MCID: OCC005
MIFTS: 29

Occlusion Precerebral Artery

Categories: Cardiovascular diseases

Aliases & Classifications for Occlusion Precerebral Artery

MalaCards integrated aliases for Occlusion Precerebral Artery:

Name: Occlusion Precerebral Artery 12 15 17
Occlusion and Stenosis of Multiple and Bilateral Precerebral Arteries 12
Occlusion and Stenosis of Precerebral Artery 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5976
ICD9CM 36 433 433.9
ICD10 34 I65.3 I65.9
UMLS 74 C0155727

Summaries for Occlusion Precerebral Artery

MalaCards based summary : Occlusion Precerebral Artery, also known as occlusion and stenosis of multiple and bilateral precerebral arteries, is related to basilar artery occlusion and carotid artery occlusion. An important gene associated with Occlusion Precerebral Artery is BCO1 (Beta-Carotene Oxygenase 1), and among its related pathways/superpathways are Neuropathic Pain-Signaling in Dorsal Horn Neurons and Neuroscience. Related phenotypes are Decreased caspase 3/7 activity and growth/size/body region

Related Diseases for Occlusion Precerebral Artery

Diseases related to Occlusion Precerebral Artery via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 32)
# Related Disease Score Top Affiliating Genes
1 basilar artery occlusion 31.0 PLAT PLG SLC12A3
2 carotid artery occlusion 30.5 BCO1 CA1 CA4 MAP2 MBP
3 vertebral artery occlusion 10.6
4 ligneous conjunctivitis 10.3 PLAT PLG
5 intracranial embolism 10.3 PLAT PLG
6 inferior myocardial infarction 10.3 PLAT PLG
7 central retinal artery occlusion 10.3 PLAT PLG
8 acute cor pulmonale 10.3 PLAT PLG
9 chiari malformation 10.3 MAP2 MBP
10 acute pulmonary heart disease 10.3 PLAT PLG
11 anterior spinal artery syndrome 10.3 MBP PLG
12 olivopontocerebellar atrophy 10.3 MAP2 MBP
13 intermediate coronary syndrome 10.2 PLAT PLG
14 pulmonary artery disease 10.2 PLAT PLG
15 traumatic brain injury 10.2 CASP3 MBP
16 cerebral hypoxia 10.1 CASP3 FOS
17 carotid artery dissection 10.1 PLAT PLG
18 ischemia 10.0 CASP3 MAP2 PLAT
19 krabbe disease 10.0 CASP3 MBP
20 transient global amnesia 10.0 CA1 FOS
21 osteopetrosis, autosomal recessive 3 10.0 CA1 CA4 SLC12A3
22 dysembryoplastic neuroepithelial tumor 10.0 GRIN1 MAP2
23 hemimegalencephaly 10.0 GRIN1 MAP2
24 renal hypertension 10.0 KLKB1 SLC12A3
25 hepatic veno-occlusive disease 10.0 PLAT PLG
26 central nervous system disease 9.9 CASP3 MBP PLAT PLG
27 toxic encephalopathy 9.9 CASP3 GRIN2B MAP2
28 morphine dependence 9.8 FOS GRIN1
29 status epilepticus 9.8 CASP3 FOS GRIN2B
30 stroke, ischemic 9.8 CASP3 MAP2 MBP PLAT PLG
31 ocular dominance 9.7 GRIN1 GRIN2B
32 nervous system disease 9.6 CASP3 GRIN2B MBP PLAT PLG

Graphical network of the top 20 diseases related to Occlusion Precerebral Artery:



Diseases related to Occlusion Precerebral Artery

Symptoms & Phenotypes for Occlusion Precerebral Artery

GenomeRNAi Phenotypes related to Occlusion Precerebral Artery according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased caspase 3/7 activity GR00318-A 8.8 CASP3 GRIN1 GRIN2B

MGI Mouse Phenotypes related to Occlusion Precerebral Artery:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.1 BCO1 CA4 CASP3 FOS GRIN1 GRIN2B
2 homeostasis/metabolism MP:0005376 10.06 BCO1 CA4 CASP3 FOS GRIN1 GRIN2B
3 cardiovascular system MP:0005385 9.91 CASP3 GRIN1 KLKB1 PLAT PLG SLC12A3
4 mortality/aging MP:0010768 9.91 CA4 CASP3 FOS GRIN1 GRIN2B MAP2
5 hearing/vestibular/ear MP:0005377 9.77 CASP3 FOS GRIN1 MBP PLAT
6 nervous system MP:0003631 9.76 CASP3 FOS GRIN1 GRIN2B MAP2 MBP
7 reproductive system MP:0005389 9.56 CA4 CASP3 FOS GRIN1 MAP2 MBP
8 vision/eye MP:0005391 9.1 CASP3 FOS GRIN1 MBP PLAT PLG

