA2B IL1B EPO
16 11.75 ITGA2B CYCS CASP3
17 11.67 MAP2 GFAP BDNF
18 11.64 IL1B FOS CASP3
19
Show member pathways
11.52 PLG CYCS CASP3 BDNF
20 11.48 IL1B CYCS CASP3
21 11.3 SELP MBP IL1B GFAP FOS CASP3
22 11.14 ITGA2B IL1B FOS EPO
23 11.01 GRIN2B CYCS CASP3
24 10.94 SELP PLG PLAT KNG1
25 10.92 ITGA2B IL1B GFAP FOS BDNF
26 10.77 CASP3 BDNF
27 10.72 PLG PLAT

GO Terms for Occlusion Precerebral Artery

Cellular components related to Occlusion Precerebral Artery according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.81 PLG PLAT KNG1 IL1B F3 F11
2 extracellular space GO:0005615 9.65 SELP PLG PLAT KNG1 IL1B F3
3 cell surface GO:0009986 9.17 PLG PLAT MBP ITGA2B GRIN2B F3

Biological processes related to Occlusion Precerebral Artery according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.8 SELP KNG1 IL1B FOS AIF1
2 platelet degranulation GO:0002576 9.62 SELP PLG KNG1 ITGA2B
3 positive regulation of interleukin-6 production GO:0032755 9.56 MBP IL1B AIF1 ADCYAP1
4 blood coagulation GO:0007596 9.55 PLG PLAT KNG1 F3 F11
5 positive regulation of leukocyte migration GO:0002687 9.46 SELP ITGA2B
6 plasminogen activation GO:0031639 9.43 PLAT F11
7 positive regulation of fibrinolysis GO:0051919 9.37 PLG F11
8 response to lipopolysaccharide GO:0032496 9.35 SELP IL1B FOS EPO CASP3
9 hemostasis GO:0007599 8.92 PLG KNG1 F3 F11

Molecular functions related to Occlusion Precerebral Artery according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.13 SELP PLG PLAT MBP MAP2 KNG1
2 signaling receptor binding GO:0005102 9.35 PLG PLAT KNG1 BDNF ADCYAP1
3 serine-type endopeptidase activity GO:0004252 8.92 PLG PLAT F3 F11

Sources for Occlusion Precerebral Artery

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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