Aliases & Classifications for Ocular Dominance

MalaCards integrated aliases for Ocular Dominance:

Name: Ocular Dominance 57 54

Characteristics:

OMIM®:

57 (Updated 20-May-2021)
Inheritance:
autosomal dominant


HPO:

31
ocular dominance:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM® 57 164190
MedGen 41 C0422883
SNOMED-CT via HPO 68 263681008

Summaries for Ocular Dominance

MalaCards based summary : Ocular Dominance is related to fetal alcohol syndrome and fetal alcohol spectrum disorder. An important gene associated with Ocular Dominance is GRIN1 (Glutamate Ionotropic Receptor NMDA Type Subunit 1), and among its related pathways/superpathways are PEDF Induced Signaling and CREB Pathway. The drug Mydriatics has been mentioned in the context of this disorder. Affiliated tissues include cortex, eye and brain, and related phenotypes are Decreased caspase 3/7 activity and Reduced mammosphere formation

Wikipedia : 73 Ocular dominance, sometimes called eye preference or eyedness, is the tendency to prefer visual input... more...

More information from OMIM: 164190

Related Diseases for Ocular Dominance

Diseases related to Ocular Dominance via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 130)
# Related Disease Score Top Affiliating Genes
1 fetal alcohol syndrome 29.9 GRIN2B GRIN2A BDNF
2 fetal alcohol spectrum disorder 29.6 GRIN2B GRIN2A CREB1 BDNF
3 aphasia 29.5 GRIN2A GRIN1 BDNF
4 suppression amblyopia 10.5
5 amblyopia 10.5
6 strabismus 10.5
7 mechanical strabismus 10.5
8 anisometropia 10.4
9 refractive error 10.4
10 cerebral hypoxia 10.3 NOS1 CREB1
11 autosomal dominant non-syndromic intellectual disability 6 10.3 GRIN2B GRIN1
12 prurigo nodularis 10.2 NGFR NGF
13 hand skill, relative 10.2
14 epilepsy, focal, with speech disorder and with or without mental retardation 10.2 GRIN2B GRIN2A
15 landau-kleffner syndrome 10.2 GRIN2B GRIN2A
16 high pressure neurological syndrome 10.2 HTR2C GRIN2A GRIN1
17 human t-cell leukemia virus type 1 10.1 SRF CREB1
18 astigmatism 10.1
19 cycloplegia 10.1
20 presbyopia 10.1
21 myopia 10.1
22 cataract 10.1
23 posttransplant acute limbic encephalitis 10.1
24 paroxysmal dystonia 10.1 NOS1 GRIN2B
25 prion disease 10.1 GRIN2B GRIN2A CREB1
26 monocular esotropia 10.1
27 esotropia 10.1
28 diabetic polyneuropathy 10.0 NTF3 NOS1 NGF
29 lingual-facial-buccal dyskinesia 10.0 HTR2C GRIN2B GRIN2A GRIN1
30 vascular dementia 10.0 NGF GRIN2B GRIN2A CHAT
31 alternating exotropia 10.0
32 exotropia 10.0
33 eye disease 10.0
34 herpes simplex 10.0
35 pathologic nystagmus 10.0
36 adrenal gland pheochromocytoma 10.0 NGF BDNF
37 myofascial pain syndrome 10.0 NGF BDNF
38 asphyxia neonatorum 9.9 NOS1 BDNF
39 diabetic neuropathy 9.9 NTF3 NGFR NGF
40 mild cognitive impairment 9.9 CHAT BDNF
41 dravet syndrome 9.9 SLC12A5 GRIN2B GRIN2A GRIN1
42 tendinosis 9.9 CHAT BDNF
43 dissociative disorder 9.9 GRIN2B BDNF
44 speech disorder 9.9 GRIN2B GRIN2A GAD1
45 trigeminal nerve disease 9.9 NGF BDNF
46 diabetic encephalopathy 9.9 NGF CREB1 BDNF
47 diabetic autonomic neuropathy 9.9 NTF3 NGF
48 neurotic disorder 9.9 NGF CHAT BDNF
49 occlusion precerebral artery 9.9 GRIN2B BDNF
50 thiamine deficiency disease 9.9 NGF CHAT BDNF

Graphical network of the top 20 diseases related to Ocular Dominance:



Diseases related to Ocular Dominance

Symptoms & Phenotypes for Ocular Dominance

Symptoms via clinical synopsis from OMIM®:

57 (Updated 20-May-2021)
Head And Neck Eyes:
ocular dominance

Clinical features from OMIM®:

164190 (Updated 20-May-2021)

