MCID: OCC005
MIFTS: 30

Occlusion Precerebral Artery

Categories: Cardiovascular diseases, Neuronal diseases

Aliases & Classifications for Occlusion Precerebral Artery

MalaCards integrated aliases for Occlusion Precerebral Artery:

Name: Occlusion Precerebral Artery 12 15
Occlusion and Stenosis of Multiple and Bilateral Precerebral Arteries 12
Occlusion and Stenosis of Precerebral Artery 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5976
ICD10 33 I65.9 I65.3
ICD9CM 35 433 433.9
UMLS 73 C0155727

Summaries for Occlusion Precerebral Artery

MalaCards based summary : Occlusion Precerebral Artery, also known as occlusion and stenosis of multiple and bilateral precerebral arteries, is related to basilar artery occlusion and carotid artery occlusion. An important gene associated with Occlusion Precerebral Artery is BCO1 (Beta-Carotene Oxygenase 1), and among its related pathways/superpathways are G-protein signaling Ras family GTPases in kinase cascades (scheme) and Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. Affiliated tissues include brain and heart, and related phenotypes are Decreased caspase 3/7 activity and growth/size/body region

Related Diseases for Occlusion Precerebral Artery

Diseases related to Occlusion Precerebral Artery via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 32)
# Related Disease Score Top Affiliating Genes
1 basilar artery occlusion 31.1 PLAT PLG
2 carotid artery occlusion 30.2 BCO1 CA1 CA4 HSPA1A MAP2 MBP
3 vertebral artery occlusion 10.5
4 ligneous conjunctivitis 10.2 PLAT PLG
5 intracranial embolism 10.2 PLAT PLG
6 inferior myocardial infarction 10.2 PLAT PLG
7 central retinal artery occlusion 10.2 PLAT PLG
8 acute cor pulmonale 10.2 PLAT PLG
9 acute pulmonary heart disease 10.2 PLAT PLG
10 anterior spinal artery syndrome 10.2 MBP PLG
11 chiari malformation 10.2 MAP2 MBP
12 intermediate coronary syndrome 10.2 PLAT PLG
13 olivopontocerebellar atrophy 10.2 MAP2 MBP
14 pulmonary artery disease 10.1 PLAT PLG
15 carotid artery dissection 10.1 PLAT PLG
16 osteopetrosis, autosomal recessive 3 10.1 CA1 CA4
17 hepatic veno-occlusive disease 10.1 PLAT PLG
18 traumatic brain injury 10.1 CASP3 MBP
19 brain injury 10.1 CASP3 MBP
20 krabbe disease 10.1 CASP3 MBP
21 optic nerve glioma 10.0 MAP2 MBP
22 vein disease 10.0 PLAT PLG
23 dysembryoplastic neuroepithelial tumor 10.0 GRIN1 MAP2
24 hemimegalencephaly 10.0 GRIN1 MAP2
25 thrombophilia due to activated protein c resistance 10.0 PLAT PLG
26 transient cerebral ischemia 9.9 CASP3 HSPA1A MAP2
27 central nervous system disease 9.9 CASP3 MBP PLAT PLG
28 toxic encephalopathy 9.9 CASP3 GRIN2B MAP2
29 ocular dominance 9.8 GRIN1 GRIN2B
30 ischemia 9.8 CASP3 HSPA1A MAP2 PLAT
31 stroke, ischemic 9.8 CASP3 MAP2 MBP PLAT PLG
32 nervous system disease 9.7 CASP3 GRIN2B MBP PLAT PLG

Graphical network of the top 20 diseases related to Occlusion Precerebral Artery:



Diseases related to Occlusion Precerebral Artery

Symptoms & Phenotypes for Occlusion Precerebral Artery

GenomeRNAi Phenotypes related to Occlusion Precerebral Artery according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased caspase 3/7 activity GR00318-A 8.8 CASP3 GRIN1 GRIN2B

MGI Mouse Phenotypes related to Occlusion Precerebral Artery:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.81 BCO1 CA4 CASP3 GRIN1 GRIN2B MAP2
2 homeostasis/metabolism MP:0005376 9.61 BCO1 CA4 CASP3 GRIN1 GRIN2B KLKB1
3 reproductive system MP:0005389 9.17 CA4 CASP3 GRIN1 MAP2 MBP PLAT

Drugs & Therapeutics for Occlusion Precerebral Artery

Search Clinical Trials , NIH Clinical Center for Occlusion Precerebral Artery

Genetic Tests for Occlusion Precerebral Artery

Anatomical Context for Occlusion Precerebral Artery

MalaCards organs/tissues related to Occlusion Precerebral Artery:

41
Brain, Heart

Publications for Occlusion Precerebral Artery

Variations for Occlusion Precerebral Artery

Expression for Occlusion Precerebral Artery

Search GEO for disease gene expression data for Occlusion Precerebral Artery.

