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MCID: OCC016
MIFTS: 33

Occupational Asthma

Categories: Respiratory diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Occupational Asthma

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MalaCards integrated aliases for Occupational Asthma:

Name: Occupational Asthma 12 74

Classifications:

MalaCards categories:
Anatomical: Respiratory diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:0080820
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Summaries for Occupational Asthma

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Disease Ontology : 12 An environmental induced asthma that is characterized by a variable airflow limitation due to exposure to inhaled irritants in the workplace.

MalaCards based summary : Occupational Asthma is related to urticaria and latex allergy. An important gene associated with Occupational Asthma is IGHE (Immunoglobulin Heavy Constant Epsilon), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Allograft rejection. Affiliated tissues include skin, neutrophil and t cells.

Wikipedia : 74 Occupational asthma is new onset asthma or the recurrence of previously quiescent asthma directly caused... more...

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Related Diseases for Occupational Asthma

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Diseases related to Occupational Asthma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 165)
# Related Disease Score Top Affiliating Genes
1 urticaria 30.6 TPT1 IGHE
2 latex allergy 30.1 IGHE HLA-DQB1
3 food allergy 30.0 TPT1 IGHE
4 asthma 29.9 TPT1 IGHE HLA-DRB1 HLA-DQB1 HLA-DPB1 GSTP1
5 rhinitis 10.9
6 ige responsiveness, atopic 10.7
7 lung disease 10.6
8 allergic asthma 10.6
9 hypereosinophilic syndrome 10.5
10 allergic rhinitis 10.5
11 contact dermatitis 10.5
12 bronchitis 10.5
13 allergic disease 10.4
14 conjunctivitis 10.4
15 respiratory allergy 10.3
16 dermatitis 10.3
17 extrinsic allergic alveolitis 10.3
18 asthma-related traits 2 10.3
19 pollen allergy 10.3
20 allergic contact dermatitis 10.2
21 exanthem 10.2
22 pulmonary disease, chronic obstructive 10.1
23 asthma-related traits 4 10.1
24 acute asthma 10.1
25 silicosis 10.1
26 syphilis 10.1 IGHE HLA-DRB1
27 buerger disease 10.1 HLA-DRB1 HLA-DPB1
28 berylliosis 10.1 HLA-DRB1 HLA-DPB1
29 asthma-related traits 1 10.1
30 bronchiolitis 10.1
31 occupational dermatitis 10.1
32 limbic encephalitis with lgi1 antibodies 10.0 HLA-DRB1 HLA-DQB1
33 autoimmune polyglandular syndrome type 3 10.0 HLA-DRB1 HLA-DQB1
34 wheat allergy 10.0 IGHE HLA-DQB1
35 hypersomnia 10.0 HLA-DRB1 HLA-DQB1
36 narcolepsy 2 10.0 HLA-DRB1 HLA-DQB1
37 htlv-1 associated myelopathy/tropical spastic paraparesis 10.0 HLA-DRB1 HLA-DQB1
38 latent autoimmune diabetes in adults 10.0 HLA-DRB1 HLA-DQB1
39 primary adrenal insufficiency 10.0 HLA-DRB1 HLA-DQB1
40 recurrent respiratory papillomatosis 10.0 HLA-DRB1 HLA-DQB1
41 metal allergy 10.0 HLA-DRB1 HLA-DQB1
42 autoimmune hepatitis 10.0 HLA-DRB1 HLA-DQB1
43 autoimmune hepatitis type 1 10.0 HLA-DRB1 HLA-DQB1
44 focal epithelial hyperplasia 10.0 HLA-DRB1 HLA-DQB1
45 pediatric multiple sclerosis 10.0 HLA-DRB1 HLA-DQB1
46 podoconiosis 10.0 HLA-DRB1 HLA-DQB1
47 idiopathic nephrotic syndrome 10.0 HLA-DRB1 HLA-DQB1
48 osteonecrosis of the jaw 10.0 HLA-DRB1 HLA-DQB1
49 pityriasis rosea 10.0 HLA-DRB1 HLA-DQB1
50 narcolepsy 1 10.0 HLA-DRB1 HLA-DQB1

Graphical network of the top 20 diseases related to Occupational Asthma:



Diseases related to Occupational Asthma
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Symptoms & Phenotypes for Occupational Asthma

