MCID: OCL004
MIFTS: 24

Ocular Hyperemia

Categories: Eye diseases, Neuronal diseases

Aliases & Classifications for Ocular Hyperemia

MalaCards integrated aliases for Ocular Hyperemia:

Name: Ocular Hyperemia 12 15 70
Hyperemia of Conjunctiva 12
Hyperemia Eye 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1248
SNOMED-CT 67 359610006
UMLS 70 C0155169

Summaries for Ocular Hyperemia

MalaCards based summary : Ocular Hyperemia, also known as hyperemia of conjunctiva, is related to corneal dystrophy, groenouw type i and macular dystrophy, corneal, and has symptoms including redness of eye An important gene associated with Ocular Hyperemia is PTGFR (Prostaglandin F Receptor), and among its related pathways/superpathways are Signaling by Rho GTPases and Oxytocin signaling pathway. Affiliated tissues include eye and endothelial.

Related Diseases for Ocular Hyperemia

Diseases related to Ocular Hyperemia via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 corneal dystrophy, groenouw type i 10.1 TGFBI CHST5
2 macular dystrophy, corneal 10.0 TGFBI CHST5
3 sorsby fundus dystrophy 10.0 CHST5 ARMS2
4 stromal dystrophy 10.0 TGFBI CHST5
5 corneal endothelial dystrophy 9.9 TGFBI SLC6A2 CHST5
6 intraocular pressure quantitative trait locus 9.9
7 47,xyy 9.9
8 transient refractive change 9.7 MYLK EDN1
9 coronary artery vasospasm 9.7 ROCK1 EDN1
10 optic nerve hypoplasia, bilateral 9.5 RPE65 EDN1

Graphical network of the top 20 diseases related to Ocular Hyperemia:



Diseases related to Ocular Hyperemia

Symptoms & Phenotypes for Ocular Hyperemia

UMLS symptoms related to Ocular Hyperemia:


redness of eye

Drugs & Therapeutics for Ocular Hyperemia

Search Clinical Trials , NIH Clinical Center for Ocular Hyperemia

Genetic Tests for Ocular Hyperemia

Anatomical Context for Ocular Hyperemia

MalaCards organs/tissues related to Ocular Hyperemia:

40
Eye, Endothelial

Publications for Ocular Hyperemia

Articles related to Ocular Hyperemia:

