Aliases & Classifications for Ocular Dominance

MalaCards integrated aliases for Ocular Dominance:

Name: Ocular Dominance 57 55

Characteristics:

OMIM:

57
Inheritance:
autosomal dominant


HPO:

32
ocular dominance:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM 57 164190
MedGen 42 C0422883
SNOMED-CT via HPO 69 263681008

Summaries for Ocular Dominance

MalaCards based summary : Ocular Dominance is related to fetal alcohol spectrum disorder and depression. An important gene associated with Ocular Dominance is GRIN1 (Glutamate Ionotropic Receptor NMDA Type Subunit 1), and among its related pathways/superpathways are PEDF Induced Signaling and CREB Pathway. The drugs Anesthetics and Phenylephrine have been mentioned in the context of this disorder. Affiliated tissues include cortex, eye and retina, and related phenotypes are Decreased caspase 3/7 activity and Reduced mammosphere formation

Wikipedia : 76 Ocular dominance, sometimes called eye preference or eyedness, is the tendency to prefer visual input... more...

Description from OMIM: 164190

Related Diseases for Ocular Dominance

Diseases related to Ocular Dominance via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 54)
# Related Disease Score Top Affiliating Genes
1 fetal alcohol spectrum disorder 29.6 GRIN2B GRIN2A BDNF
2 depression 29.5 NOS1 HTR2C BDNF
3 high pressure neurological syndrome 10.2 HTR2C GRIN1
4 bile acid synthesis defect, congenital, 1 10.2 GRIN2B GRIN2A
5 cerebral hypoxia 10.2 NOS1 CREB1
6 prurigo nodularis 10.1 NGFR NGF
7 epilepsy, focal, with speech disorder and with or without mental retardation 10.1 GRIN2B GRIN2A
8 amblyopia 10.1
9 neurogenic arthropathy 10.1 NGFR NGF
10 occlusion precerebral artery 10.1 GRIN2B GRIN1
11 jejunoileitis 10.0 NOS1 NGF
12 strabismus 10.0
13 cannabis abuse 10.0 NGF BDNF
14 diabetic autonomic neuropathy 10.0 NTF3 NGF
15 anisometropia 9.9
16 adult astrocytic tumour 9.9 NGF BDNF
17 amnestic disorder 9.9 CREB1 CHAT BDNF
18 benign epilepsy with centrotemporal spikes 9.9 GRIN2A GRIN1 BDNF
19 neuropathy, hereditary sensory and autonomic, type v 9.9 NGFR NGF BDNF
20 hirschsprung disease 1 9.9 NTF3 NOS1 NGFR
21 psychotic disorder 9.9 NOS1 HTR2C BDNF
22 valproate embryopathy 9.9 GRIN2B GRIN2A BDNF
23 pheochromocytoma 9.9 NGFR NGF EGR1 CREB1
24 cataract 9.9
25 central nervous system disease 9.8 NGF CHAT BDNF
26 obsessive-compulsive disorder 9.8 BDNF HTR2C GRIN2B
27 spinal cord injury 9.8 NOS1 NGFR GRIN1 BDNF
28 nervous system disease 9.8 NGF GRIN2B CHAT BDNF
29 temporal lobe epilepsy 9.8 GRIN1 GAD1 BDNF
30 myopia 9.8
31 mood disorder 9.8 NGFR HTR2C CREB1 BDNF
32 alcohol dependence 9.8 HTR2C GRIN2B GRIN2A BDNF
33 toxic encephalopathy 9.7 NGF GRIN2B GRIN2A CREB1 BDNF
34 amyotrophic lateral sclerosis 1 9.7 NOS1 NGFR NGF CHAT BDNF
35 aging 9.6
36 aphasia 9.6
37 suppression amblyopia 9.6
38 alternating exotropia 9.6
39 exotropia 9.6
40 presbyopia 9.6
41 retinal disease 9.6
42 refractive error 9.6
43 esotropia 9.6
44 huntington disease 9.6 GRIN2B GRIN2A GRIN1 CREB1 CHAT BDNF
45 parkinson disease, late-onset 9.6 NOS1 NGF GAD1 CHAT BDNF
46 major depressive disorder 9.6 HTR2C GRIN2B GAD1 CREB1 BDNF
47 disease of mental health 9.5 HTR2C GRIN2B GRIN2A GAD1 BDNF
48 epilepsy 9.5 SLC12A5 GRIN2B GRIN2A GAD1 BDNF
49 rett syndrome 9.5 SLC12A5 GRIN1 GAD1 CREB1 CHAT BDNF
50 autism 9.4 NTF3 GRIN2B GRIN2A GAD1 BDNF