GenomeRNAi Phenotypes related to Ocular Dominance according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased caspase 3/7 activity GR00318-A 9.13 GRIN1 GRIN2A GRIN2B
2 Reduced mammosphere formation GR00396-S 9.1 BDNF GRIN1 GRIN2B HTR2C NTF3 SRF

MGI Mouse Phenotypes related to Ocular Dominance:

46 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.4 BDNF CHAT CREB1 EGR1 GAD1 GRIN1
2 growth/size/body region MP:0005378 10.34 BDNF CHAT CREB1 EGR1 GAD1 GRIN1
3 mortality/aging MP:0010768 10.3 BDNF CHAT CREB1 EGR1 GAD1 GRIN1
4 homeostasis/metabolism MP:0005376 10.29 BDNF CHAT CREB1 EGR1 GAD1 GRIN1
5 nervous system MP:0003631 10.25 BDNF CHAT CREB1 EGR1 GAD1 GRIN1
6 cardiovascular system MP:0005385 10.21 CHAT CREB1 EGR1 GRIN1 NGF NGFR
7 muscle MP:0005369 10.03 CHAT CREB1 HTR2C NGF NGFR NOS1
8 normal MP:0002873 10.02 BDNF CHAT CREB1 GAD1 GRIN1 NGF
9 no phenotypic analysis MP:0003012 9.91 BDNF GAD1 GRIN1 GRIN2B NGF NOS1
10 respiratory system MP:0005388 9.9 BDNF CHAT CREB1 EGR1 GAD1 GRIN1
11 reproductive system MP:0005389 9.86 BDNF CHAT CREB1 EGR1 GRIN1 NOS1
12 vision/eye MP:0005391 9.28 BDNF CHAT EGR1 GRIN1 NGF NGFR
13 taste/olfaction MP:0005394 9.26 BDNF GAD1 GRIN1 NGFR

Drugs & Therapeutics for Ocular Dominance

Drugs for Ocular Dominance (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Mydriatics

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Prospective School-based Study of Myopia in Children in Southern China Recruiting NCT04219228

Search NIH Clinical Center for Ocular Dominance

Genetic Tests for Ocular Dominance

Anatomical Context for Ocular Dominance

MalaCards organs/tissues related to Ocular Dominance:

40
Cortex, Eye, Brain, Spinal Cord, Retina, Thalamus, Endothelial

Publications for Ocular Dominance

Articles related to Ocular Dominance:

(show top 50) (show all 1452)
# Title Authors PMID Year
1
Inheritance of ocular dominance. 57 61
697699 1978
2
A semi-persistent adult ocular dominance plasticity in visual cortex is stabilized by activated CREB. 61 54
15537732 2004
3
Different mechanisms for loss and recovery of binocularity in the visual cortex. 61 54
12388608 2002
4
cAMP/Ca2+ response element-binding protein function is essential for ocular dominance plasticity. 61 54
11896163 2002
5
Infusion of nerve growth factor (NGF) into kitten visual cortex increases immunoreactivity for NGF, NGF receptors, and choline acetyltransferase in basal forebrain without affecting ocular dominance plasticity or column development. 54 61
11738495 2001
6
The effects of panretinal photocoagulation on the primary visual cortex of the adult monkey. 61 54
11797318 2001
7
Dynamic regulation of BDNF and NT-3 expression during visual system development. 54 61
10745216 2000
8
Patchy distribution of NMDAR1 subunit immunoreactivity in developing visual cortex. 54 61
9547247 1998
9
Inhibition of nitric oxide synthase does not prevent ocular dominance plasticity in kitten visual cortex. 54 61
8842009 1996
10
Brain-derived neurotrophic factor reversed experience-dependent synaptic modifications in kitten visual cortex. 54 61
8758963 1996
11
Activity-dependent changes in GAD and preprotachykinin mRNAs in visual cortex of adult monkeys. 61 54
8180490 1994
12
Activity-dependent expression of the transcription factor Zif268 reveals ocular dominance columns in monkey visual cortex. 61 54
8481787 1993
13
The role of afferent activity in the maintenance of primate neocorticalfunction. 61 54
2177767 1990
14
Selective serotonin reuptake inhibitors for functional recovery after stroke: similarities with the critical period and the role of experience-dependent plasticity. 61
31346698 2021
15
Point-spread function of the BOLD response across columns and cortical depth in human extra-striate cortex. 61
33741401 2021
16
The ups and downs of sensory eye balance: Monocular deprivation has a biphasic effect on interocular dominance. 61
33684826 2021
17
Spine dynamics of PSD-95-deficient neurons in the visual cortex link silent synapses to structural cortical plasticity. 61
33649238 2021
18
Astrocyte glutamate uptake coordinates experience-dependent, eye-specific refinement in developing visual cortex. 61
33675674 2021
19
Impairment of visual cortical plasticity by amyloid-beta species. 61
33766652 2021
20
Relationship of Sighting Ocular Dominance with Macular Photostress Test Time and Thickness of the Middle Macular Layers. 61
33633023 2021
21
Author Correction: Short-term monocular occlusion produces changes in ocular dominance by a reciprocal modulation of interocular inhibition. 61
33785806 2021
22
Ultra-high field fMRI reveals origins of feedforward and feedback activity within laminae of human ocular dominance columns. 61
33385565 2021
23
Ocular dominance columns in V1 are more susceptible than associated callosal patches to imbalance of eye input during precritical and critical periods. 61
33683706 2021
24
Chondroitinase and Antidepressants Promote Plasticity by Releasing TRKB from Dephosphorylating Control of PTPσ in Parvalbumin Neurons. 61
33293360 2021
25
Functional Differentiation of Mouse Visual Cortical Areas Depends upon Early Binocular Experience. 61
33376158 2021
26
Loss of P2Y12 Has Behavioral Effects in the Adult Mouse. 61
33668516 2021
27
Microstructural properties of major white matter tracts in constant exotropia before and after strabismus surgery. 61
33468491 2021
28
Projection of Orthogonal Tiling from the Retina to the Visual Cortex. 61
33406438 2021
29
The effect of ocular dominance on macular function: A pattern electroretinogram study. 61
33353418 2020
30
Ocular dominance plasticity: Molecular mechanisms revisited. 61
32737874 2020
31
Phosphoinositide-3-Kinase γ Is Not a Predominant Regulator of ATP-Dependent Directed Microglial Process Motility or Experience-Dependent Ocular Dominance Plasticity. 61
33067365 2020
32
A sex-dependent delayed maturation of visual plasticity induced by adverse experiences in early childhood. 61
33344711 2020
33
MiR-29 coordinates age-dependent plasticity brakes in the adult visual cortex. 61
33026181 2020
34
Precise levels of nectin-3 are required for proper synapse formation in postnatal visual cortex. 61
33160402 2020
35
Disparity Sensitivity and Binocular Integration in Mouse Visual Cortex Areas. 61
33051348 2020
36
Brief localised monocular deprivation in adults alters binocular rivalry predominance retinotopically and reduces spatial inhibition. 61
33127963 2020
37
Eye-selective fMRI activity in human primary visual cortex: Comparison between 3 ​T and 9.4 ​T, and effects across cortical depth. 61
32585340 2020
38
Depletion of microglia in developing cortical circuits reveals its critical role in glutamatergic synapse development, functional connectivity, and critical period plasticity. 61
32594561 2020
39
[Association between ocular dominance and refraction in myopic subjects]. 61
32907303 2020
40
Layer 4 Gates Plasticity in Visual Cortex Independent of a Canonical Microcircuit. 61
32589913 2020
41
Glomerulus-Selective Regulation of a Critical Period for Interneuron Plasticity in the Drosophila Antennal Lobe. 61
32532889 2020
42
Disruption of Critical Period Plasticity in a Mouse Model of Neurofibromatosis Type 1. 61
32527982 2020
43
Activation of Somatostatin Interneurons by Nicotinic Modulator Lypd6 Enhances Plasticity and Functional Recovery in the Adult Mouse Visual Cortex. 61
32467358 2020
44
Running towards amblyopia recovery. 61
32728106 2020
45
Using psychophysical performance to predict short-term ocular dominance plasticity in human adults. 61
32634225 2020
46
Functional ultrasound imaging of deep visual cortex in awake nonhuman primates. 61
32513717 2020
47
Natural-scene-based Steady-state Visual Evoked Potentials Reveal Effects of Short-term Monocular Deprivation. 61
32229234 2020
48
Eye-dominance-guided Foveated Rendering. 61
32086213 2020
49
Ring models of binocular rivalry and fusion. 61
32363561 2020
50
Action Video Gaming Does Not Influence Short-Term Ocular Dominance Plasticity in Visually Normal Adults. 61
32345735 2020

Variations for Ocular Dominance

Expression for Ocular Dominance

Search GEO for disease gene expression data for Ocular Dominance.