Pathways for Occlusion Precerebral Artery

Pathways related to Occlusion Precerebral Artery according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.98 CASP3 MAP2 MBP
2 11.88 CASP3 GRIN1 MAP2
3
Show member pathways
11.83 KLKB1 PLAT PLG
4 11.79 GRIN1 GRIN2B MAP2 MBP
5 11.74 CASP3 GRIN1 GRIN2B
6 11.69 KLKB1 PLAT PLG
7 11.58 CASP3 GRIN1 MBP
8
Show member pathways
11.49 CASP3 GRIN1 GRIN2B
9 11.16 GRIN1 GRIN2B
10
Show member pathways
11.08 CA1 CA4
11
Show member pathways
10.99 CA1 CA4
12 10.97 GRIN1 GRIN2B
13 10.84 PLAT PLG
14 10.76 GRIN1 GRIN2B
15 10.49 KLKB1 PLAT PLG
16 10.27 PLAT PLG

GO Terms for Occlusion Precerebral Artery

Cellular components related to Occlusion Precerebral Artery according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 synaptic membrane GO:0097060 9.26 GRIN1 GRIN2B
2 postsynaptic density membrane GO:0098839 9.16 GRIN1 GRIN2B
3 cell surface GO:0009986 9.1 CA4 GRIN1 GRIN2B MBP PLAT PLG
4 NMDA selective glutamate receptor complex GO:0017146 8.96 GRIN1 GRIN2B

Biological processes related to Occlusion Precerebral Artery according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 MAPK cascade GO:0000165 9.67 GRIN1 GRIN2B MBP
2 blood coagulation GO:0007596 9.65 KLKB1 PLAT PLG
3 bicarbonate transport GO:0015701 9.52 CA1 CA4
4 cellular response to organic substance GO:0071310 9.51 CASP3 MAP2
5 regulation of axonogenesis GO:0050770 9.46 GRIN1 MAP2
6 ionotropic glutamate receptor signaling pathway GO:0035235 9.43 GRIN1 GRIN2B
7 plasminogen activation GO:0031639 9.4 KLKB1 PLAT
8 positive regulation of cysteine-type endopeptidase activity GO:2001056 9.37 GRIN1 GRIN2B
9 learning or memory GO:0007611 9.33 CASP3 GRIN1 GRIN2B
10 excitatory chemical synaptic transmission GO:0098976 9.32 GRIN1 GRIN2B
11 calcium ion transmembrane import into cytosol GO:0097553 9.26 GRIN1 GRIN2B
12 positive regulation of fibrinolysis GO:0051919 8.96 KLKB1 PLG
13 fibrinolysis GO:0042730 8.8 KLKB1 PLAT PLG

Molecular functions related to Occlusion Precerebral Artery according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 peptidase activity GO:0008233 9.76 CASP3 KLKB1 PLAT PLG
2 signaling receptor binding GO:0005102 9.71 GRIN1 HSPA1A PLAT PLG
3 calmodulin binding GO:0005516 9.65 GRIN1 MAP2 MBP
4 serine-type peptidase activity GO:0008236 9.61 KLKB1 PLAT PLG
5 carbonate dehydratase activity GO:0004089 9.37 CA1 CA4
6 glycine binding GO:0016594 9.32 GRIN1 GRIN2B
7 ionotropic glutamate receptor activity GO:0004970 9.26 GRIN1 GRIN2B
8 glutamate binding GO:0016595 9.16 GRIN1 GRIN2B
9 NMDA glutamate receptor activity GO:0004972 8.96 GRIN1 GRIN2B
10 glutamate-gated calcium ion channel activity GO:0022849 8.62 GRIN1 GRIN2B
11 protein binding GO:0005515 10.24 CA1 CA4 CASP3 GRIN1 GRIN2B HSPA1A

Sources for Occlusion Precerebral Artery

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....