Graphical network of the top 20 diseases related to Ocular Dominance:



Diseases related to Ocular Dominance

Symptoms & Phenotypes for Ocular Dominance

Symptoms via clinical synopsis from OMIM:

57
Head And Neck Eyes:
ocular dominance


Clinical features from OMIM:

164190

GenomeRNAi Phenotypes related to Ocular Dominance according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased caspase 3/7 activity GR00318-A 9.13 GRIN1 GRIN2A GRIN2B
2 Reduced mammosphere formation GR00396-S 9.1 BDNF GRIN1 GRIN2B HTR2C NTF3 SRF

MGI Mouse Phenotypes related to Ocular Dominance:

46 (show all 16)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.43 BDNF CHAT CREB1 EGR1 GAD1 GRIN1
2 growth/size/body region MP:0005378 10.38 BDNF CHAT CREB1 EGR1 GAD1 GRIN1
3 homeostasis/metabolism MP:0005376 10.32 BDNF CHAT CREB1 EGR1 GAD1 GRIN1
4 mortality/aging MP:0010768 10.32 BDNF CHAT CREB1 EGR1 GAD1 GRIN1
5 nervous system MP:0003631 10.28 BDNF CHAT CREB1 EGR1 GAD1 GRIN1
6 cardiovascular system MP:0005385 10.25 CHAT CREB1 EGR1 GRIN1 GRIN2B NGF
7 normal MP:0002873 10.07 BDNF CHAT CREB1 GAD1 GRIN1 NGF
8 muscle MP:0005369 10.06 CHAT CREB1 HTR2C NGF NGFR NOS1
9 integument MP:0010771 10.04 BDNF EGR1 GRIN2A HTR2C NGF NGFR
10 respiratory system MP:0005388 10 BDNF CHAT CREB1 EGR1 GAD1 GRIN1
11 no phenotypic analysis MP:0003012 9.95 BDNF GAD1 GRIN1 GRIN2B NGF NOS1
12 hearing/vestibular/ear MP:0005377 9.92 BDNF GRIN1 NGFR SLC12A5 SRF
13 reproductive system MP:0005389 9.92 BDNF CHAT CREB1 EGR1 GRIN1 NOS1
14 skeleton MP:0005390 9.7 CHAT CREB1 EGR1 GAD1 NGFR NOS1
15 vision/eye MP:0005391 9.28 BDNF CHAT EGR1 GRIN1 NGF NGFR
16 taste/olfaction MP:0005394 9.26 BDNF GAD1 GRIN1 NGFR

Drugs & Therapeutics for Ocular Dominance

Drugs for Ocular Dominance (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Anesthetics Phase 1, Phase 2
2
Phenylephrine Approved 59-42-7 6041
3
Oxymetazoline Approved, Investigational 1491-59-4 4636
4
Ephedrine Approved 299-42-3 9294
5
Pseudoephedrine Approved 90-82-4 7028
6 Autonomic Agents
7 Sympathomimetics
8 Vasoconstrictor Agents
9 Respiratory System Agents
10 Mydriatics
11 Nasal Decongestants
12 Adrenergic alpha-Agonists
13 Cardiotonic Agents
14 Neurotransmitter Agents
15 Adrenergic Agonists
16 Adrenergic Agents
17 Peripheral Nervous System Agents
18 Protective Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Show Improved Vision With the HOYA AF-1 Aspheric Intraocular Lens After Cataract Surgery Unknown status NCT01382641 Phase 4
2 A Prospective Study of Femtosecond Laser Intracorneal Lensectomi Completed NCT01673503 Phase 3
3 A First-in-human, Proof of Concept Study of CPK850 in Patients With RLBP1 Retinitis Pigmentosa Recruiting NCT03374657 Phase 1, Phase 2
4 Eyelid Position Interdependence in Involutional Ptosis Patients Submitted to 10% Phenylephrine Completed NCT00864656
5 Evaluation of the Aspheric ReSTOR IOL After Routine Cataract Extraction Completed NCT00720005
6 Project Gullstrand - European Project for the Determination of Average Biometric Values of Human Eyes Completed NCT01173614
7 Neuropsychological Evaluation of Psychiatric and Neurological Patients Completed NCT00001192