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Drugs & Therapeutics for Occupational Asthma

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Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Characterization of Phenotypes of Occupational Asthma: Descriptive Study Unknown status NCT03568305
2 Evolution of the Incidence of Occupational Asthma at the Beginning of the Activity of Young Bakers, Pastry-makers and Hairdressers, and Exploration of Its Risk Factors Completed NCT01096537
3 Community Based Study on Occupational Asthma Completed NCT00005755
4 Pilot Study of Metabolomics in Occupational Asthma Not yet recruiting NCT04301674
5 Comparative Study of Pathophysiological Mechanisms and Bronchial Response in Occupational Asthma to Wheat Flour and Quaternary Ammonium Compounds During Standardized Bronchial Provocation Tests Terminated NCT01783873

Search NIH Clinical Center for Occupational Asthma

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Genetic Tests for Occupational Asthma

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Anatomical Context for Occupational Asthma

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MalaCards organs/tissues related to Occupational Asthma:

40
Skin, Neutrophil, T Cells, Lung, Endothelial, Trachea, Lymph Node
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Publications for Occupational Asthma

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Articles related to Occupational Asthma:

(show top 50) (show all 2837)
# Title Authors PMID Year
1
Clinical Importance of Work-Exacerbated Asthma: Findings From a Prospective Asthma Cohort in a Highly Industrialized City in Korea. 61
33474860 2021
2
The effectiveness of removal from exposure and reduction of exposure for managing occupational asthma: Summary of an updated Cochrane systematic review. 61
33373055 2021
3
Airborne occupational exposures and inflammatory biomarkers in the Lifelines cohort study. 61
32769140 2021
4
Mapping Chemical Respiratory Sensitization: How Useful Are Our Current Computational Tools? 61
33320000 2021
5
Toluene diisocyanate-induced inflammation and airway remodeling involves autophagy in human bronchial epithelial cells. 61
33127434 2021
6
Novel approaches in occupational asthma diagnosis and management. 61
33141780 2021
7
Baker's asthma in bread factory workers. 61
33404390 2021
8
JNK modulates RAGE/β-catenin signaling and is essential for allergic airway inflammation in asthma. 61
33075463 2021
9
Occupational rhinitis. 61
33524079 2021
10
New causes of immunologic occupational asthma 2014-2020. 61
33332925 2020
11
A 2019 Update on Occupational Lung Diseases: A Narrative Review. 61
33385174 2020
12
Occupational respiratory and skin diseases among workers exposed to metalworking fluids. 61
33394701 2020
13
Occupational buckwheat allergy as a cause of allergic rhinitis, asthma, contact urticaria and anaphylaxis-An emerging problem in food-handling occupations? 61
32944967 2020
14
Assessment and Management of Occupational Asthma. 61
33161958 2020
15
A narrative review of research advances in mesenchymal stem cell therapy for asthma. 61
33313206 2020
16
Practical learnings from an epidemiology study on TDI-related occupational asthma: Part II-Exposure without respiratory protection to TWA-8 values indicative of peak events is a good indicator of risk. 61
32945732 2020
17
Practical learnings from an epidemiology study on TDI-related occupational asthma: Part I-Cumulative exposure is not a good indicator of risk. 61
32862785 2020
18