Pathways for Ocular Dominance

Pathways related to Ocular Dominance according to GeneCards Suite gene sharing:

(show all 50)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.62 SRF NOS1 NGFR NGF GRIN2B GRIN2A
2
Show member pathways
13.17 NTF3 NGFR NGF HTR2C GRIN2B GRIN2A
3
Show member pathways
13.01 NGF GRIN2B GRIN2A GRIN1 CREB1
4
Show member pathways
13 NOS1 GRIN2B GRIN2A GRIN1 CREB1 CHAT
5
Show member pathways
12.99 NTF3 NGFR NGF CREB1 BDNF
6
Show member pathways
12.98 GRIN2B GRIN2A GRIN1 GAD1 CREB1 CHAT
7
Show member pathways
12.92 NTF3 NGFR NGF CREB1 BDNF
8
Show member pathways
12.78 GRIN2B GRIN2A GRIN1 EGR1 CREB1
9 12.73 SRF NTF3 NGFR NGF BDNF
10
Show member pathways
12.65 NTF3 NGFR NGF EGR1 CREB1 BDNF
11
Show member pathways
12.63 NTF3 NGFR NGF BDNF
12
Show member pathways
12.59 NOS1 GRIN2B GRIN2A GRIN1 CREB1 BDNF
13
Show member pathways
12.56 NTF3 NGFR NGF GRIN2B GRIN2A GRIN1
14
Show member pathways
12.53 NTF3 NGFR NGF BDNF
15 12.37 NOS1 NGF HTR2C GRIN2A GRIN1
16 12.33 NOS1 GRIN2B GRIN2A GRIN1 CREB1
17 12.29 GRIN2B GRIN2A GRIN1 CREB1 BDNF
18
Show member pathways
12.25 NTF3 NGFR NGF EGR1 BDNF
19
Show member pathways
12.22 GRIN2B GRIN2A GRIN1 CREB1
20
Show member pathways
12.13 SRF NGFR NGF CREB1
21 12.12 NOS1 GRIN2B GRIN2A GRIN1
22 12.03 GRIN2B GRIN2A GRIN1
23
Show member pathways
11.98 GRIN2B GRIN2A GRIN1
24
Show member pathways
11.95 GRIN2B GRIN2A GRIN1 CREB1
25 11.95 NOS1 NGFR GRIN1 EGR1 BDNF
26 11.93 NGFR NGF BDNF
27
Show member pathways
11.93 GRIN2B GRIN2A GRIN1 CREB1 BDNF
28 11.86 SRF EGR1 CREB1
29
Show member pathways
11.86 GRIN2B GRIN2A GRIN1 CREB1
30 11.86 SLC12A5 NOS1 NGFR NGF GRIN2B GRIN2A
31 11.84 NGF GRIN1 EGR1 CREB1 CHAT BDNF
32
Show member pathways
11.78 NTF3 NGFR NGF BDNF
33 11.72 GRIN2B GRIN2A GRIN1
34 11.72 NTF3 NGFR NGF GRIN2B GRIN1 EGR1
35
Show member pathways
11.66 NTF3 NGFR NGF BDNF
36 11.6 GRIN1 GAD1 CREB1 BDNF
37
Show member pathways
11.58 NTF3 NGFR NGF BDNF
38 11.55 NTF3 NGF GAD1 CHAT BDNF
39 11.43 GRIN2B GRIN2A GRIN1
40 11.33 GRIN1 CREB1 BDNF
41 11.31 NGF EGR1 CREB1
42
Show member pathways
11.2 SRF NTF3 EGR1 CREB1
43 11.19 GRIN2B GRIN2A GRIN1
44 11.1 GRIN2B GRIN2A GRIN1
45 11.09 NOS1 GRIN2B GRIN2A GRIN1
46
Show member pathways
11.05 GAD1 CHAT
47 11.04 SRF EGR1 CREB1
48 11 SRF HTR2C
49 11 SRF CREB1
50 10.83 CREB1 BDNF

GO Terms for Ocular Dominance

Cellular components related to Ocular Dominance according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.95 SLC12A5 NGFR HTR2C GRIN2B GRIN2A GRIN1
2 dendrite GO:0030425 9.85 NTF3 NGF HTR2C GRIN1 BDNF
3 neuron projection GO:0043005 9.83 SLC12A5 GRIN2B GRIN2A GRIN1 CHAT
4 axon GO:0030424 9.8 NTF3 NGF GAD1 CREB1 BDNF
5 dendritic spine GO:0043197 9.67 NOS1 NGFR GRIN2A GRIN1
6 postsynaptic density GO:0014069 9.65 NOS1 NGFR GRIN2B GRIN2A GRIN1
7 synaptic membrane GO:0097060 9.5 GRIN2B GRIN2A GRIN1
8 synaptic vesicle GO:0008021 9.35 NTF3 NGF GRIN2A GRIN1 BDNF
9 NMDA selective glutamate receptor complex GO:0017146 9.33 GRIN2B GRIN2A GRIN1
10 synapse GO:0045202 9.28 SLC12A5 NOS1 NGFR HTR2C GRIN2B GRIN2A