Search NIH Clinical Center for Ocular Dominance

Genetic Tests for Ocular Dominance

Anatomical Context for Ocular Dominance

MalaCards organs/tissues related to Ocular Dominance:

41
Cortex, Eye, Retina, Testes, Brain, Spinal Cord, Temporal Lobe

Publications for Ocular Dominance

Articles related to Ocular Dominance:

(show top 50) (show all 413)
# Title Authors Year
1
Cross-modal restoration of ocular dominance plasticity in adult mice. ( 29761580 )
2018
2
Long-Term Visual Training Increases Visual Acuity and Long-Term Monocular Deprivation Promotes Ocular Dominance Plasticity in Adult Standard Cage-Raised Mice. ( 29379877 )
2018
3
The Best of Both Worlds: Adaptation During Natural Tasks Produces Long-Lasting Plasticity in Perceptual Ocular Dominance. ( 29160741 )
2018
4
Hemifield columns co-opt ocular dominance column structure in human achiasma. ( 28017921 )
2018
5
Cross-Modal Reinstatement of Thalamocortical Plasticity Accelerates Ocular Dominance Plasticity in Adult Mice. ( 30257205 )
2018
6
Cross-modal Restoration of Juvenile-like Ocular Dominance Plasticity after Increasing GABAergic Inhibition. ( 30300702 )
2018
7
How Ocular Dominance and Binocularity Are Reflected by the Population Receptive Field Properties. ( 30398621 )
2018
8
The shift in ocular dominance from short-term monocular deprivation exhibits no dependence on duration of deprivation. ( 30459412 )
2018
9
Relationship between ocular dominance and brow position in patients with blepharoptosis. ( 29053045 )
2017
10
Ocular dominance plasticity: inhibitory interactions and contrast equivalence. ( 28071682 )
2017
11
The association between ocular dominance and physiological palpebral fissure asymmetry. ( 27461553 )
2017
12
Environmental enrichment accelerates ocular dominance plasticity in mouse visual cortex whereas transfer to standard cages resulted in a rapid loss of increased plasticity. ( 29073219 )
2017
13
Short-term monocular occlusion produces changes in ocular dominance by a reciprocal modulation of interocular inhibition. ( 28150723 )
2017
14
Sighting ocular dominance magnitude varies with test distance. ( 29090482 )
2017
15
GABAB receptor-dependent bidirectional regulation of critical period ocular dominance plasticity in cats. ( 28662175 )
2017
16
Lateral geniculate neurons projecting to primary visual cortex show ocular dominance plasticity in adult mice. ( 29184207 )
2017
17
The Cortical Mechanisms Underlying Ocular Dominance Plasticity in Adults are Not Orientationally Selective. ( 29111362 )
2017
18
Association of Visual Acuity with Ocular Dominance in 2045 Myopic Patients. ( 28494159 )
2017
19
Monocular Perceptual Deprivation from Interocular Suppression Temporarily Imbalances Ocular Dominance. ( 28262490 )
2017
20
Embryonic interneurons from the medial, but not the caudal ganglionic eminence trigger ocular dominance plasticity in adult mice. ( 27165433 )
2017
21
Aerobic Exercise Effects on Ocular Dominance Plasticity with a Phase Combination Task in Human Adults. ( 28357142 )
2017
22
Adaptive Neuromorphic Circuit for Stereoscopic Disparity Using Ocular Dominance Map. ( 27243029 )
2016
23
On the Maintenance of Normal Ocular Dominance and a Possible Mechanism Underlying Refractive Adaptation. ( 27699413 )
2016
24