Exhaled nitric oxide is of limited value in the diagnosis of occupational asthma. 61
33242627 2020
19
Occupational Rhinitis. 61
32653647 2020
20
[A questionnaire assessing knowledge level concerning occupational asthma]. 61
33069502 2020
21
A case of lactoferrin-induced occupational asthma. 61
32835873 2020
22
Impact of Identification of Clinical Phenotypes in Occupational Asthma. 61
32561498 2020
23
Diagnosis of occupational asthma from serial measurements of forced expiratory volume in 1 s (FEV1) using the Area Between Curves (ABC) score from the Oasys plotter. 61
32764105 2020
24
On-site comparison of the OSHA 47, Asset EZ4-NCO, Iso-Chek, DAN, and CIP10 methods for measuring methylene diphenyl diisocyanate (MDI) at an oriented-strand board (OSB) factory. 61
33196402 2020
25
Identification of late asthmatic reactions following specific inhalation challenge. 61
32699009 2020
26
Occupational Asthma and Its Causation in the UK Seafood Processing Industry. 61
32491156 2020
27
Cobalt exposure via skin alters lung immune cells and enhances pulmonary responses to cobalt in mice. 61
32726143 2020
28
Innate lymphoid cells in isocyanate-induced asthma: role of microRNA-155. 61
32499335 2020
29
Four seasons of Czech asthma study: asthma characteristics and management reality in the Czech Republic. 61
31144543 2020
30
[Occupational medical pneumology - what's new?] 61
32791555 2020
31
The validity of the Canadian clinical scores for occupational asthma in European populations. 61
32242942 2020
32
Health Effects of Trimellitic Anhydride Occupational Exposure: Insights from Animal Models and Immunosurveillance Programs. 61
32594360 2020
33
Rhinoconjunctivitis and Occupational Asthma due to Buckwheat Flour Allergy. 61
32204953 2020
34
Is TLR4 Critical for Neutrophil Apoptosis in Occupational Asthma? 61
32400124 2020
35
Japanese guidelines for occupational allergic diseases 2020. 61
32471740 2020
36
Successful adjunctive treatment of compartment syndrome due to acute isocyanate inhalation using hyperbaric oxygen therapy: case report. 61
32931672 2020
37
Pine rosin identified as a toxic cannabis extract adulterant. 61
32460222 2020
38
Causes and Phenotypes of Work-Related Asthma. 61
32627764 2020
39
[Analysis of direct economic burden of occupational asthma]. 61
32629574 2020
40
Follow-up survey of patients with occupational asthma. 61
32307530 2020
41
Progress in Occupational Asthma. 61
32599814 2020
42
Occupational asthma and rhinitis due to wheat flour: sublingual specific immunotherapy treatment. 61
32624562 2020
43
Occupational Exposure to Metals and Solvents: Allergy and Airway Diseases. 61
32506296 2020
44
Molecular Characterization and Experimental Utility of Monoclonal Antibodies with Specificity for Aliphatic Di- and Polyisocyanates. 61
32302507 2020
45
A scoping review to identify strategies that work to prevent four important occupational diseases. 61
32227359 2020
46
[Recommendations for performing specific inhalation challenge tests: Polish experience in relation to the European Respiratory Society guideliness]. 61
32401234 2020
47
Exposures and urinary biomonitoring of aliphatic isocyanates in construction metal structure coating. 61
32120250 2020
48
Cutaneous sensitization to aziridine preceding the onset of occupational asthma. 61
32002545 2020
49
Prevention of baker's asthma. 61
31850920 2020
50
Occupational Asthma and Rhinitis due to Yellow and Red Henna in a Hairdresser. 61
31530513 2020
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Variations for Occupational Asthma