Drugs & Therapeutics for Occlusion Precerebral Artery

Search Clinical Trials , NIH Clinical Center for Occlusion Precerebral Artery

Genetic Tests for Occlusion Precerebral Artery

Anatomical Context for Occlusion Precerebral Artery

Publications for Occlusion Precerebral Artery

Variations for Occlusion Precerebral Artery

Expression for Occlusion Precerebral Artery

Search GEO for disease gene expression data for Occlusion Precerebral Artery.

Pathways for Occlusion Precerebral Artery

Pathways related to Occlusion Precerebral Artery according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.35 FOS GRIN1 GRIN2B SLC12A3
2 12.2 GRIN1 GRIN2B MAP2 MBP
3 12.07 FOS GRIN1 GRIN2B
4 11.92 CASP3 GRIN1 MAP2
5
Show member pathways
11.9 KLKB1 PLAT PLG
6
Show member pathways
11.81 CASP3 FOS MAP2 MBP
7 11.8 KLKB1 PLAT PLG
8
Show member pathways
11.68 FOS GRIN1 GRIN2B
9
Show member pathways
11.64 CASP3 GRIN1 GRIN2B
10 11.42 CASP3 FOS GRIN1 GRIN2B
11
Show member pathways
11.02 CA1 CA4
12 11.02 KLKB1 PLAT PLG
13 11.01 GRIN1 GRIN2B
14 11 CASP3 FOS GRIN1 MBP
15 10.87 PLAT PLG
16 10.82 GRIN1 GRIN2B
17 10.44 PLAT PLG

GO Terms for Occlusion Precerebral Artery

Cellular components related to Occlusion Precerebral Artery according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuron projection GO:0043005 9.46 FOS GRIN1 GRIN2B MAP2
2 synaptic membrane GO:0097060 9.32 GRIN1 GRIN2B
3 postsynaptic density membrane GO:0098839 9.26 GRIN1 GRIN2B
4 cell surface GO:0009986 9.1 CA4 GRIN1 GRIN2B MBP PLAT PLG
5 NMDA selective glutamate receptor complex GO:0017146 8.96 GRIN1 GRIN2B

Biological processes related to Occlusion Precerebral Artery according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 blood coagulation GO:0007596 9.67 KLKB1 PLAT PLG
2 positive regulation of neuron death GO:1901216 9.51 FOS GRIN2B
3 regulation of axonogenesis GO:0050770 9.48 GRIN1 MAP2
4 ionotropic glutamate receptor signaling pathway GO:0035235 9.46 GRIN1 GRIN2B
5 plasminogen activation GO:0031639 9.43 KLKB1 PLAT
6 learning or memory GO:0007611 9.43 CASP3 GRIN1 GRIN2B
7 positive regulation of cysteine-type endopeptidase activity GO:2001056 9.4 GRIN1 GRIN2B
8 excitatory chemical synaptic transmission GO:0098976 9.37 GRIN1 GRIN2B
9 calcium ion transmembrane import into cytosol GO:0097553 9.32 GRIN1 GRIN2B
10 conditioned taste aversion GO:0001661 9.16 FOS GRIN1
11 positive regulation of fibrinolysis GO:0051919 8.96 KLKB1 PLG
12 fibrinolysis GO:0042730 8.8 KLKB1 PLAT PLG

Molecular functions related to Occlusion Precerebral Artery according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidase activity GO:0008233 9.78 CASP3 KLKB1 PLAT PLG
2 calmodulin binding GO:0005516 9.63 GRIN1 MAP2 MBP
3 serine-type peptidase activity GO:0008236 9.58 KLKB1 PLAT PLG
4 carbonate dehydratase activity GO:0004089 9.37 CA1 CA4
5 glycine binding GO:0016594 9.32 GRIN1 GRIN2B
6 ionotropic glutamate receptor activity GO:0004970 9.26 GRIN1 GRIN2B
7 glutamate binding GO:0016595 9.16 GRIN1 GRIN2B
8 NMDA glutamate receptor activity GO:0004972 8.96 GRIN1 GRIN2B
9 glutamate-gated calcium ion channel activity GO:0022849 8.62 GRIN1 GRIN2B
10 protein binding GO:0005515 10.21 CA1 CA4 CASP3 FOS GRIN1 GRIN2B

Sources for Occlusion Precerebral Artery

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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