Estimating the Binocular Visual Field of Glaucoma Patients With an Adjustment for Ocular Dominance. ( 27327583 )
2016
25
Association Between Ocular Dominance and Anisometropic Hyperopia. ( 27799584 )
2016
26
Macular pigment optical density: repeatability, intereye correlation, and effect of ocular dominance. ( 27621586 )
2016
27
Environmental enrichment preserved lifelong ocular dominance plasticity, but did not improve visual abilities. ( 27103526 )
2016
28
Nogo Receptor 1 Limits Ocular Dominance Plasticity but not Turnover of Axonal Boutons in a Model of Amblyopia. ( 25662716 )
2016
29
Ocular dominance, coexistent retinal disease, and refractive errors in patients with cataract surgery. ( 26632917 )
2016
30
Ocular Dominance Is Associated with the Ganglion Cell-Inner Plexiform Layer Thickness Profile in the Macula. ( 26918335 )
2016
31
Ocular Dominance Plasticity after Stroke Was Preserved in PSD-95 Knockout Mice. ( 26930616 )
2016
32
Ocular Dominance and Handedness in Golf Putting. ( 26398349 )
2015
33
The role of sensory ocular dominance on through-focus visual performance in monovision presbyopia corrections. ( 26024464 )
2015
34
Overexpression of Serum Response Factor in Neurons Restores Ocular Dominance Plasticity in a Model of Fetal Alcohol Spectrum Disorders. ( 26342644 )
2015
35
Ocular dominance plasticity disrupts binocular inhibition-excitation matching in visual cortex. ( 25754642 )
2015
36
A Small Motor Cortex Lesion Abolished Ocular Dominance Plasticity in the Adult Mouse Primary Visual Cortex and Impaired Experience-Dependent Visual Improvements. ( 26368569 )
2015
37
Metabotropic glutamate receptor signaling is required for NMDA receptor-dependent ocular dominance plasticity and LTD in visual cortex. ( 26417096 )
2015
38
Structural asymmetry of cortical visual areas is related to ocular dominance. ( 26509548 )
2015
39
The effect of cataract surgery on ocular dominance. ( 26715837 )
2015
40
False amblyopia prediction in strabismic patients byA fixation preference testing correlates with contralateral ocular dominance. ( 25266829 )
2014
41
Effects of ocular dominance on contrast sensitivity in middle-aged people. ( 24734197 )
2014
42
Environmental enrichment extends ocular dominance plasticity into adulthood and protects from stroke-induced impairments of plasticity. ( 24395770 )
2014
43
Identification of ocular dominance domains in New World owl monkeys by immediate-early gene expression. ( 24591618 )
2014
44
Social experience modulates ocular dominance plasticity differentially in adult male and female mice. ( 25173416 )
2014
45
Brief dark exposure restored ocular dominance plasticity in aging mice and after a cortical stroke. ( 25220148 )
2014
46
Voluntary physical exercise promotes ocular dominance plasticity in adult mouse primary visual cortex. ( 25392514 )
2014
47
Macular asymmetry analysis in sighting ocular dominance. ( 25438685 )
2014
48
No Evidence for Genetic Contribution of Ocular Dominance: The Guangzhou Twin Eye Study. ( 26107305 )
2014
49
A molecular correlate of ocular dominance columns in the developing mammalian visual cortex. ( 22892426 )
2013
50
c-Fos activity mapping reveals differential effects of noradrenaline and serotonin depletion on the regulation of ocular dominance plasticity in rats. ( 23333670 )
2013