Biological processes related to Ocular Dominance according to GeneCards Suite gene sharing:

(show all 33)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of apoptotic process GO:0043065 9.95 NGFR NGF GRIN2A CREB1
2 response to drug GO:0042493 9.91 SLC12A5 HTR2C GRIN2A GAD1 CREB1
3 response to hypoxia GO:0001666 9.88 SRF NOS1 EGR1 CREB1
4 rhythmic process GO:0048511 9.83 NGFR EGR1 CREB1
5 negative regulation of neuron apoptotic process GO:0043524 9.83 NTF3 NGF BDNF
6 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.82 NTF3 NGF BDNF
7 response to ethanol GO:0045471 9.82 GRIN2B GRIN2A GRIN1
8 calcium-mediated signaling GO:0019722 9.8 GRIN2B GRIN2A GRIN1
9 neuron projection morphogenesis GO:0048812 9.78 NTF3 NGF BDNF
10 excitatory postsynaptic potential GO:0060079 9.77 GRIN2B GRIN2A GRIN1
11 regulation of synaptic plasticity GO:0048167 9.77 GRIN2B GRIN2A GRIN1
12 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.76 NTF3 NOS1 NGF BDNF
13 cellular response to amyloid-beta GO:1904646 9.75 NGFR GRIN2A GRIN1
14 visual learning GO:0008542 9.74 GRIN2A GRIN1 CREB1
15 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.73 SRF NGFR EGR1
16 modulation of chemical synaptic transmission GO:0050804 9.73 NTF3 NGF GRIN2A BDNF
17 regulation of neuron differentiation GO:0045664 9.72 NTF3 NGF BDNF
18 regulation of NMDA receptor activity GO:2000310 9.71 GRIN2B GRIN2A GRIN1
19 peripheral nervous system development GO:0007422 9.7 NTF3 NGF BDNF
20 ionotropic glutamate receptor signaling pathway GO:0035235 9.67 GRIN2B GRIN2A GRIN1
21 neurotrophin TRK receptor signaling pathway GO:0048011 9.65 NGFR NGF BDNF
22 glutamate receptor signaling pathway GO:0007215 9.64 GRIN2B GRIN2A
23 protein heterotetramerization GO:0051290 9.63 GRIN2B GRIN1
24 regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043281 9.63 NGFR NGF
25 chemical synaptic transmission GO:0007268 9.63 SLC12A5 HTR2C GRIN2B GRIN2A GRIN1 GAD1
26 positive regulation of cysteine-type endopeptidase activity GO:2001056 9.62 GRIN2B GRIN1
27 positive regulation of collateral sprouting GO:0048672 9.61 NGF BDNF
28 neurotransmitter biosynthetic process GO:0042136 9.58 NOS1 GAD1 CHAT
29 nerve growth factor signaling pathway GO:0038180 9.54 NTF3 NGF BDNF
30 excitatory chemical synaptic transmission GO:0098976 9.5 GRIN2B GRIN2A GRIN1
31 calcium ion transmembrane import into cytosol GO:0097553 9.43 GRIN2B GRIN2A GRIN1
32 memory GO:0007613 9.35 NTF3 NGF GRIN2A CREB1 BDNF
33 nerve development GO:0021675 8.92 NTF3 NGFR NGF BDNF

Molecular functions related to Ocular Dominance according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor activity GO:0038023 9.73 NGFR GRIN2B GRIN2A GRIN1
2 amyloid-beta binding GO:0001540 9.67 NGFR GRIN2B GRIN2A GRIN1
3 growth factor activity GO:0008083 9.65 NTF3 NGF BDNF
4 ligand-gated ion channel activity GO:0015276 9.58 GRIN2B GRIN2A GRIN1
5 ionotropic glutamate receptor activity GO:0004970 9.5 GRIN2B GRIN2A GRIN1
6 glycine binding GO:0016594 9.46 GRIN2B GRIN1
7 glutamate binding GO:0016595 9.43 GRIN2B GRIN1 GAD1
8 NMDA glutamate receptor activity GO:0004972 9.33 GRIN2B GRIN2A GRIN1
9 glutamate-gated calcium ion channel activity GO:0022849 9.13 GRIN2B GRIN2A GRIN1
10 nerve growth factor receptor binding GO:0005163 8.8 NTF3 NGF BDNF

Sources for Ocular Dominance

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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