(show top 50) (show all 106)
# Title Authors PMID Year
1
Efficacy and safety of fixed-combination brimonidine tartrate/timolol maleate in primary open-angle glaucoma, including normal-tension glaucoma. 61
33591471 2021
2
Distinguishing Features of Anterior Uveitis Caused by Herpes Simplex Virus, Varicella-Zoster Virus and Cytomegalovirus. 61
33773985 2021
3
Granulomatous uveitis and choroidal detachment in a patient after topical treatment with Bimatoprost: A case report. 61
33508974 2021
4
DIAGNOSTIC VALUE OF THE REACTION AT THE BACILLUS CALMETTE-GUÉRIN VACCINATION SITE IN KAWASAKI DISEASE. 61
32876305 2021
5
Nodular anterior scleritis associated with Berger's disease. 61
33470345 2021
6
Brinzolamide/brimonidine fixed-dose combination bid as an adjunct to a prostaglandin analog for open-angle glaucoma/ocular hypertension. 61
31595773 2021
7
Safety and Comfort of an Innovative Drug Delivery Device in Healthy Subjects. 61
33384889 2020
8
Effect of Scleral Lens Oxygen Permeability on Corneal Physiology. 61
32932393 2020
9
Ocular Sporotrichosis. 61
32885097 2020
10
A Case of Metastatic Iris Tumor Observed With Anterior Segment Optical Coherence Tomography Before and After Radiation Therapy. 61
32606198 2020
11
Corneal Perforation during Combination Chemotherapy including Cetuximab in a Patient with a History of Herpetic Keratitis. 61
32724688 2020
12
Hemicrania Continua Subsequent to Vertebral Artery Dissection: A Case Report. 61
31611169 2019
13
Comparative efficacy of topical oclacitinib 0.1% and tacrolimus 0.01% in canine keratoconjunctivitis sicca. 61
30724448 2019
14
24-Hour Intraocular Pressure Control with Fixed-dose Combination Brinzolamide 1%/Brimonidine 0.2%: A Multicenter, Randomized Trial. 61
30403988 2019
15
A Highly Selective Rho-Kinase Inhibitor (ITRI-E-212) Potentially Treats Glaucoma Upon Topical Administration With Low Incidence of Ocular Hyperemia. 61
30735565 2019
16
Efficacy and Safety of Brinzolamide as Add-On to Prostaglandin Analogues or β-Blocker for Glaucoma and Ocular Hypertension: A Systematic Review and Meta-Analysis. 61
31293419 2019
17
Ocular Impression-Taking-Which Material Is Best? 61
29505434 2019
18
Efficacy And Safety Of Travoprost Versus Timolol To Treat Early-Onset Ocular Hypertension Secondary To Vitrectomy: A Randomized Trial. 61
31686785 2019
19
A Randomized, Controlled Phase I/II Study to Evaluate the Safety and Efficacy of MGV354 for Ocular Hypertension or Glaucoma. 61
29802818 2018
20
A Novel Selective Soluble Guanylate Cyclase Activator, MGV354, Lowers Intraocular Pressure in Preclinical Models, Following Topical Ocular Dosing. 61
29610853 2018
21
Tivanisiran, a novel siRNA for the treatment of dry eye disease. 61
29569947 2018
22
Topical Olopatadine in the Treatment of Allergic Conjunctivitis: A Systematic Review and Meta-analysis. 61
27192186 2017
23
A 3-month safety and efficacy study of travoprost 0.004% ophthalmic solution compared with timolol in pediatric patients with glaucoma or ocular hypertension. 61
28887006 2017
24
[Reactive Arthritis during the Second Course of Intravesical BCG Therapy Requiring Administration of Methotrexate : A Case Report]. 61
28889718 2017
25
Prospective Observational Post-Marketing Study of Tafluprost for Glaucoma and Ocular Hypertension: Effectiveness and Treatment Persistence. 61
28502035 2017
26
Adherence to Fixed-Combination Versus Unfixed Travoprost 0.004%/Timolol 0.5% for Glaucoma or Ocular Hypertension: A Randomized Trial. 61
27993589 2017
27
Ocular Hypotensive Effect of ONO-9054, an EP3/FP Receptor Agonist: Results of a Randomized, Placebo-controlled, Dose Escalation Study. 61
27300645 2016
28
A Randomized Phase 1 Dose Escalation Study to Evaluate Safety, Tolerability, and Pharmacokinetics of Trabodenoson in Healthy Adult Volunteers. 61
27046445 2016
29
Results at 2 Years after Gene Therapy for RPE65-Deficient Leber Congenital Amaurosis and Severe Early-Childhood-Onset Retinal Dystrophy. 61
27102010 2016
30
Association between glaucoma eye drops and hyperemia. 61
26847553 2016
31
Meta-analysis of the Efficacy and Safety of Latanoprost Monotherapy in Patients With Angle-closure Glaucoma. 61
25383466 2016
32
Efficacy and tolerability of brinzolamide/brimonidine suspension and prostaglandin analogs in patients previously treated with dorzolamide/timolol solution and prostaglandin analogs. 61
27099466 2016
33
Quantifying Ocular Surface Inflammation and Correlating It With Inflammatory Cell Infiltration In Vivo: A Novel Method. 61
26529042 2015
34
Effect of benzalkonium chloride-free travoprost on intraocular pressure and ocular surface symptoms in patients with glaucoma previously on latanoprost: an open-label study. 61
26563363 2015
35
Evaluation of the Effect of Latanoprostene Bunod Ophthalmic Solution, 0.024% in Lowering Intraocular Pressure over 24 h in Healthy Japanese Subjects. 61
26563323 2015
36
Ocular risk management in patients undergoing general anesthesia: an analysis of 39,431 surgeries. 61
26247665 2015
37
Double-masked, randomized, dose-response study of AR-13324 versus latanoprost in patients with elevated intraocular pressure. 61
25270273 2015
38
Two cases of adult-onset Still's disease with orbital inflammatory lesions originating from the lacrimal gland. 61
26466709 2015
39
Efficacy and safety of fixed-combination travoprost 0.004%/timolol 0.5% in patients transitioning from bimatoprost 0.03%/timolol 0.5% combination therapy. 61
26005326 2015
40
Clinical effectiveness of brinzolamide 1%-brimonidine 0.2% fixed combination for primary open-angle glaucoma and ocular hypertension. 61
26648686 2015
41
PRESERVATIVES FROM THE EYE DROPS AND THE OCULAR SURFACE. 61
27373107 2015
42
Superoxide Dismutase 1 Nanozyme for Treatment of Eye Inflammation. 61
26697135 2015
43
Late-day intraocular pressure-lowering efficacy and tolerability of travoprost 0.004% versus bimatoprost 0.01% in patients with open-angle glaucoma or ocular hypertension: a randomized trial. 61
25432143 2014
44
Efficacy, safety, and tolerability of preservative-free fixed combination of tafluprost 0.0015%/timolol 0.5% versus concomitant use of the ingredients. 61
24738883 2014
45
A phase II study of dacetuzumab (SGN-40) in patients with relapsed diffuse large B-cell lymphoma (DLBCL) and correlative analyses of patient-specific factors. 61
24919462 2014
46
Intraocular pressure-lowering efficacy of dorzolamide/timolol fixed combination in normal-tension glaucoma. 61
23377586 2014
47
An observational study of bimatoprost 0.01% in patients on prior intraocular pressure-lowering therapy: the Canadian Lumigan(®) RC Early Analysis Review (CLEAR) trial. 61
24920879 2014
48
An evaluation of therapeutic noninferiority of 0.005% latanoprost ophthalmic solution and xalatan in patients with glaucoma or ocular hypertension. 61
22595934 2013
49
Development of automated conjunctival hyperemia analysis software. 61
24104935 2013
50
[Effects of silicone punctal plugs for tear deficiency dry eye patients]. 61
23714033 2013

Variations for Ocular Hyperemia

Expression for Ocular Hyperemia

Search GEO for disease gene expression data for Ocular Hyperemia.

Pathways for Ocular Hyperemia

Pathways related to Ocular Hyperemia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.53 WIPF3 ROCK1 PPP1R14A MYLK
2
Show member pathways
11.38 ROCK1 PPP1R14A MYLK EDN1
3
Show member pathways
11.33 ROCK1 MYLK EDN1
4 10.98 ROCK1 MYLK
5 10.79 MYLK EDN1
6 10.63 PTGFR EDN1

GO Terms for Ocular Hyperemia

Biological processes related to Ocular Hyperemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 retina homeostasis GO:0001895 9.26 RPE65 ARMS2
2 positive regulation of cardiac muscle hypertrophy GO:0010613 9.16 ROCK1 EDN1
3 smooth muscle contraction GO:0006939 8.96 ROCK1 MYLK
4 response to transforming growth factor beta GO:0071559 8.62 ROCK1 EDN1

Sources for Ocular Hyperemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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