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Expression for Occupational Asthma

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Search GEO for disease gene expression data for Occupational Asthma.
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Pathways for Occupational Asthma

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Pathways related to Occupational Asthma according to GeneCards Suite gene sharing:

(show all 22)
# Super pathways Score Top Affiliating Genes
1
Cytokine Signaling in Immune system 65
Show member pathways
 12.99 IGHE HLA-DRB1 HLA-DQB1 HLA-DPB1
2
Allograft rejection 36 1
Show member pathways
 12.52 HLA-DRB1 HLA-DQB1 HLA-DPB1
3
Measles 36
Show member pathways
 12.49 HLA-DRB1 HLA-DQB1 HLA-DPB1
4
Herpes simplex virus 1 infection 36
12.46 HLA-DRB1 HLA-DQB1 HLA-DPB1
5
Th17 cell differentiation 36
Show member pathways
 12.28 HLA-DRB1 HLA-DQB1 HLA-DPB1
6
Interferon gamma signaling 65
Show member pathways
 12.23 HLA-DRB1 HLA-DQB1 HLA-DPB1
7
TCR signaling (REACTOME) 65
Show member pathways
 12.07 HLA-DRB1 HLA-DQB1 HLA-DPB1
8
Human T-cell leukemia virus 1 infection 36
12.05 HLA-DRB1 HLA-DQB1 HLA-DPB1
9
Toxoplasmosis 36
Show member pathways
 11.98 HLA-DRB1 HLA-DQB1 HLA-DPB1
10
Tuberculosis 36
11.94 HLA-DRB1 HLA-DQB1 HLA-DPB1
11
CD28 co-stimulation 65
Show member pathways
 11.91 HLA-DRB1 HLA-DQB1 HLA-DPB1
12
Phagosome 36
11.84 HLA-DRB1 HLA-DQB1 HLA-DPB1
13
Immune response NFAT in immune response 23
Show member pathways
 11.81 IGHE HLA-DRB1 HLA-DQB1 HLA-DPB1
14
Cell adhesion molecules 36
11.78 HLA-DRB1 HLA-DQB1 HLA-DPB1
15
S-1P Stimulated Signaling 63
11.62 HLA-DRB1 HLA-DQB1 HLA-DPB1
16
Translocation of ZAP-70 to Immunological synapse 65
Show member pathways
 11.62 HLA-DRB1 HLA-DQB1 HLA-DPB1
17
MHC class II antigen presentation 65
11.56 HLA-DRB1 HLA-DQB1 HLA-DPB1
18
Hematopoietic cell lineage 36
11.49 HLA-DRB1 HLA-DQB1 HLA-DPB1
19
CTLA4 Signaling 63
11.44 HLA-DRB1 HLA-DQB1
20
Staphylococcus aureus infection 36
11.42 HLA-DRB1 HLA-DQB1 HLA-DPB1
21
Rheumatoid arthritis 36
11.3 HLA-DRB1 HLA-DQB1 HLA-DPB1
22
G-protein signaling N-RAS regulation pathway 23
Show member pathways
 10.76 HLA-DRB1 HLA-DQB1 HLA-DPB1
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GO Terms for Occupational Asthma

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Cellular components related to Occupational Asthma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lysosome GO:0005764 9.65 HLA-DRB1 HLA-DQB1 HLA-DPB1
2 lysosomal membrane GO:0005765 9.63 HLA-DRB1 HLA-DQB1 HLA-DPB1
3 endosome membrane GO:0010008 9.61 HLA-DRB1 HLA-DQB1 HLA-DPB1
4 trans-Golgi network membrane GO:0032588 9.58 HLA-DRB1 HLA-DQB1 HLA-DPB1
5 endocytic vesicle membrane GO:0030666 9.54 HLA-DRB1 HLA-DQB1 HLA-DPB1
6 ER to Golgi transport vesicle membrane GO:0012507 9.5 HLA-DRB1 HLA-DQB1 HLA-DPB1
7 transport vesicle membrane GO:0030658 9.43 HLA-DRB1 HLA-DQB1 HLA-DPB1
8 clathrin-coated endocytic vesicle membrane GO:0030669 9.33 HLA-DRB1 HLA-DQB1 HLA-DPB1
9 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.13 HLA-DRB1 HLA-DQB1 HLA-DPB1
10 MHC class II protein complex GO:0042613 8.8 HLA-DRB1 HLA-DQB1 HLA-DPB1

Biological processes related to Occupational Asthma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.78 IGHE HLA-DRB1 HLA-DQB1 HLA-DPB1
2 immune response GO:0006955 9.73 IGHE HLA-DRB1 HLA-DQB1 HLA-DPB1
3 adaptive immune response GO:0002250 9.71 IGHE HLA-DRB1 HLA-DQB1 HLA-DPB1
4 T cell receptor signaling pathway GO:0050852 9.63 HLA-DRB1 HLA-DQB1 HLA-DPB1
5 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 9.54 HLA-DRB1 HLA-DQB1 HLA-DPB1
6 interferon-gamma-mediated signaling pathway GO:0060333 9.43 HLA-DRB1 HLA-DQB1 HLA-DPB1
7 humoral immune response mediated by circulating immunoglobulin GO:0002455 9.32 HLA-DRB1 HLA-DQB1
8 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 9.16 HLA-DRB1 HLA-DQB1
9 antigen processing and presentation GO:0019882 9.13 HLA-DRB1 HLA-DQB1 HLA-DPB1
10 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 8.8 HLA-DRB1 HLA-DQB1 HLA-DPB1

Molecular functions related to Occupational Asthma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MHC class II receptor activity GO:0032395 8.96 HLA-DRB1 HLA-DQB1
2 peptide antigen binding GO:0042605 8.8 HLA-DRB1 HLA-DQB1 HLA-DPB1
Sources

Sources for Occupational Asthma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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