Variations for Ocular Dominance

Expression for Ocular Dominance

Search GEO for disease gene expression data for Ocular Dominance.

Pathways for Ocular Dominance

Pathways related to Ocular Dominance according to GeneCards Suite gene sharing:

(show all 49)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.61 BDNF CREB1 GRIN1 GRIN2A GRIN2B NGF
2
Show member pathways
13.17 BDNF CREB1 GRIN1 GRIN2A GRIN2B HTR2C
3
Show member pathways
13.01 CREB1 GRIN1 GRIN2A GRIN2B NGF
4
Show member pathways
12.99 CHAT CREB1 GRIN1 GRIN2A GRIN2B NOS1
5
Show member pathways
12.98 BDNF CREB1 NGF NGFR NTF3
6
Show member pathways
12.97 CHAT CREB1 GAD1 GRIN1 GRIN2A GRIN2B
7
Show member pathways
12.91 BDNF CREB1 NGF NGFR NTF3
8 12.73 BDNF NGF NGFR NTF3 SRF
9
Show member pathways
12.67 BDNF CREB1 EGR1 NGF NGFR NTF3
10
Show member pathways
12.62 BDNF NGF NGFR NTF3
11
Show member pathways
12.6 BDNF CREB1 GRIN1 GRIN2A GRIN2B NOS1
12
Show member pathways
12.55 BDNF NGF NGFR NTF3
13
Show member pathways
12.55 BDNF GRIN1 GRIN2A GRIN2B NGF NGFR
14 12.33 CREB1 GRIN1 GRIN2A GRIN2B NOS1
15
Show member pathways
12.26 BDNF CREB1 GRIN1 GRIN2A GRIN2B
16
Show member pathways
12.24 BDNF EGR1 NGF NGFR NTF3
17
Show member pathways
12.23 GRIN1 GRIN2A HTR2C NOS1
18
Show member pathways
12.21 CREB1 GRIN1 GRIN2A GRIN2B
19
Show member pathways
12.12 CREB1 NGF NGFR SRF
20
Show member pathways
12.11 CREB1 GRIN1 GRIN2A GRIN2B SRF
21
Show member pathways
12 BDNF NGF NGFR NTF3
22
Show member pathways
11.97 GRIN1 GRIN2A GRIN2B
23
Show member pathways
11.96 GRIN1 GRIN2A GRIN2B NOS1
24 11.95 BDNF EGR1 GRIN1 NGFR NOS1
25 11.92 BDNF NGF NGFR
26
Show member pathways
11.92 BDNF CREB1 GRIN1 GRIN2A GRIN2B
27 11.86 CREB1 EGR1 GAD1 GRIN1 GRIN2A GRIN2B
28 11.85 CREB1 EGR1 SRF
29
Show member pathways
11.85 CREB1 GRIN1 GRIN2A GRIN2B
30 11.85 BDNF CHAT CREB1 EGR1 GRIN1 NGF
31 11.72 BDNF CREB1 EGR1 GRIN1 GRIN2B NGF
32 11.71 GRIN1 GRIN2A GRIN2B
33
Show member pathways
11.67 BDNF NGF NGFR NTF3
34 11.62 BDNF CREB1 GAD1 GRIN1
35
Show member pathways
11.6 BDNF NGF NGFR NTF3
36 11.55 BDNF CHAT GAD1 NGF NTF3
37 11.48 BDNF NGF NTF3
38 11.42 GRIN1 GRIN2A GRIN2B
39 11.33 BDNF CREB1 GRIN1
40 11.3 CREB1 EGR1 NGF
41
Show member pathways
11.2 CREB1 EGR1 NTF3 SRF
42 11.14 BDNF CREB1
43 11.1 GRIN1 GRIN2A GRIN2B
44 11.09 GRIN1 GRIN2A GRIN2B NOS1
45
Show member pathways
11.04 CHAT GAD1
46 11.04 CREB1 EGR1 SRF
47 10.99 CREB1 SRF
48 10.99 HTR2C SRF
49 10.82 BDNF CREB1

GO Terms for Ocular Dominance

Cellular components related to Ocular Dominance according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.93 GRIN1 GRIN2A GRIN2B HTR2C NGFR SLC12A5
2 synapse GO:0045202 9.8 GAD1 GRIN1 GRIN2A GRIN2B NOS1
3 neuron projection GO:0043005 9.78 CHAT GRIN1 GRIN2A GRIN2B
4 dendrite GO:0030425 9.77 BDNF GRIN1 HTR2C NGF NTF3
5 postsynaptic density GO:0014069 9.73 GRIN1 GRIN2A GRIN2B NOS1
6 axon GO:0030424 9.72 BDNF CREB1 GAD1 NGF NTF3
7 synaptic membrane GO:0097060 9.43 GRIN1 GRIN2A GRIN2B
8 postsynaptic density membrane GO:0098839 9.33 GRIN1 GRIN2A GRIN2B
9 NMDA selective glutamate receptor complex GO:0017146 9.13 GRIN1 GRIN2A GRIN2B
10 synaptic vesicle GO:0008021 9.02 BDNF GRIN1 GRIN2A NGF NTF3

Biological processes related to Ocular Dominance according to GeneCards Suite gene sharing:

(show all 34)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of apoptotic process GO:0043065 9.96 CREB1 GRIN1 GRIN2A NGF NGFR
2 response to drug GO:0042493 9.92 CREB1 GAD1 GRIN2A HTR2C SLC12A5
3 response to hypoxia GO:0001666 9.88 CREB1 EGR1 NOS1 SRF
4 negative regulation of neuron apoptotic process GO:0043524 9.85 BDNF GRIN1 NGF NTF3
5 chemical synaptic transmission GO:0007268 9.85 GAD1 GRIN2A GRIN2B HTR2C SLC12A5
6 response to ethanol GO:0045471 9.83 GRIN1 GRIN2A GRIN2B
7 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.81 BDNF NGF NTF3
8 calcium-mediated signaling GO:0019722 9.81 GRIN1 GRIN2A GRIN2B
9 excitatory postsynaptic potential GO:0060079 9.79 GRIN1 GRIN2A GRIN2B
10 neuron projection morphogenesis GO:0048812 9.79 BDNF NGF NTF3
11 learning GO:0007612 9.78 GRIN1 GRIN2A SLC12A5
12 learning or memory GO:0007611 9.77 GRIN1 GRIN2A GRIN2B
13 regulation of synaptic plasticity GO:0048167 9.77 GRIN1 GRIN2A GRIN2B
14 visual learning GO:0008542 9.76 CREB1 GRIN1 GRIN2A
15 cellular response to amyloid-beta GO:1904646 9.71 GRIN1 GRIN2A NGFR
16 peripheral nervous system development GO:0007422 9.69 BDNF NGF NTF3
17 regulation of neuron differentiation GO:0045664 9.67 BDNF NGF NTF3
18 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.66 NGFR SRF
19 positive regulation of long-term synaptic potentiation GO:1900273 9.66 CREB1 GRIN2A
20 startle response GO:0001964 9.65 GRIN1 GRIN2A
21 glutamate receptor signaling pathway GO:0007215 9.65 GRIN2A GRIN2B
22 ionotropic glutamate receptor signaling pathway GO:0035235 9.65 GRIN1 GRIN2A GRIN2B
23 regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043281 9.64 NGF NGFR
24 positive regulation of cysteine-type endopeptidase activity GO:2001056 9.63 GRIN1 GRIN2B
25 positive regulation of collateral sprouting GO:0048672 9.62 BDNF NGF
26 modulation of chemical synaptic transmission GO:0050804 9.62 BDNF GRIN2A NGF NTF3
27 neurotrophin TRK receptor signaling pathway GO:0048011 9.61 BDNF NGF NGFR
28 nerve development GO:0021675 9.58 BDNF NGF NTF3
29 protein localization to postsynaptic membrane GO:1903539 9.57 GRIN1 GRIN2A
30 neurotransmitter biosynthetic process GO:0042136 9.54 CHAT GAD1 NOS1
31 nerve growth factor signaling pathway GO:0038180 9.43 BDNF NGF NTF3
32 excitatory chemical synaptic transmission GO:0098976 9.33 GRIN1 GRIN2A GRIN2B
33 calcium ion transmembrane import into cytosol GO:0097553 9.13 GRIN1 GRIN2A GRIN2B
34 memory GO:0007613 9.1 BDNF CREB1 GRIN1 GRIN2A NGF NTF3

Molecular functions related to Ocular Dominance according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.67 BDNF NGF NTF3
2 ion channel activity GO:0005216 9.63 GRIN1 GRIN2A GRIN2B
3 signaling receptor activity GO:0038023 9.62 GRIN1 GRIN2A GRIN2B NGFR
4 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.58 GRIN1 GRIN2A GRIN2B
5 cation channel activity GO:0005261 9.48 GRIN1 GRIN2A
6 transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000982 9.43 EGR1 SRF
7 ionotropic glutamate receptor activity GO:0004970 9.43 GRIN1 GRIN2A GRIN2B
8 glycine binding GO:0016594 9.37 GRIN1 GRIN2B
9 glutamate binding GO:0016595 9.33 GAD1 GRIN1 GRIN2B
10 NMDA glutamate receptor activity GO:0004972 9.13 GRIN1 GRIN2A GRIN2B
11 glutamate-gated calcium ion channel activity GO:0022849 8.8 GRIN1 GRIN2A GRIN2B

Sources for Ocular Dominance

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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